thiorphan has been researched along with naloxone in 58 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (56.90) | 18.7374 |
| 1990's | 23 (39.66) | 18.2507 |
| 2000's | 2 (3.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bokszanska, A; Brinkman, EC; Cappendijk, SL; Dzoljic, M; Dzoljic, MR; Kaplan, CD; Korenhof, AM; Rupreht, J; Zijlstra, FJ | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Froehlich, JC; Harts, J; Li, TK; Lumeng, L; Zweifel, M | 1 |
| Bachoo, M; Polosa, C; Zhang, C | 1 |
| Azerad, J; Desmonts, JM; Limoge, A; Mantz, J | 1 |
| Horii, S; Kanemura, T; Takizawa, T; Tamaoki, J; Yamawaki, I | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Herz, A; Parsons, CG | 1 |
| Kehl, LJ | 1 |
| Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A | 1 |
| Gonzalez, JP; Patel, A; Sewell, RD; Smith, HJ; Williams, PS; Yu, Z | 1 |
| Caline, H; Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Jivegård, L; Moreau, J; Pollard, H; Schwartz, JC; Svanvik, J; Thune, A | 1 |
| Callebert, J; Daugé, V; Feger, J; Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Villette, JM | 1 |
| Dzoljic, MR; Haffmans, J; van Amsterdam, JC; Walsum, MV | 1 |
| Buéno, L; Fioramonti, J | 1 |
| Costentin, J; Giros, B; Michael-Titus, A; Preterre, P | 1 |
| Dzoljic, MR | 1 |
| Livingston, SJ; Rooney, KF; Sewell, RD; Smith, HJ | 1 |
| Hill, RG; Hughes, J; Pittaway, KM | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T | 1 |
| Fukaya, H; Furukawa, H; Hiramatsu, M; Kameyama, T; Nabeshima, T | 1 |
| Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H | 1 |
| Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF | 1 |
| Costentin, J; Lecomte, JM; Marçais-Collado, H; Schwartz, JC; Uchida, G | 1 |
| Han, JS; Jin, WQ; Zhou, ZF | 1 |
| Chaillet, P; Costentin, J; Leboyer, M; Lecomte, JM; Llorens-Cortes, C; Marcais-Collado, H; Schwartz, JC; Vlaiculescu, A | 1 |
| Coquerel, A; Costentin, J; Dubuc, I; Kitabgi, P; Menard, JF | 1 |
| Dzoljic, MR; Haffmans, J | 1 |
| Anadón, A; Martinez-Larrañaga, MR | 1 |
| Beckman, AL; Sartin, NF; Stanton, TL | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Zajac, JM | 1 |
| Bean, AJ; Vaught, JL | 1 |
| Guilbaud, G; Kayser, V | 1 |
| Chaillet, P; Costentin, J; Lecomte, JM; Marçais, H; Natan, LB; Uchida, G | 1 |
| Giovino, AA; Glimcher, PW; Hoebel, BG; Margolin, DH | 1 |
| de Groat, WC; Hisamitsu, T | 1 |
| Chipkin, RE; O'Connor, P | 1 |
| Llorens-Cortes, C; Schwartz, JC | 1 |
| Barnett, A; Berger, J; Billard, W; Chipkin, RE; Iorio, LC | 1 |
| Barnett, A; Chipkin, RE; Iorio, LC; Latranyi, MZ | 1 |
| Adjroud, O | 1 |
| Ogg, BG; Sangha, S; Stevens, CW | 1 |
| Berens, CF; Dumont, P; Lambert, DM; Mergen, F; Poupaert, JH | 1 |
| Fuentes, JA; Iglesias, T; Otero, MJ | 1 |
| Dumont, P; Lambert, DM; Mergen, F; Poupaert, JH | 1 |
| Benouali, S; Berard, H; Roche, M | 1 |
| Bell, SC; Berend, N; Finnimore, AJ; Matheson, MJ; Rynell, AC | 1 |
| Belowski, D; Herman, ZS; Kowalski, J; Madej, A | 1 |
| Matsuda, T; Mori, M; Tsushima, H | 1 |
| Parenti, C; Scoto, GM | 1 |
| Gray, AM; Sewell, RD; Spencer, PS | 1 |
| Brown, CH; Doi, N; Dutia, MB; Leng, G; Russell, JA | 1 |
| Bourin, M; Colombel, MC; Malinge, M; Vasar, E | 1 |
| Baumer, P; Berard, H; Bueno, L; Lecomte, JM; Primi, MP | 1 |
| Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB | 1 |
| Holtzman, SG; Justice, JB; Schad, CA | 1 |
1 review(s) available for thiorphan and naloxone
| Article | Year |
|---|---|
Enkephalins, other endogenous opioids and colonic motility in dog and man.
Topics: Animals; Central Nervous System; Colon; Dogs; Endorphins; Enkephalins; Gastrointestinal Motility; Humans; In Vitro Techniques; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Species Specificity; Thiorphan; Tiopronin | 1987 |
57 other study(ies) available for thiorphan and naloxone
| Article | Year |
|---|---|
The effects of orally active enkephalinase inhibitors on morphine withdrawal syndrome.
Topics: Administration, Oral; Analgesics; Animals; Dioxolanes; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice; Morphine; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Wistar; Stereotyped Behavior; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Importance of delta opioid receptors in maintaining high alcohol drinking.
Topics: Alcohol Drinking; Animals; Drinking Behavior; Enkephalin, Leucine; Male; Naloxone; Narcotic Antagonists; Neprilysin; Phenylpropionates; Rats; Receptors, Opioid; Receptors, Opioid, delta; Thiorphan | 1991 |
Naloxone-sensitive inhibition of nicotinic transmission in the superior cervical ganglion of the cat.
Topics: Action Potentials; Animals; Axons; Captopril; Cats; Electric Stimulation; Female; Ganglia, Sympathetic; Hexamethonium; Hexamethonium Compounds; Leucine; Male; Naloxone; Protease Inhibitors; Receptors, Nicotinic; Synapses; Synaptic Transmission; Thiorphan | 1991 |
Transcranial electrical stimulation with Limoge's currents decreases halothane requirements in rats. Evidence for the involvement of endogenous opioids.
Topics: Anesthesia, Inhalation; Animals; Electric Stimulation; Enkephalins; Halothane; Male; Methysergide; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Ritanserin; Thiorphan; Yohimbine | 1992 |
Effects of beta-endorphin and dynorphin A on cholinergic neurotransmission in canine airway smooth muscle.
Topics: Animals; beta-Endorphin; Bronchi; Captopril; Dogs; Dynorphins; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Protease Inhibitors; Synaptic Transmission; Thiorphan | 1990 |
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan | 1990 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming; Thiorphan | 1990 |
Analgesia after inhibition of enkephalin degradation.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Neprilysin; Protease Inhibitors; Spinal Cord; Substance P; Thiorphan; Tiopronin | 1986 |
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra.
Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin | 1987 |
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Neprilysin; Pain; Proline; Protease Inhibitors; Thiohydantoins; Thiorphan | 1989 |
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Pain; Protease Inhibitors; Reference Values; Species Specificity; Thiorphan | 1989 |
Naloxone-reversible inhibition of gall-bladder mucosal fluid secretion in experimental cholecystitis in the cat by acetorphan, an enkephalinase inhibitor.
Topics: Animals; Bile; Cats; Cholecystitis; Gallbladder; Mucous Membrane; Naloxone; Neprilysin; Thiorphan | 1989 |
Comparison of selective and complete inhibitors of enkephalin-degrading enzymes on morphine withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Hydroxamic Acids; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1989 |
Phelorphan, an inhibitor of enzymes involved in the biodegradation of enkephalins, affected the withdrawal symptoms in chronic morphine-dependent rats.
Topics: Aminopeptidases; Animals; Brain; CD13 Antigens; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Male; Morphine Dependence; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1987 |
Role of endogenous enkephalins in locomotion evidenced by acetorphan, an "enkephalinase" inhibitor.
Topics: Amino Acids, Sulfur; Animals; Dose-Response Relationship, Drug; Enkephalins; Hydroxydopamines; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thiorphan; Tiopronin | 1987 |
Enkephalinase inhibitors attenuate naloxone-precipitated withdrawal syndrome.
Topics: Amino Acids, Sulfur; Animals; Cerebral Ventricles; Cerebrospinal Fluid; Dipeptides; Glycopeptides; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1986 |
Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Body Temperature; Body Weight; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1988 |
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors.
Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time; Sincalide; Tetragastrin; Thiorphan; Tiopronin | 1987 |
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility).
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin | 1988 |
Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin.
Topics: Amino Acids, Sulfur; Animals; Drug Synergism; Leucine; Male; Naloxone; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Thiorphan; Time Factors; Tiopronin | 1986 |
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain.
Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Time Factors; Tiopronin | 1986 |
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1987 |
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors.
Topics: Amino Acids, Sulfur; Animals; Castor Oil; Diarrhea; Drug Interactions; Gastrointestinal Transit; Loperamide; Male; Metalloendopeptidases; Mice; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1987 |
Electroacupuncture and morphine analgesia potentiated by bestatin and thiorphan administered to the nucleus accumbens of the rabbit.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Immune Sera; Leucine; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Rabbits; Septal Nuclei; Thiorphan; Time Factors; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1986 |
Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Antidiarrheals; Biogenic Amines; Brain Chemistry; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Injections; Kinetics; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1986 |
Naloxone-insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan.
Topics: Amino Acids, Sulfur; Animals; Body Temperature; Captopril; Drug Synergism; Endopeptidases; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Neprilysin; Neurotensin; Thiorphan; Tiopronin | 1986 |
Inhibition of enkephalinase activity attenuates naloxone-precipitated withdrawal symptoms.
Topics: Amino Acids, Sulfur; Animals; Behavior, Animal; Endopeptidases; Injections; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1987 |
An inhibitory action of tetracyclines on guinea-pig myenteric plexus.
Topics: Animals; Captopril; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Leucine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Protease Inhibitors; Tetracyclines; Thiorphan; Tiopronin | 1987 |
Changes in body temperature and metabolic rate following microinjection of Met-enkephalinamide in the preoptic/anterior hypothalamus of rats.
Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Enkephalin, Methionine; Male; Metabolic Clearance Rate; Microinjections; Naloxone; Preoptic Area; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1985 |
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia.
Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1984 |
Physical dependence produced by chronic intracerebroventricular infusion of [D-Arg]kyotorphin or thiorphan to rats.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Cerebral Ventricles; Endorphins; Humans; Male; Morphine; Naloxone; Neprilysin; Opioid-Related Disorders; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1984 |
The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Arthritis; Arthritis, Experimental; Male; Morphine; Naloxone; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Thiorphan; Tiopronin; Vocalization, Animal | 1983 |
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test.
Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
Endogenous opiate reward induced by an enkephalinase inhibitor, thiorphan, injected into the ventral midbrain.
Topics: Amino Acids, Sulfur; Animals; Endorphins; Enkephalin, Methionine; Female; Mesencephalon; Naloxone; Rats; Rats, Inbred Strains; Reward; Tegmentum Mesencephali; Thiorphan; Tiopronin | 1984 |
The inhibitory effect of opioid peptides and morphine applied intrathecally and intracerebroventricularly on the micturition reflex in the cat.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Morphine; Naloxone; Oligopeptides; Reflex; Thiorphan; Tiopronin; Urination | 1984 |
Comparisons between warm and cold water swim stress in mice.
Topics: Analgesia; Animals; Cold Temperature; Hot Temperature; Male; Mice; Naloxone; Protease Inhibitors; Stress, Physiological; Swimming; Thiorphan; Time Factors; Tiopronin | 1984 |
Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin.
Topics: alpha-Methyltyrosine; Amino Acids, Sulfur; Aminopeptidases; Animals; Biogenic Amines; Brain; Enkephalins; Leucine; Male; Methyltyrosines; Mice; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
In vitro and in vivo effects of thiorphan: an inhibitor of enkephalinase A.
Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesics; Animals; Captopril; Drug Synergism; Enkephalins; In Vitro Techniques; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin | 1982 |
Potentiation of [D-ala2]enkephalinamide analgesia in rats by thiorphan.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Drug Synergism; Enkephalin, Methionine; Male; Naloxone; Neprilysin; Nociceptors; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Time Factors; Tiopronin | 1982 |
Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue, [D-Ala2-Met5]-enkephalinamide, on uterine motility in periparturient rats in vivo and in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Naloxone; Narcotic Antagonists; Neprilysin; Neurotransmitter Agents; Pregnancy; Protease Inhibitors; Rats; Rats, Wistar; Stimulation, Chemical; Thiorphan; Uterine Contraction | 1995 |
Analgesia produced by immobilization stress and an enkephalinase inhibitor in amphibians.
Topics: Acetates; Acetic Acid; Analgesia; Animals; Immobilization; Injections, Spinal; Leucine; Naloxone; Neprilysin; Pain Measurement; Protease Inhibitors; Rana pipiens; Stress, Psychological; Thiorphan | 1995 |
Synthesis and pharmacological properties of 2-[S-acetylthiorphan]-1,3- diacylaminopropan-2-ol derivatives as chimeric lipid drug carriers containing an enkephalinase inhibitor.
Topics: Administration, Oral; Analgesics; Animals; Blood-Brain Barrier; Brain; Drug Carriers; Injections, Intravenous; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Thiorphan | 1995 |
Hypoalgesic action of bestatin analogues that inhibit central aminopeptidases, but not neutral endopeptidase.
Topics: Aminopeptidases; Analgesics; Animals; Cycloleucine; Drug Interactions; Enkephalin, Methionine; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Protease Inhibitors; Thiorphan | 1993 |
Analgesic potency of S-acetylthiorphan after intravenous administration to mice.
Topics: Analgesics; Animals; Injections, Intravenous; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Thiorphan | 1993 |
Action of enkephalinase (EC 3.4.24.11) inhibition on the pre- and post-prandial electromyographic patterns of colon in rats.
Topics: Animals; Cecum; Colon; Eating; Electromyography; Endorphins; Gastrointestinal Motility; Male; Membrane Proteins; Naloxone; Neprilysin; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 1993 |
Inhaled FMLP increases microvascular permeability in the rabbit trachea.
Topics: Administration, Inhalation; Angiotensin II; Animals; Atropine; Blood Pressure; Capillary Permeability; Evans Blue; Male; Morphine; N-Formylmethionine Leucyl-Phenylalanine; Naloxone; Neprilysin; Rabbits; Regional Blood Flow; Thiorphan; Trachea | 1993 |
Antitumor activity of bestatin and thiorphan in mice.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Female; Killer Cells, Natural; Leucine; Macrophages; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Naloxone; Protease Inhibitors; Thiorphan | 1995 |
Peptidase inhibitor-induced antidiuresis mediated through angiotensin and opioid receptors in the rat hypothalamus.
Topics: Aminopeptidases; Angiotensin II; Animals; Carboxypeptidases; Diuresis; Hemodynamics; Hypothalamus; Leucine; Male; Naloxone; Protease Inhibitors; Rats; Rats, Wistar; Receptors, Angiotensin; Receptors, Opioid; Thiorphan | 1996 |
Central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats.
Topics: Analysis of Variance; Animals; Cold Temperature; Enkephalin, Methionine; Gastric Mucosa; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Protease Inhibitors; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Stress, Physiological; Thiorphan | 1996 |
The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds.
Topics: Abdominal Muscles; Acetic Acid; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclobutanes; Dothiepin; Male; Maprotiline; Mice; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Neprilysin; Neurotransmitter Uptake Inhibitors; Opioid Peptides; Pain Measurement; Paroxetine; Protease Inhibitors; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors; Thiorphan | 1998 |
Inhibitory actions of nociceptin (orphanin FQ) on rat supraoptic nucleus oxytocin and vasopressin neurones in vitro.
Topics: Animals; Evoked Potentials; Female; In Vitro Techniques; Leucine; Membrane Potentials; Naloxone; Narcotic Antagonists; Neurons; Nociceptin; Opioid Peptides; Oxytocin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Supraoptic Nucleus; Thiorphan; Vasopressins | 1998 |
Cholecystokinin receptor agonists block the jumping behaviour precipitated in morphine-dependent mice by naloxone.
Topics: Animals; Ceruletide; Devazepide; Dose-Response Relationship, Drug; Hormone Antagonists; Male; Mice; Morphine Dependence; Motor Activity; Naloxone; Narcotic Antagonists; Pyrazoles; Receptors, Cholecystokinin; Substance Withdrawal Syndrome; Tetragastrin; Thiorphan | 1999 |
Racecadotril demonstrates intestinal antisecretory activity in vivo.
Topics: Animals; Antidiarrheals; Cholera Toxin; Dogs; Intestinal Mucosa; Naloxone; Neprilysin; Phentolamine; Protease Inhibitors; Thiorphan | 1999 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions.
Topics: Amphetamine; Animals; Brain Chemistry; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Endorphins; Extracellular Space; Injections, Intraperitoneal; Male; Microdialysis; Microinjections; Naloxone; Narcotic Antagonists; Neostriatum; Nucleus Accumbens; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tegmentum Mesencephali; Thiorphan | 2002 |