thiorphan has been researched along with enkephalin, methionine in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (61.02) | 18.7374 |
| 1990's | 17 (28.81) | 18.2507 |
| 2000's | 5 (8.47) | 29.6817 |
| 2010's | 1 (1.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hughes, TK; Paemen, LR; Stefano, GB | 1 |
| Benoliel, JJ; Bourgoin, S; Cesselin, F; Hamon, M; Legrand, JC; Mauborgne, A | 1 |
| Gintzler, AR; Sublette, E | 1 |
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Frank, C; Proietti, ML; Sagratella, S; Scotti de Carolis, A; Trampus, M | 1 |
| Ishikawa, K; Martinez, JL; Shibanoki, S; Weinberger, SB | 1 |
| Suh, HH; Tseng, LL | 1 |
| Houdi, AA; Van Loon, GR | 1 |
| Borson, DB; Caughey, G; Corrales, R; Gold, M; Nadel, JA; Ramachandran, J; Varsano, S; Viro, N | 1 |
| Chipkin, RE; Yaksh, TL | 1 |
| Livett, BG; Marley, PD; Mitchelhill, KI | 1 |
| Autry, WL; Barbaz, BS; Norman, JA | 1 |
| Aoki, K; Kajiwara, M; Oka, T | 1 |
| Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Buéno, L; Liberge, M; Rivière, PM | 1 |
| Krielaart, MJ; Tijms, RP; van Amsterdam, JG; van Buuren, KJ; Zuiderveld, OP | 1 |
| Chariot, J; Chicau-Chovet, M; Dubrasquet, M; Lecomte, JM; Rozé, C; Tsocas, A | 1 |
| Aoyagi, T; Hachisu, M; Hiranuma, T; Murata, S; Umezawa, H | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T | 1 |
| Artaud, F; Bouboutou, R; Bourgoin, S; Cesselin, F; Clot, AM; Fournie-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Han, JS; Jin, WQ; Zhou, ZF | 2 |
| Chaillet, P; Costentin, J; Leboyer, M; Lecomte, JM; Llorens-Cortes, C; Marcais-Collado, H; Schwartz, JC; Vlaiculescu, A | 1 |
| Hiranuma, T; Oka, T | 1 |
| Bouboutou, R; Bourgoin, S; Cesselin, F; Devin, J; Fournie-Zaluski, MC; Hamon, M; Roques, B; Waksman, G | 1 |
| Beckman, AL; Sartin, NF; Stanton, TL | 1 |
| Han, JS; Yuan, H | 1 |
| Buéno, L; Fargeas, MJ; Fioramonti, J | 1 |
| Gros, C; Llorens-Cortes, C; Schwartz, JC | 1 |
| Chou, J; Costa, E; Del Rio, J; Tang, J; Yang, HY | 1 |
| Cohen, ML; Geary, LE; Scott, WL; Wiley, KS | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP | 1 |
| Billard, W; Chipkin, RE; Kreutner, W | 1 |
| Bouboutou, R; Chaillet, P; Cherot, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Waksman, G | 1 |
| Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A | 1 |
| de la Baume, S; Giros, B; Gros, C; Schwartz, JC | 1 |
| Chaillet, P; Costentin, J; Lecomte, JM; Marçais, H; Natan, LB; Uchida, G | 1 |
| Giovino, AA; Glimcher, PW; Hoebel, BG; Margolin, DH | 1 |
| de Groat, WC; Hisamitsu, T | 1 |
| Costa, E; Yang, HY; Zhang, AZ | 1 |
| Costa, E; Harsing, LG; Majane, EM; Yang, HY | 1 |
| Barnett, A; Chipkin, RE; Iorio, LC; Latranyi, MZ | 1 |
| De La Baume, S; Fournie-Zaluski, MC; Gros, C; Patey, G; Roques, B; Schwartz, JC; Soroca-Lucas, E | 1 |
| Harty, GJ; Yaksh, TL | 1 |
| Adjroud, O | 1 |
| Amidon, GL; Langguth, P; Nadai, T; Sakane, T; Sezaki, H; Taki, Y; Yamashita, S | 1 |
| Coupar, IM; Hancock, DL | 1 |
| Botyánszki, J; Fehér, E; Hepp, J; Magyar, A; Medzihradszky, K; Rónai, AZ | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Fuentes, JA; Iglesias, T; Otero, MJ | 1 |
| Haberstock, H; Marotti, T | 1 |
| Parenti, C; Scoto, GM | 1 |
| Mizoguchi, H; Nagase, H; Narita, M; Tseng, LF | 1 |
| Adem, A; Elhassan, AM; Gad, A; Lindgren, JU; Papadogiannakis, N; Suliman, I | 1 |
| Bourgoin, S; Cesselin, F; Mauborgne, A; Poliénor, H; Roumy, M; Simonnet, G; Zajac, JM | 1 |
| Boranić, M; Gabrilovac, J; Kusec, R; Martin-Kleiner, I | 1 |
| Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
| Dang, VC; Williams, JT | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
59 other study(ies) available for thiorphan and enkephalin, methionine
| Article | Year |
|---|---|
Autoimmunoregulation: differential modulation of CD10/neutral endopeptidase 24.11 by tumor necrosis factor and neuropeptides.
Topics: Animals; Autoimmunity; Bivalvia; Dose-Response Relationship, Immunologic; Enkephalin, Methionine; Gene Expression Regulation; Glycopeptides; Granulocytes; Hemocytes; Humans; In Vitro Techniques; Melanocyte-Stimulating Hormones; Neprilysin; Neuropeptides; Substance P; Thiorphan; Tumor Necrosis Factor-alpha | 1992 |
Opioid control of the in vitro release of cholecystokinin-like material from the rat substantia nigra.
Topics: Animals; Calcium; Cholecystokinin; Endorphins; Enkephalin, Methionine; In Vitro Techniques; Leucine; Ligands; Male; Potassium; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Substantia Nigra; Thiorphan | 1992 |
Stimulus frequency and intensity: critical determinants of opioid enhancement or inhibition of evoked methionine-enkephalin release.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Captopril; Cyclic AMP; Dipeptides; Electric Stimulation; Enkephalin, Methionine; Guinea Pigs; In Vitro Techniques; Leucine; Muscle, Smooth; Myenteric Plexus; Protease Inhibitors; Pyrrolidines; Thiorphan | 1992 |
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
An in vitro study on the hippocampal electrophysiological properties of enkephalinase inhibitors in rats.
Topics: Animals; Dipeptides; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Neprilysin; Perfusion; Rats; Rats, Inbred Strains; Thiorphan | 1991 |
HPLC-ECD determination of the enzymatic hydrolysis of [leu]- and [met]enkephalin in rat plasma.
Topics: Acetylcholinesterase; Aminopeptidases; Animals; Captopril; CD13 Antigens; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Leucine; Male; Oligopeptides; Rats; Rats, Inbred Strains; Thiorphan; Tyrosine | 1990 |
Intrathecal administration of thiorphan and bestatin enhances the antinociception and release of Met-enkephalin induced by beta-endorphin intraventricularly in anesthetized rats.
Topics: Aminopeptidases; Anesthesia; Animals; beta-Endorphin; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Leucine; Male; Nociceptors; Pain Measurement; Rats; Rats, Inbred Strains; Tail; Thiorphan | 1990 |
Haloperidol-induced increase in striatal concentration of the tripeptide, Tyr-Gly-Gly, provides an index of increased enkephalin release in vivo.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Haloperidol; Immune Sera; Male; Neprilysin; Oligopeptides; Osmolar Concentration; Radioimmunoassay; Rats; Rats, Inbred Strains; Thiorphan; Time Factors; Tissue Distribution | 1990 |
Enkephalinase inhibitors potentiate substance P-induced secretion of 35SO4-macromolecules from ferret trachea.
Topics: Animals; Drug Synergism; Endopeptidases; Enkephalin, Methionine; Ferrets; Glycopeptides; In Vitro Techniques; Male; Molecular Weight; Mucus; Neprilysin; Protease Inhibitors; Rabbits; Substance P; Sulfates; Thiorphan; Tiopronin; Trachea | 1987 |
Studies on the effect of SCH-34826 and thiorphan on [Met5]enkephalin levels and release in rat spinal cord.
Topics: Analgesics; Animals; Brain Chemistry; Dioxolanes; Dioxoles; Dipeptides; Enkephalin, Methionine; Male; Potassium; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1989 |
Effects of opioid peptides containing the sequence of Met5-enkephalin or Leu5-enkephalin on nicotine-induced secretion from bovine adrenal chromaffin cells.
Topics: Adenosine Triphosphate; Adrenal Medulla; Amino Acid Sequence; Animals; Bacitracin; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guinea Pigs; Leucine; Nicotine; Norepinephrine; Peptide Fragments; Phenanthrolines; Rabbits; Receptors, Opioid; Thiorphan; Tiopronin | 1986 |
Angiotensin-converting enzyme inhibitors potentiate the analgesic activity of [Met]-enkephalin-Arg6-Phe7 by inhibiting its degradation in mouse brain.
Topics: Analgesics; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Captopril; Enalapril; Enalaprilat; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Peptidyl-Dipeptidase A; Synaptic Membranes; Thiorphan; Tiopronin | 1985 |
The inactivation of [Met5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens.
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Captopril; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Neprilysin; Peptidyl-Dipeptidase A; Phenylalanine; Thiorphan; Tiopronin; Vas Deferens | 1986 |
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin | 1986 |
Influence of enkephalinase inhibitors on gastric emptying in mice depends on the nature of the meal.
Topics: Amino Acids, Sulfur; Animals; Dietary Fats; Enkephalin, Methionine; Gastric Emptying; Male; Mice; Thiorphan; Tiopronin | 1988 |
Effect of inhibitors of enkephalin degradation in the isolated guinea-pig ileum.
Topics: Animals; Buffers; Dipeptides; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Thiorphan | 1988 |
Thiorphan and acetorphan inhibit gastric secretion by a central, non-opioid mechanism in the rat.
Topics: Animals; Drug Interactions; Enkephalin, Methionine; Gastric Acid; Gastric Mucosa; Male; Neprilysin; Pentagastrin; Prodrugs; Rats; Rats, Inbred Strains; Thiorphan | 1988 |
Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes.
Topics: Aminopeptidases; Analgesia; Animals; Corpus Striatum; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Synergism; Endopeptidases; Enkephalin, Methionine; Guinea Pigs; Hydroxamic Acids; Male; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin | 1987 |
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility).
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin | 1988 |
Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord.
Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Methionine; Leucine; Male; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1986 |
Electroacupuncture and morphine analgesia potentiated by bestatin and thiorphan administered to the nucleus accumbens of the rabbit.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Immune Sera; Leucine; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Rabbits; Septal Nuclei; Thiorphan; Time Factors; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1986 |
Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Antidiarrheals; Biogenic Amines; Brain Chemistry; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Injections; Kinetics; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1986 |
Effects of peptidase inhibitors on the [Met5]-enkephalin hydrolysis in ileal and striatal preparations of guinea-pig: almost complete protection of degradation by the combination of amastatin, captopril and thiorphan.
Topics: Animals; Anti-Bacterial Agents; Captopril; Corpus Striatum; Enkephalin, Methionine; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Male; Membranes; Oligopeptides; Peptides; Protease Inhibitors; Thiorphan; Tiopronin | 1986 |
In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain.
Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Corpus Striatum; Dipeptides; Enkephalin, Methionine; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Mice; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1985 |
Changes in body temperature and metabolic rate following microinjection of Met-enkephalinamide in the preoptic/anterior hypothalamus of rats.
Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Enkephalin, Methionine; Male; Metabolic Clearance Rate; Microinjections; Naloxone; Preoptic Area; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1985 |
[Electroacupuncture accelerates the biogenesis of central enkephalins in the rat].
Topics: Acupuncture Therapy; Aminopeptidases; Animals; Brain; Electric Stimulation Therapy; Enkephalin, Leucine; Enkephalin, Methionine; Female; Leucine; Male; Phenylalanine; Radioimmunoassay; Rats; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1985 |
Enhancement of colonic motor response to feeding by central endogenous opiates in the dog.
Topics: Animals; Colon; Dogs; Eating; Endorphins; Enkephalin, Methionine; Female; Gastrointestinal Motility; Humans; Mice; Naltrexone; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin | 1985 |
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors.
Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Mice; Microwaves; Nalorphine; Neprilysin; Oligopeptides; Protease Inhibitors; Radioimmunoassay; Thiorphan; Tiopronin | 1985 |
[Inhibition of enkephalins degradation in the nucleus accumbens leads to potentiation of acupuncture and morphine analgesia].
Topics: Acupuncture Therapy; Aminopeptidases; Analgesia; Animals; Electric Stimulation Therapy; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Morphine; Neprilysin; Nucleus Accumbens; Protease Inhibitors; Rabbits; Septal Nuclei; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1985 |
Action of peptidase inhibitors on methionine5-enkephalin-arginine6-phenylalanine7 (YGGFMRF) and methionine5-enkephalin (YGGFM) metabolism and on electroacupuncture antinociception.
Topics: Acupuncture Therapy; Analgesia; Animals; Captopril; Electronarcosis; Enkephalin, Methionine; Leucine; Male; Perfusion; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Thiorphan; Tiopronin | 1984 |
Degradation of exogenous enkephalin in the guinea-pig ileum: relative importance of aminopeptidase, enkephalinase and angiotensin converting enzyme activity.
Topics: Aminopeptidases; Angiotensin I; Animals; Bradykinin; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1982 |
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1983 |
Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor.
Topics: Amino Acids, Sulfur; Animals; Blood Glucose; Brain; Drug Synergism; Enkephalin, Methionine; Insulin; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1984 |
Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kidney; Leucine; Neprilysin; Protease Inhibitors; Rabbits; Rats; Reaction Time; Thiorphan; Tiopronin | 1984 |
Effect of bestatin and thiorphan on [Met5]enkephalin-Arg6-Phe7-induced analgesia.
Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesia; Animals; Enkephalin, Methionine; Leucine; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1984 |
[Inhibition of the evoked liberation of (Met5)enkephalin from slices of globus pallidus in the presence of thiorphan and bestatin].
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Electric Stimulation; Enkephalin, Methionine; Globus Pallidus; In Vitro Techniques; Leucine; Potassium Chloride; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1983 |
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test.
Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
Endogenous opiate reward induced by an enkephalinase inhibitor, thiorphan, injected into the ventral midbrain.
Topics: Amino Acids, Sulfur; Animals; Endorphins; Enkephalin, Methionine; Female; Mesencephalon; Naloxone; Rats; Rats, Inbred Strains; Reward; Tegmentum Mesencephali; Thiorphan; Tiopronin | 1984 |
The inhibitory effect of opioid peptides and morphine applied intrathecally and intracerebroventricularly on the micturition reflex in the cat.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Morphine; Naloxone; Oligopeptides; Reflex; Thiorphan; Tiopronin; Urination | 1984 |
Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors.
Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Enkephalins; Exopeptidases; Female; Leucine; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin | 1982 |
Possible role of dipeptidyl carboxypeptidase n the metabolism of Met5-enkephalin and Met5-enkephalin-Arg6-Phe7.
Topics: Animals; Captopril; Cattle; Chlorides; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1982 |
Potentiation of [D-ala2]enkephalinamide analgesia in rats by thiorphan.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Drug Synergism; Enkephalin, Methionine; Male; Naloxone; Neprilysin; Nociceptors; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Time Factors; Tiopronin | 1982 |
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.
Topics: Amino Acids, Sulfur; Animals; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Neprilysin; Potassium; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1981 |
Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5] enkephalin.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Captopril; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Injections, Spinal; Macaca; Morphine; Neprilysin; Protease Inhibitors; Rats; Species Specificity; Thiorphan; Tiopronin | 1982 |
Peripheral excitatory effects of two enkephalinase inhibitors, acetorphan and thiorphan, and an enkephalin analogue, [D-Ala2-Met5]-enkephalinamide, on uterine motility in periparturient rats in vivo and in vitro.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Female; Naloxone; Narcotic Antagonists; Neprilysin; Neurotransmitter Agents; Pregnancy; Protease Inhibitors; Rats; Rats, Wistar; Stimulation, Chemical; Thiorphan; Uterine Contraction | 1995 |
Gastrointestinal absorption of peptide drug: quantitative evaluation of the degradation and the permeation of metkephamid in rat small intestine.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Biological Availability; Enkephalin, Methionine; Intestinal Absorption; Intestine, Small; Leucine; Male; Molecular Sequence Data; Puromycin; Rats; Rats, Wistar; Thiorphan | 1995 |
Evidence for peptidase activity in the rat intestine.
Topics: Amino Acid Sequence; Animals; Drug Tolerance; Enkephalin, Methionine; Female; In Vitro Techniques; Intestines; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Opioid Peptides; Parasympathetic Nervous System; Peptide Hydrolases; Protease Inhibitors; Rats; Rats, Wistar; Thiorphan; Time Factors | 1995 |
Substrate- and inhibitor-specificity of a non-endothelial enzyme which forms [Met5]-enkephalin from [Met5]-enkephalin-Arg6,Phe7 in isolated rabbit ear artery: pharmacological characterization.
Topics: Amino Acid Sequence; Angiotensin I; Animals; Arteries; Bradykinin; Captopril; Disease Models, Animal; Ear, External; Enalapril; Endopeptidases; Endothelium, Vascular; Enkephalin, Methionine; Male; Migraine Disorders; Molecular Sequence Data; Rabbits; Substrate Specificity; Thiorphan | 1995 |
Effect of some peptidase inhibitors on exogenous and endogenous opioid actions in guinea-pig ileum.
Topics: Aminopeptidases; Animals; Bacitracin; Captopril; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; Leucine; Male; Morphine; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Thiorphan | 1994 |
Hypoalgesic action of bestatin analogues that inhibit central aminopeptidases, but not neutral endopeptidase.
Topics: Aminopeptidases; Analgesics; Animals; Cycloleucine; Drug Interactions; Enkephalin, Methionine; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Neprilysin; Pain Measurement; Protease Inhibitors; Thiorphan | 1993 |
The relevance of intact enkephalin molecule in predominantly delta opioid receptor mediated superoxide anion release.
Topics: Adult; Anions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Neprilysin; Neutrophils; Oligopeptides; Protease Inhibitors; Receptors, Opioid, delta; Superoxides; Thiorphan | 1995 |
Central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats.
Topics: Analysis of Variance; Animals; Cold Temperature; Enkephalin, Methionine; Gastric Mucosa; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Protease Inhibitors; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Stress, Physiological; Thiorphan | 1996 |
Use of antisense oligodeoxynucleotide to delta-opioid receptor mRNA in the study of turnover of delta-opioid receptors in the spinal cord of the mouse.
Topics: Animals; Enkephalin, Methionine; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Oligopeptides; Pain Measurement; Protease Inhibitors; Receptors, Opioid, delta; RNA, Messenger; Spinal Cord; Thiorphan | 1997 |
Intracerebroventricular met-enkephalin administration modulates adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cerebral Ventricles; Disease Models, Animal; Enkephalin, Methionine; Female; Inflammation; Injections, Intraventricular; Neprilysin; Rats; Rats, Inbred Lew; Thiorphan | 2000 |
The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord.
Topics: Animals; Autoreceptors; Dose-Response Relationship, Drug; Enkephalin, Methionine; In Vitro Techniques; Leucine; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiorphan | 2001 |
Methionine enkephalin suppresses metabolic activity of a leukemic cell line (NALM-1) and enhances CD10 expression.
Topics: Cell Line, Tumor; DNA, Complementary; Enkephalin, Methionine; Humans; Leukemia; Neprilysin; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thiorphan | 2003 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
Chronic morphine treatment reduces recovery from opioid desensitization.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cocaine; Drug Tolerance; Enkephalin, Methionine; Leucine; Locus Coeruleus; Male; Monensin; Morphine; Morphine Dependence; Morphine Derivatives; Norepinephrine; Phosphorylation; Prazosin; Protein Kinase C; Protein Processing, Post-Translational; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Staurosporine; Thiorphan; Yohimbine | 2004 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |