thioridazine has been researched along with clozapine in 132 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 64 (48.48) | 18.7374 |
| 1990's | 26 (19.70) | 18.2507 |
| 2000's | 29 (21.97) | 29.6817 |
| 2010's | 13 (9.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ellefson, CR; Kehr, JR; Miller, A; Woo, CM | 1 |
| Bernstein, E; Dextraze, P; Eison, MS; Lobeck, WG; New, JS; Taylor, DP; Temple, DL; Yevich, JP; Yocca, FD | 1 |
| George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Catt, JD; Eison, MS; Lobeck, WG; Minielli, JL; New, JS; Riblet, LA; Smith, DW; Taylor, DP; Temple, DL; Yevich, JP | 1 |
| Butler, DE; Coughenour, LL; DeWald, HA; Downs, DA; Heffner, TG; Lustgarten, D; Pugsley, TA; Wise, LD | 1 |
| Butler, DE; Coughenour, LL; DeWald, HA; Downs, DA; Heffner, TG; Lustgarten, DM; Pattison, IC; Pugsley, TA; Schweiss, DN; Wise, LD | 1 |
| Beeson, NW; Coughenour, LL; DeWald, HA; Downs, DA; Heffner, TG; Hershenson, FM; Pugsley, TA; Wise, LD | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Chakrabarti, JK; Horsman, L; Hotten, TM; Pullar, IA; Tupper, DE; Wright, FC | 1 |
| Chakrabarti, JK; Fairhurst, J; Gutteridge, NJ; Horsman, L; Pullar, IA; Smith, CW; Steggles, DJ; Tupper, DE; Wright, FC | 1 |
| New, JS; Riblet, LA; Taylor, DP; Temple, DL; Yevich, JP | 1 |
| Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Ikeda, K; Kobayashi, T; Kumanishi, T | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Grinde, E; Herrick-Davis, K; Teitler, M | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Ernsberger, P; Hufeisen, SJ; Jayathilake, K; Kroeze, WK; Meltzer, HY; Popadak, BA; Renock, SM; Roth, BL; Steinberg, S | 1 |
| Glennon, RA | 1 |
| Keserü, GM | 1 |
| Li, J; Rajamani, R; Reynolds, CH; Tounge, BA | 1 |
| Herrick-Davis, K; Purohit, A; Smith, C; Teitler, M | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Jia, L; Sun, H | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Giordanetto, F; Leach, AG; Zachariae, U | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Sen, S; Sinha, N | 1 |
| Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Modestin, J; Petrin, A | 1 |
| Bartholini, G | 1 |
| Gründig, E; Weiss, J | 1 |
| Bowers, MB; Rozitis, A | 2 |
| Ahlenius, S; Engel, J | 1 |
| Carroll, BJ; Curtis, GC; Kokmen, E | 1 |
| Setler, P; Weidley, E; Zarevics, P | 1 |
| Honma, T; Kitagawa, S | 1 |
| Herman, RL; Kubena, RK; Malick, JB | 1 |
| Beart, PM; Gundlach, AL; McDonald, D | 1 |
| Buus Lassen, J | 1 |
| Bloss, JL; Singer, GH | 1 |
| Gerlach, J; Simmelsgaard, H | 1 |
| Canon, JG | 1 |
| Sedvall, G; Wiesel, FA | 1 |
| Costa, E; Guidotti, A; Revuelta, A; Zivkovic, B | 1 |
| Dingell, JV; Hill, H; Robinson, SE; Setler, P; Stawarz, RJ; Sulser, F | 1 |
| Iversen, SD; Koob, GF | 1 |
| Del Fiacco, M; Iversen, SD; Koob, GF | 1 |
| Costall, B; Naylor, RJ | 4 |
| Gudelsky, GA; Moore, KE | 1 |
| Korf, J; Westerink, BH | 1 |
| Maître, L; Waldmeier, PC | 2 |
| Davis, JM; Smith, RC | 1 |
| Fukushima, H; Honma, T | 1 |
| Fielding, S; Lal, H; Marky, M | 1 |
| Kelly, PH; Miller, RJ | 1 |
| Asper, H; Bürki, HR; Ruch, W | 1 |
| Manian, AA; Palmer, GC; Spiker, MD | 1 |
| Budygin, EA; Gaĭnetdinov, RR; Kovalev, GI; Kudrin, VS; Raevskiĭ, KS | 1 |
| Jolicoeur, FB; Marsden, CA; Rivest, R | 1 |
| Kirch, DG; McAllister, CG; Pickar, D; Rapaport, MH | 1 |
| Fink, H; Morgenstern, R; Ott, T; Schremmer, C | 1 |
| Amato, G; Calzà, L; Giardino, L; Piazza, PV; Zanni, M | 1 |
| Bolden, C; Cusack, B; Richelson, E | 1 |
| Amdur, RL; Carvey, PM; Kao, LC; Klawans, HL; Lin, DH; Nath, ST; Singh, R; Zhang, TJ | 1 |
| Blackburn, JR; Phillips, AG | 1 |
| Ekker, M; Sourkes, TL | 1 |
| Kovacic, B; Ruffing, D; Stanley, M | 1 |
| Cohen, BM; Lipinski, JF | 1 |
| Blaha, CD; Lane, RF | 2 |
| Cools, AR; Ellenbroek, BA; Honig, WM; Peeters, BW | 1 |
| Rebec, GV; Tschanz, JT | 1 |
| Maidment, NT; Marsden, CA | 1 |
| Boiadzhieva, N | 1 |
| Greenberg, D; Snyder, SH; Yamumura, HI | 1 |
| Schechter, MD | 1 |
| Barghon, R; Colboc, O; Costentin, J; Protais, P | 1 |
| de Belleroche, JS; Neal, MJ | 1 |
| Leander, JD | 1 |
| Borison, RL; Diamond, BI | 1 |
| Alloway, KD; Bashore, TR; Gelman, J; Rebec, GV | 1 |
| MacDonald, C; Robertson, A | 1 |
| DeWeese, J; Goldberg, DM; Goldberg, SR; Kelleher, RT; Spealman, RD | 1 |
| Angeby, T; Haglund, L; Köhler, C; Ogren, SO | 1 |
| Kim, HS; Liebman, J; Welch, JJ | 1 |
| Baldessarini, RJ; Gardner, DM; Garver, DL | 1 |
| Assié, MB; Koek, W; Sleight, AJ | 1 |
| Hakola, P; Tiihonen, J; Vartiainen, H | 1 |
| Mueller, K | 1 |
| Compton, AD; Porter, JH; Wiley, JL | 1 |
| Chai, BL; Meltzer, HY; Thompson, PA; Yamamoto, BK | 1 |
| Marr, I; Schlicker, E | 1 |
| Champion, M; Cousins, MS; Kovach, J; Maio, C; Salamone, JD; Turski, T | 1 |
| Kapur, S; Seeman, P | 1 |
| Bunker, MT; Marken, PA; Ruehter, VL; Schneiderhan, ME | 1 |
| de Leon, J; Simpson, GM; Stanilla, JK | 1 |
| Aberman, J; Carriero, D; Finn, M; Lyons, M; Salamone, JD; Trevitt, JT | 1 |
| Loupe, PS; Schroeder, SR; Tessel, RE | 1 |
| Aberman, J; Atherton, A; Salamone, JD; Trevitt, J | 1 |
| Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Dai, J; Fowler, WL; Ichikawa, J; Meltzer, HY; O'Laughlin, IA | 1 |
| Philibin, SD; Porter, JH; Vann, RE; Varvel, SA; Wise, LE | 1 |
| Nomikos, GG; Rodriguez, DE; Shirazi-Southall, S | 1 |
| Bilker, WB; Glasser, DB; Hennessy, S; Kimmel, SE; Knauss, JS; Margolis, DJ; Morrison, MF; Reynolds, RF; Strom, BL | 1 |
| Gupta, S | 1 |
| Anziano, R; Cutler, NR; Harrigan, EP; Miceli, JJ; Middle, M; Reeves, KR; Shiovitz, T; Sramek, J; Watsky, E | 1 |
| Curtis, LH; Dans, PE; Hutchison, S; Krishnan, RR; Masselink, LE; Schulman, KA; Wright, A; Østbye, T | 1 |
| Lawrie, S; McIntosh, A; Nadeem, Z | 1 |
| Danovich, L; Gavish, M; Lahav, M; Leschiner, S; Shuster, V; Veenman, L; Weizman, A | 1 |
| Goodwin, DG; Lindsay, DS; Strobl, JS | 1 |
| Hall, K; Lewitt, M; Melkersson, K | 1 |
| Flanagan, RJ; Handley, S; Patel, MX | 1 |
| Asghari, A; Bazregar, M; Boutorabi, L; Fahimi, E; Rajabi, M | 1 |
8 review(s) available for thioridazine and clozapine
| Article | Year |
|---|---|
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Correlation between plasma concentration and clinical effect of neuroleptics and antidepressants].
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Fluphenazine; Humans; Imipramine; Nortriptyline; Perazine; Phenelzine; Thioridazine | 1976 |
Electrochemistry in vivo: application to CNS pharmacology.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dopamine; Electrochemistry; Thioridazine | 1986 |
Clozapine withdrawal resulting in delirium with psychosis: a report of three cases.
Topics: Adult; Clozapine; Delirium; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Male; Middle Aged; Psychoses, Substance-Induced; Psychotic Disorders; Receptors, Dopamine; Recurrence; Schizophrenia; Schizophrenia, Paranoid; Substance Withdrawal Syndrome; Thioridazine | 1997 |
Safety in treating bipolar disorder.
Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Clozapine; Diabetes Mellitus; Dibenzothiazepines; Dyskinesias; Haloperidol; Humans; Hyperglycemia; Hyperprolactinemia; Olanzapine; Pirenzepine; Quetiapine Fumarate; Risperidone; Thioridazine; Weight Gain | 2003 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Chlorpromazine; Clozapine; Cognitive Behavioral Therapy; Dibenzothiepins; Family Therapy; Haloperidol; Humans; Patient Compliance; Risperidone; Schizophrenia; Secondary Prevention; Sulpiride; Thioridazine | 2005 |
Antipsychotic-related fatal poisoning, England and Wales, 1993-2013: impact of the withdrawal of thioridazine.
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Drug Recalls; England; Heroin; Humans; Methadone; Morphine; Olanzapine; Poisoning; Quetiapine Fumarate; Thioridazine; Wales | 2016 |
2 trial(s) available for thioridazine and clozapine
| Article | Year |
|---|---|
Tardive dyskinesia during and following treatment with haloperidol, haloperidol + biperiden, thioridazine, and clozapine.
Topics: Aged; Biperiden; Clinical Trials as Topic; Clozapine; Dibenzazepines; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Parkinson Disease, Secondary; Piperidines; Psychotic Disorders; Thioridazine | 1978 |
A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.
Topics: Adolescent; Adult; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Biotransformation; Clozapine; Dibenzothiazepines; Electrocardiography; Female; Haloperidol; Heart Conduction System; Humans; Long QT Syndrome; Male; Middle Aged; Olanzapine; Quetiapine Fumarate; Risperidone; Thioridazine | 2004 |
122 other study(ies) available for thioridazine and clozapine
| Article | Year |
|---|---|
Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antipsychotic Agents; Avoidance Learning; Brain; Clozapine; Corpus Striatum; Dextroamphetamine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Rats | 1978 |
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Molecular Structure; Piperazines; Pyrimidines; Rats; Receptors, Dopamine D2; Stereoisomerism; Stereotyped Behavior | 1992 |
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Catalepsy; Cerebral Cortex; Corpus Striatum; Isoxazoles; Male; Models, Molecular; Norepinephrine; Oxazoles; Physostigmine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sleep; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles | 1986 |
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Ataxia; Avoidance Learning; Brain; Cebus; Chemical Phenomena; Chemistry; Dopamine; Male; Mice; Motor Activity; Movement Disorders; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Dopamine; Saimiri | 1986 |
1,3-Dialkyl-4-(iminoarylmethyl)-1H-pyrazol-5-ols. A series of novel potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Corpus Striatum; Membranes; Mice; Motor Activity; Rats; Receptors, Dopamine; Saimiri; Self Stimulation | 1987 |
Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Cebus; Imidazoles; Mice; Motor Activity; Pyrazoles; Pyrimidines; Rats; Receptors, Dopamine; Structure-Activity Relationship | 1988 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
4-Piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Body Temperature; Catalepsy; Humans; Lethal Dose 50; Mice; Piperazines; Rats; Structure-Activity Relationship | 1980 |
10-Piperazinyl-4H-theino[3,2-b][1,5]- and -[3,4-b][1,5]benzodiazepines as potential neuroleptics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Body Temperature; Catalepsy; Humans; Lethal Dose 50; Mice; Piperazines; Rats | 1980 |
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Buspirone; Corpus Striatum; Kinetics; Male; Models, Molecular; Molecular Conformation; Piperazines; Pyrimidines; Rats; Receptors, Dopamine; Spiperone; Structure-Activity Relationship | 1983 |
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin | 1994 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Haloperidol; Heart; Mice; Oocytes; Pimozide; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Thioridazine; Xenopus laevis | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.
Topics: Animals; Antipsychotic Agents; COS Cells; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Radioligand Assay; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Receptor Agonists | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Discriminant Analysis; Drug Evaluation, Preclinical; Forecasting; Humans; Protein Binding; Receptors, Histamine H1; Statistics, Nonparametric; Weight Gain | 2003 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
A two-state homology model of the hERG K+ channel: application to ligand binding.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation | 2005 |
Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs.
Topics: Amino Acid Substitution; Antipsychotic Agents; Cell Line; Cyclic AMP; Humans; Mutagenesis, Site-Directed; Mutation; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system.
Topics: Animals; Caudate Nucleus; Chlorpromazine; Clozapine; Dopamine; Extrapyramidal Tracts; Haloperidol; Homovanillic Acid; Limbic System; Male; Olfactory Bulb; Rats; Sulpiride; Thioridazine; Tranquilizing Agents | 1976 |
[The influence of neuroleptic drugs on urinary excretion of non-protein nitrogen (author's transl)].
Topics: Amino Acids; Clopenthixol; Clozapine; Creatinine; Delayed-Action Preparations; Flupenthixol; Fluphenazine; Humans; Hydrogen-Ion Concentration; Ion Exchange Resins; Nitrogen; Procyclidine; Schizophrenia; Thioridazine; Tranquilizing Agents; Urea | 1976 |
Brain homovanillic acid: regional changes over time with antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Caudate Nucleus; Chlorpromazine; Clozapine; Drug Tolerance; Fluphenazine; Homovanillic Acid; Hypothalamus; Limbic System; Male; Phenylacetates; Rabbits; Thioridazine; Time Factors | 1976 |
Potentiation by alpha-methyltyrosine of the suppression of food-reinforced lever-pressing behaviour induced by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Catecholamines; Chlorpromazine; Clozapine; Conditioning, Operant; Drug Synergism; Feeding Behavior; Haloperidol; Male; Methyltyrosines; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Thioridazine | 1977 |
Paradoxical response to dopamine agonists in tardive dyskinesia.
Topics: Adrenergic alpha-Agonists; Adult; Amantadine; Apomorphine; Benztropine; Clozapine; Deanol; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Levodopa; Physostigmine; Receptors, Dopamine; Reserpine; Stimulation, Chemical; Thioridazine | 1977 |
Brain homovanillic acid: regional changes following chronic antipsychotic drug administration.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Chlorpromazine; Clozapine; Drug Tolerance; Fluphenazine; Haloperidol; Homovanillic Acid; Male; Phenylacetates; Rabbits; Thioridazine; Time Factors | 1977 |
Blockade of intracranial self-stimulation by antipsychotic drugs: failure to correlate with central alpha-noradrenergic blockade.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Depression, Chemical; Electric Stimulation; Male; Muscle Contraction; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Reflex; Self Stimulation; Thioridazine; Time Factors | 1977 |
[Effects of minor tranquilizers and neuroleptics on open-field behavior in rats (author's transl)].
Topics: Animals; Anti-Anxiety Agents; Butyrophenones; Chlorpromazine; Clozapine; Defecation; Haloperidol; Male; Methamphetamine; Motor Activity; Rats; Thioridazine; Tranquilizing Agents; Trifluperidol | 1977 |
A comparison between a new antipsychotic screening technique (shelf jump avoidance) and a classical discriminative avoidance paradigm.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Chlorpromazine; Clozapine; Conditioning, Classical; Discrimination Learning; Dose-Response Relationship, Drug; Haloperidol; Male; Rats; Thioridazine | 1979 |
Mesolimbic dopaminergic neurones and somatodendritic mechanisms.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benztropine; Clozapine; Dendrites; Dopamine; Male; Nucleus Accumbens; Rats; Septal Nuclei; Synaptic Transmission; Tegmentum Mesencephali; Thioridazine; Tyrosine 3-Monooxygenase | 1979 |
Inhibition of 4,alpha-dimethyl-m-tyramine (H 77/77)-induced hypermotility in rats by single and repeated administration of chloropromazine, haloperidol, clozapine and thioridazine.
Topics: Adrenergic Agents; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Haloperidol; Motor Activity; Rats; Thioridazine; Tyramine | 1975 |
Neuropharmacological and behavioral evaluation of prostaglandin E2 and 11-thiol-11-desoxy prostaglandin E2 in the mouse and rat.
Topics: Animals; Avoidance Learning; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Fluphenazine; Haloperidol; Humans; Male; Mice; Motor Activity; Physostigmine; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Stereotyped Behavior; Thioridazine | 1978 |
A comparison of clozapine, chlorpromazine, and thioridazine upon DRL performance in the squirrel monkey.
Topics: Animals; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Dose-Response Relationship, Drug; Female; Haplorhini; Male; Reinforcement Schedule; Saimiri; Thioridazine | 1979 |
Effect of antipsychotic drugs on homovanillic acid levels in striatum and olfactory tubercle of the rat.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Male; Olfactory Bulb; Phenylacetates; Rats; Stimulation, Chemical; Thioridazine | 1975 |
Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Catecholamines; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzothiepins; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Hypothalamus; Kinetics; Male; Norepinephrine; Pimozide; Promethazine; Rats; Thioridazine; Tyrosine 3-Monooxygenase | 1975 |
On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Homovanillic Acid; Humans; Limbic System; Male; Phenylacetates; Pimozide; Rats; Receptors, Drug; Rotation; Stereotyped Behavior; Substantia Nigra; Thioridazine | 1975 |
Behavioral implications of dopaminergic neurons in the mesolimbic system.
Topics: Animals; Behavior, Animal; Caudate Nucleus; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; Humans; Limbic System; Motor Activity; Neural Pathways; Neurons; Olfactory Bulb; Rats; Stereotyped Behavior; Thioridazine | 1977 |
Dissociable properties of dopamine neurons im the nigrostriatal and mesolimbic dopamine systems.
Topics: Animals; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; Drug Interactions; Ethanolamines; gamma-Aminobutyric Acid; Humans; Limbic System; Neural Pathways; Neurons; Olfactory Bulb; Rats; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra; Thioridazine | 1977 |
A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Fluphenazine; Haloperidol; Limbic System; Male; Metoclopramide; Pimozide; Rats; Stereotaxic Techniques; Sulpiride; Thioridazine; Tranquilizing Agents | 1976 |
A comparison of the effects of haloperidol on dopamine turnover in the striatum, olfactory tubercule and median eminence.
Topics: Animals; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Hypophysectomy; Hypothalamo-Hypophyseal System; Male; Median Eminence; Methyltyrosines; Olfactory Bulb; Rats; Thioridazine; Time Factors | 1977 |
Acidic dopamine metabolites in cortical areas of the rat brain: localization and effects of drug.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Cerebral Cortex; Clozapine; Corpus Striatum; Haloperidol; Homovanillic Acid; Male; Morphine; Olfactory Bulb; Oxotremorine; Phenylacetates; Probenecid; Rats; Sulpiride; Thioridazine | 1976 |
Clozapine: reduction of the initial dopamine turnover increase by repeated treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Tolerance; Female; Homovanillic Acid; Limbic System; Rats; Thioridazine; Time Factors | 1976 |
Behavioral evidence for supersensitivity after chronic administration of haloperidol, clozapine, and thioridazine.
Topics: Animals; Apomorphine; Behavior; Clozapine; Dibenzazepines; Dopamine; Haloperidol; Humans; Motor Activity; Rats; Receptors, Drug; Stereotyped Behavior; Thioridazine; Time Factors | 1976 |
On the relevance of preferential increases of mesolimbic versus striatal dopamine turnover for the prediction of antipsychotic activity of psychotropic drugs.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anthracenes; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Haloperidol; Homovanillic Acid; Humans; Limbic System; Male; Methyltyrosines; Psychotic Disorders; Psychotropic Drugs; Rats; Sulpiride; Thioridazine | 1976 |
Correlation between catalepsy and dopamine decrease in the rat striatum induced by neuroleptics.
Topics: Animals; Butyrophenones; Catalepsy; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Rats; Sulpiride; Thioridazine; Time Factors; Tranquilizing Agents; Trifluperidol | 1976 |
Effect of neuroleptic drugs on mouse jumping induced by L-DOPA in amphetamine treated mice.
Topics: Amphetamine; Animals; Behavior; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Humans; Levodopa; Male; Mice; Pimozide; Promethazine; Psychotropic Drugs; Stereotyped Behavior; Thioridazine; Tranquilizing Agents | 1976 |
The interaction of neuroleptic and muscarinic agents with central dopaminergic systems.
Topics: Adenylyl Cyclase Inhibitors; Animals; Apomorphine; Behavior, Animal; Chlorpromazine; Clopenthixol; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Flupenthixol; Male; Methamphetamine; Models, Biological; Oxotremorine; Parasympathomimetics; Pimozide; Rats; Scopolamine; Substantia Nigra; Thioridazine; Tranquilizing Agents | 1975 |
Detection of the nueroleptic properties of clozapine, sulpiride and thioridazine.
Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Synergism; Fluphenazine; Haloperidol; Humans; Isoquinolines; Male; Methyltyrosines; Pimozide; Rats; Spiro Compounds; Stereotyped Behavior; Succinimides; Sulpiride; Thioridazine; Tranquilizing Agents | 1975 |
Antagonism of the hyperactivity induced by dopamine applied intracerebrally to the nucleus accumbens septi by typical neuroleptics and by clozapine, sulpiride and thioridazine.
Topics: Animals; Clozapine; Dibenzazepines; Dopamine; Dopamine Antagonists; Male; Motor Activity; Rats; Stimulation, Chemical; Sulpiride; Thioridazine; Time Factors; Tranquilizing Agents | 1976 |
Effect of clozapine on the metabolism of serotonin in rat brain.
Topics: Animals; Brain; Brain Stem; Clozapine; Dibenzazepines; Haloperidol; Hydroxyindoleacetic Acid; Limbic System; Loxapine; Male; Rats; Serotonin; Thioridazine; Tryptophan; Tryptophan Hydroxylase | 1976 |
Action of neuroleptic agents on histamine-sensitive adenylate cyclase in rabbit cerebral cortex.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Cerebral Cortex; Chlorpromazine; Clozapine; Haloperidol; Histamine; Promethazine; Rabbits; Thioridazine; Tranquilizing Agents | 1976 |
[Different effects of typical and atypical neuroleptics on K+-stimulated dopamine release from isolated rat striatum].
Topics: Animals; Antipsychotic Agents; Carbolines; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; In Vitro Techniques; Male; Metoclopramide; Potassium; Raclopride; Rats; Rats, Wistar; Remoxipride; Salicylamides; Stimulation, Chemical; Sulpiride; Thioridazine; Tiapamil Hydrochloride; Trifluoperazine | 1992 |
Use of amfonelic acid to discriminate between classical and atypical neuroleptics and neurotensin: an in vivo voltammetric study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Cerebral Ventricles; Clozapine; Corpus Striatum; Electrochemistry; Haloperidol; Injections, Intraventricular; Male; Nalidixic Acid; Naphthyridines; Neurotensin; Perphenazine; Rats; Rats, Inbred Strains; Thioridazine | 1991 |
The effects of typical and atypical neuroleptics on mitogen-induced T lymphocyte responsiveness.
Topics: Adult; Antigens, Differentiation; Antipsychotic Agents; CD5 Antigens; Clozapine; Female; Fluphenazine; Haloperidol; Humans; Lymphocyte Activation; Male; Schizophrenia; Schizophrenic Psychology; T-Lymphocytes; Thioridazine | 1991 |
Atypical neuroleptics suppress dopaminergic behavioral supersensitivity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Cyproheptadine; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Ritanserin; Serotonin Antagonists; Sulpiride; Thioridazine | 1990 |
DA2/NT receptor balance in the mesostriatal and mesolimbocortical systems after chronic treatment with typical and atypical neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Cerebral Cortex; Chlorpromazine; Clozapine; Corpus Striatum; Haloperidol; Limbic System; Male; Neurotensin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotensin; Receptors, Neurotransmitter; Thioridazine; Time Factors | 1990 |
Clozapine is a potent and selective muscarinic antagonist at the five cloned human muscarinic acetylcholine receptors expressed in CHO-K1 cells.
Topics: Animals; Atropine; Cell Line; Chlorpromazine; Clozapine; Cricetinae; Cricetulus; Female; Humans; Parasympatholytics; Quinuclidinyl Benzilate; Receptors, Muscarinic; Thioridazine | 1991 |
Clozapine fails to prevent the development of haloperidol-induced behavioral hypersensitivity in a cotreatment paradigm.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Clozapine; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine | 1990 |
Blockade of acquisition of one-way conditioned avoidance responding by haloperidol and metoclopramide but not by thioridazine or clozapine: implications for screening new antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Dibenzazepines; Drug Evaluation, Preclinical; Haloperidol; Male; Metoclopramide; Rats; Thioridazine | 1989 |
Differential effects of thioridazine, clozapine and metoclopramide on the induction of adrenomedullary enzymes by apomorphine.
Topics: Adrenal Medulla; Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Enzyme Induction; Male; Metoclopramide; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Substantia Nigra; Thioridazine; Tyrosine 3-Monooxygenase | 1985 |
Effect of neuroleptics and of potential new antipsychotic agents (MJ 13859-1 and MJ 13980-1) on a monkey model of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Cebus; Chlorpromazine; Clozapine; Dyskinesia, Drug-Induced; Female; Haloperidol; Motor Activity; Posture; Spiro Compounds; Thioridazine | 1986 |
In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: implications for drug mechanisms of action.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; Clozapine; Fluphenazine; Haloperidol; Kinetics; Male; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Thioridazine | 1986 |
Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Male; Metoclopramide; Nucleus Accumbens; Promethazine; Rats; Rats, Inbred Strains; Septal Nuclei; Thioridazine | 1987 |
The paw test: a behavioural paradigm for differentiating between classical and atypical neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Forelimb; Haloperidol; Hindlimb; Male; Metoclopramide; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Thioridazine | 1987 |
Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy.
Topics: Animals; Behavior, Animal; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Rats; Rats, Inbred Strains; Stereotyped Behavior; Thioridazine | 1988 |
Repeated atypical neuroleptic administration: effects on central dopamine metabolism monitored by in vivo voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Brain Chemistry; Clozapine; Corpus Striatum; Dibenzazepines; Electrochemistry; Male; Nucleus Accumbens; Phenylacetates; Rats; Rats, Inbred Strains; Thioridazine; Time Factors | 1987 |
[Effect of psychotropic drugs on the luteotropic function of the adenohypophysis].
Topics: Animals; Clozapine; Dibenzazepines; Male; Nialamide; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Thioridazine | 1986 |
Antischizophrenic drugs: affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effects.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Binding, Competitive; Brain; Chlorpromazine; Clozapine; Fluphenazine; Guinea Pigs; Haloperidol; Haplorhini; Humans; In Vitro Techniques; Perphenazine; Phenothiazines; Promazine; Rats; Receptors, Cholinergic; Schizophrenia; Thioridazine; Trifluoperazine; Triflupromazine | 1974 |
Effect of neuroleptics and tricyclic antidepressants upon d-amphetamine discrimination.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imipramine; Male; Nortriptyline; Promethazine; Rats; Sodium Chloride; Thioridazine; Trifluoperazine | 1980 |
Hypokinesia in mice and catalepsy in rats elicited by morphine associated with antidopaminergic agents, including atypical neuroleptics.
Topics: alpha-Methyltyrosine; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Clozapine; Haloperidol; Humans; Male; Methyltyrosines; Mice; Morphine; Motor Activity; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Thioridazine | 1981 |
The contrasting effects of neuroleptics on transmitter release from the nucleus accumbens and corpus striatum.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Atropine; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Female; Haloperidol; Neurotransmitter Agents; Nucleus Accumbens; Potassium; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Dopamine; Septal Nuclei; Thioridazine | 1982 |
Interactions of clozapine, thioridazine, and mezilamine with oxotremorine on schedule-controlled responding.
Topics: Animals; Antipsychotic Agents; Clozapine; Columbidae; Conditioning, Psychological; Dibenzazepines; Dose-Response Relationship, Drug; Drug Interactions; Male; Oxotremorine; Pyrimidines; Thioridazine; Time Factors | 1983 |
Regional selectivity of neuroleptic drugs: an argument for site specificity.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Fluphenazine; Haloperidol; Limbic System; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thioridazine | 1983 |
Cataleptogenic potency of the antipsychotic drugs is inversely correlated with neuronal activity in the amygdaloid complex of the rat.
Topics: Action Potentials; Amygdala; Animals; Antipsychotic Agents; Catalepsy; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Neurons; Pimozide; Rats; Rats, Inbred Strains; Thioridazine | 1983 |
Atypical neuroleptics clozapine and thioridazine enhance amphetamine-induced stereotypy.
Topics: Animals; Clozapine; Dextroamphetamine; Dibenzazepines; Drug Interactions; Humans; Male; Motor Activity; Pimozide; Rats; Stereotyped Behavior; Thioridazine; Time Factors | 1984 |
Behavioral effects of clozapine: comparison with thioridazine, chlorpromazine, haloperidol and chlordiazepoxide in squirrel monkeys.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Electroshock; Food; Haloperidol; Male; Reinforcement Schedule; Saimiri; Thioridazine; Tranquilizing Agents | 1983 |
Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Chlorpromazine; Clozapine; Haloperidol; Humans; Hyperkinesis; Kinetics; Organ Specificity; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior; Sulpiride; Thioridazine | 1981 |
Amphetamine-induced increases in dopaminergic single cell firing rate after haloperidol pretreatment. Correlation with extrapyramidal side effects.
Topics: Animals; Apomorphine; Brain; Clozapine; Dextroamphetamine; Dopamine; Drug Interactions; Extrapyramidal Tracts; Haloperidol; Male; Metoclopramide; Neurons; Rats; Substantia Nigra; Thioridazine | 1980 |
Conversions from clozapine to other antipsychotic drugs.
Topics: Antipsychotic Agents; Clozapine; Humans; Receptors, Dopamine; Risk Factors; Sulpiride; Thioridazine | 1995 |
Biphasic displacement of [3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics.
Topics: Animals; Antipsychotic Agents; Benzamides; Brain; Clozapine; Corpus Striatum; Dopamine D2 Receptor Antagonists; In Vitro Techniques; Isoxazoles; Male; Olfactory Pathways; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Risperidone; Spiperone; Thioridazine | 1993 |
Carbamazepine-induced changes in plasma levels of neuroleptics.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Clozapine; Female; Humans; Male; Middle Aged; Oxcarbazepine; Thioridazine | 1995 |
Locomotor stereotypy is produced by methylphenidate and amfonelic acid and reduced by haloperidol but not clozapine or thioridazine.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Methylphenidate; Motor Activity; Nalidixic Acid; Naphthyridines; Rats; Rats, Wistar; Stereotyped Behavior; Thioridazine | 1993 |
Effects of four antipsychotics on punished responding in rats.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Clozapine; Conflict, Psychological; Drug Evaluation, Preclinical; Haloperidol; Male; Punishment; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Structure-Activity Relationship; Thioridazine | 1993 |
Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Transport; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Scopolamine; Thioridazine | 1994 |
Behavioural interactions between 5-hydroxytryptophan, neuroleptic agents and 5-HT receptor antagonists in modifying rodent responding to aversive situations.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benperidol; Clozapine; Drug Interactions; Haloperidol; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Ritanserin; Serotonin; Serotonin Antagonists; Social Behavior; Sulpiride; Thioridazine | 1995 |
The moderate affinity of clozapine at H3 receptors is not shared by its two major metabolites and by structurally related and unrelated atypical neuroleptics.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Binding, Competitive; Clozapine; Dibenzothiepins; Dose-Response Relationship, Drug; Histamine Antagonists; Isotope Labeling; Male; Methylhistamines; Mice; Olanzapine; Pirenzepine; Rats; Rats, Wistar; Receptors, Histamine H3; Remoxipride; Risperidone; Structure-Activity Relationship; Thioridazine; Tritium | 1996 |
Different behavioral effects of haloperidol, clozapine and thioridazine in a concurrent lever pressing and feeding procedure.
Topics: Animals; Antipsychotic Agents; Clozapine; Conditioning, Operant; Feeding Behavior; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Thioridazine; Time Factors | 1996 |
Clozapine occupies high levels of dopamine D2 receptors.
Topics: Antipsychotic Agents; Binding, Competitive; Brain; Clozapine; Haloperidol; Humans; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Solubility; Thioridazine | 1997 |
Attenuation of antipsychotic-induced hyperprolactinemia with clozapine.
Topics: Adolescent; Amenorrhea; Antipsychotic Agents; Bromocriptine; Clozapine; Female; Fluphenazine; Galactorrhea; Haloperidol; Humans; Hyperprolactinemia; Prolactin; Psychotic Disorders; Thioridazine | 1997 |
Effects of clozapine, thioridazine, risperidone and haloperidol on behavioral tests related to extrapyramidal motor function.
Topics: Animals; Antipsychotic Agents; Cholinesterase Inhibitors; Clozapine; Conditioning, Operant; Extrapyramidal Tracts; Haloperidol; Jaw; Male; Rats; Rats, Sprague-Dawley; Risperidone; Tacrine; Thioridazine | 1997 |
Effects of neuroleptic and anticonvulsant drugs on repeated acquisition learning in microencephalic and normal rats.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Brain; Clozapine; Conditioning, Operant; Female; Learning; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens; Thioridazine | 1997 |
Effects of subchronic administration of clozapine, thioridazine and haloperidol on tests related to extrapyramidal motor function in the rat.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Conditioning, Operant; Haloperidol; Jaw; Male; Movement; Rats; Rats, Sprague-Dawley; Tacrine; Thioridazine | 1998 |
Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Membranes; Piperazines; Piperidines; Pyridines; Pyrimidinones; Pyrrolidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Thiazoles; Thioridazine; Tritium | 2001 |
Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Cholinesterase Inhibitors; Clozapine; Corpus Striatum; Haloperidol; Male; Nucleus Accumbens; Olanzapine; Oxotremorine; Piperazines; Pirenzepine; Rats; Rats, Sprague-Dawley; Risperidone; Scopolamine; Sulpiride; Thiazoles; Thioridazine | 2002 |
Effects of antipsychotic drugs on operant responding after acute and repeated administration.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Conditioning, Operant; Dibenzothiazepines; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Male; Olanzapine; Pirenzepine; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Remoxipride; Risperidone; Thioridazine; Time Factors | 2002 |
Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Dialysis Solutions; Dopamine Antagonists; Extracellular Space; Haloperidol; Hippocampus; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Microdialysis; Olanzapine; Piperazines; Pirenzepine; Rats; Rats, Wistar; Risperidone; Serotonin Antagonists; Thiazoles; Thioridazine | 2002 |
Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data.
Topics: Adult; Aged; Antipsychotic Agents; Arrhythmias, Cardiac; Clozapine; Cohort Studies; Confidence Intervals; Death, Sudden, Cardiac; Female; Haloperidol; Heart Arrest; Humans; Male; Medicaid; Middle Aged; Risperidone; Schizophrenia; Thioridazine; United States | 2002 |
Cutaneous drug reaction case reports: from the world literature.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Benzamides; Clozapine; Cyclosporine; Diclofenac; Drug Eruptions; Female; Humans; Imatinib Mesylate; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Nimodipine; Paroxetine; Piperazines; Polyethylene Glycols; Prednisolone; Pyrimidines; Recombinant Proteins; Salicylamides; Spironolactone; Thioridazine; Vinblastine; Vinorelbine | 2003 |
Atypical antipsychotic drugs and diabetes mellitus in a large outpatient population: a retrospective cohort study.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Clozapine; Cohort Studies; Databases, Factual; Diabetes Mellitus; Dibenzothiazepines; Drug Prescriptions; Female; Humans; Incidence; Insurance Claim Reporting; Male; Middle Aged; Multivariate Analysis; Olanzapine; Outpatients; Piperazines; Quetiapine Fumarate; Retrospective Studies; Risperidone; Sex Factors; Thiazoles; Thioridazine; Time Factors; United States | 2005 |
The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production.
Topics: Adrenal Glands; Animals; Antipsychotic Agents; Brain; Cell Line; Clozapine; Corticosterone; Humans; Isoquinolines; Male; Mice; Mitochondria; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, GABA; Risperidone; Steroids; Sulpiride; Testis; Testosterone; Thioridazine | 2008 |
Evaluation of five antischizophrenic agents against Toxoplasma gondii in human cell cultures.
Topics: Antipsychotic Agents; Cell Line; Clozapine; Fibroblasts; Fluphenazine; Haloperidol; Humans; Schizophrenia; Thioridazine; Toxoplasma; Toxoplasmosis; Trifluoperazine | 2011 |
Higher serum concentrations of tyrosine and glutamate in schizophrenia patients treated with clozapine, compared to in those treated with conventional antipsychotics.
Topics: Adult; Amino Acids; Antipsychotic Agents; Chromatography, Ion Exchange; Clopenthixol; Clozapine; Cohort Studies; Female; Glutamic Acid; Haloperidol; Humans; Insulin Resistance; Male; Middle Aged; Perphenazine; Prospective Studies; Psychotic Disorders; Schizophrenia; Thioridazine; Tyrosine | 2015 |
Rapid determination of some psychotropic drugs in complex matrices by tandem dispersive liquid-liquid microextraction followed by high performance liquid chromatography.
Topics: Chlorpromazine; Chromatography, High Pressure Liquid; Clozapine; Humans; Limit of Detection; Liquid Phase Microextraction; Psychotropic Drugs; Thioridazine; Time Factors; Wastewater | 2017 |