thiouracil and 5-fluoroorotic-acid

thiouracil has been researched along with 5-fluoroorotic-acid* in 1 studies

Other Studies

1 other study(ies) available for thiouracil and 5-fluoroorotic-acid

Article	Year
Analogues of pyrimidine base precursors as antiphytoviral agents. Antiviral research, 1987, Volume: 7, Issue:3 Dihydroorotic acid hydrazide (DHOH) did not inhibit the replication of potatovirus X (PVX) in leaf disks of Nicotiana tabacum 'Samsun'. In contrast, 5-fluoroorotic acid (5-FOA) completely inhibited the replication of PVX, as demonstrated by a serological virus assay as well as a local lesion bioassay using Gomphrena globosa as the test plant. The corresponding base analogue 5-fluorouracil (5-FU) had only a weak inhibitory effect. Time-course inhibition experiments in synchronized virus-infected leaf disks led us to conclude that 5-FOA, as well as 5-azadihydrouracil (5-ADHU), an uracil catabolite analogue, inhibit the same early event in virus infection. Neither 5-FOA nor 5-ADHU had a direct inactivating effect on free PVX virions. Topics: Antiviral Agents; Cycloheximide; Fluorouracil; Orotic Acid; Plant Viruses; Thiouracil; Triazines; Virus Replication	1987

Article

Year

Analogues of pyrimidine base precursors as antiphytoviral agents.

Antiviral research, 1987, Volume: 7, Issue:3

Dihydroorotic acid hydrazide (DHOH) did not inhibit the replication of potatovirus X (PVX) in leaf disks of Nicotiana tabacum 'Samsun'. In contrast, 5-fluoroorotic acid (5-FOA) completely inhibited the replication of PVX, as demonstrated by a serological virus assay as well as a local lesion bioassay using Gomphrena globosa as the test plant. The corresponding base analogue 5-fluorouracil (5-FU) had only a weak inhibitory effect. Time-course inhibition experiments in synchronized virus-infected leaf disks led us to conclude that 5-FOA, as well as 5-azadihydrouracil (5-ADHU), an uracil catabolite analogue, inhibit the same early event in virus infection. Neither 5-FOA nor 5-ADHU had a direct inactivating effect on free PVX virions.

Topics: Antiviral Agents; Cycloheximide; Fluorouracil; Orotic Acid; Plant Viruses; Thiouracil; Triazines; Virus Replication

1987