thiophenes has been researched along with pyrimidine in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| MAEDA, T; SAIKAWA, I | 1 |
| Enkvist, E; Kadak, G; Kriisa, M; Raidaru, G; Roben, M; Uri, A | 1 |
| Ai, J; Chen, Y; Gao, X; Geng, M; Wang, Y; Zhang, A; Zhao, A | 1 |
| Li, Y; Ma, Z; Wang, F; Wang, J; Wang, Y | 1 |
| Andrei, G; Balzarini, J; Johnson, C; Krishnamoorthy, P; Seley-Radtke, KL; Snoeck, R; Wauchope, OR | 1 |
| Guan, X; Morris, ME; Ruszaj, D | 1 |
| Kumar, N; Mishra, I; Mishra, R; Sachan, N | 1 |
| Chu, C; Li, X; Xiao, Z; Xu, S; Yang, Z; Yu, L; Zhang, Q; Zheng, P; Zhou, L; Zhou, Z; Zhu, W | 1 |
| Du, S; Li, HX; Li, WY; Lu, XH; Ma, Y; Ma, YC; Wang, RL; Zhou, L | 1 |
| Jaswal, S; Kumar, S; Monga, V; Rulhania, S | 1 |
| Jakubowski, M; Jarzęcki, AA; Kaszuba, A; Sitkowski, J; Wojtczak, A; Łakomska, I | 1 |
2 review(s) available for thiophenes and pyrimidine
| Article | Year |
|---|---|
A Review on Anticancer Activities of Thiophene and Its Analogs.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Neoplasms; Pyrimidines; Structure-Activity Relationship; Thiophenes | 2020 |
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.
Topics: Acetazolamide; Animals; Antineoplastic Agents; Antioxidants; Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Indoles; Isatin; Molecular Docking Simulation; Organoselenium Compounds; Oxadiazoles; Protein Binding; Protein Isoforms; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Thiazines; Thiophenes; Urea | 2021 |
10 other study(ies) available for thiophenes and pyrimidine
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
[STUDIES ON NITROFURAN AND RELATED COMPOUNDS FOR MEDICINAL PURPOSE. VII. SYNTHESES OF 2-(SUBSTITUTED AMINO)PYRIMIDINE DERIVATIVES WITH NITROFURAN NUCLEUS AND THEIR STRUCTURE-ACTIVITY RELATIONSHIP].
Topics: Chemistry, Pharmaceutical; Escherichia coli; Nitrofurans; Pharmacology; Pharmacy; Pyrimidines; Research; Staphylococcus; Structure-Activity Relationship; Thiophenes | 1964 |
Effect of the structure of adenosine mimic of bisubstrate-analog inhibitors on their activity towards basophilic protein kinases.
Topics: Adenosine; Arginine; Binding Sites; Cyclic AMP-Dependent Protein Kinases; Peptides; Protein Binding; Protein Kinase Inhibitors; Pyrimidines; rho-Associated Kinases; Thiophenes | 2009 |
Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold.
Topics: Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Glioblastoma; Humans; Mice; Mice, Nude; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrimidines; Structure-Activity Relationship; Thiophenes; Transplantation, Heterologous | 2011 |
Structural requirements of pyrimidine, thienopyridine and ureido thiophene carboxamide-based inhibitors of the checkpoint kinase 1: QSAR, docking, molecular dynamics analysis.
Topics: Binding Sites; Checkpoint Kinase 1; Hydrogen Bonding; Molecular Dynamics Simulation; Protein Conformation; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Pyrimidines; Quantitative Structure-Activity Relationship; Thiophenes | 2012 |
Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues.
Topics: Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Guanosine; HeLa Cells; Humans; Imidazoles; Purine Nucleosides; Pyrimidines; Thiophenes; Virus Replication | 2012 |
Development and validation of a liquid chromatography tandem mass spectrometry assay for AZD3965 in mouse plasma and tumor tissue: Application to pharmacokinetic and breast tumor xenograft studies.
Topics: Acetonitriles; Animals; Atmospheric Pressure; Breast Neoplasms; Cell Line, Tumor; Chromatography, Liquid; Female; Heterografts; Mice; Plasma; Pyrimidines; Pyrimidinones; Reproducibility of Results; Tandem Mass Spectrometry; Thiophenes; Uracil | 2018 |
Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations.
Topics: Antineoplastic Agents; Cell Line, Tumor; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Drug Design; ErbB Receptors; Humans; Mutation; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship; Thiophenes | 2020 |
Scaffold-based selective SHP2 inhibitors design using core hopping, molecular docking, biological evaluation and molecular simulation.
Topics: Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Principal Component Analysis; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyrimidines; Structure-Activity Relationship; Thiophenes | 2020 |
Factors Affecting the Stability of Platinum(II) Complexes with 1,2,4-Triazolo[1,5-
Topics: Antineoplastic Agents; Benzene Derivatives; Cell Line, Tumor; Oxides; Platinum; Pyrimidines; Sulfoxides; Thiophenes; Triazoles | 2022 |