thiophenes has been researched along with oxadiazoles in 123 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.81) | 18.7374 |
| 1990's | 4 (3.25) | 18.2507 |
| 2000's | 36 (29.27) | 29.6817 |
| 2010's | 68 (55.28) | 24.3611 |
| 2020's | 14 (11.38) | 2.80 |
| Authors | Studies |
|---|---|
| Belousov, IuB; Parfenov, AS; Savenkov, MP; Savenkov, PM; Sidel'man, AA | 1 |
| AboulWafa, OM; el-Metwalli, MA | 1 |
| Aboul Wafa, OM; Berto, FA | 1 |
| Dawson, GR; Iversen, SD | 1 |
| Kobayashi, S; Muramatsu, N; Toyo'oka, T; Yamaguchi, K | 1 |
| Barreiro, EJ; Noël, F; Silva, CL | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Iida, H; Inoue, N; Ishida, H; Ishikawa, Y; Yuan, Z | 1 |
| Inagaki, K; Iwamura, H; Komatsu, N; Naka, Y; Oda, T; Shinkai, H | 1 |
| Bolick, DT; Clemens, JJ; Davis, MD; Ferger, N; Hatley, ME; Hedrick, CC; Kim, KW; Lynch, KR; Macdonald, TL; Srinivasan, S; Tsao, PS; Whetzel, A | 1 |
| Karliner, JS | 1 |
| Gonzalez-Cabrera, PJ; Hla, T; Jo, E; Osborne, DA; Parrill, AL; Rosen, H; Sanna, MG; Thangada, S; Tigyi, G | 1 |
| Cai, SX; Crogan-Grundy, C; Drewe, J; Kasibhatla, S; Kemnitzer, W; Kuemmerle, J; Ollis-Mason, K; Qiu, L; Tseng, B; Zhang, HZ | 1 |
| Abe, M; Brinkmann, V; Coates, PT; Colvin, BL; De Creus, A; Lan, YY; Thomson, AW | 1 |
| Cahalan, MD; Jo, E; Matheu, MP; Parker, I; Rosen, H; Sanna, MG; Wang, SK; Wei, SH; Wong, CH | 1 |
| Alfonso, C; McHeyzer-Williams, MG; Rosen, H | 1 |
| Awad, AS; Foss, FW; Huang, L; Li, L; Lynch, KR; Macdonald, TL; Okusa, MD; Ye, H | 1 |
| Cho, C; Igarashi, S; Lai, LW; Lien, YH; Yong, KC | 1 |
| Bruns, CJ; Graeb, C; Guba, M; Heeschen, C; Ischenko, I; Jauch, KW; Joka, M; Papyan, A; Schmid, G; Schrepfer, S | 1 |
| Gonzalez-Cabrera, PJ; Hla, T; Rosen, H | 1 |
| Chiba, K; Kataoka, H; Maeda, Y; Matsuyuki, H; Shimano, K; Sugahara, K | 1 |
| Igarashi, S; Lai, LW; Lien, YH; Yong, KC | 1 |
| Bassilana, F; Cortes-Cros, M; Craveiro, LM; Dev, KK; Guerini, D; Mullershausen, F; Osinde, M; Schwab, ME; Seuwen, K; Shin, Y; Sivasankaran, R; Thallmair, M; Wishart, WL | 1 |
| Al-Bayati, RH; Aouad, M; Rezki, N; Sharba, AH | 1 |
| Brinkmann, V; Chun, J; Ip, PC; Potts, EM; Salomone, S; Tyndall, S; Waeber, C | 1 |
| Gottlieb, RA; Rosen, H; Sanna, MG; Tsukada, YT | 1 |
| Aurbach, D; Demadrille, R; Fisyuk, A; Levi, MD; Pomerantz, Z; Pron, A; Salitra, G; Zaban, A | 1 |
| Brown, JH; Chun, J; Means, CK; Miyamoto, S | 1 |
| Huwiler, A; Pfeilschifter, J | 1 |
| Chwalla, I; Krump-Konvalinkova, V; Siess, W | 1 |
| Gollmann, G; Heufler, C; Konwalinka, G; Mueller, H; Neuwirt, H; Romani, N; Tiefenthaler, M; Tripp, CH | 1 |
| Altamura, S; Branca, D; Cecchetti, O; Ferrigno, F; Jones, P; Muraglia, E; Orsale, MV; Palumbi, MC; Rowley, M; Scarpelli, R; Steinkühler, C | 1 |
| Bras, M; van Der Lee, MM; van Koppen, CJ; Zaman, GJ | 1 |
| Bäumer, W; Kietzmann, M; Kleuser, B; Lüth, A; Mischke, R; Reines, I; Tschernig, T | 1 |
| Goetzl, EJ; Huang, MC; Karliner, JS; Li, H; Malhotra, D; Mann, MJ; Vessey, DA; Yeh, CC; Zhu, BQ | 1 |
| Aumercier, M; Baulard, AR; Bifani, P; Carette, X; Delcroix, G; Déprez, B; Déprez-Poulain, R; Desroses, M; Dirié, B; Frénois, F; Leroux, F; Locht, C; Mathys, V; Singhal, A; Villeret, V; Willand, N; Willery, E | 1 |
| Bonz, A; Burkard, N; Ertl, G; Frantz, S; Hofmann, U; Ritter, O; Thoma, A; Vogt, C | 1 |
| Goforth, PB; Lynch, KR; Macdonald, TL; Mba, MU; Milstien, S; Satin, LS; Selley, DE; Sim-Selley, LJ; Spiegel, S; Welch, SP | 1 |
| Buller, HR; Esmon, CT; Niers, TM; Richel, DJ; Spek, CA; Tigchelaar, W; Van Noorden, CJ; Van Sluis, GL | 1 |
| Bae, H; Dukala, D; Jung, CG; Kakazu, R; Kim, HJ; Soliven, B; Wollmann, R | 1 |
| Chiang, ET; Dudek, SM; Evenoski, CL; Garcia, JG; Husain, A; Jacobson, JR; Mathew, B; Mirzapoiazova, T; Moitra, J; Moreno-Vinasco, L; Natarajan, V; Nunez, L; Sammani, S; Singleton, PA; Sun, X; Wang, T | 1 |
| Colonna, J; Crousillac, S; Dewey, JS; Gleason, E; McMains, E | 1 |
| Knudsen, E; Maghazachi, AA; Rolin, J; Sand, KL | 1 |
| Hasegawa, Y; Rolland, W; Sozen, T; Suzuki, H; Zhang, JH | 1 |
| Brooks, SF; Chun, J; Fontaine, BA; Luster, AD; Shea, BS; Tager, AM | 1 |
| Bajwa, A; Dondeti, KR; Haase, VH; Huang, L; Jo, SK; Lynch, KR; Macdonald, TL; Okusa, MD; Rosin, DL; Ye, H | 1 |
| Brown, KM; Chen, SW; D'Agati, VD; Kim, M; Lee, HT; Park, SW | 1 |
| Chiba, K; Maeda, Y; Sato, N; Seki, N; Sugahara, K | 1 |
| Chi, XX; Nicol, GD | 1 |
| Armstrong, M; Holman, TR; Hoobler, E; Jadhav, A; Jameson, JB; Kenyon, V; Leister, W; Maloney, DJ; Rai, G; Schultz, L; Simeonov, A | 1 |
| Li, C; Li, L; Lin, M; Liu, X; Yang, L; You, H; Zheng, S | 1 |
| Chen, Z; Doyle, T; Finley, A; Salvemini, D | 1 |
| Belavagi, N; Khazi, IA; Panchamukhi, SI; Rabinal, MH | 1 |
| Stamer, WD; Sumida, GM | 1 |
| Awad, AS; Bolton, WK; Huang, L; Khutsishvili, K; Lynch, KR; Okusa, MD; Rouse, MD | 1 |
| Giegold, O; Huwiler, A; Juan, MH; Maltusch, K; Pfeilschifter, JM; Quintini, G; Radeke, HH; Richter, C; Schröder, M | 1 |
| Heytens, E; Oktay, K; Soleimani, R | 1 |
| Garcia, JG; Huang, Y; Husain, AN; Lussier, YA; Mathew, B; Moreno-Vinasco, L; Park, KS; Sammani, S; Vigneswaran, WT; Wang, T; Zaidi, SR; Zhou, T | 1 |
| Carroll, DL; Coffin, RC; Li, Y; Macneill, CM; Nie, W; Noftle, RE | 1 |
| Baulard, A; Bonnel, D; Deprez, B; Hamm, G; Legouffe, R; Stauber, J; Willand, N | 1 |
| Anderson, RA; Bundhoo, SS; Dada, J; Halcox, JP; Harris, R; James, PE; Lang, D; Sagan, E | 1 |
| Adyshev, DM; Dudek, SM; Elangovan, VR; Garcia, JG; Moldobaeva, NK | 1 |
| Dev, KK; Sheridan, GK | 1 |
| Abe, Y; Asano, M; Doi, H; Inoue, R; Kagari, T; Kaneko, R; Kawase, Y; Kimura, T; Mizuno, Y; Nagasaki, M; Nakamura, T; Nara, F; Nishi, T; Oguchi-Oshima, K; Sekiguchi, Y; Shimozato, T; Tamaki, K; Tomisato, W; Watanabe, N; Yuita, H | 1 |
| Asano, M; Doi-Komuro, H; Inoue, R; Kagari, T; Kamiyama, E; Kaneko, R; Kawase, Y; Mizuno, Y; Nagasaki, M; Nakai, D; Nakamura, T; Nara, F; Nishi, T; Oguchi-Oshima, K; Sekiguchi, Y; Shimozato, T; Tamaki, K; Tomisato, W; Urasaki-Kaneno, Y; Yabe, Y; Yuita, H | 1 |
| Bek, T; Kringelholt, S; Simonsen, U | 1 |
| Adamson, RH; Clark, JF; Curry, FE | 1 |
| Esmon, CT; Kager, LM; Meijers, JC; Roelofs, JJ; van der Poll, T; van't Veer, C; Wiersinga, WJ; Zeerleder, SS | 1 |
| Dumin, JA; Loureiro, RM; McKee, TD; Tate, B; Zarayskiy, V | 1 |
| Akhade, AS; Qadri, A; Sharma, N | 1 |
| Bauer, Y; Bolli, MH; Gatfield, J; Killer, N; Menyhart, K; Nayler, O; Renault, B; Sobel, K; Steiner, B; Studer, R | 1 |
| Bornhäuser, M; Brand, M; Ehninger, G; Lambert, K; Meyer, C; Shayegi, N | 1 |
| Chen, X; Fan, Y; Hao, W; Hou, X; Jin, Y; Liu, F; Ma, A; Pang, T; Song, Z; Wang, W; Wang, Y; Zhang, P | 1 |
| Bäumer, W; Kietzmann, M; Schaper, K | 1 |
| Dong, J; Gong, J; Gu, L; Li, J; Li, Y; Wang, H; Wu, G; Zhang, L; Zhao, J; Zhu, W; Zuo, L | 1 |
| Absalom, AR; Bouma, HR; Buikema, H; Epema, AH; Henning, RH; Houwertjes, MC; Mungroop, HE; Samarska, IV | 1 |
| Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A | 1 |
| Murakami, M; Saito, T; Tabata, Y | 1 |
| Al-Jarallah, A; Chen, X; González, L; Trigatti, BL | 1 |
| Abraham, SN; Ang, WXG; Chan, EW; Gunn, MD; Huang, MN; Kunder, CA; St John, AL | 1 |
| Aalkjaer, C; Bek, T; El-Galaly, A; Kringelholt, SK; Misfeldt, MW | 1 |
| Gokden, N; Mayeux, PR; Patil, NK; Sims, CR; Wang, Z | 1 |
| Ahmadiani, A; Dargahi, L; Khallaghi, B; Safarian, F | 1 |
| Dong, J; Gong, J; Gu, L; Li, J; Li, Y; Sun, J; Wang, H; Zhang, T; Zhao, J; Zhu, W; Zuo, L | 1 |
| Bai, HY; Chisaka, T; Horiuchi, M; Iwanami, J; Kan-no, H; Kukida, M; Mogi, M; Nakaoka, H; Shan, BS; Tsukuda, K; Wang, XL | 1 |
| Dai, L; Huang, P; Jin, X; Lan, F; Liu, T; Lu, X; Luo, X; Ni, Q; Yin, H; Yuan, B | 1 |
| Ahmadiani, A; Asle-Rousta, M; Dargahi, L; Kolahdooz, Z; Nasoohi, S | 1 |
| Dong, CZ; Guan, S; Li, J; Xu, ZY; Zhang, L | 1 |
| Ke, L; Li, J; Li, N; Li, W; Tong, Z; Wu, C; Zou, L | 1 |
| Ichijo, M; Ishibashi, S; Li, F; Miki, K; Mizusawa, H; Yokota, T; Yui, D | 1 |
| Dukala, DE; Soliven, B | 1 |
| Kim, YH; Tabata, Y | 1 |
| Alvarez, K; Barral, K; Benmansour, F; Canard, B; de Lamballerie, X; Eydoux, C; Guillemot, JC; Querat, G | 1 |
| Dev, KK; Mir, AK; O'Sullivan, C; Schubart, A | 1 |
| Klebe, D; Krafft, PR; LeGrand, J; Lekic, T; Rolland, WB; Weldon, AJ; Xu, L; Zhang, JH | 1 |
| Attiori Essis, S; Chagniel, L; Cyr, M; Germain, M; Massicotte, G; St-Cyr Giguère, F | 1 |
| Basoglu, A; Dirkmann, S; Fröhlich, R; Müller, K; Nowottnik, D; Prinz, H; Tentrop, J; Vortherms, S; Zahedi Golpayegani, N | 1 |
| Burkard, N; Flemming, S; Germer, CT; Meir, M; Schick, MA; Schlegel, N | 1 |
| Haniuda, M; Hosokawa, Y; Hyodo, T; Karnan, S; Konishi, H; Ota, A; Tsuzuki, S; Wahiduzzaman, M; Yamaji, M | 1 |
| Guo, F; Zhou, Y | 1 |
| Donahue, RR; Doolen, S; Grachen, CM; Iannitti, T; Shaw, BC; Taylor, BK | 1 |
| Isaji, S; Ito, T; Kato, H; Kuriyama, N; Matsuda, A; Mizuno, S; Sakurai, H; Usui, M | 1 |
| Ichijo, M; Ishibashi, S; Iwasawa, E; Li, F; Miki, K; Suzuki, M; Yokota, T | 1 |
| Chen, W; Ding, D; Fan, M; Li, Y; Song, X; Sun, M; Yang, R; Yu, L; Zhang, K | 1 |
| He, D; Jian, W; Shang, J; Wen, L | 1 |
| Blundell, R; Butler, MS; Cooper, MA; Fraser, JA; Furlong, E; Kappler, U; Kobe, B; Kummari, LK; Nouwens, A; Robertson, AAB; Silva, AB | 1 |
| Czubowicz, K; Strosznajder, RP; Wencel, PL; Wójtowicz, S | 1 |
| Chen, Z; Doyle, TM; Durante, M; Salvemini, D | 1 |
| Fujiwara, Y; Jo, JI; Saito, Y; Tabata, Y; Tanaka, R | 1 |
| Bedoya, CAF; Buzbee, M; Harden, A; Marmonti, E; Morrell, MG; Savage, H; Schadler, K; Zhang, A | 1 |
| Flynn, B; Hua, Y; Huang, L; Kaye, D; Liew, D; Magaye, RR; Reid, C; Savira, F; Wang, BH; Xiong, X | 1 |
| Pei, FN; Tang, J; Wang, ZC; Wei, B; Yang, CG; Yang, F; Yang, S; Yang, T; Yu, LF | 1 |
| Balletta, S; Bruno, A; Bullitta, S; Buttari, F; Caioli, S; Centonze, D; De Vito, F; Dolcetti, E; Fresegna, D; Gentile, A; Guadalupi, L; Mandolesi, G; Musella, A; Nencini, M; Rizzo, FR; Sanna, K; Stampanoni Bassi, M; Vanni, V; Vitiello, L | 1 |
| Chai, Y; Huang, X; Jiang, Z; Miao, Y; Sun, L; Wang, H; Wang, X; Wu, Z; Yang, T; Yu, Q; Yuan, Z; Zhang, L | 1 |
| Li, J; Liu, Y; Ma, Z; Sun, Z; Wu, Y; Zhu, Y | 1 |
| Jaswal, S; Kumar, S; Monga, V; Rulhania, S | 1 |
| Chai, Y; Heng, C; Huang, X; Jiang, Z; Liu, B; Miao, Y; Sun, L; Wang, X; Wu, Z; Yang, H; Yang, T; Yu, Q; Yuan, Z; Zhang, L; Zhou, Y | 1 |
| Amin, S; Battu, MB; Berg, A; Chen, YC; Chirasani, VR; Cho, SH; Dinavahi, SS; Dokholyan, NV; Feng, Q; Gowda, R; Hafenstein, SL; He, P; Kirchhausen, T; LaPenna, KB; Ramisetti, S; Robertson, GP; Sharma, AK; Xia, X | 1 |
| Hu, C; Qi, D; Shang, Z; Xu, Y; Yang, Q; Zhang, D; Zhang, G; Zhang, X | 1 |
| Hussar, DA | 1 |
| Garrett, TJ; Giancotti, LA; Harada, CM; Harmon, TA; Kolar, G; Lauro, F; Salvemini, D | 1 |
| Lamerand, SR; Mork, BE; Sheets, PL; Taylor, BK; Zhou, S | 1 |
| Busra Azizoglu, Z; Canatan, H; Eken, A; Zehra Okus, F | 1 |
3 review(s) available for thiophenes and oxadiazoles
| Article | Year |
|---|---|
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Topics: Animals; Fingolimod Hydrochloride; Humans; Lysophospholipids; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Pyrazoles; Pyridines; Receptors, Lysosphingolipid; Sphingosine; Sulfhydryl Compounds; Thiazolidines; Thiophenes | 2008 |
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.
Topics: Acetazolamide; Animals; Antineoplastic Agents; Antioxidants; Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Indoles; Isatin; Molecular Docking Simulation; Organoselenium Compounds; Oxadiazoles; Protein Binding; Protein Isoforms; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Thiazines; Thiophenes; Urea | 2021 |
1 trial(s) available for thiophenes and oxadiazoles
| Article | Year |
|---|---|
[Pharmacotherapy of peripheral arteriosclerosis].
Topics: Aged; Arteriosclerosis; Arteriosclerosis Obliterans; Azepines; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Leg; Male; Microcirculation; Middle Aged; Oxadiazoles; Pentoxifylline; Plethysmography, Impedance; Pyridinolcarbamate; Thiophenes; Vasodilator Agents | 1978 |
119 other study(ies) available for thiophenes and oxadiazoles
| Article | Year |
|---|---|
Benzo[b]thiophenes, II: Novel benzo[b]thienylhydrazine and 1,3,4-oxadiazole derivatives as potential antidepressant agents.
Topics: Animals; Antidepressive Agents; In Vitro Techniques; Male; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Oxadiazoles; Proteins; Rats; Thiophenes | 1992 |
Benzo[b]thiophenes, Part I: Synthesis and antimicrobial activity of benzo[b]thienyl-1,3,4-oxadiazole, -1,2,4-triazoline, and -thiazoline derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida albicans; Microbial Sensitivity Tests; Oxadiazoles; Thiazoles; Thiophenes; Triazoles | 1992 |
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory.
Topics: Animals; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Conditioning, Classical; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Memory; Mice; Oxadiazoles; Pain Threshold; Parasympathomimetics; Physostigmine; Piperidines; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 1993 |
High-performance liquid chromatographic determination of erdosteine and its optical active metabolite utilizing a fluorescent chiral tagging reagent, R-(-)-4-(N,N-dimethylamiosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2 ,1,3-benzoxadiazole.
Topics: Animals; Chromatography, High Pressure Liquid; Fluorescent Dyes; Oxadiazoles; Rats; Spectrometry, Fluorescence; Stereoisomerism; Sulfonamides; Thioglycolates; Thiophenes | 1998 |
Cyclic GMP-dependent vasodilatory properties of LASSBio 294 in rat aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Hydrazones; In Vitro Techniques; Indomethacin; Male; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Thiophenes; Vasoconstriction; Vasodilator Agents | 2002 |
Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.
Topics: Alkaloids; Amylases; Animals; Azepines; Benzoates; Benzylamines; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Chelating Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gallic Acid; Genotype; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Mice, Knockout; Molsidomine; Muscarinic Agonists; Myosin-Light-Chain Kinase; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Parotid Gland; Penicillamine; Phosphodiesterase Inhibitors; Pilocarpine; Protein Kinase Inhibitors; Pyrroles; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Type C Phospholipases | 2003 |
Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities.
Topics: Animals; Biomimetic Materials; Blood Cell Count; Busulfan; Cell Differentiation; Cell Division; Cell Line, Tumor; Colony-Forming Units Assay; DNA-Binding Proteins; Erythropoietin; Humans; Interleukin-11; Janus Kinase 2; Male; Mice; Mice, Inbred BALB C; Milk Proteins; Oxadiazoles; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Recombinant Proteins; Signal Transduction; STAT5 Transcription Factor; Thiophenes; Thrombopoiesis; Thrombopoietin; Trans-Activators; Tyrosine | 2004 |
Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.
Topics: Animals; Aorta; Cell Adhesion; Cells, Cultured; Chemokines; E-Selectin; Endothelium, Vascular; Intercellular Adhesion Molecule-1; Lysophospholipids; Mice; Mice, Inbred C57BL; Monocytes; Oxadiazoles; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1; Vasculitis | 2005 |
Off the shelf but not mass produced.
Topics: Drug Evaluation, Preclinical; Lysophospholipids; Oxadiazoles; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Thiophenes | 2005 |
S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.
Topics: Animals; Binding Sites; Cell Line; Cell Membrane; Cricetinae; Drug Evaluation, Preclinical; Enzyme Activation; Humans; Ligands; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Molecular; Molecular Probes; Mutation; Oxadiazoles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rac GTP-Binding Proteins; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Thiophenes | 2005 |
Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enzyme Activation; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Mice; Oxadiazoles; Perilipin-3; Pregnancy Proteins; Receptor, IGF Type 2; Structure-Activity Relationship; Thiophenes; Vesicular Transport Proteins | 2005 |
The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Adhesion Molecules; Cell Differentiation; Dendritic Cells; DNA Primers; Fingolimod Hydrochloride; Immunosuppressive Agents; Lymphocyte Depletion; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Oxadiazoles; Polymerase Chain Reaction; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes; Thiophenes | 2005 |
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.
Topics: Animals; Cell Migration Inhibition; Cell Movement; Cells, Cultured; Lymph Nodes; Lymphatic Vessels; Lysophospholipids; Mice; Mice, Inbred BALB C; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocyte Subsets; Thiophenes | 2005 |
CD69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Cell Differentiation; Chemotaxis, Leukocyte; Down-Regulation; Female; Flow Cytometry; Lectins, C-Type; Lymph Nodes; Lymphocytes; Mice; Mice, Inbred C57BL; Oxadiazoles; Receptors, Lysosphingolipid; Thiophenes; Thymus Gland | 2006 |
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.
Topics: Animals; Capillary Permeability; Creatinine; Fingolimod Hydrochloride; Kidney; Leukocytes; Lymphocyte Count; Mice; Mice, Inbred C57BL; Oxadiazoles; Peroxidase; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; T-Lymphocytes; Thiophenes | 2006 |
S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure.
Topics: Acute Kidney Injury; Animals; Cell Adhesion Molecules; Down-Regulation; Ischemia; Kidney; Leukocyte Count; Male; Mice; Oxadiazoles; Receptors, Lysosphingolipid; Reperfusion Injury; RNA, Messenger; Thiophenes; Tumor Necrosis Factor-alpha | 2006 |
The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.
Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Cell Division; Cells, Cultured; Coculture Techniques; Collagen; Drug Combinations; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Laminin; Mice; Mice, Inbred C57BL; Muscle, Smooth; Neoplasm Transplantation; Neovascularization, Pathologic; Neutralization Tests; Oxadiazoles; Propylene Glycols; Proteoglycans; Receptors, CXCR4; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Transcriptional Activation; Transplantation, Isogeneic; Umbilical Veins; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2007 |
Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
Topics: Cells, Cultured; Chloroquine; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Lysophospholipids; Oxadiazoles; Propylene Glycols; Protein Transport; Proteomics; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Ubiquitin | 2007 |
Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Movement; Cells, Cultured; Dendritic Cells; Dose-Response Relationship, Drug; Down-Regulation; Endocytosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Knockout; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiophenes | 2007 |
A sphingosine-1-phosphate type 1 receptor agonist inhibits the early T-cell transient following renal ischemia-reperfusion injury.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Movement; Chemokines; Fluorescent Antibody Technique; Kidney; Kidney Pelvis; Lymphopenia; Male; Mice; Oxadiazoles; Receptors, Lysosphingolipid; Reperfusion Injury; Thiophenes | 2007 |
Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Astrocytes; beta-Alanine; Calcium Signaling; Cell Movement; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Embryo, Mammalian; Fingolimod Hydrochloride; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Immunosuppressive Agents; Inositol Phosphates; Organ Culture Techniques; Oxadiazoles; Propylene Glycols; Rats; Receptors, Lysosphingolipid; Sphingosine; Thiophenes | 2007 |
Synthesis of oxadiazoles, thiadiazoles and triazoles derived from benzo[b]thiophene.
Topics: Oxadiazoles; Thiadiazoles; Thiophenes; Triazoles | 2005 |
Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.
Topics: Animals; Cerebral Arteries; Dose-Response Relationship, Drug; Fingolimod Hydrochloride; In Vitro Techniques; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Propylene Glycols; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Vasoconstriction | 2008 |
S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias.
Topics: Aniline Compounds; Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Models, Biological; Molecular Structure; Myocardial Infarction; Myocardial Reperfusion Injury; Oxadiazoles; Perfusion; Phenyl Ethers; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sodium-Calcium Exchanger; Thiophenes; Time Factors; Ventricular Function, Left | 2007 |
UV-Vis-NIR spectroelectrochemical and in situ conductance studies of unusual stability of n- and p-doped poly(dimethyldioctylquaterthiophene-alt-oxadiazole) under high cathodic and anodic polarizations.
Topics: Electric Conductivity; Electrochemistry; Electrodes; Molecular Structure; Oxadiazoles; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Spectroscopy, Near-Infrared; Surface Properties; Thiophenes | 2008 |
S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses.
Topics: Animals; beta-Cyclodextrins; Cyclic AMP; Enzyme Activation; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Isoproterenol; Lysophospholipids; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Myocardial Contraction; Myocytes, Cardiac; Oxadiazoles; Pertussis Toxin; Protein Transport; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; RNA, Messenger; Sphingosine; Thiophenes | 2008 |
FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression.
Topics: Actins; Cell Adhesion Molecules; Cell Membrane; Cell Movement; Cells, Cultured; Endothelium, Vascular; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lysophospholipids; Neovascularization, Physiologic; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Wound Healing | 2008 |
Sphingosine-1-phosphate receptor type-1 agonism impairs blood dendritic cell chemotaxis and skin dendritic cell migration to lymph nodes under inflammatory conditions.
Topics: Animals; Blood Cells; CD18 Antigens; Cell Migration Inhibition; Cells, Cultured; Chemotaxis; Dendritic Cells; Humans; Immunophenotyping; Inflammation; Langerhans Cells; Mice; Mice, Inbred BALB C; Oxadiazoles; Receptors, Lysosphingolipid; Skin; Thiophenes | 2008 |
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.
Topics: Combinatorial Chemistry Techniques; Drug Design; HCT116 Cells; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiophenes | 2008 |
beta-Arrestin recruitment assay for the identification of agonists of the sphingosine 1-phosphate receptor EDG1.
Topics: Animals; Arrestins; beta-Alanine; beta-Arrestins; Biological Assay; Cell Differentiation; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Proteins; Humans; Oxadiazoles; Phosphorylation; Protein Binding; Receptors, Interleukin-8B; Receptors, Lysosphingolipid; Signal Transduction; Small Molecule Libraries; Sphingosine-1-Phosphate Receptors; Thiophenes; Time Factors | 2008 |
Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.
Topics: Administration, Topical; Animals; Cell Movement; Dendritic Cells; Dermatitis, Allergic Contact; Female; Fingolimod Hydrochloride; Histocompatibility Antigens Class II; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred BALB C; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Skin; Sphingosine; Thiophenes; Toluene 2,4-Diisocyanate | 2009 |
Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction.
Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocytes, Cardiac; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; RNA, Messenger; Signal Transduction; Sphingolipids; Thiophenes; Ventricular Remodeling | 2009 |
Synthetic EthR inhibitors boost antituberculous activity of ethionamide.
Topics: Animals; Antitubercular Agents; Binding Sites; DNA-Binding Proteins; Drug Synergism; Ethionamide; Hydrogen Bonding; Ligands; Mice; Models, Molecular; Oxadiazoles; Protein Conformation; Repressor Proteins; Thiophenes; Tuberculosis | 2009 |
Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Death; Cells, Cultured; ErbB Receptors; Fingolimod Hydrochloride; Humans; Lysophospholipids; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxadiazoles; Perfusion; Propylene Glycols; Proto-Oncogene Proteins c-akt; Rats; Receptors, Lysosphingolipid; Recovery of Function; Signal Transduction; Sphingosine; Thiophenes; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2009 |
Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS.
Topics: Animals; Animals, Newborn; Binding, Competitive; Cannabinoids; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Lysophospholipids; Neurons; Oxadiazoles; Patch-Clamp Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Receptors, Neurotransmitter; Signal Transduction; Sphingosine; Sulfur Radioisotopes; Synaptic Transmission; Thiophenes | 2009 |
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement.
Topics: Animals; Antibodies, Monoclonal; Anticoagulants; Antigens, CD; Cadherins; Endothelium, Vascular; Evans Blue; Female; Melanoma, Experimental; Mice; Models, Biological; Neoplasms; Oxadiazoles; Protein C; Receptors, Lysosphingolipid; Signal Transduction; Thiophenes | 2009 |
Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy.
Topics: Animals; Autoimmunity; Blood-Nerve Barrier; Blotting, Western; Cell Culture Techniques; Cell Proliferation; Cell Survival; Cytokines; Electrophysiology; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Mice; Mice, Inbred NOD; Mice, Transgenic; Oxadiazoles; Polymerase Chain Reaction; Polyneuropathies; Propylene Glycols; Schwann Cells; Severity of Illness Index; Sphingosine; Spleen; Thiophenes | 2009 |
Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung.
Topics: Acute Lung Injury; Animals; Blood-Air Barrier; Body Fluids; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Inverse Agonism; Gene Deletion; Gene Silencing; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxadiazoles; Receptors, Lysosphingolipid; Thiophenes | 2010 |
Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells.
Topics: Amacrine Cells; Animals; Calcium; Calcium Signaling; Cells, Cultured; Chick Embryo; Estrenes; Heparin; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Lanthanoid Series Elements; Lysophospholipids; Membrane Potentials; Models, Biological; Oxadiazoles; Patch-Clamp Techniques; Pertussis Toxin; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Retina; Sphingosine; Tetraethylammonium; Thiophenes; Type C Phospholipases | 2009 |
FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release.
Topics: Chemokines; Cytokines; Cytotoxicity, Immunologic; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Fingolimod Hydrochloride; Flow Cytometry; Humans; Immunoblotting; Immunosuppressive Agents; K562 Cells; Killer Cells, Natural; Lysophospholipids; Oxadiazoles; Propylene Glycols; Sphingosine; Thiophenes; Up-Regulation | 2010 |
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Disease Models, Animal; Drug Administration Schedule; Fingolimod Hydrochloride; Immunosuppressive Agents; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Nerve Degeneration; Neuroprotective Agents; Oxadiazoles; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Stroke; Thiophenes; Treatment Outcome | 2010 |
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.
Topics: Animals; beta-Alanine; Bleomycin; Blood Coagulation; Endothelial Cells; Fibrosis; Fingolimod Hydrochloride; Humans; Lung Injury; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Pneumonia; Propylene Glycols; Pulmonary Alveoli; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Survival Analysis; Thiophenes; Vascular Diseases | 2010 |
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Movement; Disease Models, Animal; Epithelial Cells; Fingolimod Hydrochloride; Homeodomain Proteins; Kidney Tubules, Proximal; Leukocytes; Lipopolysaccharides; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Reperfusion Injury; RNA, Messenger; Signal Transduction; Sphingosine; Thiophenes | 2010 |
Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation.
Topics: Acute Kidney Injury; Animals; Extracellular Signal-Regulated MAP Kinases; Ischemia; Kidney; Liver; Liver Diseases; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Oxadiazoles; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; Reperfusion Injury; Signal Transduction; Sphingosine; Thiophenes | 2010 |
Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.
Topics: Adoptive Transfer; Animals; Bone Marrow; Cell Count; Cell Movement; Fingolimod Hydrochloride; Hypersensitivity, Delayed; Immunization; Lymphoid Tissue; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Ovalbumin; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes; Thiophenes | 2010 |
The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons.
Topics: Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Electrophysiology; Lysophospholipids; Male; Membrane Potentials; Oxadiazoles; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Sphingosine; Thiophenes | 2010 |
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.
Topics: Alkynes; Arachidonate 15-Lipoxygenase; Benzoates; Binding Sites; Esters; Humans; Kinetics; Lipoxygenase Inhibitors; Models, Molecular; Naphthalenes; Oxadiazoles; Reticulocytes; Small Molecule Libraries; Structure-Activity Relationship; Sulfides; Thiophenes | 2010 |
Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility.
Topics: Base Sequence; Cell Movement; Cells, Cultured; Humans; Liver Cirrhosis; Lysophospholipids; Myofibroblasts; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Suramin; Thiophenes | 2011 |
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats.
Topics: Acetophenones; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Hyperalgesia; Lysophospholipids; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Organophosphonates; Oxadiazoles; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Time Factors | 2011 |
Synthesis and optoelectronic properties of symmetrical thiophene based 2,5-disubstiuted 1,3,4-oxadiazoles: highly fluorescent materials for OLED applications.
Topics: Fluorescence; Molecular Structure; Optics and Photonics; Oxadiazoles; Quantum Theory; Spectrometry, Fluorescence; Thiophenes | 2011 |
S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology.
Topics: Animals; Aqueous Humor; Cells, Cultured; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Lysophospholipids; Myosin Light Chains; Oxadiazoles; Phosphorylation; Pyrazoles; Pyridines; Receptors, Lysosphingolipid; Sphingosine; Swine; Thiophenes; Trabecular Meshwork | 2011 |
Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fingolimod Hydrochloride; Kidney; Lymphocytes; Mice; Mice, Inbred C57BL; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); Podocytes; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha | 2011 |
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
Topics: Animals; Bone Marrow Cells; CD8 Antigens; Cell Differentiation; Dendritic Cells; Enzyme Assays; Flow Cytometry; Gene Deletion; Gene Expression Regulation; Indans; Interleukin-12; Interleukin-12 Receptor beta 2 Subunit; Interleukin-12 Subunit p40; Lipopolysaccharides; Lymphocyte Activation; Lysophospholipids; Membrane Proteins; Mice; Oxadiazoles; Phosphotransferases (Alcohol Group Acceptor); RNA, Messenger; Sphingosine; Spleen; Thiophenes; Toll-Like Receptors | 2011 |
Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
Topics: Animals; Apoptosis; Cryopreservation; Female; Fingolimod Hydrochloride; Graft Survival; Humans; Immunohistochemistry; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, SCID; Neovascularization, Physiologic; Ovarian Follicle; Ovary; Oxadiazoles; Propylene Glycols; Sphingosine; Thiophenes; Transplantation, Heterologous | 2011 |
A sphingosine 1-phosphate 1 receptor agonist modulates brain death-induced neurogenic pulmonary injury.
Topics: Animals; Brain Death; Bronchoalveolar Lavage Fluid; Capillary Permeability; Endothelial Cells; Gene Expression; Lung; Lung Injury; Male; Oxadiazoles; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Receptors, CCR2; Receptors, Lysosphingolipid; Thiophenes; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
A soluble high molecular weight copolymer of benzo[1,2-b:4,5-b']dithiophene and benzoxadiazole for efficient organic photovoltaics.
Topics: Electric Power Supplies; Molecular Structure; Molecular Weight; Oxadiazoles; Polymers; Solar Energy; Thiophenes | 2011 |
MALDI imaging techniques dedicated to drug-distribution studies.
Topics: Animals; Benzodiazepines; Mice; Olanzapine; Oxadiazoles; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Thiophenes; Tissue Distribution | 2011 |
Direct vasoactive properties of thienopyridine-derived nitrosothiols.
Topics: Animals; Aorta, Thoracic; Clopidogrel; Glutathione; Guanylate Cyclase; Hydrogen-Ion Concentration; In Vitro Techniques; Luminescent Measurements; Male; Mass Spectrometry; Molecular Structure; Nitro Compounds; Oxadiazoles; Ozone; Piperazines; Prasugrel Hydrochloride; Quinoxalines; Rabbits; S-Nitrosothiols; Sodium Nitrite; Spectrophotometry, Ultraviolet; Thienopyridines; Thiophenes; Ticlopidine; Vasodilation; Vasodilator Agents | 2011 |
Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.
Topics: Actins; Amides; Antigens, CD; Bacterial Proteins; Bacterial Toxins; Cadherins; Cell Membrane; Cells, Cultured; Chelating Agents; Cytoskeletal Proteins; Cytoskeleton; Egtazic Acid; Electric Impedance; Endothelial Cells; Gene Knockdown Techniques; Humans; Imidazoles; Lysophospholipids; Membrane Proteins; Microfilament Proteins; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Protein Kinase C; Pulmonary Artery; Pyridines; Receptors, Lysosphingolipid; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; Sphingosine; Thiophenes | 2011 |
S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Movement; Cerebellum; Chemokine CCL20; Chemokine CCL3; Chemokines; Demyelinating Diseases; Fingolimod Hydrochloride; Gene Expression Regulation; Immunosuppressive Agents; Lysophosphatidylcholines; Myelin Basic Protein; Neurofilament Proteins; Organ Culture Techniques; Oxadiazoles; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes | 2012 |
Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.
Topics: Administration, Oral; Animals; Binding, Competitive; Drug Discovery; Humans; Immune System; Immunosuppressive Agents; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Oxadiazoles; Rats; Receptors, Lysosphingolipid; Structure-Activity Relationship; Thiophenes | 2012 |
Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.
Topics: Administration, Oral; Animals; Chemistry Techniques, Synthetic; Drug Design; Female; Half-Life; Humans; Male; Mice; Oxadiazoles; Rats; Receptors, Lysosphingolipid; Thiophenes | 2012 |
Dorzolamide-induced relaxation of intraocular porcine ciliary arteries in vitro depends on nitric oxide and the vascular endothelium.
Topics: Acetazolamide; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Ciliary Arteries; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen-Ion Concentration; Isometric Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Sulfonamides; Swine; Thiazines; Thiophenes; Vasodilation; Vasodilator Agents | 2012 |
Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels.
Topics: Albumins; Animals; Capillary Permeability; Endothelium, Vascular; Erythrocytes; Lactalbumin; Lysophospholipids; Male; Mesentery; Oxadiazoles; Paracrine Communication; Pressure; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Time Factors; Venules | 2012 |
Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis).
Topics: Animals; Antibodies, Monoclonal; Bacterial Load; Blood Coagulation; Burkholderia pseudomallei; Cytokines; Cytoprotection; Disease Models, Animal; Female; Inflammation; Inflammation Mediators; Liver; Lung; Lysophospholipids; Melioidosis; Mice; Mice, Inbred C57BL; Oxadiazoles; Protein C; Receptor, PAR-1; Sepsis; Signal Transduction; Sphingosine; Thiophenes; Time Factors | 2013 |
An improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates.
Topics: Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Azepines; Cell Line; Enzyme Inhibitors; Humans; Oxadiazoles; Receptors, Notch; Solid Phase Extraction; Substrate Specificity; Sulfonamides; Thiophenes | 2013 |
Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells.
Topics: Calcium; Fingolimod Hydrochloride; Flagellin; Gene Expression Regulation; Humans; Interleukin-2; Interleukin-8; Jurkat Cells; Lipopeptides; Lymphocyte Activation; Lysophospholipids; Molecular Mimicry; Oxadiazoles; Propylene Glycols; Receptors, Antigen, T-Cell; Serum; Signal Transduction; Sphingosine; T-Lymphocytes; Thiophenes; Toll-Like Receptors; U937 Cells | 2013 |
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling.
Topics: Actins; Animals; CHO Cells; Cricetinae; Cricetulus; Down-Regulation; Extracellular Matrix; Humans; Lung; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myofibroblasts; Organophosphates; Oxadiazoles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Fibrosis; Receptors, Lysosphingolipid; Signal Transduction; Smad2 Protein; Smad3 Protein; Sphingosine; Thiazoles; Thiophenes; Transforming Growth Factor beta1 | 2013 |
CXCR4 blockade and sphingosine-1-phosphate activation facilitate engraftment of haematopoietic stem and progenitor cells in a non-myeloablative transplant model.
Topics: Animal Experimentation; Animals; Benzylamines; Cyclams; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Heterocyclic Compounds; Lysophospholipids; Oxadiazoles; Receptors, CXCR4; Signal Transduction; Sphingosine; Thiophenes; Transplantation Chimera; Transplantation, Homologous; Zebrafish | 2014 |
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Drug Screening Assays, Antitumor; Drug Synergism; Hedgehog Proteins; Humans; Jurkat Cells; MAP Kinase Signaling System; Oxadiazoles; Phosphorylcholine; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Pyridines; Thiophenes; Transcription Factors; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2014 |
Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells.
Topics: Androstadienes; Animals; Bone Marrow Cells; Cells, Cultured; Dendritic Cells; Enzyme Inhibitors; Gene Expression; Immunoblotting; Interleukin-12; Interleukin-23; Interleukin-27; Lipopolysaccharides; Lysophospholipids; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyrazoles; Pyridines; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Thiophenes; Wortmannin | 2014 |
Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice.
Topics: Administration, Oral; Animals; Cell Movement; Colon; Crohn Disease; Cytokines; Disease Progression; Humans; Interleukin-10; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Oxadiazoles; Peroxidase; Receptors, Lysosphingolipid; Serum Amyloid A Protein; STAT3 Transcription Factor; Th1 Cells; Th17 Cells; Thiophenes | 2014 |
S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes.
Topics: Animals; Blood Gas Analysis; Cardiopulmonary Bypass; Cell Count; Coronary Vessels; Fingolimod Hydrochloride; Follow-Up Studies; Interleukin-6; Lymphocytes; Male; Mesenteric Arteries; Oxadiazoles; Propylene Glycols; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Vasoconstriction; Vasodilation | 2014 |
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes | 2014 |
Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment.
Topics: Animals; Cattle; Cell Count; Cell Movement; Delayed-Action Preparations; Gelatin; Humans; Hydrogels; Lactic Acid; Lysophospholipids; Macrophages; Male; Mice, Inbred C57BL; Micelles; Oxadiazoles; Solubility; Sphingosine; Sus scrofa; Thiophenes; Time Factors; Water | 2014 |
High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists.
Topics: Animals; Cell Line; Cell Movement; Cells, Cultured; Fingolimod Hydrochloride; Intracellular Signaling Peptides and Proteins; Lipoproteins, HDL; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxadiazoles; Pertussis Toxin; Propylene Glycols; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; Scavenger Receptors, Class B; Sphingosine; Thiophenes | 2014 |
S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.
Topics: Animals; CD11 Antigens; CD11b Antigen; Cell Movement; Chemokine CCL21; Dendritic Cells; Female; Fingolimod Hydrochloride; Integrin alpha Chains; Lymph Nodes; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Oxadiazoles; Phagocytes; Plague; Propylene Glycols; Receptors, CCR2; Receptors, CCR7; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Yersinia pestis | 2014 |
Dorzolamide-induced relaxation of porcine retinal arterioles in vitro depends on nitric oxide but not on acidosis in vascular smooth muscle cells.
Topics: Acidosis; Animals; Arterioles; Benzopyrans; Bradykinin; Carbonic Anhydrase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Dyes; Hydrogen-Ion Concentration; Lactates; Muscle, Smooth, Vascular; Myography; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Retinal Artery; Sulfonamides; Swine; Thiophenes; Vasodilation | 2014 |
Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse.
Topics: Animals; Capillaries; Dose-Response Relationship, Drug; Kidney; Ligation; Male; Mice; Microcirculation; Molecular Targeted Therapy; Oxadiazoles; Permeability; Punctures; Pyrazoles; Pyridines; Receptors, Lysosphingolipid; Sepsis; Thiophenes; Time Factors | 2015 |
Activation of S1P₁ receptor regulates PI3K/Akt/FoxO3a pathway in response to oxidative stress in PC12 cells.
Topics: Animals; Fingolimod Hydrochloride; Forkhead Box Protein O3; Forkhead Transcription Factors; Neurons; Neuroprotective Agents; Oxadiazoles; Oxidative Stress; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Receptors, Lysosphingolipid; Thiophenes | 2015 |
SEW2871 protects from experimental colitis through reduced epithelial cell apoptosis and improved barrier function in interleukin-10 gene-deficient mice.
Topics: Animals; Apoptosis; CD4-Positive T-Lymphocytes; Colitis; Colon; Crohn Disease; Cytokines; Epithelial Cells; Humans; Immunosuppressive Agents; Interleukin-10; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Thiophenes; Tight Junctions | 2015 |
Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia.
Topics: Animals; Benzimidazoles; Brain; Carotid Stenosis; Cerebral Cortex; Chemokine CCL2; Dementia, Vascular; Disease Models, Animal; Drug Evaluation, Preclinical; Maze Learning; Mice, Inbred C57BL; Oxadiazoles; Receptor, Angiotensin, Type 2; Regional Blood Flow; RNA, Messenger; Sulfonamides; Thiophenes; Tumor Necrosis Factor-alpha | 2015 |
Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
Topics: Animals; Data Interpretation, Statistical; Flow Cytometry; Graft Rejection; Graft Survival; Heart Transplantation; Kaplan-Meier Estimate; Leukocyte Count; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Spleen; Th1 Cells; Th2 Cells; Thiophenes; Time Factors; Transplantation, Heterotopic | 2015 |
Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Fingolimod Hydrochloride; Inflammation; Lipopolysaccharides; Lysophospholipids; Male; Maze Learning; Memory Disorders; Oxadiazoles; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Tumor Necrosis Factor-alpha | 2015 |
Highly selective and sensitive fluorescence chemosensor for the detection of palladium species based on Tsuji-Trost reaction.
Topics: Carbamates; Fluorescence; Fluorescent Dyes; Limit of Detection; Oxadiazoles; Palladium; Polyethylene Glycols; Spectrometry, Fluorescence; Thiophenes | 2015 |
SEW2871 Alleviates the Severity of Caerulein-Induced Acute Pancreatitis in Mice.
Topics: Amylases; Animals; Ceruletide; Cytokines; Lipase; Male; Mice, Inbred ICR; Oxadiazoles; Pancreas; Pancreatitis; Peroxidase; RNA, Messenger; STAT3 Transcription Factor; T-Lymphocytes; Thiophenes | 2015 |
Sphingosine-1-Phosphate Receptor-1 Selective Agonist Enhances Collateral Growth and Protects against Subsequent Stroke.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Endothelial Cells; Male; Mice; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Stroke; Thiophenes; Time Factors | 2015 |
S1P1 deletion in oligodendroglial lineage cells: Effect on differentiation and myelination.
Topics: Animals; Cell Survival; Corpus Callosum; Extracellular Signal-Regulated MAP Kinases; Mice, Inbred C57BL; Mice, Knockout; Myelin Basic Protein; Neurogenesis; Oligodendroglia; Oxadiazoles; Oxidative Stress; p21-Activated Kinases; Phosphorylation; Receptors, Lysosphingolipid; Thiophenes | 2016 |
Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure.
Topics: Animals; Cattle; Cell Movement; Cells, Cultured; Chemokine CXCL12; Delayed-Action Preparations; Gelatin; Hydrogels; Lysophospholipids; Macrophages; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Oxadiazoles; Skin; Sphingosine; Swine; Thiophenes; Wound Healing | 2016 |
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
Topics: Animals; Antiviral Agents; Cell Line; Dengue; Dengue Virus; Humans; Oxadiazoles; RNA-Dependent RNA Polymerase; Thiophenes; Viral Nonstructural Proteins | 2016 |
The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Astrocytes; Azetidines; Benzyl Compounds; beta-Alanine; Calcium Signaling; Cerebellum; Demyelinating Diseases; eIF-2 Kinase; Humans; Immunosuppressive Agents; In Vitro Techniques; Indans; Interleukin-6; Lysophosphatidylcholines; Mice; Myelin Basic Protein; Organ Culture Techniques; Oxadiazoles; Protein Transport; Receptors, Lysosphingolipid; Thiophenes; Time Factors | 2016 |
Fingolimod confers neuroprotection through activation of Rac1 after experimental germinal matrix hemorrhage in rat pups.
Topics: Animals; Body Water; Brain; Brain Chemistry; Brain Edema; Cognition; Female; Fingolimod Hydrochloride; Intracranial Hemorrhages; Leukocyte Count; Male; Neuroprotective Agents; Oxadiazoles; Phosphoserine; Pregnancy; Pyrones; Quinolines; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Thiophenes; Tight Junction Proteins | 2017 |
The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices.
Topics: Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Blotting, Western; Central Nervous System Agents; Drug Evaluation, Preclinical; Hippocampus; Isoxazoles; Male; Molecular Structure; Oxadiazoles; Phosphorylation; Protein Phosphatase 2; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; tau Proteins; Thiophenes; Tissue Culture Techniques | 2017 |
Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure-activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent.
Topics: Cell Line; Cell Proliferation; Humans; Keratinocytes; Oxadiazoles; Quinones; Structure-Activity Relationship; Superoxides; Thiophenes | 2017 |
Sphingosine-1-Phosphate Receptor-1 Agonist Sew2871 Causes Severe Cardiac Side Effects and Does Not Improve Microvascular Barrier Breakdown in Sepsis.
Topics: Animals; Disease Models, Animal; Humans; Lysophospholipids; Male; Oxadiazoles; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sepsis; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiophenes; Tumor Necrosis Factor-alpha | 2018 |
Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzylamines; Caspase 3; Caspase 7; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Box Protein O1; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Inhibitory Concentration 50; Mesothelioma; Oxadiazoles; Phosphorylation; Phosphorylcholine; Pleural Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinoxalines; Sulfonamides; Thiadiazoles; Thiophenes | 2017 |
A selective sphingosine-1-phosphate receptor 1 agonist SEW-2871 aggravates gastric cancer by recruiting myeloid-derived suppressor cells.
Topics: Animals; Cell Movement; Cell Proliferation; Cytokines; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; Neoplasms, Experimental; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Stomach Neoplasms; T-Lymphocytes, Cytotoxic; Thiophenes; Tumor Cells, Cultured; Tumor Microenvironment | 2018 |
Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn.
Topics: Anilides; Animals; Central Nervous System Sensitization; Disease Models, Animal; eIF-2 Kinase; Female; Fingolimod Hydrochloride; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Motor Activity; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Neuralgia; Organophosphonates; Oxadiazoles; Pain Threshold; Peptide Fragments; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Spinal Cord; Spinal Nerve Roots; Subcellular Fractions; Thiophenes | 2018 |
Sinusoidal protection by sphingosine-1-phosphate receptor 1 agonist in liver ischemia-reperfusion injury.
Topics: Animals; Antigens, CD; Cadherins; Cytokines; Drug Evaluation, Preclinical; Endothelial Cells; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Oxadiazoles; Proto-Oncogene Proteins c-akt; Random Allocation; Receptors, Lysosphingolipid; Reperfusion Injury; Sphingosine-1-Phosphate Receptors; Thiophenes; Vascular Cell Adhesion Molecule-1 | 2018 |
Sphingosine-1-Phosphate Receptor 1 Activation Enhances Leptomeningeal Collateral Development and Improves Outcome after Stroke in Mice.
Topics: Animals; Blood-Brain Barrier; Cell Line; Cerebrovascular Circulation; Collateral Circulation; Disease Models, Animal; Endothelial Cells; Infarction, Middle Cerebral Artery; Macrophages; Male; Meninges; Mice, Inbred BALB C; Monocytes; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Oxadiazoles; Phosphorylation; Receptors, Lysosphingolipid; Recovery of Function; Signal Transduction; Sphingosine-1-Phosphate Receptors; Thiophenes; Tight Junction Proteins; Time Factors | 2018 |
Fusing Benzo[c][1,2,5]oxadiazole Unit with Thiophene for Constructing Wide-bandgap High-performance IDT-based Polymer Solar Cell Donor Material.
Topics: Oxadiazoles; Polymers; Solar Energy; Thiophenes | 2018 |
Synthesis and antifungal activities of novel thiophene-based stilbene derivatives bearing an 1,3,4-oxadiazole unit.
Topics: Botrytis; Fungicides, Industrial; Microbial Sensitivity Tests; Oxadiazoles; Phyllachorales; Stilbenes; Thiophenes | 2019 |
Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.
Topics: Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Fungal Proteins; HEK293 Cells; Hep G2 Cells; Humans; IMP Dehydrogenase; Models, Molecular; Oxadiazoles; Thiophenes | 2018 |
The role of ceramide and SEW 2871 in the transcription of enzymes involved in amyloid b precursor protein metabolism in an experimental model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ceramides; Humans; Lysophospholipids; Models, Theoretical; Neurons; Oxadiazoles; PC12 Cells; Rats; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Transcription, Genetic | 2018 |
Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway.
Topics: Animals; Astrocytes; Caspase 1; Hyperalgesia; Inflammasomes; Interleukin-1beta; Male; Mice; Mice, Transgenic; NLR Family, Pyrin Domain-Containing 3 Protein; Oxadiazoles; Pain Measurement; Pain Threshold; Rats, Sprague-Dawley; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Spinal Cord; Thiophenes | 2019 |
Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages.
Topics: Animals; Antigens, CD; Fibrin; Gene Expression Regulation; Hydrogels; Inflammation; Interleukin-10; Macrophages; Male; Mice; Oxadiazoles; Thiophenes; Tumor Necrosis Factor-alpha | 2019 |
Modulating sphingosine-1-phosphate receptors to improve chemotherapy efficacy against Ewing sarcoma.
Topics: Animals; Antibiotics, Antineoplastic; Bone Neoplasms; Capillary Permeability; Cell Line, Tumor; Doxorubicin; Endothelial Cells; Humans; Mice, Nude; Oxadiazoles; Pyrazoles; Pyridines; Sarcoma, Ewing; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Thiophenes; Treatment Outcome; Xenograft Model Antitumor Assays | 2020 |
Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1.
Topics: Animals; Animals, Newborn; Biomarkers; Cell Differentiation; Collagen; Fibroblasts; Gene Expression Regulation; Hypertrophy; Janus Kinases; Lysophospholipids; Matrix Metalloproteinase 2; Models, Biological; Myocardium; Myocytes, Cardiac; Oxadiazoles; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Smad2 Protein; Sphingosine; STAT Transcription Factors; Thiophenes; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2020 |
Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus.
Topics: Anti-Bacterial Agents; Capsaicin; Cell Survival; Drug Design; Drug Resistance, Multiple; HEK293 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxadiazoles; Staphylococcal Infections; Structure-Activity Relationship; Thiophenes; Vancomycin | 2020 |
Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis.
Topics: Animals; Anti-Inflammatory Agents; beta-Alanine; Cell Line; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glutamates; Indans; Interleukin-1beta; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Neostriatum; Oxadiazoles; RNA, Messenger; Sphingosine-1-Phosphate Receptors; Synapses; Synaptic Transmission; T-Lymphocytes; Thiophenes | 2020 |
Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.
Topics: 1-Naphthylisothiocyanate; Animals; Bile Acids and Salts; Cholestasis; Down-Regulation; Hepatocytes; Homeostasis; Liver; Male; Mice, Inbred C57BL; Oxadiazoles; Sphingosine-1-Phosphate Receptors; Thiophenes; Tight Junctions | 2020 |
miR-140 ameliorates neuropathic pain in CCI rats by targeting S1PR1.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Gene Expression Profiling; HEK293 Cells; Humans; Inflammation; Male; MicroRNAs; Neuralgia; Neuroinflammatory Diseases; Oxadiazoles; Rats; Rats, Wistar; Sphingosine-1-Phosphate Receptors; Stress, Mechanical; Thiophenes | 2021 |
SEW2871 attenuates ANIT-induced hepatotoxicity by protecting liver barrier function via sphingosine 1-phosphate receptor-1-mediated AMPK signaling pathway.
Topics: 1-Naphthylisothiocyanate; AMP-Activated Protein Kinases; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Liver; Mice; Oxadiazoles; Signal Transduction; Sphingosine-1-Phosphate Receptors; Tandem Mass Spectrometry; Thiophenes | 2021 |
Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis.
Topics: Animals; Capillary Permeability; Cell Line, Tumor; Endothelial Cells; Humans; Liposomes; Mice; Myosin Light Chains; Nanoparticles; Neoplasm Metastasis; Oxadiazoles; Phosphorylation; Signal Transduction; Sphingosine-1-Phosphate Receptors; Thiophenes | 2021 |
The S1PR1 agonist SEW2871 promotes the survival of skin flap.
Topics: Angiogenesis Inducing Agents; Animals; Apoptosis; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Graft Survival; HSP27 Heat-Shock Proteins; Oxadiazoles; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Skin; Skin Transplantation; Sphingosine-1-Phosphate Receptors; Surgical Flaps; Thiophenes | 2021 |
New Drugs 2021, Part 2.
Topics: Adenosine Monophosphate; Alanine; Amisulpride; Carbamates; Cefiderocol; Cephalosporins; Chlorophenols; COVID-19 Drug Treatment; Drug Approval; Drug Combinations; Fumarates; Humans; Indans; Organophosphates; Oxadiazoles; Piperazines; Spiro Compounds; Tetrazoles; Thiophenes; Tromethamine; United States; United States Food and Drug Administration | 2021 |
Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.
Topics: Adenosine; Adenosine Kinase; Animals; Hyperalgesia; Inflammasomes; Interleukin-1beta; NLR Proteins; Oxadiazoles; Rats; Rats, Sprague-Dawley; Sphingosine-1-Phosphate Receptors; Spinal Cord Dorsal Horn; Thiophenes | 2022 |
Sphingosine-1-phosphate receptor 1 agonist SEW2871 alters membrane properties of late-firing somatostatin expressing neurons in the central lateral amygdala.
Topics: Action Potentials; Animals; Central Amygdaloid Nucleus; Female; Gene Expression; Male; Membrane Potentials; Mice; Mice, Transgenic; Neurons; Organ Culture Techniques; Oxadiazoles; Somatostatin; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Thiophenes | 2022 |
S1P analogues SEW2871, BAF312 and FTY720 affect human Th17 and Treg generation ex vivo.
Topics: Animals; Azetidines; Benzyl Compounds; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Interleukin-23; Lysophospholipids; Mice; Neurodegenerative Diseases; Oxadiazoles; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes, Regulatory; Th17 Cells; Thiophenes | 2022 |