thiorphan and atrial natriuretic factor

thiorphan has been researched along with atrial natriuretic factor in 64 studies

Research

Studies (64)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (12.50)	18.7374
1990's	45 (70.31)	18.2507
2000's	10 (15.63)	29.6817
2010's	1 (1.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Corvol, P; el Amrani, AI; Fournié-Zaluski, MC; Michel, JB; Pham, I; Roques, B	1
Beaumont, A; Ficheux, D; Fournié-Zaluski, MC; Lucas, E; Michel, JB; Roques, BP; Soleilhac, JM; Turcaud, S	1
Casley, DJ; Haslanger, MF; Johnston, CI; Kanazawa, M; Sybertz, EJ	1
Hayakawa, H; Hirata, Y; Kangawa, K; Kojima, M; Matsuo, H; Matsuoka, H; Sugimoto, T; Suzuki, E	1
Bralet, J; Gros, C; Mossiat, C; Schwartz, JC	1
Duboc, D; Fouchard, J; Guérin, F; Muffat-Joly, M; Schwartz, JC; Varin, J; Weber, S	1
Chiyotani, A; Horii, S; Isono, K; Kanemura, T; Kobayashi, K; Sakai, N; Takeuchi, S; Takizawa, T; Tamaoki, J; Yamawaki, I	1
Hayakawa, H; Hirata, Y; Kangawa, K; Matsuo, H; Matsuoka, H; Sugimoto, T; Suzuki, E	1
Chiu, PJ; Sybertz, EJ; Vemulapalli, S; Watkins, RW	1
Advenier, C; Candenas, ML; Devillier, P; Naline, E; Puybasset, L	1
Ardaillou, R; Bodin, F; Dussaule, JC; Grangé, JD; Gros, C; Lecomte, JM; Schwartz, JC; Wolf, JP	1
Hirata, Y	1
Bralet, J; Danvy, D; Duhamel, L; Duhamel, P; Gros, C; Lecomte, JM; Noël, N; Plaquevent, JC; Schwartz, JC; Souque, A	1
Castaigne, A; Duboc, D; Dubois-Rande, JL; Gros, C; Kahn, JC; Lecomte, JM; Lim-Alexandre, C; Merlet, P; Patey, M; Schwartz, JC	1
Barclay, PL; Danilewicz, JC; Samuels, GM	1
McGraw, DE; Smits, GJ; Trapani, AJ	1
Gros, C; Schwartz, JC; Souque, A	2
Bralet, J; Charpentier, S; Gros, C; Lecomte, JM; Mossiat, C; Schwartz, JC	1
Blaine, EB; McGraw, DE; Smits, GJ; Trapani, AJ	1
Blaine, EH; Blehm, DJ; Koepke, JP; Schuh, JR; Tyler, LD	1
Ardaillou, R; Baumer, P; Chaignon, B; Cournot, A; Duchier, J; Dussaule, JC; Gros, C; Lecomte, JM; Lim, C; Souque, A	1
Needleman, P; Settle, SL; Stockmann, PT; Wilkins, MR	1
Blaine, EH; Bovy, PR; Hartupee, DA; Koepke, JP; Mehta, PP; Olins, GM; Spear, KL; Trapani, AJ; Tyler, LD	1
McMartin, C; McNeal, RB; Webb, RL; Yasay, GD; Zimmerman, MB	1
Blaine, EH; Koepke, JP; McGraw, DE; Olins, GM; Smits, GJ; Spear, KL; Trapani, AJ	1
Bovy, PR; Krieter, PA; Olins, GM; Spear, KL; Trapani, AJ	1
Durley, RC; Krieter, PA; Olins, GM; Verrett, SP	1
Baumer, P; Cournot, A; Duchier, J; Gros, C; Lecomte, JM; Schwartz, JC; Souque, A	1
Charles, D; Erion, MD; Gilligan, JP; Koehn, JA; McMartin, C; Miller, MJ; Palmesino, RA; Sharif, R; Tamburini, PP	1
Anderson, S; Brenner, BM; Gunning, M; Lafferty, HM; Silva, P; Zimmerman, MB	1
Blaine, EH; Bovy, PR; Koepke, JP; Olins, GM; Spear, KL; Trapani, AJ; Tyler, LD	1
Beil, ME; Coté, DT; de Lombaert, S; Erion, MD; Gerlock, TE; Ghai, RD; Hopkins, MF; Peppard, JV; Trapani, AJ; Webb, RL	1
Dressel, J; Hirth-Dietrich, C; Kazda, S; Stasch, JP; Voges, KP; Wegner, M	1
Hirth-Dietrich, C; Knorr, A; Stasch, JP; Wegner, M	1
Brouard, R; Brunner, HR; Burnier, M; Favrat, B; Lecomte, JM; Nussberger, J; Waeber, B	1
Berry, C; De Lombaert, S; Ghai, RD; Ksander, GM; Sakane, Y; Trapani, AJ	1
Angus, RM; Chalmers, GW; Millar, EA; Thomson, NC	2
De Prez, E; Deschodt-Lanckman, M; Nortier, J; Pauwels, S	1
Cernacek, P; Mulay, S; Omer, S; Varma, DR	1
Goto, A; Hayakawa, H; Hirata, Y; Kangawa, K; Kimura, K; Matsuo, H; Minamino, N; Omata, M; Suzuki, E; Suzuki, Y	1
Ardaillou, R; Dussaule, JC; Gros, C; Lecomte, JM; Michel, C; Mignon, F; Peraldi, MN	1
Berry, CJ; Fink, CA; Ghai, RD; Qiao, Y; Sakane, Y; Trapani, AJ	1
Beslot, F; Claperon, N; Fournie-Zaluski, MC; Peyroux, J; Roques, BP	1
Hirth-Dietrich, C; Stasch, JP; Wegner, M	1
Tucker, VL	1
Ganten, D; Stasch, JP; Wegner, M	1
Bohacek, R; de Jesus, R; Ghai, RD; Ksander, GM; McMartin, C; Trapani, A; Yuan, A	1
Morazzoni, G; Norcini, G; Pocchiari, F; Santangelo, F; Semeraro, C	1
Hayashi, I; Ito, H; Katori, M; Majima, M; Nakajima, S; Yajima, Y	1
Ferro, CJ; Haynes, WG; Spratt, JC; Webb, DJ	1
Hashimoto, Y; Inui, K; Itoh, H; Nakao, K; Ozaki, J; Shimizu, H	1
Bryant, HJ; Chen, S; Ghai, RD; Haddy, FJ; Pamnani, MB; Schooley, JF	1
Goetze, L; Sisson, D; Solter, P; Thomas, W	1
Capasso, G; Ciani, F; De Santo, NG; Pica, A; Rizzo, A; Russo, F; Unwin, R	1
Brandenberger, G; Charloux, A; Doutreleau, S; Geny, B; Hannedouche, T; Piquard, F; Richard, R	1
Houard, X; Jacob, MP; Meilhac, O; Michel, JB; Mtairag, el M; Oudghiri, M; Pasquier, C; Rais, S	1
Gerbes, AL; Lee, SS; Li, Y; Liu, H; Park, KS; Swain, MG; Zhang, Y	1
Cruden, NL; Fox, KA; Johnston, NR; Ludlam, CA; Newby, DE	1
Berlan, M; Galitzky, J; Klimcakova, E; Lafontan, M; Moro, C	1
Honda, J; Kimura, NY; Maeshiro, K; Matsuo, T; Mifune, H; Shirouzu, K; Takamori, S	1
Baliga, RS; Hobbs, AJ; Lopez-Torondel, B; MacAllister, RJ; Madhani, M; Selwood, D; Visintin, C; Wilkins, MR; Zhao, L	1
Batenburg, WW; Bhaggoe, UM; Clahsen-van Groningen, MC; de Vries, R; Domenig, O; Friesema, EC; Garrelds, IM; Hoorn, EJ; Jan Danser, AH; Leijten, FP; Poglitsch, M; Roksnoer, LC; van Veghel, R	1

Reviews

1 review(s) available for thiorphan and atrial natriuretic factor

Article	Year
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency]. Archives des maladies du coeur et des vaisseaux, 1991, Volume: 84, Issue:10 Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Cyclic GMP; Diuresis; Female; Heart Failure; Humans; Male; Middle Aged; Natriuresis; Neprilysin; Thiorphan	1991

Trials

12 trial(s) available for thiorphan and atrial natriuretic factor

Article	Year
[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency]. Archives des maladies du coeur et des vaisseaux, 1991, Volume: 84, Issue:10 Topics: Adult; Aged; Atrial Natriuretic Factor; Blood Pressure; Creatinine; Cyclic GMP; Diuresis; Female; Heart Failure; Humans; Male; Middle Aged; Natriuresis; Neprilysin; Thiorphan	1991
Effect of sinorphan, an enkephalinase inhibitor, on plasma atrial natriuretic factor and sodium urinary excretion in cirrhotic patients with ascites. The Journal of clinical endocrinology and metabolism, 1991, Volume: 72, Issue:3 Topics: Administration, Oral; Adult; Aldosterone; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Liver Cirrhosis; Male; Middle Aged; Neprilysin; Renin; Sodium; Thiorphan	1991
Effect of sinorphan on plasma atrial natriuretic factor in congestive heart failure. Lancet (London, England), 1990, Jan-13, Volume: 335, Issue:8681 Topics: Administration, Oral; Atrial Natriuretic Factor; Clinical Trials as Topic; Drug Administration Schedule; Heart Failure; Humans; Male; Neprilysin; Stimulation, Chemical; Thiorphan	1990
Stereoselective protection of exogenous and endogenous atrial natriuretic factor by enkephalinase inhibitors in mice and humans. European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2 Topics: Administration, Oral; Adult; Animals; Atrial Natriuretic Factor; Binding, Competitive; Chemical Phenomena; Chemistry; Cyclic GMP; Double-Blind Method; Humans; Injections, Intravenous; Kidney; Male; Mice; Neprilysin; Random Allocation; Thiorphan; Time Factors	1990
Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC 3.4.24.11) by acetorphan. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:19 Topics: Animals; Atrial Natriuretic Factor; Diuresis; Humans; Hydrolysis; Kidney; Kinetics; Male; Mice; Natriuresis; Neprilysin; Thiorphan	1989
Neutral endopeptidase versus angiotensin converting enzyme inhibition in essential hypertension. Journal of hypertension, 1995, Volume: 13, Issue:7 Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Captopril; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Neprilysin; Protease Inhibitors; Thiorphan	1995
Effect of inhaled atrial natriuretic peptide and a neutral endopeptidase inhibitor on histamine-induced bronchoconstriction. American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:6 Topics: Administration, Inhalation; Adult; Asthma; Atrial Natriuretic Factor; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Neprilysin; Thiorphan	1995
Inhibition of neutral endopeptidase stimulates renal sodium excretion in patients with chronic renal failure. Clinical science (London, England : 1979), 1993, Volume: 84, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Atrial Natriuretic Factor; Cyclic GMP; Double-Blind Method; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Neprilysin; Sodium; Sodium, Dietary; Thiorphan; Time Factors	1993
Effect of inhaled thiorphan, a neutral endopeptidase inhibitor, on the bronchodilator response to inhaled atrial natriuretic peptide (ANP). Thorax, 1996, Volume: 51, Issue:1 Topics: Administration, Inhalation; Adult; Albuterol; Asthma; Atrial Natriuretic Factor; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Synergism; Female; Forced Expiratory Volume; Humans; Lung; Male; Middle Aged; Protease Inhibitors; Thiorphan	1996
Inhibition of neutral endopeptidase causes vasoconstriction of human resistance vessels in vivo. Circulation, 1998, Jun-16, Volume: 97, Issue:23 Topics: Adult; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Blood Pressure; Coronary Vessels; Cross-Over Studies; Cyclohexanecarboxylic Acids; Enalapril; Endothelin-1; Humans; Hypertension; Injections, Intra-Arterial; Male; Middle Aged; Myocardium; Neprilysin; Peptides, Cyclic; Protease Inhibitors; Renin; Single-Blind Method; Thiorphan; Vasoconstriction	1998
Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:2 Topics: Adult; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Cyclosporine; Double-Blind Method; Endothelin-1; Glomerular Filtration Rate; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Natriuresis; Neprilysin; Protease Inhibitors; Renal Circulation; Thiorphan; Vascular Resistance	2002
Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 44, Issue:6 Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor; Bradykinin; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Heart Failure; Humans; Male; Middle Aged; Neprilysin; Nitroprusside; Protease Inhibitors; Receptor, Bradykinin B1; Thiorphan; Tissue Plasminogen Activator; Vasodilation; Vasodilator Agents	2004

Other Studies

52 other study(ies) available for thiorphan and atrial natriuretic factor

Article	Year
Effects of the selective neutral endopeptidase inhibitor, retrothiorphan, on renal function and blood pressure in conscious normotensive Wistar and hypertensive DOCA-salt rats. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Bradykinin; Cyclic GMP; Desoxycorticosterone; Diuresis; Hypertension; Kidney; Kininogens; Male; Natriuresis; Neprilysin; Rats; Rats, Wistar; Sulfhydryl Compounds; Thiorphan	1992
A 94-kDa protein, identified as neutral endopeptidase-24.11, can inactivate atrial natriuretic peptide in the vascular endothelium. Molecular pharmacology, 1992, Volume: 41, Issue:4 Topics: Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Autoradiography; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enkephalin, Leucine-2-Alanine; Humans; In Vitro Techniques; Molecular Sequence Data; Neprilysin; Rats; Sulfhydryl Compounds; Thiorphan	1992
Localization and characterization of neutral metalloendopeptidase (EC 3.4.24.11), the degradative enzyme for atrial natriuretic peptide, in rat kidney using a radioiodinated neutral metalloendopeptidase inhibitor. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3 Topics: Animals; Atrial Natriuretic Factor; Autoradiography; Binding, Competitive; Cell Membrane; Dipeptides; Drug Interactions; Glycopeptides; Iodine Radioisotopes; Kidney; Male; Neprilysin; Phenols; Phenylalanine; Rats; Rats, Inbred Strains; Thiorphan	1992
Role of endogenous ANP in sodium excretion in rats with experimental pulmonary hypertension. The American journal of physiology, 1992, Volume: 262, Issue:6 Pt 2 Topics: Animals; Atrial Natriuretic Factor; Hypertension, Pulmonary; Immune Sera; Male; Monocrotaline; Natriuresis; Rats; Rats, Inbred Strains; Thiorphan	1992
Thiorphan-induced natriuresis in volume-expanded rats: roles of endogenous atrial natriuretic factor and kinins. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:3 Topics: Animals; Antibodies; Atrial Function; Atrial Natriuretic Factor; Bradykinin; Cardiac Volume; Cyclic GMP; Kidney; Kinins; Male; Natriuresis; Neprilysin; Rats; Rats, Inbred Strains; Thiorphan	1991
Atrial natriuretic factor inhibits ciliary motility in cultured rabbit tracheal epithelium. The American journal of physiology, 1991, Volume: 260, Issue:2 Pt 1 Topics: Animals; Atrial Natriuretic Factor; Captopril; Cells, Cultured; Cilia; Enzyme Inhibitors; Epithelium; Glycopeptides; Indomethacin; Kinetics; Leucine; Leupeptins; Male; Masoprocol; Methylene Blue; Movement; Piroxicam; Purinones; Rabbits; Thiorphan; Trachea	1991
Role of endogenous atrial natriuretic peptide in regulating sodium excretion in spontaneously hypertensive rats. Effects of neutral endopeptidase inhibition. Hypertension (Dallas, Tex. : 1979), 1991, Volume: 17, Issue:6 Pt 2 Topics: Animals; Atrial Natriuretic Factor; Bradykinin; Immune Sera; Male; Natriuresis; Neprilysin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thiorphan	1991
Neutral metalloendopeptidase inhibitors as ANF potentiators: sites and mechanisms of action. Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:10 Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Bradykinin; Desoxycorticosterone; Dioxolanes; Dipeptides; Drug Synergism; Hypertension; Iodine Radioisotopes; Kinins; Male; Metalloendopeptidases; Rats; Rats, Inbred Strains; Thiorphan	1991
Effect of atrial natriuretic peptide and on atriopeptins on the human isolated bronchus. Comparison with the reactivity of the guinea-pig isolated trachea. Pulmonary pharmacology, 1991, Volume: 4, Issue:2 Topics: Amino Acid Sequence; Animals; Atrial Natriuretic Factor; Bronchi; Drug Synergism; Epithelium; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Male; Molecular Sequence Data; Muscle Contraction; Muscle Relaxation; Peptide Fragments; Thiorphan; Trachea	1991
[Clinical significance and therapeutic application of atrial natriuretic peptides]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1991, Jan-10, Volume: 80, Issue:1 Topics: Animals; Atrial Natriuretic Factor; Glycopeptides; Heart Atria; Heart Failure; Hemodynamics; Humans; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Thiorphan	1991
Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril. Proceedings of the National Academy of Sciences of the United States of America, 1991, May-15, Volume: 88, Issue:10 Topics: Alanine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Cell Membrane; Cyclic GMP; Dioxoles; Dipeptides; Diuresis; Glycine; Humans; Lung; Male; Mice; Molecular Structure; Natriuresis; Neprilysin; Peptidyl-Dipeptidase A; Rats; Rats, Inbred Strains; Thiorphan	1991
Inhibitory potencies of UK-69 578 and thiorphan. Lancet (London, England), 1990, Sep-22, Volume: 336, Issue:8717 Topics: Atrial Natriuretic Factor; Carbamates; Cyclohexanecarboxylic Acids; Depression, Chemical; Propionates; Substrate Specificity; Thiorphan	1990
Interaction of ANP and bradykinin during endopeptidase 24.11 inhibition: renal effects. The American journal of physiology, 1990, Volume: 258, Issue:5 Pt 2 Topics: Animals; Atrial Natriuretic Factor; Bradykinin; Captopril; Diuretics; Drug Synergism; Kidney; Male; Natriuresis; Neprilysin; Peptide Fragments; Rats; Rats, Inbred Strains; Thiorphan	1990
Inactivation of atrial natriuretic factor in mice in vivo: crucial role of enkephalinase (EC 3.4.24.11). European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2 Topics: Administration, Oral; Animals; Atrial Natriuretic Factor; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Iodine Radioisotopes; Kidney; Male; Mice; Neprilysin; Protease Inhibitors; Thiorphan; Time Factors	1990
Diuretic and natriuretic responses in rats treated with enkephalinase inhibitors. European journal of pharmacology, 1990, Apr-10, Volume: 179, Issue:1-2 Topics: Animals; Atrial Natriuretic Factor; Chromatography, High Pressure Liquid; Diuresis; Injections, Intravenous; Male; Natriuresis; Neprilysin; Potassium; Prodrugs; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Thiorphan; Time Factors	1990
Effect of endopeptidase 24.11 inhibition in conscious cardiomyopathic hamsters. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: Animals; Atrial Natriuretic Factor; Cardiomyopathies; Cricetinae; Heart Failure; Male; Neprilysin; Sodium; Thiorphan	1990
Chronic atriopeptin regulation of arterial pressure in conscious hypertensive rats. Hypertension (Dallas, Tex. : 1979), 1990, Volume: 16, Issue:6 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Male; Peptide Fragments; Rats; Rats, Inbred SHR; Thiorphan; Time Factors	1990
Degradation of atrial natriuretic factor in mouse blood in vitro and in vivo: role of enkephalinase (EC 3.4.24.11). Neuropeptides, 1990, Volume: 17, Issue:1 Topics: Animals; Atrial Natriuretic Factor; Chromatography, High Pressure Liquid; Half-Life; Hydrolysis; In Vitro Techniques; Iodine Radioisotopes; Male; Metabolic Clearance Rate; Mice; Neprilysin; Thiorphan	1990
Maximizing the natriuretic effect of endogenous atriopeptin in a rat model of heart failure. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:16 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antibodies, Monoclonal; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Disease Models, Animal; Heart Failure; Male; Purinones; Rats; Rats, Inbred Strains; Reference Values; Sodium; Thiorphan	1990
Atriopeptin regulation and renal function in conscious spontaneously hypertensive rats. American journal of hypertension, 1990, Volume: 3, Issue:8 Pt 1 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Drug Interactions; Guanosine Monophosphate; Male; Natriuresis; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thiorphan; Time Factors	1990
Degradation of atrial natriuretic peptide: pharmacologic effects of protease EC 24.11 inhibition. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Glycopeptides; Heart Rate; In Vitro Techniques; Kidney; Male; Protease Inhibitors; Rats; Rats, Inbred SHR; Sodium; Thiorphan; Time Factors	1989
Thiorphan, an inhibitor of endopeptidase 24.11, potentiates the natriuretic activity of atrial natriuretic peptide. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:3 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Drug Synergism; Hemodynamics; Iodine Radioisotopes; Kidney; Male; Natriuresis; Neprilysin; Peptide Fragments; Rats; Rats, Inbred Strains; Sodium; Thiorphan	1989
Specific inhibitors of endopeptidase 24.11 inhibit the metabolism of atrial natriuretic peptides in vitro and in vivo. Molecular and cellular endocrinology, 1989, Volume: 61, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Dipeptides; Kidney; Male; Microvilli; Neprilysin; Protease Inhibitors; Rabbits; Rats; Thiorphan	1989
In vivo metabolism of atrial natriuretic peptide: identification of plasma metabolites and enzymes responsible for their generation. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Carboxypeptidases; Endopeptidases; Kidney; Phenylalanine; Rats; Thiorphan; Tyrosine	1989
Rat vascular tissue contains a neutral endopeptidase capable of degrading atrial natriuretic peptide. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:3 Topics: Animals; Atrial Natriuretic Factor; Blood Vessels; Endopeptidases; Female; Hydrogen-Ion Concentration; Hydrolysis; Male; Rabbits; Rats; Rats, Inbred Strains; Thiorphan	1989
Enkephalinase inhibition increases plasma atrial natriuretic peptide levels, glomerular filtration rate, and urinary sodium excretion in rats with reduced renal mass. Circulation research, 1989, Volume: 65, Issue:3 Topics: Animals; Anti-Bacterial Agents; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Glomerular Filtration Rate; Glycopeptides; Kidney; Male; Nephrectomy; Neprilysin; Rats; Rats, Inbred Strains; Reference Values; Sodium; Thiorphan	1989
Interaction of non-guanylate cyclase-linked atriopeptin receptor ligand and endopeptidase inhibitor in conscious rats. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:1 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Diuresis; Guanylate Cyclase; Male; Natriuresis; Peptide Fragments; Protease Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Structure-Activity Relationship; Thiorphan	1989
Pharmacologic profile of CGS 24128, a potent, long-acting inhibitor of neutral endopeptidase 24.11. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:3 Topics: Amino Acid Sequence; Animals; Atrial Natriuretic Factor; beta-Alanine; Blood Pressure; Desoxycorticosterone; Diuresis; Heart Rate; Hypertension; Kidney; Male; Molecular Sequence Data; Natriuresis; Neprilysin; Organophosphonates; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiorphan	1994
Interaction of a neutral endopeptidase inhibitor with an ANP-C receptor ligand in anesthetized dogs. Clinical and experimental hypertension (New York, N.Y. : 1993), 1995, Volume: 17, Issue:6 Topics: Animals; Atrial Natriuretic Factor; Cardiovascular Diseases; Cyclic GMP; Diuresis; Dogs; Drug Interactions; Female; Kidney; Ligands; Natriuresis; Neprilysin; Oligopeptides; Protease Inhibitors; Receptors, Atrial Natriuretic Factor; Renin; Thiorphan	1995
Prolonged inhibition of neutral endopeptidase 24.11 by sinorphan in stroke-prone spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension, 1995, Volume: 18, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Heart Failure; Hemodynamics; Kidney Function Tests; Neprilysin; Rats; Rats, Inbred SHR; Sodium, Dietary; Thiorphan; Time Factors	1995
A rapid indirect method to determine the plasma concentrations of neutral endopeptidase inhibitors. Research communications in molecular pathology and pharmacology, 1995, Volume: 87, Issue:2 Topics: Animals; Atrial Natriuretic Factor; beta-Alanine; Cyclohexanecarboxylic Acids; Enzyme Inhibitors; Kidney Cortex; Male; Methods; Neprilysin; Organophosphonates; Rats; Rats, Sprague-Dawley; Thiorphan	1995
Human neutrophil and plasma endopeptidase 24.11: quantification and respective roles in atrial natriuretic peptide hydrolysis. European journal of clinical investigation, 1995, Volume: 25, Issue:3 Topics: Amino Acid Sequence; Atrial Natriuretic Factor; Humans; Hydrolysis; Molecular Sequence Data; Neprilysin; Neutrophils; Oligopeptides; Peptide Fragments; Reference Values; Substrate Specificity; Thiorphan	1995
Attenuation of renal effects of atrial natriuretic factor during rat pregnancy. The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 2 Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Diuresis; Female; Glomerular Filtration Rate; Kidney; Natriuresis; Peptide Fragments; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Thiorphan	1995
Mechanisms underlying the augmented responses of deoxycorticosterone acetate-salt hypertensive rats to neutral endopeptidase inhibitors. Journal of hypertension, 1994, Volume: 12, Issue:4 Topics: Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Base Sequence; Blood Pressure; Desoxycorticosterone; Hypertension; Indans; Male; Molecular Sequence Data; Neprilysin; Polysaccharides; Propionates; Rats; Rats, Wistar; Sodium Chloride; Thiorphan	1994
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11. Journal of medicinal chemistry, 1995, Dec-22, Volume: 38, Issue:26 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Blood Pressure; Captopril; Dipeptides; Magnetic Resonance Spectroscopy; Male; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfhydryl Compounds; Thiorphan; Tryptophan	1995
Effect of endopeptidase-24.11 inhibitors and C-ANP receptor ligand on responses evoked in arterioles of rat cremaster muscle by atrial natriuretic peptide. British journal of pharmacology, 1995, Volume: 116, Issue:8 Topics: Abdominal Muscles; Adenosine; Administration, Topical; Animals; Arterioles; Atrial Natriuretic Factor; Blood Pressure; Dipeptides; Injections, Intravenous; Male; Neprilysin; Nitroprusside; Peptide Fragments; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Thiorphan; Vasodilator Agents	1995
Role of neutral endopeptidase 24.11 in AV fistular rat model of heart failure. Cardiovascular research, 1996, Volume: 31, Issue:6 Topics: Angiotensin I; Animals; Aorta; Arteriovenous Fistula; Atrial Natriuretic Factor; Disease Models, Animal; Heart Failure; Natriuretic Peptide, Brain; Neprilysin; Nerve Tissue Proteins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Renin; Sodium; Thiorphan; Venae Cavae	1996
Contribution of ANP to plasma protein escape during VE: effects of thiorphan and atrial appendectomy. The American journal of physiology, 1996, Volume: 271, Issue:3 Pt 2 Topics: Animals; Appendectomy; Atrial Natriuretic Factor; Biological Transport; Blood Pressure; Blood Proteins; Body Fluids; Male; Plasma Substitutes; Rats; Rats, Wistar; Serum Albumin, Bovine; Thiorphan; Tissue Distribution	1996
Neutral endopeptidase inhibition potentiates the effects of natriuretic peptides in renin transgenic rats. Hypertension research : official journal of the Japanese Society of Hypertension, 1996, Volume: 19, Issue:4 Topics: Animals; Animals, Genetically Modified; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Disease Models, Animal; Drug Therapy, Combination; Electrolytes; Hypertension; Mice; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Neprilysin; Protease Inhibitors; Proteins; Rats; Rats, Sprague-Dawley; Renin; Sodium; Thiorphan	1996
Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors. Journal of medicinal chemistry, 1997, Feb-14, Volume: 40, Issue:4 Topics: Animals; Atrial Natriuretic Factor; Binding Sites; Drug Synergism; Lactams; Models, Chemical; Models, Molecular; Neprilysin; Rats; Software; Thiorphan	1997
Novel selective thiol inhibitors of neutral endopeptidase containing heterocycles at P'2 position. Journal of enzyme inhibition, 1997, Volume: 12, Issue:2 Topics: Atrial Natriuretic Factor; Models, Chemical; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Structure-Activity Relationship; Thiorphan	1997
Effects of a neutral endopeptidase inhibitor, BP102, on the development of deoxycorticosterone acetate-salt hypertension in kininogen-deficient Brown Norway Katholiek rats. International journal of tissue reactions, 1998, Volume: 20, Issue:2 Topics: Administration, Oral; Animals; Atrial Natriuretic Factor; Desoxycorticosterone; Drug Administration Schedule; Enzyme Inhibitors; Heart; Hypertension; Kidney; Kininogens; Kinins; Male; Neprilysin; Organ Size; Prodrugs; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Sodium Chloride; Thiorphan; Time Factors	1998
Enzymatic inactivation of major circulating forms of atrial and brain natriuretic peptides. European journal of pharmacology, 1999, Apr-16, Volume: 370, Issue:3 Topics: Animals; Atrial Natriuretic Factor; Cell Culture Techniques; Cyclic GMP; Glycopeptides; Humans; LLC-PK1 Cells; Male; Natriuresis; Neprilysin; Nitrobenzenes; Protease Inhibitors; Rats; Rats, Wistar; Swine; Thiorphan	1999
Effects of a neutral endoprotease enzyme inhibitor, thiorphan, on hemodynamics and renal excretory function in four models of experimental hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993), 2000, Volume: 22, Issue:1 Topics: Animals; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cyclic GMP; Hypertension; Infusions, Intravenous; Kidney; Male; Potassium; Protease Inhibitors; Rats; Rats, Inbred SHR; Sodium; Thiorphan; Urodynamics	2000
Intrarenal effects of ecadotril during acute volume expansion in dogs with congestive heart failure. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:3 Topics: Animals; Atrial Natriuretic Factor; Dogs; Glomerular Filtration Rate; Heart Failure; Kidney; Male; Neprilysin; Protease Inhibitors; Renal Circulation; Thiorphan	2000
Inhibition of neutral endopeptidase potentiates the effects of atrial natriuretic peptide on acute cyclosporin-induced nephrotoxicity. Nephron, 2000, Volume: 86, Issue:3 Topics: Acute Disease; Animals; Atrial Natriuretic Factor; Cyclosporine; Drug Synergism; Glomerular Filtration Rate; Immunosuppressive Agents; Injections, Intravenous; Inulin; Kidney; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Wistar; Sodium Chloride; Thiorphan; Tritium	2000
Pharmacological potentiation of natriuretic peptide limits polymorphonuclear neutrophil-vascular cell interactions. Arteriosclerosis, thrombosis, and vascular biology, 2002, Nov-01, Volume: 22, Issue:11 Topics: Atrial Natriuretic Factor; Cell Adhesion; Cell Communication; Cell Degranulation; Culture Media, Conditioned; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Fibronectins; Humans; Hypoxia; Leukocyte Elastase; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Neprilysin; Neutrophil Activation; Neutrophils; Respiratory Burst; Thiorphan; Umbilical Veins	2002
Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats. British journal of pharmacology, 2003, Volume: 139, Issue:1 Topics: Animals; Atrial Natriuretic Factor; Cardiovascular Physiological Phenomena; Cyclic GMP; Endothelin-1; Glomerular Filtration Rate; Hemodynamics; Kidney; Liver Cirrhosis, Experimental; Natriuresis; Neprilysin; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium; Sodium-Potassium-Exchanging ATPase; Thiorphan	2003
Phosphodiesterase-5A and neutral endopeptidase activities in human adipocytes do not control atrial natriuretic peptide-mediated lipolysis. British journal of pharmacology, 2007, Volume: 152, Issue:7 Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adult; Atrial Natriuretic Factor; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Humans; Kinetics; Lipolysis; Neprilysin; Phosphodiesterase 5 Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiorphan; Time Factors	2007
Changes in A-type natriuretic peptide and its receptors induced by a neutral endopeptidase inhibitor in a rat model of sepsis. Surgery today, 2008, Volume: 38, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Lung; Male; Protease Inhibitors; Rats; Receptors, Atrial Natriuretic Factor; Sepsis; Thiorphan	2008
Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. American journal of respiratory and critical care medicine, 2008, Oct-15, Volume: 178, Issue:8 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Atrial Natriuretic Factor; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Hypertension, Pulmonary; Male; Neprilysin; Piperazines; Protease Inhibitors; Pulmonary Artery; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Thiorphan; Treatment Outcome; Vascular Resistance; Vasodilation; Vasodilator Agents	2008
Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats. Kidney international, 2015, Volume: 88, Issue:1 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterial Pressure; Atrial Natriuretic Factor; Biphenyl Compounds; Body Weight; Endothelin B Receptor Antagonists; Endothelin-1; Irbesartan; Kidney; Myocardium; Myocytes, Cardiac; Neprilysin; Oligopeptides; Organ Size; Piperidines; Protease Inhibitors; Rats; Receptor, Angiotensin, Type 1; Receptor, Endothelin B; Renin-Angiotensin System; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Tetrazoles; Thiorphan; Up-Regulation; Vasoconstriction; Vasodilation	2015