Page last updated: 2024-08-18

thiophenes and sr9009

thiophenes has been researched along with sr9009 in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	24 (48.98)	24.3611
2020's	25 (51.02)	2.80

Authors

Authors	Studies
Banerjee, S; Burris, TP; Butler, AA; Cameron, MD; Hughes, T; Kamenecka, TM; Kojetin, DJ; Liu, J; Lundasen, T; Noel, R; Shin, Y; Solt, LA; Takahashi, JS; Wang, Y; Yoo, SH	1
Bass, J	1
Shea, SA	1
Amador, A; Banerjee, S; Burris, TP; El-Gendy, BM; Griffett, K; Huitron-Resendiz, S; Kamenecka, TM; Kazantzis, M; Roberts, AJ; Shin, Y; Solt, LA; Wang, Y	1
Laher, I; Li, S	1
Amador, A; Banerjee, S; Burris, TP; Kameneka, TM; Solt, LA; Wang, Y	1
Amador, A; Burris, TP; Huitron-Resendiz, S; Kamenecka, TM; Roberts, AJ; Solt, LA	1
Deventer, K; Geldof, L; Roels, K; Tudela, E; Van Eeno, P	1
Brandon-Warner, E; Donohue, TM; Li, T; Schrum, LW; Thomes, PG	1
Aonuma, K; Feng, D; Kimura, T; Murakoshi, N; Nogami, A; Ogura, Y; Qin, R; Sato, A; Stujanna, EN; Tajiri, K; Xu, D; Yamagami, F; Yonebayashi, S	1
Beauchamp, J; Billon, C; Boulinguiez, A; Burris, TP; Delhaye, S; Dombrowicz, D; Duez, HM; Duhem, C; Eeckhoute, J; Ferri, L; Haas, JT; Lancel, S; Mayeuf-Louchart, A; Pourcet, B; Sebti, Y; Sitaula, S; Staels, B; Thorel, Q; Vanhoutte, J; Zecchin, M	1
Kolar, MJ; Panda, S; Plikus, MV; Puca, F; Rommel, A; Saghatelian, A; Sulli, G; Verma, IM; Wang, X	1
Amador, A; Burris, TP; Kamenecka, TM; Solt, LA	1
Dong, Y; Guan, H; Li, F; Liu, H; Song, C; Tan, P; Wu, W; Zhang, Z; Zhao, L	1
Brooker, L; Chakrabarty, R; Chan, BKH; Davies, SR; Garrett, TR; Moawad, M	1
Botrè, F; de la Torre, X; Mazzarino, M; Rizzato, N; Stacchini, C	1
Dong, D; Li, Z; Wu, B; Yuan, X	1
Hisaoka-Nakashima, K; Kodama, K; Morioka, N; Nakamura, Y; Nakata, Y; Saeki, M; Tomori, M; Yoshikawa, K; Zhang, FF	1
Burris, TP; Farr, SA; Kermath, BA; Morley, JE; Musiek, ES; Niehoff, M; Roby, DA; Ruiz, F; Voorhees, JR; Zhang, J	1
Adlanmerini, M; Dierickx, P; Emmett, MJ; Jiang, C; Lazar, MA; Liu, M; Uehara, K	1
Atkins, AR; Bapat, SP; Burris, TP; Chang, C; Cho, H; Downes, M; Evans, RM; Kamenecka, TM; Leblanc, M; Liang, Y; Loo, CS; Solt, LA; Yu, RT; Zhao, X; Zheng, Y	1
Meng, J; Nakanishi, H; Ni, J; Qing, H; Saido, TC; Saito, T; Wu, Z	1
Alibhai, FJ; Bridle, BW; Burris, TP; Khatua, TN; Martino, TA; Rasouli, M; Reitz, CJ	1
Ishimaru, K; Nakajima, S; Nakamura, Y; Nakao, A; Yu, G	1
Adamson, A; Calverley, B; Chang, J; Garva, R; Holmes, DF; Jensen, O; Kadler, KE; Lu, Y; Mallikarjun, V; Meng, QJ; Pickard, A; Raymond-Hayling, H; Shearer, T; Swift, J; Yeung, CC	1
He, J; Liu, S; Shen, K; Wei, Y; Wu, K; Yang, H; Yang, X; Yue, J; Zhang, C	1
Gao, Y; Guo, F; Liu, C; Liu, H; Qi, D; Sun, X; Tao, T; Xiao, J; Zhao, L; Zhou, C; Zhu, Y	1
Hong, Q; Li, X; Shen, J; Shen, W; Wang, H; Wei, T; Wen, G; Ye, W; Zhang, J; Zhang, Q; Zhang, W	1
Benavides, GA; Darley-Usmar, VM; Frank, SJ; Kane, MS; Latimer, MN; Martino, TA; Mia, S; Reitz, CJ; Smith, SR; Sonkar, R; Young, ME; Zhang, J	1
Amir, M; Campbell, S; Kamenecka, TM; Solt, LA	1
Balfe, P; Borrmann, H; Borrow, P; Davies, R; Dickinson, M; James, W; Magri, A; McKeating, JA; Pedroza-Pacheco, I; Schilling, M; Vaughan-Jackson, A; Zhuang, X	1
Bedia-Diaz, G; Burris, TP; Elgendy, B; Griffett, K	1
Fu, Z; Hu, L; Ma, L; Ni, L; Ni, Y; Wang, Z; Zhao, Y	1
Shimozaki, K	1
Cutler, C; Viljanto, M; White, DL	1
Cao, X; Cheung, YM; Hong, H; Li, C; Tian, XY; Wu, Y	1
Cui, L; Ding, Y; Du, M; Li, X; Lin, H; Wang, S; Xu, F	1
Bogaert, W; Delker, DA; Han, S; Huang, Y; Huda, N; Jiang, Y; Kusumanchi, P; Liangpunsakul, S; Ma, J; Skill, NJ; Smalling, RV; Wang, L; Yang, Z; Zhang, T	1
Aizawa, S; Iijima, M; Sakai, T; Sakata, I; Takemi, S	1
Chen, M; Chen, X; Guo, L; Liu, K; Wang, F; Wang, Z; Wu, B; Xu, H; Yu, F; Zhang, T	1
Cai, P; Gao, LB; Jing, Q; Liu, ZH; Sun, Y; Wang, YH	1
Cai, Z; Ichii, O; Inaba, M; Kozai, M; Masum, MA; Mita, H; Takada, K; Wang, S	1
Hashizume, H; Hisaoka-Nakashima, K; Kochi, T; Kodama, K; Morioka, N; Nakamura, Y; Tsuruta, M; Zhang, FF	1
Cao, Z; Fu, L; Sun, H; Wang, M; Xia, H; Zhao, Z; Zhu, G	1
Conde-Sieira, M; de Pedro, N; Delgado, MJ; Herrera-Castillo, L; Isorna, E; Saiz, N; Soengas, JL	1
Kwak, YB; Yoo, HH; Yu, J	1
Huang, Q; Lei, S; Qiu, Z; Tian, L; Xia, ZY; Zhao, B; Zhao, X	1
Cheng, Y; Cui, M; Ding, Y; He, W; Li, L; Li, X; Li, Z; Tian, A; Yang, C; Zhao, Z; Zou, X	1
de Pedro, N; Delgado, MJ; Gómez-Boronat, M; Herrera-Castillo, L; Isorna, E; Saiz, N	1

Reviews

1 review(s) available for thiophenes and sr9009

Article	Year
Exercise Pills: At the Starting Line. Trends in pharmacological sciences, 2015, Volume: 36, Issue:12 Topics: Acetylcarnitine; Animals; Biomimetic Materials; Catechin; Exercise; Fibronectins; Humans; Molecular Targeted Therapy; Pyrrolidines; Resveratrol; Stilbenes; Thiazoles; Thiophenes	2015

Other Studies

48 other study(ies) available for thiophenes and sr9009

Article	Year
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature, 2012, Mar-29, Volume: 485, Issue:7396 Topics: Adipose Tissue; Animals; Biological Clocks; Circadian Rhythm; Disease Models, Animal; Energy Metabolism; HEK293 Cells; Humans; Hypothalamus; Liver; Metabolome; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muscle, Skeletal; Nuclear Receptor Subfamily 1, Group D, Member 1; Obesity; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes	2012
Drug discovery: Time in a bottle. Nature, 2012, May-02, Volume: 485, Issue:7396 Topics: Animals; Circadian Rhythm; Energy Metabolism; Humans; Lipid Metabolism; Male; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes	2012
Obesity and pharmacologic control of the body clock. The New England journal of medicine, 2012, Jul-12, Volume: 367, Issue:2 Topics: Adipose Tissue; Animals; Biological Clocks; Circadian Rhythm; Humans; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Obesity; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes	2012
Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nature communications, 2014, Dec-23, Volume: 5 Topics: Animals; Anxiety; ARNTL Transcription Factors; Behavior, Animal; Circadian Clocks; Circadian Rhythm; CLOCK Proteins; Cryptochromes; Feedback, Physiological; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Period Circadian Proteins; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Reward; Signal Transduction; Sleep, REM; Thiophenes	2014
Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression. PloS one, 2016, Volume: 11, Issue:3 Topics: Animals; Brain; Gene Deletion; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; Orexins; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes; Transcriptional Activation	2016
Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation. PloS one, 2016, Volume: 11, Issue:9 Topics: Animals; Circadian Rhythm; Electroencephalography; Light; Male; Mice, Inbred C57BL; Molecular Targeted Therapy; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Sleep; Sleep, REM; Thiophenes; Time Factors; Wakefulness	2016
In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011. International journal of molecular sciences, 2016, Oct-03, Volume: 17, Issue:10 Topics: Chromatography, High Pressure Liquid; Doping in Sports; Humans; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Retrospective Studies; Tandem Mass Spectrometry; Thiophenes	2016
Rev-erb agonist and TGF-β similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype. The international journal of biochemistry & cell biology, 2016, Volume: 81, Issue:Pt A Topics: 3T3 Cells; Androstadienes; Animals; Autophagosomes; Autophagy; Biomarkers; Cell Proliferation; Down-Regulation; Gene Knockdown Techniques; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Phenotype; Proto-Oncogene Proteins c-akt; Pyrrolidines; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Thiophenes; Transforming Growth Factor beta; Wortmannin	2016
Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism. PloS one, 2017, Volume: 12, Issue:12 Topics: Animals; Blotting, Western; Fluorescent Antibody Technique; Inflammation; Male; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Thiophenes; Ventricular Remodeling	2017
Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice. Gastroenterology, 2018, Volume: 154, Issue:5 Topics: Animals; Caspase 1; Cells, Cultured; Chemical and Drug Induced Liver Injury; Circadian Rhythm; Cytokines; Disease Models, Animal; Galactosamine; Genetic Predisposition to Disease; Inflammasomes; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophage Activation; Macrophages, Peritoneal; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; Peritonitis; Phenotype; Pyrrolidines; RNA Interference; Severity of Illness Index; Signal Transduction; Thiophenes; Time Factors; Transfection	2018
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature, 2018, 01-18, Volume: 553, Issue:7688 Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Circadian Clocks; Female; Glioblastoma; GTP Phosphohydrolases; Humans; Lipogenesis; Male; Membrane Proteins; Mice, Inbred C57BL; Neoplasms; Nevus; Nuclear Receptor Subfamily 1, Group D, Member 1; Oncogenes; Pyrrolidines; Signal Transduction; Thiophenes	2018
REV-ERBβ is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009. Biochemical pharmacology, 2018, Volume: 150 Topics: Animals; Circadian Rhythm; Electroencephalography; Electromyography; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes; Wakefulness	2018
REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018, Volume: 32, Issue:6 Topics: Animals; Biphenyl Compounds; Bone Resorption; Extracellular Signal-Regulated MAP Kinases; Fatty Acid-Binding Proteins; Female; Humans; MAP Kinase Signaling System; Mice; NFATC Transcription Factors; Nuclear Receptor Subfamily 1, Group D, Member 1; Osteoclasts; Ovariectomy; Proto-Oncogene Proteins c-fos; Pyrazoles; Pyrrolidines; RANK Ligand; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes; Transcription Factor RelA; Up-Regulation	2018
Production of certified reference materials for the sports doping control of the REV-ERB agonist SR9009. Drug testing and analysis, 2019, Volume: 11, Issue:2 Topics: Doping in Sports; Humans; Pyrrolidines; Reference Standards; Thiophenes	2019
A further insight into the metabolic profile of the nuclear receptor Rev-erb agonist, SR9009. Drug testing and analysis, 2018, Volume: 10, Issue:11-12 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Male; Metabolome; Microsomes, Liver; Nuclear Receptor Subfamily 1, Group D, Member 1; Polymorphism, Genetic; Pyrrolidines; Tandem Mass Spectrometry; Thiophenes	2018
Rev-erbα activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice. Pharmacological research, 2019, Volume: 141 Topics: Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Experimental; Down-Regulation; Hep G2 Cells; Humans; Hypoglycemic Agents; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Phosphoenolpyruvate Carboxykinase (GTP); Pyrrolidines; Thiophenes	2019
Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice. Brain, behavior, and immunity, 2019, Volume: 78 Topics: Animals; Astrocytes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glycine; Hyperalgesia; Inflammation; Interleukin-6; Male; Mice; Neuralgia; Nociceptors; Nuclear Receptor Subfamily 1, Group D, Member 1; Primary Cell Culture; Pyrrolidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Spinal Cord; Spinal Cord Dorsal Horn; Thiophenes; Tumor Necrosis Factor-alpha	2019
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease. PloS one, 2019, Volume: 14, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognitive Dysfunction; Disease Models, Animal; Disks Large Homolog 4 Protein; Hippocampus; Male; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Peptide Fragments; Pyrrolidines; Thiophenes	2019
SR9009 has REV-ERB-independent effects on cell proliferation and metabolism. Proceedings of the National Academy of Sciences of the United States of America, 2019, 06-18, Volume: 116, Issue:25 Topics: Animals; Cell Proliferation; Cell Respiration; Cell Survival; Dose-Response Relationship, Drug; Gene Expression; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes	2019
The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America, 2019, 09-10, Volume: 116, Issue:37 Topics: Amino Acid Motifs; Animals; Cell Differentiation; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Genetic Loci; HEK293 Cells; Humans; Interleukin-17; Mice; Mice, Transgenic; Multiple Sclerosis; Nuclear Receptor Subfamily 1, Group D, Member 1; Nuclear Receptor Subfamily 1, Group F, Member 3; Pyrrolidines; Response Elements; RNA-Seq; Th17 Cells; Thiophenes	2019
An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain. Journal of neuroinflammation, 2019, Aug-30, Volume: 16, Issue:1 Topics: Amyloid beta-Protein Precursor; Animals; Brain; CLOCK Proteins; Gene Knock-In Techniques; Inflammation; Inflammation Mediators; Locomotion; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrrolidines; Thiophenes	2019
SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome. Communications biology, 2019, Volume: 2 Topics: Animals; Biomarkers; Biopsy; Heart Failure; Immunohistochemistry; Inflammasomes; Mice; Myocardial Ischemia; Myocardial Reperfusion; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Thiophenes	2019
The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock. International journal of molecular sciences, 2019, Dec-14, Volume: 20, Issue:24 Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Allergic Agents; Bone Marrow; Circadian Clocks; Hypersensitivity; Immunoglobulin E; Interleukin-33; Male; Mast Cells; Mice; Mice, Inbred C57BL; NF-kappa B; Nuclear Receptor Subfamily 1, Group D, Member 1; Phosphatidylinositol 3-Kinases; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sleep; Thiophenes	2019
Circadian control of the secretory pathway maintains collagen homeostasis. Nature cell biology, 2020, Volume: 22, Issue:1 Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Carbazoles; Circadian Clocks; Collagen; Cyclic Nucleotide Phosphodiesterases, Type 4; Extracellular Matrix; Homeostasis; Mice, Transgenic; Pyrrolidines; SEC Translocation Channels; Secretory Pathway; Sulfonamides; Thiophenes; Vesicular Transport Proteins	2020
Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model. Journal of neuroinflammation, 2020, Jan-31, Volume: 17, Issue:1 Topics: Adolescent; Adult; Animals; Anti-Inflammatory Agents; Convulsants; Cytokines; Encephalitis; Epilepsy, Temporal Lobe; Gene Expression Regulation; Gliosis; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nuclear Receptor Subfamily 1, Group D, Member 1; Pilocarpine; Pyrrolidines; Status Epilepticus; Temporal Lobe; Thiophenes; Young Adult	2020
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis. Cell death & disease, 2020, 02-18, Volume: 11, Issue:2 Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Remodeling; Case-Control Studies; Cells, Cultured; Humans; Inflammation Mediators; Knee Joint; Male; Matrix Metalloproteinases; Mice, Inbred DBA; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Reactive Oxygen Species; Signal Transduction; Synovial Membrane; Synoviocytes; Synovitis; Thiophenes	2020
SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy. Theranostics, 2020, Volume: 10, Issue:10 Topics: Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Small Cell Lung Carcinoma; Thiophenes; Xenograft Model Antitumor Assays	2020
Differential effects of REV-ERBα/β agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption. American journal of physiology. Heart and circulatory physiology, 2020, 06-01, Volume: 318, Issue:6 Topics: Animals; ARNTL Transcription Factors; Circadian Clocks; Circadian Rhythm; Gene Expression; Gene Expression Regulation; Heart; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Thiophenes	2020
Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development. Biochemical and biophysical research communications, 2020, 07-05, Volume: 527, Issue:4 Topics: Animals; Bone Marrow Cells; Dendritic Cells; Female; Gene Deletion; Gene Expression Regulation, Developmental; Male; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes	2020
Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication. Scientific reports, 2020, 08-06, Volume: 10, Issue:1 Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; Circadian Clocks; HIV Long Terminal Repeat; HIV-1; Humans; Jurkat Cells; Macrophages; Promoter Regions, Genetic; Pyrrolidines; Receptors, Thyroid Hormone; rev Gene Products, Human Immunodeficiency Virus; Thiophenes; Virus Replication	2020
REV-ERB agonism improves liver pathology in a mouse model of NASH. PloS one, 2020, Volume: 15, Issue:10 Topics: Animals; Disease Models, Animal; Humans; Inflammation; Lipogenesis; Liver; Liver Cirrhosis; Mice; Non-alcoholic Fatty Liver Disease; Nuclear Receptor Subfamily 1, Group D, Member 1; Obesity; Pyrrolidines; Thiophenes	2020
Pharmacological activation of REV-ERBα improves nonalcoholic steatohepatitis by regulating intestinal permeability. Metabolism: clinical and experimental, 2021, Volume: 114 Topics: Animals; Autophagy; Blood Glucose; Caco-2 Cells; Cholesterol; Humans; Insulin; Intestinal Mucosa; Intestines; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Permeability; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Signal Transduction; Thiophenes; Tight Junctions; Triglycerides	2021
REV-ERB Agonist SR9009 Regulates the Proliferation and Neurite Outgrowth/Suppression of Cultured Rat Adult Hippocampal Neural Stem/Progenitor Cells in a Concentration-Dependent Manner. Cellular and molecular neurobiology, 2022, Volume: 42, Issue:6 Topics: Animals; Cell Proliferation; Cyclin A2; Hippocampus; Nerve Tissue Proteins; Neural Stem Cells; Neuronal Outgrowth; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Rats; Thiophenes	2022
In vitro metabolism of the REV-ERB agonist SR-9009 and subsequent detection of metabolites in associated routine equine plasma and urine doping control samples. Drug testing and analysis, 2022, Volume: 14, Issue:1 Topics: Animals; Chromatography, Liquid; Doping in Sports; Horses; Mass Spectrometry; Microsomes, Liver; Nuclear Receptor Subfamily 1, Group D, Member 1; Performance-Enhancing Substances; Pyrrolidines; Substance Abuse Detection; Thiophenes	2022
REV-ERBα agonist SR9009 suppresses IL-1β production in macrophages through BMAL1-dependent inhibition of inflammasome. Biochemical pharmacology, 2021, Volume: 192 Topics: Animals; ARNTL Transcription Factors; Cells, Cultured; Female; Inflammasomes; Interleukin-1beta; Macrophages; Mice; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Thiophenes	2021
Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss. BMC immunology, 2021, 08-16, Volume: 22, Issue:1 Topics: Abortion, Spontaneous; Animals; Cell Differentiation; Cytokines; Decidua; Disease Models, Animal; Female; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Pregnancy; Pyrrolidines; Signal Transduction; Th1 Cells; Thiophenes; U937 Cells	2021
The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease. JCI insight, 2021, 08-23, Volume: 6, Issue:16 Topics: Amidines; Animals; Cytochrome P-450 CYP4A; Disease Models, Animal; Ethanol; Fatty Acids; Hepatocytes; Humans; Lipid Metabolism; Lipidomics; Liver; Liver Diseases, Alcoholic; Male; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Primary Cell Culture; Pyrrolidines; Receptor, EphB2; Receptors, Cytoplasmic and Nuclear; RNA-Seq; Signal Transduction; Thiophenes; Up-Regulation	2021
The suppressive effect of REVERBs on ghrelin and GOAT transcription in gastric ghrelin-producing cells. Neuropeptides, 2021, Volume: 90 Topics: Acyltransferases; Animals; Cell Line; Circadian Rhythm; Gene Expression Regulation; Gene Knockdown Techniques; Ghrelin; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptor, ErbB-2; RNA, Messenger; RNA, Small Interfering; Stomach; Thiophenes	2021
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding. Nature communications, 2021, 09-07, Volume: 12, Issue:1 Topics: Animals; ARNTL Transcription Factors; Circadian Rhythm; Diacylglycerol O-Acyltransferase; Diet, High-Fat; Dietary Fats; Fatty Liver; Gene Expression Regulation; Homeostasis; Hyperlipidemias; Intestinal Mucosa; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; Obesity; Promoter Regions, Genetic; Protein Binding; Pyrrolidines; Signal Transduction; Thiophenes; Triglycerides	2021
Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence. Aging cell, 2021, Volume: 20, Issue:10 Topics: Animals; Cellular Senescence; DNA Damage; Humans; Mice; NF-E2-Related Factor 2; Pyrrolidines; Signal Transduction; Thiophenes	2021
REV-ERB agonist suppresses IL-17 production in γδT cells and improves psoriatic dermatitis in a mouse model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 144 Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; Down-Regulation; Female; Interleukin-17; Intraepithelial Lymphocytes; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; Psoriasis; Pyrrolidines; Signal Transduction; Skin; Thiophenes	2021
Stimulation of nuclear receptor REV-ERBs suppresses inflammatory responses in spinal microglia. Neurochemistry international, 2021, Volume: 151 Topics: Animals; Inflammation; Lipopolysaccharides; Microglia; Neuralgia; Pyrrolidines; Rats; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiophenes	2021
REV-ERBs negatively regulate mineralization of the cementoblasts. Biochemical and biophysical research communications, 2022, 01-08, Volume: 587 Topics: Alkaline Phosphatase; Animals; Biological Clocks; Calcification, Physiologic; Cell Differentiation; Cell Line, Transformed; Cell Proliferation; Cementogenesis; Dental Cementum; Female; Gene Expression Regulation; Humans; Integrin-Binding Sialoprotein; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Osteocalcin; Pyrrolidines; Signal Transduction; Sp7 Transcription Factor; Thiophenes	2022
REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish. International journal of molecular sciences, 2022, Mar-08, Volume: 23, Issue:6 Topics: Animals; Energy Metabolism; Goldfish; Mammals; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; RNA, Messenger; Thiophenes	2022
A quantitative method for the simultaneous detection of SR9009 and SR9011 in equine plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry. Drug testing and analysis, 2022, Volume: 14, Issue:8 Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Horses; Pyrrolidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Thiophenes	2022
Rev-erbs agonist SR9009 alleviates ischemia-reperfusion injury by heightening endogenous cardioprotection at onset of type-2 diabetes in rats: Down-regulating ferritinophagy/ferroptosis signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 154 Topics: Animals; Diabetes Mellitus, Type 2; Ferroptosis; Glycolipids; Myocardial Ischemia; Myocardial Reperfusion Injury; Pyrrolidines; Rats; Thiophenes	2022
Anti-influenza virus activity of the REV-ERBα agonist SR9009 and related analogues. Antiviral research, 2022, Volume: 207 Topics: Adamantane; Antiviral Agents; ARNTL Transcription Factors; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Interferons; Oseltamivir; Pyrrolidines; Ribavirin; Thiophenes	2022
Daily rhythms of REV-ERBα and its role as transcriptional repressor of clock genes in fish hepatic oscillator. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2023, Volume: 283 Topics: Animals; Circadian Rhythm; Liver; Mammals; Thiophenes; Transcription Factors	2023