thiorphan has been researched along with enkephalin, leucine in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (70.00) | 18.7374 |
| 1990's | 15 (21.43) | 18.2507 |
| 2000's | 3 (4.29) | 29.6817 |
| 2010's | 2 (2.86) | 24.3611 |
| 2020's | 1 (1.43) | 2.80 |
| Authors | Studies |
|---|---|
| Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP | 1 |
| Froehlich, JC; Harts, J; Li, TK; Lumeng, L; Zweifel, M | 1 |
| Bousselmame, R; Costentin, J; Michael-Titus, A | 1 |
| Back, SA; Gorenstein, C | 1 |
| Azerad, J; Desmonts, JM; Limoge, A; Mantz, J | 1 |
| Baas, AA; Dzoljic, MM; Dzoljic, MR; Rupreht, J; Ukponmwan, OE; van den Berg, DJ | 1 |
| Frank, C; Proietti, ML; Sagratella, S; Scotti de Carolis, A; Trampus, M | 1 |
| Ishikawa, K; Martinez, JL; Shibanoki, S; Weinberger, SB | 1 |
| Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Herz, A; Parsons, CG | 1 |
| Houdi, AA; Van Loon, GR | 1 |
| Kehl, LJ | 1 |
| Borson, DB; Djokic, TD; Nadel, JA; Sekizawa, K | 1 |
| Delay-Goyet, P; Meucci, E; Roques, BP; Zajac, JM | 1 |
| Bouvier, M; Grimaud, JC; Naudy, B; Salducci, J | 1 |
| Caline, H; Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Livett, BG; Marley, PD; Mitchelhill, KI | 1 |
| Dzoljic, MR; Haffmans, J; van Amsterdam, JC; Walsum, MV | 1 |
| Martinez, JL; Weinberger, SB | 1 |
| Cadden, S; Chitour, D; Le Bars, D; Villanueva, L | 1 |
| Roques, BP | 1 |
| Kalivas, PW; Richardson-Carlson, R | 1 |
| Ernst, M; Roby, A; Willer, JC | 1 |
| Buéno, L; Fioramonti, J | 1 |
| Giros, B; Gros, C; Llorens-Cortes, C; Schwartz, JC | 1 |
| Costentin, J; Giros, B; Michael-Titus, A; Preterre, P | 1 |
| Martinez, JL; Walker, RC; Weinberger, SB; Zafuto, CE | 1 |
| Gros, C; Llorens-Cortes, C; Schwartz, JC | 2 |
| Chaussade, S; Couturier, D; Guerre, J; Hamm, R; Lecomte, JM | 1 |
| Kameyama, T; Katoh, A; Nabeshima, T | 1 |
| Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF | 1 |
| Costentin, J; Danvy, D; Duhamel, L; Duhamel, P; Giros, B; Gros, C; Lecomte, JM; Plaquevent, JC; Schwartz, JC; Vlaiculescu, A | 1 |
| Bouboutou, R; Bourgoin, S; Cesselin, F; Devin, J; Fournie-Zaluski, MC; Hamon, M; Roques, B; Waksman, G | 1 |
| Han, JS; Yuan, H | 1 |
| Frederickson, RC; Johnson, BG; Mendelsohn, LG; Scott, WL | 1 |
| Deschodt-Lanckman, M | 1 |
| Han, JS; Jin, WQ; Zhou, ZF | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Zajac, JM | 1 |
| Aoki, K; Kajiwara, M; Oka, T | 1 |
| Cohen, ML; Geary, LE; Scott, WL; Wiley, KS | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP | 1 |
| Brandt, U; Lentzen, H; Palenker, J | 1 |
| Amano, H; Kaneko, S; Morimoto, Y; Takagi, H | 1 |
| Lentzen, H; Palenker, J | 1 |
| Chaillet, P; Costentin, J; de la Baume, S; Marcais-Collado, H; Schwartz, JC; Yi, CC | 2 |
| Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A | 1 |
| Bouboutou, R; Chaillet, P; Cherot, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Waksman, G | 1 |
| Soudijn, W; van Amsterdam, JG; van Buuren, KJ | 1 |
| Chaillet, P; Costentin, J; Lecomte, JM; Marçais, H; Natan, LB; Uchida, G | 1 |
| de Groat, WC; Hisamitsu, T | 1 |
| Llorens-Cortes, C; Schwartz, JC | 1 |
| Costa, E; Yang, HY; Zhang, AZ | 1 |
| Barnett, A; Berger, J; Billard, W; Chipkin, RE; Iorio, LC | 1 |
| Wood, PL | 1 |
| Fournié-Zaluski, MC; Lecomte, JM; Llorens, C; Malfroy, B; Roques, BP; Schwartz, JC; Soroca, E | 1 |
| De La Baume, S; Fournie-Zaluski, MC; Gros, C; Patey, G; Roques, B; Schwartz, JC; Soroca-Lucas, E | 1 |
| Harty, GJ; Yaksh, TL | 1 |
| Fulcher, IS; Kenny, AJ; Matsas, R; Turner, AJ | 1 |
| Haberstock, H; Marotti, T | 1 |
| Ekström, G; Krondahl, E; Lennernäs, H; Orzechowski, A | 1 |
| Anderson, L; Bussler, B; Dufton, M; Martins, H | 1 |
| Boileau, G; Carpentier, M; Crine, P; Desgroseillers, L; Ghaddar, G; Marcinkiewicz, M; Ruchon, AF; Seidah, NG | 1 |
| Fournel, S; Nano, JL; Rampal, P | 1 |
| Gross, GJ; Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV; Stephano, JB | 1 |
| Chang, CH; Chang, CK; Cheng, JT; Cheng, KC; Wu, HT; Yeh, CH | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
| Bagley, EE; Gregoriou, GC; Patel, SD; Winters, BL | 1 |
2 review(s) available for thiorphan and enkephalin, leucine
| Article | Year |
|---|---|
[Enkephalinase inhibitors and molecular study of the differences between active sites of enkephalinase and angiotensin-converting enzyme].
Topics: Analgesics; Animals; Binding Sites; Drug Synergism; Endopeptidases; Enkephalins; Humans; Metalloendopeptidases; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Sulfhydryl Compounds; Thiorphan; Tiopronin | 1985 |
Enkephalins, other endogenous opioids and colonic motility in dog and man.
Topics: Animals; Central Nervous System; Colon; Dogs; Endorphins; Enkephalins; Gastrointestinal Motility; Humans; In Vitro Techniques; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Species Specificity; Thiorphan; Tiopronin | 1987 |
1 trial(s) available for thiorphan and enkephalin, leucine
| Article | Year |
|---|---|
Effects of an enkephalinase inhibitor on esophageal motility in man.
Topics: Enkephalins; Esophagogastric Junction; Esophagus; Humans; Manometry; Neprilysin; Peristalsis; Random Allocation; Thiorphan | 1988 |
67 other study(ies) available for thiorphan and enkephalin, leucine
| Article | Year |
|---|---|
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan | 1992 |
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan | 1992 |
Importance of delta opioid receptors in maintaining high alcohol drinking.
Topics: Alcohol Drinking; Animals; Drinking Behavior; Enkephalin, Leucine; Male; Naloxone; Narcotic Antagonists; Neprilysin; Phenylpropionates; Rats; Receptors, Opioid; Receptors, Opioid, delta; Thiorphan | 1991 |
Desensitization of mu-opioid receptors does not modify the analgesia induced by an enkephalinase inhibitor.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Neprilysin; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan | 1991 |
Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat brainstem.
Topics: Animals; Brain Stem; Enkephalins; Enzyme Inhibitors; Glycopeptides; Histocytochemistry; Male; Neprilysin; Rats; Rats, Inbred Strains; Substance P; Thiorphan | 1990 |
Transcranial electrical stimulation with Limoge's currents decreases halothane requirements in rats. Evidence for the involvement of endogenous opioids.
Topics: Anesthesia, Inhalation; Animals; Electric Stimulation; Enkephalins; Halothane; Male; Methysergide; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Ritanserin; Thiorphan; Yohimbine | 1992 |
Suppressive effects of enkephalins and REM sleep deprivation on seizures.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Enkephalins; Glycopeptides; Leucine; Male; Mice; Mice, Inbred Strains; Neprilysin; Nitrous Oxide; Rats; Rats, Inbred Strains; Sleep Deprivation; Sleep, REM; Substance Withdrawal Syndrome; Thiorphan | 1991 |
An in vitro study on the hippocampal electrophysiological properties of enkephalinase inhibitors in rats.
Topics: Animals; Dipeptides; Electric Stimulation; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Neprilysin; Perfusion; Rats; Rats, Inbred Strains; Thiorphan | 1991 |
HPLC-ECD determination of the enzymatic hydrolysis of [leu]- and [met]enkephalin in rat plasma.
Topics: Acetylcholinesterase; Aminopeptidases; Animals; Captopril; CD13 Antigens; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Leucine; Male; Oligopeptides; Rats; Rats, Inbred Strains; Thiorphan; Tyrosine | 1990 |
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice.
Topics: Aminopeptidases; Animals; CD13 Antigens; Dipeptides; Drug Synergism; Enkephalin, Leucine; Enkephalins; Injections, Intravenous; Injections, Intraventricular; Leucine; Locomotion; Male; Mice; Naloxone; Neprilysin; Phenylcarbamates; Prodrugs; Receptors, Opioid; Receptors, Opioid, delta; Sulfhydryl Compounds; Thiorphan | 1990 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming; Thiorphan | 1990 |
Haloperidol-induced increase in striatal concentration of the tripeptide, Tyr-Gly-Gly, provides an index of increased enkephalin release in vivo.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Haloperidol; Immune Sera; Male; Neprilysin; Oligopeptides; Osmolar Concentration; Radioimmunoassay; Rats; Rats, Inbred Strains; Thiorphan; Time Factors; Tissue Distribution | 1990 |
Analgesia after inhibition of enkephalin degradation.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Neprilysin; Protease Inhibitors; Spinal Cord; Substance P; Thiorphan; Tiopronin | 1986 |
Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle.
Topics: Animals; Drug Synergism; Duodenum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ferrets; Glycopeptides; Ileum; Intestines; Male; Muscle Contraction; Protease Inhibitors; Rats; Substance P; Thiorphan | 1989 |
Binding in vivo of selective mu and delta opioid receptor agonists: opioid receptor occupancy by endogenous enkephalins.
Topics: Animals; Brain; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hydroxamic Acids; In Vitro Techniques; Injections; Kinetics; Male; Mice; Morphine; Oligopeptides; Phenylalanine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan | 1989 |
Non-cholinergic neural excitation of the human rectum induced by acetorphan, an inhibitor of enkephalinase.
Topics: Adult; Analgesics; Electromyography; Enkephalins; Female; Hirschsprung Disease; Humans; Male; Neprilysin; Rectum; Stimulation, Chemical; Thiorphan | 1989 |
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Pain; Protease Inhibitors; Reference Values; Species Specificity; Thiorphan | 1989 |
Effects of opioid peptides containing the sequence of Met5-enkephalin or Leu5-enkephalin on nicotine-induced secretion from bovine adrenal chromaffin cells.
Topics: Adenosine Triphosphate; Adrenal Medulla; Amino Acid Sequence; Animals; Bacitracin; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guinea Pigs; Leucine; Nicotine; Norepinephrine; Peptide Fragments; Phenanthrolines; Rabbits; Receptors, Opioid; Thiorphan; Tiopronin | 1986 |
Phelorphan, an inhibitor of enzymes involved in the biodegradation of enkephalins, affected the withdrawal symptoms in chronic morphine-dependent rats.
Topics: Aminopeptidases; Animals; Brain; CD13 Antigens; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Male; Morphine Dependence; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome; Thiorphan; Tiopronin | 1987 |
Characterization of hydrolysis of [leu]enkephalin and D-ala2-[L-leu]enkephalin in rat plasma.
Topics: Aminopeptidases; Animals; CD13 Antigens; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Half-Life; Hydrolysis; Leucine; Male; Neprilysin; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Strains; Thiorphan | 1988 |
Failure of ES 52, a highly potent enkephalinase inhibitor, to affect nociceptive transmission by rat dorsal horn convergent neurones.
Topics: Amino Acids, Sulfur; Animals; Enkephalins; Male; Nociceptors; Pain; Rats; Spinal Cord; Synaptic Transmission; Thiorphan; Tiopronin | 1985 |
Endogenous enkephalin modulation of dopamine neurons in ventral tegmental area.
Topics: Animals; Behavior, Animal; Dopamine; Enkephalins; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali; Thiorphan; Tiopronin | 1986 |
The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans.
Topics: Adult; Amino Acids, Sulfur; Electric Stimulation; Endopeptidases; Enkephalins; Female; Humans; Male; Middle Aged; Neprilysin; Pain; Protease Inhibitors; Recruitment, Neurophysiological; Reflex; Spinal Cord; Sural Nerve; Synaptic Transmission; Thiorphan; Tiopronin | 1986 |
[Opioid peptides: metabolism and receptors].
Topics: Animals; Brain; Cattle; Endopeptidases; Endorphins; Enkephalins; Humans; Leucine; Mice; Neprilysin; Pro-Opiomelanocortin; Protease Inhibitors; Protein Precursors; Receptors, Opioid; Thiorphan; Tiopronin | 1987 |
Role of endogenous enkephalins in locomotion evidenced by acetorphan, an "enkephalinase" inhibitor.
Topics: Amino Acids, Sulfur; Animals; Dose-Response Relationship, Drug; Enkephalins; Hydroxydopamines; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thiorphan; Tiopronin | 1987 |
Characterization of enkephalin degradation in rat plasma.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Leucine; Enkephalins; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1986 |
Evaluation of striatal enkephalin release in vivo from steady state levels and turnover rates of the tripeptide Tyr-Gly-Gly.
Topics: Animals; Anti-Bacterial Agents; Corpus Striatum; Enkephalins; In Vitro Techniques; Kinetics; Leucine; Male; Mice; Oligopeptides; Pentobarbital; Thiorphan; Tiopronin | 1986 |
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility).
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin | 1988 |
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1987 |
Enantiomers of thiorphan and acetorphan: correlation between enkephalinase inhibition, protection of endogenous enkephalins and behavioral effects.
Topics: Amino Acids, Sulfur; Analgesia; Angiotensin-Converting Enzyme Inhibitors; Animals; Corpus Striatum; Enkephalins; Globus Pallidus; In Vitro Techniques; Male; Metalloendopeptidases; Mice; Motor Activity; Neprilysin; Rats; Rats, Inbred Strains; Stereoisomerism; Thermolysin; Thiorphan; Tiopronin | 1987 |
In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain.
Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Corpus Striatum; Dipeptides; Enkephalin, Methionine; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Mice; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1985 |
[Electroacupuncture accelerates the biogenesis of central enkephalins in the rat].
Topics: Acupuncture Therapy; Aminopeptidases; Animals; Brain; Electric Stimulation Therapy; Enkephalin, Leucine; Enkephalin, Methionine; Female; Leucine; Male; Phenylalanine; Radioimmunoassay; Rats; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1985 |
Thiorphan and analogs: lack of correlation between potency to inhibit "enkephalinase A" in vitro and analgesic potency in vivo.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Enkephalins; In Vitro Techniques; Male; Mice; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Stereoisomerism; Thiorphan; Tiopronin | 1985 |
[Enkephalinase, an enzyme in the catabolism of neuropeptides and circulating hormones].
Topics: Brain; Endopeptidases; Enkephalins; Humans; Kidney; Neprilysin; Nerve Tissue Proteins; Thiorphan; Tiopronin | 1985 |
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors.
Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Mice; Microwaves; Nalorphine; Neprilysin; Oligopeptides; Protease Inhibitors; Radioimmunoassay; Thiorphan; Tiopronin | 1985 |
[Inhibition of enkephalins degradation in the nucleus accumbens leads to potentiation of acupuncture and morphine analgesia].
Topics: Acupuncture Therapy; Aminopeptidases; Analgesia; Animals; Electric Stimulation Therapy; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Morphine; Neprilysin; Nucleus Accumbens; Protease Inhibitors; Rabbits; Septal Nuclei; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation | 1985 |
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia.
Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1984 |
The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum.
Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Neprilysin; Oligopeptides; Peptides; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1984 |
Degradation of exogenous enkephalin in the guinea-pig ileum: relative importance of aminopeptidase, enkephalinase and angiotensin converting enzyme activity.
Topics: Aminopeptidases; Angiotensin I; Animals; Bradykinin; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1982 |
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1983 |
Enkephalin degradation by enkephalinergic neuroblastoma cells. Involvement of angiotensin-converting-enzyme.
Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Cell Membrane; Cells, Cultured; Enkephalin, Leucine; Hydrolysis; Leucine; Mice; Neuroblastoma; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1984 |
Opioid activity of enkephalin analogues containing the kyotorphin-related structure in the N-terminus.
Topics: Analgesics; Animals; Brain; Cell Membrane; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Thiorphan; Tiopronin; Vas Deferens | 1984 |
Localization of the thiorphan-sensitive endopeptidase, termed enkephalinase A, on glial cells.
Topics: Aminopeptidases; Animals; Astrocytes; Brain; Cell Membrane; Cells, Cultured; Endopeptidases; Enkephalin, Leucine; Kinetics; Leucine; Neprilysin; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1983 |
Peptidases involved in the inactivation of exogenous and endogenous enkephalins.
Topics: Aminopeptidases; Animals; Brain; Endopeptidases; Enkephalins; Leucine; Mice; Neprilysin; Nociceptors; Rats; Thiorphan; Tiopronin | 1983 |
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats.
Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Species Specificity; Thiorphan; Tiopronin | 1983 |
Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kidney; Leucine; Neprilysin; Protease Inhibitors; Rabbits; Rats; Reaction Time; Thiorphan; Tiopronin | 1984 |
Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor.
Topics: Aminopeptidases; Analgesics; Animals; Brain; Drug Synergism; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Puromycin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin | 1983 |
Purification and characterization of enkephalin-degradating enzymes from calf-brain striatum.
Topics: Aminopeptidases; Animals; Cattle; Corpus Striatum; Dipeptides; Enkephalin, Leucine; Kinetics; Thiorphan; Tiopronin; Tissue Distribution | 1983 |
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test.
Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
The inhibitory effect of opioid peptides and morphine applied intrathecally and intracerebroventricularly on the micturition reflex in the cat.
Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Morphine; Naloxone; Oligopeptides; Reflex; Thiorphan; Tiopronin; Urination | 1984 |
Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin.
Topics: alpha-Methyltyrosine; Amino Acids, Sulfur; Aminopeptidases; Animals; Biogenic Amines; Brain; Enkephalins; Leucine; Male; Methyltyrosines; Mice; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin | 1984 |
Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors.
Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Enkephalins; Exopeptidases; Female; Leucine; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin | 1982 |
In vitro and in vivo effects of thiorphan: an inhibitor of enkephalinase A.
Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesics; Animals; Captopril; Drug Synergism; Enkephalins; In Vitro Techniques; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin | 1982 |
Phasic enkephalinergic modulation of nigrostriatal dopamine metabolism: potentiation with enkephalinase inhibitors.
Topics: Animals; Corpus Striatum; Dopamine; Enkephalins; Hydroxamic Acids; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Substantia Nigra; Thiorphan; Tiopronin | 1982 |
The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Binding Sites; Dose-Response Relationship, Drug; Drug Synergism; Endorphins; Enkephalins; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin | 1980 |
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.
Topics: Amino Acids, Sulfur; Animals; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Neprilysin; Potassium; Protease Inhibitors; Rats; Thiorphan; Tiopronin | 1981 |
Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5] enkephalin.
Topics: Amino Acids, Sulfur; Analgesics; Animals; Captopril; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Injections, Spinal; Macaca; Morphine; Neprilysin; Protease Inhibitors; Rats; Species Specificity; Thiorphan; Tiopronin | 1982 |
Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalins; Glycopeptides; Hydrolysis; Kidney; Neprilysin; Organophosphorus Compounds; Protease Inhibitors; Swine; Synaptic Membranes; Thermolysin; Thiorphan; Tiopronin | 1982 |
The relevance of intact enkephalin molecule in predominantly delta opioid receptor mediated superoxide anion release.
Topics: Adult; Anions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Neprilysin; Neutrophils; Oligopeptides; Protease Inhibitors; Receptors, Opioid, delta; Superoxides; Thiorphan | 1995 |
Rat jejunal permeability and metabolism of mu-selective tetrapeptides in gastrointestinal fluids from humans and rats.
Topics: Amidines; Animals; Drug Stability; Enkephalins; Gastric Juice; Humans; Intestinal Absorption; Jejunum; Leucine; Male; Microvilli; Oligopeptides; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Sulfones; Thiorphan | 1997 |
Enkephalin-processing oligopeptidases in cobra venom: inhibition by thiorphan and bestatin reveals co-operative actions.
Topics: Aminopeptidases; Animals; Drug Synergism; Elapid Venoms; Elapidae; Enkephalins; In Vitro Techniques; Leucine; Peptide Hydrolases; Protease Inhibitors; Substrate Specificity; Thiorphan | 1998 |
Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family.
Topics: Amino Acid Sequence; Animals; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glycopeptides; Glycosylation; Humans; In Situ Hybridization; Inhibitory Concentration 50; Male; Metalloendopeptidases; Mice; Molecular Sequence Data; Neprilysin; Organ Specificity; Protein Processing, Post-Translational; RNA, Messenger; Sequence Alignment; Solubility; Subtilisin; Testis; Thiorphan; Transfection; Zinc | 2000 |
Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Cholera Toxin; Cyclic AMP; Dextrorphan; Enkephalin, Leucine-2-Alanine; Enkephalins; Epithelial Cells; Excitatory Amino Acid Antagonists; Fetus; Intestinal Secretions; Intestines; Kinetics; Levorphanol; Naltrexone; Narcotic Antagonists; Neprilysin; Protease Inhibitors; Rats; Receptors, Opioid, delta; Stereoisomerism; Thiorphan; Tritium | 2000 |
[Role of delta opioid receptors and their ligands in the development of adaptive heart protection against arrhythmogenesis].
Topics: Adaptation, Physiological; Animals; Arrhythmias, Cardiac; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Ligands; Male; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thiorphan | 2001 |
Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Blood Glucose; Brain; C-Peptide; Cell Line; Cell Separation; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Enkephalins; Hemicholinium 3; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Muscarinic Antagonists; Neprilysin; Physostigmine; Rats; Rats, Wistar; Receptors, Muscarinic; Thiorphan | 2010 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |
Neprilysin Controls the Synaptic Activity of Neuropeptides in the Intercalated Cells of the Amygdala.
Topics: Amygdala; Animals; Captopril; Electrical Synapses; Enkephalins; Glutamic Acid; Leucine; Male; Neprilysin; Protease Inhibitors; Proteolysis; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiorphan | 2020 |