thiorphan has been researched along with endothelin-1 in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (53.85) | 18.2507 |
| 2000's | 7 (26.92) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Braquet, P; Lagente, V; Mencia-Huerta, JM; Pons, F; Touvay, C | 1 |
| Opgenorth, TJ; Pollock, DM | 1 |
| Webb, DJ | 1 |
| Balwierczak, JL; Jeng, AY; Kukkola, PJ; Savage, P | 1 |
| Battistini, B; Brown, M; Vane, JR | 1 |
| Eglezos, A; Mattera, GG; Mizrahi, J; Renzetti, AR | 1 |
| Balwierczak, JL; Graybill, SC; Hopkins, MF; Jeng, AY; Lappe, RW; Savage, P; Sperbeck, DM; Stanton, JL; Trapani, AJ | 1 |
| D'Orléans-Juste, P; Fournier, A; Lebel, N; Sirois, P | 1 |
| Ahn, K; Guy, PM; Pan, SM; Sisneros, AM; Zientek, MA | 1 |
| Laporte, J; Sirois, P | 1 |
| Held, HD; Raschak, M; Uhlig, S | 1 |
| Ferro, CJ; Haynes, WG; Spratt, JC; Webb, DJ | 1 |
| Hand, MF; Haynes, WG; Webb, DJ | 1 |
| Dibas, A; Finkley, A; Prasanna, G; Yorio, T | 1 |
| Fujimura, A; Furukawa, K; Inaba, S; Mabuchi, H; Miyamori, I; Takeda, Y | 1 |
| Mayoux, C; Pernet, I; Schmitt, D; Trompezinski, S; Viac, J | 1 |
| Hillier, C; Johnston, F; McMurray, JJ; Petrie, MC | 1 |
| Brandenberger, G; Charloux, A; Doutreleau, S; Geny, B; Hannedouche, T; Piquard, F; Richard, R | 1 |
| D'Orléans-Juste, P; Honoré, JC; Neugebauer, W; Plante, M | 1 |
| Gerbes, AL; Lee, SS; Li, Y; Liu, H; Park, KS; Swain, MG; Zhang, Y | 1 |
| D'Orléans-Juste, P; Fecteau, MH; Honoré, JC; Labonté, J; Plante, M; Rae, GA | 1 |
| Kamata, K; Kobayashi, T; Matsumoto, T; Ozawa, Y; Taguchi, K | 1 |
| D'Orléans-Juste, P; Desbiens, L; Gurish, M; Houde, M; Jamain, MD; Labonté, J; Pejler, G; Takai, S | 1 |
| Batenburg, WW; Bhaggoe, UM; Clahsen-van Groningen, MC; de Vries, R; Domenig, O; Friesema, EC; Garrelds, IM; Hoorn, EJ; Jan Danser, AH; Leijten, FP; Poglitsch, M; Roksnoer, LC; van Veghel, R | 1 |
| de Vries, R; Garrelds, IM; Jan Danser, AH; Roksnoer, LCW; Uijl, E | 1 |
| Badawy, AES; Habib, E; Hasanin, AH; Hussein Mohamed, R; Khairy, E; Mahmoud, D; Mohammed Abdulsalam, T | 1 |
4 trial(s) available for thiorphan and endothelin-1
| Article | Year |
|---|---|
Endogenous endothelin generation maintains vascular tone in humans.
Topics: Adult; Blood Circulation; Endothelin-1; Endothelins; Glycopeptides; Humans; Male; Muscle Tonus; Peptides, Cyclic; Protease Inhibitors; Protein Precursors; Thiorphan; Vascular Resistance; Vasoconstriction; Vasodilation; Vasomotor System | 1995 |
Inhibition of neutral endopeptidase causes vasoconstriction of human resistance vessels in vivo.
Topics: Adult; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Coronary Vessels; Cross-Over Studies; Cyclohexanecarboxylic Acids; Enalapril; Endothelin-1; Humans; Hypertension; Injections, Intra-Arterial; Male; Middle Aged; Myocardium; Neprilysin; Peptides, Cyclic; Protease Inhibitors; Renin; Single-Blind Method; Thiorphan; Vasoconstriction | 1998 |
Reduced endogenous endothelin-1-mediated vascular tone in chronic renal failure.
Topics: Adult; Endothelin Receptor Antagonists; Endothelin-1; Female; Forearm; Glycopeptides; Humans; Injections, Intra-Arterial; Kidney Failure, Chronic; Male; Middle Aged; Norepinephrine; Peptides, Cyclic; Protease Inhibitors; Receptor, Endothelin A; Regional Blood Flow; Thiorphan; Vasomotor System | 1999 |
Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients.
Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclosporine; Double-Blind Method; Endothelin-1; Glomerular Filtration Rate; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Natriuresis; Neprilysin; Protease Inhibitors; Renal Circulation; Thiorphan; Vascular Resistance | 2002 |
22 other study(ies) available for thiorphan and endothelin-1
| Article | Year |
|---|---|
Involvement of a phosphoramidon-sensitive endopeptidase in the processing of big endothelin-1 in the guinea-pig.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bronchi; Chymotrypsin; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Lung; Male; Neprilysin; Pepsin A; Protein Precursors; Sensitivity and Specificity; Thiorphan | 1992 |
Evidence for metalloprotease involvement in the in vivo effects of big endothelin 1.
Topics: Animals; Diuresis; Enalaprilat; Endothelin-1; Endothelins; Glomerular Filtration Rate; Glycopeptides; Hemodynamics; Infusions, Intravenous; Kidney; Male; Metalloendopeptidases; Natriuresis; Potassium; Protein Precursors; Rats; Rats, Inbred Strains; Renal Circulation; Thiorphan | 1991 |
Effects of metalloprotease inhibitors on smooth muscle endothelin-converting enzyme activity.
Topics: Animals; Aspartic Acid Endopeptidases; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Activation; Glycopeptides; Metalloendopeptidases; Methionine; Muscle, Smooth, Vascular; Propionates; Protein Precursors; Structure-Activity Relationship; Swine; Thiorphan | 1995 |
Selective proteolitic activation and degradation of ETs and big ETs in parenchymal strips of the guinea-pig lung.
Topics: Animals; Captopril; Endopeptidases; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Humans; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Protein Precursors; Structure-Activity Relationship; Swine; Thiorphan | 1995 |
Comparison of the cardiovascular and neural activity of endothelin-1, -2, -3 and respective proendothelins: effects of phosphoramidon and thiorphan.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Endothelin-3; Endothelins; Ganglionic Blockers; Glycopeptides; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; Thiorphan; Vas Deferens | 1993 |
Effects of metalloprotease inhibitors on the conversion of proendothelin-1 to endothelin-1.
Topics: Animals; Aspartic Acid Endopeptidases; Benzazepines; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Endothelium, Vascular; Glycopeptides; In Vitro Techniques; Male; Metalloendopeptidases; Methionine; Muscle Contraction; Muscle, Smooth, Vascular; Neprilysin; Propionates; Protein Precursors; Rats; Rats, Sprague-Dawley; Swine; Thiorphan | 1993 |
Role of the neutral endopeptidase 24.11 in the conversion of big endothelins in guinea-pig lung parenchyma.
Topics: Alanine; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Endothelin-1; Endothelins; Glycopeptides; Guinea Pigs; Histamine; In Vitro Techniques; Lung; Neprilysin; Protease Inhibitors; Protein Precursors; Thiorphan | 1996 |
Characterization of endothelin converting enzyme from intact cells of a permanent human endothelial cell line, EA.hy926.
Topics: Aspartic Acid Endopeptidases; Cells, Cultured; Endometrium; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Female; Glycopeptides; Humans; Metalloendopeptidases; Protein Precursors; Radioimmunoassay; Thiorphan | 1996 |
Phosphoramidon and thiorphan suppress the generation of endothelin (ET) from exogenous big-endothelin by guinea pig Clara cells.
Topics: Animals; Bronchi; Cells, Cultured; Endothelin-1; Endothelins; Epithelial Cells; Epithelium; Glycopeptides; Guinea Pigs; Metalloendopeptidases; Protease Inhibitors; Protein Precursors; Radioimmunoassay; Thiorphan | 1997 |
Rat big endothelin-1-induced bronchoconstriction and vasoconstriction in the isolated perfused rat lung: role of endothelin converting enzyme and neutral endopeptidase 24.11.
Topics: Airway Resistance; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Bronchoconstriction; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Female; Glycopeptides; Lung; Metalloendopeptidases; Neprilysin; Organophosphonates; Perfusion; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Tetrazoles; Thiorphan; Vascular Resistance; Vasoconstriction | 1997 |
Identification of endothelin converting enzyme-1 in human non-pigmented ciliary epithelial cells.
Topics: Aspartic Acid Endopeptidases; Blotting, Western; Cells, Cultured; Ciliary Body; Endothelin-1; Endothelin-Converting Enzymes; Epithelial Cells; Humans; Immunoenzyme Techniques; Metalloendopeptidases; Thiorphan | 1999 |
Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension.
Topics: Animals; Blood Pressure; Blotting, Southern; Cyclosporine; DNA Probes; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Natriuretic Peptide, C-Type; Neprilysin; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Protease Inhibitors; Rats; Rats, Inbred WKY; RNA, Messenger; Thiorphan | 2000 |
Modulation of endothelin-1 in normal human keratinocytes by UVA1/B radiations, prostaglandin E2 and peptidase inhibitors.
Topics: Cells, Cultured; Dinoprostone; Endothelin-1; Endothelins; Gene Expression Regulation; Glycopeptides; Humans; Infant, Newborn; Keratinocytes; Male; Polymerase Chain Reaction; Protease Inhibitors; Protein Precursors; Skin; Thiorphan; Transcription, Genetic; Ultraviolet Rays | 2000 |
Effect of neutral endopeptidase inhibition on the actions of adrenomedullin and endothelin-1 in resistance arteries from patients with chronic heart failure.
Topics: Adrenomedullin; Antihypertensive Agents; Arteries; Chronic Disease; Dose-Response Relationship, Drug; Endothelin-1; Female; Heart Failure; Humans; In Vitro Techniques; Male; Peptides; Protease Inhibitors; Thiorphan; Vascular Resistance; Vasoconstriction | 2001 |
Endothelin-1 (1-31) induces a thiorphan-sensitive release of eicosanoids via ET(B) receptors in the guinea pig perfused lung.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Eicosanoids; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Enzyme Inhibitors; Guinea Pigs; Lung; Neprilysin; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Perfusion; Piperidines; Protein Precursors; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Thiorphan; Thromboxane A2 | 2002 |
Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats.
Topics: Animals; Atrial Natriuretic Factor; Cardiovascular Physiological Phenomena; Cyclic GMP; Endothelin-1; Glomerular Filtration Rate; Hemodynamics; Kidney; Liver Cirrhosis, Experimental; Natriuresis; Neprilysin; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium; Sodium-Potassium-Exchanging ATPase; Thiorphan | 2003 |
Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Female; Glycopeptides; Heart Ventricles; Injections; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Peptide Fragments; Protease Inhibitors; Rabbits; Receptors, Endothelin; Thiorphan | 2005 |
Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Glucose; Body Weight; Coronary Vessels; Diabetes Mellitus, Experimental; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; Glycopeptides; Heart; Lipids; Lysine; Male; Metalloendopeptidases; Myocardium; Oligopeptides; Organ Size; Organophosphonates; Peptides, Cyclic; Perfusion; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Thiorphan; Vasoconstriction | 2010 |
Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.
Topics: Animals; Aorta; Carboxypeptidases A; Drug Resistance; Endothelin-1; Gene Expression Regulation, Enzymologic; Heart Ventricles; Hemodynamics; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Peptide Fragments; Protein Processing, Post-Translational; Proteolysis; RNA, Messenger; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfonamides; Thiophenes; Thiorphan | 2013 |
Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterial Pressure; Atrial Natriuretic Factor; Biphenyl Compounds; Body Weight; Endothelin B Receptor Antagonists; Endothelin-1; Irbesartan; Kidney; Myocardium; Myocytes, Cardiac; Neprilysin; Oligopeptides; Organ Size; Piperidines; Protease Inhibitors; Rats; Receptor, Angiotensin, Type 1; Receptor, Endothelin B; Renin-Angiotensin System; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Tetrazoles; Thiorphan; Up-Regulation; Vasoconstriction; Vasodilation | 2015 |
Neprilysin inhibition and endothelin-1 elevation: Focus on the kidney.
Topics: Aminobutyrates; Animals; Biphenyl Compounds; Drug Combinations; Endothelin-1; Kidney; Neprilysin; Protease Inhibitors; Rats; Tetrazoles; Thiorphan; Valsartan | 2018 |
Angiotensin receptor-neprilysin inhibitor (thiorphan/irbesartan) improved cardiac function in a rat model of myocardial ischemic reperfusion injury.
Topics: Animals; Cardiotonic Agents; Endothelin-1; Irbesartan; Male; Myocardial Reperfusion Injury; Myocardium; Neprilysin; Rats; Rats, Wistar; Receptors, Angiotensin; Thiorphan | 2023 |