Compounds > thiophenes
Page last updated: 2024-08-18

thiophenes and r-138727

thiophenes has been researched along with r-138727 in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (63.16)29.6817
2010's7 (36.84)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asai, F; Hasegawa, M; Isobe, T; Jakubowski, JA; Ogawa, T; Sugidachi, A1
Farid, NA; Kurihara, A; Ruterbories, KJ; Tian, Y; Verburg, EM; Weerakkody, GJ; Wickremsinhe, ER1
Blair, PE; Farid, NA; Gillespie, TA; Goldberg, MJ; Kurihara, A; Rash, TJ; Smith, RL1
Barnard, MR; Fox, ML; Frelinger, AL; Furman, MI; Jakubowski, JA; Li, Y; Linden, MD; Michelson, AD; Sugidachi, A; Winters, KJ1
Barnard, MR; Fox, ML; Frelinger, AL; Furman, MI; Jakubowski, JA; Li, Y; Linden, MD; Michelson, AD; Sugidachi, A; Tarnow, I; Winters, KJ1
Buckland, RJ; Jakubowski, JA; Judge, HM; Storey, RF; Sugidachi, A1
Algaier, I; Asai, F; Jakubowski, JA; von Kügelgen, I1
Farid, NA; Hagihara, K; Ikeda, T; Kazui, M; Kurihara, A; Nishiya, Y1
Farid, NA; Fusegawa, K; Hagihara, K; Ikeda, T; Ikenaga, H; Kazui, M; Kurihara, A; Nanba, T; Okazaki, O; Takahashi, M1
Antman, EM; Braunwald, E; Ernest, CS; Li, YG; Macias, WL; Ni, L; Riesmeyer, JR; Rohatagi, S; Salazar, DE; Small, DS; Weerakkody, GJ; Wiviott, SD; Wrishko, RE1
Ernest, CS; Heathman, MA; Wrishko, RE1
Ernest, CS; Farid, NA; Li, YG; Ni, L; Payne, CD; Salazar, DE; Small, DS; Winters, KJ; Wrishko, RE1
Farid, NA; Jakubowski, JA; Kothare, P; Lachno, DR; Li, YG; Ni, L; Payne, CD; Salazar, DE; Small, DS; Thieu, VT; Winters, KJ; Yuen, E1
Farid, NA; Hagihara, K; Ikeda, T; Ishikawa, M; Iwabuchi, H; Kazui, M; Kobayashi, H; Kurihara, A; Okazaki, O; Tanaka, N1
April, JH; Ernest, CS; Farid, NA; Li, YG; Ni, L; Payne, CD; Rohatagi, S; Small, DS; Winters, KJ1
Hagihara, K; Ikeda, T; Kazui, M; Kubota, K; Kurihara, A1
Fusegawa, K; Hagihara, K; Ikeda, T; Ikenaga, H; Izumi, T; Kazui, M; Kurihara, A; Nanba, T1
Hande, A; Kumar Jha, C; Lukram, O; Parmar, S; Tomar, KS; Zarapkar, M1
Amore, C; Dell'Elba, G; Di Santo, A; Evangelista, V; Martelli, N; Piccoli, A; Totani, L1

Trials

5 trial(s) available for thiophenes and r-138727

ArticleYear
Stereoselective metabolism of prasugrel in humans using a novel chiral liquid chromatography-tandem mass spectrometry method.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:6

    Topics: Chromatography, High Pressure Liquid; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stereoisomerism; Tandem Mass Spectrometry; Thiophenes

2007
The disposition of prasugrel, a novel thienopyridine, in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:7

    Topics: Administration, Oral; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cysteine; Feces; Humans; Hydrolysis; Intestinal Absorption; Male; Methylation; Molecular Structure; Oxidation-Reduction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Pyridines; Reference Values; Tandem Mass Spectrometry; Thiophenes

2007
Effect of age on the pharmacokinetics and pharmacodynamics of prasugrel during multiple dosing: an open-label, single-sequence, clinical trial.
    Drugs & aging, 2009, Volume: 26, Issue:9

    Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aging; Aspirin; Bleeding Time; Body Mass Index; Confidence Intervals; Drug Therapy, Combination; Fasting; Female; Humans; Least-Squares Analysis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Statistics, Nonparametric; Tablets, Enteric-Coated; Thiophenes; Young Adult

2009
The pharmacokinetics and pharmacodynamics of prasugrel in healthy Chinese, Japanese, and Korean subjects compared with healthy Caucasian subjects.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:2

    Topics: Adenosine Diphosphate; Adult; Aged; Asian People; Body Mass Index; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Statistics as Topic; Thiophenes; White People; Young Adult

2010
Integrated analysis of pharmacokinetic data across multiple clinical pharmacology studies of prasugrel, a new thienopyridine antiplatelet agent.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:3

    Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Aged, 80 and over; Biotransformation; Body Weight; Female; Half-Life; Humans; Male; Middle Aged; Models, Biological; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Young Adult

2011

Other Studies

14 other study(ies) available for thiophenes and r-138727

ArticleYear
Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor.
    Thrombosis and haemostasis, 2005, Volume: 94, Issue:3

    Topics: Animals; Binding, Competitive; Blood Platelets; CHO Cells; Cricetinae; Cricetulus; Cyclopropanes; Dose-Response Relationship, Drug; Humans; Membrane Proteins; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Time Factors; Transfection

2005
The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin.
    Thrombosis and haemostasis, 2007, Volume: 98, Issue:1

    Topics: Adenosine Diphosphate; Adult; Aspirin; Biomarkers; Blood Cells; Calcium; Cells, Cultured; Female; Humans; Inflammation; Kinetics; Male; Middle Aged; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Thrombosis; Up-Regulation

2007
The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities.
    Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:2

    Topics: Adenosine Diphosphate; Annexin A5; Biotransformation; Blood Coagulation Factors; Blood Platelets; Clot Retraction; Collagen; Humans; Monocytes; Phosphatidylserines; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Thrombelastography; Thrombin; Thromboplastin

2008
The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses.
    Platelets, 2008, Volume: 19, Issue:2

    Topics: Adenosine Monophosphate; Adult; Annexin A5; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytoplasmic Granules; Humans; In Vitro Techniques; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine

2008
Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor.
    Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:11

    Topics: Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cysteine; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Transduction, Genetic

2008
Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine.
    Drug metabolism and pharmacokinetics, 2008, Volume: 23, Issue:6

    Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Oxidoreductases, N-Demethylating; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticlopidine

2008
Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs.
    Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:3

    Topics: Animals; Area Under Curve; Clopidogrel; Cytochrome P-450 Enzyme System; Dogs; Hydrolysis; Male; Molecular Structure; Oxidation-Reduction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine

2009
Population pharmacokinetic analyses to evaluate the influence of intrinsic and extrinsic factors on exposure of prasugrel active metabolite in TRITON-TIMI 38.
    Journal of clinical pharmacology, 2009, Volume: 49, Issue:8

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Body Weight; Clinical Trials, Phase III as Topic; Female; Humans; Linear Models; Male; Middle Aged; Models, Biological; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Randomized Controlled Trials as Topic; Thiophenes

2009
Prediction of prasugrel active metabolite concentrations from 2 downstream inactive metabolite concentrations using multilinear regression analysis.
    Journal of clinical pharmacology, 2009, Volume: 49, Issue:8

    Topics: Adolescent; Adult; Aged; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Female; Humans; Linear Models; Male; Middle Aged; Models, Biological; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Thiophenes; Young Adult

2009
Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:6

    Topics: Biotransformation; Humans; Nitrobenzoates; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Sulfhydryl Compounds; Thiophenes

2010
Glutaredoxin and thioredoxin can be involved in producing the pharmacologically active metabolite of a thienopyridine antiplatelet agent, prasugrel.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Antibodies, Monoclonal; Biotransformation; Blotting, Western; Chromatography, Gel; Cytosol; Glutaredoxins; Glutathione; Humans; In Vitro Techniques; Liver; Microsomes, Liver; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Tandem Mass Spectrometry; Thiophenes; Thioredoxins

2011
The intestine as an important contributor to prasugrel active metabolite formation in vivo.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:4

    Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Dogs; Humans; Hydrolysis; Intestinal Mucosa; Liver; Male; Microsomes; Microsomes, Liver; Oxidation-Reduction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes

2011
Electrospray ionization LC-MS/MS validated method for the determination of the active metabolite (R-138727) of prasugrel in human plasma and its application to a bioequivalence study.
    Drug testing and analysis, 2012, Volume: 4, Issue:2

    Topics: Adolescent; Adult; Chromatography, Liquid; Humans; Linear Models; Male; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Thiophenes; Young Adult

2012
Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse.
    Thrombosis and haemostasis, 2012, Volume: 107, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biomarkers; Blood Platelets; Disease Models, Animal; Down-Regulation; Humans; Inflammation Mediators; Leukocytes; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Piperazines; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Selenoprotein P; Shock, Septic; Thiophenes; Thromboxane B2; Tumor Necrosis Factor-alpha

2012