thiouracil has been researched along with kojic-acid* in 1 studies
1 other study(ies) available for thiouracil and kojic-acid
| Article | Year |
|---|---|
Human hair follicle pigmentary unit as a direct target for modulators of melanogenesis, as studied by [14C]-2-thiouracil incorporation.
The purpose of this study was to evaluate human hair follicle melanogenic activity using the [14C]-2-thiouracil, which was known to incorporate into nascent melanins. Results obtained on pigmented, grey and non-pigmented hair follicles demonstrated that [(14)C]-2-TU incorporation was restricted to the melanogenic compartment with a strong accumulation located around dermal papilla and within the fibre of pigmented hair follicles. Quantitative analysis of [(14)C]-2-TU incorporation showed a significant increase in pigmented hair follicles upon stimulation with 1 microm forskolin concomitant to an increase in tyrosinase levels. A strong significant decrease in [14C]-2-TU incorporation was noted, when hair follicles were incubated with the tyrosinase competitive inhibitor kojic acid (200 microm). Incubation with the MC1-R agonist alpha-MSH (0.2 microm) did not induce a significant stimulation of hair melanogenesis. The present model could thus represent a useful new tool to identify modulators of human hair pigmentation. Topics: alpha-MSH; Biopsy; Carbon Radioisotopes; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Hair Follicle; Humans; Melanins; Middle Aged; Monophenol Monooxygenase; Pyrones; Receptor, Melanocortin, Type 1; Skin Pigmentation; Thiouracil | 2009 |