thiorphan has been researched along with racecadotril in 150 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (12.67) | 18.7374 |
| 1990's | 56 (37.33) | 18.2507 |
| 2000's | 38 (25.33) | 29.6817 |
| 2010's | 32 (21.33) | 24.3611 |
| 2020's | 5 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Brimacombe, KR; Dulcey, AE; Goldsborough, AS; Gottesman, MM; Griffiths, G; Hall, MD; Handley, MD; Kannan, P; Pluchino, KM | 1 |
| Bruetschy, L; Coric, P; Fournié-Zaluski, MC; Lucas, E; Noble, F; Roques, BP; Turcaud, S | 1 |
| Baumer, P; Bergmann, JF; Chaussade, S; Couturier, D; Lecomte, JM; Schwartz, JC | 1 |
| Barnes, PJ; Chung, KF; Lecomte, JM; Nichol, GM; O'Connor, BJ | 1 |
| Bokszanska, A; Brinkman, EC; Cappendijk, SL; Dzoljic, M; Dzoljic, MR; Kaplan, CD; Korenhof, AM; Rupreht, J; Zijlstra, FJ | 1 |
| Baumer, P; Bertrand, J; Danquechin Dorval, E; Lecomte, JM; Schwartz, JC; Vetel, JM | 1 |
| Duboc, D; Fouchard, J; Guérin, F; Muffat-Joly, M; Schwartz, JC; Varin, J; Weber, S | 1 |
| Bousselmame, R; Costentin, J; Michael-Titus, A | 1 |
| Barnes, PJ; Chung, KF; Lötvall, JO; Skoogh, BE | 1 |
| Bousselmame, R; Costentin, J; Eustache, M; Michael-Titus, A | 1 |
| Ardaillou, R; Bodin, F; Dussaule, JC; Grangé, JD; Gros, C; Lecomte, JM; Schwartz, JC; Wolf, JP | 1 |
| Hirata, Y | 1 |
| Bralet, J; Danvy, D; Duhamel, L; Duhamel, P; Gros, C; Lecomte, JM; Noël, N; Plaquevent, JC; Schwartz, JC; Souque, A | 1 |
| Castaigne, A; Duboc, D; Dubois-Rande, JL; Gros, C; Kahn, JC; Lecomte, JM; Lim-Alexandre, C; Merlet, P; Patey, M; Schwartz, JC | 1 |
| Clerc, G; Duchier, J; Gros, C; Lecomte, JM; Lefrançois, P; Lim, C; Schwartz, JC | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Bourdel, MC; Hartmann, F; Lecomte, JM; Loo, H; Poirier, MF; Schwartz, JC | 1 |
| Han, J; Luo, F; Zhou, Y | 1 |
| Gros, C; Schwartz, JC; Souque, A | 2 |
| Bralet, J; Charpentier, S; Gros, C; Lecomte, JM; Mossiat, C; Schwartz, JC | 1 |
| Ardaillou, R; Baumer, P; Chaignon, B; Cournot, A; Duchier, J; Dussaule, JC; Gros, C; Lecomte, JM; Lim, C; Souque, A | 1 |
| Livingston, SJ; Sewell, RD; Smith, HJ; Williams, PS | 1 |
| Baumer, P; Cournot, A; Duchier, J; Gros, C; Lecomte, JM; Schwartz, JC; Souque, A | 1 |
| Bouvier, M; Grimaud, JC; Naudy, B; Salducci, J | 1 |
| Akoué, K; Alexandre, CL; Baumer, P; Bergmann, JF; Chaussade, S; Lecomte, JM; Nepveux, P; Schwartz, JC | 1 |
| Aceto, MD; Balster, RL; Beardsley, PM; Harris, LS; Knisely, JS | 1 |
| Hamilton, RF; Lake, JR; Malin, DH; Skolnick, MH | 1 |
| Caline, H; Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Jivegård, L; Moreau, J; Pollard, H; Schwartz, JC; Svanvik, J; Thune, A | 1 |
| Fanciullacci, M; Geppetti, P; Lecomte, JM; Michelacci, S; Sicuteri, F; Spillantini, MG | 1 |
| Costentin, J; Giros, B; Michael-Titus, A; Preterre, P | 1 |
| Livingston, SJ; Rooney, KF; Sewell, RD; Smith, HJ | 1 |
| Buéno, L; Liberge, M; Rivière, PM | 1 |
| Brion, F; Dam Trung Tuong, M; De la Baume, S; Schwartz, JC | 1 |
| Chaussade, S; Couturier, D; Guerre, J; Hamm, R; Lecomte, JM | 1 |
| Chariot, J; Chicau-Chovet, M; Dubrasquet, M; Lecomte, JM; Rozé, C; Tsocas, A | 1 |
| Buéno, L; Rivière, PJ | 1 |
| Artaud, F; Bouboutou, R; Bourgoin, S; Cesselin, F; Clot, AM; Fournie-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Costentin, J; Danvy, D; Duhamel, L; Duhamel, P; Giros, B; Gros, C; Lecomte, JM; Plaquevent, JC; Schwartz, JC; Vlaiculescu, A | 1 |
| Costentin, J; Lecomte, JM; Marçais-Collado, H; Schwartz, JC; Uchida, G | 1 |
| Chaillet, P; Costentin, J; Leboyer, M; Lecomte, JM; Llorens-Cortes, C; Marcais-Collado, H; Schwartz, JC; Vlaiculescu, A | 1 |
| Adjroud, O | 1 |
| Dusser, DJ; Lurie, A; Nadel, JA; Roisman, G; Siney, H | 1 |
| Grünfeld, JP; Hannedouche, T; Ikeni, A; Laborde, K; Lacour, B; Martinez, F; Natov, S; Savoiu, C; Schmitt, F | 1 |
| Hirth-Dietrich, C; Knorr, A; Stasch, JP; Wegner, M | 1 |
| Brouard, R; Brunner, HR; Burnier, M; Favrat, B; Lecomte, JM; Nussberger, J; Waeber, B | 1 |
| Abigerges, D; Armand, JP; de Costa, L; Gonçalves, E | 1 |
| Bérard, H; Dorval, ED; Gamelin, E; Picon, L; Regimbeau, C | 1 |
| Costentin, J; Khallouk-Bousselmame, R | 1 |
| Wilkins, MR | 1 |
| Dumont, P; Lambert, DM; Mergen, F; Poupaert, JH | 1 |
| Ardaillou, R; Dussaule, JC; Gros, C; Lecomte, JM; Michel, C; Mignon, F; Peraldi, MN | 1 |
| Benouali, S; Berard, H; Roche, M | 1 |
| Baumer, P; Berard, H; Lecomte, JM; Roge, J; Schwartz, JC | 1 |
| Berry, CJ; Fink, CA; Ghai, RD; Qiao, Y; Sakane, Y; Trapani, AJ | 1 |
| Hirth-Dietrich, C; Stasch, JP; Wegner, M | 1 |
| Baumer, P; Beaugerie, L; Berard, H; Chaussade, S; Le Quintrec, Y; Lecomte, JM; Pialoux, G; Rozenbaum, W; Schwartz, JC | 1 |
| Ganten, D; Hirth-Dietrich, C; Stasch, JP; Wegner, M | 1 |
| Bourdel, E; Costentin, J; Dubuc, I; Fehrentz, JA; Martinez, J; Van Kemmel, FM | 1 |
| Berard, H; Dimsity, G; Hinterleitner, TA; Krejs, GJ; Lecomte, JM; Petritsch, W | 1 |
| Kimura, M; Nakashima, M; Ohashi, K; Umemura, K | 1 |
| Cleland, JG; Swedberg, K | 1 |
| Gray, AM; Sewell, RD; Spencer, PS | 1 |
| Bastian, G; Bonnay, M; Cote, C; Cvitkovic, E; Hagipantelli, R; Herait, P; Mahjoubi, M; Mignard, D; Misset, JL; Saliba, F; Vassal, G | 1 |
| Bourin, M; Colombel, MC; Malinge, M; Vasar, E | 1 |
| Anastasopoulos, F; Briscoe, TA; Campbell, DJ; Duncan, AM; James, GM; Kladis, A | 1 |
| Hayashi, I; Ito, H; Izumi, T; Katori, M; Majima, M; Nakajima, S | 1 |
| Burnett, JC; Cody, RJ; Elkayam, U; Gattis, WA; Gheorghiade, M; Gilbert, J; Goldstein, S; Granger, CB; Kasper, EK; Katz, SD; Massie, BM; McKenney, JM; Messineo, FC; O'Connor, CM | 1 |
| Farthing, MJ | 1 |
| Baumer, P; Berard, H; Bueno, L; Lecomte, JM; Primi, MP | 1 |
| Baumer, P; Berard, H; Duval-Iflah, Y; Guillaume, P; Joulin, Y; Lecomte, JM; Raibaud, P | 1 |
| Baumer, P; Ben Khalifa, H; Berard, H; Hamza, H; Lecomte, JM | 1 |
| Berard, H; Fretault, N; Lecomte, JM; Vetel, JM | 1 |
| Berard, H; Fretault, N; Lecomte, JM; Turck, D | 1 |
| Beals, S; Hanson, B; Kutas, SM; Olivier, NB; Windram, S | 1 |
| Schwartz, JC | 1 |
| Lecomte, JM | 1 |
| Goetze, L; Maertins, T; von Keutz, E | 1 |
| Matheson, AJ; Noble, S | 1 |
| Goetze, L; Sisson, D; Solter, P; Thomas, W | 1 |
| Fujimura, A; Furukawa, K; Inaba, S; Mabuchi, H; Miyamori, I; Takeda, Y | 1 |
| Chea-Woo, E; Gutierrez, M; Salazar-Lindo, E; Santisteban-Ponce, J | 1 |
| Awad, L; Bleiberg, H; Bugat, R; Culine, S; Droz, JP; Freyer, G; Herait, P; Marty, M; Mignard, D; Rougier, P; Trillet-Lenoir, V | 1 |
| Audrain, S; Bellaiche, M; Cézard, JP; Duhamel, JF; Ginies, JL; Girardet, JP; Lamireau, T; Lecomte, JM; Maurage, C; Meyer, M; Morali, A; Olives, JP; Pharaon, I; Poujol, A; Sarles, J; Vaillant, JM; Whately-Smith, C | 1 |
| Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB | 1 |
| Prado, D | 1 |
| Brandenberger, G; Charloux, A; Doutreleau, S; Geny, B; Hannedouche, T; Piquard, F; Richard, R | 1 |
| Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C | 1 |
| Danvy, D; Leroux, R; Monteil, T; Plaquevent, JC; Sihel, M | 1 |
| Goldstein, S; Mishima, T; Sabbah, HN; Sharov, VG; Suzuki, G; Tanhehco, EJ; Tanimura, M; Todor, A | 1 |
| Awouters, F; Huighebaert, S; Tytgat, GN | 1 |
| Rao, SG | 1 |
| Alam, NH; Ashraf, H; Fuchs, GJ; Karim, MM; Khan, WA | 1 |
| Brooks, DP; Edwards, RM; Pullen, MA; Sulpizio, AC | 1 |
| Bhan, MK; Bhatnagar, S | 1 |
| Gogia, S; Nagpal, J | 1 |
| Liao, KF; Shieh, MJ; Wang, HH | 1 |
| Cezard, JP; Salazar-Lindo, E | 1 |
| Altomonte, G; Buonomo, A; Nucera, E; Patriarca, G; Sabato, V; Schiavino, D | 1 |
| Alam, S; Bhatnagar, S | 1 |
| Gao, S; Guo, Q; Huang, J; Liu, F; Xu, Y | 1 |
| Babu, JM; Reddy, GS; Reddy, KM; Sharma, MS; Sudhakar, P; Vyas, K | 1 |
| Turck, D | 1 |
| Chmielewska, A; Ruszczyński, M; Szajewska, H; Wieczorek, J | 1 |
| Xu, F; Xu, G; Yang, L | 1 |
| Goulet, O; Polanco, I; Salazar-Lindo, E; Tormo, R | 1 |
| Guo, H; Pan, Y; Qi, F; Sheng, L; Yin, H; Zhang, T | 1 |
| Baliga, RS; Hobbs, AJ; Lopez-Torondel, B; MacAllister, RJ; Madhani, M; Selwood, D; Visintin, C; Wilkins, MR; Zhao, L | 1 |
| Alústiza Martínez, E; Aseguinolaza Iparraguirre, I; Callén Blecua, MT; Emparanza Knörr, JI; Martínez Andueza, MC; Ozcoidi Erro, I | 1 |
| Armellino, C; Buccigrossi, V; Guarino, A | 1 |
| Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P | 1 |
| Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA | 1 |
| Abdel Razeq, SA; Elsherif, ZA; Fouad, MM; Hasan, MM; Mohamed, AO | 1 |
| Chang, CH; Chang, CK; Cheng, JT; Cheng, KC; Wu, HT; Yeh, CH | 1 |
| Hofmann, R | 1 |
| Ali, NW; Elghobashy, MR; Mahmoud, MG; Mohammed, MA | 1 |
| Calatayud, GA; Castrellón, PG; Cézard, JP; Chéron, G; Garcia, JM; Lehert, P; Santos, M; Savitha, MR | 1 |
| Chen, CT; Cheng, JT; Cheng, KC; Chung, HH; Lee, JP; Wu, HT | 1 |
| Cuello García, CA; Pacheco Alvarado, KP; Pérez Gaxiola, G | 1 |
| Calero, C; Gutiérrez, C; López-Campos, JL | 1 |
| Tack, J | 1 |
| Duh, D; Tanret, I | 1 |
| Meißner, W; Pastrana, T | 1 |
| Dharamsi, AT; Dhingani, AP; Garala, KC; Patel, JM | 1 |
| Jain, VK; Khandelwal, PD; Mehta, S; Sihag, M | 1 |
| Panchpuri, M; Semalty, A; Semalty, M; Singh, D | 1 |
| Leemans, L | 1 |
| Angoulvant, F; Gajdos, V; Julliand, S; Llor, J; Lorrot, M; Oostenbrink, R; Pelc, R; Redant, S | 1 |
| Heather, CS | 1 |
| Akobeng, A; Gordon, M | 1 |
| Cifuentes, L; Sáez, J | 1 |
| Arnett, SD; Bond, BR; Campbell, MA; Choy, RK; de Hostos, E; Griggs, DW; Ji, Y; Meyers, MJ; Neckermann, G; Oliva, J; Prinsen, MJ; Ruminski, PG; Tajfirouz, D; Yu, Y | 1 |
| Chiguru, V; Lingesh, A; N, S; R, S | 1 |
| Anbu, D; Bose, A; Kang, G; Parez, N; Sarkar, R; Sindhu, K; Srinivasan, R; Subashini, B; Svensson, L; Thuppal, SV; Venugopal, S | 1 |
| Ellis, D; Goldthorpe, J; Iglesias, N; Lazonby, G; Puntis, JW; Steele, J; Tran, LC; Vora, R; Zamvar, V | 1 |
| Haditsch, M; Jelinek, T; Nothdurft, HD; Weinke, T | 1 |
| Bui, T; Choy, RK; Glark-Deener, SG; Hualei, S; Kim, I; Li, G; Ramesh, AK; Twitchell, EL; Weiss, MD; Wen, K; Yang, X; Yuan, L | 1 |
| Bodmeier, R; Dashevskiy, A; Deng, J; Hao, S; Staufenbiel, S; Wang, B | 1 |
| Foroughbakhshfasaei, M; Noszál, B; Szabó, ZI; Tóth, G | 1 |
| Chen, M; Däbritz, J; Eberlin, M; Mueck, T | 1 |
| Gordon, M; Liang, Y; Wen, J; Zeng, L; Zhang, L | 1 |
| Benninga, MA; Broekaert, IJ; Dolinsek, J; Mas, E; Miele, E; Orel, R; Pienar, C; Ribes-Koninckx, C; Thapar, N; Thomassen, RA; Thomson, M; Tzivinikos, C | 1 |
| Huang, X; Li, L; Shen, C; Tang, L; Xue, S; Yu, Y; Zhou, Q | 1 |
| Chen, F; Luo, C; Wang, B; Wang, H; Wang, Y; Xiang, X; Yang, L | 1 |
| Eser Faki, H; Ider, M; Ok, M; Ozdemir Kutahya, Z; Parlak, TM; Tras, B; Uney, K; Yildiz, R | 1 |
| Assier, H; Ingen-Housz-Oro, S; Kechichian, E; Weill, A | 1 |
21 review(s) available for thiorphan and racecadotril
| Article | Year |
|---|---|
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency].
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Cyclic GMP; Diuresis; Female; Heart Failure; Humans; Male; Middle Aged; Natriuresis; Neprilysin; Thiorphan | 1991 |
Clinical potential of endopeptidase-24.11 inhibitors in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Cyclohexanecarboxylic Acids; Diuretics; Drug Design; Heart Failure; Humans; Hypertension; Indans; Neprilysin; Propionates; Protease Inhibitors; Thiorphan | 1993 |
Racecadotril: a new approach to the treatment of diarrhoea.
Topics: Animals; Antidiarrheals; Diarrhea; Dogs; Rats; Thiorphan | 2000 |
An overview of clinical studies with racecadotril in adults.
Topics: Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Humans; Randomized Controlled Trials as Topic; Thiorphan | 2000 |
Racecadotril.
Topics: Animals; Antidiarrheals; Humans; Thiorphan | 2000 |
Strategies for access to enantiomerically pure ecadotril, dexecadotril and fasidotril: a review.
Topics: Alanine; Chemistry, Pharmaceutical; Enzyme Inhibitors; Humans; Prodrugs; Stereoisomerism; Thiorphan | 2002 |
Racecadotril versus loperamide: antidiarrheal research revisited.
Topics: Adolescent; Adult; Antidiarrheals; Child; Child, Preschool; Controlled Clinical Trials as Topic; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infant; Loperamide; Male; Middle Aged; Severity of Illness Index; Thiorphan; Treatment Outcome | 2003 |
[Prevention and treatment of acute diarrhea in infants].
Topics: Acute Disease; Antidiarrheals; Breast Feeding; Dehydration; Diarrhea, Infantile; Fluid Therapy; Humans; Infant; Infant Formula; Lactose; Probiotics; Rotavirus Vaccines; Thiorphan | 2007 |
Systematic review: racecadotril in the treatment of acute diarrhoea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Diarrhea; Female; Gastroenteritis; Humans; Infant; Male; Randomized Controlled Trials as Topic; Thiorphan; Treatment Outcome | 2007 |
Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril.
Topics: Acute Disease; Antidiarrheals; Bacterial Infections; Breast Feeding; Child; Dehydration; Diarrhea; Fluid Therapy; Humans; Malabsorption Syndromes; Thiorphan; Virus Diseases | 2008 |
[Systematic review of the efficacy of racecadotril in the treatment of acute diarrhoea].
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Diarrhea, Infantile; Humans; Infant; Randomized Controlled Trials as Topic; Thiorphan | 2008 |
Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis.
Topics: Adolescent; Adult; Antidiarrheals; Child; Combined Modality Therapy; Dehydration; Diarrhea; Feces; Female; Gastroenteritis; Humans; Male; Randomized Controlled Trials as Topic; Rehydration Solutions; Rotavirus; Thiorphan; Young Adult | 2011 |
Functional diarrhea.
Topics: Antidepressive Agents, Tricyclic; Antidiarrheals; Bismuth; Carbon; Cholestyramine Resin; Chronic Disease; Clonidine; Diarrhea; Humans; Octreotide; Organometallic Compounds; Oxides; Probiotics; Receptors, Opioid; Salicylates; Serotonin 5-HT3 Receptor Antagonists; Thiorphan | 2012 |
[Treatment of diarrhea with loperamide in palliative medicine. A systematic review].
Topics: Acquired Immunodeficiency Syndrome; Antidiarrheals; Controlled Clinical Trials as Topic; Diarrhea; Diphenoxylate; Drug Therapy, Combination; Humans; Loperamide; Octreotide; Palliative Care; Thiorphan | 2013 |
What place for ▾racecadotril?
Topics: Antidiarrheals; Diarrhea; Humans; Neprilysin; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Thiorphan; United Kingdom; World Health Organization | 2013 |
[The treatment of acute diarrhea].
Topics: Adult; Anti-Bacterial Agents; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Loperamide; Probiotics; Thiorphan | 2013 |
Travellers' diarrhoea.
Topics: Anti-Bacterial Agents; Antidiarrheals; Bismuth; Diarrhea; Diet; Fluid Therapy; Humans; Organometallic Compounds; Salicylates; Thiorphan; Travel-Related Illness | 2015 |
Racecadotril for acute diarrhoea in children: systematic review and meta-analyses.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Thiorphan; Treatment Outcome | 2016 |
Is racecadotril effective for acute diarrhea in children? -First update.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trials as Topic; Thiorphan; Time Factors; Treatment Outcome | 2015 |
Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Randomized Controlled Trials as Topic; Thiorphan | 2018 |
Racecadotril for acute diarrhoea in children.
Topics: Child, Preschool; Diarrhea; Fluid Therapy; Humans; Infant; Length of Stay; Randomized Controlled Trials as Topic; Thiorphan; Treatment Outcome | 2019 |
37 trial(s) available for thiorphan and racecadotril
| Article | Year |
|---|---|
Effects of acetorphan, an antidiarrhoeal enkephalinase inhibitor, on oro-caecal and colonic transit times in healthy volunteers.
Topics: Adult; Double-Blind Method; Feasibility Studies; Gastrointestinal Motility; Humans; Male; Sulfapyridine; Sulfasalazine; Thiorphan | 1992 |
Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Neprilysin; Skin; Substance P; Sulfites; Thiorphan | 1992 |
Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Castor Oil; Diarrhea; Double-Blind Method; Female; Humans; Male; Middle Aged; Neprilysin; Thiorphan; Time Factors | 1992 |
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency].
Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Cyclic GMP; Diuresis; Female; Heart Failure; Humans; Male; Middle Aged; Natriuresis; Neprilysin; Thiorphan | 1991 |
Effect of sinorphan, an enkephalinase inhibitor, on plasma atrial natriuretic factor and sodium urinary excretion in cirrhotic patients with ascites.
Topics: Administration, Oral; Adult; Aldosterone; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Liver Cirrhosis; Male; Middle Aged; Neprilysin; Renin; Sodium; Thiorphan | 1991 |
Effect of sinorphan on plasma atrial natriuretic factor in congestive heart failure.
Topics: Administration, Oral; Atrial Natriuretic Factor; Clinical Trials as Topic; Drug Administration Schedule; Heart Failure; Humans; Male; Neprilysin; Stimulation, Chemical; Thiorphan | 1990 |
Antihypertensive activity of sinorphan.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Female; Humans; Hypertension; Male; Middle Aged; Thiorphan | 1990 |
Comparison of acetorphan with clonidine for opiate withdrawal symptoms.
Topics: Adolescent; Adult; Clonidine; Double-Blind Method; Female; Heroin; Humans; Male; Narcotics; Neprilysin; Opioid-Related Disorders; Substance Withdrawal Syndrome; Thiorphan | 1991 |
Stereoselective protection of exogenous and endogenous atrial natriuretic factor by enkephalinase inhibitors in mice and humans.
Topics: Administration, Oral; Adult; Animals; Atrial Natriuretic Factor; Binding, Competitive; Chemical Phenomena; Chemistry; Cyclic GMP; Double-Blind Method; Humans; Injections, Intravenous; Kidney; Male; Mice; Neprilysin; Random Allocation; Thiorphan; Time Factors | 1990 |
Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC 3.4.24.11) by acetorphan.
Topics: Animals; Atrial Natriuretic Factor; Diuresis; Humans; Hydrolysis; Kidney; Kinetics; Male; Mice; Natriuresis; Neprilysin; Thiorphan | 1989 |
[Acetorphan, a potent enkephalinase inhibitor, does not modify orocecal and colonic transit times in healthy subjects].
Topics: Adult; Analgesics; Enzyme Inhibitors; Gastrointestinal Transit; Humans; Male; Thiorphan | 1989 |
Effects of an enkephalinase inhibitor on esophageal motility in man.
Topics: Enkephalins; Esophagogastric Junction; Esophagus; Humans; Manometry; Neprilysin; Peristalsis; Random Allocation; Thiorphan | 1988 |
Role of neutral endopeptidase and kininase II on substance P-induced increase in nasal obstruction in patients with allergic rhinitis.
Topics: Administration, Intranasal; Administration, Oral; Adult; Airway Resistance; Analysis of Variance; Cilazapril; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Humans; Male; Nasal Obstruction; Nasal Provocation Tests; Neprilysin; Peptidyl-Dipeptidase A; Rhinitis, Allergic, Perennial; Substance P; Thiorphan | 1994 |
Neutral endopeptidase versus angiotensin converting enzyme inhibition in essential hypertension.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Captopril; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Neprilysin; Protease Inhibitors; Thiorphan | 1995 |
[Treatment of acute chemically induced diarrhea by inhibition of enkephalinase. Results of a pilot study].
Topics: Acute Disease; Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Combined Modality Therapy; Diarrhea; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neprilysin; Prospective Studies; Thiorphan | 1995 |
Inhibition of neutral endopeptidase stimulates renal sodium excretion in patients with chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Atrial Natriuretic Factor; Cyclic GMP; Double-Blind Method; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Neprilysin; Sodium; Sodium, Dietary; Thiorphan; Time Factors | 1993 |
The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide.
Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; Thiorphan | 1993 |
Treatment of refractory diarrhoea in AIDS with acetorphan and octreotide: a randomized crossover study.
Topics: Adult; Antidiarrheals; Cross-Over Studies; Gastrointestinal Agents; HIV Enteropathy; Humans; Male; Middle Aged; Octreotide; Protease Inhibitors; Thiorphan | 1996 |
Lack of efficacy of neutral endopeptidase inhibitor ecadotril in heart failure. The International Ecadotril Multi-centre Dose-ranging Study Investigators.
Topics: Anemia, Aplastic; Dose-Response Relationship, Drug; Female; Heart Failure; Humans; Male; Middle Aged; Neprilysin; Protease Inhibitors; Thiorphan | 1998 |
Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment.
Topics: Adult; Aged; Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Diarrhea; Female; Humans; Irinotecan; Loperamide; Male; Middle Aged; Prospective Studies; Thiorphan | 1998 |
A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: the U.S. ecadotril pilot safety study.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Pilot Projects; Prodrugs; Severity of Illness Index; Thiorphan; Time Factors; Treatment Outcome | 1999 |
Racecadotril versus placebo in the treatment of acute diarrhoea in adults.
Topics: Acute Disease; Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Female; Humans; Male; Middle Aged; Neprilysin; Protease Inhibitors; Thiorphan | 1999 |
Comparison of racecadotril and loperamide in adults with acute diarrhoea.
Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; Protease Inhibitors; Thiorphan | 1999 |
Comparison of racecadotril and loperamide in children with acute diarrhoea.
Topics: Acute Disease; Antidiarrheals; Child; Child, Preschool; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; Protease Inhibitors; Recurrence; Thiorphan | 1999 |
Racecadotril in the treatment of acute watery diarrhea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Combined Modality Therapy; Developing Countries; Diarrhea; Double-Blind Method; Feces; Fluid Therapy; Hospitalization; Humans; Infant; Male; Neprilysin; Rotavirus; Thiorphan; Time Factors | 2000 |
Prognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure. CPT-11 F205, F220, F221 and V222 study groups.
Topics: Adult; Aged; Antidiarrheals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Diarrhea; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Neoplasm Metastasis; Neutropenia; Predictive Value of Tests; Randomized Controlled Trials as Topic; Risk Factors; Thiorphan | 2000 |
Efficacy and tolerability of racecadotril in acute diarrhea in children.
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Defecation; Diarrhea; Double-Blind Method; Female; Humans; Infant; Male; Thiorphan; Time Factors | 2001 |
A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.
Topics: Acute Disease; Administration, Oral; Adult; Antidiarrheals; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; International Cooperation; Loperamide; Male; Middle Aged; Multivariate Analysis; Probability; Single-Blind Method; Thiorphan; Treatment Outcome | 2002 |
Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients.
Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclosporine; Double-Blind Method; Endothelin-1; Glomerular Filtration Rate; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Natriuresis; Neprilysin; Protease Inhibitors; Renal Circulation; Thiorphan; Vascular Resistance | 2002 |
[Effect of racecadotril in the management of acute diarrhea in infants and children].
Topics: Acute Disease; Antidiarrheals; Child, Preschool; Dehydration; Diarrhea; Emergency Medical Services; Female; Fluid Therapy; Humans; Infant; Male; Thiorphan; Treatment Outcome; Water-Electrolyte Balance | 2002 |
Efficacy and tolerability of racecadotril in the treatment of cholera in adults: a double blind, randomised, controlled clinical trial.
Topics: Acute Disease; Adolescent; Adult; Antidiarrheals; Chemotherapy, Adjuvant; Chi-Square Distribution; Cholera; Double-Blind Method; Humans; Male; Middle Aged; Statistics, Nonparametric; Thiorphan; Vibrio cholerae | 2003 |
A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
Topics: Acute Disease; Adult; Antidiarrheals; Constipation; Diarrhea; Female; Humans; Loperamide; Male; Middle Aged; Pruritus; Single-Blind Method; Thiorphan; Treatment Outcome | 2005 |
Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study.
Topics: Acute Disease; Ambulatory Care; Antidiarrheals; Dehydration; Diarrhea; Drug Therapy, Combination; Emergency Service, Hospital; Female; Gastroenteritis; Humans; Infant; Male; Prospective Studies; Rehydration Solutions; Thiorphan | 2009 |
Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes.
Topics: Abdominal Pain; Aged; Aged, 80 and over; Aging; Antidiarrheals; Cytochrome P-450 Enzyme System; Dehydration; Diarrhea; Double-Blind Method; Female; Gastroenteritis; Homes for the Aged; Humans; Loperamide; Male; Nursing Homes; Polymorphism, Genetic; Statistics as Topic; Thiorphan | 2010 |
Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems.
Topics: Adult; Antidiarrheals; Attitude of Health Personnel; Child; Decision Making; Diarrhea; Evidence-Based Medicine; Female; Guideline Adherence; Humans; Male; Mexico; Middle Aged; Pediatrics; Practice Guidelines as Topic; Professional Practice; Thiorphan | 2011 |
A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antidiarrheals; Diarrhea; Drug Therapy, Combination; Dysentery; Female; Fluid Therapy; Humans; Male; Middle Aged; Octreotide; Thiorphan; Treatment Outcome; Young Adult | 2012 |
Racecadotril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials.
Topics: Antidiarrheals; Child, Preschool; Diarrhea; Female; Humans; Infant; Male; Rotavirus Infections; Thiorphan | 2016 |
93 other study(ies) available for thiorphan and racecadotril
| Article | Year |
|---|---|
Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Multidrug Resistance-Associated Proteins; Orphan Drug Production; Paclitaxel; RNA Stability; RNA, Messenger; Structure-Activity Relationship; Tiopronin | 2011 |
Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.
Topics: Aminopeptidases; Analgesia; Animals; Binding Sites; Brain; CD13 Antigens; Chromatography, High Pressure Liquid; Disulfides; Kidney; Methionine; Mice; Molecular Structure; Pain Measurement; Prodrugs; Structure-Activity Relationship; Sulfhydryl Compounds; Swine; Thiorphan | 1992 |
The effects of orally active enkephalinase inhibitors on morphine withdrawal syndrome.
Topics: Administration, Oral; Analgesics; Animals; Dioxolanes; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Morphine; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Wistar; Stereotyped Behavior; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Desensitization of mu-opioid receptors does not modify the analgesia induced by an enkephalinase inhibitor.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Neprilysin; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan | 1991 |
Effects of aerosolised substance P on lung resistance in guinea-pigs: a comparison between inhibition of neutral endopeptidase and angiotensin-converting enzyme.
Topics: Acetylcholine; Aerosols; Airway Resistance; Analgesics; Animals; Endopeptidases; Guinea Pigs; Lung; Male; Peptidyl-Dipeptidase A; Propranolol; Substance P; Thiorphan | 1990 |
Chronic inhibition of enkephalinase induces changes in the antinociceptive and locomotor effects of the enkephalinase inhibitor acetorphan in rats.
Topics: Amino Acid Sequence; Analgesics; Animals; Corpus Striatum; Injections, Intravenous; Injections, Intraventricular; Male; Molecular Sequence Data; Motor Activity; Neprilysin; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Thiorphan | 1991 |
[Clinical significance and therapeutic application of atrial natriuretic peptides].
Topics: Animals; Atrial Natriuretic Factor; Glycopeptides; Heart Atria; Heart Failure; Hemodynamics; Humans; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Thiorphan | 1991 |
Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril.
Topics: Alanine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Cell Membrane; Cyclic GMP; Dioxoles; Dipeptides; Diuresis; Glycine; Humans; Lung; Male; Mice; Molecular Structure; Natriuresis; Neprilysin; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Strains; Thiorphan | 1991 |
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan | 1990 |
[Enkephelinase inhibitors acetorphan and SCH34826 potentiate the analgesic effect of low frequency electroacupuncture in rats].
Topics: Acupuncture Analgesia; Animals; Dioxolanes; Dipeptides; Electroacupuncture; Female; Male; Neprilysin; Pain; Rats; Sensory Thresholds; Thiorphan | 1990 |
Inactivation of atrial natriuretic factor in mice in vivo: crucial role of enkephalinase (EC 3.4.24.11).
Topics: Administration, Oral; Animals; Atrial Natriuretic Factor; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Iodine Radioisotopes; Kidney; Male; Mice; Neprilysin; Protease Inhibitors; Thiorphan; Time Factors | 1990 |
Diuretic and natriuretic responses in rats treated with enkephalinase inhibitors.
Topics: Animals; Atrial Natriuretic Factor; Chromatography, High Pressure Liquid; Diuresis; Injections, Intravenous; Male; Natriuresis; Neprilysin; Potassium; Prodrugs; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Thiorphan; Time Factors | 1990 |
Degradation of atrial natriuretic factor in mouse blood in vitro and in vivo: role of enkephalinase (EC 3.4.24.11).
Topics: Animals; Atrial Natriuretic Factor; Chromatography, High Pressure Liquid; Half-Life; Hydrolysis; In Vitro Techniques; Iodine Radioisotopes; Male; Metabolic Clearance Rate; Mice; Neprilysin; Thiorphan | 1990 |
Penicillins exhibit enkephalinase inhibitory activity in mice.
Topics: Ampicillin; Analgesics; Animals; Carfecillin; Cloxacillin; Male; Mice; Neprilysin; Nociceptors; Penicillins; Thiorphan | 1990 |
Non-cholinergic neural excitation of the human rectum induced by acetorphan, an inhibitor of enkephalinase.
Topics: Adult; Analgesics; Electromyography; Enkephalins; Female; Hirschsprung Disease; Humans; Male; Neprilysin; Rectum; Stimulation, Chemical; Thiorphan | 1989 |
Assessment of the abuse potential of acetorphan, an enkephalinase inhibitor.
Topics: Animals; Cocaine; Discrimination, Psychological; Female; Macaca mulatta; Male; Morphine Dependence; Neprilysin; Rats; Rats, Inbred Strains; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiorphan | 1989 |
Augmented analgesic effects of enkephalinase inhibitors combined with transcranial electrostimulation.
Topics: Analgesia; Analgesics; Animals; Brain; Cerebral Ventricles; Electric Stimulation; Injections, Intraventricular; Male; Neprilysin; Pain; Rats; Rats, Inbred Strains; Reference Values; Thiorphan | 1989 |
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Pain; Protease Inhibitors; Reference Values; Species Specificity; Thiorphan | 1989 |
Naloxone-reversible inhibition of gall-bladder mucosal fluid secretion in experimental cholecystitis in the cat by acetorphan, an enkephalinase inhibitor.
Topics: Animals; Bile; Cats; Cholecystitis; Gallbladder; Mucous Membrane; Naloxone; Neprilysin; Thiorphan | 1989 |
In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF.
Topics: Amino Acids, Sulfur; Endopeptidases; Humans; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Thiorphan; Tiopronin | 1986 |
Role of endogenous enkephalins in locomotion evidenced by acetorphan, an "enkephalinase" inhibitor.
Topics: Amino Acids, Sulfur; Animals; Dose-Response Relationship, Drug; Enkephalins; Hydroxydopamines; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thiorphan; Tiopronin | 1987 |
Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Body Temperature; Body Weight; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1988 |
Influence of enkephalinase inhibitors on gastric emptying in mice depends on the nature of the meal.
Topics: Amino Acids, Sulfur; Animals; Dietary Fats; Enkephalin, Methionine; Gastric Emptying; Male; Mice; Thiorphan; Tiopronin | 1988 |
Evaluation of enkephalinase inhibition in the living mouse, using [3H]acetorphan as a probe.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Dipeptides; Kidney; Kinetics; Lung; Membranes; Mice; Neprilysin; Prodrugs; Thiorphan | 1988 |
Thiorphan and acetorphan inhibit gastric secretion by a central, non-opioid mechanism in the rat.
Topics: Animals; Drug Interactions; Enkephalin, Methionine; Gastric Acid; Gastric Mucosa; Male; Neprilysin; Pentagastrin; Prodrugs; Rats; Rats, Inbred Strains; Thiorphan | 1988 |
Origin of the stimulation of food intake by oral administration of enkephalinase inhibitors in sheep.
Topics: Administration, Oral; Amino Acids, Sulfur; Analgesics; Animals; Appetite; Cerebral Ventricles; Endopeptidases; Female; Injections, Intravenous; Injections, Intraventricular; Neprilysin; Protease Inhibitors; Sheep; Thiorphan; Tiopronin | 1987 |
Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord.
Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Methionine; Leucine; Male; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1986 |
Enantiomers of thiorphan and acetorphan: correlation between enkephalinase inhibition, protection of endogenous enkephalins and behavioral effects.
Topics: Amino Acids, Sulfur; Analgesia; Angiotensin-Converting Enzyme Inhibitors; Animals; Corpus Striatum; Enkephalins; Globus Pallidus; In Vitro Techniques; Male; Metalloendopeptidases; Mice; Motor Activity; Neprilysin; Rats; Rats, Inbred Strains; Stereoisomerism; Thermolysin; Thiorphan; Tiopronin | 1987 |
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors.
Topics: Amino Acids, Sulfur; Animals; Castor Oil; Diarrhea; Drug Interactions; Gastrointestinal Transit; Loperamide; Male; Metalloendopeptidases; Mice; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1987 |
Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Antidiarrheals; Biogenic Amines; Brain Chemistry; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Injections; Kinetics; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1986 |
Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue, [D-Ala2-Met5]-enkephalinamide, on uterine motility in periparturient rats in vivo and in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Naloxone; Narcotic Antagonists; Neprilysin; Neurotransmitter Agents; Pregnancy; Protease Inhibitors; Rats; Rats, Wistar; Stimulation, Chemical; Thiorphan; Uterine Contraction | 1995 |
Acute renal effects of neutral endopeptidase inhibition in humans.
Topics: Blood Pressure; Dextrans; Electrolytes; Female; Glomerular Filtration Rate; Hemodynamics; Hormones; Humans; Kidney; Male; Neprilysin; Renal Circulation; Thiorphan; Time Factors | 1994 |
Prolonged inhibition of neutral endopeptidase 24.11 by sinorphan in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Heart Failure; Hemodynamics; Kidney Function Tests; Neprilysin; Rats; Rats, Inbred SHR; Sodium, Dietary; Thiorphan; Time Factors | 1995 |
A new enkephalinase inhibitor as an alternative to loperamide in the prevention of diarrhea induced by CPT-11.
Topics: Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Diarrhea; Female; Humans; Irinotecan; Loperamide; Male; Middle Aged; Neprilysin; Randomized Controlled Trials as Topic; Thiorphan | 1995 |
Locomotor and analgesic effects of morphine and acetorphan in rats chronically treated with morphine or thiorphan.
Topics: Analgesics; Animals; Drug Tolerance; Injections, Intraventricular; Male; Morphine; Motor Activity; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiorphan | 1994 |
Analgesic potency of S-acetylthiorphan after intravenous administration to mice.
Topics: Analgesics; Animals; Injections, Intravenous; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Thiorphan | 1993 |
Action of enkephalinase (EC 3.4.24.11) inhibition on the pre- and post-prandial electromyographic patterns of colon in rats.
Topics: Animals; Cecum; Colon; Eating; Electromyography; Endorphins; Gastrointestinal Motility; Male; Membrane Proteins; Naloxone; Neprilysin; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 1993 |
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Dipeptides; Magnetic Resonance Spectroscopy; Male; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfhydryl Compounds; Thiorphan; Tryptophan | 1995 |
Role of neutral endopeptidase 24.11 in AV fistular rat model of heart failure.
Topics: Angiotensin I; Animals; Aorta; Arteriovenous Fistula; Atrial Natriuretic Factor; Disease Models, Animal; Heart Failure; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Renin; Sodium; Thiorphan; Venae Cavae | 1996 |
Renal and antihypertensive effects of neutral endopeptidase inhibition in transgenic rats with an extra renin gene.
Topics: Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Hormones; Kidney; Male; Mice; Neprilysin; Prodrugs; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Renin; Thiorphan | 1996 |
A C-terminal cyclic 8-13 neurotensin fragment analog appears less exposed to neprilysin when it crosses the blood-brain barrier than the cerebrospinal fluid-brain barrier in mice.
Topics: Animals; Blood-Brain Barrier; Body Temperature Regulation; Brain; Cerebrospinal Fluid; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Neprilysin; Neurotensin; Peptide Fragments; Prodrugs; Protease Inhibitors; Receptors, Neurotensin; Thiorphan | 1996 |
Acetorphan prevents cholera-toxin-induced water and electrolyte secretion in the human jejunum.
Topics: Adult; Cholera Toxin; Electrolytes; Female; Humans; Ion Transport; Jejunum; Male; Protease Inhibitors; Thiorphan; Water | 1997 |
Effect of ecadotril, a neutral endopeptidase inhibitor, on myocardial hypertrophy in the rat aortic insufficiency model.
Topics: Angiotensin II; Animals; Aortic Diseases; Blood Pressure; Cardiomegaly; Disease Models, Animal; Guanosine Monophosphate; Male; Protease Inhibitors; Rats; Rats, Wistar; Thiorphan | 1998 |
The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds.
Topics: Abdominal Muscles; Acetic Acid; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclobutanes; Dothiepin; Male; Maprotiline; Mice; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Neurotransmitter Uptake Inhibitors; Opioid Peptides; Pain Measurement; Paroxetine; Protease Inhibitors; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors; Thiorphan | 1998 |
Cholecystokinin receptor agonists block the jumping behaviour precipitated in morphine-dependent mice by naloxone.
Topics: Animals; Ceruletide; Devazepide; Dose-Response Relationship, Drug; Hormone Antagonists; Male; Mice; Morphine Dependence; Motor Activity; Naloxone; Narcotic Antagonists; Pyrazoles; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Tetragastrin; Thiorphan | 1999 |
Interaction between neutral endopeptidase and angiotensin converting enzyme inhibition in rats with myocardial infarction: effects on cardiac hypertrophy and angiotensin and bradykinin peptide levels.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Bradykinin; Cardiomegaly; Cyclic GMP; Drug Synergism; Indoles; Male; Myocardial Infarction; Neprilysin; Peptidyl-Dipeptidase A; Perindopril; Potassium; Protease Inhibitors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Renin; Sodium; Thiorphan | 1999 |
Effect of prolonged administration of a urinary kinase inhibitor, ebelactone B on the development of deoxycorticosterone acetate-salt hypertension in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Carboxypeptidases; Cathepsin A; Desoxycorticosterone; Drinking; Heart; Heart Ventricles; Hypertension; Kallikreins; Kidney; Kinins; Lactones; Lisinopril; Male; Organ Size; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Thiorphan; Time Factors; Urination; Water-Electrolyte Balance | 1999 |
Ecadotril. (S)-acetorphan, sinorphan.
Topics: Animals; Cardiovascular Diseases; Drugs, Investigational; Endopeptidases; Heart Failure; Humans; Hypertension; Protease Inhibitors; Rats; Rats, Inbred SHR; Thiorphan | 1999 |
Introduction. Enkephalinase inhibition: a rational approach to antisecretory therapy for acute diarrhoea.
Topics: Acute Disease; Antidiarrheals; Diarrhea; Humans; Neprilysin; Protease Inhibitors; Thiorphan | 1999 |
Racecadotril demonstrates intestinal antisecretory activity in vivo.
Topics: Animals; Antidiarrheals; Cholera Toxin; Dogs; Intestinal Mucosa; Naloxone; Neprilysin; Phentolamine; Protease Inhibitors; Thiorphan | 1999 |
Effects of racecadotril and loperamide on bacterial proliferation and on the central nervous system of the newborn gnotobiotic piglet.
Topics: Animals; Animals, Newborn; Antidiarrheals; Bacteria; Brain; Digestive System; Germ-Free Life; Loperamide; Neprilysin; Protease Inhibitors; Swine; Thiorphan | 1999 |
Short-term effects of ecadotril in dogs with induced congestive heart failure.
Topics: Animals; Cyclic GMP; Dog Diseases; Dogs; Electrocardiography; Heart Failure; Hemodynamics; Male; Microspheres; Potassium; Protease Inhibitors; Random Allocation; Sodium; Thiorphan | 2000 |
Acute, subchronic, and chronic toxicity of ecadotril in dogs.
Topics: Animals; Dog Diseases; Dogs; Drug Administration Schedule; Heart Failure; Neprilysin; Prodrugs; Protease Inhibitors; Thiorphan | 2000 |
Intrarenal effects of ecadotril during acute volume expansion in dogs with congestive heart failure.
Topics: Animals; Atrial Natriuretic Factor; Dogs; Glomerular Filtration Rate; Heart Failure; Kidney; Male; Neprilysin; Protease Inhibitors; Renal Circulation; Thiorphan | 2000 |
Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension.
Topics: Animals; Blood Pressure; Blotting, Southern; Cyclosporine; DNA Probes; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Natriuretic Peptide, C-Type; Neprilysin; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Protease Inhibitors; Rats; Rats, Inbred WKY; RNA, Messenger; Thiorphan | 2000 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
Effects of chronic neutral endopeptidase inhibition on the progression of left ventricular dysfunction and remodeling in dogs with moderate heart failure.
Topics: Animals; Chronic Disease; Coronary Angiography; Dogs; Heart Failure; Hemodynamics; Myocytes, Cardiac; Neprilysin; Thiorphan; Ventricular Dysfunction, Left; Ventricular Remodeling | 2002 |
Racecadotril (acetorphan) in the treatment of acute watery diarrhoea in children.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Thiorphan | 2002 |
The effect of acute angiotensin-converting enzyme and neutral endopeptidase 24.11 inhibition on plasma extravasation in the rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; Dose-Response Relationship, Drug; Lung; Male; Neprilysin; Peptidyl-Dipeptidase A; Plasma; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Thiorphan | 2004 |
Racecadotril-is there enough evidence to recommend it for treatment of acute diarrhea?
Topics: Antidiarrheals; Diarrhea; Humans; Thiorphan; Treatment Outcome | 2004 |
Raacecadotril.
Topics: Antidiarrheals; Humans; Thiorphan; Treatment Outcome | 2004 |
Racecadotril in acute diarrhea.
Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Drug Evaluation; Female; Humans; Male; Research Design; Thiorphan | 2005 |
Hypersensitivity to racecadotril: a case report.
Topics: Antidiarrheals; Child, Preschool; Drug Hypersensitivity; Female; Humans; Neprilysin; Thiorphan | 2006 |
Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea.
Topics: Acute Disease; Antidiarrheals; Antiparasitic Agents; Child; Child, Preschool; Cholera; Diarrhea; Disease Outbreaks; Dysentery, Bacillary; Female; Humans; Infant; Intestinal Diseases, Parasitic; Male; Nitro Compounds; Probiotics; Thiazoles; Thiorphan | 2006 |
Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography/tandem mass spectrometry.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Neprilysin; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Thiorphan | 2007 |
Structural studies of racecadotril and its process impurities by NMR and mass spectroscopy.
Topics: Chromatography, High Pressure Liquid; Drug Contamination; Magnetic Resonance Spectroscopy; Mass Spectrometry; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thiorphan | 2006 |
A rapid and validated HPLC method to quantify racecadotril metabolite, thiorphan, in human plasma using solid-phase extraction.
Topics: Chromatography, High Pressure Liquid; Humans; Molecular Structure; Reproducibility of Results; Solid Phase Extraction; Thiorphan | 2008 |
The characterization of selected drugs with infrared laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry.
Topics: Antihypertensive Agents; Captopril; Cystine; Infrared Rays; Pharmaceutical Preparations; Photochemistry; Protease Inhibitors; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Synchrotrons; Thiorphan; Ultraviolet Rays; Vacuum | 2008 |
Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Atrial Natriuretic Factor; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Hypertension, Pulmonary; Male; Neprilysin; Piperazines; Protease Inhibitors; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Thiorphan; Treatment Outcome; Vascular Resistance; Vasodilation; Vasodilator Agents | 2008 |
Colon in acute intestinal infection.
Topics: Acute Disease; Antidiarrheals; Caco-2 Cells; Colon; Diarrhea; Drug Evaluation, Preclinical; Gastroenteritis; Humans; Intestinal Absorption; Rotavirus Infections; Thiorphan; Zinc | 2009 |
Stability-indicating methods for the determination of racecadotril in the presence of its degradation products.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Molecular Structure; Spectrophotometry, Ultraviolet; Thiorphan | 2009 |
Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Blood Glucose; Brain; C-Peptide; Cell Line; Cell Separation; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Enkephalins; Hemicholinium 3; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Muscarinic Antagonists; Neprilysin; Physostigmine; Rats; Rats, Wistar; Receptors, Muscarinic; Thiorphan | 2010 |
Remarks and questions on the article "Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes".
Topics: Aged; Antidiarrheals; Double-Blind Method; Female; Gastroenteritis; Homes for the Aged; Humans; Loperamide; Male; Nursing Homes; Randomized Controlled Trials as Topic; Thiorphan; Treatment Outcome | 2010 |
Spectrophotometric and spectrofluorimetric methods for determination of Racecadotril.
Topics: Antidiarrheals; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Iron; Iron Chelating Agents; Phenanthrolines; Powders; Reference Standards; Reproducibility of Results; Solutions; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiorphan | 2011 |
Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats.
Topics: Animals; Antibodies; Blood Glucose; Brain; Glyburide; Injections, Intravenous; Injections, Intraventricular; Insulin; Insulysin; KATP Channels; Male; Rats; Rats, Wistar; Thiorphan; Tissue Extracts; Vagotomy; Vagus Nerve | 2011 |
The potential role of racecadotril in the treatment of diarrhea associated with roflumilast.
Topics: Adrenergic beta-2 Receptor Agonists; Adult; Aminopyridines; Antidiarrheals; Benzamides; Child; Cyclic AMP; Cyclopropanes; Diarrhea; Humans; Neprilysin; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Thiorphan | 2012 |
[Racecadotril (Tiorfix), oral].
Topics: Adult; Antidiarrheals; Child; Child, Preschool; Diarrhea; Drug Interactions; Humans; Infant; Infant, Newborn; Thiorphan | 2012 |
Preparation and evaluation of agglomerated crystals by crystallo-co-agglomeration: an integrated approach of principal component analysis and Box-Behnken experimental design.
Topics: Antidiarrheals; Cluster Analysis; Crystallization; Drug Compounding; Excipients; Hypromellose Derivatives; Methylcellulose; Polyethylene Glycols; Polyvinyl Alcohol; Principal Component Analysis; Research Design; Solubility; Solvents; Talc; Tensile Strength; Thiorphan | 2013 |
Cyclodextrin inclusion complex of racecadotril: effect of drug-β- cyclodextrin ratio and the method of complexation.
Topics: Antidiarrheals; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Microscopy, Electron, Scanning; Powder Diffraction; Solubility; Spectroscopy, Fourier Transform Infrared; Thiorphan; X-Ray Diffraction | 2014 |
Pediatric gastroenteritis in the emergency department: practice evaluation in Belgium, France, The Netherlands and Switzerland.
Topics: Abdomen; Antidiarrheals; Antiemetics; Belgium; Blood Cell Count; Blood Gas Analysis; C-Reactive Protein; Cross-Sectional Studies; Dehydration; Electrolytes; Emergency Service, Hospital; Feces; Fluid Therapy; France; Gastroenteritis; Humans; Netherlands; Ondansetron; Practice Patterns, Physicians'; Probiotics; Surveys and Questionnaires; Switzerland; Thiorphan; Ultrasonography; Urinalysis | 2014 |
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.
Topics: Animals; Antidiarrheals; Castor Oil; Charcoal; Diarrhea; Dose-Response Relationship, Drug; Endopeptidases; Feces; Gastrointestinal Motility; Male; Protease Inhibitors; Rats; Rats, Wistar; Thiorphan | 2016 |
Forced degradation study of racecadotril: Effect of co-solvent, characterization of degradation products by UHPLC-Q-TOF-MS/MS, NMR and cytotoxicity assay.
Topics: Acetonitriles; Chromatography, High Pressure Liquid; Drug Stability; Formates; Hydrolysis; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Photolysis; Solvents; Tandem Mass Spectrometry; Thiorphan | 2016 |
Racecadotril + ACE inhibitors: angioedema.
Topics: Aged; Aged, 80 and over; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Drug Interactions; Female; Humans; Thiorphan | 2016 |
Racecadotril May Reduce Diarrhoea in Microvillous Inclusion Disease.
Topics: Antidiarrheals; Child, Preschool; Diarrhea; Humans; Malabsorption Syndromes; Male; Microvilli; Mucolipidoses; Thiorphan | 2017 |
[Consensus paper treatment of acute traveler's diarrhea. Practice recommendation for travel advice].
Topics: Anti-Bacterial Agents; Antidiarrheals; Consensus; Diarrhea; Dysentery; Germany; Humans; Practice Guidelines as Topic; Thiorphan; Travel | 2017 |
Effects of Racecadotril on Weight Loss and Diarrhea Due to Human Rotavirus in Neonatal Gnotobiotic Pigs (
Topics: Animals; Antidiarrheals; Diarrhea; Drug Evaluation, Preclinical; Rotavirus; Rotavirus Infections; Sus scrofa; Thiorphan; Weight Loss | 2017 |
Development of a discriminative biphasic in vitro dissolution test and correlation with in vivo pharmacokinetic studies for differently formulated racecadotril granules.
Topics: Animals; Chemistry, Pharmaceutical; Drug Liberation; Male; Models, Theoretical; Rats, Sprague-Dawley; Solubility; Thiorphan | 2017 |
Enantioseparation of racecadotril using polysaccharide-type chiral stationary phases in polar organic mode.
Topics: 2-Propanol; Amylose; Carbamates; Chromatography, High Pressure Liquid; Molecular Structure; Phenylcarbamates; Polysaccharides; Solvents; Stereoisomerism; Thermodynamics; Thiorphan | 2018 |
Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease.
Topics: Antidiarrheals; Child; Diarrhea; Gastrointestinal Diseases; Humans; Pharmaceutical Preparations; Thiorphan | 2020 |
Determination of thiorphan, a racecadotril metabolite, in human plasma by LC-MS/MS and its application to a bioequivalence study in Chinese subjects
.
Topics: Area Under Curve; Biological Availability; Chromatography, Liquid; Cross-Over Studies; Humans; Protease Inhibitors; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Thiorphan | 2020 |
Development, In Vitro and In Vivo Evaluation of Racecadotril Orodispersible Films for Pediatric Use.
Topics: Acrylic Resins; Administration, Oral; Antidiarrheals; Calorimetry, Differential Scanning; Cellulose; Child; Dosage Forms; Excipients; Humans; Hypromellose Derivatives; In Vitro Techniques; Pediatrics; Polyvinyl Alcohol; Powders; Solubility; Solvents; Thiorphan; X-Ray Diffraction | 2021 |
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
Topics: Animals; Antidiarrheals; Cattle; Cattle Diseases; Cryptosporidiosis; Cryptosporidium; Diarrhea; Thiorphan | 2022 |
Cimetidine and racecadotril: Unusual culprit drugs of a severe cutaneous adverse reaction.
Topics: Cimetidine; Dermatitis, Allergic Contact; Drug Hypersensitivity Syndrome; Humans; Thiorphan | 2022 |