thiophenes has been researched along with sc 514 in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (17.95) | 29.6817 |
| 2010's | 30 (76.92) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| Albee, L; Bonar, S; Graneto, M; Guzova, J; Hanau, C; Hauser, S; Huynh, K; Kishore, N; Mathialagan, S; Mielke, C; Perry, T; Sommers, C; Tripp, CS; Weier, R; Yao, M | 1 |
| Brady, JN; Jeong, SJ; Park, HU; Pise-Masison, CA; Radonovich, MF | 1 |
| Doi, T; Nakano, H; Saiki, I; Sakurai, H; Singhirunnusorn, P; Suzuki, S | 1 |
| Benson, N; Broomhead, DS; Grimley, RL; Ihekwaba, AE; Li, P; Waithe, D; Wilkinson, SJ | 1 |
| Brady, JN; Burke, A; Dasgupta, A; Jeong, SJ; Jung, KJ; Park, HU; Um, JH | 1 |
| Li, K; Manolson, MF; Tenenbaum, HC; Voronov, I | 1 |
| Liu, H; Lu, X; Schaefer, S; Wang, L | 1 |
| Boulukos, K; Clavel, S; Coldefy, AS; Dérijard, B; Pisani, DF; Siffroi-Fernandez, S | 1 |
| Duman, RS; Ferguson, D; Koo, JW; Nestler, EJ; Russo, SJ | 1 |
| Cheong, R; Levchenko, A; Tao, SC; Yin, Z; Zhu, H | 1 |
| Fritzsching, B; Frommhold, D; Koch, L; Poeschl, J | 1 |
| Chang, EJ; Kundu, JK; Liu, L; Shin, JW; Surh, YJ | 1 |
| Chen, Z; Doyle, T; Muscoli, C; Obeid, LM; Salvemini, D | 1 |
| Gedebjerg, A; Iversen, L; Johansen, C; Kragballe, K; Riis, JL | 1 |
| Friedman, S; Glogauer, M; Huang, GT; Torneck, CD; Yamagishi, VT | 1 |
| Buch, S; Kumar, A; Shah, A; Singh, DP | 1 |
| Iversen, L; Johansen, C; Kragballe, K; Otkjaer, K; Riis, JL; Vestergaard, C | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Nakae, H; Ozaki, K | 1 |
| Islam, KN; Koch, WJ | 1 |
| Kumar, A; Liu, X; Qureshi, N; Shah, A; Silverstein, PS; Singh, V | 1 |
| Huang, WC; Johnson, JL; Newby, AC; Sala-Newby, GB; Susana, A | 1 |
| Davis, CT; Gibson, CC; Grossmann, AH; Guo, J; Li, DY; London, NR; Shi, DS; Smith, MC; Sorensen, LK; Thomas, KR; Tong, Z; Zhu, W | 1 |
| Han, Q; Ip, MS; Mak, JC; Yeung, SC | 1 |
| Chen, M; da Silva, AA; do Carmo, JM; Hall, JE; Ostrowski, M; Rajagopalan, S; Ryan, MJ; Xiang, L; Ying, Z | 1 |
| Jeong, J; Lee, KH; Yoo, CG | 1 |
| Chim, SM; Feng, H; Gu, Q; Liu, Q; Pavlos, N; Tan, RX; Tickner, J; Wang, Q; Wei, Q; Wu, H; Xu, J; Zhao, J; Zheng, MH; Zhou, L | 1 |
| Álvarez-Cienfuegos, A; Álvarez-Vallina, L; Compte, M; Guijarro-Muñoz, I; Sanz, L | 1 |
| Negi, G; Sharma, SS | 1 |
| Li, YH; Tan, W; Tan, ZH; Tian, Y; Zhang, Y | 1 |
| Cao, HH; Chen, YJ; Cheng, BC; Fong, WF; Fu, XQ; Guo, H; Kwan, HY; Lee, SK; Li, T; Su, T; Tse, AK; Yu, ZL; Zhu, PL | 1 |
| Cao, M; Chen, C; Li, N; Peng, J; Qi, P; Song, L; Wu, D; Zhang, M; Zhao, J | 1 |
| Huang, X; Jiang, Y; Luo, W; Pinhu, L; Qin, Y; Sooranna, SR; Xiang, S; Zeng, Y | 1 |
| Byeon, S; Choi, SK; Kwon, Y; Lee, YH | 1 |
| Amaro, A; Bachetti, T; Bianchi, G; Emionite, L; Pfeffer, U; Piaggio, F; Raffaghello, L; Ravera, S; Traverso, C | 1 |
| Basu, S; Jalodia, K; Peterson, RT; Ranjan, S; Sachidanandan, C; Yeh, JJ | 1 |
| Cao, H; Jiang, S; Liu, Y; Shao, C; Shao, S; Yuan, R; Zhang, W | 1 |
| Gurney, LRI; Jones, AT; Robson, SC; Taggart, J; Taggart, MJ; Tong, WC | 1 |
| Chen, YM; Gao, HL; Kang, YM; Li, HB; Li, Y; Liu, KL; Qi, J; Shi, XL; Sun, TZ; Yu, XJ; Zhu, GQ | 1 |
| Fujimori, K; Maehara, T | 1 |
39 other study(ies) available for thiophenes and sc 514
| Article | Year |
|---|---|
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Blotting, Western; Cell Adhesion; Cell Line; Cell Nucleus; Cells, Cultured; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; Glutathione Transferase; Humans; Hydrolysis; I-kappa B Kinase; Inflammation; Inhibitory Concentration 50; Interleukin-1; Kinetics; Lipopolysaccharides; Models, Chemical; NF-kappa B; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Protein Transport; Rats; Rats, Wistar; Recombinant Proteins; Signal Transduction; Synovial Membrane; Thiophenes; Time Factors; Transcription Factor RelA; Transcription, Genetic; Transcriptional Activation | 2003 |
A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Fibroblasts; Gene Products, tax; I-kappa B Kinase; Immunoprecipitation; Luciferases; Mice; Mutation; NF-kappa B; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Serine; T-Lymphocytes; Thiophenes; Transcription Factor RelA; Transcription, Genetic; Transcriptional Activation; Transfection; Transgenes; Tumor Suppressor Protein p53 | 2005 |
Identification of TNF-alpha-responsive NF-kappaB p65-binding element in the distal promoter of the mouse serine protease inhibitor SerpinE2.
Topics: Animals; Base Sequence; Binding Sites; Cell Nucleus; Fibroblasts; Gene Expression; I-kappa B Kinase; Mice; Promoter Regions, Genetic; Protein Transport; Response Elements; RNA, Messenger; Serpin E2; Serpins; Thiophenes; Transcription Factor RelA; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2006 |
Bridging the gap between in silico and cell-based analysis of the nuclear factor-kappaB signaling pathway by in vitro studies of IKK2.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Cell Line, Tumor; Cell Nucleus; Computer Simulation; Cytoplasm; Glutathione Transferase; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1alpha; Kinetics; Models, Biological; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Kinase Inhibitors; Recombinant Fusion Proteins; Signal Transduction; Thiophenes | 2007 |
PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells.
Topics: Apoptosis; bcl-Associated Death Protein; Caspase 9; Cell Cycle; Cell Line, Transformed; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Cytochromes c; Human T-lymphotropic virus 1; Humans; Models, Biological; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Thiophenes; Tumor Suppressor Protein p53 | 2008 |
Benzo[a]pyrene inhibits osteoclastogenesis by affecting RANKL-induced activation of NF-kappaB.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carcinogens, Environmental; Cell Differentiation; Cell Line; Cytochrome P-450 CYP1B1; Gene Expression; Gliotoxin; Mice; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Proto-Oncogene Proteins c-myc; RANK Ligand; Receptors, Aryl Hydrocarbon; RNA, Messenger; Thiophenes | 2008 |
Activation of NF-kappaB is a critical element in the antiapoptotic effect of anesthetic preconditioning.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Caspase 3; Cytochromes c; I-kappa B Kinase; I-kappa B Proteins; In Vitro Techniques; Male; Methyl Ethers; Myocardial Reperfusion Injury; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Perfusion; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Sevoflurane; Thiophenes; Ventricular Function, Left; Ventricular Pressure | 2009 |
Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells.
Topics: Animals; Anthracenes; Cell Line; Cell Nucleus; Chromones; Exportin 1 Protein; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Isoquinolines; Karyopherins; MAP Kinase Kinase 3; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Cells; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptors, Cytoplasmic and Nuclear; Signal Transduction; SKP Cullin F-Box Protein Ligases; Sulfonamides; Thiophenes; Transfection | 2010 |
Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior.
Topics: Animals; Cell Proliferation; Cells, Cultured; Depressive Disorder; Female; Hippocampus; Interleukin-1beta; Male; Mice; Mice, Transgenic; Neurogenesis; Neurons; NF-kappa B; Phenylenediamines; Rats; Rats, Sprague-Dawley; Restraint, Physical; Signal Transduction; Stem Cells; Stress, Psychological; Thiophenes | 2010 |
An integrated micro-electro-fluidic and protein arraying system for parallel analysis of cell responses to controlled microenvironments.
Topics: Biomedical Engineering; Cell Culture Techniques; Cells, Cultured; Culture Media; Endothelial Cells; Equipment Design; Extracellular Matrix Proteins; Humans; I-kappa B Kinase; Insulin-Like Growth Factor I; Microfluidic Analytical Techniques; NF-kappa B; Protein Array Analysis; Signal Transduction; Thiophenes; Tumor Necrosis Factor-alpha | 2010 |
Lipopolysaccharide-induced expression of Th1/Th2 cytokines in whole neonatal cord and adult blood: role of nuclear factor-kappa B and p38 MAPK.
Topics: Adult; Cytokines; Enzyme Inhibitors; Fetal Blood; Flow Cytometry; Humans; Imidazoles; Infant, Newborn; Lipopolysaccharides; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Th1 Cells; Th2 Cells; Thiophenes | 2011 |
Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β.
Topics: Active Transport, Cell Nucleus; Animals; Blotting, Western; Cell Nucleus; Electrophoretic Mobility Shift Assay; Extracellular Signal-Regulated MAP Kinases; I-kappa B Kinase; I-kappa B Proteins; Male; Mice; Mice, Hairless; NF-kappa B; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Oligonucleotides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Skin; Thiophenes; Transcription Factor RelA; Ultraviolet Rays | 2011 |
Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.
Topics: Animals; Antibodies, Monoclonal; Ceramides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Extremities; Hot Temperature; Hyperalgesia; Imidazoles; Injections; Male; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes; Touch | 2011 |
Tumor necrosis factor α-mediated induction of interleukin 17C in human keratinocytes is controlled by nuclear factor κB.
Topics: Adult; Base Sequence; Binding Sites; Cells, Cultured; DNA; Humans; Interleukin-17; Keratinocytes; NF-kappa B p50 Subunit; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Signal Transduction; Thiophenes; Transcription Factor RelA; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2011 |
Blockade of TLR2 inhibits Porphyromonas gingivalis suppression of mineralized matrix formation by human dental pulp stem cells.
Topics: Antibodies, Neutralizing; Cell Culture Techniques; Cell Differentiation; Dental Pulp; Dentinogenesis; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Humans; I-kappa B Kinase; Lipopolysaccharides; Osteocalcin; Phosphoproteins; Porphyromonas gingivalis; Real-Time Polymerase Chain Reaction; Sialoglycoproteins; Stem Cells; Thiophenes; Toll-Like Receptor 2 | 2011 |
HIV-1 envelope protein gp120 up regulates CCL5 production in astrocytes which can be circumvented by inhibitors of NF-κB pathway.
Topics: Astrocytes; Cells, Cultured; Chemokine CCL5; HIV Envelope Protein gp120; Humans; NF-kappa B; RNA, Small Interfering; Thiophenes; Transfection; Up-Regulation | 2011 |
CCL27 expression is regulated by both p38 MAPK and IKKβ signalling pathways.
Topics: Adenosine Triphosphatases; Base Sequence; Binding Sites; Cation Transport Proteins; Chemokine CCL27; Copper-Transporting ATPases; Epidermal Cells; Gene Expression Regulation; Humans; I-kappa B Kinase; Imidazoles; Interleukin-1beta; Keratinocytes; MAP Kinase Signaling System; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors; Protein Multimerization; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Thiophenes; Transcription Factor RelA | 2011 |
Interleukin (IL)-17A synergistically enhances CC chemokine ligand 20 production in IL-1β-stimulated human gingival fibroblasts.
Topics: Blotting, Western; Cells, Cultured; Chemokine CCL20; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gingiva; Humans; I-kappa B Kinase; Imidazoles; Interleukin-17; Interleukin-1beta; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Interleukin-17; Signal Transduction; Thiophenes | 2012 |
Involvement of nuclear factor κB (NF-κB) signaling pathway in regulation of cardiac G protein-coupled receptor kinase 5 (GRK5) expression.
Topics: Acetylcysteine; Animals; G-Protein-Coupled Receptor Kinase 5; Gene Expression Regulation, Enzymologic; Heart Diseases; Myocytes, Cardiac; NF-kappa B p50 Subunit; Primary Cell Culture; Promoter Regions, Genetic; Rats; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor RelA | 2012 |
Methamphetamine increases LPS-mediated expression of IL-8, TNF-α and IL-1β in human macrophages through common signaling pathways.
Topics: Cell Line; Cell Nucleus; Humans; Inflammation Mediators; Interleukin-1beta; Interleukin-8; Lipopolysaccharides; Macrophages; Methamphetamine; Mitogen-Activated Protein Kinases; NF-kappa B p50 Subunit; Phosphatidylinositol 3-Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiophenes; Tumor Necrosis Factor-alpha | 2012 |
Classical macrophage activation up-regulates several matrix metalloproteinases through mitogen activated protein kinases and nuclear factor-κB.
Topics: Atherosclerosis; Cell Adhesion; Chromones; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Interferon-gamma; Interleukin-1; Janus Kinase 2; Lipopolysaccharides; Macrophage Activation; Macrophages; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; NF-kappa B; Phenotype; Phosphatidylinositol 3-Kinases; Receptors, IgG; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor; Thiophenes; Tissue Inhibitor of Metalloproteinases; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.
Topics: Adjuvants, Immunologic; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Arthritis; Cadherins; Capillary Permeability; Cell Line; Endothelial Cells; Enzyme Activation; GTPase-Activating Proteins; Humans; Interleukin-1beta; Myeloid Differentiation Factor 88; NF-kappa B; Protein Kinase Inhibitors; Protein Transport; Purines; Receptors, Interleukin; Signal Transduction; Thiophenes | 2012 |
Intermittent hypoxia-induced NF-κB and HO-1 regulation in human endothelial EA.hy926 cells.
Topics: Apoptosis; Basic-Leucine Zipper Transcription Factors; Cell Hypoxia; Cell Line; Culture Media; Cytokines; Endothelial Cells; Fanconi Anemia Complementation Group Proteins; Gene Knockdown Techniques; Heme Oxygenase-1; Hemin; Humans; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Signal Transduction; Thiophenes | 2013 |
Inhibitor κB kinase 2 is a myosin light chain kinase in vascular smooth muscle.
Topics: Animals; Blood Pressure; Cell Line; Crosses, Genetic; Dermatitis; Humans; I-kappa B Kinase; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosins; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor, Type I; Recombinant Fusion Proteins; Thiophenes; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2013 |
Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Line, Tumor; Dipeptides; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-8; Ketones; Leupeptins; Lysosomes; Microtubule-Associated Proteins; Mutation, Missense; NF-kappa B; NF-KappaB Inhibitor alpha; Proteasome Inhibitors; Proteolysis; Pyrazines; Thiophenes; Time Factors | 2013 |
SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Division; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; I-kappa B Kinase; Mice; NF-kappa B; Osteoclasts; RANK Ligand; Signal Transduction; Thiophenes | 2013 |
Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes.
Topics: Active Transport, Cell Nucleus; Cell Adhesion; Cell Adhesion Molecules; Cell Nucleus; Cells, Cultured; Coculture Techniques; Cytokines; Humans; Inflammation Mediators; Leukocytes; Lipopolysaccharides; NF-kappa B; Pericytes; Signal Transduction; Thiophenes; Toll-Like Receptor 4; Up-Regulation | 2014 |
Inhibition of IκB kinase (IKK) protects against peripheral nerve dysfunction of experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; I-kappa B Kinase; Male; Neural Conduction; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Thiophenes | 2015 |
IκB kinase b Mediating the Downregulation of p53 and p21 by Lipopolysaccharide in Human Papillomavirus 16
Topics: Cell Line, Tumor; Down-Regulation; Female; Human papillomavirus 16; Humans; I-kappa B Kinase; Lipopolysaccharides; Proto-Oncogene Proteins p21(ras); Thiophenes; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms | 2016 |
Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition.
Topics: Alkylating Agents; Animals; Cell Death; Cell Line, Tumor; DNA Damage; Humans; I-kappa B Kinase; Melanoma; Mice; Neoplasm Metastasis; Nitrosourea Compounds; Oxidative Stress; Thiophenes; Xenograft Model Antitumor Assays | 2017 |
KH-type splicing regulatory protein mediate inflammatory response in gastric epithelial cells induced by lipopolysaccharide.
Topics: Cyclooxygenase 2; Epithelial Cells; Inflammation; Lipopolysaccharides; Macrophages; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Processing, Post-Translational; RNA-Binding Proteins; Signal Transduction; Thiophenes; Trans-Activators; Transcription Factors | 2017 |
Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-
Topics: A549 Cells; Acute-Phase Proteins; Animals; Carrier Proteins; Chemokine CX3CL1; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Lipopolysaccharides; Lung; Male; Membrane Glycoproteins; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peptides; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes | 2017 |
Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone.
Topics: Animals; I-kappa B Kinase; Male; Mesenteric Arteries; Muscle Proteins; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Rats, Sprague-Dawley; Thiophenes; Vasoconstriction | 2018 |
Curcumin induces a fatal energetic impairment in tumor cells in vitro and in vivo by inhibiting ATP-synthase activity.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Curcumin; Energy Metabolism; Female; Hexokinase; I-kappa B Kinase; L-Lactate Dehydrogenase; Malondialdehyde; Mice; Mice, Nude; Mitochondrial Proton-Translocating ATPases; Neoplasms; Neovascularization, Pathologic; Oxygen Consumption; Phosphofructokinases; Pyruvate Kinase; Reactive Oxygen Species; Thiophenes | 2018 |
Small Molecule Inhibitors of NFkB Reverse Iron Overload and Hepcidin Deregulation in a Zebrafish Model for Hereditary Hemochromatosis Type 3.
Topics: Animals; Disease Models, Animal; Gene Knockdown Techniques; Hemochromatosis; Hepcidins; Iron; NF-kappa B; Receptors, Transferrin; Signal Transduction; Thiophenes; Up-Regulation; Zebrafish; Zebrafish Proteins | 2018 |
Inhibition of IκB Kinase 2 Attenuated the Proliferation and Induced Apoptosis of Gastric Cancer.
Topics: Aged; Animals; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Female; Humans; I-kappa B Kinase; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Random Allocation; Stomach Neoplasms; Thiophenes | 2019 |
Inhibition of Inflammatory Changes in Human Myometrial Cells by Cell Penetrating Peptide and Small Molecule Inhibitors of NFκB.
Topics: Cell Membrane; Cell Membrane Permeability; Cell-Penetrating Peptides; Cells, Cultured; Drug Carriers; Female; Humans; I-kappa B Kinase; Myometrium; NF-kappa B; Pregnancy; Premature Birth; Primary Cell Culture; Signal Transduction; Thiophenes; Up-Regulation | 2018 |
Inhibition of Hypothalamic Inhibitor κB Kinase β/Nuclear Transcription Factor κB Pathway Attenuates Metabolism and Cardiac Dysfunction in Type 2 Diabetic Rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Blood Glucose; Cytokines; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Echocardiography; I-kappa B Kinase; Inflammation; Male; NF-kappa B; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes | 2020 |
Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-κB p65.
Topics: Animals; Cell Nucleus; Dinoprost; I-kappa B Kinase; Interferon-gamma; Interleukin-10; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Prostaglandins F, Synthetic; RAW 264.7 Cells; Receptors, Prostaglandin; Signal Transduction; Thiophenes; Transcription Factor RelA | 2020 |