thiophenes has been researched along with sr 8278 in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Burris, TP; Kamenecka, TM; Kojetin, D; Wang, Y | 1 |
| Burris, TP; Fernandez-Ruiz, R; Figueroa, AL; Gomis, R; Marroquí, L; Merino, B; Nadal, A; Quesada, I; Vieira, E | 1 |
| Chen, H; Hattori, MA; Isayama, K; Yamauchi, N | 1 |
| Chen, H; Hashimoto, S; Hattori, MA; Isayama, K; Kumazawa, M; Shigeyoshi, Y; Yamauchi, N; Zhao, L | 1 |
| Dong, D; Li, Z; Sun, H; Wu, B; Wu, Z; Xue, Y | 1 |
| Batista, TM; Borck, PC; Boschero, AC; Camargo, RL; Carneiro, EM; Vettorazzi, JF; Vieira, E | 1 |
| Billon, C; Burris, TP; Flaveny, CA; Valfort, AC; Welch, RD | 1 |
| Brown, D; Capen, D; Ferder, IC; Fung, L; Lassen, KG; Ohguchi, Y; Wang, N; Xavier, RJ; Zhang, X | 1 |
| Fang, X; Gao, J; Ge, Y; Huang, T; Li, Y; Xiao, H; Xu, Y; Yu, D; Zhang, Y; Zong, L | 1 |
| Griffin, P; Kim, DE; Kim, DH; Lee, J; Musiek, ES; Sheehan, PW; Yoon, SY | 1 |
| Chen, M; Chen, X; Guo, L; Wang, F; Wu, B; Xu, H; Xu, Y; Yu, F; Yu, J; Zhang, T; Zhou, C | 1 |
| Anabtawi, N; Cvammen, W; Kemp, MG | 1 |
| Chen, M; Dong, D; Lu, D; Wang, Y; Wang, Z; Wu, B; Wu, Z; Yu, P | 1 |
| Choe, HK; Choe, Y; Choi, JW; Choi, M; Jang, S; Kim, D; Kim, J; Kim, K; Moon, C; Park, I; Park, SH; Sun, W | 1 |
14 other study(ies) available for thiophenes and sr 8278
| Article | Year |
|---|---|
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.
Topics: Binding Sites; Cells, Cultured; Co-Repressor Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Gluconeogenesis; HEK293 Cells; Heme; Humans; Isoquinolines; Nuclear Receptor Subfamily 1, Group D, Member 1; Polymerase Chain Reaction; Protease Inhibitors; Thiophenes | 2011 |
Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Circadian Rhythm; Cytokines; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Glycine; Isoquinolines; Metformin; Mice; Nicotinamide Phosphoribosyltransferase; Nuclear Receptor Subfamily 1, Group D, Member 1; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Thiophenes | 2013 |
REV-ERBα inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids.
Topics: Animals; Cattle; Circadian Rhythm; Cyclooxygenase 2; Dinoprost; Endometrium; Epithelial Cells; Estradiol; Female; Gene Expression; Gonadal Steroid Hormones; Heme; Isoquinolines; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Progesterone; Rats; RNA, Messenger; Stromal Cells; Thiophenes; Transfection | 2014 |
Integration of the nuclear receptor REV-ERBα linked with circadian oscillators in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells.
Topics: 5-Aminolevulinate Synthetase; Animals; Animals, Genetically Modified; Circadian Rhythm; Female; Gene Expression Regulation; Glycine; Granulosa Cells; Heme; Interleukin-6; Isoquinolines; Ligands; Nuclear Receptor Subfamily 1, Group D, Member 1; Ovary; Period Circadian Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; RNA, Small Interfering; Thiophenes; Transcription Factors | 2015 |
A validated ultra-performance liquid chromatography-tandem mass spectrometry method to identify the pharmacokinetics of SR8278 in normal and streptozotocin-induced diabetic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Isoquinolines; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Thiophenes | 2016 |
Protein malnutrition after weaning disrupts peripheral clock and daily insulin secretion in mice.
Topics: Adipose Tissue, White; Animals; Biological Clocks; CLOCK Proteins; Diet, Protein-Restricted; Gene Expression Regulation, Developmental; Glycine; Hypothalamus; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoquinolines; Liver; Male; Mice, Inbred C57BL; Muscle, Skeletal; Neurons; Neuropeptide Y; Nuclear Receptor Subfamily 1, Group D, Member 1; Organ Specificity; Pro-Opiomelanocortin; Protein Deficiency; Random Allocation; Thiophenes; Weaning | 2017 |
Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle.
Topics: Animals; Cell Differentiation; Fibrosis; Isoquinolines; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Animal; Myoblasts; Nuclear Receptor Subfamily 1, Group D, Member 1; Receptors, Notch; Regeneration; Signal Transduction; Thiophenes; Wnt Proteins | 2017 |
Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Base Sequence; Fertility; Gene Expression Regulation, Developmental; Isoquinolines; Male; Meiosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; Promoter Regions, Genetic; Protein Binding; Spermatogenesis; Spermatozoa; Testis; Thiophenes | 2019 |
Rev-erbα can regulate the NF-κB/NALP3 pathway to modulate lipopolysaccharide-induced acute lung injury and inflammation.
Topics: Acute Lung Injury; Animals; Glycine; Interleukin-1beta; Isoquinolines; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; RAW 264.7 Cells; Signal Transduction; Thiophenes | 2019 |
Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; ARNTL Transcription Factors; Cell Line; Circadian Clocks; CLOCK Proteins; Disease Models, Animal; Isoquinolines; Macrophages; Mice; Mice, Knockout; Microglia; Nuclear Receptor Subfamily 1, Group D, Member 1; Plaque, Amyloid; Receptors, Cytoplasmic and Nuclear; Receptors, Purinergic P2Y12; Repressor Proteins; RNA, Small Interfering; Synapses; Thiophenes | 2020 |
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
Topics: Acute Disease; Animals; Basic-Leucine Zipper Transcription Factors; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; GABA Plasma Membrane Transport Proteins; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Isoquinolines; Kindling, Neurologic; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; RNA, Messenger; Seizures; Small Molecule Libraries; Thiophenes | 2021 |
Pharmacological inhibition of cryptochrome and REV-ERB promotes DNA repair and cell cycle arrest in cisplatin-treated human cells.
Topics: A549 Cells; Antineoplastic Agents; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Circadian Clocks; Cisplatin; Cryptochromes; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; G1 Phase Cell Cycle Checkpoints; HaCaT Cells; Humans; Isoquinolines; Nuclear Receptor Subfamily 1, Group D, Member 1; Protein-Tyrosine Kinases; Signal Transduction; Thiophenes; Xeroderma Pigmentosum Group A Protein | 2021 |
Involvement of REV-ERBα dysregulation and ferroptosis in aristolochic acid I-induced renal injury.
Topics: Animals; Aristolochic Acids; Cell Line; Cell Survival; Epithelial Cells; Ferroptosis; Gene Expression Regulation; Humans; Isoquinolines; Kidney Diseases; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Nuclear Receptor Subfamily 1, Group D, Member 1; Thiophenes | 2021 |
Pharmacological Rescue with SR8278, a Circadian Nuclear Receptor REV-ERBα Antagonist as a Therapy for Mood Disorders in Parkinson's Disease.
Topics: Animals; Humans; Isoquinolines; Mice; Mood Disorders; Neurodegenerative Diseases; Nuclear Receptor Subfamily 1, Group D, Member 1; Oxidopamine; Parkinson Disease; Quality of Life; Thiophenes; Tyrosine 3-Monooxygenase | 2022 |