thiophenes has been researched along with nb 598 in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (66.67) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Hidaka, Y; Horie, M; Ishida, F; Kamei, T; Nagata, Y; Watanabe, H; Yonemoto, M | 1 |
| Eda, T; Hidaka, Y; Kamei, T; Yonemoto, M | 1 |
| Hidaka, Y; Horie, M; Hotta, H; Iwasawa, Y; Kamei, T; Nagata, Y | 1 |
| Fukuzumi, H; Horie, M; Iizuka, Y; Kamei, T; Sawasaki, Y; Tsuchiya, Y; Watanabe, K | 1 |
| Fukuzumi, H; Hayashi, M; Horie, M; Iida, Y; Iwasawa, Y; Kamei, T; Kitani, K; Nagata, Y; Sawasaki, Y; Tsuchiya, Y | 1 |
| Kamei, T; Nagumo, A; Ono, T; Sakakibara, J | 1 |
| Fisher, PL; Fliesler, SJ; Keller, PK; Pittler, SJ; Rapp, LM | 1 |
| Fliesler, SJ; Florman, R; Keller, RK; Pittler, SJ; Rapp, LM | 1 |
| Correll, CC; Edwards, PA | 1 |
| Horie, M; Iwasawa, Y; Kamei, T; Nagata, Y; Satoh, T; Shimizu, A | 1 |
| Horie, M; Kamei, T; Satoh, T; Tsuchiya, Y; Watanabe, H | 1 |
| Hayashi, M; Horie, M; Hotta, H; Ishida, F; Kamei, T; Nagata, Y; Satoh, T | 1 |
| Izumi, T; Nakamura, Y; Ono, T; Sakakibara, J; Shibata, A | 1 |
| Alaei, P; MacNulty, EE; Ryder, NS | 1 |
| Arnaboldi, L; Corsini, A; Ferri, N; Fumagalli, R; Granata, A; Paoletti, R; Quarato, P | 1 |
| Gohda, M; Hanasaki, Y; Ishida, N; Itoh, H; Katsuura, K; Matzno, S; Nakamura, N; Tokunaga, T; Yamauchi, T | 1 |
| Denner-Ancona, P; Lee, HK; Ono, T; Prestwich, GD; Sakakibara, J | 1 |
| Yamashita, S | 1 |
| Abe, S; Hiyoshi, H; Ikuta, H; Ito, M; Kurusu, N; Okada, T; Saeki, T; Shinmyo, D; Tanaka, H; Tanaka, K; Yanagimachi, M; Yasuda, N; Yoshida, I | 1 |
| Belani, JD; Cohen, JC; Hobbs, HH; Rawson, RB; Rychnovsky, SD; Xu, F | 1 |
| Chen, Y; Gaisano, HY; Gao, X; Mihic, A; Tsushima, RG; Xia, F; Xie, L | 1 |
| Boerner, JL; Bohin, N; Ge, Y; Irwin, ME; Mueller, KL | 1 |
| Brown, AJ; Chua, NK; Coates, HW; Hashimoto, Y; Ohgane, K; Yoshioka, H | 1 |
| Leaver, DJ; Madan, B; Nes, WD; Virshup, DM | 1 |
2 review(s) available for thiophenes and nb 598
| Article | Year |
|---|---|
[Other antihyperlipidemic drugs with novel mechanism].
Topics: Animals; Arteriosclerosis; Azetidines; Benzylamines; Carrier Proteins; CCAAT-Enhancer-Binding Proteins; Chenodeoxycholic Acid; Cholesterol; Coronary Disease; Diphosphonates; DNA-Binding Proteins; Ezetimibe; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hyperlipidemias; Hypolipidemic Agents; Lithocholic Acid; Organic Anion Transporters, Sodium-Dependent; Oxygenases; Squalene Monooxygenase; Sterol Regulatory Element Binding Protein 1; Symporters; Thiophenes; Transcription Factors | 2001 |
Unearthing the Janus-face cholesterogenesis pathways in cancer.
Topics: Animals; Anticholesteremic Agents; Antineoplastic Agents; Benzylamines; Cholesterol; Humans; Lanosterol; Neoplasms; Terbinafine; Thiophenes | 2022 |
22 other study(ies) available for thiophenes and nb 598
| Article | Year |
|---|---|
Effect of an inhibitor of squalene epoxidase, NB-598, on lipid metabolism in Hep G2 cells.
Topics: Anticholesteremic Agents; Benzylamines; Bile Acids and Salts; Cholesterol; Cholesterol Esters; Dolichols; Humans; Lipid Metabolism; Oxygenases; Squalene Monooxygenase; Thiophenes; Tumor Cells, Cultured; Ubiquinone | 1992 |
Inhibition of cultured vascular smooth muscle cell migration by simvastatin (MK-733).
Topics: Animals; Anticholesteremic Agents; Aorta, Thoracic; Benzylamines; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Fibrinogen; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Muscle, Smooth, Vascular; Nifedipine; Platelet-Derived Growth Factor; Pravastatin; Simvastatin; Sterols; Swine; Thiophenes | 1992 |
Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells.
Topics: Acetates; Anticholesteremic Agents; Benzylamines; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Cycloheximide; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; Nucleic Acid Hybridization; Oxygenases; RNA, Neoplasm; Simvastatin; Squalene Monooxygenase; Thiophenes | 1991 |
Hypolipidemic effects of NB-598 in dogs.
Topics: Animals; Anticholesteremic Agents; Benzylamines; Bile; Bile Acids and Salts; Cholesterol; Dogs; Feces; Lipids; Lipoproteins; Lovastatin; Male; Oxygenases; Phospholipids; Simvastatin; Squalene; Squalene Monooxygenase; Thiophenes; Triglycerides | 1991 |
NB-598: a potent competitive inhibitor of squalene epoxidase.
Topics: Animals; Anticholesteremic Agents; Benzylamines; Cattle; Cell Line; Cholesterol; Humans; In Vitro Techniques; Kinetics; Lipid Metabolism; Oxygenases; Rats; Squalene; Squalene Monooxygenase; Thiophenes | 1990 |
Purification and characterization of recombinant squalene epoxidase.
Topics: Animals; Base Sequence; Benzylamines; Chromatography; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Female; Gene Expression; Hydrogen-Ion Concentration; Microsomes, Liver; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Octoxynol; Oxygenases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Squalene; Squalene Monooxygenase; Thiophenes | 1995 |
In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure.
Topics: Acetates; Acetylcysteine; Animals; Benzylamines; Cell Nucleus; Cholesterol; Female; Lipids; Lovastatin; Photoreceptor Cells; Protein Prenylation; Rats; Retina; Squalene; Sterols; Thiophenes | 1995 |
In vivo biosynthesis of cholesterol in the rat retina.
Topics: Acetates; Animals; Benzylamines; Cholesterol; Female; Lipid Metabolism; Lovastatin; Oxygenases; Rats; Retina; Squalene Monooxygenase; Thiophenes | 1993 |
Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro.
Topics: Animals; Benzylamines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Enzyme Inhibitors; Hydrolysis; Hydroxymethylglutaryl CoA Reductases; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sterols; Thiophenes; Tricarboxylic Acids | 1994 |
Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells.
Topics: Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins B; Benzylamines; Cell Line; Cell Membrane; Cholesterol; Cholesterol Esters; Enzyme Activation; Humans; Linoleic Acids; Lipids; Lovastatin; Microsomes; Oleic Acid; Oleic Acids; Oxygenases; Polyunsaturated Alkamides; Simvastatin; Squalene Monooxygenase; Sterol O-Acyltransferase; Thiophenes; Tritium; Tumor Cells, Cultured | 1993 |
Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae.
Topics: Animals; Benzylamines; Candida albicans; Enzyme Inhibitors; Flavin-Adenine Dinucleotide; Fungal Proteins; Hydrogen-Ion Concentration; Kinetics; Microsomes; NADP; Naphthalenes; Octoxynol; Oxygenases; Polyethylene Glycols; Rats; Saccharomyces cerevisiae; Species Specificity; Squalene Monooxygenase; Terbinafine; Thiophenes | 1993 |
An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells.
Topics: Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins B; Benzylamines; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Oxygenases; Simvastatin; Squalene; Squalene Monooxygenase; Thiophenes; Triglycerides; Tumor Cells, Cultured | 1993 |
Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells.
Topics: Animals; Benzylamines; Culture Media; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Hydroxymethylglutaryl CoA Reductases; L Cells; Lovastatin; Mice; Molecular Sequence Data; Oxygenases; RNA, Messenger; Squalene Monooxygenase; Sterols; Thiophenes; Transcription, Genetic | 1996 |
Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes.
Topics: Adenosine Triphosphate; Benzylamines; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Inositol 1,4,5-Trisphosphate; Keratinocytes; Mevalonic Acid; Platelet Activating Factor; Protein Prenylation; Signal Transduction; Thiophenes; Thrombin | 1996 |
[Pharmacological control of biosynthesis pathway of mevalonate: effect on the proliferation of arterial smooth muscle cells].
Topics: Animals; Aorta; Benzodiazepines; Benzylamines; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Cholesterol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Oligopeptides; Rats; Rats, Sprague-Dawley; Thiophenes; Tricarboxylic Acids | 1997 |
Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts.
Topics: Actins; Animals; Apoptosis; Benzylamines; Cell Differentiation; Cell Line; Cholesterol; DNA Fragmentation; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle Fibers, Skeletal; Oxygenases; Rats; Simvastatin; Squalene Monooxygenase; Thiophenes | 1997 |
Photoaffinity labeling and site-directed mutagenesis of rat squalene epoxidase.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Benzylamines; Catalytic Domain; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygenases; Photochemistry; Rats; Recombinant Proteins; Squalene Monooxygenase; Thiophenes | 2000 |
Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes.
Topics: Animals; Atorvastatin; Benzylamines; Cells, Cultured; Cholesterol; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Hepatocytes; Heptanoic Acids; Lipid Metabolism; Male; Oxidation-Reduction; Pyrroles; Rats; Rats, Sprague-Dawley; Thiophenes; Triglycerides | 2003 |
Dual roles for cholesterol in mammalian cells.
Topics: Animals; Benzylamines; Cell Proliferation; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Phytosterols; Sitosterols; Thiophenes | 2005 |
Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.
Topics: Animals; Benzylamines; Calcium Channels; Cell Line; Cholesterol; Enzyme Inhibitors; Exocytosis; Insulin; Insulin Secretion; Insulin-Secreting Cells; Membrane Microdomains; Membrane Potentials; Mice; Microscopy, Electron; Potassium Channels; Secretory Vesicles; SNARE Proteins; Squalene Monooxygenase; Thiophenes | 2008 |
Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib.
Topics: Atorvastatin; Benzylamines; beta-Cyclodextrins; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholesterol; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Gefitinib; Heptanoic Acids; Humans; Lovastatin; Membrane Microdomains; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Pyrroles; Quinazolines; Thiophenes | 2011 |
A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate.
Topics: Allosteric Regulation; Benzylamines; Cholesterol; Endoplasmic Reticulum; HEK293 Cells; Humans; Membrane Proteins; Proteostasis; Squalene; Squalene Monooxygenase; Thiophenes; Ubiquitin-Protein Ligases; Ubiquitination | 2020 |