Page last updated: 2024-08-16

thioridazine and phenytoin

thioridazine has been researched along with phenytoin in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199021 (60.00)18.7374
1990's0 (0.00)18.2507
2000's5 (14.29)29.6817
2010's9 (25.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Abraham, MH; Acree, WE; Ibrahim, A1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F1
Sen, S; Sinha, N1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Oettinger, L1
Curtis, JL; Swicord, W1
Aman, MG; Singh, NN1
Greendyke, RM; Gulya, A1
Muniz, C; Robinson, JD; Salem, RB; Sands, CD; Stewart, RB1
Itil, TM; Rizzo, AE1
Levitis, KA1
Masland, RL; Pippenger, CE; Siris, JH; Werner, WL1
Greene, NM1
Boelhouwer, C; Glueck, BC; Henry, CE1
Howell, MC; Rever, GW; Rutledge, A; Scholl, ML; Trowbridge, F1
Fletcher, BD; Lussier-Lazaroff, J1
Baldwin, RL; Peters, JE1
Hinz, JE; Pisciotta, AV; Ziebert, AP1
Abreu, BE; Sinclair, JG1
Gay, PE; Madsen, JA1
Auvinen, J; Linnoila, M; Vaisanen, K; Viukari, M1
Vincent, FM1
BARSA, JA; SAUNDERS, JC1

Reviews

3 review(s) available for thioridazine and phenytoin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Pediatric psychopharmacology. A review with special reference to deanol.
    Diseases of the nervous system, 1977, Volume: 38, Issue:12 Pt 2

    Topics: Adolescent; Adult; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Child, Preschool; Chlorpromazine; Deanol; Epilepsy; Ethanolamines; Heart Rate; Humans; Learning; Methylphenidate; Pemoline; Phenytoin; Rats; Syndrome; Thioridazine

1977
Halothane anesthesia and hepatitis in a high-risk population.
    The New England journal of medicine, 1973, Aug-09, Volume: 289, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Diazepam; Enzyme Induction; Halothane; Humans; Liver; Microsomes, Liver; Phenobarbital; Phenytoin; Postoperative Complications; Reserpine; Thioridazine; Time Factors

1973

Trials

1 trial(s) available for thioridazine and phenytoin

ArticleYear
Positive spiking: a double-blind control study on its significance in behavior disorders, both diagnostically and therapeutically.
    The American journal of psychiatry, 1968, Volume: 125, Issue:4

    Topics: Adolescent; Adult; Affective Symptoms; Bender-Gestalt Test; Clinical Trials as Topic; Cognition Disorders; Dissociative Disorders; Electroencephalography; Factor Analysis, Statistical; Female; Guilt; Humans; Male; Medical History Taking; Neurologic Manifestations; Personality Inventory; Phenytoin; Placebos; Psychiatric Status Rating Scales; Rorschach Test; Social Behavior Disorders; Social Work, Psychiatric; Thematic Apperception Test; Thioridazine

1968

Other Studies

31 other study(ies) available for thioridazine and phenytoin

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution

2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
Letter: Effects of medication of plasma vitamin A concentrations.
    Clinical chemistry, 1976, Volume: 22, Issue:5

    Topics: Humans; Intellectual Disability; Isosorbide Dinitrate; Phenobarbital; Phenytoin; Thioridazine; Vitamin A

1976
A critical appraisal of recent drug research in mental retardation: the Coldwater studies.
    Journal of mental deficiency research, 1986, Volume: 30 ( Pt 3)

    Topics: Aggression; Antipsychotic Agents; Attitude of Health Personnel; Discrimination Learning; Humans; Institutionalization; Intellectual Disability; Intelligence Tests; Lithium; Lithium Carbonate; Michigan; Phenytoin; Psychotropic Drugs; Social Behavior; Stereotyped Behavior; Substance Withdrawal Syndrome; Thioridazine

1986
Effect of pindolol administration on serum levels of thioridazine, haloperidol, phenytoin, and phenobarbital.
    The Journal of clinical psychiatry, 1988, Volume: 49, Issue:3

    Topics: Adult; Aged; Drug Interactions; Drug Therapy, Combination; Haloperidol; Humans; Male; Middle Aged; Neurocognitive Disorders; Phenobarbital; Phenytoin; Pindolol; Rage; Thioridazine; Violence

1988
Effect of thioridazine on phenytoin serum concentration: a retrospective study.
    Drug intelligence & clinical pharmacy, 1987, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Drug Interactions; Female; Humans; Male; Middle Aged; Phenytoin; Retrospective Studies; Thioridazine

1987
Behavior and quantitative EEG correlations during treatment of behavior-disturbed adolescents.
    Electroencephalography and clinical neurophysiology, 1967, Volume: 23, Issue:1

    Topics: Adolescent; Adolescent Psychiatry; Antisocial Personality Disorder; Behavior; Electroencephalography; Humans; Phenytoin; Thioridazine

1967
Letter: Need for medication in minimal brain dysfunction.
    Pediatrics, 1974, Volume: 54, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Humans; Methylphenidate; Phenytoin; Thioridazine

1974
Anticonvulsant drug-serum levels in psychiatric patients with seizure disorders. Effects of certain psychotropic drugs.
    New York state journal of medicine, 1974, Volume: 74, Issue:9

    Topics: Chlorpromazine; Chromatography, Gas; Diazepam; Drug Interactions; Epilepsy; Humans; Mental Disorders; Phenobarbital; Phenytoin; Thioridazine

1974
Hyperactivity in children: types, diagosis, drug therapy, approaches to management.
    Clinical pediatrics, 1972, Volume: 11, Issue:1

    Topics: Amphetamine; Anxiety; Attention; Attention Deficit Disorder with Hyperactivity; Brain Damage, Chronic; Child; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Diazepam; Environment; Family; Female; Humans; Hyperkinesis; Methylphenidate; Motor Skills; Phenytoin; Thioridazine

1972
Rickets and anticonvulsant therapy in children: a roentgenologic investigation.
    Journal of the Canadian Association of Radiologists, 1971, Volume: 22, Issue:2

    Topics: Adolescent; Anticonvulsants; Benzazepines; Child; Dextroamphetamine; Diazepam; Ethosuximide; Female; Hand; Humans; Knee; Male; Methylphenidate; Phenobarbital; Phenytoin; Primidone; Radiography; Rickets; Thioridazine; Time Factors

1971
Hematologic complications from tranquilizers in children.
    Southern medical journal, 1968, Volume: 61, Issue:10

    Topics: Adolescent; Age Factors; Agranulocytosis; Bone Marrow Examination; Brain Damage, Chronic; Brain Diseases; Child; Dextroamphetamine; Eosinophilia; Female; Fluphenazine; Humans; Imipramine; Leukocyte Count; Leukocytosis; Leukopenia; Male; Methylphenidate; Phenobarbital; Phenytoin; Sex Factors; Thioridazine; Tranquilizing Agents

1968
Effect of chlorpromazine on DNA synthesis in a cell free system.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 120, Issue:2

    Topics: Aminopyrine; Animals; Aspirin; Chlorpromazine; Diphenhydramine; DNA; In Vitro Techniques; Liver; Liver Regeneration; Phenytoin; Rats; Subcellular Fractions; Thioridazine; Thymidine

1965
Transplacental effects of drugs in mice.
    Texas reports on biology and medicine, 1965,Winter, Volume: 23, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcellulose; Mice; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Thalidomide; Thioridazine; Tranquilizing Agents; Urethane

1965
Interaction between phenobarbital and thioridazine.
    Neurology, 1983, Volume: 33, Issue:12

    Topics: Anticonvulsants; Drug Interactions; Humans; Phenobarbital; Phenytoin; Thioridazine

1983
Effect of anticonvulsants on plasma haloperidol and thioridazine levels.
    The American journal of psychiatry, 1980, Volume: 137, Issue:7

    Topics: Adult; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Female; Haloperidol; Humans; Intellectual Disability; Male; Mesoridazine; Phenobarbital; Phenytoin; Thioridazine

1980
Phenothiazine-induced phenytoin intoxication.
    Annals of internal medicine, 1980, Volume: 93, Issue:1

    Topics: Adult; Aged; Ataxia; Drug Interactions; Dysarthria; Female; Humans; Male; Nystagmus, Pathologic; Phenytoin; Thioridazine

1980
BENZQUINAMIDE IN THE TREATMENT OF PSYCHOTIC PATIENTS.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Chlorpromazine; Chlorprothixene; Drug Therapy; Humans; Mental Disorders; Phenytoin; Psychotic Disorders; Quinolizines; Thioridazine; Tranquilizing Agents; Trifluoperazine; Trimeprazine

1964