thiorphan and substance p

thiorphan has been researched along with substance p in 69 studies

Research

Studies (69)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (28.99)	18.7374
1990's	39 (56.52)	18.2507
2000's	9 (13.04)	29.6817
2010's	1 (1.45)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Debuchi, H; Nakagawa, H	1
Hughes, TK; Paemen, LR; Stefano, GB	1
Drazen, JM; Martins, MA; Shore, SA	2
Bertrand, C; Da Silva, A; Dhuy, J; Landry, Y; Waeldelé, F	1
Barnes, PJ; Chung, KF; Lecomte, JM; Nichol, GM; O'Connor, BJ	1
Buckner, CK; DeHaas, CJ; Krell, RD; Kusner, EJ; Lengel, DJ; Marks, RL	1
Håkanson, R; Wang, ZY	1
Drazen, JM; Gerard, C; Gerard, NP; Martins, MA; Shore, SA	1
Back, SA; Gorenstein, C	1
Dolara, P; Maggi, CA; Morbidelli, L; Pacini, M; Ziche, M	1
Barnes, PJ; Chung, KF; Lötvall, JO; Skoogh, BE	1
Kondo, M; Takizawa, T; Tamaoki, J	1
Anderson, JA; Duzman, E; Hernandez, E; Malfroy, B	1
Anderson, JA; Binder, PS; Kullerstrand, L; Lucas, C; Malfroy, B; Richard, NR	1
Harris, KE; Patterson, R	1
Geppetti, P; Grassi, J; Maillet, S; Mantellini, P; Renzi, D; Santicioli, P; Surrenti, C; Theodorsson, E	1
Lim, JC; Webber, SE; Widdicombe, JG	1
Barnes, J; Frossard, N	1
Cockerham, SL; Silbaugh, SA; Stengel, PW	1
Kehl, LJ	1
Borson, DB; Caughey, G; Corrales, R; Gold, M; Nadel, JA; Ramachandran, J; Varsano, S; Viro, N	1
Stimler-Gerard, NP	1
Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A	1
Borson, DB; Nadel, JA; Sekizawa, K; Tamaoki, J	1
Basbaum, CB; Borson, DB; Graf, PD; Nadel, JA; Sekizawa, K; Tamaoki, J	1
Coats, SR; Drazen, JM; Shore, SA; Stimler-Gerard, NP	1
Advenier, C; Devillier, P; Drapeau, G; Marsac, J; Regoli, D	1
Borson, DB; Graf, PD; Kohrogi, H; Nadel, JA; Sekizawa, K	1
Borson, DB; Djokic, TD; Nadel, JA; Sekizawa, K	1
Borson, DB; Djokic, TD; Dusser, DJ; Graf, PD; Nadel, JA; Sekizawa, K	1
Drazen, JM; Gerard, NP; Shore, SA	1
Drapeau, G; Maggi, CA; Meli, A; Patacchini, R; Regoli, D; Renzi, D; Rovero, P; Santicioli, P; Surrenti, C	1
Geppetti, P; Maggi, CA; Rubini, I; Santicioli, P; Sicuteri, F; Spillantini, MG	1
Maggi, CA; Meli, A; Patacchini, R; Rovero, P	1
Cecconi, R; Geppetti, P; Giuliani, S; Maggi, CA; Meli, A; Patacchini, R; Santicioli, P	1
Barbanti, G; Beneforti, P; Maggi, CA; Meli, A; Patacchini, R; Rovero, P; Santicioli, P; Turini, D	1
Webber, SE	1
Cherniack, NS; Deal, EC; Haxhiu, MA; van Lunteren, E	1
Chou, J; Costa, E; Del Rio, J; Tang, J; Yang, HY	1
Bendele, AM; Cockerham, SL; Silbaugh, SA; Stengel, PW	2
Dusser, DJ; Lurie, A; Nadel, JA; Roisman, G; Siney, H	1
Christian, EP; Stow, RB; Talerico, SD; Turner, CR; Williams, JC	1
Joos, GF; Kips, JC; Pauwels, RA	1
Alkon, J; Coburn, RF; Dey, RD; Mitchell, H	1
Bertrand, C; Da Silva, A; Landry, Y	1
Kurihara, T; Otsuka, M; Yoshioka, K	1
Coupar, IM; Kerr, KP; Mitchelson, F	1
Graamans, K; Huizing, EH; Schuil, PJ; Ten Berge, M; Van Gelder, JM	1
Gomes, BC; Hubbs, SJ; Stow, RB; Turner, CR; Williams, JC	1
Baraniuk, JN; Gawin, AZ; Kaliner, MA	1
Hosoki, R; Otsuka, M; Saito, K; Seno, N; Suzuki, H; Yanagisawa, M	1
Chan, CC; Rodger, IW; Savoie, C; Tousignant, C	1
Costa, C; Cozzolino, A; Esposito, C; Falciani, M; Filippelli, A; Porta, R; Rossi, F	1
Gontijo, JR; Kopp, UC; Smith, LA	1
Beckers, JF; Delaunois, A; Dessy-Doizé, C; Gustin, P; Nemery, B; Nemmar, A; Sulon, J	1
Exintaris, B; Lang, RJ	1
Carter, JD; Devlin, RB; Oortgiesen, M; Simon, SA; Veronesi, B	1
Coupar, IM; Kerr, KP; Thai, B	1
Ansai, T; Awano, S; Carson, JA; Takehara, T; Turner, AJ; Yu, W	1
Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C	1
Brooks, DP; Edwards, RM; Pullen, MA; Sulpizio, AC	1
De Lima, TC; Duarte, FS; Testolin, R	1
Burssens, P; De Paepe, Y; Depaepe, Y; Forsyth, R; Steyaert, A; van Ovost, EJ; Verdonk, R	1
Burssens, PJ; Steyaert, AE; Vanderstraeten, GG; Verbeeck, RM; Vercruysse, CW	1
Dournaud, P; Fontaine, RH; Gressens, P; Lebas, F; Lelièvre, V; Leroux, P; Medja, F; Ouimet, T; Rougeot, C; Saria, A	1
Amantini, C; Lucciarini, R; Mosca, M; Perfumi, MC; Santoni, G	1
Berry, C; Biggerstaff, F; Clarke, A; Dalzell, JR; Hillier, C; McMurray, JJ; Padmanabhan, N; Petrie, MC; Seed, A; Whelan, CJ	1

Trials

2 trial(s) available for thiorphan and substance p

Article	Year
Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects. European journal of clinical pharmacology, 1992, Volume: 42, Issue:5 Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Neprilysin; Skin; Substance P; Sulfites; Thiorphan	1992
Role of neutral endopeptidase and kininase II on substance P-induced increase in nasal obstruction in patients with allergic rhinitis. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1 Topics: Administration, Intranasal; Administration, Oral; Adult; Airway Resistance; Analysis of Variance; Cilazapril; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Humans; Male; Nasal Obstruction; Nasal Provocation Tests; Neprilysin; Peptidyl-Dipeptidase A; Rhinitis, Allergic, Perennial; Substance P; Thiorphan	1994

Article

Year

Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects.

European journal of clinical pharmacology, 1992, Volume: 42, Issue:5

Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Neprilysin; Skin; Substance P; Sulfites; Thiorphan

1992

Role of neutral endopeptidase and kininase II on substance P-induced increase in nasal obstruction in patients with allergic rhinitis.

American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:1

Topics: Administration, Intranasal; Administration, Oral; Adult; Airway Resistance; Analysis of Variance; Cilazapril; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Humans; Male; Nasal Obstruction; Nasal Provocation Tests; Neprilysin; Peptidyl-Dipeptidase A; Rhinitis, Allergic, Perennial; Substance P; Thiorphan

1994

Other Studies

67 other study(ies) available for thiorphan and substance p

Article	Year
Inactivation of substance P by granulation tissue-derived gelatinase. Biochemical pharmacology, 1992, Nov-03, Volume: 44, Issue:9 Topics: Animals; Captopril; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Gelatin; Granulation Tissue; Hydrolysis; Kinetics; Male; Peptide Fragments; Protease Inhibitors; Rats; Rats, Wistar; Substance P; Thiorphan	1992
Autoimmunoregulation: differential modulation of CD10/neutral endopeptidase 24.11 by tumor necrosis factor and neuropeptides. Journal of neuroimmunology, 1992, Volume: 41, Issue:1 Topics: Animals; Autoimmunity; Bivalvia; Dose-Response Relationship, Immunologic; Enkephalin, Methionine; Gene Expression Regulation; Glycopeptides; Granulocytes; Hemocytes; Humans; In Vitro Techniques; Melanocyte-Stimulating Hormones; Neprilysin; Neuropeptides; Substance P; Thiorphan; Tumor Necrosis Factor-alpha	1992
Effect of the NEP inhibitor SCH32615 on airway responses to intravenous substance P in guinea pigs. Journal of applied physiology (Bethesda, Md. : 1985), 1992, Volume: 73, Issue:5 Topics: Airway Resistance; Animals; Blood Pressure; Captopril; Dipeptides; Guinea Pigs; Injections, Intravenous; Male; Neprilysin; Neurokinin A; Substance P; Thiorphan	1992
Endopeptidase 24.15 modulates bradykinin-induced contraction in guinea-pig trachea. European journal of pharmacology, 1992, Feb-25, Volume: 212, Issue:1 Topics: Amino Acid Sequence; Animals; Bradykinin; Dose-Response Relationship, Drug; Guinea Pigs; Male; Metalloendopeptidases; Molecular Sequence Data; Muscle Contraction; Oligopeptides; Peptidyl-Dipeptidase A; Substance P; Thiorphan; Trachea	1992
Tachykinin-induced dyspnea in conscious guinea pigs. European journal of pharmacology, 1992, Jan-21, Volume: 210, Issue:3 Topics: Aerosols; Animals; Drug Interactions; Dyspnea; Guinea Pigs; Male; Neurokinin A; SRS-A; Substance P; Thiorphan	1992
Effect of resiniferatoxin on the isolated rabbit iris sphincter muscle: comparison with capsaicin and bradykinin. European journal of pharmacology, 1992, Mar-24, Volume: 213, Issue:2 Topics: Animals; Bradykinin; Capsaicin; Captopril; Diterpenes; Electric Stimulation; Female; Iris; Male; Muscle Contraction; Rabbits; Substance P; Tachykinins; Tachyphylaxis; Thiorphan	1992
Peptidase modulation of the pulmonary effects of tachykinins in tracheal superfused guinea pig lungs. The Journal of clinical investigation, 1990, Volume: 85, Issue:1 Topics: Animals; Captopril; Dipeptides; Guinea Pigs; Kinetics; Lung; Male; Neurokinin A; Peptide Hydrolases; Perfusion; Substance P; Thiorphan; Trachea	1990
Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat brainstem. The Journal of comparative neurology, 1990, Jun-01, Volume: 296, Issue:1 Topics: Animals; Brain Stem; Enkephalins; Enzyme Inhibitors; Glycopeptides; Histocytochemistry; Male; Neprilysin; Rats; Rats, Inbred Strains; Substance P; Thiorphan	1990
NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins. British journal of pharmacology, 1990, Volume: 100, Issue:1 Topics: Autoradiography; Cell Division; Fibroblasts; Humans; In Vitro Techniques; Neurokinin A; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Skin; Substance P; Tachykinins; Thiorphan; Thymidine	1990
Effects of aerosolised substance P on lung resistance in guinea-pigs: a comparison between inhibition of neutral endopeptidase and angiotensin-converting enzyme. British journal of pharmacology, 1990, Volume: 100, Issue:1 Topics: Acetylcholine; Aerosols; Airway Resistance; Analgesics; Animals; Endopeptidases; Guinea Pigs; Lung; Male; Peptidyl-Dipeptidase A; Propranolol; Substance P; Thiorphan	1990
Neutral endopeptidase inhibitor potentiates the tachykinin-induced increase in ciliary beat frequency in rabbit trachea. The American review of respiratory disease, 1990, Volume: 142, Issue:2 Topics: Animals; Male; Mucociliary Clearance; Neprilysin; Neurokinin A; Rabbits; Stimulation, Chemical; Substance P; Thiorphan; Trachea	1990
Recombinant enkephalinase effectively inhibits substance P-induced miosis in the rabbit eye cup model. Current eye research, 1990, Volume: 9, Issue:6 Topics: Animals; Atropine; Disease Models, Animal; Female; Humans; Iris; Miosis; Neprilysin; Rabbits; Recombinant Proteins; Substance P; Thiorphan	1990
Substance P contracts the human iris sphincter: possible modulation by endogenous enkephalinase. Regulatory peptides, 1990, Volume: 29, Issue:1 Topics: Aged; Aged, 80 and over; Carbachol; Female; Humans; Immunoenzyme Techniques; In Vitro Techniques; Iris; Male; Models, Biological; Muscle Contraction; Neprilysin; Substance P; Thiorphan	1990
Rhesus monkey airway responses to substance P. International archives of allergy and applied immunology, 1990, Volume: 91, Issue:4 Topics: Administration, Inhalation; Airway Obstruction; Animals; Antigens, Helminth; Ascaris; Asthma; Female; Lung; Macaca mulatta; Male; Respiratory Function Tests; Skin; Substance P; Thiorphan	1990
Enzyme immunoassay for tachykinin-like immunoreactivity in the guinea pig spinal cord. Journal of neurochemistry, 1991, Volume: 56, Issue:1 Topics: Acetylcholinesterase; Animals; Capsaicin; Eledoisin; Guinea Pigs; Immunoenzyme Techniques; Kassinin; Male; Neurokinin A; Neurokinin B; Physalaemin; Potassium; Radioimmunoassay; Spinal Cord; Substance P; Tachykinins; Thiorphan	1991
The effects of calcitonin gene-related peptide on submucosal gland secretion and epithelial albumin transport in the ferret trachea in vitro. British journal of pharmacology, 1991, Volume: 102, Issue:1 Topics: Albumins; Animals; Calcitonin Gene-Related Peptide; Evoked Potentials; Exocrine Glands; Female; Ferrets; In Vitro Techniques; Male; Methacholine Compounds; Mucus; Muramidase; Substance P; Thiorphan; Trachea	1991
Effect of tachykinins in small human airways. Neuropeptides, 1991, Volume: 19, Issue:3 Topics: Bronchi; Bronchoconstriction; Carbachol; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Substance P; Thiorphan	1991
Peptidase modulation of the pulmonary effects of tachykinins. International archives of allergy and applied immunology, 1991, Volume: 94, Issue:1-4 Topics: Animals; Captopril; Dipeptides; Guinea Pigs; In Vitro Techniques; Lung; Neprilysin; Neurokinin A; Perfusion; Substance P; Thiorphan	1991
Effects of inhaled or intravenous thiorphan on substance P-induced airway obstruction. Agents and actions. Supplements, 1991, Volume: 34 Topics: Aerosols; Airway Obstruction; Animals; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Injections, Intravenous; Lung; Male; Substance P; Thiorphan	1991
Analgesia after inhibition of enkephalin degradation. Journal of the American Dental Association (1939), 1986, Volume: 112, Issue:2 Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Neprilysin; Protease Inhibitors; Spinal Cord; Substance P; Thiorphan; Tiopronin	1986
Enkephalinase inhibitors potentiate substance P-induced secretion of 35SO4-macromolecules from ferret trachea. Experimental lung research, 1987, Volume: 12, Issue:1 Topics: Animals; Drug Synergism; Endopeptidases; Enkephalin, Methionine; Ferrets; Glycopeptides; In Vitro Techniques; Male; Molecular Weight; Mucus; Neprilysin; Protease Inhibitors; Rabbits; Substance P; Sulfates; Thiorphan; Tiopronin; Trachea	1987
Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung. The Journal of clinical investigation, 1987, Volume: 79, Issue:6 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Complement C3; Complement C3a; Complement C5; Complement C5a; Drug Interactions; Endopeptidases; Glycopeptides; Guinea Pigs; Lung; Muscle Contraction; N-Formylmethionine Leucyl-Phenylalanine; Peptidyl-Dipeptidase A; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Thiorphan; Tiopronin; Trachea	1987
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2 Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin	1987
Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea. Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 63, Issue:4 Topics: Airway Resistance; Amino Acids, Sulfur; Animals; Electric Stimulation; Ferrets; In Vitro Techniques; Metalloendopeptidases; Neprilysin; Substance P; Thiorphan; Tiopronin; Trachea	1987
Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Epithelium; Ferrets; In Vitro Techniques; Metalloendopeptidases; Muscle Contraction; Neprilysin; Neurokinin A; Neurokinin B; Neuropeptides; Substance P; Tachykinins; Thiorphan; Tiopronin; Trachea	1987
Substance P-induced bronchoconstriction in the guinea pig. Enhancement by inhibitors of neutral metalloendopeptidase and angiotensin-converting enzyme. The American review of respiratory disease, 1988, Volume: 137, Issue:2 Topics: Amino Acids, Sulfur; Angiotensin-Converting Enzyme Inhibitors; Animals; Bronchi; Captopril; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Methacholine Chloride; Methacholine Compounds; Plethysmography, Whole Body; Protease Inhibitors; Respiration, Artificial; Substance P; Thiorphan; Time Factors; Tiopronin	1988
Comparison of the effects of epithelium removal and of an enkephalinase inhibitor on the neurokinin-induced contractions of guinea-pig isolated trachea. British journal of pharmacology, 1988, Volume: 94, Issue:3 Topics: Airway Resistance; Animals; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Neprilysin; Neurokinin A; Neurokinin B; Substance P; Tachykinins; Thiorphan; Trachea	1988
Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs. The Journal of clinical investigation, 1988, Volume: 82, Issue:6 Topics: Animals; Capsaicin; Cough; Drug Synergism; Glycopeptides; Guinea Pigs; Male; Neprilysin; Substance P; Thiorphan	1988
Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle. The American journal of physiology, 1989, Volume: 256, Issue:1 Pt 1 Topics: Animals; Drug Synergism; Duodenum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ferrets; Glycopeptides; Ileum; Intestines; Male; Muscle Contraction; Protease Inhibitors; Rats; Substance P; Thiorphan	1989
Inhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced noncholinergic contraction in guinea pig bronchi. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:1 Topics: Animals; Bronchi; Capsaicin; Electric Stimulation; Glycopeptides; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Neprilysin; Substance P; Thiorphan	1989
Substance P-induced effects in guinea pig lungs: effects of thiorphan and captopril. Journal of applied physiology (Bethesda, Md. : 1985), 1989, Volume: 66, Issue:3 Topics: Animals; Blood Pressure; Captopril; Chromatography, High Pressure Liquid; Guinea Pigs; In Vitro Techniques; Lung; Male; Perfusion; Pulmonary Artery; Substance P; Thiorphan	1989
Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins. European journal of pharmacology, 1989, Jun-08, Volume: 165, Issue:1 Topics: Animals; Captopril; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Peptide Fragments; Pyrrolidonecarboxylic Acid; Radioimmunoassay; Substance P; Tachykinins; Thiorphan	1989
Thiorphan increases capsaicin-evoked release of substance P from slices of dorsal spinal cord of guinea pig. Neuroscience letters, 1989, Aug-14, Volume: 103, Issue:1 Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Captopril; Female; Guinea Pigs; Kinetics; Male; Neprilysin; Neuropeptides; Spinal Cord; Substance P; Thiorphan	1989
The hamster isolated trachea: a new preparation for studying NK-2 receptors. European journal of pharmacology, 1989, Aug-03, Volume: 166, Issue:3 Topics: Animals; Atropine; Cricetinae; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Pyrilamine; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Tachykinins; Thiorphan; Trachea	1989
Multiple mechanisms in the motor responses of the guinea-pig isolated urinary bladder to bradykinin. British journal of pharmacology, 1989, Volume: 98, Issue:2 Topics: Animals; Apamin; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; Indomethacin; Kallidin; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Substance P; Tetrodotoxin; Thiorphan; Urinary Bladder	1989
Further studies on the motor response of the human isolated urinary bladder to tachykinins, capsaicin and electrical field stimulation. General pharmacology, 1989, Volume: 20, Issue:5 Topics: Adult; Aged; Autonomic Nervous System; Calcitonin Gene-Related Peptide; Capsaicin; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidonecarboxylic Acid; Substance P; Tachykinins; Thiorphan; Urinary Bladder	1989
Receptors mediating the effects of substance P and neurokinin A on mucus secretion and smooth muscle tone of the ferret trachea: potentiation by an enkephalinase inhibitor. British journal of pharmacology, 1989, Volume: 98, Issue:4 Topics: Animals; Female; Ferrets; In Vitro Techniques; Male; Mucus; Muramidase; Muscle Tonus; Muscle, Smooth; Neprilysin; Neurokinin A; Receptors, Cell Surface; Serum Albumin, Bovine; Substance P; Thiorphan; Trachea	1989
Central modulatory effects of tachykinin peptides on airway tone. Journal of the autonomic nervous system, 1989, Volume: 28, Issue:2 Topics: Airway Resistance; Animals; Cats; Female; Glycopeptides; Male; Medulla Oblongata; Neprilysin; Neurokinin A; Phrenic Nerve; Substance P; Thiorphan; Trachea	1989
Action of peptidase inhibitors on methionine5-enkephalin-arginine6-phenylalanine7 (YGGFMRF) and methionine5-enkephalin (YGGFM) metabolism and on electroacupuncture antinociception. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:2 Topics: Acupuncture Therapy; Analgesia; Animals; Captopril; Electronarcosis; Enkephalin, Methionine; Leucine; Male; Perfusion; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Thiorphan; Tiopronin	1984
Sulfuric acid induces airway hyperresponsiveness to substance P in the guinea pig. Agents and actions, 1993, Volume: 39 Spec No Topics: Administration, Inhalation; Animals; Bronchial Hyperreactivity; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Male; Substance P; Sulfuric Acids; Thiorphan	1993
Protective role for neuropeptides in acute pulmonary response to acrolein in guinea pigs. Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 75, Issue:6 Topics: Acrolein; Animals; Bronchoalveolar Lavage Fluid; Capsaicin; Erythrocyte Count; Guinea Pigs; Leukocyte Count; Lung; Male; Nerve Fibers; Neuropeptides; Nodose Ganglion; Respiratory Mechanics; Substance P; Tachykinins; Thiorphan	1993
In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:5 Topics: Airway Resistance; Animals; Atropine; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Captopril; Dose-Response Relationship, Drug; Indoles; Isoindoles; Male; Methysergide; Neurokinin A; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Tachykinin; Serotonin; Substance P; Thiorphan	1994
Capsaicin-sensitive stretch responses in ferret trachealis muscle. The Journal of physiology, 1994, Mar-01, Volume: 475, Issue:2 Topics: Animals; Capsaicin; Female; Ferrets; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Stress, Mechanical; Substance P; Thiorphan; Trachea	1994
Epithelium modulates the kinetics of the response to substance P and its intrinsic activity in the guinea-pig trachea. Fundamental & clinical pharmacology, 1994, Volume: 8, Issue:3 Topics: Animals; Carbachol; Epithelium; Guinea Pigs; Histamine; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Neurokinin A; Neurokinin B; Substance P; Thiorphan; Trachea	1994
Tachykininergic slow depolarization of motoneurones evoked by descending fibres in the neonatal rat spinal cord. The Journal of physiology, 1995, Jun-15, Volume: 485 ( Pt 3) Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ketanserin; Motor Neurons; Neurokinin A; Rats; Rats, Wistar; Spinal Nerve Roots; Substance P; Synaptic Transmission; Tachykinins; Thiorphan; Thyrotropin-Releasing Hormone	1995
Vagal nerve stimulation of the guinea-pig oesophagus. Acta physiologica Scandinavica, 1995, Volume: 154, Issue:2 Topics: Animals; Atropine; Calcium Channel Blockers; Capsaicin; Electric Stimulation; Esophagus; Ganglionic Blockers; Guinea Pigs; Hexamethonium; In Vitro Techniques; Male; omega-Conotoxin GVIA; Peptides; Physostigmine; Substance P; Thiorphan; Tubocurarine; Vagus Nerve	1995
Substance P and ciliary beat of human upper respiratory cilia in vitro. The Annals of otology, rhinology, and laryngology, 1995, Volume: 104, Issue:10 Pt 1 Topics: Adenoids; Culture Techniques; Humans; Mucociliary Clearance; Nasal Cavity; Nasal Mucosa; Substance P; Thiorphan	1995
Inhaled A23187 produces a preferential sensitization to substance P. The American review of respiratory disease, 1993, Volume: 147, Issue:1 Topics: Animals; Bronchial Provocation Tests; Bronchoconstriction; Calcimycin; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Lung Volume Measurements; Male; Neprilysin; Platelet Activating Factor; SRS-A; Substance P; Thiorphan	1993
Acrolein increases airway sensitivity to substance P and decreases NEP activity in guinea pigs. Journal of applied physiology (Bethesda, Md. : 1985), 1993, Volume: 74, Issue:4 Topics: Acrolein; Aerosols; Animals; Bronchoalveolar Lavage Fluid; Drug Resistance; Guinea Pigs; Injections, Intravenous; Male; Neprilysin; Proteins; Pulmonary Edema; Respiratory System; Substance P; Thiorphan	1993
Effects of substance P and calcitonin gene related peptide (CGRP) on guinea pig nasal mucosal secretion in vivo. Acta oto-laryngologica, 1993, Volume: 113, Issue:4 Topics: Administration, Intranasal; Albumins; Animals; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Exudates and Transudates; Guinea Pigs; Iodine Radioisotopes; Male; Nasal Mucosa; Proteins; Serum Albumin, Bovine; Substance P; Thiorphan; Time Factors	1993
Potentiating effect of peptidase inhibitors on a C fiber-evoked response in the isolated spinal cord preparation of the neonatal rat. Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2 Topics: Animals; Animals, Newborn; Captopril; Drug Synergism; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guanidines; Hydroxamic Acids; In Vitro Techniques; Kinetics; Leucine; Nerve Fibers; Neurokinin A; Protease Inhibitors; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Substance P; Tetrodotoxin; Thiorphan	1993
Involvement of NK1 and NK2 receptors in pulmonary responses elicited by non-adrenergic, non-cholinergic vagal stimulation in guinea-pigs. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:11 Topics: Animals; Benzamides; Bronchi; Bronchoconstriction; Capillary Permeability; Enalapril; Guinea Pigs; Male; Piperidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Thiorphan; Trachea; Vagus Nerve	1995
Transglutaminase-synthesized spermine derivative of substance P recognizes rat portal vein neurokinin-3 receptors. Life sciences, 1997, Volume: 60, Issue:6 Topics: Androstanes; Animals; Benzimidazoles; In Vitro Techniques; Male; Neurokinin A; Peptide Fragments; Physalaemin; Piperidines; Portal Vein; Rats; Rats, Wistar; Receptors, Neurokinin-3; Substance P; Thiorphan; Transglutaminases; Vasoconstriction	1997
CGRP activates renal pelvic substance P receptors by retarding substance P metabolism. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:1 Pt 2 Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Indoles; Isoindoles; Kidney; Kidney Pelvis; Male; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Thiorphan	1999
Inflammatory effect of intratracheal instillation of ultrafine particles in the rabbit: role of C-fiber and mast cells. Toxicology and applied pharmacology, 1999, Nov-01, Volume: 160, Issue:3 Topics: Animals; Capsaicin; Carbachol; Chemotaxis, Leukocyte; Female; Histamine; Histamine Antagonists; Intubation, Intratracheal; Lung; Male; Mast Cells; Microspheres; Nerve Fibers; Neutrophils; p-Methoxy-N-methylphenethylamine; Pneumonia; Polystyrenes; Rabbits; Receptors, Tachykinin; Substance P; Thiorphan	1999
Effects of nerve stimulation on spontaneously active preparations of the guinea pig ureter. Urological research, 1999, Volume: 27, Issue:5 Topics: Action Potentials; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Electrophysiology; Guinea Pigs; Humans; In Vitro Techniques; Motor Activity; Nervous System Physiological Phenomena; Neurokinin A; Peptides, Cyclic; Substance P; Tachykinins; Thiorphan; Ureter; Urinary Tract Physiological Phenomena	1999
Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. Neuropeptides, 1999, Volume: 33, Issue:6 Topics: Bronchi; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cell Line, Transformed; Cytokines; Epithelial Cells; Gene Expression; Humans; Interleukin-6; Interleukin-8; Peptide Fragments; Piperidines; Protease Inhibitors; RNA, Messenger; Substance P; Thiorphan; Tumor Necrosis Factor-alpha	1999
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors. British journal of pharmacology, 2000, Volume: 131, Issue:7 Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan	2000
Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1. Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48 Topics: Angiotensin I; Angiotensin II; Aspartic Acid Endopeptidases; Bacterial Proteins; Bradykinin; Chromatography, High Pressure Liquid; Endothelin-Converting Enzymes; Enzyme Activation; Enzyme Inhibitors; Glycopeptides; Humans; Hydrolysis; Inhibitory Concentration 50; Metalloendopeptidases; Neurotensin; Porphyromonas gingivalis; Substance P; Thiorphan	2002
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity. Proceedings of the National Academy of Sciences of the United States of America, 2003, Jul-08, Volume: 100, Issue:14 Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries	2003
The effect of acute angiotensin-converting enzyme and neutral endopeptidase 24.11 inhibition on plasma extravasation in the rat. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Dose-Response Relationship, Drug; Lung; Male; Neprilysin; Peptidyl-Dipeptidase A; Plasma; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Thiorphan	2004
Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats. Behavioural brain research, 2004, Oct-05, Volume: 154, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Indoles; Injections, Intraventricular; Male; Maze Learning; Microinjections; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P; Thiorphan; Time Factors	2004
Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing. Foot & ankle international, 2005, Volume: 26, Issue:10 Topics: Achilles Tendon; Animals; Captopril; Cell Proliferation; Collagen; Disease Models, Animal; Drug Combinations; Fibroblasts; Male; Neovascularization, Physiologic; Neprilysin; Protease Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Rupture; Substance P; Tendon Injuries; Thiorphan; Treatment Outcome; Wound Healing	2005
The effects of substance P on the biomechanic properties of ruptured rat Achilles' tendon. Archives of physical medicine and rehabilitation, 2006, Volume: 87, Issue:2 Topics: Achilles Tendon; Animals; Biomechanical Phenomena; Captopril; Male; Neurotransmitter Agents; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Rupture; Stress, Mechanical; Substance P; Thiorphan; Wound Healing	2006
Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. Brain : a journal of neurology, 2006, Volume: 129, Issue:Pt 12 Topics: Animals; Animals, Newborn; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebral Palsy; Excitatory Amino Acid Agonists; Female; Ibotenic Acid; Immunohistochemistry; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Neprilysin; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Protease Inhibitors; Receptors, Neurokinin-2; Seizures; Substance P; Thiorphan	2006
Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:1 Topics: Animals; Apoptosis; Caspase Inhibitors; Cell Survival; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; Male; Microtubule-Associated Proteins; Neprilysin; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Survivin; T-Lymphocytes; Thiorphan	2008
Effects of neutral endopeptidase (neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: studies with thiorphan and omapatrilat. Cardiovascular therapeutics, 2014, Volume: 32, Issue:1 Topics: Adrenomedullin; Aged; Angiotensin I; Arteries; Captopril; Female; Humans; Male; Middle Aged; Neprilysin; Protease Inhibitors; Pyridines; Substance P; Thiazepines; Thiorphan; Vasodilation	2014