thiorphan has been researched along with phosphoramidon in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (16.33) | 18.7374 |
| 1990's | 59 (60.20) | 18.2507 |
| 2000's | 17 (17.35) | 29.6817 |
| 2010's | 5 (5.10) | 24.3611 |
| 2020's | 1 (1.02) | 2.80 |
| Authors | Studies |
|---|---|
| Bohacek, RS; McMartin, C | 1 |
| Clark, F; Diefenbacher, CG; Ghai, RD; Ksander, GM; Sakane, Y; Yuan, AM | 1 |
| Berg, MJ; Elliott, RL; Marks, N; Portoghese, PS | 1 |
| Bihovsky, R; Erhardt, PW; Levinson, BL; Loewi, RC; Polokoff, MA | 1 |
| Berry, C; Blanchard, L; De Lombaert, S; el-Chehabi, L; Erion, MD; Ghai, RD; Sakane, Y; Tan, J; Trapani, AJ | 1 |
| Berry, CJ; Fink, CA; Ghai, RD; Qiao, Y; Sakane, Y; Trapani, AJ | 1 |
| Blanchard, L; Chou, M; De Lombaert, S; Fitt, J; Hoyer, D; Jeng, AY; Marcopoulos, N; Moliterni, J; Satoh, Y; Savage, P; Simonsbergen, D; Stamford, LB; Tan, J; Trapani, AJ; Wallace, EM | 1 |
| Fustero, S; Lazzari, P; Olimpieri, F; Pani, L; Sanchez-Roselló, M; Tambaro, S; Volonterio, A; Zanda, M | 1 |
| Devi, LA; Fournié-Zaluski, MC; Gagnidze, K; Orng, SV; Ouimet, T; Poras, H; Roques, BP | 1 |
| Hughes, TK; Paemen, LR; Stefano, GB | 1 |
| Conlon, JM; Gao, XP; Koizumi, S; Mayhan, WG; Rennard, SI; Rubinstein, I; Yong, T | 1 |
| Auberger, P; Checler, F; Farahifar, D; Manie, S; Mari, B; Peyron, JF; Ponzio, G; Rossi, B | 1 |
| Braquet, P; Lagente, V; Mencia-Huerta, JM; Pons, F; Touvay, C | 1 |
| Budzik, GP; Dillon, TP; Opgenorth, TJ; Zaragoza, R | 1 |
| Casley, DJ; Haslanger, MF; Johnston, CI; Kanazawa, M; Sybertz, EJ | 1 |
| Opgenorth, TJ; Pollock, DM | 1 |
| Berry, C; Ghai, R; Sakane, Y; Schulz, R | 1 |
| Back, SA; Gorenstein, C | 1 |
| Baas, AA; Dzoljic, MM; Dzoljic, MR; Rupreht, J; Ukponmwan, OE; van den Berg, DJ | 1 |
| Banks, K; Martin, JG; Takubo, T | 1 |
| Lefebvre, RA; Smits, GJ | 1 |
| Chiyotani, A; Horii, S; Isono, K; Kanemura, T; Kobayashi, K; Sakai, N; Takeuchi, S; Takizawa, T; Tamaoki, J; Yamawaki, I | 1 |
| Hirata, Y | 1 |
| Ando, M; Araki, S; Honda, I; Kawano, O; Kohrogi, H; Yamaguchi, T | 1 |
| Cohen, RB; Dickinson, KE; Hedberg, A; Liu, EC; Tymiak, AA; Webb, ML | 1 |
| Berend, N; Breslin, AB; Kemsley, L; Panaretto, K; Peters, MJ | 1 |
| Fischer, A; Kummer, W | 1 |
| Farmer, SG; Togo, J | 1 |
| Borson, DB; Caughey, G; Corrales, R; Gold, M; Nadel, JA; Ramachandran, J; Varsano, S; Viro, N | 1 |
| Stimler-Gerard, NP | 1 |
| Borson, DB; Graf, PD; Kohrogi, H; Nadel, JA; Sekizawa, K | 1 |
| Borson, DB; Djokic, TD; Nadel, JA; Sekizawa, K | 1 |
| Borson, DB; Djokic, TD; Dusser, DJ; Graf, PD; Nadel, JA; Sekizawa, K | 1 |
| McMartin, C; McNeal, RB; Webb, RL; Yasay, GD; Zimmerman, MB | 1 |
| Cherniack, NS; Deal, EC; Haxhiu, MA; van Lunteren, E | 1 |
| Arock, M; Devillier, P; Gros, C; Guillosson, JJ; Schwartz, JC | 1 |
| Anderson, S; Brenner, BM; Gunning, M; Lafferty, HM; Silva, P; Zimmerman, MB | 1 |
| Ansell, J; Erion, MD; Jeng, AY | 1 |
| Aoki, K; Kajiwara, M; Oka, T | 1 |
| Dzoljic, MR | 1 |
| Borson, DB; Dusser, DJ; Graf, PD; Nadel, JA; Sekizawa, K | 1 |
| Fulcher, IS; Kenny, AJ; Matsas, R; Turner, AJ | 1 |
| Webb, DJ | 1 |
| Chiou, WJ; Opgenorth, TJ; Wu-Wong, JR | 1 |
| Aviv, R; Blumberg, S; Gurbanov, K; Hoffman, A; Winaver, J | 1 |
| Bernard, E; Hornebeck, W; Robert, L | 1 |
| Balwierczak, JL; Jeng, AY; Kukkola, PJ; Savage, P | 1 |
| Battistini, B; Brown, M; Vane, JR | 1 |
| Eglezos, A; Mattera, GG; Mizrahi, J; Renzetti, AR | 1 |
| Balwierczak, JL; Graybill, SC; Hopkins, MF; Jeng, AY; Lappe, RW; Savage, P; Sperbeck, DM; Stanton, JL; Trapani, AJ | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Ando, M; Honda, I; Kawano, O; Kohrogi, H; Yamaguchi, T | 1 |
| Goto, K; Kimura, S; Kishi, N; Masaki, T; Sawamura, T; Shinmi, O; Sugita, Y; Yanagisawa, M | 1 |
| Bawab, W; Crine, P; Fournié-Zaluski, MC; Landry, C; Roques, BP; Santagata, P; Vinay, P | 1 |
| D'Orléans-Juste, P; Fournier, A; Lebel, N; Sirois, P | 2 |
| D'Orléans-Juste, P; Laporte, J; Sirois, P | 1 |
| Barnes, K; Shimada, K; Takahashi, M; Tanzawa, K; Turner, AJ | 1 |
| Gao, XP; Olopade, CO; Rubinstein, I; Suzuki, H | 1 |
| Kovaleva, ES; Masler, EP; Wagner, RM | 1 |
| Ahn, K; Guy, PM; Pan, SM; Sisneros, AM; Zientek, MA | 1 |
| Chakir, M; D'Orléans-Juste, P; Plante, GE | 1 |
| Anthes, J; Chapman, RW; Egan, RW; Greenfeder, S; Hey, JA; Kreutner, W; Mauser, PJ; Rasquinha, C; Sherwood, JE | 1 |
| Laporte, J; Sirois, P | 1 |
| Held, HD; Raschak, M; Uhlig, S | 1 |
| Fukutomi, H; Goto, K; Hassan, M; Kashimura, H; Matsumaru, K; Muto, H; Nakahara, A; Tanaka, N | 1 |
| Hoang, MV; Turner, AJ | 1 |
| Gao, XP; Olopade, CO; Pakhlevaniants, S; Rubinstein, I; Suzuki, H | 1 |
| Antonczak, S; Beaumont, A; Fournié-Zaluski, MC; Marie-Claire, C; O'Donohue, M; Roques, BP; Ruffet, E | 1 |
| Hintze, TH; Nasjletti, A; Xu, X; Zhang, X | 1 |
| Hoang, MV; Sansom, CE; Turner, AJ | 1 |
| Ehrenreich, H; Schilling, L; Schmiedek, P; Vatter, H | 1 |
| Blumberg, S; Davis, RG; Gao, XP; Rubinstein, I; Vishwanatha, JK | 1 |
| Fournie-Zaluski, MC; Marie-Claire, C; Ruffet, E; Tiraboschi, G | 1 |
| Bernstein, R; Hintze, TH; Nasjletti, A; Recchia, FA; Xu, X; Zhang, X | 1 |
| Hand, MF; Haynes, WG; Webb, DJ | 1 |
| Hashimoto, Y; Inui, K; Itoh, H; Nakao, K; Ozaki, J; Shimizu, H | 1 |
| Hintze, TH; Kaley, G; Kichuk, MR; Michler, R; Mital, S; Nasjletti, A; Oz, M; Zhang, X | 1 |
| Boileau, G; Carpentier, M; Crine, P; Desgroseillers, L; Ghaddar, G; Marcinkiewicz, M; Ruchon, AF; Seidah, NG | 1 |
| Mayoux, C; Pernet, I; Schmitt, D; Trompezinski, S; Viac, J | 1 |
| Inouye, K; Oneda, H | 1 |
| Harigaya, W; Iwata, H; Iwata, N; Iwatsubo, T; Kiryu-Seo, S; Kiyama, H; Maruyama, K; Saido, TC; Shirotani, K; Takaki, Y; Tomita, T; Tsubuki, S | 1 |
| Buschmann, MD; Chevrier, A; Crine, P; Hoemann, CD; Mort, JS | 1 |
| Ino, K; Itakura, A; Ito, M; Kajiyama, H; Kikkawa, F; Mizutani, S; Nomura, S; Tsujimoto, M; Watanabe, Y | 1 |
| Ansai, T; Awano, S; Carson, JA; Takehara, T; Turner, AJ; Yu, W | 1 |
| Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
| Berezin, AE | 1 |
| De Lima, TC; Duarte, FS; Testolin, R | 1 |
| D'Orléans-Juste, P; Fecteau, MH; Honoré, JC; Labonté, J; Plante, M; Rae, GA | 1 |
| Krassói, I; Márton, Z; Papp, JG; Pataricza, J; Varró, A | 1 |
| Audsley, N; Bland, ND; Isaac, RE; Shirras, AD; Thomas, JE; Turner, AJ | 1 |
| Ian Smith, A; Kuruppu, S; Reeve, S | 1 |
| Audsley, N; Isaac, RE; Johnson, EC; Shirras, AD | 1 |
| Kamata, K; Kobayashi, T; Matsumoto, T; Ozawa, Y; Taguchi, K | 1 |
| Barua, N; Gill, S; Kehoe, PG; Love, S; Miners, JS | 1 |
| Bhatia, M; Koh, YH; Moochhala, S | 1 |
| Grochulski, P; Labiuk, SL; Sygusch, J | 1 |
| Acharya, KR; Cozier, GE; Sharma, U; Sturrock, ED | 1 |
3 review(s) available for thiorphan and phosphoramidon
| Article | Year |
|---|---|
Release of tachykinins and its metabolism in the airway.
Topics: Animals; Anti-Bacterial Agents; Bronchi; Glycopeptides; Guinea Pigs; Humans; In Vitro Techniques; Leukotriene C4; Muscle Contraction; Muscle, Smooth; Ovalbumin; Tachykinins; Thiorphan | 1993 |
[The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
Topics: Glycopeptides; Heart Failure; Hemodynamics; Humans; Indans; Metalloproteases; Propionates; Protease Inhibitors; Pyridines; Thiazepines; Thiorphan | 2004 |
Aβ-degrading enzymes: potential for treatment of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Genetic Therapy; Glycopeptides; Humans; Insulysin; Mice; Mice, Transgenic; Microglia; Neprilysin; Protease Inhibitors; Stem Cell Transplantation; Thiorphan | 2011 |
2 trial(s) available for thiorphan and phosphoramidon
| Article | Year |
|---|---|
Endogenous endothelin generation maintains vascular tone in humans.
Topics: Adult; Blood Circulation; Endothelin-1; Endothelins; Glycopeptides; Humans; Male; Muscle Tonus; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Thiorphan; Vascular Resistance; Vasoconstriction; Vasodilation; Vasomotor System | 1995 |
Reduced endogenous endothelin-1-mediated vascular tone in chronic renal failure.
Topics: Adult; Endothelin Receptor Antagonists; Endothelin-1; Female; Forearm; Glycopeptides; Humans; Injections, Intra-Arterial; Kidney Failure, Chronic; Male; Middle Aged; Norepinephrine; Peptides, Cyclic; Protease Inhibitors; Receptor, Endothelin A; Regional Blood Flow; Thiorphan; Vasomotor System | 1999 |
93 other study(ies) available for thiorphan and phosphoramidon
| Article | Year |
|---|---|
Definition and display of steric, hydrophobic, and hydrogen-bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: validation of a high-resolution graphical tool for drug design.
Topics: Binding Sites; Drug Design; Hydrogen; Hydrogen Bonding; Ligands; Models, Molecular; Proteins; Surface Properties; Thermolysin; Trypsin; Trypsin Inhibitors | 1992 |
Enkephalinase inhibitors. 1. 2,4-Dibenzylglutaric acid derivatives.
Topics: Analgesics; Animals; Benzyl Compounds; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Crystallography; Glutarates; Male; Mice; Neprilysin; Structure-Activity Relationship | 1989 |
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Kidney; Neprilysin; Organophosphorus Compounds; Protease Inhibitors; Rats; Structure-Activity Relationship | 1985 |
Hydroxamic acids as potent inhibitors of endothelin-converting enzyme from human bronchiolar smooth muscle.
Topics: Aspartic Acid Endopeptidases; Bronchi; Cells, Cultured; Endothelin-Converting Enzymes; Humans; Hydroxamic Acids; Metalloendopeptidases; Muscle, Smooth | 1995 |
N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.
Topics: Animals; Antihypertensive Agents; Biological Availability; Biphenyl Compounds; Blood Pressure; Half-Life; Neprilysin; Organophosphonates; Phenylalanine; Phosphopeptides; Prodrugs; Rats; Structure-Activity Relationship | 1994 |
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Dipeptides; Magnetic Resonance Spectroscopy; Male; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfhydryl Compounds; Thiorphan; Tryptophan | 1995 |
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Humans; Male; Metalloendopeptidases; Organophosphonates; Protein Precursors; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tetrazoles | 2000 |
Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Fluorine; Humans; Neprilysin; Peptides; Peptidyl-Dipeptidase A; Protease Inhibitors; Sulfhydryl Compounds | 2009 |
Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay.
Topics: Animals; Aspartic Acid Endopeptidases; Endothelin-Converting Enzymes; Endothelins; Enzyme Assays; Enzyme Inhibitors; Fluorescent Dyes; Gene Expression Regulation, Enzymologic; Humans; Metalloendopeptidases; Mice; Organ Specificity; Peptide Library; Peptides; Substrate Specificity | 2010 |
Autoimmunoregulation: differential modulation of CD10/neutral endopeptidase 24.11 by tumor necrosis factor and neuropeptides.
Topics: Animals; Autoimmunity; Bivalvia; Dose-Response Relationship, Immunologic; Enkephalin, Methionine; Gene Expression Regulation; Glycopeptides; Granulocytes; Hemocytes; Humans; In Vitro Techniques; Melanocyte-Stimulating Hormones; Neprilysin; Neuropeptides; Substance P; Thiorphan; Tumor Necrosis Factor-alpha | 1992 |
Role of peptidases in bradykinin-induced increase in vascular permeability in vivo.
Topics: Animals; Bradykinin; Capillary Permeability; Captopril; Cheek; Cricetinae; Glycopeptides; Inflammation; Microcirculation; Neprilysin; Peptidyl-Dipeptidase A; Thiorphan | 1992 |
Jurkat T cells express a functional neutral endopeptidase activity (CALLA) involved in T cell activation.
Topics: Amino Acid Sequence; Base Sequence; Cell Line; Cell Membrane; Chromatography, High Pressure Liquid; Flow Cytometry; Glycopeptides; Humans; Interleukin-2; Kinetics; Lymphocyte Activation; Molecular Sequence Data; Neprilysin; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protease Inhibitors; Substrate Specificity; T-Lymphocytes; Thiorphan | 1992 |
Involvement of a phosphoramidon-sensitive endopeptidase in the processing of big endothelin-1 in the guinea-pig.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bronchi; Chymotrypsin; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Lung; Male; Neprilysin; Pepsin A; Protein Precursors; Sensitivity and Specificity; Thiorphan | 1992 |
Effect of cell density on endothelin release from endothelial cells and phosphoramidon dependent inhibition.
Topics: Animals; Cattle; Cell Count; Cell Survival; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Glycopeptides; Pepstatins; Thiorphan | 1992 |
Localization and characterization of neutral metalloendopeptidase (EC 3.4.24.11), the degradative enzyme for atrial natriuretic peptide, in rat kidney using a radioiodinated neutral metalloendopeptidase inhibitor.
Topics: Animals; Atrial Natriuretic Factor; Autoradiography; Binding, Competitive; Cell Membrane; Dipeptides; Drug Interactions; Glycopeptides; Iodine Radioisotopes; Kidney; Male; Neprilysin; Phenols; Phenylalanine; Rats; Rats, Inbred Strains; Thiorphan | 1992 |
Evidence for metalloprotease involvement in the in vivo effects of big endothelin 1.
Topics: Animals; Diuresis; Enalaprilat; Endothelin-1; Endothelins; Glomerular Filtration Rate; Glycopeptides; Hemodynamics; Infusions, Intravenous; Kidney; Male; Metalloendopeptidases; Natriuresis; Potassium; Protein Precursors; Rats; Rats, Inbred Strains; Renal Circulation; Thiorphan | 1991 |
Characterisation of neutral endopeptidase 3.4.24.11 (NEP) in the kidney: comparison between normotensive, genetically hypertensive and experimentally hypertensive rats.
Topics: Animals; Body Weight; Desoxycorticosterone; DNA; Glycopeptides; Hot Temperature; Hydrogen-Ion Concentration; Hypertension; Kidney Cortex; Neprilysin; Organ Size; Protein Denaturation; Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Salts; Thiorphan | 1991 |
Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat brainstem.
Topics: Animals; Brain Stem; Enkephalins; Enzyme Inhibitors; Glycopeptides; Histocytochemistry; Male; Neprilysin; Rats; Rats, Inbred Strains; Substance P; Thiorphan | 1990 |
Suppressive effects of enkephalins and REM sleep deprivation on seizures.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Enkephalins; Glycopeptides; Leucine; Male; Mice; Mice, Inbred Strains; Neprilysin; Nitrous Oxide; Rats; Rats, Inbred Strains; Sleep Deprivation; Sleep, REM; Substance Withdrawal Syndrome; Thiorphan | 1991 |
Epithelium modulates the potency of vasoactive intestinal peptide in the guinea pig.
Topics: Animals; Electric Stimulation; Epithelium; Female; Glycopeptides; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Thiorphan; Trachea; Vagus Nerve; Vasoactive Intestinal Peptide | 1991 |
Influence of thiorphan and phosphoramidon on the relaxant effect of vasoactive intestinal polypeptide and non-adrenergic non-cholinergic neurone stimulation in the rat gastric fundus.
Topics: Animals; Electric Stimulation; Female; Gallbladder; Gastric Fundus; Glycopeptides; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxation; Neprilysin; Neurons; Rats; Thermolysin; Thiorphan; Vasoactive Intestinal Peptide | 1991 |
Atrial natriuretic factor inhibits ciliary motility in cultured rabbit tracheal epithelium.
Topics: Animals; Atrial Natriuretic Factor; Captopril; Cells, Cultured; Cilia; Enzyme Inhibitors; Epithelium; Glycopeptides; Indomethacin; Kinetics; Leucine; Leupeptins; Male; Masoprocol; Methylene Blue; Movement; Piroxicam; Purinones; Rabbits; Thiorphan; Trachea | 1991 |
[Clinical significance and therapeutic application of atrial natriuretic peptides].
Topics: Animals; Atrial Natriuretic Factor; Glycopeptides; Heart Atria; Heart Failure; Hemodynamics; Humans; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Thiorphan | 1991 |
Inhibition of neutral endopeptidase potentiates bronchial contraction induced by immune response in guinea pigs in vitro.
Topics: Animals; Bronchi; Bronchoconstriction; Capsaicin; Glycopeptides; Guinea Pigs; Histamine; Immunization; In Vitro Techniques; Male; Neprilysin; Ovalbumin; Platelet Activating Factor; Serotonin; SRS-A; Thiorphan | 1991 |
Vascular A10 cell membranes contain an endothelin metabolizing neutral endopeptidase.
Topics: Alanine; Animals; Aorta; Cell Line; Cell Membrane; Endothelins; Glycopeptides; Kidney; Kinetics; Microvilli; Muscle, Smooth, Vascular; Neprilysin; Rats; Thiorphan | 1991 |
Effect of neutral endopeptidase inhibition of f-Met-Leu-Phe-induced bronchoconstriction in the rabbit.
Topics: Airway Resistance; Animals; Atropine; Bronchi; Glycopeptides; Morphine; N-Formylmethionine Leucyl-Phenylalanine; Neprilysin; Rabbits; Thiorphan | 1991 |
Tissue distribution of neutral endopeptidase 24.11 ('enkephalinase') activity in guinea pig trachea.
Topics: Animals; Bacitracin; Captopril; Enalapril; Epithelium; Female; Glycopeptides; Guinea Pigs; Immunohistochemistry; Neprilysin; Thiorphan; Trachea | 1991 |
Effects of epithelium removal on relaxation of airway smooth muscle induced by vasoactive intestinal peptide and electrical field stimulation.
Topics: Animals; Atropine; Captopril; Electric Stimulation; Endopeptidases; Epithelium; Glycopeptides; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Propranolol; Protease Inhibitors; Thiorphan; Trachea; Vasoactive Intestinal Peptide | 1990 |
Enkephalinase inhibitors potentiate substance P-induced secretion of 35SO4-macromolecules from ferret trachea.
Topics: Animals; Drug Synergism; Endopeptidases; Enkephalin, Methionine; Ferrets; Glycopeptides; In Vitro Techniques; Male; Molecular Weight; Mucus; Neprilysin; Protease Inhibitors; Rabbits; Substance P; Sulfates; Thiorphan; Tiopronin; Trachea | 1987 |
Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Complement C3; Complement C3a; Complement C5; Complement C5a; Drug Interactions; Endopeptidases; Glycopeptides; Guinea Pigs; Lung; Muscle Contraction; N-Formylmethionine Leucyl-Phenylalanine; Peptidyl-Dipeptidase A; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Thiorphan; Tiopronin; Trachea | 1987 |
Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs.
Topics: Animals; Capsaicin; Cough; Drug Synergism; Glycopeptides; Guinea Pigs; Male; Neprilysin; Substance P; Thiorphan | 1988 |
Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle.
Topics: Animals; Drug Synergism; Duodenum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ferrets; Glycopeptides; Ileum; Intestines; Male; Muscle Contraction; Protease Inhibitors; Rats; Substance P; Thiorphan | 1989 |
Inhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced noncholinergic contraction in guinea pig bronchi.
Topics: Animals; Bronchi; Capsaicin; Electric Stimulation; Glycopeptides; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Neprilysin; Substance P; Thiorphan | 1989 |
Degradation of atrial natriuretic peptide: pharmacologic effects of protease EC 24.11 inhibition.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Glycopeptides; Heart Rate; In Vitro Techniques; Kidney; Male; Protease Inhibitors; Rats; Rats, Inbred SHR; Sodium; Thiorphan; Time Factors | 1989 |
Central modulatory effects of tachykinin peptides on airway tone.
Topics: Airway Resistance; Animals; Cats; Female; Glycopeptides; Male; Medulla Oblongata; Neprilysin; Neurokinin A; Phrenic Nerve; Substance P; Thiorphan; Trachea | 1989 |
Characterisation of enkephalinase (EC 3.4.24.11) activity on various leukemic cells expressing the common acute lymphocytic leukemia antigen (CALLA).
Topics: Antigens, Differentiation; Antigens, Neoplasm; Bone Marrow; Cell Division; Cell Line; Cell Membrane; Dipeptides; Glycopeptides; Humans; In Vitro Techniques; Neprilysin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thiorphan; Tumor Cells, Cultured | 1989 |
Enkephalinase inhibition increases plasma atrial natriuretic peptide levels, glomerular filtration rate, and urinary sodium excretion in rats with reduced renal mass.
Topics: Animals; Anti-Bacterial Agents; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Glomerular Filtration Rate; Glycopeptides; Kidney; Male; Nephrectomy; Neprilysin; Rats; Rats, Inbred Strains; Reference Values; Sodium; Thiorphan | 1989 |
pH- and time-dependent inhibition of rat kidney neutral endoprotease 24.11 by thiorphan and phosphoramidon.
Topics: Animals; Glycopeptides; Hydrogen-Ion Concentration; Kidney; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Time Factors | 1989 |
The inactivation of [Met5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens.
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Captopril; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Neprilysin; Peptidyl-Dipeptidase A; Phenylalanine; Thiorphan; Tiopronin; Vas Deferens | 1986 |
Enkephalinase inhibitors attenuate naloxone-precipitated withdrawal syndrome.
Topics: Amino Acids, Sulfur; Animals; Cerebral Ventricles; Cerebrospinal Fluid; Dipeptides; Glycopeptides; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1986 |
Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Ferrets; Glycopeptides; Kinins; Male; Metalloendopeptidases; Muscle Contraction; Neprilysin; Thiorphan; Tiopronin; Trachea | 1988 |
Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalins; Glycopeptides; Hydrolysis; Kidney; Neprilysin; Organophosphorus Compounds; Protease Inhibitors; Swine; Synaptic Membranes; Thermolysin; Thiorphan; Tiopronin | 1982 |
Prolonged treatment by phosphoramidon modulates the number of endothelin receptors in cultured Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Endothelins; Fibroblasts; Glycopeptides; Iodine Radioisotopes; Kinetics; Mice; Protease Inhibitors; Receptors, Endothelin; Thiorphan | 1993 |
Urinary neutral endopeptidase 24.11 activity: modulation by chronic salt loading.
Topics: Animals; Diet; Glycopeptides; Kidney; Male; Neprilysin; Rats; Rats, Wistar; Sodium; Sodium Chloride; Thiorphan | 1995 |
[Elastase-type endopeptidase of fibroblasts. Effect of metalloprotease inhibitors].
Topics: Adult; Female; Fibroblasts; Glycopeptides; Humans; Neprilysin; Pancreatic Elastase; Protease Inhibitors; Skin; Thiorphan | 1995 |
Effects of metalloprotease inhibitors on smooth muscle endothelin-converting enzyme activity.
Topics: Animals; Aspartic Acid Endopeptidases; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Activation; Glycopeptides; Metalloendopeptidases; Methionine; Muscle, Smooth, Vascular; Propionates; Protein Precursors; Structure-Activity Relationship; Swine; Thiorphan | 1995 |
Selective proteolitic activation and degradation of ETs and big ETs in parenchymal strips of the guinea-pig lung.
Topics: Animals; Captopril; Endopeptidases; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Humans; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Protein Precursors; Structure-Activity Relationship; Swine; Thiorphan | 1995 |
Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Endothelin-3; Endothelins; Ganglionic Blockers; Glycopeptides; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; Thiorphan; Vas Deferens | 1993 |
Effects of metalloprotease inhibitors on the conversion of proendothelin-1 to endothelin-1.
Topics: Animals; Aspartic Acid Endopeptidases; Benzazepines; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Endothelium, Vascular; Glycopeptides; In Vitro Techniques; Male; Metalloendopeptidases; Methionine; Muscle Contraction; Muscle, Smooth, Vascular; Neprilysin; Propionates; Protein Precursors; Rats; Rats, Sprague-Dawley; Swine; Thiorphan | 1993 |
Effect of some peptidase inhibitors on exogenous and endogenous opioid actions in guinea-pig ileum.
Topics: Aminopeptidases; Animals; Bacitracin; Captopril; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; Leucine; Male; Morphine; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Thiorphan | 1994 |
Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane.
Topics: Animals; Aspartic Acid Endopeptidases; Cell Membrane; Chromatography, Affinity; Endothelin-Converting Enzymes; Endothelins; Glycopeptides; Humans; Hydrogen-Ion Concentration; Lectins; Lung; Metalloendopeptidases; Substrate Specificity; Swine; Thiorphan | 1993 |
Characterization of neutral endopeptidase 24.11 in dog glomeruli.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Blotting, Western; Dogs; Enkephalin, Leucine-2-Alanine; gamma-Aminobutyric Acid; Glycopeptides; Glycosylation; Immunoblotting; Iodobenzenes; Kidney Glomerulus; Kidney Tubules, Proximal; Microvilli; Neprilysin; Octoxynol; Polyethylene Glycols; Thiorphan | 1993 |
Characterization of the endothelin-converting enzyme in guinea pig upper bronchus.
Topics: Animals; Aspartic Acid Endopeptidases; Bronchi; Dose-Response Relationship, Drug; Endothelin-Converting Enzymes; Endothelins; Glycopeptides; Guinea Pigs; Metalloendopeptidases; Thiorphan | 1995 |
Guinea pig Clara cells secrete endothelin 1 through a phosphoramidon-sensitive pathway.
Topics: Animals; Antibodies, Monoclonal; Aspartic Acid Endopeptidases; Cells, Cultured; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Fluorescent Antibody Technique; Glycopeptides; Guinea Pigs; Lung; Metalloendopeptidases; Specific Pathogen-Free Organisms; Thiorphan | 1996 |
Metallopeptidase inhibitors induce an up-regulation of endothelin-converting enzyme levels and its redistribution from the plasma membrane to an intracellular compartment.
Topics: Animals; Aspartic Acid Endopeptidases; Base Sequence; Cell Compartmentation; Cell Membrane; Cells, Cultured; Endothelin-Converting Enzymes; Fluorescent Antibody Technique; Glycopeptides; Immunoblotting; Immunomagnetic Separation; Metalloendopeptidases; Molecular Sequence Data; Protease Inhibitors; Swine; Thiorphan; Up-Regulation | 1996 |
Neutral endopeptidase modulates VIP-induced vasodilation in hamster cheek pouch vessels in situ.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Captopril; Cheek; Cricetinae; Drug Combinations; Glycopeptides; Male; Mesocricetus; Neprilysin; Protease Inhibitors; Thiorphan; Vasoactive Intestinal Peptide; Vasodilation | 1996 |
In vitro metabolism of an insect neuropeptide by neural membrane preparations from Lymantria dispar.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Anti-Bacterial Agents; Edetic Acid; Endopeptidases; Ganglia, Invertebrate; Glycopeptides; In Vitro Techniques; Insect Hormones; Lepidoptera; Leucine; Molecular Sequence Data; Peptides; Protease Inhibitors; Thiorphan | 1996 |
Role of the neutral endopeptidase 24.11 in the conversion of big endothelins in guinea-pig lung parenchyma.
Topics: Alanine; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Neprilysin; Protease Inhibitors; Protein Precursors; Thiorphan | 1996 |
Characterization of endothelin converting enzyme from intact cells of a permanent human endothelial cell line, EA.hy926.
Topics: Aspartic Acid Endopeptidases; Cells, Cultured; Endometrium; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Female; Glycopeptides; Humans; Metalloendopeptidases; Protein Precursors; Radioimmunoassay; Thiorphan | 1996 |
Neutral endopeptidase inhibition, a new approach in the exploration of diabetic vasculopathy in rats.
Topics: Alanine; Animals; Blood Pressure; Capillary Permeability; Captopril; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Female; Glycopeptides; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Streptozocin; Thiorphan | 1995 |
Sch 37224, an experimental antiallergy compound, inhibits the neuropeptide component of hyperventilation- and nicotine-induced bronchoconstriction in guinea pigs.
Topics: Animals; Bronchoconstriction; Bronchoconstrictor Agents; Glycopeptides; Guinea Pigs; Histamine H1 Antagonists; Hyperventilation; Male; Metalloendopeptidases; Naphthyridines; Neurokinin A; Nicotine; Protease Inhibitors; Thiorphan | 1997 |
Phosphoramidon and thiorphan suppress the generation of endothelin (ET) from exogenous big-endothelin by guinea pig Clara cells.
Topics: Animals; Bronchi; Cells, Cultured; Endothelin-1; Endothelins; Epithelial Cells; Epithelium; Glycopeptides; Guinea Pigs; Metalloendopeptidases; Protease Inhibitors; Protein Precursors; Radioimmunoassay; Thiorphan | 1997 |
Rat big endothelin-1-induced bronchoconstriction and vasoconstriction in the isolated perfused rat lung: role of endothelin converting enzyme and neutral endopeptidase 24.11.
Topics: Airway Resistance; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Bronchoconstriction; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Female; Glycopeptides; Lung; Metalloendopeptidases; Neprilysin; Organophosphonates; Perfusion; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Tetrazoles; Thiorphan; Vascular Resistance; Vasoconstriction | 1997 |
Phosphoramidon, an endothelin converting enzyme inhibitor attenuates local gastric ischemia-reperfusion injury in rats.
Topics: Animals; Aspartic Acid Endopeptidases; Endothelin-Converting Enzymes; Enzyme Inhibitors; Gastric Mucosa; Glycopeptides; Ischemia; Male; Metalloendopeptidases; Rats; Rats, Wistar; Reperfusion Injury; Thiorphan | 1997 |
Novel activity of endothelin-converting enzyme: hydrolysis of bradykinin.
Topics: Animals; Aspartic Acid Endopeptidases; Blotting, Western; Bradykinin; Chelating Agents; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Edetic Acid; Endopeptidases; Endothelin-Converting Enzymes; Enzyme Inhibitors; Glycopeptides; Hydrolysis; Kinetics; Metalloendopeptidases; Peptide Fragments; Rats; Substrate Specificity; Thiorphan | 1997 |
Angiotensin-converting enzyme and neutral endopeptidase modulate smokeless tobacco-induced increase in macromolecular efflux from the oral mucosa in vivo.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Capillary Permeability; Captopril; Cricetinae; Dextrans; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Glycopeptides; Lisinopril; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Neprilysin; Peptidyl-Dipeptidase A; Plants, Toxic; Protease Inhibitors; Thiorphan; Tobacco, Smokeless | 1997 |
Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding.
Topics: Amino Acid Sequence; Arginine; Bacillus subtilis; Binding, Competitive; DNA, Complementary; Glycopeptides; Hydrolysis; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Neprilysin; Protease Inhibitors; Recombinant Proteins; Substrate Specificity; Thermolysin; Thiorphan | 1997 |
Neutral endopeptidase and angiotensin-converting enzyme inhibitors increase nitric oxide production in isolated canine coronary microvessels by a kinin-dependent mechanism.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin Receptor Antagonists; Coronary Vessels; Coumarins; Dogs; Drug Interactions; Glycopeptides; In Vitro Techniques; Isocoumarins; Neprilysin; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Protease Inhibitors; Ramipril; Serine Proteinase Inhibitors; Thiorphan | 1998 |
Mutagenesis of Glu403 to Cys in rabbit neutral endopeptidase-24.11 (neprilysin) creates a disulphide-linked homodimer: analogy with endothelin-converting enzyme.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid Endopeptidases; COS Cells; Cystine; Dimerization; Disulfides; Endothelin-Converting Enzymes; Enkephalin, Leucine-2-Alanine; Glutamic Acid; Glycopeptides; Humans; Immunoblotting; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Mutagenesis, Site-Directed; Neprilysin; Oligopeptides; Protease Inhibitors; Protein Conformation; Rabbits; Rats; Thiorphan | 1997 |
Evidence for functional endothelin-converting enzyme activity in isolated rat basilar artery: effect of inhibitors.
Topics: Animals; Aspartic Acid Endopeptidases; Basilar Artery; Endothelin-Converting Enzymes; Glycopeptides; In Vitro Techniques; Male; Metalloendopeptidases; Muscle Contraction; Muscle, Smooth, Vascular; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Thiorphan | 1998 |
Increased tissue neutral endopeptidase 24.11 activity in spontaneously hypertensive hamsters.
Topics: Animals; Anions; Chlorides; Cricetinae; Glycopeptides; Hypertension; Kidney; Neprilysin; Osmolar Concentration; Protease Inhibitors; Thiorphan | 1998 |
Differences in transition state stabilization between thermolysin (EC 3.4.24.27) and neprilysin (EC 3.4.24.11).
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus subtilis; Catalytic Domain; Enzyme Stability; Glycopeptides; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Neprilysin; Protease Inhibitors; Protein Conformation; Recombinant Proteins; Thermolysin; Thiorphan; Tyrosine | 1998 |
Kinin-mediated coronary nitric oxide production contributes to the therapeutic action of angiotensin-converting enzyme and neutral endopeptidase inhibitors and amlodipine in the treatment in heart failure.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin Receptor Antagonists; Coronary Vessels; Cysteine Proteinase Inhibitors; Dogs; Enalaprilat; Glycopeptides; Heart Failure; Kininogens; Kinins; Nitric Oxide; Protease Inhibitors; Ramipril; Receptor, Bradykinin B2; Thiorphan; Vasodilator Agents | 1999 |
Enzymatic inactivation of major circulating forms of atrial and brain natriuretic peptides.
Topics: Animals; Atrial Natriuretic Factor; Cell Culture Techniques; Cyclic GMP; Glycopeptides; Humans; LLC-PK1 Cells; Male; Natriuresis; Neprilysin; Nitrobenzenes; Protease Inhibitors; Rats; Rats, Wistar; Swine; Thiorphan | 1999 |
Amlodipine promotes kinin-mediated nitric oxide production in coronary microvessels of failing human hearts.
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Bradykinin Receptor Antagonists; Calcium Channel Blockers; Cardiac Output, Low; Coronary Vessels; Dose-Response Relationship, Drug; Glycopeptides; Humans; Metalloendopeptidases; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrites; Quinine; Ramipril; Serine Proteinase Inhibitors; Thiorphan | 1999 |
Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family.
Topics: Amino Acid Sequence; Animals; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glycopeptides; Glycosylation; Humans; In Situ Hybridization; Inhibitory Concentration 50; Male; Metalloendopeptidases; Mice; Molecular Sequence Data; Neprilysin; Organ Specificity; Protein Processing, Post-Translational; RNA, Messenger; Sequence Alignment; Solubility; Subtilisin; Testis; Thiorphan; Transfection; Zinc | 2000 |
Modulation of endothelin-1 in normal human keratinocytes by UVA1/B radiations, prostaglandin E2 and peptidase inhibitors.
Topics: Cells, Cultured; Dinoprostone; Endothelin-1; Endothelins; Gene Expression Regulation; Glycopeptides; Humans; Infant, Newborn; Keratinocytes; Male; Polymerase Chain Reaction; Protease Inhibitors; Protein Precursors; Skin; Thiorphan; Transcription, Genetic; Ultraviolet Rays | 2000 |
Interactions of human matrix metalloproteinase 7 (matrilysin) with the inhibitors thiorphan and R-94138.
Topics: Acetamides; Drug Design; Enzyme Stability; Glycopeptides; Humans; Hydrogen-Ion Concentration; Hydroxamic Acids; Kinetics; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Protease Inhibitors; Protein Binding; Static Electricity; Structure-Activity Relationship; Temperature; Thermodynamics; Thiorphan | 2001 |
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Base Sequence; Chromosome Mapping; Cloning, Molecular; Endopeptidases; Enzyme Inhibitors; Glycopeptides; Humans; Isoenzymes; Kinetics; Molecular Sequence Data; Neprilysin; Neurons; Peptide Fragments; Recombinant Proteins; Substrate Specificity; Thiorphan; X Chromosome | 2001 |
Soluble recombinant neprilysin induces aggrecanase-mediated cleavage of aggrecan in cartilage explant cultures.
Topics: Aggrecans; Animals; Blotting, Western; Cartilage; Cattle; Chondrocytes; Detergents; Endopeptidases; Extracellular Matrix Proteins; Glycopeptides; Glycosaminoglycans; Immunohistochemistry; Lectins, C-Type; Neprilysin; Octoxynol; Organ Culture Techniques; Peptides; Polyethylene Glycols; Precipitin Tests; Protease Inhibitors; Proteoglycans; Recombinant Proteins; Thiorphan; Time Factors | 2001 |
Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.
Topics: Adult; Antibodies, Blocking; Chorionic Villi; Chromatography, High Pressure Liquid; Edetic Acid; Female; Glycopeptides; Gonadotropin-Releasing Hormone; Humans; Intracellular Membranes; Labor, Obstetric; Leucine; Leucyl Aminopeptidase; Neprilysin; Organ Culture Techniques; Phenanthrolines; Pregnancy; Pregnancy Trimester, First; Protease Inhibitors; Thiorphan | 2002 |
Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1.
Topics: Angiotensin I; Angiotensin II; Aspartic Acid Endopeptidases; Bacterial Proteins; Bradykinin; Chromatography, High Pressure Liquid; Endothelin-Converting Enzymes; Enzyme Activation; Enzyme Inhibitors; Glycopeptides; Humans; Hydrolysis; Inhibitory Concentration 50; Metalloendopeptidases; Neurotensin; Porphyromonas gingivalis; Substance P; Thiorphan | 2002 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Glycopeptides; Indoles; Injections, Intraventricular; Male; Maze Learning; Microinjections; Motor Activity; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Receptors, Neurokinin-2; Substance P; Thiorphan; Time Factors | 2004 |
Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Female; Glycopeptides; Heart Ventricles; Injections; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Peptide Fragments; Protease Inhibitors; Rabbits; Receptors, Endothelin; Thiorphan | 2005 |
NEP inhibitors enhance C-type natriuretic peptide-induced relaxation in porcine isolated coronary artery.
Topics: Animals; Coronary Vessels; Glycopeptides; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Neprilysin; Oligopeptides; Protease Inhibitors; Swine; Thiorphan | 2005 |
Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster.
Topics: Animals; Blotting, Western; Drosophila melanogaster; Embryo, Nonmammalian; Endopeptidases; Enzyme Activation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glycopeptides; Hydrogen-Ion Concentration; Immunoprecipitation; In Situ Hybridization; Neprilysin; Recombinant Proteins; Thiorphan | 2007 |
Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.
Topics: Amino Acid Sequence; Aspartic Acid Endopeptidases; Catalysis; Cell Line; Chromatography, Liquid; Dipeptides; Endothelial Cells; Endothelin-Converting Enzymes; Endothelins; Enzyme Activation; Glycopeptides; Humans; Metalloendopeptidases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Tandem Mass Spectrometry; Thiorphan; Umbilical Veins | 2007 |
Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila.
Topics: Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Drosophila melanogaster; Drosophila Proteins; Glycopeptides; Head; Humans; Hydrolysis; Membranes; Neprilysin; Neuropeptides; Peptides; Protein Processing, Post-Translational; Receptors, G-Protein-Coupled; Recombinant Proteins; Thiorphan | 2007 |
Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Glucose; Body Weight; Coronary Vessels; Diabetes Mellitus, Experimental; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; Glycopeptides; Heart; Lipids; Lysine; Male; Metalloendopeptidases; Myocardium; Oligopeptides; Organ Size; Organophosphonates; Peptides, Cyclic; Perfusion; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Thiorphan; Vasoconstriction | 2010 |
The role of neutral endopeptidase in caerulein-induced acute pancreatitis.
Topics: Acinar Cells; Animals; Ceruletide; Glycopeptides; Lung; Male; Mice; Mice, Inbred BALB C; Neprilysin; Pancreatitis, Acute Necrotizing; Random Allocation; Recombinant Proteins; RNA, Messenger; Severity of Illness Index; Thiorphan | 2011 |
Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan.
Topics: Amino Acid Sequence; Animals; Crystallography, X-Ray; Glycopeptides; Models, Molecular; Neprilysin; Protease Inhibitors; Protein Conformation; Rabbits; Substrate Specificity; Thiorphan | 2019 |
Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Crystallography, X-Ray; Drug Design; Mesylates; Neprilysin; Peptidyl-Dipeptidase A; Protein Binding; Protein Structure, Secondary; Pyridines; Thiazepines; Tyrosine | 2020 |