Page last updated: 2024-08-18

thiophenes and thiolactomycin

thiophenes has been researched along with thiolactomycin in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (12.35)	18.7374
1990's	14 (17.28)	18.2507
2000's	44 (54.32)	29.6817
2010's	13 (16.05)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gotoh, M; Hayashi, H; Morita, N; Okajima, N; Okuyama, H; Sasaki, S	1
Jackowski, S; Rock, CO; Tsay, JT	1
Fujiwara, T; Hamada, S; Koga, T; Matsuno, T; Nehashi, T; Nishihara, T; Ogawa, T; Shimauchi, H	1
Cunningham, ML; Matthews, HB	1
Ando, K; Iitaka, Y; Nawata, Y; Oishi, H; Sasaki, H; Sawada, M; Suzuki, K	1
Cronan, JE; Jackowski, S; Murphy, CM; Rock, CO	1
Abe, K; Iwanami, M; Kadota, S; Sato, T; Suzuki, K; Takamura, S	1
Kawaguchi, A; Nishida, I; Yamada, M	1
Hayashi, T; Kawaguchi, A; Okazaki, H; Sasaki, H; Yamamoto, O	2
Endo, H; Miyakawa, S; Noto, T; Oishi, H; Okazaki, H	1
Ando, K; Hayashi, T; Noto, T; Oishi, H; Okazaki, H; Sasaki, H; Sawada, M; Suzuki, K	1
Ando, K; Hayashi, T; Matsuura, I; Oishi, H; Sasaki, H; Sawada, M	1
Harada, Y; Miyakawa, S; Noto, T; Okazaki, H; Suzuki, K	1
Lewis, K; Lomovskaya, O; Matin, A	1
Dancer, JE; Harwood, JL; Jones, AL	2
Gulliver, BS; Slabas, AR	1
Arimura, N; Kaneda, T	1
Furukawa, H; Jackowski, S; Rock, CO; Takamura, Y; Tsay, JT	1
Armour, JW; Besra, GS; Brennan, PJ; Cooper, AM; Lee, RE; Orme, IM; Slayden, RA	1
Han, L; Lobo, S; McArthur, HA; Reynolds, KA; Wallace, KK	1
Schweizer, HP	1
Han, L; Lobo, S; Reynolds, KA	1
Keithly, JS; Marchewka, MJ; Upton, SJ; Woods, KM; Zhu, G	1
Dancer, JE; Harwood, JL; Herbert, D; Jones, AL; Rutter, AJ	1
Alland, D; Baulard, AR; Besra, GS; Brennan, PJ; Douglas, JD; Dover, LG; Guy, MR; Jacobs, WR; Kremer, L; Lakey, JH; Minnikin, DE; Morehouse, C	1
Englund, PT; Morita, YS; Paul, KS	1
He, X; Mueller, JP; Reynolds, KA	1
Choi, KH; Heath, RJ; Li, Z; Price, AC; Rock, CO; White, SW	1
Barry, CE; Lee, RE; Slayden, RA	1
Dick, JD; Houston, T; Jones, PB; Parrish, NM; Townsend, C	1
Brandt, M; Chambers, PA; Daines, RA; Doyle, ML; Gentry, DR; Khandekar, SS; Konstantinidis, AK; Lonsdale, JT; Silverman, C; Van Aller, GS; Warren, P; Xiang, H	1
Florova, G; Lobo, S; Reynolds, KA	1
Dirlam, JP; George, DM; Hayashi, SF; Kamicker, BJ; O'Connell, TN; Sakya, SM; Santoro, SL; Suarez-Contreras, M; Ziegler, CB	1
Agnihotri, G; Brennan, PJ; Kallender, H; Lonsdale, JT; Schaeffer, ML; Volker, C	1
Jackowski, S; Price, AC; Rock, CO; White, SW; Zhang, YM	1
He, X; Reynolds, KA	1
Besra, GS; Campbell, IB; Douglas, JD; Minnikin, DE; Morehouse, C; Phetsukiri, B; Senior, SJ	1
Barry, CE; Slayden, RA	1
Besra, GS; Cowman, AF; Douglas, JD; McFadden, GI; Minnikin, DE; Ralph, SA; Reed, MB; Su, V; Waller, RF	1
Gerena, L; He, X; Prigge, ST; Reynolds, KA; Waters, NC	1
Daines, RA; Khandekar, SS; Lonsdale, JT	1
Frehywot, GL; McFadden, JM; Townsend, CA	1
Dancer, JE; Gane, AM; Harwood, JL; Herbert, D; Jones, AL; Kille, P; Rutter, AJ; Willey, DL	1
Akopiants, K; Brown, MS; McArthur, HA; McCormick, E; Resceck, DM; Reynolds, KA	1
Betts, JC; Blakemore, SJ; Duncan, K; Kelly, FM; Lennon, MG; Lukey, PT; McLaren, A	1
Besra, GS; Campbell, IB; Gurcha, SS; Illarionov, PA; Minnikin, DE; Schaeffer, ML; Senior, SJ	2
Berry, C; Brun, R; Gilbert, IH; Harwood, JL; Jones, SM; Urch, JE	1
Desai, UR; He, X; Kellogg, GE; Reeve, AM; Reynolds, KA	1
Carson, JD; Kallender, H; Lonsdale, JT; Schaeffer, ML	1
Kuhajda, FP; McFadden, JM; Medghalchi, SM; Miller, KI; Pinn, ML; Thupari, JN; Townsend, CA; Vadlamudi, A	1
Arora, SK; Kamal, A; Shaik, AA; Sinha, R; Yadav, JS	1
Berry, C; Brun, R; Gilbert, IH; Harwood, JL; Jones, SM; Kaiser, M; Urch, JE	1
Culhane, JM; Witczak, ZJ	1
Sato, S; Wilson, RJ	1
Barry, CE; Boshoff, HI; Dowd, CS; Duncan, K; Goodwin, MB; Kim, P; Lonsdale, J; Manjunatha, UH; Miller, DJ; Nguyen, QA; Price, AC; Rock, CO; Shenoy, G; White, SW; Zhang, YM	1
Basilio, A; Collado, J; Galgoci, A; Kodali, S; Ondeyka, JG; Painter, R; Singh, SB; Tormo, JR; Vicente, F; Wang, J; Young, K; Zink, DL	1
Besra, GS; Brown, AK; Dover, LG; Kremer, L; Sacchettini, JC; Sridharan, S; Wang, L	1
Brückner, R; Dormann, KL	1
Besra, GS; Bhowruth, V; Brown, AK; Senior, SJ; Snaith, JS	1
Grininger, M; Johansson, P; Kessler, B; Kumari, P; Oesterhelt, D; Vonck, J; Vonrhein, C; Wiltschi, B	1
Ohata, K; Terashima, S	2
Azeeza, S; Kamal, A; Malik, MS; Rao, MV; Shaik, AA	1
Kisker, C; Luckner, SR; Machutta, CA; Tonge, PJ	1
Atella, GC; de Souza, W; Gilbert, IH; Jones, SM; Martins-Duarte, ES; Vommaro, RC	1
Chen, Y; Lu, X; You, Q	1
Bommineni, GR; Kapilashrami, K; Kisker, C; Luckner, SR; Machutta, CA; Ruzsicska, B; Simmerling, C; Tonge, PJ	1
Furuchi, T; Hanai, T; Hirono, S; Homma, H; Katane, M; Koyama, N; Nakagome, I; Saitoh, Y; Sekine, M; Tomoda, H	1
Bhunia, SS; Roy, KK; Saxena, AK	1
Case, DA; Labahn, A; Steinbrecher, T	1
Bommineni, GR; Kapilashrami, K; Kim, P; Lai, CT; Machutta, CA; Picart, F; Simmerling, C; Tonge, PJ	1
Berakdar, N; Sabbagh, G	1
Jensen, PR; Li, J; Mantovani, SM; Millán-Aguiñaga, N; Moore, BS; O'Neill, EC; Tang, X; Ugalde, JA; Zhang, JJ	1
Bommineni, GR; Cummings, JE; Gu, C; Kapilashrami, K; Knudson, SE; Lu, Y; Slayden, RA; Tonge, PJ; Walker, SG	1
Jenkins, R; Leadlay, PF; Sun, Y; Tosin, M; Yurkovich, ME	1
Li, J; Moore, BS; Tang, X	1
Durairaj, DR; Shanmughavel, P	1
Moore, BS; Tang, X; Zhang, JJ	1

Reviews

4 review(s) available for thiophenes and thiolactomycin

Article	Year
Bacterial beta-ketoacyl-acyl carrier protein synthases as targets for antibacterial agents. Current protein & peptide science, 2003, Volume: 4, Issue:1 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Cerulenin; Enzyme Inhibitors; Indoles; Thiophenes	2003
Thiosugars: new perspectives regarding availability and potential biochemical and medicinal applications. Applied microbiology and biotechnology, 2005, Volume: 69, Issue:3 Topics: Carbohydrate Conformation; Dicarboxylic Acids; Monosaccharides; Organophosphorus Compounds; Sugar Alcohols; Sulfates; Thioglycosides; Thiophenes	2005
The plastid of Plasmodium spp.: a target for inhibitors. Current topics in microbiology and immunology, 2005, Volume: 295 Topics: Animals; Antimalarials; Clindamycin; Doxycycline; Drug Therapy, Combination; Fatty Acids; Fosfomycin; Plasmodium; Plastids; Thiophenes; Triclosan	2005
Efforts towards the development of new antitubercular agents: potential for thiolactomycin based compounds. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2008, Sep-09, Volume: 11, Issue:2 Topics: Animals; Antitubercular Agents; Drug Design; Ethambutol; Isoniazid; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Physiological Phenomena; Pyrazinamide; Rifamycins; Streptomycin; Thiophenes; Tuberculosis; Tuberculosis, Pulmonary	2008

Other Studies

77 other study(ies) available for thiophenes and thiolactomycin

Article	Year
Synthesis in vitro of very long chain fatty acids in Vibrio sp. strain ABE-1. Archives of microbiology, 1992, Volume: 157, Issue:3 Topics: Acyl Carrier Protein; Acyl Coenzyme A; Anti-Bacterial Agents; Esters; Fatty Acid Synthases; Fatty Acids; Malonyl Coenzyme A; Thiophenes; Vibrio	1992
Overproduction of beta-ketoacyl-acyl carrier protein synthase I imparts thiolactomycin resistance to Escherichia coli K-12. Journal of bacteriology, 1992, Volume: 174, Issue:2 Topics: Acyltransferases; Carrier Proteins; Drug Resistance, Microbial; Escherichia coli; Fatty Acid Synthases; Fatty Acids, Unsaturated; Thiophenes	1992
Antimicrobial activities of thiolactomycin against gram-negative anaerobes associated with periodontal disease. f1. Oral microbiology and immunology, 1990, Volume: 5, Issue:6 Topics: Actinobacillus; Actinomyces; Anti-Bacterial Agents; Bacteroides; Eikenella corrodens; Gram-Negative Anaerobic Bacteria; Microbial Sensitivity Tests; Periodontal Diseases; Thiophenes	1990
Evidence for an acetoxyarylamine as the ultimate mutagenic reactive intermediate of the carcinogenic aromatic amine 2,4-diaminotoluene. Mutation research, 1990, Volume: 242, Issue:2 Topics: Acetylation; Acetyltransferases; Animals; Biotransformation; Cells, Cultured; Liver; Male; Mutagenicity Tests; Mutagens; Phenylenediamines; Pyridines; Rats; Rats, Inbred F344; Thiophenes; Toluidines	1990
Structure of thiolactomycin. Acta crystallographica. Section C, Crystal structure communications, 1989, Jun-15, Volume: 45 ( Pt 6) Topics: Anti-Bacterial Agents; Crystallography; Molecular Structure; Thiophenes	1989
Acetoacetyl-acyl carrier protein synthase. A target for the antibiotic thiolactomycin. The Journal of biological chemistry, 1989, May-05, Volume: 264, Issue:13 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyl Coenzyme A; Acyl Carrier Protein; Acyltransferases; Drug Resistance, Microbial; Escherichia coli; Fatty Acids; Kinetics; Lactones; Malonyl Coenzyme A; Thiophenes	1989
834-B1, a new thiolactone containing antibiotic taxonomy, fermentation, isolation and structure. The Journal of antibiotics, 1989, Volume: 42, Issue:6 Topics: Anti-Bacterial Agents; Chromatography, Gel; Culture Media; Fermentation; Lactones; Molecular Structure; Streptomyces; Thiophenes	1989
Effect of thiolactomycin on the individual enzymes of the fatty acid synthase system in Escherichia coli. Journal of biochemistry, 1986, Volume: 99, Issue:5 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Acyl-Carrier Protein S-Acetyltransferase; Anti-Bacterial Agents; Cerulenin; Escherichia coli; Fatty Acid Synthases; Lactones; Thiophenes	1986
Mechanism of action of the antibiotic thiolactomycin inhibition of fatty acid synthesis of Escherichia coli. Biochemical and biophysical research communications, 1983, Sep-30, Volume: 115, Issue:3 Topics: Acetates; Animals; Anti-Bacterial Agents; Candida albicans; Cerulenin; Escherichia coli; Fatty Acid Synthases; Fatty Acids; Kinetics; Lactones; Liver; Rats; Saccharomyces cerevisiae; Species Specificity; Structure-Activity Relationship; Thiophenes	1983
Inhibition of fatty acid synthesis by the antibiotic thiolactomycin. The Journal of antibiotics, 1984, Volume: 37, Issue:11 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Proteins; Fatty Acid Synthases; Fatty Acids; Lactones; Nucleic Acids; Thiophenes	1984
Thiolactomycin, a new antibiotic. III. In vitro antibacterial activity. The Journal of antibiotics, 1982, Volume: 35, Issue:4 Topics: Anti-Bacterial Agents; Bacteria; beta-Lactamase Inhibitors; Lactones; Microbial Sensitivity Tests; Thiophenes	1982
Thiolactomycin, a new antibiotic. I. Taxonomy of the producing organism, fermentation and biological properties. The Journal of antibiotics, 1982, Volume: 35, Issue:4 Topics: Anti-Bacterial Agents; Fermentation; Lactones; Nocardia; Thiophenes	1982
Thiolactomycin, a new antibiotic. II. Structure elucidation. The Journal of antibiotics, 1982, Volume: 35, Issue:4 Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Lactones; Magnetic Resonance Spectroscopy; Thiophenes	1982
Thiolactomycin, a new antibiotic. IV. Biological properties and chemotherapeutic activity in mice. The Journal of antibiotics, 1982, Volume: 35, Issue:4 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Female; Lactones; Male; Mice; Mice, Inbred Strains; Pyelonephritis; Rats; Rats, Inbred Strains; Thiophenes; Tissue Distribution	1982
EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB. Journal of bacteriology, 1995, Volume: 177, Issue:9 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Biological Transport; Drug Resistance; Drug Resistance, Microbial; Drug Resistance, Multiple; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Regulator; Ion Pumps; Membrane Proteins; Molecular Sequence Data; Operon; Promoter Regions, Genetic; Repressor Proteins; Sequence Homology, Amino Acid; Terminator Regions, Genetic; Thiophenes; Transcription Factors	1995
The effect of thiolactomycin analogues on fatty acid synthesis in peas (Pisum sativum cv. Onward). Biochemical Society transactions, 1994, Volume: 22, Issue:3 Topics: Cerulenin; Fatty Acid Synthases; Fatty Acids; Pisum sativum; Structure-Activity Relationship; Thiophenes	1994
The effect of thiolactomycin on fatty acid synthesis in peas (Pisum sativum, cv Onward). Biochemical Society transactions, 1994, Volume: 22, Issue:2 Topics: Chloroplasts; Fatty Acid Synthases; Fatty Acids; Pisum sativum; Thiophenes	1994
Acetoacyl-acyl carrier protein synthase from avocado: its purification, characterisation and clear resolution from acetyl CoA:ACP transacylase. Plant molecular biology, 1994, Volume: 25, Issue:2 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyl Coenzyme A; Acetyltransferases; Acyl-Carrier Protein S-Acetyltransferase; Buffers; Cerulenin; Fruit; Hydrogen-Ion Concentration; Kinetics; Malonyl Coenzyme A; Molecular Weight; Thiophenes	1994
Type selective inhibition of microbial fatty acid synthases by thiolactomycin. Archives of microbiology, 1993, Volume: 160, Issue:2 Topics: Anti-Bacterial Agents; Bacillus; Bacillus subtilis; Escherichia coli; Fatty Acid Synthases; Thiophenes	1993
Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB. Journal of bacteriology, 1993, Volume: 175, Issue:12 Topics: Biological Transport; Cerulenin; Chromosome Mapping; Drug Resistance, Microbial; Escherichia coli; Fatty Acid Synthases; Genes, Bacterial; Malonyl Coenzyme A; Operon; Thiophenes	1993
Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:12 Topics: Anti-Bacterial Agents; Fatty Acid Synthases; Fatty Acids; Macrophages; Mycobacterium tuberculosis; Mycolic Acids; Thiophenes	1996
In vivo and in vitro effects of thiolactomycin on fatty acid biosynthesis in Streptomyces collinus. Journal of bacteriology, 1997, Volume: 179, Issue:12 Topics: Acetic Acid; Anti-Bacterial Agents; Butyrates; Butyric Acid; Fatty Acid Synthases; Fatty Acids; Isobutyrates; Palmitic Acid; Streptomyces; Thiophenes	1997
Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:2 Topics: Anti-Bacterial Agents; Cerulenin; Chromosomes, Bacterial; Drug Resistance, Microbial; Fatty Acids; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Thiophenes	1998
Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis. Journal of bacteriology, 1998, Volume: 180, Issue:17 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Base Sequence; Chromatography, Gel; DNA Primers; Enzyme Inhibitors; Fatty Acids; Hydrogen-Ion Concentration; Leucine; Streptomyces; Substrate Specificity; Thiophenes; Valine	1998
Molecular analysis of a Type I fatty acid synthase in Cryptosporidium parvum. Molecular and biochemical parasitology, 2000, Feb-05, Volume: 105, Issue:2 Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Cerulenin; Cryptosporidium parvum; Fatty Acid Synthases; Fluorescent Antibody Technique; Genes, Protozoan; Humans; Molecular Sequence Data; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thiophenes	2000
Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum). The Biochemical journal, 2000, Apr-01, Volume: 347 Pt 1 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Anti-Bacterial Agents; Chloroplasts; Enzyme Inhibitors; Escherichia coli; Kinetics; Pisum sativum; Plant Leaves; Structure-Activity Relationship; Thiophenes	2000
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis. The Journal of biological chemistry, 2000, Jun-02, Volume: 275, Issue:22 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; Alcohol Oxidoreductases; Antitubercular Agents; Isoenzymes; Mycobacterium tuberculosis; Mycolic Acids; Protein Conformation; Sequence Homology, Amino Acid; Thiophenes	2000
Specialized fatty acid synthesis in African trypanosomes: myristate for GPI anchors. Science (New York, N.Y.), 2000, Apr-07, Volume: 288, Issue:5463 Topics: Acyl Coenzyme A; Animals; Anti-Bacterial Agents; Caprylates; Cell-Free System; Cerulenin; Decanoic Acids; Fatty Acid Synthases; Fatty Acids; Glycosylphosphatidylinositols; Laurates; Myristates; Subcellular Fractions; Thiophenes; Trypanosoma brucei brucei	2000
Development of a scintillation proximity assay for beta-ketoacyl-acyl carrier protein synthase III. Analytical biochemistry, 2000, Jun-15, Volume: 282, Issue:1 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyl Coenzyme A; Acyl Carrier Protein; Anti-Bacterial Agents; Biotinylation; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Escherichia coli; Inhibitory Concentration 50; Iodoacetamide; Isoenzymes; Kinetics; Microspheres; Models, Biological; Protein Conformation; Scintillation Counting; Streptomyces; Thiophenes; Time Factors	2000
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. The Journal of biological chemistry, 2001, Mar-02, Volume: 276, Issue:9 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Binding Sites; Cerulenin; Enzyme Inhibitors; Isoenzymes; Structure-Activity Relationship; Thiophenes	2001
Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis. Molecular microbiology, 2000, Volume: 38, Issue:3 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antitubercular Agents; Bacterial Proteins; Drug Resistance, Microbial; Enzyme Inhibitors; Fatty Acid Synthase, Type II; Humans; Isoniazid; Lipids; Microbial Sensitivity Tests; Multienzyme Complexes; Mycobacterium smegmatis; Mycobacterium tuberculosis; Operon; Oxidoreductases; Thiophenes; Triclosan	2000
In vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesis. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:4 Topics: Acetamides; Alkanesulfonates; Anti-Bacterial Agents; Chromatography, Thin Layer; Membrane Lipids; Microbial Sensitivity Tests; Microscopy, Electron; Mycobacterium; Mycobacterium bovis; Mycobacterium smegmatis; Mycobacterium tuberculosis; Mycolic Acids; Thiophenes	2001
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH). The Journal of biological chemistry, 2001, Aug-10, Volume: 276, Issue:32 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Amino Acid Sequence; Anti-Bacterial Agents; Asparagine; Catalysis; Chromatography; Circular Dichroism; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Guanidine; Histidine; Indoles; Inhibitory Concentration 50; Isoelectric Focusing; Kinetics; Models, Chemical; Molecular Sequence Data; Sequence Homology, Amino Acid; Streptococcus pneumoniae; Substrate Specificity; Thiophenes; Ultraviolet Rays	2001
A Streptomyces collinus thiolase with novel acetyl-CoA:acyl carrier protein transacylase activity. Biochemistry, 2001, Oct-02, Volume: 40, Issue:39 Topics: Acetyl-CoA C-Acetyltransferase; Acetyltransferases; Acyl-Carrier Protein S-Acetyltransferase; Amino Acid Sequence; Base Sequence; Chromatography, Gel; Cloning, Molecular; DNA Primers; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Escherichia coli; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Open Reading Frames; Recombinant Proteins; Sequence Homology, Amino Acid; Streptomyces; Thiophenes	2001
Synthesis and structure-activity relationships of thiotetronic acid analogues of thiolactomycin. Bioorganic & medicinal chemistry letters, 2001, Oct-22, Volume: 11, Issue:20 Topics: Anti-Bacterial Agents; Microbial Sensitivity Tests; Staphylococcus aureus; Structure-Activity Relationship; Thiophenes	2001
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB. The Journal of biological chemistry, 2001, Dec-14, Volume: 276, Issue:50 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Anti-Bacterial Agents; Antifungal Agents; Bacterial Proteins; Carbon; Cerulenin; Chromatography, Affinity; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Escherichia coli; Fatty Acid Synthase, Type II; Fatty Acids; Gene Deletion; Inhibitory Concentration 50; Kinetics; Models, Chemical; Multienzyme Complexes; Mycobacterium tuberculosis; Mycolic Acids; Phylogeny; Protein Binding; Substrate Specificity; Thiophenes; Time Factors	2001
A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:5 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Isoenzymes; Microbial Sensitivity Tests; Models, Molecular; Mutation, Missense; Thiophenes	2002
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:5 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Amino Acid Sequence; Enzyme Inhibitors; Humans; Kinetics; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Sequence Data; Oligopeptides; Staphylococcal Infections; Staphylococcus aureus; Substrate Specificity; Sulfhydryl Compounds; Thiophenes	2002
Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity. Microbiology (Reading, England), 2002, Volume: 148, Issue:Pt 10 Topics: Acetyltransferases; Anti-Bacterial Agents; Bacterial Proteins; Fatty Acid Synthase, Type II; Fatty Acid Synthases; Microbial Sensitivity Tests; Multienzyme Complexes; Mycobacterium smegmatis; Mycobacterium tuberculosis; Mycolic Acids; Thiophenes	2002
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland), 2002, Volume: 82, Issue:4-5 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Antibiotics, Antitubercular; Cell-Free System; Culture Media; Drug Resistance, Bacterial; Fatty Acid Synthases; Isoniazid; Mutation; Mycobacterium smegmatis; Mycobacterium tuberculosis; Mycolic Acids; Substrate Specificity; Thiophenes; Triclosan	2002
A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:1 Topics: Animals; Fatty Acids; Plasmodium falciparum; Structure-Activity Relationship; Thiophenes	2003
The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. Biochemistry, 2003, Feb-04, Volume: 42, Issue:4 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acyl Carrier Protein; Amino Acid Sequence; Animals; Catalysis; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Synthases; Genetic Vectors; Malonyl Coenzyme A; Molecular Sequence Data; Plasmodium falciparum; Recombinant Fusion Proteins; Substrate Specificity; Thiophenes	2003
A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis. Organic letters, 2002, Oct-31, Volume: 4, Issue:22 Topics: Acetyltransferases; Alanine; Anti-Bacterial Agents; Fatty Acid Synthase, Type II; Fatty Acids; Humans; Multienzyme Complexes; Neoplasms; Obesity; Stereoisomerism; Thiophenes	2002
Beta-ketoacyl-acyl carrier protein synthase III from pea (Pisum sativum L.): properties, inhibition by a novel thiolactomycin analogue and isolation of a cDNA clone encoding the enzyme. Planta, 2003, Volume: 216, Issue:5 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Amino Acid Sequence; Cloning, Molecular; Coenzyme A-Transferases; DNA, Complementary; Molecular Sequence Data; Phylogeny; Pisum sativum; Protein Structure, Tertiary; Sequence Analysis, DNA; Thiophenes	2003
Biosynthetic origins of the natural product, thiolactomycin: a unique and selective inhibitor of type II dissociated fatty acid synthases. Journal of the American Chemical Society, 2003, Aug-27, Volume: 125, Issue:34 Topics: Acetyltransferases; Anti-Bacterial Agents; Enzyme Inhibitors; Fatty Acid Synthase, Type II; Fermentation; Multienzyme Complexes; Nocardia; Thiophenes	2003
Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:9 Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Antitubercular Agents; DNA, Complementary; Down-Regulation; Gene Expression Regulation, Bacterial; Isoniazid; Mycobacterium tuberculosis; Oligonucleotide Array Sequence Analysis; Operon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Bacterial; Thiophenes; Triclosan; Up-Regulation	2003
Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme. Bioorganic & medicinal chemistry letters, 2003, Nov-03, Volume: 13, Issue:21 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Alkylation; Anti-Bacterial Agents; Fatty Acid Synthase, Type II; Fatty Acid Synthases; Multienzyme Complexes; Mycobacterium tuberculosis; Mycolic Acids; Recombinant Proteins; Thiophenes	2003
Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme. Bioorganic & medicinal chemistry letters, 2004, Jan-19, Volume: 14, Issue:2 Topics: Acetylene; Acetyltransferases; Bacterial Proteins; Enzyme Inhibitors; Fatty Acid Synthase, Type II; Fatty Acid Synthases; Multienzyme Complexes; Mycobacterium tuberculosis; Thiophenes	2004
Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents. Bioorganic & medicinal chemistry, 2004, Feb-15, Volume: 12, Issue:4 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Animals; Antimalarials; Cells, Cultured; Erythrocytes; Escherichia coli; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Plasmodium falciparum; Protein Structure, Tertiary; Rats; Thiophenes; Trypanocidal Agents; Trypanosoma	2004
1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH). Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:8 Topics: Anti-Bacterial Agents; Bacteria; Databases, Factual; Escherichia coli; Ligands; Microbial Sensitivity Tests; Models, Molecular; Protein Synthesis Inhibitors; Spectrometry, Fluorescence; Staphylococcus aureus; Thiones; Thiophenes; Transferases (Other Substituted Phosphate Groups)	2004
Development of a scintillation proximity assay for the Mycobacterium tuberculosis KasA and KasB enzymes involved in mycolic acid biosynthesis. Tuberculosis (Edinburgh, Scotland), 2004, Volume: 84, Issue:6 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Anti-Bacterial Agents; Chemistry Techniques, Analytical; Dimethyl Sulfoxide; Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific); Enzyme Inhibitors; Mycobacterium tuberculosis; Mycolic Acids; Oxidoreductases; Staphylococcus aureus; Thiophenes; Time Factors	2004
Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase. Journal of medicinal chemistry, 2005, Feb-24, Volume: 48, Issue:4 Topics: Animals; Anti-Obesity Agents; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Drug Screening Assays, Antitumor; Fatty Acid Synthases; Humans; Mice; Mice, Inbred BALB C; Models, Molecular; Stereoisomerism; Structure-Activity Relationship; Thiophenes	2005
Antitubercular agents. Part 2: new thiolactomycin analogues active against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters, 2005, Apr-01, Volume: 15, Issue:7 Topics: Antitubercular Agents; Lactones; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Structure-Activity Relationship; Sulfhydryl Compounds; Thiophenes	2005
Analogues of thiolactomycin as potential antimalarial agents. Journal of medicinal chemistry, 2005, Sep-22, Volume: 48, Issue:19 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Acetyltransferases; Animals; Antimalarials; Cell Line; Fatty Acid Synthase, Type II; Isoenzymes; Multienzyme Complexes; Myoblasts; Plasmodium falciparum; Rats; Structure-Activity Relationship; Thiophenes; Trypanocidal Agents	2005
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli. Journal of medicinal chemistry, 2006, Jan-12, Volume: 49, Issue:1 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Butadienes; Cell Proliferation; Crystallography, X-Ray; Escherichia coli; Hemiterpenes; Ligands; Microbial Sensitivity Tests; Models, Molecular; Mycobacterium tuberculosis; Pentanes; Structure-Activity Relationship; Thiophenes	2006
Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy. Journal of natural products, 2006, Volume: 69, Issue:3 Topics: Acetyltransferases; Alkadienes; Anti-Bacterial Agents; Ascomycota; Fatty Acid Synthase, Type II; Fatty Acid Synthases; Fatty Acids; France; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Structure; Multienzyme Complexes; Staphylococcus aureus; Thiophenes	2006
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB). Journal of molecular biology, 2007, Feb-16, Volume: 366, Issue:2 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Models, Molecular; Molecular Sequence Data; Mycobacterium tuberculosis; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Structure-Activity Relationship; Thiophenes	2007
Variable synthesis of the optically active thiotetronic acid antibiotics thiolactomycin, thiotetromycin, and 834-B1. Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:7 Topics: Acids; Anti-Bacterial Agents; Thiophenes	2007
Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library. Bioorganic & medicinal chemistry letters, 2007, Oct-15, Volume: 17, Issue:20 Topics: Biomimetic Materials; Databases, Factual; Inhibitory Concentration 50; Molecular Structure; Mycobacterium; Structure-Activity Relationship; Thiophenes	2007
Inhibition of the fungal fatty acid synthase type I multienzyme complex. Proceedings of the National Academy of Sciences of the United States of America, 2008, Sep-02, Volume: 105, Issue:35 Topics: Adamantane; Aminobenzoates; Anilides; Cerulenin; Fatty Acid Synthases; Models, Molecular; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharomyces cerevisiae; Substrate Specificity; Thiophenes	2008
Synthesis and biological activity of enantiomeric pairs of 5-[(E)-cycloalk-2-enylidenemethyl]thiolactomycin congeners. Bioorganic & medicinal chemistry letters, 2008, Oct-15, Volume: 18, Issue:20 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cell Line; Chemistry, Pharmaceutical; Drug Design; Fatty Acid Synthases; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Models, Chemical; Molecular Conformation; Structure-Activity Relationship; Thiophenes	2008
Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin. Structure (London, England : 1993), 2009, Jul-15, Volume: 17, Issue:7 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Antitubercular Agents; Binding Sites; Cell Wall; Crystallography, X-Ray; Fatty Acids; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Mycobacterium tuberculosis; Mycolic Acids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Substrate Specificity; Thiophenes	2009
Thiolactomycin analogues as potential anti-Toxoplasma gondii agents. Parasitology international, 2009, Volume: 58, Issue:4 Topics: Animals; Fatty Acids; Glycerides; Inhibitory Concentration 50; Microscopy, Electron, Transmission; Parasitic Sensitivity Tests; Thiophenes; Toxoplasma	2009
Synthesis and biological activity of enantiomeric pairs of 5-(Alk-2-enyl)thiolactomycin and 5-[(E)-Cycloalk-2-enylidenemethyl]thiolactomycin congeners. Chemical & pharmaceutical bulletin, 2009, Volume: 57, Issue:9 Topics: Anti-Bacterial Agents; Fatty Acid Synthases; Fatty Acid Synthesis Inhibitors; Stereoisomerism; Structure-Activity Relationship; Thiophenes	2009
3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:2 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Animals; Anti-Bacterial Agents; Binding Sites; Computer Simulation; Crystallography, X-Ray; Humans; Models, Molecular; Molecular Conformation; Mycobacterium tuberculosis; Protein Binding; Quantitative Structure-Activity Relationship; Thiophenes; Tuberculosis; User-Computer Interface	2010
Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin. The Journal of biological chemistry, 2010, Feb-26, Volume: 285, Issue:9 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Enzyme Inhibitors; Escherichia coli; Kinetics; Mycobacterium tuberculosis; Protein Binding; Protein Conformation; Substrate Specificity; Thiophenes	2010
Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment. Biochimie, 2010, Volume: 92, Issue:10 Topics: Animals; Binding, Competitive; Catalytic Domain; D-Aspartate Oxidase; Enzyme Inhibitors; Mice; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Substrate Specificity; Thiophenes	2010
CoMFA, CoMSIA, and docking studies on thiolactone-class of potent anti-malarials: identification of essential structural features modulating anti-malarial activity. Chemical biology & drug design, 2011, Volume: 78, Issue:3 Topics: Antimalarials; Drug Design; Humans; Malaria, Falciparum; Models, Molecular; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Thiophenes	2011
Free energy calculations on the binding of novel thiolactomycin derivatives to E. coli fatty acid synthase I. Bioorganic & medicinal chemistry, 2012, Jun-01, Volume: 20, Issue:11 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Anti-Bacterial Agents; Drug Design; Enzyme Inhibitors; Escherichia coli Proteins; Isoenzymes; Ligands; Models, Molecular; Molecular Dynamics Simulation; Thermodynamics; Thiophenes	2012
Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy. The Journal of biological chemistry, 2013, Mar-01, Volume: 288, Issue:9 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Bacterial Proteins; Enzyme Inhibitors; Mycobacterium smegmatis; Mycobacterium tuberculosis; Protein Binding; Structure-Activity Relationship; Thiophenes	2013
Docking studies of flavonoid compounds as inhibitors of β-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli. Journal of molecular graphics & modelling, 2015, Volume: 61 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Amino Acid Motifs; Anti-Bacterial Agents; Cerulenin; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Genistein; High-Throughput Screening Assays; Isoenzymes; Molecular Docking Simulation; Molecular Sequence Data; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Quercetin; Structure-Activity Relationship; Thermodynamics; Thiophenes; User-Computer Interface	2015
Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. ACS chemical biology, 2015, Dec-18, Volume: 10, Issue:12 Topics: Anti-Bacterial Agents; Biosynthetic Pathways; Computational Biology; Gene Targeting; Genome, Bacterial; Hydroxybutyrates; Molecular Structure; Multigene Family; Streptomyces; Sulfhydryl Compounds; Thiophenes	2015
Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity. Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Animals; Anti-Bacterial Agents; Burkholderia pseudomallei; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Francisella tularensis; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Molecular Conformation; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiophenes; Yersinia pestis	2016
The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase. Chemical communications (Cambridge, England), 2017, Feb-09, Volume: 53, Issue:13 Topics: Actinomycetales; Anti-Bacterial Agents; Biosynthetic Pathways; Multigene Family; Polyketide Synthases; Recombinant Proteins; Thiophenes	2017
Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation. Chembiochem : a European journal of chemical biology, 2017, 06-19, Volume: 18, Issue:12 Topics: Anti-Bacterial Agents; Aquatic Organisms; Bacterial Proteins; Biosynthetic Pathways; Cloning, Molecular; Cyclization; Cytochrome P-450 Enzyme System; Escherichia coli; Gene Expression Regulation, Bacterial; Genetic Engineering; Micromonosporaceae; Multigene Family; Mutagenesis; Plasmids; Stereoisomerism; Streptomyces coelicolor; Thiophenes	2017
In Silico Drug Design of Thiolactomycin Derivatives Against Mtb-KasA Enzyme to Inhibit Multidrug Resistance of Mycobacterium tuberculosis. Interdisciplinary sciences, computational life sciences, 2019, Volume: 11, Issue:2 Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Computer Simulation; Drug Design; Drug Resistance, Multiple, Bacterial; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Mycobacterium tuberculosis; Principal Component Analysis; Reproducibility of Results; Thiophenes	2019
Engineering Salinispora tropica for heterologous expression of natural product biosynthetic gene clusters. Applied microbiology and biotechnology, 2018, Volume: 102, Issue:19 Topics: Actinobacteria; Attachment Sites, Microbiological; Biological Products; Biosynthetic Pathways; Micromonosporaceae; Multigene Family; Secondary Metabolism; Streptomyces; Streptomyces coelicolor; Thiophenes	2018