thiophenes has been researched along with piperidines in 337 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 163 (48.37) | 18.7374 |
| 1990's | 17 (5.04) | 18.2507 |
| 2000's | 89 (26.41) | 29.6817 |
| 2010's | 61 (18.10) | 24.3611 |
| 2020's | 7 (2.08) | 2.80 |
| Authors | Studies |
|---|---|
| Himeno, S; Hosono, T; Saito, R; Tohei, N; Yoshinaga, T | 1 |
| Borchgrevink, CF; Lunde, I | 1 |
| Horak, F; Hussarek, M | 1 |
| Göbel, P | 1 |
| Meshi, T; Tamaki, H | 3 |
| Martin-du-Pan, R | 1 |
| Alise, G; Apolito, A; Lampa, E; Pedone, P; Russo, G | 1 |
| Debelic, M; Radielovic, P; Wuethrich, B | 1 |
| Radielovic, P; Wüthrich, B | 1 |
| Dicsó, F; Dolinay, T; Hankovszky, E | 1 |
| Frank, A | 1 |
| Martin, U; Römer, D | 1 |
| Hartmann, V; Holle, JP; Magnussen, H | 1 |
| Beumer, HM | 1 |
| Aas, K | 1 |
| Lykkegaard Nielsen, EA; Osterballe, O | 1 |
| Mattson, K; Nikander-Hurme, R; Poppius, H | 1 |
| Hurme, R; Mattson, K; Poppius, H | 1 |
| Craps, L; Martin, U; Radielovic, P | 1 |
| Martin, U; Roemer, D | 1 |
| Kumagai, A; Tomioka, H | 1 |
| Kumagai, A; Tanaka, M; Tomioka, H; Yoshida, S | 1 |
| Deriugin, IL; Gushchin, IS | 1 |
| Lamont, H; Pauwels, R; Van Der Straeten, M | 1 |
| Craps, L; Greenwood, C; Radielovic, P | 1 |
| Haahtela, T | 1 |
| Gmür, H; Scherrer, M | 1 |
| Taylor, B; Wells, A | 1 |
| Wüthrich, B | 1 |
| Crowder, D; Greenwood, CD | 1 |
| Fryda-Kaurimsky, Z; Giesen, HK | 1 |
| Holmgren, EB; Jonsson, M | 1 |
| Kuokkanen, K | 1 |
| Medici, TC; Radielovic, P | 1 |
| Cuevas, M; Girard, JP | 1 |
| Ford, R; Taylor, B | 1 |
| Hlinka, V; Labus, J | 1 |
| Dolezalová, K | 1 |
| Sugihara, J; Taga, N | 1 |
| Saito, K; Tamaki, H | 1 |
| Bonnekoh, B; Hegemann, L; Mahrle, G; Wevers, A | 1 |
| Bouysset, F; Laubie, M; Schmitt, H; Vayssettes-Courchay, C; Verbeuren, TJ | 1 |
| Durani, S; Kapil, RS; Saeed, A; Sharma, AP | 1 |
| Boundy, V; Komm, BS; Lyttle, CR; Sundstrom, SA; Xu, Q | 1 |
| Kienast, J; Verstraete, M | 1 |
| Dlohozková, N; Metys, J; Soucek, R; Valchár, M | 1 |
| Accornero, N; Agnoli, A; Casacchia, M; Ruggieri, S; Volante, F | 1 |
| Rao, KK | 1 |
| Nelson, RF | 1 |
| Pfeifer, Y; Polishuk, WZ; Sadovsky, E; Sulman, FG; Weinstein, D | 1 |
| Dessouky, YM; Mousa, BA; Nour el-Din, HM | 1 |
| Carroll, PR; Ebeling, PW; Glover, WE | 1 |
| Boyd, JE; Sommerville, RG | 1 |
| Rozenberg, MC; Walker, CM | 1 |
| Damas, J | 1 |
| De Cañete, F; Moreno Quesada, A; Salido Sánchez, A; Sillero, J | 1 |
| Poch, GF | 1 |
| Anthony, M; Lance, JW | 1 |
| Avery, GS; Speight, TM | 1 |
| Bennert, C; Berger, E; Jäger, W; Kauschmann, R; Kutschera, J; Pietsch, U; Riese, W; Wendeberg, H | 1 |
| Dora, A; Pfeifer, Y; Polishuk, WZ; Rahamimoff, E; Sadovsky, E; Sulman, FG | 1 |
| Harigaya, S; Kiyomoto, A; Murata, S; Tamaki, H; Tanaka, M | 1 |
| Forssman, B; Henriksson, KG; Kihlstrand, S | 1 |
| Jorgensen, RS | 2 |
| DeYoung, DW; Paddleford, RR; Short, CE | 1 |
| Hübbe, P | 1 |
| Andersson, PG | 1 |
| Klapetek, J | 3 |
| Zwozdziak, W | 1 |
| Ackles, KN; Inwood, MJ; Philp, RB; Radomski, MW | 1 |
| Rossi, MV; Westermann, P | 1 |
| Figar, S; Janský, M; Starý, O; Stein, J | 1 |
| Antoncić, N; Ledić, P; Sepcić, J | 1 |
| Tsougranis, A | 1 |
| Sjaastad, O; Stensrud, P | 1 |
| Klimek, A; Prusiński, A | 1 |
| Dalsgaard-Nielsen, T; Ulrich, J | 1 |
| Wasilewski, R | 1 |
| Kanno, T; Meshi, T; Nakamura, S | 1 |
| Fjalland, B; Lassen, N; Nielsen, IM; Pedersen, V; Petersen, PV | 1 |
| Ishikawa, M; Nagasaki, A; Takagi, K; Takahashi, T; Yamagata, S | 1 |
| Gastpar, H | 1 |
| Niewodniczy, A; Prusiński, A | 1 |
| Bondesson, G; Dafgård, B; Gronowitz, S; Magnusson, O; Stjernström, NE | 1 |
| Nüesch, E; Ohnhaus, EE | 1 |
| Marcos Lanzarot, M | 1 |
| Arthur, GP; Hornabrook, RW | 1 |
| Ackermann, W; Martin-duPan, R | 1 |
| Foster, JB; Hughes, RC | 1 |
| Kotwica, S; Prusiński, A; Rydzewski, W; Zawadzki, Z | 1 |
| Kamegawa, M; Kusumoto, H; Mori, Y; Nishimura, N; Tanimoto, H | 1 |
| Hole, K | 1 |
| Haarmann, K; Müller, KH; Neff, K | 1 |
| Barolin, GS | 1 |
| Brügger, A | 1 |
| Anthony, M; Lance, JW; Somerville, B | 1 |
| Bosin, TR; Campaigne, E | 1 |
| Droszcz, W | 1 |
| Dyson, AJ; Mackay, AD | 1 |
| Magnussen, H | 1 |
| Borelli, S; Düngemann, H; Schiess, W | 1 |
| Furlan, J; Janezic, A; Stangl, B; Ustar, M | 1 |
| Clarke, CW; May, CS | 1 |
| Gutová, M; Hlousek, Z; Hlousková, Z | 1 |
| Czerniawska-Mysik, G; Kuklinski, P; Serwonska, M; Szczeklik, A | 2 |
| Chachaj, W; Kraus-Filarska, M; Liebhart, E; Liebhart, J; Małolepszy, J; Panaszek, B | 1 |
| Alise, G; Campidonico, U; Cantone, F; Mazzeo, V; Scognamiglio, A; Somma, A; Visone, C | 1 |
| Jeffreys, DB; Volans, GN | 1 |
| Daniliak, IG; Gavrilov, VN; Komarov, FI; Tsvetkova, OA | 1 |
| Baggiolini, M; Martin, U | 1 |
| Schmidt, OP | 1 |
| Klein, G; Matthys, H; Urbanek, R | 1 |
| Dolecek, R | 1 |
| Radermecker, M | 1 |
| Jordan, VC | 1 |
| Goda, Y; Harada, H; Kimura, I; Sasaki, Y; Takahashi, K; Tanizaki, Y | 1 |
| Green, LR; Newboult, E; Valcaccia, B; Wakeling, AE | 1 |
| Valcaccia, B; Wakeling, AE | 1 |
| Craps, L | 1 |
| Graff-Lonnevig, V; Kusoffsky, E | 2 |
| Kumagai, A; Muranaka, M; Shida, T; Takahashi, T; Tomioka, H | 1 |
| Chazan, R; Droszcz, W; Garlicki, A; Lech, B; Madalińska, M; Piotrowska, B | 1 |
| von Wichert, P | 1 |
| Lane, DJ; Morris, MJ | 1 |
| Ackermans, F; Lamarre, A; Lapierre, JG; Vincke, P | 1 |
| Ahonen, A; Haahtela, T; Hurme, R; Maasilta, P; Mattson, K; Muittari, A; Poppius, H; Venho, K | 2 |
| Davies, RJ; Ollier, S; Phillips, MJ | 1 |
| Adamek-Guzik, T; Czerniawska-Mysik, G; Koterba, A; Szczeklik, A; Wołoszynski, J | 1 |
| Borel, JF | 1 |
| Clay, MJ; Hasham, F; Jones, RS; Kennedy, JD | 1 |
| Lane, DJ | 1 |
| Cameron, E | 1 |
| Hamm, M; Klein, G; Matthys, H; Urbanek, R | 1 |
| Elmes, J; Tanser, AR | 1 |
| Zavázal, V | 1 |
| Sarsfield, JK | 1 |
| Schachoff, R; Stemmann, EA; Weihermann, D | 1 |
| Harigaya, S; Narikawa, H; Oyama, R | 1 |
| Schubotz, R | 1 |
| Groggins, RC; Hiller, EJ; Milner, AD; Stokes, GM | 1 |
| Farina, JC; Grimm, R; Krupp, P | 1 |
| Klein, G; Urbanek, R | 1 |
| Saihan, EM | 1 |
| Matthys, H | 1 |
| Sherriff, JM | 1 |
| Spiro, SG | 1 |
| Medici, TC; Radielovic, P; Steiner, A | 1 |
| Spicak, V | 1 |
| Lowe, DA; Richardson, BP | 1 |
| Maclay, WP | 1 |
| Ferencíková, J; Michalicka, D; Papp, I; Ratajová, V; Zajdlíková, E | 1 |
| Magaribuchi, T; Nakajima, H; Takenaga, H | 1 |
| Bergstrom, DA; Gonzalez, AM; Huang, KX; Kreiss, DS; Sibley, DR; Walters, JR | 1 |
| Furukawa, T; Katsuragi, T; Soejima, O | 1 |
| Hegemann, L; Kempenaar, J; Ponec, M | 1 |
| Dawson, GR; Iversen, SD | 1 |
| Culberson, C; Darke, PL; Duong, TT; Ghosh, AK; Holloway, MK; Lee, HY; McKee, SP; Munson, PM; Smith, AM; Thompson, WJ | 1 |
| Burcham, DL; Huang, SM; Quon, CY; Wong, YN | 1 |
| Hashimoto, A; Maeda, M; Nishikawa, T; Orita, K; Sasaki, S; Umezu, K; Yugami, T | 1 |
| Chicheportiche, R; Crouzel, C; Hantraye, P; Kamenka, JM; Ponchant, M; Varastet, M | 1 |
| Bryan, N; Zuckerman, SH | 1 |
| Bégos, A; Bizot, JC; Breton, P; Brochet, D; Tambuté, A; Trovero, F | 1 |
| Adrian, MD; Bryant, HU; Rowley, E; Sato, M; Turner, CH; Wang, T | 1 |
| Rowley, E; Sato, M; Turner, CH; Zeng, GQ | 1 |
| Dekeyne, A; Girardon, S; Millan, MJ | 1 |
| Komiya, I; Okudaira, N; Speirs, GC; Sugiyama, Y; Tatebayashi, T | 1 |
| Ishida, H; Ishikawa, Y; Skowronski, MT | 1 |
| Diaugustine, RP; Hewitt, SC; Klotz, DM; Korach, KS | 1 |
| Komiya, I; Okudaira, N; Sugiyama, Y | 1 |
| Galid, A; Kubista, E; Seifert, M | 1 |
| Hurn, PD; Murphy, SJ; Rossberg, MI; Traystman, RJ | 1 |
| Asai, F; Iwamura, R; Koike, H; Ogawa, T; Otsuguro, K; Sugidachi, A; Yoneda, K | 1 |
| Booser, D; Buzdar, A; Dhingra, K; Enas, N; Hudis, C; Major, M; Melemed, A; Münster, PN; Ni, L; Norton, L; Seidman, A; Theriault, R | 1 |
| Neubauer, BL; Raghow, S; Steiner, MS | 1 |
| Bleakman, D; Gates, MR; Grabell, J; Gupta, A; Ho, K; Jarvie, KR; Miu, P; Ogden, A; Ornstein, PL; Peters, D; Radhakrishnan, V; Zarrinmayeh, H; Zimmerman, DM | 1 |
| Bond, A; Huff, K; Lodge, D; Vandergriff, J | 1 |
| Beach, TG; Fisher, A; Potter, PE; Sue, LI; Walker, DG | 1 |
| Bentrem, D; Dardes, RC; De Los Reyes, A; Jordan, VC; Lee, ES; O'Regan, RM; Schafer, JM | 1 |
| Apostolova, MD; Chakrabarti, S; Chen, S; Cherian, MG | 1 |
| Bryant, HU; Burris, LL; Glasebrook, AL; Palkowitz, AD; Pearce, HL; Peer, C; Sporn, MB; Starling, JJ; Suh, N; Wang, Y; Williams, C | 1 |
| Bentrem, D; Dardes, RC; Jordan, VC; O'Regan, RM; Schafer, JM | 1 |
| Fabian, CJ; Kimler, BF | 1 |
| Elit, L; Hirte, H | 1 |
| Gajdos, C; Jordan, VC | 1 |
| Bethea, CL; Michelson, D; Mirkes, SJ; Su, A | 1 |
| Biskobing, DM; Downs, R; Novy, AM | 1 |
| Chan, S | 2 |
| Cox, DA; Hurn, PD; Littleton-Kearney, MT; Ostrowski, NL; Rossberg, MI | 1 |
| Farris, MR; Glasebrook, AL; Grese, TA; Heyman, RA; Lamph, WW; Palkowitz, AD; Risingsong, R; Sporn, MB; Suh, N; Williams, CR | 1 |
| Beachy, PA; Chen, JK; Maiti, T; Taipale, J; Young, KE | 1 |
| Bryant, HU; Jee, WS; Ma, YL; Palkowitz, A; Sato, M; Turner, CH; Zeng, Q | 1 |
| Baronti, R; Calvani, M; Camaioni, E; Chiarugi, A; Costantino, G; Marinozzi, M; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Pellicciari, R; Picca, R | 1 |
| Booser, DJ; Buzdar, A; Hudis, C; Jones, SE; Melemed, AS; Munster, PN; O'Shaughnessy, JA; Peterson, P; Pippen, JE; Winer, E | 1 |
| Lüscher, TF; Spieker, LE | 1 |
| Cunningham, KA; Filip, M; McCreary, AC | 1 |
| Ducreux, M; Köhne, CH; Schwartz, GK; Vanhoefer, U | 1 |
| Bloss, J; Buller, R; Burke, T; Fowler, J; Gordon, A; McMeekin, DS; Melemed, A; Sabbatini, P | 1 |
| Burke, TW; Walker, CL | 1 |
| Baselga, J; Bellet, M; Carrasco, E; Enas, N; Guillem-Porta, V; Kayitalire, L; Kerbrat, P; Krejcy, K; Kuta, M; Llombart-Cussac, A; Lluch, A; Namer, M; Petruzelka, L; Vodvarka, P | 1 |
| DeGregorio, MW; Marchisano-Karpman, C | 1 |
| CHAPPEL, CI; VONSEEMANN, C | 1 |
| BIEL, JH; HOYA, WK; LEISER, HA; MITCHELL, TF; ROBERTSON, JE | 1 |
| KINNEAR, DG | 1 |
| Bar-Ner, N; Brandeis, R; Egozi, I; Fisher, A; Haring, R; Kliger-Spatz, M; Marcovitch, I; Natan, N; Pittel, Z; Sonego, H | 1 |
| Fried, A; Segev, E; Wientroub, S; Zeitlin, L | 1 |
| Licun, W; Tannock, IF | 1 |
| A'Hern, R; Detre, S; Dowsett, M; Johnston, SR; Riddler, S; Salter, J | 1 |
| Tomioka, K; Yamada, K; Yamashita, M | 1 |
| Bartholomaeussen, M; Freddie, CT; Larsen, SS; Lykkesfeldt, AE | 1 |
| Berchuck, A; Heyman, RA; Krajewski, S; Lamph, WW; Liby, K; Reed, JC; Rendi, MH; Risingsong, R; Royce, DB; Sporn, MB; Suh, N; Williams, CR | 1 |
| Christensen, GL; Freddie, CT; Lykkesfeldt, AE | 1 |
| Sporn, MB | 1 |
| Albain, KS; Anderson, J; Arneson, DW; Bacus, JW; Beenken, SW; Browne, D; Budd, GT; Burak, WE; Fabian, CJ; Fruehauf, JP; Ganz, PA; Grizzle, WE; Hyams, DM; Johnson, KA; Kimler, BF; Lagios, MD; Mayo, MS; O'Shaughnessy, JA; Sauter, ER; Tawfik, OW | 1 |
| Hede, K | 1 |
| Bolton, JL; Liu, H; Liu, J; Thatcher, GR; van Breemen, RB | 1 |
| David, E; Fournier dit Chabert, J; Lemaire, M; Pellet-Rostaing, S; Perrin, J | 1 |
| Ishiwata, K; Jonker, JW; Kojima, M; Kondo, C; Kusuhara, H; Okudaira, N; Onuki, R; Sugiyama, Y; Suzuki, H; Suzuki, M | 1 |
| Johansen, AM | 1 |
| Grandoso, L; Pineda, J; Torrecilla, M; Ugedo, L | 1 |
| Hamon, M; Le Bihan, C; Loiseau, F; Thiébot, MH | 1 |
| Baronti, R; Meli, E; Moroni, F; Pangallo, M; Pellegrini-Giampietro, DE; Picca, R | 1 |
| Asai, F; Hasegawa, M; Isobe, T; Jakubowski, JA; Ogawa, T; Sugidachi, A | 1 |
| Tannock, IF; Wu, L | 1 |
| Munster, PN | 1 |
| Bolton, JL; Liu, H; Thatcher, GR | 1 |
| Hariguchi, N; Hirai, S; Horoiwa, S; Kasahara, R; Kikuchi, H; Matsumoto, M; Oshima, Y; Yamamoto, K | 1 |
| Kopjar, N; Petek, MJ; Radić, B; Vrdoljak, AL; Zeljezić, D | 1 |
| Brown, P; Kim, H; Krajewski, S; Labrie, F; Lamph, W; Liby, K; Rendi, M; Risingsong, R; Royce, DB; Sporn, MB; Suh, N; Williams, CR; Xu, X | 1 |
| Bloomquist, JR; Geldenhuys, WJ; Malan, SF; Van der Schyf, CJ | 1 |
| Barratt, ML; Smith, K | 1 |
| Abdel-Maksoud, AA; Carpino, LA; Ionescu, D; Mansour, EM; Zewail, MA | 1 |
| Beyer, CE; Hughes, ZA; Kerns, EH; Lin, Q; Zhang, MY | 1 |
| Bolton, JL; Chandrasena, RE; Kastrati, I; Liu, H; Petukhov, PA; Qin, Z; Thatcher, GR; Yao, P | 1 |
| Park, A | 1 |
| Bolton, JL; Liu, H; Qin, Z; Thatcher, GR | 1 |
| Mukherjee, A; Mukherjee, S; Mullick, S; Nagar, S; Saha, A | 1 |
| Asghodom, RT; Bolton, JL; Frasor, J; Kastrati, I; Lantvit, DD; Overk, CR; Peng, KW; Qin, Z; Thatcher, GR | 1 |
| Altamura, M; Catalioto, RM; Fedi, V; Giannotti, D; Giolitti, A; Giuliani, S; Guidi, A; Harmat, NJ; Lecci, A; Maggi, CA; Meini, S; Nannicini, R; Pasqui, F; Tramontana, M; Triolo, A | 1 |
| Bolton, JL; Dietz, BM; Dunlap, T; Kastrati, I; Lantvit, DD; Overk, CR; Qin, Z; Thatcher, GR; Yao, P; Yu, B | 1 |
| Buzdar, AU; Deshmane, V; Krishnamurthy, S; Melemed, AS; Peterson, P | 1 |
| Ohta, H | 1 |
| Berend, S; Kopjar, N; Mladinić, M; Petek, MJ; Radić, B; Vrdoljak, AL; Zeljezić, D | 1 |
| Abe, M; Fukushima-Shintani, M; Hirayama, F; Iwatsuki, Y; Kawasaki, T; Sugasawa, K; Suzuki, K | 1 |
| Chang, CP; Chao, YS; Chiu, HH; Chu, CM; Chung, WL; Hsieh, WP; Hung, MS; Kuo, CW; Lin, Y; Shia, KS; Song, JS; Tai, CL; Tseng, SL; Tung, YS; Wu, CH | 1 |
| Diaz, JL; Holenz, J; Oberdorf, C; Schepmann, D; Vela, JM; Wünsch, B | 1 |
| Eisenach, JC; Hayashida, K | 1 |
| Bellucci, F; Catalani, C; Cucchi, P; Giolitti, A; Giuliani, S; Meini, S; Santicioli, P | 1 |
| Bolton, JL; Edirisinghe, P; Qin, Z; Thatcher, GR; Wijewickrama, GT; Yu, B | 1 |
| Alam, J; Bolognese, M; Broy, S; Feldman, R; Krege, JH; Lakshmanan, M; Meats, DL; Omizo, M; Utian, WH | 1 |
| Ahn, K; Beidler, D; Cravatt, BF; Dunbar, JB; Fay, L; Gregory, T; Johnson, DS; Kesten, S; Lazerwith, SE; Liimatta, M; Morris, M; Nomanbhoy, TK; Smith, S; Song, Y; Stiff, C | 1 |
| Jalink, K; Mancini, MA; Michalides, R; Neefjes, J; Rondaij, M; Sharp, ZD; Zwart, W | 1 |
| Fairlamb, AH; Frearson, JA; Gilbert, IH; Jones, DC; Patterson, S; Shanks, EJ; Wyatt, PG | 1 |
| Cox, DA; Downs, RW; Dowsett, SA; Ghosh, A; Harper, K; Moffett, AM | 1 |
| Bolton, JL; Lu, M; Peng, KW; Qin, Z; Thatcher, GR; Wang, H; Wang, Z; Wijewickrama, GT | 1 |
| Ashwell, S; Brassil, PJ; Dai, J; Garner, CE; Gönen, M; Goteti, K; Kern, SE; Moustakas, DT; Schwartz, GK; Utley, L; Zabludoff, S | 1 |
| Kristie, TM; Liang, Y; Narayanan, A; Peng, H; Vogel, JL | 1 |
| Lewiecki, EM | 1 |
| Hosokawa, R; Iida, T; Inagaki, T; Inenaga, K; Ono, K | 1 |
| Mrsić, G; Petek, MJ; Vrdoljak, AL | 1 |
| Silverman, SL | 1 |
| Amewou-Atisso, M; Christiansen, C; Cox, D; Cummings, SR; McClung, M; Miller, P; Mitlak, B; Powles, T; Reginster, JY; Stock, J; Zanchetta, J | 1 |
| Colucci, M; Di Giannuario, A; Maione, F; Mascolo, N; Mastriota, M; Palmery, M; Perretti, M; Pieretti, S; Severini, C | 1 |
| Dotterer, SK; Forbes, RA; Hammill, CL | 1 |
| Powles, T | 1 |
| Alam, J; Cox, DA; Dowsett, SA; Kendler, DL; Palacios, S; Stock, J; Zanchetta, J | 1 |
| Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H | 1 |
| Bradbury, BJ; Deshpande, M; Phadke, AS; Pucci, MJ; Thanassi, JA; Wiles, JA | 1 |
| Christman, JW; van Breemen, RB; Xiao, L; Yu, R; Zhao, G | 1 |
| Alam, J; Bhattoa, HP; Cox, DA; Dowsett, SA; Goldstein, SR; Muram, D; Neven, P; Sipos, A | 1 |
| Bertrand, D; Bertrand, S; Boess, FG; Chesworth, R; Flood, DG; Gawryl, M; Hilt, D; König, G; Methfessel, C; Prickaerts, J; Reneerkens, OA; Shapiro, G; van Goethem, NP | 1 |
| Bolton, JL; Chandrasena, ER; Choi, J; Edirisinghe, PD; Hemachandra, LP; Kastrati, I; Thatcher, GR; Wang, YT | 1 |
| Chines, AA; Komm, BS | 1 |
| Barraza, SJ; Blakely, PK; Bolduc, KL; Irani, DN; Keep, RF; Larsen, SD; Miller, DJ; Sindac, JA; Yestrepsky, BD | 1 |
| Agnusdei, D; Amewou-Atisso, M; Cox, DA; Cummings, SR; Diem, SJ; Dowsett, SA; Fabian, CJ; Muram, D; Neven, P; Powles, TJ; Wickerham, DL | 1 |
| Buschmann, H; Holenz, J; Oberdorf, C; Schepmann, D; Vela, JM; Wünsch, B | 1 |
| Lazzari, P; Mastinu, A; Pani, L; Pinna, GA; Pira, M | 1 |
| Feng, Z; Hou, T; Li, Y | 1 |
| Cuzick, J; Sestak, I | 1 |
| Calaf Alsina, J; Coronado Martín, PJ | 1 |
| Bechi, P; Catalani, C; Giuliani, S; Maggi, CA; Meini, S; Riccadonna, S; Ringressi, MN; Santicioli, P | 1 |
| Alsaid, MS; El-Gazzar, MG; Ghorab, MM | 1 |
| Fijał, K; Nikiforuk, A; Popik, P | 1 |
| Abdelhamid, R; Bennett, BM; Choi, J; Larson, J; Luo, J; Piyankarage, S; Qin, Z; Thatcher, GR; VandeVrede, L | 1 |
| Han, J; Hu, L; Li, H; Liu, Y; Pei, M; Zhang, G | 1 |
| Caballero, A; Cass, DK; Flores-Barrera, E; Thomases, DR; Tseng, KY; Vital, WF | 1 |
| Bolton, JL; Chandrasena, RE; Choi, J; Hemachandra, LP; Michalsen, BT; Patel, H; Piyankarage, SC; Scism, RA; Siklos, MI; Thatcher, GR; Thayer, EN; Wang, S; Wang, Y; Xiong, R | 1 |
| Marchalín, Š; Šafář, P; Sivý, J; Vrábel, V | 1 |
| Chang, CP; Chao, YS; Chen, PH; Hsiao, WC; Hung, MS; Lin, Y; Shia, KS; Wang, YT; Wu, CH; Yeh, YN | 1 |
| Gwarek, M; Lübbert, H; Schmitz, B; Segelcke, D; Ullmer, C; Zhu, XR | 1 |
| Futamura, T; Hashimoto, K; Ishima, T; Kikuchi, T; Ohgi, Y; Yoshimi, N | 1 |
| Chen, L; Liu, D; Liu, Y; Tao, Z; Xia, G; Zhi, S | 1 |
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| Betz, M; Heine, A; Klebe, G; Rühmann, E | 1 |
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| Allen, MR; Bivi, N; Burr, DB; Chalmers, MJ; Chavali, B; Dodge, JA; Durst, GL; Hu, H; Reutter, CT; Riley, A; Sato, M | 1 |
| Burdette, JE; Davis, DA; Dean, M; Moyle-Heyrman, G; Schipma, MJ | 1 |
| Arantes, HP; Bilezikian, JP; Chiang, AY; Gimeno, SG; Lazaretti-Castro, M | 1 |
| Hirate, M; Kutoh, E; Murayama, T; Wada, A | 1 |
| Kantevari, S; Pulipati, L; Sriram, D; Yogeeswari, P | 1 |
| Ajmera, S; Bollinger, KA; Bridges, TM; Bubser, M; Chang, S; Chase, P; Conn, PJ; Duggan, ME; Emmitte, KA; Engers, JL; Gregro, AR; Han, C; Hodder, PS; Hopkins, CR; Jones, CK; Lamsal, A; Lindsley, CW; Melancon, BJ; Niswender, CM; Noetzel, MJ; Smith, E; Tarr, JC; West, M; Wood, MR; Wood, MW | 1 |
| Babayan, AH; Gall, CM; Hou, B; Kantorovich, S; Lynch, G; Wang, W | 1 |
| Carroll, FI; Decker, AM; Gichinga, MG; Kormos, CM; Mascarella, SW; Navarro, HA; Runyon, SP; Thomas, JB | 1 |
| Flood, DG; Jeggo, R; Koenig, G; Leventhal, L; Patzke, H; Townsend, M; van den Top, M; Walczak, JS; Whyment, A | 1 |
| Feng, Y; Jin, W; Li, H; Pan, H; Zhao, T; Zhao, Y | 1 |
| Lee, BH; Lee, JH; Lim, CJ; Oh, KS; Park, BK; Seo, HW; Yi, KY | 1 |
| Boeckxstaens, G; Camilleri, M | 1 |
| de Villiers, TJ | 1 |
| Alemán, C; Del Valle, LJ; Estrany, F; Micheletti, P; Puiggalí-Jou, A | 1 |
| Anderson, EC; Bian, Q; Brejc, K; King, DS; Kranzusch, PJ; Meyer, BJ; Preston, CG; Uzawa, S; Wheeler, BS | 1 |
| Benitex, Y; Bookbinder, M; Bristow, LJ; Keavy, D; King, D; Macor, JE; Morgan, DG; Olson, R; Polino, J; Signor, L; Weed, MR; Zaczek, R | 1 |
| Alaverdashvili, M; Laprairie, RB | 1 |
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| Bay-Jensen, AC; Hägglund, P; Karsdal, MA; Kayed, A; Kjelgaard-Petersen, CF; Mobasheri, A; Sharma, N; Thudium, CS | 1 |
| Hwang, CK; Kim, BJ; Kolomeyer, AM | 1 |
| Doebelin, C; Kamenecka, TM; Kuryatov, A; Leffler, A; Lindstrom, J; Norleans, J; Wang, J | 1 |
| Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S | 1 |
| Cao, X; Gu, J; Li, X; Liu, P; Miao, Y; Sun, D; Xu, Z; Zhang, J | 1 |
| Alamein, C; Canals, M; Christie, MJ; Connor, M; Fritzwanker, S; Gillis, A; Gondin, AB; Grimsey, NL; Halls, ML; Kassiou, M; Katte, TA; Kellam, B; Kliewer, A; Krasel, C; Lane, JR; Lim, HD; Manandhar, P; Reekie, T; Sanchez, J; Santiago, M; Schmiedel, F; Schulz, S | 1 |
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Yoshikawa, N; You, Q; Yu, B; Yu, CQ; Yu, H; Yu, HG; Yu, J; Yu, L; Yu, Q; Yu, X; Yu, Y; Yu, YK; Yu, Z; Yuan, Q; Yuan, R; Yuan, W; Yuan, X; Yuan, Y; Zager, RA; Zagozdzon, A; Zaller, N; Zang, YP; Zappi, ME; Zelikoff, JT; Zeman, T; Zhai, X; Zhan, P; Zhang, B; Zhang, C; Zhang, G; Zhang, H; Zhang, HB; Zhang, J; Zhang, JS; Zhang, L; Zhang, M; Zhang, Q; Zhang, RX; Zhang, S; Zhang, T; Zhang, W; Zhang, WH; Zhang, X; Zhang, XX; Zhang, Y; Zhang, YQ; Zhang, YW; Zhang, Z; Zhang, ZH; Zhao, D; Zhao, FL; Zhao, K; Zhao, L; Zhao, M; Zhao, R; Zhao, S; Zhao, W; Zhao, WG; Zhao, X; Zhao, Y; Zheng, G; Zheng, J; Zheng, S; Zheng, W; Zheng, Y; Zheng, YG; Zhong, Z; Zhou, C; Zhou, D; Zhou, H; Zhou, HY; Zhou, L; Zhou, Q; Zhou, X; Zhou, Y; Zhou, YL; Zhou, Z; Zhu, J; Zhu, L; Zhu, N; Zhu, X; Zhu, XF; Zhu, Y; Zhu, Z | 1 |
| Bu, ZL; Cao, Y; Fang, ZX; Lei, H; Liu, M; Liu, W; Wang, WW; Wang, YY; Wu, YL; Wu, YZ; Xiao, XH; Xu, HZ; Yu, M; Zhang, XM; Zhang, Y; Zhang, ZL | 1 |
| Cannavò, D; Caraci, F; Caruso, G; Drago, F; Leggio, GM; Salomone, S; Santagati, M | 1 |
| Gabrail, N; Smith, C | 1 |
| Higashi, Y; Kataoka, T; Miyake, Y; Nakao, A; Tanaka, Y; Tanigaki, R | 1 |
34 review(s) available for thiophenes and piperidines
| Article | Year |
|---|---|
[New aspects of long-term asthma therapy].
Topics: Adrenergic beta-Agonists; Adrenocorticotropic Hormone; Allergens; Asthma; Chronic Disease; Cromolyn Sodium; Desensitization, Immunologic; Drug Therapy, Combination; Glucocorticoids; Humans; Parasympatholytics; Piperidines; Theophylline; Thiophenes | 1979 |
Pharmacology of the interaction between platelets and vessel wall.
Topics: Animals; Aspirin; Blood Platelets; Blood Vessels; Dextrans; Diltiazem; Dipyridamole; Epoprostenol; Humans; Imidazoles; Ketanserin; Piperidines; Pyrazoles; Pyrazolones; Sulfinpyrazone; Sulfonamides; Thiophenes; Ticlopidine | 1986 |
Current concepts in the pathogenesis and interval treatment of migraine.
Topics: Adrenergic beta-Antagonists; Bradykinin; Clonidine; Cycloheptanes; Cyproheptadine; Ergotamine; Histamine; Humans; Methysergide; Migraine Disorders; Norepinephrine; Piperidines; Prostaglandins; Serotonin; Serotonin Antagonists; Thiophenes; Tyramine | 1972 |
Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches.
Topics: Animals; Blood Pressure; Clinical Trials as Topic; Cycloheptanes; Cyproheptadine; Dogs; Ergolines; Guinea Pigs; Haplorhini; Headache; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Lethal Dose 50; Methysergide; Mice; Migraine Disorders; Phenothiazines; Piperidines; Rabbits; Rats; Serotonin Antagonists; Thiophenes; Vascular Headaches | 1972 |
Dissociative anesthetics in the cat and dog.
Topics: Anesthesia, Inhalation; Anesthetics; Anesthetics, Dissociative; Animals; Cats; Cyclohexanes; Dioxoles; Dogs; Ethylamines; Injections, Intramuscular; Injections, Intravenous; Intubation, Intratracheal; Ketamine; Piperidines; Reflex; Thiophenes | 1972 |
Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Half-Life; Humans; Mammary Neoplasms, Experimental; Models, Biological; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Thiophenes | 1983 |
Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.
Topics: Aneuploidy; Angiogenesis Inhibitors; Anticarcinogenic Agents; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Carcinoma in Situ; Clinical Trials, Phase II as Topic; Cyclooxygenase Inhibitors; Disease Progression; Eflornithine; Endpoint Determination; Enzyme Inhibitors; Estrogens; Female; Fenretinide; Gonadotropin-Releasing Hormone; Humans; Hyperplasia; Isoflavones; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phenotype; Piperidines; Polyamines; Precancerous Conditions; Protein-Tyrosine Kinases; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Uterine Neoplasms | 2001 |
Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Endometrial Neoplasms; Female; Genes, Tumor Suppressor; Humans; Neoplasm Staging; Phosphoric Monoester Hydrolases; Piperidines; Progestins; PTEN Phosphohydrolase; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Survival Rate; Thiophenes; Tumor Suppressor Proteins | 2002 |
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cinnamates; Drug Design; Forecasting; Humans; Molecular Biology; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Toremifene; Treatment Outcome | 2002 |
Novel therapeutic options for osteoporosis.
Topics: Animals; Controlled Clinical Trials as Topic; Diphosphonates; Disease Models, Animal; Evidence-Based Medicine; Fractures, Spontaneous; Glycoproteins; Humans; Ibandronic Acid; Imidazoles; Norpregnenes; Osteoporosis; Osteoprotegerin; Piperidines; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Selective Estrogen Receptor Modulators; Thiophenes; Zoledronic Acid | 2002 |
A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Endometrial Neoplasms; Estradiol; Female; Fulvestrant; Humans; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2002 |
Selective estrogen receptor modulators: tissue actions and potential for CNS protection.
Topics: Animals; Breast Neoplasms; Cardiovascular System; Central Nervous System; Cognition; Estrogen Antagonists; Estrogen Receptor Modulators; Female; Hormone Replacement Therapy; Humans; Hypothalamo-Hypophyseal System; Male; Neuroprotective Agents; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Receptors, Neurotransmitter; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 2002 |
Will endothelin receptor antagonists have a role in heart failure?
Topics: Animals; Bosentan; Cardiovascular Agents; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Isoxazoles; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Thiophenes; Treatment Outcome | 2003 |
Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cetuximab; Clinical Trials as Topic; Colorectal Neoplasms; Cyclooxygenase 2; Deoxycytidine; Drug Administration Schedule; Enzyme Inhibitors; Flavonoids; Fluorouracil; Humans; Immunologic Factors; Irinotecan; Isoenzymes; Leucovorin; Membrane Proteins; Organoplatinum Compounds; Oxaliplatin; Piperidines; Prostaglandin-Endoperoxide Synthases; Quinazolines; Thiophenes; Treatment Outcome | 2003 |
Arzoxifene as therapy for endometrial cancer.
Topics: Antineoplastic Agents, Hormonal; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Endometrial Neoplasms; Female; Humans; Multicenter Studies as Topic; Piperidines; Selective Estrogen Receptor Modulators; Thiophenes | 2003 |
Arzoxifene Eli Lilly.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Drugs, Investigational; Humans; Neoplasms; Piperidines; Technology, Pharmaceutical; Thiophenes | 2003 |
ANTITUSSIVE DRUGS.
Topics: Antipsychotic Agents; Antitussive Agents; Chemistry, Pharmaceutical; Codeine; Cough; Dextromoramide; Drug Therapy; Humans; Meperidine; Methadone; Morphine; Pharmacology; Phenothiazines; Phenylacetates; Piperazines; Piperidines; Research; Thiophenes | 1963 |
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes | 2003 |
Arzoxifene: a promising new selective estrogen receptor modulator for clinical chemoprevention of breast cancer.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Female; Humans; Molecular Structure; Neoplasm Staging; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2004 |
Breast cancer chemoprevention: a review of selective estrogen receptor modulators.
Topics: Breast Neoplasms; Female; Humans; Piperidines; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2005 |
Arzoxifene: the development and clinical outcome of an ideal SERM.
Topics: Animals; Breast Neoplasms; Endometrial Neoplasms; Female; Humans; Piperidines; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Thiophenes; Treatment Outcome | 2006 |
[Status of novel bone-targeting SERMs in development].
Topics: Animals; Bone and Bones; Bone Density; Clinical Trials as Topic; Drug Design; Humans; Indoles; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Rats; Receptors, Estrogen; Research; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes | 2007 |
Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bone Density Conservation Agents; Denosumab; Drug Therapy, Combination; Female; Humans; Indoles; Middle Aged; Osteoporosis, Postmenopausal; Parathyroid Hormone; Piperidines; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; RANK Ligand; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Vitamin D; Women's Health | 2009 |
New selective estrogen receptor modulators (SERMs) in development.
Topics: Bone Density Conservation Agents; Breast Neoplasms; Female; Humans; Indoles; Osteoporosis; Piperidines; Pyrrolidines; Risk Factors; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes | 2010 |
Preventive therapy for breast cancer: a consensus statement.
Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles | 2011 |
An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis.
Topics: Bone Density Conservation Agents; Breast; Endometrium; Female; Fractures, Bone; Humans; Indoles; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes | 2012 |
[Third generation selective estrogen receptor modulators: benefits beyond bone. II, endometrial action].
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation, Preclinical; Endometrial Neoplasms; Endometrium; Estradiol; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Hot Flashes; Humans; Indoles; Menopause; Multicenter Studies as Topic; Organ Specificity; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Rats; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Thromboembolism | 2013 |
Breast Cancer Chemoprevention: A Network Meta-Analysis of Randomized Controlled Trials.
Topics: Adult; Aged; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Middle Aged; Norpregnenes; Piperidines; Postmenopause; Primary Prevention; Pyrrolidines; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes | 2016 |
Dietary and pharmacological treatment of abdominal pain in IBS.
Topics: Abdominal Pain; Anti-Infective Agents; Antidepressive Agents; Butyrophenones; Dipeptides; GABA Agents; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Imidazoles; Irritable Bowel Syndrome; Mentha piperita; Parasympatholytics; Phenylalanine; Piperidines; Plant Oils; Probiotics; Quaternary Ammonium Compounds; Rifamycins; Rifaximin; Serotonin 5-HT3 Receptor Antagonists; Thiophenes; Visceral Pain | 2017 |
The quest for new drugs to prevent osteoporosis-related fractures.
Topics: Benzoates; Biphenyl Compounds; Bone Density Conservation Agents; Drug Discovery; Humans; Osteoporosis; Osteoporotic Fractures; Piperidines; Propanolamines; Pyrrolidines; Tetrahydronaphthalenes; Thiophenes | 2017 |
Anterior chamber fibrinoid syndrome after cataract extraction in a patient on ibrutinib for B-cell chronic lymphocytic leukemia: a case report and review of the literature.
Topics: Adenine; Administration, Topical; Aged; Anterior Chamber; Antihypertensive Agents; Antineoplastic Agents; Brimonidine Tartrate; Cataract Extraction; Humans; Intraocular Pressure; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Phacoemulsification; Piperidines; Prednisolone; Pyrazoles; Pyrimidines; Sulfonamides; Syndrome; Thiophenes; Timolol; Treatment Outcome; Visual Acuity | 2018 |
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia.
Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; 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Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
New antipsychotic drugs for the treatment of agitation and psychosis in Alzheimer's disease: focus on brexpiprazole and pimavanserin.
Topics: Alzheimer Disease; Antipsychotic Agents; Anxiety; Humans; Piperidines; Psychotic Disorders; Quinolones; Thiophenes; Urea | 2020 |
82 trial(s) available for thiophenes and piperidines
| Article | Year |
|---|---|
Comparative studies of parasympatholytic drugs on stomach (double blind test) and analysis of relation between gastric form and tonus.
Topics: Adhesiveness; Adult; Aged; Barium Sulfate; Butylscopolammonium Bromide; Clinical Trials as Topic; Gastrointestinal Motility; Humans; Injections, Intramuscular; Male; Middle Aged; Muscle Tonus; Parasympatholytics; Piperidines; Pyrrolidines; Radiography; Stochastic Processes; Stomach; Thiophenes | 1975 |
[Controlled clinical trials of an oral anti-allergic agent (author's transl)].
Topics: Administration, Oral; Clinical Trials as Topic; Drug Evaluation; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal; Thiophenes | 1977 |
The protective effect of ketotifen in bronchial asthma.
Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Dyspnea; Female; Forced Expiratory Flow Rates; Histamine H1 Antagonists; Humans; Male; Middle Aged; Mucus; Piperidines; Thiophenes; Vital Capacity | 1978 |
[Comparison between desinsitization with pollen and administration of a new inhibiting agent of releasing histamin, "ketotifene" (author's transl)].
Topics: Desensitization, Immunologic; Drug Evaluation; Histamine H1 Antagonists; Piperidines; Pollen; Rhinitis, Allergic, Seasonal; Thiophenes; Tissue Extracts | 1978 |
[Drug prevention of bronchial asthma: inhibition of histamine and exercise-induced asthma by a new anti-anaphylactic oral preparation (ketotifen) (author's transl)].
Topics: Adult; Asthma; Bronchial Spasm; Clemastine; Cromolyn Sodium; Histamine; Histamine H1 Antagonists; Humans; Physical Exertion; Piperidines; Spirometry; Thiophenes | 1978 |
[An experimental and clinical study of the effect of ketotifen in the treatment of extrinsic bronchial asthma (author's transl)].
Topics: Asthma; Clemastine; Clinical Trials as Topic; Cromolyn Sodium; Drug Evaluation; Histamine H1 Antagonists; Humans; Piperidines; Thiophenes | 1979 |
The protective effect of a new agent, ketotifen syrup, in the treatment of childhood asthma.
Topics: Asthma; Chemical Phenomena; Chemistry; Child; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Histamine H1 Antagonists; Humans; Male; Peak Expiratory Flow Rate; Piperidines; Placebos; Thiophenes | 1979 |
A controlled study on the preventive effect of ketotifen, an antiallergic agent, on methacholine-induced bronchoconstriction in asthmatics.
Topics: Adolescent; Adult; Anaphylaxis; Asthma; Bronchial Spasm; Dose-Response Relationship, Drug; Double-Blind Method; Histamine H1 Antagonists; Humans; Methacholine Compounds; Middle Aged; Piperidines; Spirometry; Thiophenes | 1979 |
[Pharmacological and clinical demonstration of a prophylactic antiasthmatic effect illustrated by ketotifen (author's transl)].
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Histamine H1 Antagonists; Humans; Mast Cells; Passive Cutaneous Anaphylaxis; Piperidines; Rats; Tachyphylaxis; Thiophenes | 1979 |
Comparison between ketotifen and DSCG in bronchial challenge.
Topics: Adult; Allergens; Asthma; Bronchi; Bronchial Spasm; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Piperidines; Thiophenes | 1978 |
Clinical investigation of agents with prophylactic anti-allergic effects in bronchial asthma.
Topics: Acetylcholine; Aerosols; Asthma; Clemastine; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Forced Expiratory Volume; Histamine; Humans; Hypersensitivity; Physical Exertion; Piperidines; Thiophenes; Vital Capacity | 1978 |
Comparisons among HC 20-211 (Ketotifen), clemastine, DSCG and beclomethasone dipropionate in nasal challenge.
Topics: Adolescent; Adult; Beclomethasone; Clemastine; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Female; Humans; Male; Peak Expiratory Flow Rate; Piperidines; Pollen; Pyrrolidines; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Thiophenes | 1978 |
[Protection from exertion-induced bronchial asthma with disodium cromoglycate (DSCG) (cromolyn, lomudal, intal) and with ketotifen (zaditen). Doubly crossed double-blind study ].
Topics: Adolescent; Adult; Asthma; Cromolyn Sodium; Double-Blind Method; Female; Humans; Male; Middle Aged; Physical Exertion; Piperidines; Placebos; Thiophenes | 1979 |
A placebo-controlled trial of ketotifen (HC 20-511, Sandoz) in allergen induced asthma and comparison with disodium cromoglycate.
Topics: Adolescent; Allergens; Animals; Asthma; Cats; Child; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Female; Humans; Male; Peak Expiratory Flow Rate; Piperidines; Placebos; Thiophenes; Time Factors | 1979 |
Protective effect of ketotifen and disodium cromoglycate against bronchoconstriction induced by aspirin, benzoic acid or tartrazine in intolerant asthmatics.
Topics: Adult; Aged; alpha 1-Antitrypsin; Aspirin; Asthma; Benzoates; Bronchial Spasm; Complement C1 Inactivator Proteins; Cromolyn Sodium; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Piperidines; Tartrazine; Thiophenes | 1979 |
[Ketotifen, a new prophylactic agent in asthma (author's transl)].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Asthma; Child; Female; Humans; Ketotifen; Male; Middle Aged; Piperidines; Placebos; Theophylline; Thiophenes | 1979 |
A new antihistamine hc20-511 compared with dimetinden (fenistil retard) in the treatment of chronic urticaria and other pruritic dermatoses.
Topics: Adolescent; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Dimethindene; Drug Therapy, Combination; Female; Fumarates; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Pruritus; Skin Diseases; Thiophenes; Urticaria; Vomiting | 1975 |
Anti-asthmatic properties of a new peroral drug (HC 20-5II).
Topics: Adolescent; Adult; Asthma; Clemastine; Clinical Trials as Topic; Cycloheptanes; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Piperidines; Placebos; Thiophenes; Vital Capacity | 1977 |
Ketotifen in childhood asthma: a double-blind placebo controlled trial.
Topics: Asthma; Child; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Piperidines; Placebos; Respiratory Function Tests; Thiophenes | 1979 |
The clinical effect of ketotifen in bronchial asthma.
Topics: Adult; Asthma; Carbon Dioxide; Clinical Trials as Topic; Dyspnea; Female; Humans; Lung; Male; Middle Aged; Oxygen; Piperidines; Respiratory Function Tests; Spirometry; Thiophenes; Time Factors | 1979 |
[BC 105 in migraine].
Topics: Clinical Trials as Topic; Cycloheptanes; Evaluation Studies as Topic; Histamine H1 Antagonists; Humans; Methysergide; Migraine Disorders; Piperidines; Placebos; Serotonin Antagonists; Thiophenes | 1972 |
Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches.
Topics: Animals; Blood Pressure; Clinical Trials as Topic; Cycloheptanes; Cyproheptadine; Dogs; Ergolines; Guinea Pigs; Haplorhini; Headache; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Lethal Dose 50; Methysergide; Mice; Migraine Disorders; Phenothiazines; Piperidines; Rabbits; Rats; Serotonin Antagonists; Thiophenes; Vascular Headaches | 1972 |
A comparison between BC 105 and methysergide in the prophylaxis of migraine.
Topics: Adolescent; Adult; Body Weight; Clinical Trials as Topic; Cycloheptanes; Feeding and Eating Disorders; Female; Headache; Humans; Male; Methysergide; Middle Aged; Migraine Disorders; Piperidines; Thiophenes; Time Factors | 1972 |
[BC 105, a new preparation for migraine].
Topics: Body Weight; Clinical Trials as Topic; Cycloheptanes; Ergotamine; Humans; Migraine Disorders; Piperidines; Thiophenes | 1972 |
The prophylactic treatment of migraine with an antiserotonin pizotifen.
Topics: Adolescent; Adult; Clinical Trials as Topic; Cycloheptanes; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Prochlorperazine; Serotonin Antagonists; Thiophenes | 1973 |
BC-105 and deseril in migraine prophylaxis. (A double-blind study).
Topics: Adjustment Disorders; Benzocycloheptenes; Clinical Trials as Topic; Female; Humans; Male; Methysergide; Migraine Disorders; Piperidines; Placebos; Serotonin Antagonists; Thiophenes | 1973 |
[Zung's test for the quantitative assessment of depression and its confirmation during the testing of a new anti-migraine agent Sandomigran].
Topics: Antidepressive Agents; Benzocycloheptenes; Clinical Trials as Topic; Depression; Humans; Migraine Disorders; Piperidines; Psychiatric Status Rating Scales; Thiophenes | 1973 |
[BC-105 preparation in treatment of migraine].
Topics: Adult; Benzocycloheptenes; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Middle Aged; Migraine Disorders; Piperidines; Placebos; Serotonin Antagonists; Thiophenes | 1973 |
[Zung's test for the quantitative assessment of depression and its confirmation through the testing of a new anti-migraine drug Sandomigran].
Topics: Antidepressive Agents; Benzocycloheptenes; Clinical Trials as Topic; Depression; Drug Evaluation; Humans; Piperidines; Placebos; Psychiatric Status Rating Scales; Thiophenes | 1973 |
Effects of decompression on platelets and hemostasis in men and the influence of antiplatelet drugs (RA233 and VK744).
Topics: Adenosine Diphosphate; Adult; Aspartate Aminotransferases; Atmosphere Exposure Chambers; Atmospheric Pressure; Blood Cell Count; Blood Platelets; Cholinesterases; Clinical Trials as Topic; Creatine Kinase; Decompression Sickness; Epinephrine; Ethanolamines; Hematopoiesis; Hemostasis; Humans; L-Lactate Dehydrogenase; Male; Morpholines; Piperidines; Platelet Adhesiveness; Pyrimidines; Thiophenes; Thrombin; Thrombocytopenia; Time Factors | 1974 |
[Effect of a new orexigenic agent in pediatrics. Influence on appetite and growth].
Topics: Appetite; Benzocycloheptenes; Body Weight; Clinical Trials as Topic; Drug Evaluation; Feeding and Eating Disorders; Growth; Humans; Piperidines; Thiophenes | 1974 |
[Antidepressive effect of sandomigran].
Topics: Adult; Antidepressive Agents; Benzocycloheptenes; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Placebos; Psychological Tests; Thiophenes | 1974 |
Clinical physiological study of the action of BC 105 (Sandoz, Basle) in the interval therapy of migraine.
Topics: Acoustic Stimulation; Adult; Benzocycloheptenes; Cerebrovascular Circulation; Clinical Trials as Topic; Electroencephalography; Female; Fingers; Humans; Male; Middle Aged; Migraine Disorders; Photic Stimulation; Piperidines; Placebos; Plethysmography; Problem Solving; Thiophenes; Vasomotor System | 1974 |
[BC-105 in the prevention of migraine].
Topics: Adult; Benzocycloheptenes; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Serotonin Antagonists; Thiophenes | 1973 |
Clinical study of orexigenic action of a new antiserotonin agent, BC-105, in patients with pulmonary tuberculosis.
Topics: Adult; Aged; Appetite; Body Weight; Clinical Trials as Topic; Cycloheptanes; Female; Humans; Male; Middle Aged; Piperidines; Serotonin Antagonists; Stimulation, Chemical; Thiophenes; Tuberculosis, Pulmonary | 1972 |
[A new drug in the treatment of migraine (therapeutic trial)].
Topics: Adolescent; Adult; Body Weight; Clinical Trials as Topic; Cycloheptanes; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Sleep; Thiophenes | 1970 |
The treatment of migraine with BC 105 (pizotifen): a double blind trial.
Topics: Adolescent; Adult; Aged; Benzocycloheptenes; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Fatigue; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Placebos; Thiophenes; Wakefulness | 1971 |
[Double-blind studies on the appetite stimulating effect of a serotonin antagonist in the anorexic infant].
Topics: Adolescent; Appetite; Benzocycloheptenes; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Feeding and Eating Disorders; Humans; Infant; Piperidines; Serotonin Antagonists; Thiophenes | 1971 |
BC 105 in the prophylaxis of migraine.
Topics: Adult; Benzocycloheptenes; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Serotonin Antagonists; Thiophenes | 1971 |
[Effect of BC 105 on the depressed mood in migraine].
Topics: Adult; Aged; Antidepressive Agents; Benzocycloheptenes; Depression; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Thiophenes | 1972 |
[Differential diagnosis of headache and experiences with a new preparation in the treatment of migraine].
Topics: Benzocycloheptenes; Diagnosis, Differential; Headache; Humans; Migraine Disorders; Piperidines; Placebos; Thiophenes; Time Factors | 1970 |
Ketotifen in adult asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Albuterol; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Ketotifen; Male; Middle Aged; Piperidines; Sleep Stages; Thiophenes | 1980 |
[Long-term therapy of bronchial asthma with ketotifen. European experiences].
Topics: Administration, Oral; Adult; Asthma; Child; Cromolyn Sodium; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Histamine H1 Antagonists; Humans; Ketotifen; Piperidines; Thiophenes | 1980 |
[Treatment of seasonal asthmatic symptoms. A multicentre trial to compare the effects of ketotifen and disodium cromoglycate (author's transl)].
Topics: Adrenergic beta-Agonists; Asthma; Beclomethasone; Bronchitis; Clinical Trials as Topic; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Ketotifen; Piperidines; Random Allocation; Seasons; Spirometry; Theophylline; Thiophenes | 1980 |
The protective effect of ketotifen in bronchial asthma.
Topics: Asthma; Clinical Trials as Topic; Cromolyn Sodium; Female; Histamine H1 Antagonists; Humans; Ketotifen; Male; Piperidines; Thiophenes | 1980 |
A comparison of the efficacy of ketotifen (HC 20-511) with sodium cromoglycate (SCG) in skin test positive asthma.
Topics: Adolescent; Adult; Aged; Asthma; Cromolyn Sodium; Double-Blind Method; Drug Evaluation; Histamine H1 Antagonists; Humans; Ketotifen; Middle Aged; Piperidines; Skin Tests; Thiophenes | 1980 |
A comparison between the efficacy of ketotifen and clemastine in children.
Topics: Asthma; Child; Child, Preschool; Clemastine; Dyspnea; Female; Histamine H1 Antagonists; Humans; Infant; Ketotifen; Male; Piperidines; Pyrrolidines; Thiophenes | 1980 |
[Therapeutic effect of Zaditen (Sandoz) in atopic bronchial asthma].
Topics: Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Follow-Up Studies; Histamine H1 Antagonists; Humans; Ketotifen; Male; Middle Aged; Piperidines; Placebos; Thiophenes | 1980 |
[Experience in using a zaditen preparation in the therapy of bronchial asthma].
Topics: Adolescent; Adult; Aged; Asthma; Bronchitis; Capsules; Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; Humans; Ketotifen; Middle Aged; Piperidines; Placebos; Tablets; Thiophenes; Time Factors | 1981 |
Long-term study of the protective effect of ketotifen in children with allergic bronchial asthma. The value of a provocation test in assessment of treatment.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Cromolyn Sodium; Follow-Up Studies; Histamine H1 Antagonists; Humans; Ketotifen; Piperidines; Prognosis; Respiratory Function Tests; Thiophenes | 1981 |
A comparative study of the prophylactic effect of ketotifen and sodium cromoglycate in children with pollen-induced asthma.
Topics: Asthma; Child; Cromolyn Sodium; Double-Blind Method; Humans; Ketotifen; Piperidines; Pollen; Thiophenes | 1980 |
Clinical evaluation of a new orally active anti-anaphylactic compound: ketotifen (HC 20-511) in Japanese adult asthmatics.
Topics: Adult; Anaphylaxis; Asthma; Basophils; Cromolyn Sodium; Double-Blind Method; Humans; Hypersensitivity, Immediate; Japan; Ketotifen; Mast Cells; Piperidines; Placebos; Thiophenes | 1980 |
Ketotifen in bronchial asthma.
Topics: Adult; Aged; Asthma; Clinical Trials as Topic; Cromolyn Sodium; Humans; Ketotifen; Middle Aged; Piperidines; Prednisolone; Thiophenes | 1980 |
Double-blind study comparing ketotifen and DSCG in adolsecent asthmatics.
Topics: Adolescent; Asthma; Cromolyn Sodium; Double-Blind Method; Humans; Ketotifen; Piperidines; Thiophenes | 1980 |
Comparison of ketotifen, disodium cromoglycate and placebo in the treatment of adult patients with extrinsic asthma.
Topics: Adult; Asthma; Clinical Trials as Topic; Cromolyn Sodium; Humans; Ketotifen; Peak Expiratory Flow Rate; Piperidines; Placebos; Thiophenes | 1980 |
Ketotifen versus sodium cromoglycate in the therapy of allergic (extrinsic) bronchial asthma.
Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Cromolyn Sodium; Humans; Ketotifen; Middle Aged; Piperidines; Thiophenes | 1980 |
Comparison of the clinical effect of ketotifen and DSCG in pollen-induced childhood asthma.
Topics: Adolescent; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Cromolyn Sodium; Desensitization, Immunologic; Double-Blind Method; Drug Tolerance; Eosinophils; Female; Forced Expiratory Flow Rates; Humans; Immunoglobulin E; Ketotifen; Leukocyte Count; Male; Piperidines; Placebos; Pollen; Tablets; Thiophenes; Trees | 1980 |
[Protective effect of ketotifen and disodium cromoglycate in bronchial challenge tests with allergens (author's transl)].
Topics: Adolescent; Asthma; Child; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Dust; Female; Humans; Ketotifen; Male; Mites; Piperidines; Pollen; Thiophenes | 1980 |
A controlled trial of ketotifen in exercise-induced asthma.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Female; Humans; Ketotifen; Male; Middle Aged; Peak Expiratory Flow Rate; Piperidines; Thiophenes | 1980 |
Ketotifen and asthma.
Topics: Adult; Animals; Asthma; Child; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Humans; Ketotifen; Piperidines; Thiophenes | 1981 |
Comparison of ketotifen, disodium cromoglycate and placebo in the treatment of adult patients with mild extrinsic asthma.
Topics: Adult; Albuterol; Asthma; Circadian Rhythm; Cromolyn Sodium; Female; Humans; Ketotifen; Male; Middle Aged; Peak Expiratory Flow Rate; Piperidines; Placebos; Thiophenes; Time Factors | 1981 |
[Prophylactic treatment of exercise-induced asthma].
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Child; Child, Preschool; Cromolyn Sodium; Humans; Ketotifen; Piperidines; Thiophenes | 1981 |
Ketotifen for asthma.
Topics: Administration, Oral; Asthma; Child; Clinical Trials as Topic; Humans; Piperidines; Thiophenes | 1980 |
Ketotifen in adult asthma.
Topics: Aminophylline; Asthma; Clinical Trials as Topic; Humans; Ketotifen; Lung Volume Measurements; Piperidines; Thiophenes | 1980 |
Ketotifen in the prophylaxis of childhood asthma.
Topics: Asthma; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infant; Ketotifen; Male; Piperidines; Thiophenes | 1981 |
[Methods employed in the post-marketing surveillance of an oral agent for asthma-prophylaxis (author's transl)].
Topics: Administration, Oral; Asthma; Clinical Trials as Topic; Humans; Ketotifen; Piperidines; Thiophenes | 1981 |
[Ketotifene in asthma in childhood].
Topics: Asthma; Child; Humans; Ketotifen; Piperidines; Thiophenes | 1980 |
[Short-term effect of ketotiphen on physicochemical sputim characteristics in patients with chronic reversible respiratory diseases].
Topics: Adult; Aged; Drug Administration Schedule; Female; Fucose; Glycoproteins; Humans; Immunoglobulin A; Ketotifen; Male; Middle Aged; Piperidines; Respiratory Tract Diseases; Sialic Acids; Sputum; Thiophenes; Viscosity | 1980 |
Phase I study of a third-generation selective estrogen receptor modulator, LY353381.HCL, in metastatic breast cancer.
Topics: Actuarial Analysis; Adult; Aged; Breast Neoplasms; Dose-Response Relationship, Drug; Endometrium; Estrogen Antagonists; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Piperidines; Thiophenes | 2001 |
Phase II, randomized, double-blind study of two dose levels of arzoxifene in patients with locally advanced or metastatic breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Neoplasm; Endometrium; Estrogen Receptor Modulators; Female; Humans; Middle Aged; Patient Selection; Piperidines; Receptors, Estrogen; Survival Analysis; Tamoxifen; Thiophenes; Treatment Outcome | 2003 |
A phase II trial of arzoxifene, a selective estrogen response modulator, in patients with recurrent or advanced endometrial cancer.
Topics: Adult; Aged; Aged, 80 and over; Disease-Free Survival; Endometrial Neoplasms; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Piperidines; Selective Estrogen Receptor Modulators; Thiophenes | 2003 |
Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Endometrium; Female; Humans; Middle Aged; Piperidines; Selective Estrogen Receptor Modulators; Thiophenes | 2003 |
Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulator.
Topics: Anticarcinogenic Agents; Biopsy; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrone; Female; Hormones; Humans; Middle Aged; Patient Selection; Piperidines; Postmenopause; Reoperation; Selective Estrogen Receptor Modulators; Thiophenes | 2004 |
Phase III double-blind trial of arzoxifene compared with tamoxifen for locally advanced or metastatic breast cancer.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Double-Blind Method; Female; Humans; Piperidines; Postmenopause; Receptors, Steroid; Survival Analysis; Tamoxifen; Thiophenes; Time Factors; Treatment Failure | 2007 |
Effects of arzoxifene on bone mineral density and endometrium in postmenopausal women with normal or low bone mass.
Topics: Aged; Algorithms; Antineoplastic Agents; Bone and Bones; Bone Density; Breast Neoplasms; Carcinoma; Endometrium; Female; Humans; Middle Aged; Organ Size; Piperidines; Placebos; Postmenopause; Thiophenes | 2009 |
Effects of arzoxifene on bone, lipid markers, and safety parameters in postmenopausal women with low bone mass.
Topics: Aged; Biomarkers; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Female; Humans; Lipids; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Vasomotor System | 2010 |
Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women.
Topics: Aged; Aged, 80 and over; Bone Resorption; Breast Neoplasms; Diphosphonates; Female; Fractures, Bone; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Placebos; Postmenopause; Selective Estrogen Receptor Modulators; Thiophenes | 2011 |
Arzoxifene versus raloxifene: effect on bone and safety parameters in postmenopausal women with osteoporosis.
Topics: Absorptiometry, Photon; Aged; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Double-Blind Method; Female; Femur Neck; Hip Joint; Hot Flashes; Humans; Lumbar Vertebrae; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Thiophenes; Treatment Outcome | 2012 |
Gynecologic effects of arzoxifene in postmenopausal women with osteoporosis or low bone mass.
Topics: Aged; Aged, 80 and over; Endometrial Neoplasms; Endometrium; Female; Genital Diseases, Female; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Placebos; Polyps; Postmenopause; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Uterine Hemorrhage; Vaginitis; Vulvitis | 2012 |
Breast cancer incidence in postmenopausal women with osteoporosis or low bone mass using arzoxifene.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Double-Blind Method; Female; Fractures, Bone; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Postmenopause; Risk Factors; Thiophenes | 2012 |
Ipragliflozin as an Initial Therapy in Drug Naïve Subjects with Type 2 Diabetes.
Topics: Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Prospective Studies; Thiophenes; Uracil | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; 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Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; 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STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
223 other study(ies) available for thiophenes and piperidines
| Article | Year |
|---|---|
[From the Adverse Drug Reaction Committe. Sandosten-Calcium].
Topics: Agranulocytosis; Histamine H1 Antagonists; Humans; Piperidines; Thiophenes | 1976 |
Intestinal absorption of a new anticholinergic agent, timepidium bromide. I. Various factors influencing absorption.
Topics: Animals; Bile; Carboxylic Acids; Fasting; Hydrogen-Ion Concentration; Intestinal Absorption; Male; Osmolar Concentration; Parasympatholytics; Piperidines; Rats; Thiophenes | 1978 |
[Specific and aspecific activity of an antihistaminic of the H1 type: HC 20-511 or ketothiphen (benzo-cyclohepta-thiophenone derivative)].
Topics: Albuterol; Anaphylaxis; Animals; Anura; Bronchial Spasm; Cardiovascular System; Chlorpheniramine; Dogs; Drug Evaluation, Preclinical; Female; Gastric Juice; Guinea Pigs; Histamine H1 Antagonists; Inflammation; Male; Mice; Muscle, Smooth; Piperidines; Pizotyline; Rats; Respiration; Stomach Ulcer; Thiophenes | 1977 |
The protective effect of a new oral anti-asthma agent (ketotifen, HC 20--511) against experimentally induced bronchospasm (5 different models).
Topics: Acetylcholine; Aerosols; Antigens; Aspirin; Benzoates; Bronchial Spasm; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Physical Exertion; Piperidines; Placebos; Tartrazine; Thiophenes | 1978 |
[Sandosten poisoning in childhood].
Topics: Child, Preschool; Diazepam; Drug Therapy, Combination; Female; Furosemide; Gastric Lavage; Histamine H1 Antagonists; Humans; Piperidines; Poisoning; Thiophenes | 1979 |
The pharmacological properties of a new, orally active antianaphylactic compound: ketotifen, a benzocycloheptathiophene.
Topics: Anaphylaxis; Anesthetics, Local; Animals; Cats; Central Nervous System Agents; Dogs; Female; Guinea Pigs; Haplorhini; Hemodynamics; Histamine Antagonists; Histamine H1 Antagonists; In Vitro Techniques; Kidney; Macaca mulatta; Male; Mice; Parasympatholytics; Phosphodiesterase Inhibitors; Piperidines; Rats; Serotonin Antagonists; Thiophenes | 1978 |
Bronchial reactivity in asthma to inhaled histamine during treatment with ketotifen.
Topics: Adult; Asthma; Bronchi; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Respiratory Function Tests; Thiophenes; Time Factors | 1979 |
Effects of ketotifen and clemastine on passive transfer of reaginic reaction.
Topics: Clemastine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Immunization, Passive; Immunoglobulin E; Mast Cells; Piperidines; Pyrrolidines; Reagins; Thiophenes; Time Factors | 1979 |
Preventive effect of ketotifen, a new antiallergic agent, on histamine-induced bronchoconstriction in asthmatics.
Topics: Adolescent; Adult; Asthma; Constriction, Pathologic; Female; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Piperidines; Thiophenes; Vital Capacity | 1979 |
Ketotifen: a histamine release inhibitor.
Topics: Anaphylaxis; Animals; Clemastine; Cromolyn Sodium; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Histamine Release; Ovalbumin; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Piperidines; Rats; Thiophenes | 1977 |
Pharmacological models for characterizing new anti-asthmatics.
Topics: Animals; Asthma; Histamine H1 Antagonists; Histamine Release; Humans; In Vitro Techniques; Leukocytes; Piperidines; Rats; SRS-A; Thiophenes | 1978 |
Inhibition of chemical mediator release from human leukocytes by a new antiasthma drug, HC 20-511 (ketotifen).
Topics: Antigens; Asthma; Calcimycin; Cromolyn Sodium; Histamine Release; Humans; Immunoglobulin E; Leukocytes; Neutrophils; Piperidines; SRS-A; Thiophenes | 1979 |
[Ketotifen, a selective histamine liberator].
Topics: Animals; Histamine Release; Kinetics; Male; Mast Cells; Piperidines; Rats; Temperature; Thiophenes | 1979 |
Changing the therapy of stable asthmatic patients.
Topics: Asthma; Cromolyn Sodium; Drug Administration Schedule; Drug Evaluation; Humans; Piperidines; Thiophenes | 1979 |
[Agranulocytosis probably induced by thenalidine (Sandosten comp.)].
Topics: Aged; Agranulocytosis; Aniline Compounds; Bone Marrow; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Thiophenes | 1975 |
Short-term effect of ketotifen on sputum physicochemical characteristics in chronic reversible airway disease.
Topics: Adult; Aged; Asthma; Double-Blind Method; Female; Humans; Ketotifen; Male; Middle Aged; Piperidines; Random Allocation; Sputum; Thiophenes | 1979 |
[Experience with the treatment of childhood allergies using the new preparation ketotifen (Zaditen)].
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Male; Piperidines; Respiratory Hypersensitivity; Rhinitis, Allergic, Seasonal; Thiophenes | 1979 |
Metabolic fate of timepidium bromide (SA-504)--Unstable metabolities in the rats.
Topics: Animals; Bile; Carbon Radioisotopes; Chemical Phenomena; Chemistry; Pigments, Biological; Piperidines; Rats; Structure-Activity Relationship; Thiophenes; Tritium | 1977 |
Intestinal absorption of a new anticholinergic agent, timepidium bromide. II. Enhancement of absorption.
Topics: Animals; Carboxylic Acids; Citrates; Gastric Emptying; Intestinal Absorption; Male; Osmolar Concentration; Parasympatholytics; Piperidines; Rats; Thiophenes | 1978 |
[Pharmacological actions of timepidium bromide on the motility of visceral smooth muscles and the secretion of digestive juice in experimental animals (author's transl)].
Topics: Animals; Atropine; Bethanechol Compounds; Bile; Blood Pressure; Butylscopolammonium Bromide; Cats; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Female; Gallbladder; Gastric Juice; Gastrointestinal Motility; Male; Mice; Muscle Contraction; Muscle, Smooth; Mydriatics; Pancreatic Juice; Piperidines; Rats; Salivation; Thiophenes; Uterine Contraction | 1978 |
Relationship between pharmacological activity and blood level of a new anticholinergic agent, timepidium bromide (SA-504), in cats.
Topics: Animals; Bile; Cats; Female; Hemodynamics; Intestinal Absorption; Male; Motor Activity; Parasympatholytics; Piperidines; Pupil; Thiophenes; Time Factors | 1976 |
Changes of epidermal cell morphology and keratin expression induced by inhibitors of protein kinase C.
Topics: Alkaloids; Calmodulin; Cell Line; Humans; Indoles; Keratinocytes; Keratins; Piperidines; Protein Kinase C; Staurosporine; Thiophenes | 1992 |
The cardiovascular effects of quipazine are mediated by peripheral 5-HT2 and 5-HT3 receptors in anaesthetized rats.
Topics: Amidines; Anesthesia; Animals; Blood Pressure; Carotid Body; Denervation; Heart Rate; Hemodynamics; Hexamethonium Compounds; In Vitro Techniques; Indoles; Lung; Male; Myocardium; Piperidines; Prazosin; Pressoreceptors; Propanolamines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Renin-Angiotensin System; Ritanserin; Sympathetic Nervous System; Thiophenes; Tropisetron; Vagotomy | 1990 |
Structure-activity relationship of antiestrogens. Effect of the side chain and its position on the activity of 2,3-diaryl-2H-1-benzopyrans.
Topics: Animals; Benzopyrans; Binding, Competitive; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Mice; Microsomes, Liver; Molecular Structure; Organ Size; Piperidines; Pyrrolidines; Rats; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 1990 |
The stimulation of uterine complement component C3 gene expression by antiestrogens.
Topics: Animals; Complement C3; Drug Interactions; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation; Kinetics; Nucleic Acid Hybridization; Piperidines; Progesterone; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; RNA, Messenger; Tamoxifen; Thiophenes; Uterus | 1990 |
Biochemical pharmacological profile of migraine prophylactics of pizotifen type.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Male; Migraine Disorders; Piperidines; Pizotyline; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Thiophenes | 1989 |
Parkinson's tremor, relief by an antiaminic drug (BC 105). Discussion on the biochemical pathogenesis of Parkinsonian tremor.
Topics: Adult; Aged; Benzocycloheptenes; Dihydroxyphenylalanine; Ergolines; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Parkinson Disease; Piperidines; Promethazine; Thiophenes; Tremor; Trihexyphenidyl | 1972 |
Protective effect of cyproheptadine and BC 105 against the lethal effects of exudates from rat burnt skin.
Topics: Animals; Benzocycloheptenes; Burns; Cyproheptadine; Exudates and Transudates; Histamine H1 Antagonists; Piperidines; Rats; Skin; Thiophenes; Tissue Extracts | 1973 |
BC-105--a new prophylactic agent for migraine--four years' experience in seventy-five patients.
Topics: Adult; Benzocycloheptenes; Female; Histamine H1 Antagonists; Humans; Male; Migraine Disorders; Piperidines; Serotonin Antagonists; Thiophenes | 1973 |
Prevention of serotonin abortion by serotonin antagonists in rats.
Topics: Abortion, Induced; Animals; Atropine; Benzocycloheptenes; Dimethylamines; Ergolines; Female; Gestational Age; Hydroxyzine; Pargyline; Phenothiazines; Piperidines; Pregnancy; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Serotonin Antagonists; Sulfonamides; Thiophenes; Tripelennamine; Tryptamines | 1973 |
Dye salt formation as a general method for colorimetric determination of antihistaminics. Part 2: Spectrophotometric determination of thenalidine maleate and thiazinamium methylsulphate in pure and dosage forms.
Topics: Aniline Compounds; Colorimetry; Coloring Agents; Dosage Forms; Histamine H1 Antagonists; Maleates; Piperidines; Promethazine; Salts; Spectrophotometry; Thiophenes | 1974 |
The responses of the human temporal and rabbit ear artery to 5-hydroxytryptamine and some of its antagonists.
Topics: Animals; Arteries; Benzocycloheptenes; Blood Pressure; Constriction; Cyproheptadine; Dose-Response Relationship, Drug; Drug Synergism; Ear, External; Ergot Alkaloids; Histamine; Histamine H1 Antagonists; Humans; Methysergide; Norepinephrine; Perfusion; Piperidines; Rabbits; Serotonin; Serotonin Antagonists; Stimulation, Chemical; Temporal Arteries; Thiophenes | 1974 |
The antiviral activity of some related benzo(b) thiophene derivatives. II. Anti-influenza activity.
Topics: Amantadine; Animals; Antigens, Viral; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Fluorescent Antibody Technique; Haplorhini; HeLa Cells; Hemadsorption; Humans; Kidney; Orthomyxoviridae; Phenylalanine; Piperidines; Pyrrolidines; Thiophenes; Time Factors; Virus Replication | 1974 |
The effect of pyrimidine compounds on the potentiation of adenosine inhibition of aggregation, on adenosine phosphorylation and phosphodiesterase activity of blood platelets.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Carbon Isotopes; Cyclic AMP; Dipyridamole; Ethanolamines; Ethylamines; Humans; In Vitro Techniques; Morpholines; Phosphoric Diester Hydrolases; Piperidines; Platelet Adhesiveness; Pyrimidines; Thiophenes | 1973 |
[The antagonism exercised by Sandomigran (BC 105) on some properties of bradykinin].
Topics: Adrenal Medulla; Adrenalectomy; Animals; Atropine; Benzocycloheptenes; Blood Pressure; Bradykinin; Dose-Response Relationship, Drug; Guanethidine; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Norepinephrine; Peptidyl-Dipeptidase A; Piperidines; Rats; Receptors, Drug; Serotonin; Stimulation, Chemical; Thiophenes; Tyramine | 1973 |
[Functioning malignant carcinoid (case report. Preliminary results of treatment with 3 new drugs)].
Topics: Biopsy; Carbamates; Carcinoid Tumor; Cycloheptanes; Female; Histamine H1 Antagonists; Humans; Liver Neoplasms; Middle Aged; Piperidines; Pyridinium Compounds; Serotonin Antagonists; Thiophenes | 1969 |
[The continuous measurement of platelet aggregation without the addition of aggregation inducers. II. Experimental results and testing of aggregation inducers].
Topics: Aspirin; Benzyl Compounds; Cycloheptanes; Dimethylamines; Ethanolamines; Fibrinogen; Humans; In Vitro Techniques; Morpholines; Photometry; Piperazines; Piperidines; Platelet Adhesiveness; Platelet Aggregation; Polysaccharides; Pyrimidines; Sulfuric Acids; Thiophenes | 1974 |
Uptake of 3H-cyproheptadine by rat myometrium in vitro.
Topics: Animals; Benzocycloheptenes; Binding, Competitive; Calcium; Chlorpromazine; Cyproheptadine; Estradiol; Female; In Vitro Techniques; Muscle, Smooth; Piperidines; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Serotonin; Thiophenes; Time Factors; Tritium; Uterus | 1974 |
Pharmacological properties of a new anticholinergic agent, 1, 1-dimethyl-5-methoxy-3-(dithien-2-ylmethylene) piperidinium bromide (SA-504).
Topics: Anesthetics, Local; Animals; Cardiovascular System; Cats; Depression, Chemical; Female; Ganglia, Autonomic; Gastric Juice; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Irritants; Male; Methemoglobin; Methyl Ethers; Mice; Muscle Contraction; Muscle, Smooth; Mydriatics; Parasympatholytics; Piperidines; Rats; Respiration; Salivation; Stomach Ulcer; Thiophenes | 1972 |
[Sandomigrin in migraine therapy].
Topics: Administration, Oral; Body Weight; Cycloheptanes; Follow-Up Studies; Humans; Migraine Disorders; Piperidines; Thiophenes; Time Factors | 1972 |
[Horton's headaches treated with sandomigran (BC-105)].
Topics: Administration, Oral; Adult; Benzocycloheptenes; Facial Neuralgia; Female; Histamine; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Sex Factors; Thiophenes | 1973 |
Long-term effect and tolerance during prophylactic treatment of migraine with a benzo-cycloheptathiophene derivative, pizotifen.
Topics: Adult; Aged; Benzocycloheptenes; Drug Tolerance; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Thiophenes | 1973 |
[Usefulness of Sandomigran in treatment of migraine syndromes].
Topics: Adolescent; Adult; Benzocycloheptenes; Drug Tolerance; Female; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Syndrome; Thiophenes | 1973 |
Metabolic fate of 1,1-dimethyl-5-methoxy-3-(dithien-2-ylmethylene)piperidinium bromide (SA-504). I. Biliary metabolites in rats.
Topics: Animals; Bile; Carbon Radioisotopes; Male; Methyl Ethers; Microsomes, Liver; Parasympatholytics; Piperidines; Rats; Thiophenes | 1973 |
[Sandomigrin (pizotiphenum NFN) in migraine prevention].
Topics: Benzocycloheptenes; Humans; Migraine Disorders; Piperidines; Thiophenes | 1973 |
Anti-nociceptive activity of some thiophthalanes with morphine-like properties.
Topics: Analgesia; Analgesics; Animals; Bridged-Ring Compounds; Depression, Chemical; Dextropropoxyphene; Dimethylamines; Electric Stimulation; Ketones; Male; Meperidine; Methadone; Mice; Morphine; Pain; Piperidines; Thiophenes | 1973 |
[An efficacy study of a new antispasmodica, SA-504 upon the myogram and intraluminal pressure of the human colon (author's transl)].
Topics: Adult; Colon; Colonic Diseases, Functional; Electrodes; Electromyography; Female; Gastrointestinal Motility; Humans; Injections, Intramuscular; Injections, Subcutaneous; Middle Aged; Neostigmine; Parasympatholytics; Piperidines; Pressure; Secretin; Thiophenes | 1973 |
Inhibition of cancer cell stickiness by the blocking of platelet aggregation.
Topics: Adhesiveness; Animals; Antineoplastic Agents; Blood Cell Count; Blood Platelets; Capillaries; Carcinoma 256, Walker; Dipyridamole; Embolism; Endothelium; Head; Head and Neck Neoplasms; Humans; Lung Neoplasms; Morpholines; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Cells, Circulating; Piperidines; Platelet Adhesiveness; Pulmonary Embolism; Pyrimidines; Rats; Sarcoma; Thiophenes; Transplantation, Homologous; Vasodilator Agents | 1974 |
[Therapeutic use of Sandomigran (BC-105)].
Topics: Appetite; Benzocycloheptenes; Body Weight; Female; Humans; Piperidines; Serotonin Antagonists; Spinal Osteophytosis; Thiophenes | 1974 |
Potential hypolipidemic agents. 8. 2-Chloro-5-piperidinosulphono-3-thiophenecarboxylic acids.
Topics: Animals; Body Weight; Carboxylic Acids; Cholesterol; Clofibrate; Depression, Chemical; Drug Evaluation, Preclinical; Hydrocarbons, Chlorinated; Lipid Mobilization; Male; Piperidines; Sulfones; Sulfonic Acids; Thiophenes; Triglycerides | 1974 |
Lack of effect of the appetite stimulant pizotifen (BC 105) on the absorption of isonicotinylhydrazine.
Topics: Adult; Benzocycloheptenes; Half-Life; Humans; Intestinal Absorption; Isoniazid; Male; Middle Aged; Piperidines; Regression Analysis; Thiophenes; Time Factors | 1974 |
[Sandomigran (BC-105) in treatment of migraine and Horton's headache].
Topics: Adult; Chemical Phenomena; Chemistry; Cycloheptanes; Evaluation Studies as Topic; Facial Neuralgia; Female; Histamine; Humans; Male; Middle Aged; Migraine Disorders; Piperidines; Serotonin; Serotonin Antagonists; Thiophenes; Vascular Headaches | 1972 |
[Clinical studies of anesthesia adjuvants. I. Effect of SA-504 on circulatory dynamics].
Topics: Adjuvants, Anesthesia; Adult; Aged; Anesthesia, Epidural; Anesthesia, General; Female; Halothane; Hemodynamics; Humans; Male; Methyl Ethers; Middle Aged; Parasympatholytics; Piperidines; Thiophenes | 1972 |
The effects of cyproheptadine, methysergide, BC 105 and reserpine on brain 5-hydroxytryptamine and brain growth.
Topics: Animals; Benzocycloheptenes; Body Weight; Brain; Brain Chemistry; Cyproheptadine; Methysergide; Organ Size; Piperidines; Rats; Reserpine; Serotonin; Thiophenes | 1972 |
Seminar on headache.
Topics: Benzocycloheptenes; Diagnosis, Differential; Ergotamine; Headache; Humans; Methysergide; Migraine Disorders; Pain; Piperidines; Thiophenes | 1971 |
[Long-term therapy of persistent migraine with BC-105].
Topics: Benzocycloheptenes; Humans; Migraine Disorders; Piperidines; Thiophenes | 1970 |
Thermographic, hormonal, and clinical studies in migraine.
Topics: Body Temperature; Cycloheptanes; Cyproheptadine; Ergolines; Female; Humans; Menstruation; Methysergide; Migraine Disorders; Phenothiazines; Piperidines; Progesterone; Reserpine; Serotonin Antagonists; Skin Temperature; Thermography; Thiophenes; Urea | 1970 |
3-Aminomethyl-5-hydroxybenzo[b]thiophenes.
Topics: Amines; Animals; Benzene Derivatives; Cattle; Central Nervous System; Electroencephalography; Male; Methods; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Piperidines; Rabbits; Thiophenes | 1968 |
[Ketotifen--a new anti-asthma drug].
Topics: Asthma; Bronchodilator Agents; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Ketotifen; Piperidines; Thiophenes | 1980 |
Inhibition by ketotifen of idiosyncratic reactions to aspirin.
Topics: Adult; Aspirin; Asthma; Bronchi; Bronchial Spasm; Drug Hypersensitivity; Female; Histamine H1 Antagonists; Humans; Ketotifen; Male; Middle Aged; Piperidines; Placebos; Thiophenes | 1980 |
[Ketotifen and platelet aggregation: in vitro studies].
Topics: Animals; Histamine H1 Antagonists; In Vitro Techniques; Ketotifen; Piperidines; Platelet Aggregation; Rabbits; Thiophenes | 1980 |
Ketotifen overdose: surveillance of the toxicity of a new drug.
Topics: Adolescent; Adult; Child; Drug Evaluation; Female; Histamine H1 Antagonists; Humans; Ketotifen; Male; Piperidines; Prognosis; Thiophenes | 1981 |
Dissociation between the anti-anaphylactic and the anti-histaminic actions of ketotifen.
Topics: Airway Resistance; Anaphylaxis; Animals; Antigens; Clemastine; Female; Histamine H1 Antagonists; Ketotifen; Piperidines; Pyrilamine; Rats; Skin Tests; Thiophenes | 1981 |
["Bronchitis"-therapy today].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Antitussive Agents; Bronchitis; Expectorants; Histamine H1 Antagonists; Humans; Ketotifen; Parasympatholytics; Physical Therapy Modalities; Piperidines; Thiophenes; Xanthines | 1981 |
Ketotifen in the treatment of diabetics with various allergic conditions.
Topics: Biguanides; Blood; Diabetes Complications; Diabetes Mellitus; Drug Interactions; Female; Glucose Tolerance Test; Histamine H1 Antagonists; Humans; Hypersensitivity; Ketotifen; Male; Middle Aged; Piperidines; Sulfonylurea Compounds; Thiophenes | 1981 |
Inhibition of allergen-mediated histamine release from human cells by ketotifen and oxatomide. Comparison with other H1 antihistamines.
Topics: Allergens; Cells, Cultured; Depression, Chemical; Dust; Histamine H1 Antagonists; Histamine Release; Humans; Ketotifen; Leukocytes; Lung; Piperazines; Piperidines; Pollen; Thiophenes | 1981 |
Clinical effects of HC 20-511 (ketotifen) in bronchial asthma and its inhibitory effect on antigen-induced morphological changes of basophils.
Topics: Adolescent; Adult; Allergens; Asthma; Basophils; Female; Humans; Immunoglobulin E; Ketotifen; Male; Middle Aged; Piperidines; Thiophenes | 1980 |
Non-steroidal antioestrogens--receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line; Estrogen Antagonists; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus | 1984 |
Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens.
Topics: Animals; Estradiol; Estrogen Antagonists; Female; Mammary Neoplasms, Experimental; Organ Size; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Tamoxifen; Thiophenes; Uterus | 1983 |
[Ketotifene: experimental and clinical data].
Topics: Administration, Oral; Animals; Asthma; Binding, Competitive; Cromolyn Sodium; Histamine Antagonists; Humans; Ketotifen; Piperidines; Rats; Receptors, Histamine H1; SRS-A; Thiophenes | 1980 |
[Ketotiphen (Zaditen) in the treatment of asthma].
Topics: Adolescent; Adult; Asthma; Cromolyn Sodium; Double-Blind Method; Female; Humans; Ketotifen; Male; Middle Aged; Piperidines; Thiophenes | 1980 |
Ketotifen, an anti-allergic drug. Pharmacological figures anc clinical experience.
Topics: Asthma; Cromolyn Sodium; Humans; Hypersensitivity; Ketotifen; Piperidines; Thiophenes | 1980 |
Use of anterior rhinometry in nasal provocation challenges with allergen and evaluation of the effects of ketotifen, clemastine and sodium cromoglycate on these responses.
Topics: Adolescent; Adult; Clemastine; Cromolyn Sodium; Female; Humans; Ketotifen; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Perennial; Thiophenes | 1980 |
Effect of ketotifen in some immunological animal models.
Topics: Animals; Anti-Inflammatory Agents; Cromolyn Sodium; Guinea Pigs; Immunosuppressive Agents; Ketotifen; Lymphocyte Activation; Lymphocytes; Mice; Models, Biological; Piperidines; Thiophenes | 1980 |
Comparison of actions of disodium cromoglycate and ketotifen on exercise-induced bronchoconstriction in childhood asthma.
Topics: Asthma; Asthma, Exercise-Induced; Child; Cromolyn Sodium; Humans; Ketotifen; Piperidines; Thiophenes | 1980 |
A steroid sparing effect of ketotifen in steroid-dependent asthmatics.
Topics: Adult; Aged; Anaphylaxis; Asthma; Cromolyn Sodium; Double-Blind Method; Female; Humans; Ketotifen; Male; Middle Aged; Peak Expiratory Flow Rate; Piperidines; Placebos; Prednisolone; Substance-Related Disorders; Thiophenes | 1980 |
Actions of disodium cromoglycate and ketotifen on exercise-induced bronchoconstriction.
Topics: Asthma; Asthma, Exercise-Induced; Cromolyn Sodium; Humans; Ketotifen; Piperidines; Thiophenes | 1981 |
Drugs for asthma: mast-cell stabilisers.
Topics: Asthma; Cromolyn Sodium; Humans; Ketotifen; Mast Cells; Piperidines; Thiophenes | 1981 |
Contemporary problems of epidemiology and treatment of respiratory allergies and bronchial asthma.
Topics: Adult; Asthma; Bacterial Vaccines; Cromolyn Sodium; Desensitization, Immunologic; Humans; Ketotifen; Piperidines; Respiratory Hypersensitivity; Thiophenes | 1980 |
[Direct action of timepidium bromide on the gastric mucosa and its inhibitory effect on pepsin secretion (author's transl)].
Topics: Animals; Depression, Chemical; Gastric Mucosa; Ligation; Male; Parasympatholytics; Pepsin A; Piperidines; Rats; Rats, Inbred Strains; Thiophenes | 1981 |
[Protective effect of ketotifen, investigations in allergic children with bronchial asthma (author's transl)].
Topics: Administration, Topical; Adolescent; Asthma; Bronchodilator Agents; Child; Child, Preschool; Cough; Dyspnea; Humans; Ketotifen; Piperidines; Steroids; Thiophenes | 1980 |
Ketotifen and terbutaline in urticaria.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Ketotifen; Male; Middle Aged; Piperidines; Terbutaline; Thiophenes; Urticaria | 1981 |
Carbon monoxide yield of cigarettes.
Topics: Carbon Monoxide; Humans; Ketotifen; Oxygen; Piperidines; Smoking; Tars; Thiophenes; Vascular Diseases | 1980 |
Ketotifen in adult asthma.
Topics: Adult; Asthma; Humans; Ketotifen; Piperidines; Sleep Stages; Thiophenes | 1980 |
Ketotifen in adult asthma.
Topics: Adult; Asthma; Humans; Ketotifen; Piperidines; Sleep Stages; Thiophenes | 1980 |
Oral prophylaxis of bronchial asthma in children.
Topics: Administration, Oral; Asthma; Blood Pressure; Child; Child, Preschool; Double-Blind Method; Humans; Infant; Ketotifen; Piperidines; Pulse; Steroids; Thiophenes | 1980 |
Inhibition of idiosyncratic reactions to aspirin by ketotifen.
Topics: Adult; Aspirin; Asthma; Bronchial Spasm; Drug Hypersensitivity; Humans; Ketotifen; Piperidines; Thiophenes | 1980 |
Effects of cyproheptadine, ketotifen and sodium nitroprusside on mechanical activity and calcium uptake in guinea pig taenia coli in vitro.
Topics: Animals; Calcium; Colon; Cyproheptadine; Ferricyanides; Guinea Pigs; Ketotifen; Muscle Contraction; Nitroprusside; Piperidines; Thiophenes | 1980 |
Ketotifen in adult asthma.
Topics: Dizziness; Humans; Ketotifen; Piperidines; Sleep Stages; Thiophenes | 1980 |
[Our experience with the preparation ketotiphen (author's transl)].
Topics: Adolescent; Adult; Asthma; Female; Humans; Ketotifen; Male; Middle Aged; Piperidines; Thiophenes | 1980 |
Effects of timepidium bromide, hyoscine-N-butylbromide and atropine on the isolated guinea pig gallbladder and sphincter of Oddi.
Topics: Acetylcholine; Ampulla of Vater; Animals; Atropine; Butylscopolammonium Bromide; Depression, Chemical; Electric Stimulation; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Norepinephrine; Parasympatholytics; Perfusion; Piperidines; Scopolamine Derivatives; Sphincter of Oddi; Thiophenes | 1980 |
Dopamine receptor agonist potencies for inhibition of cell firing correlate with dopamine D3 receptor binding affinities.
Topics: Aminoquinolines; Animals; Apomorphine; Azepines; Benzothiazoles; Binding, Competitive; CHO Cells; Cricetinae; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Imidazoles; Male; Neurons; Phenethylamines; Piperidines; Pramipexole; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Substantia Nigra; Tetrahydronaphthalenes; Thiazoles; Thiophenes; Transfection | 1995 |
Opposite modulation by muscarinic M1 and M3 receptors of acetylcholine release from guinea pig ileum as measured directly.
Topics: Acetylcholine; Analysis of Variance; Animals; Bethanechol; Bethanechol Compounds; Chromatography, High Pressure Liquid; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Piperidines; Quinuclidines; Receptors, Muscarinic; Thiophenes | 1993 |
The involvement of protein kinase C in proliferation and differentiation of human keratinocytes--an investigation using inhibitors of protein kinase C.
Topics: Alkaloids; Cell Differentiation; Cell Division; Humans; Indoles; Keratinocytes; Piperidines; Protein Kinase C; Staurosporine; Thiophenes | 1994 |
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory.
Topics: Animals; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Conditioning, Classical; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Memory; Mice; Oxadiazoles; Pain Threshold; Parasympathomimetics; Physostigmine; Piperidines; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 1993 |
The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.
Topics: Antiviral Agents; Binding Sites; Cyclization; Cyclopentanes; HIV Protease; HIV Protease Inhibitors; HIV-1; Isoquinolines; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Quinolines; Saquinavir; Structure-Activity Relationship; Thiophenes | 1994 |
Metabolism and disposition of EXP631--a novel antidepressant analgesic.
Topics: Administration, Oral; Analgesics; Animals; Antidepressive Agents; Dogs; Injections, Intravenous; Male; Piperidines; Rats; Rats, Sprague-Dawley; Thiophenes | 1993 |
Synthesis and evaluation of 1-(1-[5-(2'-[18F]fluoroethyl)-2-thienyl]-cyclohexyl)piperidine as a potential in vivo radioligand for the NMDA receptor-channel complex.
Topics: Animals; Fluorine Radioisotopes; Male; Phencyclidine; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thiophenes; Tissue Distribution; Tomography, Emission-Computed | 1993 |
Synthesis of 3-[18F]fluoromethyl-BTCP and evaluation as a potential PET radioligand for the dopamine transporter in baboons.
Topics: Animals; Brain; Carrier Proteins; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Evaluation Studies as Topic; Fluorine Radioisotopes; Isotope Labeling; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Parkinson Disease; Piperidines; Radioligand Assay; Thiophenes; Tomography, Emission-Computed | 1993 |
Inhibition of LDL oxidation and myeloperoxidase dependent tyrosyl radical formation by the selective estrogen receptor modulator raloxifene (LY139481 HCL).
Topics: Animals; Antioxidants; Copper; Dexamethasone; Estradiol; Estrogen Antagonists; Free Radicals; Horseradish Peroxidase; Humans; Lipoproteins, LDL; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Peroxidase; Phagocytosis; Piperidines; Probucol; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Thiobarbituric Acid Reactive Substances; Thiophenes; Tyrosine | 1996 |
Pharmacological profile of CEB-1957 and atropine toward brain muscarinic receptors and comparative study of their efficacy against sarin poisoning.
Topics: Animals; Atropine; Autoradiography; Binding, Competitive; Brain; Cholinesterase Inhibitors; Male; Muscarinic Antagonists; Parasympatholytics; Piperidines; Pirenzepine; Poisoning; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Sarin; Thiophenes | 1998 |
LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo.
Topics: Animals; Biomechanical Phenomena; Body Weight; Bone and Bones; Cholesterol; Estrogen Antagonists; Female; Organ Size; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Thiophenes; Uterus | 1998 |
LY353381 x HCl: an improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34).
Topics: Animals; Biomechanical Phenomena; Body Weight; Bone Density; Estrogen Antagonists; Female; Humans; Organ Size; Osteoporosis, Postmenopausal; Ovariectomy; Parathyroid Hormone; Piperidines; Rats; Rats, Sprague-Dawley; Thiophenes; Tomography, X-Ray Computed | 1998 |
Discriminative stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO 60-0175: a pharmacological analysis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Conditioning, Operant; Ethylamines; Fluorobenzenes; Indoles; Male; Mianserin; Piperazines; Piperidines; Pyrazines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 1999 |
A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug.
Topics: Administration, Oral; Amides; Animals; Biological Availability; Biological Transport, Active; Caco-2 Cells; Cell Membrane Permeability; Humans; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Liver; Male; Mesenteric Veins; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Rats; Thiophenes | 2000 |
Persistent increase in the amount of aquaporin-5 in the apical plasma membrane of rat parotid acinar cells induced by a muscarinic agonist SNI-2011.
Topics: Animals; Aquaporin 5; Aquaporins; Atropine; Calcium; Cell Membrane; Cells, Cultured; Inositol 1,4,5-Trisphosphate; Male; Membrane Proteins; Muscarinic Agonists; Parotid Gland; Piperidines; Quinuclidines; Rats; Rats, Wistar; Thiophenes | 2000 |
Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha.
Topics: Animals; Benzhydryl Compounds; Blotting, Northern; Estradiol Congeners; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Estrogens, Non-Steroidal; Female; Insulin-Like Growth Factor I; Mice; Mice, Knockout; Mitosis; Ovariectomy; Phenols; Piperidines; Precipitin Tests; Proliferating Cell Nuclear Antigen; Receptors, Estrogen; Ribonucleases; RNA, Messenger; Signal Transduction; Tamoxifen; Thiophenes; Uterus | 2000 |
Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine.
Topics: Amides; Animals; Biological Transport; Caco-2 Cells; Fibrinolytic Agents; Humans; Indicators and Reagents; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Naphthols; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Thiophenes | 2000 |
The oestrogen receptor and its selective modulators in gynaecological oncology.
Topics: Antineoplastic Agents, Hormonal; Cinnamates; Estrogen Antagonists; Female; Genital Neoplasms, Female; Humans; Norpregnenes; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Thiophenes; Toremifene | 2000 |
LY353381.HCl, a selective estrogen receptor modulator, and experimental stroke.
Topics: Animals; Antipyrine; Autoradiography; Brain Ischemia; Carbon Radioisotopes; Cerebral Infarction; Cerebrovascular Circulation; Disease Models, Animal; Estrogen Antagonists; Estrogen Replacement Therapy; Female; Humans; Ovariectomy; Piperidines; Rats; Rats, Wistar; Receptors, Estrogen; Thiophenes | 2000 |
Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cyclic AMP; Cyclopropanes; Fibrinogen; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; In Vitro Techniques; Male; Membrane Proteins; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes | 2001 |
Selective estrogen receptor modulators for the chemoprevention of prostate cancer.
Topics: Age Factors; Androgens; Anticarcinogenic Agents; Estrogen Antagonists; Estrogen Receptor Modulators; Estrogens; Estrogens, Non-Steroidal; Humans; Isoflavones; Male; Phytoestrogens; Piperidines; Plant Preparations; Prostate; Prostatic Neoplasms; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2001 |
Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro.
Topics: Allosteric Regulation; Antihypertensive Agents; Benzothiadiazines; Calcium; Cell Line; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Humans; Piperidines; Receptors, AMPA; Receptors, Glutamate; Recombinant Proteins; Sulfonamides; Thiophenes | 2001 |
Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Female; Hippocampus; Injections, Intravenous; Male; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spinal Cord; Stereotaxic Techniques; Sulfonamides; Thiophenes | 2001 |
Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrospinal Fluid; Female; Muscarinic Agonists; Neurons; Peptide Fragments; Piperidines; Quinuclidines; Rabbits; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiazoles; Thiophenes | 2001 |
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Mice; Mice, Nude; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism.
Topics: Actins; Cells, Cultured; Cytoskeleton; Deoxyglucose; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Gene Expression Regulation; Glucose; Humans; Isoxazoles; Kinetics; Metallothionein; Oligopeptides; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Thiophenes; Transcription, Genetic; Umbilical Veins | 2001 |
Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer.
Topics: Animals; Anticarcinogenic Agents; Binding, Competitive; Cell Division; Drug Interactions; Estradiol; Estradiol Congeners; Estrogen Antagonists; Ethinyl Estradiol; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Uterus | 2001 |
Effects of the new selective estrogen receptor modulator LY353381.HCl (Arzoxifene) on human endometrial cancer growth in athymic mice.
Topics: Animals; Cell Division; Down-Regulation; Endometrial Neoplasms; Estrogen Antagonists; Female; Humans; Mice; Mice, Nude; Piperidines; Receptors, Estrogen; Tamoxifen; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques.
Topics: Animals; Carrier Proteins; Estradiol; Estrogen Antagonists; Estrogen Replacement Therapy; Female; Gene Expression; Macaca mulatta; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Piperidines; Raloxifene Hydrochloride; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Estrogen Receptor Modulators; Serotonin Plasma Membrane Transport Proteins; Thiophenes; Tryptophan Hydroxylase | 2002 |
Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.
Topics: Animals; Anticarcinogenic Agents; Cells, Cultured; Drug Synergism; Drug Therapy, Combination; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Invasiveness; Nicotinic Acids; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Rats; Selective Estrogen Receptor Modulators; Stromal Cells; Tetrahydronaphthalenes; Thiophenes; Transforming Growth Factor beta | 2002 |
Small molecule modulation of Smoothened activity.
Topics: 3T3 Cells; Animals; Benzamides; Benzimidazoles; Binding Sites; Cell Line; Cinnamates; Cyclohexylamines; GTP-Binding Proteins; Hedgehog Proteins; Humans; Mice; Piperazines; Piperidines; Pyrazoles; Pyridines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Smoothened Receptor; Sulfides; Thiophenes; Trans-Activators | 2002 |
Arzoxifene in breast cancer.
Topics: Breast Neoplasms; Double-Blind Method; Female; Humans; Piperidines; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Thiophenes | 2002 |
Long-term dosing of arzoxifene lowers cholesterol, reduces bone turnover, and preserves bone quality in ovariectomized rats.
Topics: Animals; Body Weight; Bone Remodeling; Cholesterol; Female; Ovariectomy; Piperidines; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes | 2002 |
Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.
Topics: Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Isoquinolines; Mice; Neuroprotective Agents; Phenanthrenes; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Thiophenes | 2003 |
Discriminative stimulus properties of (+/-)-fenfluramine: the role of 5-HT2 receptor subtypes.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Fenfluramine; Fluorobenzenes; Indoles; Ketanserin; Male; Piperidines; Pyrazines; Pyridines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reinforcement, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds; Sulfonamides; Thiophenes | 2003 |
HYPOTENSIVES. VI. DISUBSTITUTED ALKYLENEDIAMINES AND RELATED COMPOUNDS.
Topics: Amines; Antihypertensive Agents; Chemistry, Pharmaceutical; Dogs; Ethylenediamines; Pharmacology; Piperidines; Pyridines; Pyrroles; Rats; Research; Thiophenes | 1963 |
DRUGS USED IN THE SYMPTOMATIC TREATMENT OF DIARRHEA.
Topics: Cyclohexanes; Diarrhea; Drug Therapy; Humans; Kaolin; Opium; Parasympatholytics; Pectins; Piperidines; Psyllium; Thiophenes; Toxicology | 1964 |
Effects of long-term administration of N-3 polyunsaturated fatty acids (PUFA) and selective estrogen receptor modulator (SERM) derivatives in ovariectomized (OVX) mice.
Topics: Adipose Tissue; Animals; Body Weight; Bone Marrow Cells; Cholesterol; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Female; Fish Oils; Hypolipidemic Agents; Interleukin-1; Interleukin-10; Interleukin-6; Mice; Mice, Inbred BALB C; Ovariectomy; Ovary; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Skin; Spleen; Thiophenes; Triglycerides; Tumor Necrosis Factor-alpha | 2003 |
Selective estrogen receptor modulators as inhibitors of repopulation of human breast cancer cell lines after chemotherapy.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Methotrexate; Neoplasms, Hormone-Dependent; Piperidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2003 |
Comparison of the selective estrogen receptor modulator arzoxifene (LY353381) with tamoxifen on tumor growth and biomarker expression in an MCF-7 human breast cancer xenograft model.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Female; Humans; Mice; Mice, Nude; Piperidines; Protein Biosynthesis; Proteins; Receptors, Estrogen; Receptors, Progesterone; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Trefoil Factor-1; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2003 |
Construction of arene-fused-piperidine motifs by asymmetric addition of 2-trityloxymethylaryllithiums to nitroalkenes: the asymmetric synthesis of a dopamine D1 full agonist, A-86929.
Topics: Alkenes; Dopamine Agonists; Lithium; Nitro Compounds; Organometallic Compounds; Piperidines; Quinolones; Receptors, Dopamine D1; Stereoisomerism; Thiophenes | 2004 |
The effect of the new SERM arzoxifene on growth and gene expression in MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cathepsin D; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Piperidines; RNA, Messenger; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2004 |
The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Drug Synergism; Mammary Neoplasms, Experimental; NF-kappa B; Nicotinic Acids; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes; Transfection; Transforming Growth Factor beta | 2004 |
A new MCF-7 breast cancer cell line resistant to the arzoxifene metabolite desmethylarzoxifene.
Topics: Breast Neoplasms; Cathepsin D; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 1; Piperidines; Proto-Oncogene Proteins c-bcl-2; Receptors, Progesterone; Repressor Proteins; RNA, Messenger; Tamoxifen; Thiophenes; Transcription Factors | 2004 |
Rexinoids may be ready for prime time in prevention, but challenges remain.
Topics: Animals; Anticarcinogenic Agents; Bexarotene; Breast Neoplasms; Clinical Trials as Topic; Disease Models, Animal; Female; Humans; Nicotinic Acids; Piperidines; Retinoid X Receptors; Tetrahydronaphthalenes; Thiophenes | 2004 |
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
Topics: Alkaline Phosphatase; Animals; Biotransformation; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Estradiol; Female; Glutathione; Humans; Kinetics; Microsomes, Liver; Molecular Structure; Oligodeoxyribonucleotides; Piperidines; Quinones; Rats; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2005 |
Efficient access to 2-aryl-3-substituted benzo[b]thiophenes.
Topics: Cyclization; Molecular Structure; Oxidation-Reduction; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2005 |
Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).
Topics: Amides; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Cell Line; Female; Intestinal Absorption; Jejunum; Mice; Mice, Knockout; Perfusion; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Thiophenes; Transport Vesicles | 2005 |
alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Citalopram; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Idazoxan; In Vitro Techniques; Locus Coeruleus; Male; Methiothepin; Naloxone; Narcotic Antagonists; Neurons; Norepinephrine; Oxazines; Piperazines; Piperidines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 2005 |
Antidepressant-like effects of agomelatine, melatonin and the NK1 receptor antagonist GR205171 in impulsive-related behaviour in rats.
Topics: Acetamides; Animals; Antidepressive Agents; Appetitive Behavior; Conditioning, Operant; Impulsive Behavior; Male; Melatonin; Motivation; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Wistar; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Reinforcement Schedule; Tetrazoles; Thiophenes | 2005 |
Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures.
Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Cerebral Cortex; Cricetinae; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Glucose; Hydrogen Peroxide; Hypoxia; Isoquinolines; Methoxyhydroxyphenylglycol; Mice; Neuroglia; Neurons; Piperidines; Poly(ADP-ribose) Polymerases; Pyridines; Receptors, Metabotropic Glutamate; Thiophenes; Time Factors; Transfection | 2005 |
Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor.
Topics: Animals; Binding, Competitive; Blood Platelets; CHO Cells; Cricetinae; Cricetulus; Cyclopropanes; Dose-Response Relationship, Drug; Humans; Membrane Proteins; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Time Factors; Transfection | 2005 |
Effect of the selective estrogen receptor modulator arzoxifene on repopulation of hormone-responsive breast cancer xenografts between courses of chemotherapy.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Female; Humans; Immunohistochemistry; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Piperidines; Receptors, Estrogen; Thiophenes; Treatment Outcome; Xenograft Model Antitumor Assays | 2005 |
Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator.
Topics: Animals; Cell Proliferation; Cells, Cultured; DNA Damage; Estrogen Receptor Modulators; Estrogens; Genes, Reporter; Humans; Intestine, Small; Microsomes; Molecular Structure; Oxidation-Reduction; Piperidines; Rats; Thiophenes | 2006 |
Exploration of a new type of antimalarial compounds based on febrifugine.
Topics: Animals; Antimalarials; Cell Line; Malaria; Mice; Parasitic Sensitivity Tests; Piperidines; Plasmodium berghei; Plasmodium falciparum; Pyrimidinones; Quinazolines; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Toxicity Tests, Acute | 2006 |
In vitro biological efficiency of tenocyclidine-TCP and its adamantane derivative TAMORF.
Topics: Adamantane; Cell Survival; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromosome Aberrations; Comet Assay; Erythrocytes; Gamma Rays; Humans; In Vitro Techniques; Lethal Dose 50; Leukocytes; Lymphocytes; Morpholines; Mutagens; Phencyclidine; Piperidines; Radiation-Protective Agents; Soman; Structure-Activity Relationship; Thiophenes; Trypan Blue | 2006 |
The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer.
Topics: Animals; Cell Division; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Nicotinic Acids; Piperidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Survival Rate; Tetrahydronaphthalenes; Thiophenes | 2006 |
Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor.
Topics: Amines; Animals; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ion Channels; Male; Mice; Mice, Inbred ICR; Models, Molecular; Phencyclidine; Piperidines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptosomes; Thiophenes | 2007 |
Highly selective 5-substitution of 3-methylthiophene via directed lithiation.
Topics: Lithium; Methylation; Models, Chemical; Organometallic Compounds; Piperidines; Thiophenes | 2007 |
1,1-dioxonaphtho[1,2-b]thiophene-2-methyloxycarbonyl (alpha-Nsmoc) and 3,3-dioxonaphtho[2,1-b]thiophene-2-methyloxycarbonyl (beta-Nsmoc) amino-protecting groups.
Topics: Alcohols; Amino Acids; Chromatography, High Pressure Liquid; Indicators and Reagents; Magnetic Resonance Spectroscopy; Naphthalenes; Piperidines; Thiophenes | 2007 |
Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples.
Topics: Acetylcholine; Animals; Brain Chemistry; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Donepezil; Hippocampus; Indans; Indicators and Reagents; Male; Microdialysis; Neurotransmitter Agents; Piperidines; Rats; Receptors, Serotonin; Reference Standards; Reproducibility of Results; Serotonin Antagonists; Sodium Channel Blockers; Spectrometry, Mass, Electrospray Ionization; Stereotaxic Techniques; Sulfonamides; Tetrodotoxin; Thiophenes | 2007 |
Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity.
Topics: Antioxidants; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Models, Molecular; Oxidation-Reduction; Piperidines; Radioligand Assay; Recombinant Proteins; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2007 |
The new cancer fighter (and other hot drugs on the way).
Topics: Benzodiazepines; Drug Industry; Drugs, Investigational; Herpes Zoster Vaccine; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; Humans; Insulin; Molecular Biology; Papillomavirus Vaccines; Pharmacogenetics; Piperidines; Pyrazoles; Rimonabant; Thiophenes | 2006 |
Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
Topics: Alkylation; Animals; Catalysis; Female; Glutathione; Horseradish Peroxidase; Indolequinones; Microsomes; Piperidines; Quinones; Raloxifene Hydrochloride; Rats; Selective Estrogen Receptor Modulators; Thiophenes; Uterus | 2007 |
Pharmacophore mapping of arylbenzothiophene derivatives for MCF cell inhibition using classical and 3D space modeling approaches.
Topics: Animals; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Models, Molecular; Piperidines; Quantitative Structure-Activity Relationship; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Thiophenes | 2008 |
Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.
Topics: Animals; Female; Lipids; Organ Size; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes; Uterus | 2007 |
Discovery of a new series of potent and selective linear tachykinin NK2 receptor antagonists.
Topics: Administration, Oral; Animals; Caco-2 Cells; Colon; Cyclopentanes; Dipeptides; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Injections; Intestinal Absorption; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Permeability; Piperidines; Pyrans; Radioligand Assay; Receptors, Neurokinin-2; Stereoisomerism; Thiophenes; Urinary Bladder | 2007 |
Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
Topics: Animals; Antioxidants; Breast Neoplasms; Carcinoma, Hepatocellular; Chemoprevention; Female; Humans; Liver; Liver Neoplasms; Luciferases; Mice; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Peroxides; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes; Tumor Cells, Cultured | 2007 |
Tenocyclidine treatment in soman-poisoned rats--intriguing results on genotoxicity versus protection.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Comet Assay; Leukocytes; Male; Models, Chemical; Mutagens; Phencyclidine; Piperidines; Rats; Rats, Wistar; Soman; Thiophenes | 2008 |
AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis.
Topics: Antigens, CD; Antigens, CD34; Blood Platelets; Cells, Cultured; Colony-Forming Units Assay; Flow Cytometry; Humans; Piperidines; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoiesis; Thrombopoietin | 2008 |
Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antag
Topics: Animals; Binding Sites; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Obese; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship; Thiophenes; Weight Loss | 2008 |
Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans].
Topics: Alkylation; Animals; Cyclization; Ligands; Mice; Models, Molecular; Molecular Structure; Oxidation-Reduction; Pain; Piperidines; Protein Binding; Pyrans; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship; Thiophenes | 2008 |
Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Indans; Injections, Spinal; Ligation; Male; Neurotransmitter Uptake Inhibitors; Nootropic Agents; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Postural Balance; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Nerves; Thiophenes | 2008 |
Multifaceted approach to determine the antagonist molecular mechanism and interaction of ibodutant ([1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl)-cyclopentyl]-amide) at the human tachykinin NK2 receptor.
Topics: Animals; Benzamides; Binding, Competitive; Cell Line; Cloning, Molecular; Cricetinae; Cricetulus; Dipeptides; Dose-Response Relationship, Drug; Humans; Kinetics; Models, Molecular; Peptides, Cyclic; Phosphatidylinositols; Piperidines; Protein Binding; Radioligand Assay; Receptors, Neurokinin-2; Thiophenes; Type C Phospholipases | 2009 |
Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.
Topics: Animals; Azides; Biotinylation; Cell Extracts; Cell Line, Tumor; Hepatocytes; Indicators and Reagents; Ligands; Mass Spectrometry; Oxidation-Reduction; Piperidines; Proteins; Quinones; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Staining and Labeling; Thiophenes; Xenobiotics | 2009 |
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).
Topics: Amidohydrolases; Animals; Computer Simulation; Enzyme Inhibitors; Humans; Models, Chemical; Piperazines; Piperidines; Rats; Structure-Activity Relationship; Thiophenes; Urea | 2009 |
Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.
Topics: Cell Line, Tumor; Cell Proliferation; Cyclin D1; Drug Resistance; Estrogen Receptor alpha; Estrogen Receptor Modulators; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; HeLa Cells; Humans; Microscopy, Confocal; Models, Chemical; Piperidines; Thiophenes | 2009 |
Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.
Topics: Animals; Cell Line; Enzyme Inhibitors; Humans; NADH, NADPH Oxidoreductases; Phencyclidine; Piperidines; Structure-Activity Relationship; Thiophenes; Trypanocidal Agents; Trypanosoma brucei brucei | 2009 |
Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Catechols; Cell Line, Tumor; DNA Damage; Female; Gene Deletion; Humans; Hydroquinones; Piperidines; Prodrugs; Protein Binding; Reactive Oxygen Species; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes | 2009 |
Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents.
Topics: Algorithms; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Proliferation; Drug Evaluation, Preclinical; Drug Synergism; Flavonoids; Genes, cdc; Growth Inhibitors; Humans; Irinotecan; Mice; Mice, Nude; Models, Statistical; Neoplasm Transplantation; Piperidines; Predictive Value of Tests; Thiophenes; Urea; Xenograft Model Antitumor Assays | 2010 |
Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency.
Topics: Animals; Cell Line, Transformed; Chromatin Immunoprecipitation; DNA Replication; Enzyme Activation; Ganglia; Gene Expression Regulation, Viral; Green Fluorescent Proteins; Herpesvirus 1, Human; Herpesvirus 3, Human; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Host Cell Factor C1; Humans; Lysine; Mice; Monoamine Oxidase Inhibitors; Mutation; Neurons; Pargyline; Phencyclidine; Piperidines; Promoter Regions, Genetic; Reaction Time; RNA, Small Interfering; Simplexvirus; Thiophenes; Time Factors; Transfection; Virus Replication | 2009 |
Effects of pilocarpine and cevimeline on Ca2+ mobilization in rat parotid acini and ducts.
Topics: Animals; Calcium; Calcium Signaling; Muscarinic Agonists; Muscarinic Antagonists; Parotid Gland; Pilocarpine; Piperidines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 2009 |
Qualitative GC-MS assessment of TCP and TAMORF elimination in rats.
Topics: Adamantane; Animals; Gas Chromatography-Mass Spectrometry; Male; Morpholines; Organophosphate Poisoning; Phencyclidine; Piperidines; Rats; Rats, Wistar; Thiophenes | 2010 |
Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.
Topics: Animals; Atropine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Motility; Gastrointestinal Transit; Guinea Pigs; Ileum; Lower Gastrointestinal Tract; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Oligopeptides; Piperidines; Piroxicam; Prostaglandins; Quinuclidines; Tetrodotoxin; Thiophenes; Upper Gastrointestinal Tract | 2011 |
Impact of metal-induced degradation on the determination of pharmaceutical compound purity and a strategy for mitigation.
Topics: Chromatography, High Pressure Liquid; Copper; Drug Contamination; Drug Stability; Indoles; Iron; Molecular Structure; Pharmaceutical Preparations; Piperidines; Solutions; Solvents; Spectrophotometry, Atomic; Thiophenes | 2011 |
Prevention of breast cancer by newer SERMs in the future.
Topics: Breast Neoplasms; Female; Humans; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes | 2011 |
Selenophene-containing inhibitors of type IIA bacterial topoisomerases.
Topics: Anti-Bacterial Agents; Cell Line, Tumor; DNA Topoisomerase IV; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Methicillin-Resistant Staphylococcus aureus; Organoselenium Compounds; Piperidines; Quinolines; Staphylococcus aureus; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Topoisomerase II Inhibitors | 2011 |
Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2.
Topics: 4-Butyrolactone; Animals; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dibenzocycloheptenes; Dinoprostone; Enzyme Assays; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Isomerases; Lipocalins; Macrophages; Mice; Mice, Inbred C57BL; Piperidines; Prostaglandin D2; Prostaglandin H2; Prostaglandin-E Synthases; Sheep; Thiophenes | 2011 |
EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Partial Agonism; Indans; Male; Memory; Nicotinic Agonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Nicotinic; Thiophenes | 2012 |
Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Breast; Catechols; Cell Line; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Deoxyguanosine; DNA Adducts; Enzyme Induction; Epithelial Cells; Estrogens; Female; Histone Deacetylase Inhibitors; Horses; Humans; Oxidation-Reduction; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes | 2011 |
Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis.
Topics: Acute Disease; Alphavirus; Alphavirus Infections; Animals; Antiviral Agents; Brain; Cell Survival; Encephalitis, Viral; Indoles; Membranes, Artificial; Mice; Microsomes, Liver; Neurons; Permeability; Piperidines; Pyrroles; Replicon; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Viral Tropism; Virus Replication | 2012 |
Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity.
Topics: Animals; Brain; Guinea Pigs; Ligands; Liver; Models, Molecular; Piperidines; Pyrans; Radioligand Assay; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship; Thiophenes | 2012 |
NESS038C6, a novel selective CB1 antagonist agent with anti-obesity activity and improved molecular profile.
Topics: Analysis of Variance; Animals; Anti-Obesity Agents; Blood Glucose; Body Mass Index; Body Weight; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Cholesterol; Dietary Fats; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypothalamus; Indazoles; Intra-Abdominal Fat; Liver; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin Plasma Membrane Transport Proteins; Thiophenes; Transaminases; Triglycerides | 2012 |
Structure-based drug design for dopamine D3 receptor.
Topics: Animals; Combinatorial Chemistry Techniques; Drug Design; Haloperidol; Humans; Indoles; Mice; Models, Molecular; Molecular Structure; Piperazines; Piperidines; Pyrazoles; Pyridines; Receptors, Dopamine D3; Spiperone; Structure-Activity Relationship; Sulpiride; Thiophenes | 2012 |
Preventive therapy for breast cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Humans; Meta-Analysis as Topic; Middle Aged; Piperidines; Preventive Medicine; Pyrrolidines; Raloxifene Hydrochloride; Receptor, ErbB-2; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes | 2012 |
Characterization of ibodutant at NK(2) receptor in human colon.
Topics: Aged; Aged, 80 and over; Benzamides; Binding, Competitive; Colon; Dipeptides; Female; Humans; In Vitro Techniques; Male; Middle Aged; Peptides, Cyclic; Piperidines; Radioligand Assay; Receptors, Neurokinin-2; Thiophenes | 2013 |
Anticancer activity of novel thiophenes containing a biological active diphenylsulfone, diazepin, piperidine, oxazepine, acryladehyde and sulfonamide moieties.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Oxazepines; Piperidines; Sulfonamides; Thiophenes | 2013 |
Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Data Interpretation, Statistical; Dizocilpine Maleate; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorobenzenes; Haloperidol; Male; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reflex, Startle; Risperidone; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Sulfonamides; Thiophenes | 2014 |
An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk.
Topics: Animals; Anticoagulants; Cell Hypoxia; Estrogen Receptor alpha; Estrogen Receptor beta; Glucose; Male; Memory; Mice; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nootropic Agents; Piperidines; Primary Cell Culture; Rats; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA, Small Interfering; Selective Estrogen Receptor Modulators; Thiophenes; Vasodilation | 2013 |
A new fluorescence "off-on" chemodosimeter for L-cysteine based on water-soluble polythiophene.
Topics: Biological Assay; Chlorides; Cysteine; Fluorescent Dyes; Gold Compounds; Humans; Piperidines; Sensitivity and Specificity; Spectrometry, Fluorescence; Thiophenes | 2013 |
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex.
Topics: Animals; Benzodiazepines; Benzoxazines; Central Nervous System Agents; Electric Stimulation; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Synaptic Transmission; Thiophenes | 2014 |
SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites.
Topics: Cell Transformation, Neoplastic; Cells, Cultured; Cytoprotection; Estradiol; Humans; Inactivation, Metabolic; Indoles; Mammary Glands, Human; MCF-7 Cells; Oxidants; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Reactive Oxygen Species; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Up-Regulation | 2014 |
Electronic structure, novel synthesis, and O-H...O and C-H...O interactions in two 6-oxopiperidine-2-carboxylic acid derivatives.
Topics: Carboxylic Acids; Crystallography, X-Ray; Hydrogen Bonding; Molecular Structure; Pipecolic Acids; Piperidines; Thiophenes | 2014 |
A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Anti-Obesity Agents; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eating; Energy Metabolism; Fatty Liver; Ion Channels; Lipolysis; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Thermogenesis; Thiophenes; Uncoupling Protein 1; Weight Loss | 2015 |
BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs.
Topics: Animals; Blood Proteins; Brain; Cell Line; Guinea Pigs; Humans; Indoles; Male; Piperazines; Piperidines; Receptor, Serotonin, 5-HT2B; Serotonin 5-HT2 Receptor Antagonists; Substrate Specificity; Thiophenes; Thioxanthenes; Xanthenes | 2015 |
Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors.
Topics: Animals; Aripiprazole; Boron Compounds; Dose-Response Relationship, Drug; Drug Synergism; Fluorobenzenes; HSP90 Heat-Shock Proteins; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Nerve Growth Factor; Neurites; Oxazoles; PC12 Cells; Piperazines; Piperidines; Pyridines; Quinolones; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Serotonin Agents; Thiophenes | 2015 |
Synthesis of the alkylated active metabolite of tipidogrel.
Topics: Alkylation; Animals; Chromatography, High Pressure Liquid; Clopidogrel; Half-Life; Piperidines; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2Y12; Tandem Mass Spectrometry; Thiophenes; Ticlopidine | 2015 |
Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.
Topics: Animals; Antihypertensive Agents; Carbon Disulfide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, Animal; Glaucoma; Humans; Intraocular Pressure; Male; Molecular Docking Simulation; Morpholines; Piperazines; Piperidines; Quinuclidines; Rabbits; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Thiocarbamates; Thiophenes | 2015 |
Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances.
Topics: Analysis of Variance; Aniline Compounds; Animals; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Memory; Mice; Motor Activity; Piperidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Serotonin Antagonists; Sulfonamides; Thiophenes; Time Factors | 2015 |
Fragment Binding Can Be Either More Enthalpy-Driven or Entropy-Driven: Crystal Structures and Residual Hydration Patterns Suggest Why.
Topics: Amidines; Crystallography, X-Ray; Entropy; Hirudins; Humans; Ligands; Models, Molecular; Molecular Structure; Peptide Fragments; Piperidines; Protein Binding; Structure-Activity Relationship; Thermodynamics; Thiophenes; Thrombin; Water | 2015 |
Structural features underlying raloxifene's biophysical interaction with bone matrix.
Topics: Animals; Bone Matrix; Collagen; Dogs; Durapatite; Femur; Hydrophobic and Hydrophilic Interactions; Male; Piperidines; Polylysine; Protein Binding; Raloxifene Hydrochloride; Receptors, Estrogen; Static Electricity; Structure-Activity Relationship; Thiophenes | 2016 |
Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators.
Topics: Animals; Antineoplastic Agents, Hormonal; Carcinoma in Situ; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Estrogen Antagonists; Estrogens; Fallopian Tubes; Female; Gene Expression Regulation, Neoplastic; Genome; Humans; Mice; Neoplasms, Cystic, Mucinous, and Serous; Ovarian Neoplasms; Piperidines; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen; Thiophenes; Transcriptome | 2016 |
Incidence of vertebral fractures in calcium and vitamin D-supplemented postmenopausal Brazilian women with osteopenia or osteoporosis: data from Arzoxifene Generations Trial.
Topics: Age Distribution; Aged; Aged, 80 and over; Bone Diseases, Metabolic; Brazil; Calcium; Dietary Supplements; Female; Follow-Up Studies; Humans; Incidence; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Postmenopause; Randomized Controlled Trials as Topic; Risk Factors; Spinal Fractures; Thiophenes; Vitamin D | 2016 |
Click-based synthesis and antitubercular evaluation of novel dibenzo[b,d]thiophene-1,2,3-triazoles with piperidine, piperazine, morpholine and thiomorpholine appendages.
Topics: Antitubercular Agents; Cell Survival; Click Chemistry; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Morpholines; Mycobacterium tuberculosis; Piperazine; Piperazines; Piperidines; Structure-Activity Relationship; Thiophenes; Triazoles | 2016 |
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
Topics: Allosteric Regulation; Animals; Brain; Humans; Microsomes, Liver; Piperidines; Pyrimidines; Quinazolines; Rats; Receptor, Muscarinic M4; Structure-Activity Relationship; Thiophenes | 2016 |
Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon β1-integrin function.
Topics: Animals; Animals, Newborn; Benzodioxoles; Dipeptides; Disks Large Homolog 4 Protein; Estrogen Receptor Modulators; Estrogens; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation; Guanylate Kinases; Hippocampus; Integrin beta1; Integrins; Male; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mice, Knockout; Neurons; Phenylalanine; Piperidines; Pyrazoles; Pyrimidines; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Thiophenes | 2016 |
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.
Topics: Blood-Brain Barrier; Drug Design; Piperidines; Pyridines; Spectrum Analysis; Tetrahydroisoquinolines; Thiophenes | 2016 |
α7-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Donepezil; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; GABA Agents; GABAergic Neurons; Hippocampus; Humans; Indans; Inhibitory Postsynaptic Potentials; Male; Nerve Net; Nicotinic Agonists; Oocytes; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Thiophenes; Xenopus laevis | 2016 |
Rosbin, a synthetic small molecule, induces A549 cells apoptosis through a ROS-mediated pathway.
Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Caspase 9; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Mitochondria; Piperidines; Reactive Oxygen Species; Thiophenes | 2017 |
A novel urotensin II receptor antagonist, KR-36996, improved cardiac function and attenuated cardiac hypertrophy in experimental heart failure.
Topics: Animals; Body Weight; Cardiomegaly; Cell Line; Chronic Disease; Electrocardiography; Heart; Heart Failure; Hemodynamics; Humans; Male; Mice; Myocardium; Organ Size; Piperidines; Pressure; Rats; Receptors, G-Protein-Coupled; Substrate Specificity; Thiophenes | 2017 |
Electrostimulated Release of Neutral Drugs from Polythiophene Nanoparticles: Smart Regulation of Drug-Polymer Interactions.
Topics: Alkaloids; Benzodioxoles; Bridged Bicyclo Compounds, Heterocyclic; Curcumin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Nanoparticles; Particle Size; Piperidines; Polymers; Polyunsaturated Alkamides; Thiophenes | 2017 |
Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; Dosage Compensation, Genetic; Embryo, Nonmammalian; Gene Expression Regulation; Jumonji Domain-Containing Histone Demethylases; Models, Molecular; Mutation; Piperidines; Sequence Alignment; Thiophenes; X Chromosome | 2017 |
Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Donepezil; Indans; Macaca fascicularis; Male; Paired-Associate Learning; Piperidines; Quinuclidines; Reaction Time; Scopolamine; Space Perception; Spiro Compounds; Task Performance and Analysis; Thiophenes; Treatment Outcome; Visual Perception | 2017 |
The future of type 1 cannabinoid receptor allosteric ligands.
Topics: Allosteric Site; Animals; Humans; Indoles; Ligands; Models, Molecular; Phenylurea Compounds; Piperidines; Pyridines; Receptor, Cannabinoid, CB1; Small Molecule Libraries; Thiophenes | 2018 |
5-HT
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; HeLa Cells; Humans; Male; Maze Learning; Memory; Mice, Inbred ICR; Nootropic Agents; Piperidines; Pyridones; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Thiophenes; Vilazodone Hydrochloride | 2018 |
Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.
Topics: Amides; Animals; Cartilage, Articular; Cattle; Chondrocytes; Collagen Type II; Extracellular Matrix Proteins; Imidazoles; Osteoarthritis; Oxazines; Piperidines; Proteoglycans; Pyridines; Pyrimidines; Pyrroles; Thiophenes | 2019 |
Discovery of an intrasubunit nicotinic acetylcholine receptor-binding site for the positive allosteric modulator Br-PBTC.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Humans; Kinetics; Molecular Docking Simulation; Mutagenesis, Site-Directed; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Piperidines; Protein Structure, Tertiary; Protein Subunits; Receptors, Nicotinic; Recombinant Proteins; Sequence Alignment; Thiophenes; Xenopus laevis | 2019 |
A Pharmacodynamic Study of CN-218, a Novel Antiplatelet and Antithrombotic Agent Primarily Targeting the P2Y
Topics: Animals; Blood Coagulation; Blood Platelets; Carrageenan; Clopidogrel; Cyclic AMP; Disease Models, Animal; Fibrinolytic Agents; Hemorrhage; Male; Mice; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Rats, Wistar; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis | 2020 |
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.
Topics: Benzimidazoles; beta-Arrestins; HEK293 Cells; Humans; Piperidines; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Urea | 2020 |
Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Piperidines; Proteasome Endopeptidase Complex; Proteolysis; Signal Transduction; Thiophenes; Ubiquitin Thiolesterase | 2021 |
Avatrombopag Optimizes Response to Niraparib by Managing Thrombocytopenia Associated with Poly-ADP Ribose Polymerase (PARP) Inhibition in Ovarian Cancer and Breast Cancer: A Case Series.
Topics: Adenosine Diphosphate Ribose; Breast Neoplasms; Female; Humans; Indazoles; Ovarian Neoplasms; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thiazoles; Thiophenes; Thrombocytopenia | 2020 |
Small Molecule Inhibitors Targeting Nuclear Factor κB Activation Markedly Reduce Expression of Interleukin-2, but Not Interferon-γ, Induced by Phorbol Esters and Calcium Ionophores.
Topics: Amides; Animals; Calcium Ionophores; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Interferon-gamma; Interleukin-2; Mice; NF-kappa B; Piperidines; Primary Cell Culture; Promoter Regions, Genetic; Pyrrolidines; Small Molecule Libraries; T-Box Domain Proteins; Tetradecanoylphorbol Acetate; Thiophenes | 2021 |