thiophenes has been researched along with rs 5186 in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (30.00) | 18.7374 |
| 1990's | 12 (60.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tomoda, H | 1 |
| Nakagawa, A; Shigeta, A; Takasaki, W; Tanaka, Y | 1 |
| Asai, F; Ito, T; Matsuda, K; Oshima, T; Ushiyama, S | 2 |
| Hashimoto, H; Hieda, N; Ito, T; Ogawa, K; Okumura, K; Satake, T; Toki, Y | 2 |
| Asai, F; Ikeda, T; Ito, T; Matsuda, K; Nakagawa, A; Oshima, T; Terada, A; Ushiyama, S; Yamazaki, M | 1 |
| Hsueh, W; Needleman, P; Spaethe, SM | 1 |
| Asai, F; Ito, T; Matsuda, K; Oshima, T; Terada, A; Ushiyama, S; Yamazaki, M | 1 |
| Hieda, N; Ito, T; Ogawa, K; Ogawa, T; Ozawa, T; Satake, T; Sugiyama, S; Toki, Y | 1 |
| Inaba, H; Kosuge, K; Mizuno, A; Nagashima, S; Nakashima, M; Uematsu, T | 1 |
| Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Yamaguchi, T | 1 |
| Kosuge, K; Matsuno, H; Nakashima, M; Takasaki, W; Tanaka, Y; Uematsu, T; Wada, K; Yamamura, N | 1 |
| Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Terada, A; Yamaguchi, T | 1 |
| Hisamoto, M; Ikeda, T; Itoh, K; Matsuda, K; Mukaiyama, O; Satoh, Y; Yamaguchi, T; Yamamura, N | 1 |
| Asai, F; Matsuda, K; Nakagawa, A; Oshima, T; Sugidachi, A; Takasaki, W; Tanaka, Y; Ushiyama, S | 1 |
| Itoh, K; Mukaiyama, O; Satoh, Y; Takahashi, E; Yamaguchi, T | 1 |
| Okamoto, H; Takeuchi, H; Tanabe, M; Yamazaki, M | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Liu, Q; Matsuda, T; Myou, S; Nobata, K; Yamamori, C | 1 |
| Fujimura, M; Hirose, T; Myou, S; Tachibana, H; Yoshimi, Y | 1 |
20 other study(ies) available for thiophenes and rs 5186
| Article | Year |
|---|---|
Experimental evaluation of coronary thrombodynamics and effects of pharmacological interventions in acute coronary syndromes.
Topics: Animals; Antithrombins; Arginine; Coronary Circulation; Coronary Thrombosis; Dogs; Heparin; Myocardial Infarction; Pipecolic Acids; Sulfonamides; Thiophenes; Thrombolytic Therapy; Thromboxane-A Synthase; Urokinase-Type Plasminogen Activator | 1992 |
Enzyme-linked immunosorbent assay of CS-518, a thromboxane synthetase inhibitor, in rabbit plasma and platelets.
Topics: Administration, Oral; Animals; Blood Platelets; Enzyme-Linked Immunosorbent Assay; Evaluation Studies as Topic; Male; Plasma; Rabbits; Reproducibility of Results; Thiophenes; Thromboxane-A Synthase | 1992 |
Reduction of infarct size and infiltration of polymorphonuclear leukocytes by a thromboxane synthetase inhibitor. Studies in a rabbit ischemic heart model.
Topics: Animals; Coronary Vessels; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Peroxidase; Rabbits; Staining and Labeling; Thiophenes; Thromboxane-A Synthase | 1990 |
In vitro antiplatelet profiles of the new thromboxane synthetase inhibitor sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Aspirin; Dogs; Humans; Imidazoles; In Vitro Techniques; Male; Methacrylates; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thiophenes; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1991 |
Protective effects of a thromboxane synthetase inhibitor, a thromboxane antagonist, a lipoxygenase inhibitor and a leukotriene C4, D4 antagonist on myocardial injury caused by acute myocardial infarction in the canine heart.
Topics: Animals; Arrhythmias, Cardiac; Benzoquinones; Cardiomyopathies; Chromones; Coronary Disease; Dogs; Hemorrhage; Lipoxygenase Inhibitors; Male; Myocardial Infarction; Myocardium; Neutrophils; Quinones; SRS-A; Thiophenes; Thromboxane A2; Thromboxane-A Synthase | 1989 |
RS-5186, a novel, long-acting thromboxane synthetase inhibitor.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Death, Sudden; Dogs; Humans; In Vitro Techniques; Kinetics; Microsomes; Rabbits; Reference Values; Thiophenes; Thromboxane-A Synthase | 1989 |
Pharmacological manipulation of inflammation in rabbit hydronephrosis: effects of a combined cyclooxygenase/lipoxygenase inhibitor ethoxyquin, a thromboxane synthase inhibitor RS-5186 and a PAF antagonist L-659,989.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Ethoxyquin; Fatty Acids, Nonesterified; Furans; Hydronephrosis; Inflammation; Kidney; Leukotriene B4; Lipoxygenase Inhibitors; Male; Perfusion; Platelet Activating Factor; Quinolines; Rabbits; Thiophenes; Thromboxane-A Synthase | 1989 |
RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action.
Topics: Animals; Arachidonic Acids; Blood Platelets; Dogs; Female; Humans; In Vitro Techniques; Male; Microsomes; Platelet Count; Prostaglandins; Rabbits; Rats; Rats, Inbred Strains; Thiophenes; Thrombosis; Thromboxane B2; Thromboxane-A Synthase | 1988 |
Myocardial salvage by a novel thromboxane A2 synthetase inhibitor in a canine coronary occlusion-reperfusion model.
Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Coronary Vessels; Dogs; Hemodynamics; In Vitro Techniques; Male; Neutrophils; Risk Factors; Thiophenes; Thromboxane A2; Thromboxane-A Synthase | 1988 |
Effect of a novel thromboxane A2 synthetase inhibitor on ischemia-induced mitochondrial dysfunction in canine hearts.
Topics: Animals; Blood Pressure; Coronary Disease; Dogs; Female; Heart Rate; In Vitro Techniques; Lysosomes; Male; Mitochondria, Heart; Oxygen Consumption; Thiophenes; Thromboxane A2; Thromboxane-A Synthase; Time Factors | 1988 |
Pharmacokinetic and pharmacodynamic profiles of CS-518, a selective, long-lasting thromboxane synthase inhibitor, after single and multiple oral administration to healthy volunteers.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Administration, Oral; Adult; Drug Administration Schedule; Eating; Half-Life; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiophenes; Thromboxane B2; Thromboxane-A Synthase | 1994 |
Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Eosinophils; Epoprostenol; Guinea Pigs; In Vitro Techniques; Male; Peroxidases; Platelet Activating Factor; Pulmonary Alveoli; Superoxides; Thiophenes; Thromboxane A2; Thromboxane-A Synthase | 1993 |
Changes in plasma and urinary 11-dehydrothromboxane B2 in healthy subjects produced by oral CS-518, a novel thromboxane synthase inhibitor.
Topics: Administration, Oral; Adult; Half-Life; Humans; Male; Thiophenes; Thromboxane B2; Thromboxane-A Synthase | 1993 |
Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Chlorpheniramine; Disease Models, Animal; Guinea Pigs; Indomethacin; Male; Methacrylates; Ovalbumin; Propranolol; Prostaglandin Endoperoxides, Synthetic; SRS-A; Thiophenes; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents | 1993 |
Alteration of eicosanoid production in the sensitized guinea pig lung by CS-518.
Topics: Administration, Oral; Animals; Arachidonic Acid; Eicosanoids; Guinea Pigs; Histamine; Indomethacin; Lung; Male; Ovalbumin; Prostaglandins; Radioimmunoassay; SRS-A; Thiophenes; Thromboxane A2; Thromboxane-A Synthase; Vaccination | 1993 |
Superiority of plasma 11-dehydro-TXB2 to TXB2 as an index of in vivo TX formation in rabbits after dosing of CS-518, a TX synthase inhibitor.
Topics: Animals; Arachidonic Acid; Eicosanoids; Immunoenzyme Techniques; Infusions, Intravenous; Male; Rabbits; Radioimmunoassay; Thiophenes; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1993 |
Effects of a thromboxane synthase inhibitor (CS-518) on the eosinophil-dependent late asthmatic response and airway hyperresponsiveness in guinea pigs.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Pulmonary Eosinophilia; Thiophenes; Thromboxane-A Synthase | 1996 |
Effects of thromboxane synthetase inhibitor (RS-5186) on experimentally-induced cerebral vasospasm.
Topics: Animals; Basilar Artery; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoprostenol; Neuroprotective Agents; Subarachnoid Hemorrhage; Thiophenes; Thromboxane A2; Thromboxane-A Synthase; Vasospasm, Intracranial | 1999 |
Effect of thromboxane synthase inhibitor, CS-518, on propranolol-induced bronchoconstriction in guinea pigs.
Topics: Adrenergic beta-Antagonists; Animals; Bronchoconstriction; Enzyme Inhibitors; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Muscarinic Agonists; Propranolol; Respiration, Artificial; Thiophenes; Thromboxane A2; Thromboxane-A Synthase | 2000 |
Effect of thromboxane A2 (TXA2) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs.
Topics: Animals; Antigens; Bridged Bicyclo Compounds; Bronchoconstriction; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Guinea Pigs; Male; Methacrylates; Receptors, Thromboxane; Thiophenes; Thromboxane-A Synthase | 2001 |