thiophenes has been researched along with pemetrexed in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (24.44) | 18.2507 |
| 2000's | 22 (48.89) | 29.6817 |
| 2010's | 10 (22.22) | 24.3611 |
| 2020's | 2 (4.44) | 2.80 |
| Authors | Studies |
|---|---|
| Bonmassar, E; Lu, K; McGuire, JJ; Rustum, YM; Yin, MB | 1 |
| Calvert, AH; Jackman, AL | 1 |
| Hanauske, AR | 1 |
| Andis, SL; Beardsley, GP; Bewley, JR; Chen, VJ; Gates, SB; Gossett, LS; Habeck, LL; Kohler, W; MacKellar, WC; Mendelsohn, LG; Moroson, BA; Patel, VF; Ratnam, M; Rayl, EA; Schultz, RM; Shackelford, KA; Shih, C; Soose, DJ | 1 |
| Takimoto, CH | 1 |
| Andis, SL; Bewley, JR; Chen, VJ; Iversen, PW; Mendelsohn, LG; Schultz, RM; Seitz, DE; Shih, C; Tonkinson, JL | 2 |
| Adjei, AA | 1 |
| Bewley, JR; Chen, VJ; Dempsey, JA; Roberts, EF; Schultz, RM; Shih, C | 1 |
| Danenberg, PV; Malli, H; Swenson, S | 1 |
| Allay, JA; Belt, JA; Patel, DH; Sorrentino, BP | 1 |
| Kuiper, CM; Peters, GJ; van der Wilt, CL | 1 |
| Aherne, GW; Brunton, L; Jackman, AL; Monaghan, P; Titley, J; Valenti, M; Welsh, SJ | 1 |
| Cassidy, J | 1 |
| Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
| Curtin, NJ; Errington, J; Lu, X; Lunec, J; Newell, DR | 1 |
| Backus, HH; Kuiper, CM; Peters, GJ; Pinedo, HM; van der Wilt, CL; van Groeningen, CJ; Wouters, D | 1 |
| Fizazi, K; John, WJ; Vogelzang, NJ | 1 |
| Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH | 1 |
| Vogelzang, NJ | 1 |
| Jackman, AL; Theti, DS | 1 |
| Chattopadhyay, S; Goldman, ID; Hanscom, M; Zhao, R | 1 |
| Goldman, ID; Wang, Y; Zhao, R | 1 |
| Klabatsa, A; Steele, JP | 1 |
| Chattopadhyay, S; Goldman, ID; Krupenko, N; Krupenko, SA; Zhao, R | 1 |
| Garcia-Carbonero, R; Paz-Ares, L | 1 |
| Aelony, Y | 1 |
| Davies, AM; Ellis, P; Evans, WK; Haynes, AE; Lloyd, NS | 1 |
| Bijnsdorp, IV; Comijn, EM; Gmeiner, WH; Padron, JM; Peters, GJ | 1 |
| Burkitt, V | 1 |
| Gatzemeier, U; Heigener, DF; Reck, M | 1 |
| Anraku, M; Bezjak, A; Burkes, R; Cho, BC; de Perrot, M; Feld, R; Johnston, MR; Keshavjee, S; Leighl, N; Roberts, H; Tsao, MS | 1 |
| De Vincenzo, F; Santoro, A; Simonelli, M; Zucali, PA | 1 |
| Paracha, N; Scott, DA; Thatcher, N; Woods, B | 1 |
| Grosso, F; Scagliotti, GV | 1 |
| Agarwal, V; Cawkwell, L; Eagle, GL; Hodgkinson, VC; Lind, MJ; Scaife, L | 1 |
| Guan, W; Hu, J; Liu, B; Qian, X; Shen, J; Wang, H; Wei, J; Xie, L; Yu, L; Zhang, Q | 1 |
| Beer, DG; Bergeron, EJ; Chen, G; Giordano, TJ; Grabauskiene, S; Morgan, MA; Reddy, RM; Thomas, DG | 1 |
| Goldman, ID; Visentin, M; Zhao, R | 1 |
| Rzymowska, J; Sztanke, K; Sztanke, M | 1 |
| Dann, CE; Deis, SM; Gangjee, A; George, C; Hou, Z; Kushner, J; Matherly, LH; Mitchell-Ryan, S; O'Connor, C; Orr, S; Polin, L; Raghavan, S; Wallace, A; Wang, L; White, K; Wilson, MR; Yang, S | 1 |
| Aguilar-Bonavides, C; Behrens, C; Çeliktas, M; Delgado, O; Dennison, JB; Dhillon, D; Do, KA; Fahrmann, JF; Gazdar, AF; Hanash, SM; Ostrin, EJ; Taguchi, A; Tanaka, I; Tripathi, SC; Villalobos, P; Wang, H | 1 |
| Cherubini, C; Drudi, F; Fantini, M; Lazzari-Agli, L; Papi, M; Sartori, S; Tamburini, E; Tassinari, D | 1 |
| Chambers, C; Giani, J; Sawyer, MB | 1 |
| Charushin, VN; Kovalev, IS; Majee, A; Santra, S; Varaksin, MV; Zyryanov, GV | 1 |
16 review(s) available for thiophenes and pemetrexed
| Article | Year |
|---|---|
Folate-based thymidylate synthase inhibitors as anticancer drugs.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 1995 |
The development of new chemotherapeutic agents.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Irinotecan; Neoplasms; Pemetrexed; Quinazolines; Thiophenes; Trimetrexate | 1996 |
Antifolates in clinical development.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1997 |
A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer.
Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Glutamates; Guanine; Humans; Pemetrexed; Platinum Compounds; Pyridines; Quinazolines; Tegafur; Thiophenes; Uracil | 1999 |
Thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 1999 |
Thymidylate synthase inhibitors in colorectal cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 2000 |
The emerging role of antifolates in the treatment of malignant pleural mesothelioma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Folic Acid Antagonists; Glutamates; Guanine; Humans; Mesothelioma; Organoplatinum Compounds; Oxaliplatin; Pemetrexed; Pleural Neoplasms; Quinazolines; Thiophenes | 2002 |
Emerging insights into the biology and therapy of malignant mesothelioma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Folic Acid Antagonists; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase | 2002 |
Chemotherapy options and new advances in malignant pleural mesothelioma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Palliative Care; Pemetrexed; Pleural Neoplasms; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes | 2005 |
Systemic chemotherapy in the management of malignant peritoneal mesothelioma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Peritoneal Neoplasms; Quinazolines; Thiophenes; Vinblastine; Vinorelbine | 2006 |
The use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Female; Glutamates; Guanine; Humans; Male; Maximum Tolerated Dose; Mesothelioma; Neoplasm Invasiveness; Patient Selection; Pemetrexed; Pleural Neoplasms; Practice Guidelines as Topic; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes; Treatment Outcome | 2006 |
[Chemotherapy of malignant pleural mesothelioma: have we made any progress?].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Glutamates; Guanine; Humans; Mesothelioma; Neoplasm Staging; Pemetrexed; Pleural Neoplasms; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Retreatment; Thiophenes | 2008 |
Future developments in the management of malignant pleural mesothelioma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cisplatin; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Diagnostic Imaging; Disease Management; Drug Delivery Systems; Forecasting; Glutamates; Guanine; Humans; Mesothelioma; Mice; Multicenter Studies as Topic; Neoplasm Proteins; Neoplasm Staging; Pemetrexed; Pleural Neoplasms; Quinazolines; Radiotherapy, Intensity-Modulated; Randomized Controlled Trials as Topic; Thiophenes; Thoracic Surgical Procedures; Vinblastine; Vinorelbine | 2009 |
Systemic treatment of malignant pleural mesothelioma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Pleura; Pleural Neoplasms; Quinazolines; Thiophenes; Treatment Outcome | 2012 |
Antimetabolites in the treatment of advanced pleural mesothelioma: a network meta-analysis of randomized clinical trials.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Network Meta-Analysis; Pemetrexed; Pleural Neoplasms; Quinazolines; Thiophenes; Treatment Outcome | 2017 |
Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities.
Topics: Antimetabolites; Folic Acid; Folic Acid Antagonists; Methotrexate; Pemetrexed; Quinazolines; Thiophenes | 2022 |
29 other study(ies) available for thiophenes and pemetrexed
| Article | Year |
|---|---|
Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
Topics: Cell Division; Cell-Free System; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Pemetrexed; Peptide Synthases; Pteroylpolyglutamic Acids; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured | 1995 |
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Acyltransferases; Aminohydrolases; Antimetabolites, Antineoplastic; Folic Acid Antagonists; Formate-Tetrahydrofolate Ligase; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Molecular Structure; Multienzyme Complexes; Oxidoreductases; Pemetrexed; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Nucleotides; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.
Topics: Acid Anhydride Hydrolases; Antimetabolites, Antineoplastic; Deoxyribonucleotides; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Nucleoside-Diphosphate Kinase; Nucleoside-Triphosphatase; Pemetrexed; Quinazolines; Ribonucleotides; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1999 |
Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells.
Topics: 3T3 Cells; Animals; Bone Marrow Cells; Carrier Proteins; Cell Death; DNA, Complementary; Drug Resistance; Drug Synergism; Equilibrative-Nucleoside Transporter 2; Female; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Vectors; Glutamates; Guanine; Hematopoietic Stem Cells; Membrane Proteins; Mice; Mice, Inbred C57BL; Pemetrexed; Quinazolines; Retroviridae; Thioinosine; Thiophenes | 2000 |
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; DNA Damage; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Flow Cytometry; Fluorouracil; Glutamates; Guanine; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Mice; Mice, Inbred DBA; Microscopy, Confocal; Neoplasm Transplantation; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured; Up-Regulation | 2000 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
The impact of p53 status on cellular sensitivity to antifolate drugs.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Mutational Analysis; DNA, Neoplasm; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Genotype; Glutamates; Guanine; Humans; Methotrexate; Mutation; Pemetrexed; Quinazolines; Sensitivity and Specificity; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Thymidylate synthase inhibition induces p53 dependent and independent cell death.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; DNA Damage; Enzyme Inhibitors; Fas Ligand Protein; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Membrane Glycoproteins; Pemetrexed; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Models, Chemical; Neoplasms; Pemetrexed; Quinazolines; Receptors, Cell Surface; Thiophenes; Time Factors | 2004 |
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Division; Drug Resistance, Neoplasm; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Membrane Transport Proteins; Ornithine; Pemetrexed; Polyglutamic Acid; Pterins; Quinazolines; Reduced Folate Carrier Protein; Thiophenes | 2004 |
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Blotting, Northern; Carrier Proteins; Cell Line; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Membrane Transport Proteins; Methotrexate; Pemetrexed; Protein Isoforms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; RNA; Thiophenes; Time Factors; Transfection; Trimetrexate | 2004 |
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Topics: Amino Acid Substitution; Antineoplastic Agents; Arginine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Glutamates; Glycine; Guanine; Humans; Leucovorin; Methotrexate; Mutation; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Purines; Pyrimidines; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 2006 |
Raltitrexed and pemetrexed studies in mesothelioma have not shown improved quality of life nor prolonged survival compared with effective pleurodesis with thoracoscopic talc poudrage.
Topics: Cisplatin; Clinical Trials as Topic; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Pleural Neoplasms; Pleurodesis; Quality of Life; Quinazolines; Talc; Thiophenes; Treatment Outcome | 2006 |
Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2007 |
In Australia, patients and government at odds over mesothelioma treatment costs.
Topics: Abdominal Neoplasms; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asbestos; Australia; Canada; Carcinogens; Cisplatin; Cost-Benefit Analysis; Environmental Exposure; Glutamates; Government; Guanine; Health Care Costs; Humans; Incidence; Lobbying; Lung Neoplasms; Mesothelioma; Patient Advocacy; Pemetrexed; Quinazolines; Thiophenes; Thoracic Neoplasms; United Kingdom | 2007 |
Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Glutamates; Guanine; Humans; Male; Mesothelioma; Middle Aged; Neoadjuvant Therapy; Pemetrexed; Pleural Neoplasms; Pneumonectomy; Quinazolines; Radiotherapy, Adjuvant; Remission Induction; Retrospective Studies; Thiophenes; Vinblastine; Vinorelbine | 2009 |
Raltitrexed plus cisplatin is cost-effective compared with pemetrexed plus cisplatin in patients with malignant pleural mesothelioma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cost-Benefit Analysis; Glutamates; Guanine; Health Care Costs; Humans; Mesothelioma; Pemetrexed; Pleural Neoplasms; Quality-Adjusted Life Years; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes | 2012 |
Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Pemetrexed; Protein Array Analysis; Proteomics; Thiophenes | 2013 |
TS mRNA levels can predict pemetrexed and raltitrexed sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; Fluorouracil; Glutamates; Guanine; Humans; Immunohistochemistry; Male; Middle Aged; Pemetrexed; Predictive Value of Tests; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase | 2014 |
Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Protein Kinase Inhibitors; Protein Kinases; Thiophenes; Urea | 2014 |
Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.
Topics: Cell Line, Tumor; Endocytosis; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Quinazolines; Reduced Folate Carrier Protein; Thiophenes | 2015 |
Synthesis, structure elucidation and identification of antiproliferative activities of a novel class of thiophene bioisosteres bearing the privileged 7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one scaffold.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Imidazoles; Inhibitory Concentration 50; Pemetrexed; Structure-Activity Relationship; Thiophenes; Triazines | 2015 |
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; CHO Cells; Cricetulus; Crystallography, X-Ray; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Folate Receptor 1; Folic Acid Antagonists; Heterografts; Humans; Mice, SCID; Models, Molecular; Neoplasm Transplantation; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Proton-Coupled Folate Transporter; Pyrimidines; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Thiophenes | 2015 |
Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma.
Topics: Adenocarcinoma; Aged; AMP-Activated Protein Kinase Kinases; Carbamoyl-Phosphate Synthase (Ammonia); Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Female; Gemcitabine; Gene Knockdown Techniques; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Metabolic Networks and Pathways; Metabolome; Middle Aged; Pemetrexed; Prognosis; Proportional Hazards Models; Protein Serine-Threonine Kinases; Proteome; RNA, Messenger; Signal Transduction; Survival Rate; Thiophenes; Tissue Array Analysis; Urea | 2017 |
Tolerability of pemetrexed and oxaliplatin in the treatment of stage III colon cancer during raltitrexed shortage.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Canada; Colonic Neoplasms; Female; Humans; Kidney Diseases; Middle Aged; Oxaliplatin; Pemetrexed; Quinazolines; Thiophenes; Tomography, X-Ray Computed; Treatment Outcome | 2021 |