thiophenes has been researched along with p5091 in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (62.50) | 24.3611 |
| 2020's | 6 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Altun, M; Anderson, KC; Carrasco, R; Chauhan, D; Fulcinniti, M; Hideshima, T; Kessler, BM; Kingsbury, WD; Kodrasov, MP; Kumar, KG; Leach, CA; McDermott, JL; Minvielle, S; Munshi, N; Nicholson, B; Orlowski, R; Richardson, P; Shah, PK; Tian, Z; Weinstock, J; Zhou, B | 1 |
| Celetti, A; Cerrato, A; Guggino, G; Ilardi, G; Malapelle, U; Merolla, F; Monaco, G; Monaco, R; Morra, F; Napolitano, V; Staibano, S; Troncone, G; Visconti, R | 1 |
| An, T; Gong, L; Gong, Y; Kong, L; Li, X; Li, Y; Liu, J; Ma, P; Mao, B; Yu, C; Zhou, H; Zhu, H | 1 |
| Ahmad, S; Ali, A; Banerjea, AC; Farooqui, SR; Raja, R | 1 |
| Kang, L; Liu, H; Luan, X; Shi, Y; Sun, Y; Wang, M; Wang, S; Wang, T; Wang, Y; Zhang, J; Zhang, Y; Zhou, Z; Zou, Z | 1 |
| Anderson, KC; Buhrlage, SJ; Chauhan, D; Das, D; Dhe-Paganon, S; Engen, JR; Hu, W; Iacob, RE; Lamberto, I; Liu, X; Mikhailova, T; Schauer, NJ; Seo, HS; Weisberg, EL | 1 |
| Gu, W; Sun, H; Tavana, O | 1 |
| Chen, P; Dong, Z; Hu, T; Li, M; Li, P; Liu, X; Liu, Z; Sha, B; Wang, L; Zhang, J; Zhang, Y | 1 |
| Celetti, A; Cerrato, A; Criscuolo, D; Giannella, R; Ilardi, G; Insabato, L; Merolla, F; Morra, F; Staibano, S; Visconti, R | 1 |
| Chen, X; Fu, Q; Liu, J; Lv, H; Miao, Y; Qian, F; Qian, G; Qian, L; Wang, J; Wang, X; Yu, Z; Yuan, Y; Zeng, C; Zheng, H | 1 |
| Cao, T; Fu, Y; Gao, Y; Li, X; Liu, Y; Peng, Y; Qi, X; Yin, L; Yuan, B; Zhang, S; Zhu, Q | 1 |
| Cao, B; He, Y; Jiang, S; Mao, X; Moran, MF; Tong, J; Wang, S; Xu, Y; Yang, Y; Zeng, Y; Zhang, Z | 1 |
| Budamagunta, V; Campisi, J; He, Y; Li, W; Lv, D; Ortiz, YT; Zhang, X; Zheng, G; Zhou, D | 1 |
| Deng, J; Liang, L; Liu, J; Nie, L; Su, T; Yang, Z; Yi, H | 1 |
| Huang, XY; Quan, YF; Yan, LL; Zhao, L | 1 |
| Bertalot, G; Bonaldi, T; Bossi, D; Confalonieri, S; Cuomo, A; Giardina, G; Granieri, L; Lanfrancone, L; Marocchi, F; Melixetian, M; Mohammadi, N; Nicoli, P; Pisati, F | 1 |
16 other study(ies) available for thiophenes and p5091
| Article | Year |
|---|---|
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Dexamethasone; Drug Resistance, Neoplasm; Drug Therapy, Combination; Humans; Lenalidomide; Mice; Mice, SCID; Molecular Sequence Data; Multiple Myeloma; Neovascularization, Pathologic; Protease Inhibitors; Proto-Oncogene Proteins c-mdm2; Pyrazines; Random Allocation; Thalidomide; Thiophenes; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7; Xenograft Model Antitumor Assays | 2012 |
USP7 inhibitors, downregulating CCDC6, sensitize lung neuroendocrine cancer cells to PARP-inhibitor drugs.
Topics: Aged; Aged, 80 and over; AMP-Activated Protein Kinase Kinases; Antineoplastic Agents; Carcinoma, Neuroendocrine; Cisplatin; Cytoskeletal Proteins; Down-Regulation; Female; Genes, p53; Genes, Tumor Suppressor; High-Throughput Nucleotide Sequencing; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Neuroendocrine Tumors; Poly(ADP-ribose) Polymerase Inhibitors; Polymorphism, Single Nucleotide; Predictive Value of Tests; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Thiophenes; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7 | 2017 |
USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth.
Topics: beta Catenin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; HEK293 Cells; Humans; Prognosis; Signal Transduction; Thiophenes; Transcription, Genetic; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7; Ubiquitination; Wnt Proteins | 2017 |
USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein.
Topics: Aminopyridines; Anti-HIV Agents; Cell Line; CRISPR-Cas Systems; Enzyme Induction; Enzyme Inhibitors; Genes, Reporter; HEK293 Cells; HIV-1; Host-Pathogen Interactions; Humans; Jurkat Cells; Protein Stability; Recombinant Fusion Proteins; T-Lymphocytes; tat Gene Products, Human Immunodeficiency Virus; Thiocyanates; Thiophenes; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7; Ubiquitination; Virus Replication | 2017 |
The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status.
Topics: Apoptosis; Autophagy; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Proliferation; Female; Flow Cytometry; Humans; Microscopy, Phase-Contrast; Ovarian Neoplasms; p21-Activated Kinases; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Thiophenes; Tumor Suppressor Protein p53; Ubiquitin-Specific Peptidase 7 | 2017 |
Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Topics: Catalytic Domain; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Protease Inhibitors; Structure-Activity Relationship; Substrate Specificity; Thiophenes; Ubiquitin; Ubiquitin-Specific Peptidase 7 | 2017 |
Targeting HAUSP in both p53 wildtype and p53-mutant tumors.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Imidazoles; Indenes; Molecular Targeted Therapy; N-Myc Proto-Oncogene Protein; Neurons; Piperazines; Protease Inhibitors; Protein Stability; Proto-Oncogene Proteins c-mdm2; Pyrazines; RNA, Small Interfering; Signal Transduction; Thiophenes; Tumor Suppressor Protein p53; Ubiquitin-Specific Peptidase 7 | 2018 |
Targeting the overexpressed USP7 inhibits esophageal squamous cell carcinoma cell growth by inducing NOXA-mediated apoptosis.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Cell Proliferation; Esophageal Neoplasms; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Prognosis; Proto-Oncogene Proteins c-bcl-2; Thiophenes; Tumor Cells, Cultured; Ubiquitin-Specific Peptidase 7; Xenograft Model Antitumor Assays | 2019 |
CCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer.
Topics: Antineoplastic Agents; Azetidines; Biomarkers, Tumor; Cell Line, Tumor; Cytoskeletal Proteins; DNA Damage; Genes, Tumor Suppressor; Humans; Nitro Compounds; Poly(ADP-ribose) Polymerase Inhibitors; Thiophenes; Ubiquitin-Specific Peptidase 7; Urinary Bladder Neoplasms | 2019 |
Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.
Topics: A549 Cells; Antiviral Agents; Enzyme Inhibitors; HEK293 Cells; HeLa Cells; Host-Pathogen Interactions; Humans; Influenza A Virus, H1N1 Subtype; Interferon-alpha; Janus Kinases; Protein Binding; Protein Stability; Proteolysis; Signal Transduction; Suppressor of Cytokine Signaling 1 Protein; Thiophenes; Time Factors; Ubiquitin-Specific Peptidase 7; Ubiquitination; Vesiculovirus | 2020 |
USP7 is a novel Deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis.
Topics: Apoptosis; Cell Cycle Proteins; Chromosomes; Chromosomes, Human; Docetaxel; Drug Resistance, Neoplasm; G2 Phase Cell Cycle Checkpoints; HEK293 Cells; Humans; M Phase Cell Cycle Checkpoints; Male; Mitosis; Nasopharyngeal Neoplasms; Polo-Like Kinase 1; Prostatic Neoplasms; Protease Inhibitors; Protein Serine-Threonine Kinases; Protein Stability; Proto-Oncogene Proteins; Signal Transduction; Thiophenes; Transfection; Ubiquitin-Specific Peptidase 7 | 2019 |
The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.
Topics: Apoptosis; Carcinogenesis; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Maf Transcription Factors, Large; MafB Transcription Factor; Male; Multiple Myeloma; Polyubiquitin; Progression-Free Survival; Proteolysis; Proto-Oncogene Proteins c-maf; Thiophenes; Ubiquitin-Specific Peptidase 7; Ubiquitination | 2020 |
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.
Topics: Animals; Apoptosis; Cell Survival; Cellular Senescence; Doxorubicin; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Mice; Proto-Oncogene Proteins c-mdm2; RNA Interference; Signal Transduction; Thiophenes; Transfection; Tumor Suppressor Protein p53; Ubiquitin-Specific Peptidase 7; Ubiquitination | 2020 |
USP7 inhibition inhibits proliferation and induces megakaryocytic differentiation in MDS cells by upregulating gelsolin.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line; Enzyme Induction; Gelsolin; Heterografts; Humans; Megakaryocytes; Mice; Mice, Inbred NOD; Myelodysplastic Syndromes; Neoplasms, Experimental; Protease Inhibitors; Risk; Thiophenes; Thrombopoiesis; Transcriptome; Ubiquitin-Specific Peptidase 7; Up-Regulation | 2020 |
[Expression of ubiquitin-specific protease 7 in lung tissue of preterm rats after hyperoxia exposure].
Topics: Animals; Animals, Newborn; Hyperoxia; Lung; Random Allocation; Rats; Rats, Wistar; Thiophenes; Ubiquitin-Specific Peptidase 7; Ubiquitin-Specific Proteases; Wnt Signaling Pathway | 2020 |
Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors.
Topics: Cell Line, Tumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Humans; Melanoma; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins B-raf; Thiophenes; Ubiquitin-Specific Peptidase 7; Ubiquitins | 2022 |