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thiophenes and pf-4778574

thiophenes has been researched along with pf-4778574 in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Castner, SA; Holden, DE; Menniti, FS; Roberts, BM; Schmidt, CJ; Seymour, PA; Shaffer, CL; Williams, GV1
Doran, AC; Mancuso, JY; Osgood, SM; Shaffer, CL1
Bryce, DK; Hajós, M; Hanks, AN; Hoffmann, WE; Hurst, RS; Lazzaro, JT; Liu, J; Lotarski, S; Menniti, FS; Osgood, SM; Schmidt, CJ; Scialis, RJ; Shaffer, CL; Weber, ML1
Chen, X; Li, S; Lv, D; Shen, M; Wang, C; Wang, Z; Zhang, Y; Zhao, C1

Other Studies

4 other study(ies) available for thiophenes and pf-4778574

ArticleYear
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction.
    Behavioural brain research, 2010, Sep-01, Volume: 212, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Area Under Curve; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Ketamine; Macaca fascicularis; Macaca mulatta; Memory Disorders; Memory, Short-Term; Motor Activity; Neuropsychological Tests; Reaction Time; Sulfonamides; Thiophenes; Time Factors

2010
An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Brain Chemistry; Dogs; Isoxazoles; Male; Paliperidone Palmitate; Primates; Pyrimidines; Rats; Rats, Sprague-Dawley; Risperidone; Thiophenes

2012
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 347, Issue:1

    Topics: Allosteric Regulation; Animals; Cells, Cultured; Dogs; Excitatory Amino Acid Agonists; Female; HEK293 Cells; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Psychomotor Performance; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Seizures; Thiophenes; Treatment Outcome

2013
Positive Allosteric Modulation of AMPAR by PF-4778574 Produced Rapid Onset Antidepressant Actions in Mice.
    Cerebral cortex (New York, N.Y. : 1991), 2019, 09-13, Volume: 29, Issue:10

    Topics: Allosteric Regulation; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Gene Expression; Male; Membrane Glycoproteins; Mice, Inbred ICR; Nerve Growth Factors; Prefrontal Cortex; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Receptors, AMPA; Signal Transduction; Stress, Psychological; Thiophenes

2019