Page last updated: 2024-08-18

thiophenes and tamoxifen

thiophenes has been researched along with tamoxifen in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	28 (34.15)	18.7374
1990's	14 (17.07)	18.2507
2000's	28 (34.15)	29.6817
2010's	12 (14.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ballejo, G; Gong, Y; Murphy, LC; Murphy, LJ	1
Koga, M; Sutherland, RL	2
Hagino, Y; Kohno, K; Kuwano, M; Mizoguchi, H; Uchiumi, T	1
Braunsberg, H; Coldham, NG; Patel, K	1
Durani, N; Durani, S; Jain, R; Kapil, RS; Saeed, A; Sharma, AP	1
Durani, S; Kapil, RS; Saeed, A; Sharma, AP	1
Arnold, AP; Mathews, GA	1
Boundy, V; Komm, BS; Lyttle, CR; Sundstrom, SA; Xu, Q	1
Galman, MS; Lyttle, CR; Sundstrom, SA	1
Davidson, NE; Gelmann, EP; Kasid, A; Lippman, ME	1
Hölzel, F; May, FE; Westley, BR	1
Dickson, RB; Katz, D; Lippman, ME; Shima, TB; Thompson, EW; Wakeling, AE	1
Johnson, MD; Kastner, P; May, FE; Wakeling, AE; Westley, BR; Wiseman, LR	1
Katzenellenbogen, BS; Toney, TW	1
Giambiagi, N; Pasqualini, JR; Sumida, C	1
Crastes de Paulet, A; Cypriani, B; Descomps, B; Tabacik, C	1
Dey, SK; Huet, YM	1
Shimizu, S; Takeda, A	1
Bronzert, DA; Davidson, N; Lippman, M	1
Amara, JF; Dannies, PS	1
Amara, JF; Dannies, PS; Martinez-Campos, A	1
Donahoe, PK; Hutson, JM; MacLaughlin, DT	1
Campen, CA; Gorski, J; Jordan, VC	1
Bronzert, DA; Greene, GL; Lippman, ME	1
Jordan, VC	1
Green, LR; Newboult, E; Valcaccia, B; Wakeling, AE	1
Newboult, E; O'Connor, KM; Wakeling, AE	1
Valcaccia, B; Wakeling, AE	1
Gosden, B; Jordan, VC	2
Jordan, VC; Mueller, GC; Olsen, MR; Tate, AC; Van Oosbree, TR	1
Huff, KK; Lippman, ME; Scholl, SM	1
Keeping, HS; Lyttle, CR	1
Black, LJ; Goode, RL; Jones, CD	1
Black, LJ; Goode, RL	2
Borras, M; Bouhoute, A; Jin, L; Leclercq, G; Legros, N	1
Berthois, Y; Crastes de Paulet, A; Dussert, C; Martin, PM; Pons, M	1
Fei, P; Kong, AN; Matwyshyn, GA; Rushmore, TH	1
Henkin, J; Mazar, A; Rabbani, SA; Xing, RH	1
De Caterina, R; Genazzani, AR; Simoncini, T	1
Acharya, A; Lei, J; Neugarten, J; Silbiger, S	1
Diaugustine, RP; Hewitt, SC; Klotz, DM; Korach, KS	1
Galid, A; Kubista, E; Seifert, M	1
Ali, IU; Herbert, BS; Kopelovich, L; Passons, CM; Shay, JW; Wright, AC; Wright, WE	1
Neubauer, BL; Raghow, S; Steiner, MS	1
Bentrem, D; Dardes, RC; De Los Reyes, A; Jordan, VC; Lee, ES; O'Regan, RM; Schafer, JM	1
Bryant, HU; Burris, LL; Glasebrook, AL; Palkowitz, AD; Pearce, HL; Peer, C; Sporn, MB; Starling, JJ; Suh, N; Wang, Y; Williams, C	1
Bentrem, D; Dardes, RC; Jordan, VC; O'Regan, RM; Schafer, JM	1
Fabian, CJ; Kimler, BF	1
Gajdos, C; Jordan, VC	1
Chan, S	1
Cox, DA; Hurn, PD; Littleton-Kearney, MT; Ostrowski, NL; Rossberg, MI	1
Booser, DJ; Buzdar, A; Hudis, C; Jones, SE; Melemed, AS; Munster, PN; O'Shaughnessy, JA; Peterson, P; Pippen, JE; Winer, E	1
Licun, W; Tannock, IF	1
A'Hern, R; Detre, S; Dowsett, M; Johnston, SR; Riddler, S; Salter, J	1
Balaguer, P; Bonnet, S; Cavaillès, V; Duong, V; Escande, A; Margueron, R; Vignon, F	1
Barone, G; Bollati, A; Bonfanti, C; Burattin, A; Cozzi, R; Giustina, A; Poiesi, C; Tulipano, G; Turazzi, S; Valle, D	1
Bartholomaeussen, M; Freddie, CT; Larsen, SS; Lykkesfeldt, AE	1
Christensen, GL; Freddie, CT; Lykkesfeldt, AE	1
Levine, L	1
Body, JJ; Journé, F; Laurent, G; Leclercq, G; Nonclercq, D	1
Johansen, AM	1
Chin, WW; Dantzig, AH; Iversen, PW; Jin, S; Krishnan, V; Lesoon, A; Moore, RE; O'Brien, KA; Peek, VL; Perry, WL; Rolfe, M; Sampath, J; Shepard, RL; Shyjan, A; Tighe, M; Williamson, M; Yaden, B	1
Benjamins, JA; Deighton-Collins, S; Guzmán, CB; Kleerekoper, M; Martinez, A; Skafar, DF; Zhao, C	1
Clarke, R; Dai, P; Lou, MA; Lu, JF; Nazarov, V; Wong, LJ	1
Cooperwood, JS; Khan, MO; Musa, MA	1
Buzdar, AU; Deshmane, V; Krishnamurthy, S; Melemed, AS; Peterson, P	1
Lewiecki, EM	1
Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H	1
Chines, AA; Komm, BS	1
Cuzick, J; Sestak, I	1
Liu, L; Lv, F; Wang, B; Wang, S; Yang, Q; Yuan, H; Zhu, C	1
Calaf Alsina, J; Coronado Martín, PJ	1
Bolton, JL; Chandrasena, RE; Choi, J; Hemachandra, LP; Michalsen, BT; Patel, H; Piyankarage, SC; Scism, RA; Siklos, MI; Thatcher, GR; Thayer, EN; Wang, S; Wang, Y; Xiong, R	1
Gherezghiher, T; Jordan, VC; Maximov, PY; Michalsen, BT; Molloy, ME; Patel, H; Thatcher, GR; Tonetti, DA; White, BE; Xiong, R; Zhao, H	1
Bambakidis, NC; Barnett, A; Filichia, E; Jin, Y; Luo, Y; Raviv, N	1
Fan, N; Huang, T; Meng, Q; Ming, J; Ruan, S; Tian, B; Wang, M; Ye, D	1
Briarava, M; Mocellin, S; Nitti, D; Pilati, P	1
Burdette, JE; Davis, DA; Dean, M; Moyle-Heyrman, G; Schipma, MJ	1
Cherkasov, A; Dalal, K; Lallous, N; Munuganti, RSN; Rennie, PS; Sharma, A; Singh, K; Yamazaki, T; Yoon, JS	1

Reviews

14 review(s) available for thiophenes and tamoxifen

Article	Year
Pharmacodynamic and biological effects of anti-estrogens in different models. Journal of steroid biochemistry, 1988, Volume: 31, Issue:4B Topics: Animals; Antibodies, Monoclonal; Cell Division; Clomiphene; DNA-Binding Proteins; Estradiol; Estrogen Antagonists; Female; Growth Substances; Humans; Lipoproteins, LDL; Liver; Nafoxidine; Nitromifene; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Species Specificity; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1988
Estrogen and antiestrogen resistance in human breast cancer cell lines. Advances in experimental medicine and biology, 1986, Volume: 196 Topics: Breast Neoplasms; Cell Division; Cell Line; Diethylstilbestrol; Drug Resistance; Estradiol; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Humans; Molecular Weight; Pyrrolidines; Tamoxifen; Thiophenes; Time Factors	1986
Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications. Breast cancer research and treatment, 1983, Volume: 3 Suppl Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Half-Life; Humans; Mammary Neoplasms, Experimental; Models, Biological; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Thiophenes	1983
Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. Annals of the New York Academy of Sciences, 2001, Volume: 952 Topics: Aneuploidy; Angiogenesis Inhibitors; Anticarcinogenic Agents; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Carcinoma in Situ; Clinical Trials, Phase II as Topic; Cyclooxygenase Inhibitors; Disease Progression; Eflornithine; Endpoint Determination; Enzyme Inhibitors; Estrogens; Female; Fenretinide; Gonadotropin-Releasing Hormone; Humans; Hyperplasia; Isoflavones; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phenotype; Piperidines; Polyamines; Precancerous Conditions; Protein-Tyrosine Kinases; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Uterine Neoplasms	2001
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade. Clinical breast cancer, 2002, Volume: 2, Issue:4 Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cinnamates; Drug Design; Forecasting; Humans; Molecular Biology; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Toremifene; Treatment Outcome	2002
A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer. Seminars in oncology, 2002, Volume: 29, Issue:3 Suppl 11 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Endometrial Neoplasms; Estradiol; Female; Fulvestrant; Humans; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2002
Selective estrogen receptor modulators: tissue actions and potential for CNS protection. CNS drug reviews, 2002,Fall, Volume: 8, Issue:3 Topics: Animals; Breast Neoplasms; Cardiovascular System; Central Nervous System; Cognition; Estrogen Antagonists; Estrogen Receptor Modulators; Female; Hormone Replacement Therapy; Humans; Hypothalamo-Hypophyseal System; Male; Neuroprotective Agents; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Receptors, Neurotransmitter; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	2002
Breast cancer chemoprevention: a review of selective estrogen receptor modulators. Clinical journal of oncology nursing, 2005, Volume: 9, Issue:3 Topics: Breast Neoplasms; Female; Humans; Piperidines; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2005
Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs). Current medicinal chemistry, 2007, Volume: 14, Issue:11 Topics: Breast Neoplasms; Drug Design; Estrogen Receptor alpha; Female; Humans; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Stilbenes; Structure-Activity Relationship; Tamoxifen; Thiophenes; Toremifene	2007
Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis. Journal of women's health (2002), 2009, Volume: 18, Issue:10 Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bone Density Conservation Agents; Denosumab; Drug Therapy, Combination; Female; Humans; Indoles; Middle Aged; Osteoporosis, Postmenopausal; Parathyroid Hormone; Piperidines; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; RANK Ligand; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Vitamin D; Women's Health	2009
Preventive therapy for breast cancer: a consensus statement. The Lancet. Oncology, 2011, Volume: 12, Issue:5 Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles	2011
An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis. Maturitas, 2012, Volume: 71, Issue:3 Topics: Bone Density Conservation Agents; Breast; Endometrium; Female; Fractures, Bone; Humans; Indoles; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes	2012
[Third generation selective estrogen receptor modulators: benefits beyond bone. II, endometrial action]. Medicina clinica, 2013, Mar-16, Volume: 140, Issue:6 Topics: Adenocarcinoma; Animals; Breast Neoplasms; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation, Preclinical; Endometrial Neoplasms; Endometrium; Estradiol; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Hot Flashes; Humans; Indoles; Menopause; Multicenter Studies as Topic; Organ Specificity; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Rats; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Thromboembolism	2013
Breast Cancer Chemoprevention: A Network Meta-Analysis of Randomized Controlled Trials. Journal of the National Cancer Institute, 2016, Volume: 108, Issue:2 Topics: Adult; Aged; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Middle Aged; Norpregnenes; Piperidines; Postmenopause; Primary Prevention; Pyrrolidines; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes	2016

Trials

2 trial(s) available for thiophenes and tamoxifen

Article	Year
Phase II, randomized, double-blind study of two dose levels of arzoxifene in patients with locally advanced or metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Neoplasm; Endometrium; Estrogen Receptor Modulators; Female; Humans; Middle Aged; Patient Selection; Piperidines; Receptors, Estrogen; Survival Analysis; Tamoxifen; Thiophenes; Treatment Outcome	2003
Phase III double-blind trial of arzoxifene compared with tamoxifen for locally advanced or metastatic breast cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Nov-01, Volume: 25, Issue:31 Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Double-Blind Method; Female; Humans; Piperidines; Postmenopause; Receptors, Steroid; Survival Analysis; Tamoxifen; Thiophenes; Time Factors; Treatment Failure	2007

Article

Year

Phase II, randomized, double-blind study of two dose levels of arzoxifene in patients with locally advanced or metastatic breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Neoplasm; Endometrium; Estrogen Receptor Modulators; Female; Humans; Middle Aged; Patient Selection; Piperidines; Receptors, Estrogen; Survival Analysis; Tamoxifen; Thiophenes; Treatment Outcome

2003

Phase III double-blind trial of arzoxifene compared with tamoxifen for locally advanced or metastatic breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Nov-01, Volume: 25, Issue:31

Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Double-Blind Method; Female; Humans; Piperidines; Postmenopause; Receptors, Steroid; Survival Analysis; Tamoxifen; Thiophenes; Time Factors; Treatment Failure

2007

Other Studies

66 other study(ies) available for thiophenes and tamoxifen

Article	Year
Differential effects of estrogen and antiestrogen on transforming growth factor gene expression in endometrial adenocarcinoma cells. Cancer research, 1992, Apr-01, Volume: 52, Issue:7 Topics: Adenocarcinoma; Analysis of Variance; Cell Division; Cell Line; Dose-Response Relationship, Drug; Endometrial Neoplasms; ErbB Receptors; Estradiol; Estrogen Antagonists; Female; Gene Expression; Humans; Kinetics; Polyunsaturated Alkamides; Pyrrolidines; RNA, Messenger; Tamoxifen; Thiophenes; Transforming Growth Factor alpha; Tumor Cells, Cultured	1992
Retinoic acid acts synergistically with 1,25-dihydroxyvitamin D3 or antioestrogen to inhibit T-47D human breast cancer cell proliferation. The Journal of steroid biochemistry and molecular biology, 1991, Volume: 39, Issue:4A Topics: Breast Neoplasms; Calcitriol; Cell Division; Cell Line; Clomiphene; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Calcitriol; Receptors, Estradiol; Receptors, Steroid; Tamoxifen; Thiophenes; Tretinoin	1991
Counteraction of estradiol-induced activation of tissue-type plasminogen activator in a human breast cancer cell line by an anti-estrogen, LY117018. International journal of cancer, 1991, Jan-02, Volume: 47, Issue:1 Topics: Breast Neoplasms; Cell Division; Cell Line; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrogen Antagonists; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Pyrrolidines; Receptors, Estrogen; RNA; Tamoxifen; Thiophenes; Tissue Plasminogen Activator	1991
Hormone and cytotoxic drug responsiveness of cultured human breast cancer cells resistant to specific hormones. International journal of cancer, 1990, Apr-15, Volume: 45, Issue:4 Topics: Breast Neoplasms; Cell Division; Dexamethasone; Drug Resistance; Estradiol; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Methotrexate; Pyrrolidines; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Vincristine	1990
Structure-activity relationship of antiestrogens. Studies on 2,3-diaryl-1-benzopyrans. Journal of medicinal chemistry, 1990, Volume: 33, Issue:12 Topics: Animals; Benzopyrans; Biological Assay; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Molecular Structure; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1990
Structure-activity relationship of antiestrogens. Effect of the side chain and its position on the activity of 2,3-diaryl-2H-1-benzopyrans. Journal of medicinal chemistry, 1990, Volume: 33, Issue:12 Topics: Animals; Benzopyrans; Binding, Competitive; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Mice; Microsomes, Liver; Molecular Structure; Organ Size; Piperidines; Pyrrolidines; Rats; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1990
Antiestrogens fail to prevent the masculine ontogeny of the zebra finch song system. General and comparative endocrinology, 1990, Volume: 80, Issue:1 Topics: Animals; Birds; Brain; Estrogen Antagonists; Female; Male; Pyrrolidines; Sex Differentiation; Stilbenes; Tamoxifen; Thiophenes; Vocalization, Animal	1990
The stimulation of uterine complement component C3 gene expression by antiestrogens. Endocrinology, 1990, Volume: 126, Issue:3 Topics: Animals; Complement C3; Drug Interactions; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation; Kinetics; Nucleic Acid Hybridization; Piperidines; Progesterone; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; RNA, Messenger; Tamoxifen; Thiophenes; Uterus	1990
Antagonism of estrogen- and antiestrogen-induced uterine complement component C3 expression by ICI 164,384. Journal of steroid biochemistry, 1990, Jul-04, Volume: 36, Issue:4 Topics: Animals; Complement C3; Epithelial Cells; Estradiol; Estrogen Antagonists; Female; Organ Size; Polyunsaturated Alkamides; Pyrrolidines; Rats; Rats, Inbred Strains; RNA, Messenger; Tamoxifen; Thiophenes; Uterus	1990
Transcriptional control of thymidine kinase gene expression by estrogen and antiestrogens in MCF-7 human breast cancer cells. The Journal of biological chemistry, 1986, Apr-25, Volume: 261, Issue:12 Topics: Amanitins; Breast Neoplasms; Cell Cycle; Cell Line; DNA; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation; Humans; Methylation; Pyrrolidines; RNA; RNA, Messenger; Tamoxifen; Thiophenes; Thymidine; Thymidine Kinase; Time Factors	1986
Effects of oestrogen and the antioestrogens, tamoxifen and LY117018, on four oestrogen-regulated RNAs in the EFM-19 breast cancer cell line. Journal of steroid biochemistry, 1989, Volume: 32, Issue:3 Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Gene Expression Regulation; Humans; Nucleic Acid Hybridization; Pyrrolidines; Receptors, Estrogen; RNA; RNA, Messenger; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1989
ICI 164,384, a pure antagonist of estrogen-stimulated MCF-7 cell proliferation and invasiveness. Cancer research, 1989, Dec-15, Volume: 49, Issue:24 Pt 1 Topics: Basement Membrane; Binding, Competitive; Breast Neoplasms; Cell Cycle; Estradiol; Estrogen Antagonists; Humans; Neoplasm Invasiveness; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Estrogen; Stimulation, Chemical; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1989
Regulation of progesterone receptor mRNA by oestradiol and antioestrogens in breast cancer cell lines. Journal of steroid biochemistry, 1989, Volume: 33, Issue:6 Topics: Animals; Autoradiography; Blotting, Northern; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrogen Antagonists; Mammary Neoplasms, Experimental; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Progesterone; RNA, Messenger; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1989
An evaluation of the interactions of antiestrogens with pituitary and striatal dopamine receptors. Journal of receptor research, 1987, Volume: 7, Issue:5 Topics: Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Diethylamines; Estrogen Antagonists; Female; Nitromifene; Pituitary Gland, Anterior; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tamoxifen; Thiophenes	1987
Role of estrogen receptors and antiestrogen binding sites in an early effect of antiestrogens, the inhibition of cholesterol biosynthesis. Journal of steroid biochemistry, 1988, Volume: 31, Issue:5 Topics: Animals; Binding Sites; Cell Division; Cell Line; Cholesterol; Humans; Molecular Weight; Pyrrolidines; Rats; Receptors, Drug; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1988
Role of early and late oestrogenic effects on implantation in the mouse. Journal of reproduction and fertility, 1987, Volume: 81, Issue:2 Topics: Animals; Clomiphene; Embryo Implantation; Embryo Implantation, Delayed; Estradiol; Estriol; Estrogens; Female; Mice; Mice, Inbred Strains; Nafoxidine; Nitromifene; Organ Size; Ovariectomy; Progesterone; Pyrrolidines; Tamoxifen; Thiophenes; Uterus	1987
Molecular effects of antiestrogens (tamoxifen and LY117018) on estrogen-dependent glycoprotein (USP-1) synthesized and secreted by rat uterine epithelial cells. Endocrinology, 1988, Volume: 123, Issue:1 Topics: Animals; Epithelium; Estradiol; Estrogen Antagonists; Female; Kinetics; Neoplasm Proteins; Ovariectomy; Pyrrolidines; Rats; Rats, Inbred Strains; Reference Values; Tamoxifen; Thiophenes; Uterus	1988
Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T 47D human breast cancer cell growth. Biochemical and biophysical research communications, 1987, Jul-31, Volume: 146, Issue:2 Topics: Breast Neoplasms; Cell Division; Cell Line; Clomiphene; Epidermal Growth Factor; Estrogen Antagonists; Humans; Pyrrolidines; Tamoxifen; Thiophenes	1987
Characterization of antiestrogen stimulation of cell number and prolactin production. Molecular and cellular endocrinology, 1986, Volume: 47, Issue:3 Topics: Cell Cycle; Cell Line; Estradiol; Pituitary Gland; Prolactin; Pyrrolidines; Tamoxifen; Thiophenes	1986
Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures. Molecular and cellular endocrinology, 1986, Volume: 48, Issue:2-3 Topics: Animals; Cells, Cultured; Estradiol; Estrogen Antagonists; Kinetics; Male; Pituitary Gland, Anterior; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Tamoxifen; Thiophenes	1986
Steroid modulation of Mullerian duct regression in the chick embryo. General and comparative endocrinology, 1985, Volume: 57, Issue:1 Topics: Aminoglutethimide; Androstenedione; Animals; Anti-Mullerian Hormone; Chick Embryo; Drug Interactions; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Growth Inhibitors; Male; Mullerian Ducts; Norethindrone; Pyrrolidines; Tamoxifen; Testicular Hormones; Thiophenes	1985
Opposing biological actions of antiestrogens in vitro and in vivo: induction of progesterone receptor in the rat and mouse uterus. Endocrinology, 1985, Volume: 116, Issue:6 Topics: Animals; Cells, Cultured; Estradiol; Estrogen Antagonists; Female; In Vitro Techniques; Mice; Mice, Inbred ICR; Pyrrolidines; Rats; Receptors, Progesterone; Species Specificity; Stereoisomerism; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1985
Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018. Endocrinology, 1985, Volume: 117, Issue:4 Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Drug Resistance; Estradiol; Female; Humans; Molecular Weight; Phenotype; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes	1985
Non-steroidal antioestrogens--receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. Journal of steroid biochemistry, 1984, Volume: 20, Issue:1 Topics: Animals; Breast Neoplasms; Cell Line; Estrogen Antagonists; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus	1984
Comparison of the biological effects of tamoxifen and a new antioestrogen (LY 117018) on the immature rat uterus. The Journal of endocrinology, 1983, Volume: 99, Issue:3 Topics: Animals; Estradiol; Estrogen Antagonists; Female; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Sexual Maturation; Tamoxifen; Thiophenes; Uterus	1983
Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens. The Journal of endocrinology, 1983, Volume: 99, Issue:3 Topics: Animals; Estradiol; Estrogen Antagonists; Female; Mammary Neoplasms, Experimental; Organ Size; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Tamoxifen; Thiophenes; Uterus	1983
Differential antiestrogen action in the immature rat uterus: a comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor. Journal of steroid biochemistry, 1983, Volume: 19, Issue:3 Topics: Animals; Binding, Competitive; Estrogen Antagonists; Female; Kinetics; Organ Size; Promegestone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Estrogen; Sexual Maturation; Tamoxifen; Thiophenes; Uterus	1983
An immobilized antiestrogen binds a specific uterine protein in addition to estrogen receptor proteins. Molecular and cellular endocrinology, 1984, Volume: 35, Issue:2-3 Topics: Agar; Animals; Carrier Proteins; Cytosol; Estrogen Antagonists; Female; Molecular Weight; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus	1984
Inhibition of the uterotropic activity of estrogens and antiestrogens by the short acting antiestrogen LY117018. Endocrinology, 1983, Volume: 113, Issue:2 Topics: Animals; Castration; Estradiol; Estrogen Antagonists; Female; Mice; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1983
Antiestrogenic effects of LY 117018 in MCF-7 cells. Endocrinology, 1983, Volume: 113, Issue:2 Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes	1983
Modulation of rat uterine progesterone receptor levels and peroxidase activity by tamoxifen citrate, LY117018, and estradiol. Endocrinology, 1982, Volume: 111, Issue:6 Topics: Animals; Cytosol; Estradiol; Female; Organ Size; Peroxidases; Progesterone; Promegestone; Pyrrolidines; Rats; Receptors, Progesterone; Tamoxifen; Thiophenes; Uterus	1982
Differential interaction of antiestrogens with cytosol estrogen receptors. Molecular and cellular endocrinology, 1981, Volume: 22, Issue:1 Topics: Animals; Binding, Competitive; Cytosol; Estradiol; Estrogen Antagonists; Female; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Temperature; Thiophenes; Uterus	1981
Evidence for biological action of the antiestrogens LY117018 and tamoxifen by different mechanisms. Endocrinology, 1981, Volume: 109, Issue:3 Topics: Animals; Castration; Estradiol; Estrogen Antagonists; Female; Pyrrolidines; Rats; Receptors, Estradiol; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1981
Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice. Life sciences, 1980, Apr-28, Volume: 26, Issue:17 Topics: Aging; Animals; Biological Assay; Castration; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Female; Mice; Pyrrolidines; Rats; Species Specificity; Tamoxifen; Thiophenes; Uterus	1980
Evaluation of estrogen receptor, antiestrogen binding sites and calmodulin for antiestrogen resistance of two clones derived from the MCF-7 breast cancer cell line. Biochemical pharmacology, 1994, Nov-29, Volume: 48, Issue:11 Topics: Binding Sites; Calmodulin; Cell Division; Clone Cells; Drug Resistance; Estrogen Antagonists; Humans; Imidazoles; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1994
Agonist-antagonist activity of anti-estrogens in the human breast cancer cell line MCF-7: an hypothesis for the interaction with a site distinct from the estrogen binding site. Molecular and cellular endocrinology, 1994, Volume: 99, Issue:2 Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Fractionation; Centrifugation, Density Gradient; Cytosol; Estradiol; Estrogen Antagonists; Humans; Pyrrolidines; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1994
Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents. Pharmaceutical research, 1996, Volume: 13, Issue:7 Topics: Anticarcinogenic Agents; Blotting, Northern; Chloramphenicol O-Acetyltransferase; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation; Genes, Reporter; Glutathione Transferase; Humans; Isothiocyanates; Liver; Pyrazines; Sulfoxides; Tamoxifen; Thiocyanates; Thiones; Thiophenes; Time Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured	1996
Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B-428. Cancer research, 1997, Aug-15, Volume: 57, Issue:16 Topics: Amidines; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Drug Screening Assays, Antitumor; Estrogen Antagonists; Female; Neoplasm Invasiveness; Rats; Rats, Inbred F344; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Tamoxifen; Thiophenes; Transcription, Genetic; Urokinase-Type Plasminogen Activator	1997
Selective estrogen receptor modulators: different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:2 Topics: Cells, Cultured; Endothelium, Vascular; Estradiol; Estrogen Antagonists; Gene Expression; Humans; Lipopolysaccharides; Pyrrolidines; Receptors, Estrogen; RNA, Messenger; Saphenous Vein; Tamoxifen; Thiophenes; Vascular Cell Adhesion Molecule-1	1999
Selective estrogen receptor modulators suppress mesangial cell collagen synthesis. American journal of physiology. Renal physiology, 2000, Volume: 279, Issue:2 Topics: Angiotensin II; Animals; Cell Line, Transformed; Collagen; Endothelin-1; Estrogen Receptor beta; Estrogens; Glomerular Mesangium; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Pyrrolidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transcription Factor AP-1; Transcription, Genetic; Transforming Growth Factor beta; Up-Regulation	2000
Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha. Endocrinology, 2000, Volume: 141, Issue:9 Topics: Animals; Benzhydryl Compounds; Blotting, Northern; Estradiol Congeners; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Estrogens, Non-Steroidal; Female; Insulin-Like Growth Factor I; Mice; Mice, Knockout; Mitosis; Ovariectomy; Phenols; Piperidines; Precipitin Tests; Proliferating Cell Nuclear Antigen; Receptors, Estrogen; Ribonucleases; RNA, Messenger; Signal Transduction; Tamoxifen; Thiophenes; Uterus	2000
The oestrogen receptor and its selective modulators in gynaecological oncology. European journal of cancer (Oxford, England : 1990), 2000, Volume: 36 Suppl 4 Topics: Antineoplastic Agents, Hormonal; Cinnamates; Estrogen Antagonists; Female; Genital Neoplasms, Female; Humans; Norpregnenes; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Thiophenes; Toremifene	2000
Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells. Journal of the National Cancer Institute, 2001, Jan-03, Volume: 93, Issue:1 Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Disease Progression; DNA, Complementary; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Li-Fraumeni Syndrome; Oligodeoxyribonucleotides, Antisense; Point Mutation; Pyrazines; Reverse Transcriptase Inhibitors; Tamoxifen; Telomerase; Thiones; Thiophenes; Transformation, Genetic; Tretinoin	2001
Selective estrogen receptor modulators for the chemoprevention of prostate cancer. Urology, 2001, Volume: 57, Issue:4 Suppl 1 Topics: Age Factors; Androgens; Anticarcinogenic Agents; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogens; Estrogens, Non-Steroidal; Humans; Isoflavones; Male; Phytoestrogens; Piperidines; Plant Preparations; Prostate; Prostatic Neoplasms; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2001
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:8 Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Mice; Mice, Nude; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2001
Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer. Cancer research, 2001, Dec-01, Volume: 61, Issue:23 Topics: Animals; Anticarcinogenic Agents; Binding, Competitive; Cell Division; Drug Interactions; Estradiol; Estradiol Congeners; Estrogen Antagonists; Ethinyl Estradiol; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Uterus	2001
Effects of the new selective estrogen receptor modulator LY353381.HCl (Arzoxifene) on human endometrial cancer growth in athymic mice. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:12 Topics: Animals; Cell Division; Down-Regulation; Endometrial Neoplasms; Estrogen Antagonists; Female; Humans; Mice; Mice, Nude; Piperidines; Receptors, Estrogen; Tamoxifen; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Selective estrogen receptor modulators as inhibitors of repopulation of human breast cancer cell lines after chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-01, Volume: 9, Issue:12 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Methotrexate; Neoplasms, Hormone-Dependent; Piperidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Tumor Stem Cell Assay	2003
Comparison of the selective estrogen receptor modulator arzoxifene (LY353381) with tamoxifen on tumor growth and biomarker expression in an MCF-7 human breast cancer xenograft model. Cancer research, 2003, Oct-01, Volume: 63, Issue:19 Topics: Animals; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Female; Humans; Mice; Mice, Nude; Piperidines; Protein Biosynthesis; Proteins; Receptors, Estrogen; Receptors, Progesterone; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Trefoil Factor-1; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays	2003
Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens. Journal of molecular endocrinology, 2004, Volume: 32, Issue:2 Topics: Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Fulvestrant; Genes, Reporter; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Pyrrolidines; Raloxifene Hydrochloride; Response Elements; Tamoxifen; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured	2004
Effects of the selective estrogen receptor modulator LY117018 on growth hormone secretion: In vitro studies. Metabolism: clinical and experimental, 2004, Volume: 53, Issue:5 Topics: Adenoma; Adult; Aged; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Male; Middle Aged; Pituitary Gland; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Secretory Rate; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2004
The effect of the new SERM arzoxifene on growth and gene expression in MCF-7 breast cancer cells. Molecular and cellular endocrinology, 2004, Apr-30, Volume: 219, Issue:1-2 Topics: Antineoplastic Agents; Breast Neoplasms; Cathepsin D; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Piperidines; RNA, Messenger; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2004
A new MCF-7 breast cancer cell line resistant to the arzoxifene metabolite desmethylarzoxifene. Molecular and cellular endocrinology, 2004, May-31, Volume: 220, Issue:1-2 Topics: Breast Neoplasms; Cathepsin D; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 1; Piperidines; Proto-Oncogene Proteins c-bcl-2; Receptors, Progesterone; Repressor Proteins; RNA, Messenger; Tamoxifen; Thiophenes; Transcription Factors	2004
Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells. BMC cancer, 2004, Aug-13, Volume: 4 Topics: Animals; Antineoplastic Agents, Hormonal; Arachidonic Acid; Breast Neoplasms; Colonic Neoplasms; Cyclooxygenase 2; Epoprostenol; Estrogen Antagonists; Humans; Isoenzymes; Liver; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured	2004
Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways. Molecular and cellular endocrinology, 2004, Nov-30, Volume: 227, Issue:1-2 Topics: Breast Neoplasms; Cycloheximide; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Immunoenzyme Techniques; Lactones; Leupeptins; Ligands; Macrolides; Molecular Chaperones; Proteasome Inhibitors; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Pyrrolidines; Signal Transduction; Tamoxifen; Thiophenes; Tumor Cells, Cultured	2004
Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer research, 2005, Aug-01, Volume: 65, Issue:15 Topics: Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Estrogen Receptor beta; Etoposide; Female; Humans; Mitoxantrone; Ovarian Neoplasms; Pyrrolidines; RNA Splicing; RNA Splicing Factors; RNA-Binding Proteins; RNA, Catalytic; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transfection	2005
Activity of estradiol and selective estrogen receptor modulators in the mouse N20.1 oligodendrocyte/astrocytes cell line. Neuro endocrinology letters, 2005, Volume: 26, Issue:5 Topics: Animals; Astrocytes; Blotting, Western; Cell Line; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression Regulation; Ligands; Luciferases; Mice; Neuroglia; Oligodendroglia; Plasmids; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transfection	2005
AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines. BMC cancer, 2006, May-02, Volume: 6 Topics: Acetyltransferases; Alleles; Breast Neoplasms; Cell Line, Tumor; Cloning, Molecular; Drug Resistance, Neoplasm; Estradiol; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Receptor Coactivator 3; Oncogene Proteins; Peptides; Polymerase Chain Reaction; Pyrrolidines; Raloxifene Hydrochloride; Reverse Transcriptase Polymerase Chain Reaction; Selective Estrogen Receptor Modulators; Sequence Analysis, DNA; Tamoxifen; Thiophenes; Trans-Activators	2006
Preventive therapy for breast cancer. Current oncology reports, 2012, Volume: 14, Issue:6 Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Humans; Meta-Analysis as Topic; Middle Aged; Piperidines; Preventive Medicine; Pyrrolidines; Raloxifene Hydrochloride; Receptor, ErbB-2; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes	2012
Polymer-drug conjugates for intracellar molecule-targeted photoinduced inactivation of protein and growth inhibition of cancer cells. Scientific reports, 2012, Volume: 2 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Proliferation; Drug Carriers; Estrogen Receptor alpha; Female; Humans; Light; MCF-7 Cells; Microscopy, Fluorescence; Photochemotherapy; Polymers; Reactive Oxygen Species; Tamoxifen; Thiophenes	2012
SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:5 Topics: Cell Transformation, Neoplastic; Cells, Cultured; Cytoprotection; Estradiol; Humans; Inactivation, Metabolic; Indoles; Mammary Glands, Human; MCF-7 Cells; Oxidants; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Reactive Oxygen Species; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Up-Regulation	2014
Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Molecular cancer therapeutics, 2014, Volume: 13, Issue:11 Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Progression; Estrogens; Female; Humans; MCF-7 Cells; Mice; Mice, Nude; Random Allocation; Receptors, Estrogen; Tamoxifen; Thiophenes; Transfection; Xenograft Model Antitumor Assays	2014
The shh signaling pathway is upregulated in multiple cell types in cortical ischemia and influences the outcome of stroke in an animal model. PloS one, 2015, Volume: 10, Issue:4 Topics: Animals; Behavior, Animal; Brain Ischemia; Cerebral Cortex; Cyclohexylamines; Hedgehog Proteins; Male; Mice; Signal Transduction; Stroke; Tamoxifen; Thiophenes	2015
A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1. Oncotarget, 2015, Dec-01, Volume: 6, Issue:38 Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents, Hormonal; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Proliferation; DNA-Binding Proteins; Drug Resistance, Neoplasm; Endoribonucleases; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Grading; Neoplasm Staging; Prognosis; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; Regulatory Factor X Transcription Factors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Survival Rate; Tamoxifen; Thiophenes; Transcription Factors; Tumor Cells, Cultured; Unfolded Protein Response; X-Box Binding Protein 1; Xenograft Model Antitumor Assays	2015
Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators. Journal of ovarian research, 2016, Feb-15, Volume: 9 Topics: Animals; Antineoplastic Agents, Hormonal; Carcinoma in Situ; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Estrogen Antagonists; Estrogens; Fallopian Tubes; Female; Gene Expression Regulation, Neoplastic; Genome; Humans; Mice; Neoplasms, Cystic, Mucinous, and Serous; Ovarian Neoplasms; Piperidines; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen; Thiophenes; Transcriptome	2016
Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers. International journal of molecular sciences, 2018, Feb-15, Volume: 19, Issue:2 Topics: Binding Sites; Breast Neoplasms; Cell Proliferation; Chromatin; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mutation; Protein Binding; Tamoxifen; Thiophenes	2018