Compounds > thiophenes
Page last updated: 2024-08-18

thiophenes and nolatrexed

thiophenes has been researched along with nolatrexed in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (42.86)18.2507
2000's6 (42.86)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
DeGoeij, K; Mester, J; Sluyser, M1
Jansen, G; Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B1
Takimoto, CH1
Banerjee, D; Bertino, JR; Ercikan-Abali, EA; Liu-Chen, X; Maley, F; Tong, Y; Zhao, SC1
Danenberg, PV; Malli, H; Swenson, S1
Kuiper, CM; Peters, GJ; van der Wilt, CL1
Strømhaug, A; Warren, DJ1
Aherne, GW; Brunton, L; Jackman, AL; Monaghan, P; Titley, J; Valenti, M; Welsh, SJ1
Cassidy, J1
Backus, HH; Kuiper, CM; Peters, GJ; Pinedo, HM; van der Wilt, CL; van Groeningen, CJ; Wouters, D1
Callender, MA; Chu, E; Farrell, MP; Schmitz, JC1
Fukushima, M; Hoogeland, MF; Peters, GJ; Temmink, OH1
Contestabile, R; Cutruzzolà, F; Daidone, F; Fiascarelli, A; Giardina, G; Koes, DR; Marani, M; McDermott, LA; Montini, G; Paiardini, A; Paone, A; Parroni, A; Rinaldo, S1
Chen, D; Jansson, A; Larsson, A; Nordlund, P; Sim, D1

Reviews

4 review(s) available for thiophenes and nolatrexed

ArticleYear
Antifolates in clinical development.
    Seminars in oncology, 1997, Volume: 24, Issue:5 Suppl 18

    Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase

1997
Thymidylate synthase inhibitors.
    Seminars in oncology, 1999, Volume: 26, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase

1999
Thymidylate synthase inhibitors in colorectal cancer.
    Seminars in oncology, 2000, Volume: 27, Issue:5 Suppl 10

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase

2000
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52 Suppl 1

    Topics: Antineoplastic Agents; Enzyme Inhibitors; Humans; Indoles; Isoindoles; Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Thymidylate Synthase

2003

Other Studies

10 other study(ies) available for thiophenes and nolatrexed

ArticleYear
Modulation of [5-125I]iododeoxyuridine incorporation into tumour and normal tissue DNA by methotrexate and thymidylate synthase inhibitors.
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Female; Fluorouracil; Idoxuridine; Intestine, Small; Iodine Radioisotopes; Liver; Mammary Neoplasms, Experimental; Methotrexate; Mice; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Quinazolines; Thiophenes; Thymidylate Synthase; Uracil

1996
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
    Biochemical pharmacology, 1997, Jun-15, Volume: 53, Issue:12

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Humans; Indoles; Isoindoles; Methotrexate; Peptide Synthases; Polymerase Chain Reaction; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

1997
Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.
    The Journal of biological chemistry, 1998, Nov-20, Volume: 273, Issue:47

    Topics: Animals; Antimetabolites, Antineoplastic; Binding Sites; Bone Marrow Cells; Drug Resistance; Folic Acid; Folic Acid Antagonists; Granulocytes; Humans; Indoles; Isoindoles; Isoleucine; Kinetics; Macrophages; Mice; Models, Molecular; Mutagenesis, Site-Directed; Quinazolines; Recombinant Proteins; Stem Cells; Thiophenes; Thymidylate Synthase

1998
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
    Oncology research, 1999, Volume: 11, Issue:8

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; DNA Damage; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

1999
A comparison of the effects of nine folate analogs on early and late murine hematopoietic progenitor cells in vitro.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:6

    Topics: Aminopterin; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Hematopoietic Stem Cells; Methotrexate; Mice; Mice, Inbred BALB C; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate

2000
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:6

    Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Flow Cytometry; Fluorouracil; Glutamates; Guanine; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Mice; Mice, Inbred DBA; Microscopy, Confocal; Neoplasm Transplantation; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured; Up-Regulation

2000
Thymidylate synthase inhibition induces p53 dependent and independent cell death.
    Advances in experimental medicine and biology, 2000, Volume: 486

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; DNA Damage; Enzyme Inhibitors; Fas Ligand Protein; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Membrane Glycoproteins; Pemetrexed; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2000
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
    Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:2

    Topics: Antimetabolites; Colonic Neoplasms; DNA Damage; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homeostasis; Humans; Indoles; Isoindoles; Quinazolines; Thiophenes; Trifluridine; Tumor Cells, Cultured

2006
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.
    ChemMedChem, 2015, Volume: 10, Issue:3

    Topics: Folic Acid Antagonists; Glycine Hydroxymethyltransferase; Humans; Methotrexate; Molecular Docking Simulation; Quinazolines; Tetrahydrofolates; Thiophenes

2015
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
    The Journal of biological chemistry, 2017, 08-11, Volume: 292, Issue:32

    Topics: Allosteric Site; Amino Acid Substitution; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Deoxyuracil Nucleotides; Dimerization; Enzyme Activation; Enzyme Stability; Folic Acid Antagonists; Humans; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Protein Conformation; Protein Folding; Quinazolines; Recombinant Proteins; Thiophenes; Thymidylate Synthase

2017