Page last updated: 2024-08-18

thiophenes and morphine

thiophenes has been researched along with morphine in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (15.87)	18.7374
1990's	9 (14.29)	18.2507
2000's	7 (11.11)	29.6817
2010's	19 (30.16)	24.3611
2020's	18 (28.57)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Winter, JC	1
Cowan, A; Wheeler-Aceto, H	2
Binder, D; Enzenhofer, R; Rovenszky, F; Schnait, H; Stroissnig, H	1
Halfpenny, PR; Horwell, DC; Hughes, J; Hunter, JC; Rees, DC	1
Cowan, A; Ianone, M; Porreca, F; Wheeler, H	1
Harbison, WD; Slocombe, RF; Stewart, GA; Watts, SJ	1
Fjalland, B; Lassen, N; Nielsen, IM; Pedersen, V; Petersen, PV	1
Iwata, N; Sakai, Y	1
Imamura, H; Maruyama, Y; Nakanishi, M	2
Hayashi, G; Ishida, R; Kowa, Y	1
Blanchard, JC; Carruette, A; Garret, C; Laduron, PM; Montier, F; Moussaoui, SM	1
Carruette, A; Garret, C; Moussaoui, S	1
Nagasaka, H; Yaksh, TL	1
Grouhel, A; Wettstein, JG	1
Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ	1
Chen, XJ; Chi, ZQ; Dai, QY; Jin, WQ; Liu, ZH; Zhang, HP	1
CHAPPEL, CI; VONSEEMANN, C	1
HAYASHI, G	1
Eisinger, DA; Schulz, R; Wehmeyer, A	1
Jones, CK; Peters, SC; Shannon, HE	1
Leventhal, L; Piesla, M; Wantuch, C	1
Baker, S; Brioni, JD; Chang, R; EI-Kouhen, O; Gauvin, DM; Hernandez, G; Hollingsworth, PR; Honore, P; Lehto, SG; Moreland, RB; Stewart, AO; Zheng, G; Zhu, CZ	1
Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT	1
Dyhr, H; Grunnet, M; Munro, G	1
Chia, SL; Ho, KY; Liu, H; Lo, NN; Tay, W; Yeo, MC; Yeo, SJ	1
Bannon, AW; Decker, MW; Gauvin, D; Hsieh, GC; Joshi, SK; Lee, CH; Lewis, LG; Mikusa, J; Mills, CD; Rueter, LE; Zhong, C; Zhu, CZ	1
Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A	1
Miyazaki, R; Yamamoto, T	1
Elmes, SJ; McIntosh, F; Perkins, MN; Rashid, MH; Theberge, Y	1
Badghisi, H; Meske, DS; Ossipov, MH; Oyarzo, J; Porreca, F; Xie, JY	1
Martin, WJ; Obedencio, GP; Shen, F; Smith, JA; Tsuruda, PR	1
Dickenson, AH	1
Authier, N; Balayssac, D; Eschalier, A; Ferrier, J; Ling, B; Pereira, B	1
Ishikawa, G; Nagakura, Y; Shimizu, Y; Takeshita, N	1
Burnham, N; James, IE; Lark, MW; Sadler, BM; Skobieranda, F; Soergel, DG; Subach, RA; Violin, JD; Webster, LR	1
Alexopoulos, D; Antoniucci, D; Bellandi, B; Capodanno, D; Capranzano, P; Migliorini, A; Parodi, G; Stavrou, K; Tamburino, C; Valenti, R; Xanthopoulou, I	1
Bolognese, JA; Cook, E; Daniels, S; Kuss, M; Skobieranda, F; Soergel, DG; Subach, RA; Viscusi, ER; Webster, L; Zuckerman, S	1
Clark, JD; Irvine, KA; Li, WW; Liang, DY; Nwaneshiudu, C	1
Austin Zamarripa, C; Blough, BE; Edwards, SR; Freeman, KB; Qureshi, HN; Yi, JN	1
Banks, ML; Blough, BE; Faunce, KE; Grim, TW; Negus, SS; Obeng, S; Rice, KC; Schwienteck, KL; Zhang, Y	1
Burt, DA; Demitrack, MA; Salamea, M; Singla, NK; Skobieranda, F; Soergel, DG; Viscusi, ER	1
Benyhe, S; Bojarski, AJ; Buda, S; Bugno, R; Golembiowska, K; Kudla, L; Makuch, W; Przewlocka, B; Przewlocki, R; Skupio, U; Solecki, W; Wiktorowska, L; Wojtas, A; Zádor, F	1
Bouvier, M; Bräuner-Osborne, H; Foster, SR; Gabriele, F; Märcher-Rørsted, E; Matosiuk, D; Møller, TC; Pedersen, DS; Pedersen, H; Pedersen, MF; Wróbel, TM	1
Gan, TJ; Wase, L	1
Ayad, S; Burt, DA; Demitrack, MA; Fossler, MJ; Khanna, AK; Michalsky, C; Wase, L	1
Goddard, WA; Kim, SK; Mafi, A	1
Huang, T; Li, J; Zhao, Z	1
Dahan, A; Demitrack, MA; Fossler, MJ; Niesters, M; Olofsen, E; van Dam, CJ; van Velzen, M	1
Bojarski, AJ; Bugno, R; Kudla, L; Podlewska, S; Przewlocki, R	1
Bergese, S; Berkowitz, R; Cochrane, K; Demitrack, MA; Griffith, S; Habib, AS; Ladouceur, M; Rider, P; Segura Vasi, A; Wase, L	1
Hu, Q; Liu, Y; Yang, J	1
Bong, D; Floyd, C; Liao, S; Pino, MJ; Tan, K; Wu, C	1
Eleswarpu, SS; Habib, AS	1
Baptista-Hon, DT; Camplisson, E; Edelsten, E; Hales, TG; McCaughey, KS; Singleton, S	1
Akbarali, HI; Dewey, WL; Jacob, JC; Muchhala, KH	1
Bondar, AN; Bren, U; Domratcheva, T; Giannos, T; Hodošček, M; Lešnik, S	1
Bergese, SD; Gan, TJ; Gupta, A; Jin, Z; Page, C; Zhu, M	1
Azzam, AAH; Lambert, DG	1
Demitrack, MA; Fossler, MJ; Simpson, KN; Wandstrat, TL; Wase, L	1
Chang, HF; Chang, PW; Chang, YC; Chen, CT; Chuang, JY; Hsu, YT; Huang, YC; Ke, YY; Kuppusamy, R; Lin, YH; Loh, HH; Shih, C; Ueng, SH; Wang, PC; Yeh, SH; Yeh, TK	1

Reviews

3 review(s) available for thiophenes and morphine

Article	Year
ANTITUSSIVE DRUGS. Progress in medicinal chemistry, 1963, Volume: 19 Topics: Antipsychotic Agents; Antitussive Agents; Chemistry, Pharmaceutical; Codeine; Cough; Dextromoramide; Drug Therapy; Humans; Meperidine; Methadone; Morphine; Pharmacology; Phenothiazines; Phenylacetates; Piperazines; Piperidines; Research; Thiophenes	1963
Oliceridine in the treatment of moderate to severe acute pain. Pain management, 2021, Volume: 11, Issue:3 Topics: Acute Pain; Analgesics, Opioid; Humans; Morphine; Receptors, Opioid, mu; Spiro Compounds; Thiophenes	2021
Evaluating oliceridine as a treatment option for moderate to severe acute post-operative pain in adults. Expert opinion on pharmacotherapy, 2022, Volume: 23, Issue:1 Topics: Acute Pain; Adult; Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Postoperative Nausea and Vomiting; Spiro Compounds; Thiophenes	2022

Trials

4 trial(s) available for thiophenes and morphine

Article	Year
Duloxetine reduces morphine requirements after knee replacement surgery. British journal of anaesthesia, 2010, Volume: 105, Issue:3 Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Double-Blind Method; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Follow-Up Studies; Humans; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Postoperative Care; Selective Serotonin Reuptake Inhibitors; Thiophenes; Young Adult	2010
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. Pain, 2014, Volume: 155, Issue:9 Topics: Adolescent; Adult; Analgesia; Analgesics, Opioid; Cross-Over Studies; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Headache; Healthy Volunteers; Humans; Male; Middle Aged; Morphine; Pain; Spiro Compounds; Thiophenes; Vomiting; Young Adult	2014
A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain. Pain, 2016, Volume: 157, Issue:1 Topics: Acute Pain; Adolescent; Adult; Aged; Analgesics, Opioid; Double-Blind Method; Female; Hallux Valgus; Humans; Male; Middle Aged; Morphine; Orthopedic Procedures; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Treatment Outcome; Young Adult	2016
APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty. Pain practice : the official journal of World Institute of Pain, 2019, Volume: 19, Issue:7 Topics: Abdominoplasty; Acute Pain; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Receptors, Opioid, mu; Spiro Compounds; Thiophenes	2019

Other Studies

56 other study(ies) available for thiophenes and morphine

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
Morphine and ethanol as discriminative stimuli: absence of antagonism by p-chlorophenylalanine methyl ester, cinanserin, or BC-105. Psychopharmacology, 1977, Jul-18, Volume: 53, Issue:2 Topics: Animals; Cinanserin; Cinnamates; Discrimination, Psychological; Drug Interactions; Ethanol; Female; Fenclonine; Morphine; Pizotyline; Rats; Serotonin Antagonists; Thiophenes	1977
Involvement of a peripheral component in the antinociceptive effects of opioids in a model of tonic pain. NIDA research monograph, 1990, Volume: 105 Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Morphine; Narcotics; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1990
[Thiophene as a structural element of physiologically active compounds. 19. The synthesis of substituted (6H-thieno[2,3-b]pyrrol-4-yl)phenylmethanones]. Archiv der Pharmazie, 1991, Volume: 324, Issue:4 Topics: Analgesics; Animals; Indoles; Mice; Morphine; Morpholines; Pain; Rats; Thiophenes	1991
Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology, 1991, Volume: 104, Issue:1 Topics: Analgesics; Animals; Aspirin; Behavior, Animal; Decerebrate State; Foot; Formaldehyde; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Reference Standards; Thiophenes	1991
Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives. Journal of medicinal chemistry, 1990, Volume: 33, Issue:1 Topics: Analgesia; Animals; Chemical Phenomena; Chemistry; Cyclohexanes; Molecular Structure; Morphine; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Thiophenes	1990
Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats. Proceedings of the Western Pharmacology Society, 1989, Volume: 32 Topics: Animals; Colon; Dose-Response Relationship, Drug; Formaldehyde; Gastrointestinal Transit; Male; Morphine; Pain; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes	1989
Assessment of analgesia and other effects of morphine and thiambutene in the mouse and cat. Australian veterinary journal, 1973, Volume: 49, Issue:11 Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Cats; Diethylamines; Dilatation; Dose-Response Relationship, Drug; Electric Stimulation; Lethal Dose 50; Mice; Morphine; Motor Activity; Physical Stimulation; Pupil; Stimulation, Chemical; Tail; Thiophenes	1973
Anti-nociceptive activity of some thiophthalanes with morphine-like properties. Acta pharmacologica et toxicologica, 1973, Volume: 32, Issue:3 Topics: Analgesia; Analgesics; Animals; Bridged-Ring Compounds; Depression, Chemical; Dextropropoxyphene; Dimethylamines; Electric Stimulation; Ketones; Male; Meperidine; Methadone; Mice; Morphine; Pain; Piperidines; Thiophenes	1973
Effects of some narcotic analgesics and related compounds upon the extensor monosynaptic reflex inhibition from cutaneous nerve and high threshold muscle afferents. Japanese journal of pharmacology, 1971, Volume: 21, Issue:4 Topics: Amines; Analgesics; Animals; Aspirin; Bridged-Ring Compounds; Cats; Citrates; Depression, Chemical; Fentanyl; Heterocyclic Compounds; Levallorphan; Morphine; Muscles; Nalorphine; Narcotics; Neurons, Afferent; Pentazocine; Reflex, Monosynaptic; Skin; Spinal Cord; Thebaine; Thiophenes	1971
[Studies on anti-inflammatory agents. IV. On the appearance of physical dependence and analgesic activity of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6-7-tetrahydrothieno(2,3-c)pyridine (Y-3642) by repeated administration]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1970, Volume: 90, Issue:3 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Body Weight; Diet; Drug Tolerance; Humans; Injections, Intraperitoneal; Injections, Subcutaneous; Levallorphan; Male; Morphine; Pain; Pyridines; Rats; Substance-Related Disorders; Sulfhydryl Compounds; Thiophenes; Water	1970
[Studies on anti-inflammatory agents. II. Analgesic and anti-edematous activities of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6, 7-tetrahydrothieno (2,3-c)pyridine (Y-3642)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1970, Volume: 90, Issue:3 Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Imipramine; Male; Mice; Morphine; Pain; Papaverine; Phenylbutazone; Pyridines; Rats; Salicylates; Thiophenes	1970
[Studies on analgesics. (5). Electroencephalographic studies of the effect of aminoalkylacylaminothiophene on the central nervous system]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1965, Jul-20, Volume: 61, Issue:4 Topics: Analgesics; Animals; Brain; Electroencephalography; Morphine; Nalorphine; Rabbits; Thiophenes	1965
A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically. British journal of pharmacology, 1993, Volume: 109, Issue:1 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Capsaicin; Electric Stimulation; Indoles; Inflammation; Injections, Intravenous; Isoindoles; Male; Morphine; Mucus; Nasal Mucosa; Pyrroles; Rats; Rats, Wistar; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Substance P; Synapses; Thiophenes; Xylenes	1993
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists. Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2 Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Isoindoles; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Peripheral Nerves; Pyrroles; Rats; Rats, Sprague-Dawley; Substance P; Thiophenes	1993
Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats. Anesthesia and analgesia, 1995, Volume: 80, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Anesthesia, Inhalation; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Halothane; Heart Rate; Hot Temperature; Injections, Spinal; Male; Morphine; Nalbuphine; Nociceptors; Pain Threshold; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Reflex; Thiophenes	1995
Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay. Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1996
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats. Life sciences, 1997, Volume: 60, Issue:9 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes	1997
Opioid activity of C8813, a novel and potent opioid analgesic. Life sciences, 2003, May-30, Volume: 73, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Cyclohexanols; Enkephalin, D-Penicillamine (2,5)-; Female; Fentanyl; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine; Pyrrolidines; Rabbits; Thiophenes	2003
[STUDIES ON THE ANALGESICS (REPORT 4). THE EFFECTS OF AMINOALKYLACYLAMINOTHIOPHENE DERIVATIVES ON THE METABOLISM OF BRAIN ACETYLCHOLINE]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1964, Volume: 60 Topics: Acetylcholine; Amino Alcohols; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Brain; Choline; Cholinesterases; Meperidine; Mice; Morphine; Nalorphine; Pharmacology; Research; Thiophenes; Transferases	1964
Opioid control of MAP kinase cascade. European journal of pharmacology, 2004, Oct-01, Volume: 500, Issue:1-3 Topics: Cell Line; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Etorphine; Humans; Ligands; MAP Kinase Signaling System; Morphine; Naloxone; Narcotics; Oligopeptides; Phenylalanine; Phosphorylation; Receptors, sigma; Thiophenes; Transfection	2004
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2 Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes	2005
Pharmacological validation of a model of cystitis pain in the mouse. Neuroscience letters, 2007, Jun-29, Volume: 421, Issue:3 Topics: Analgesics; Animals; Behavior, Animal; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Ketorolac; Male; Mice; Morphine; Pain; Pain Measurement; Thiophenes	2007
Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats. European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3 Topics: Analgesics, Non-Narcotic; Animals; Calcium; Cell Membrane; Cerebellum; Dimethylamines; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fluorometry; Glycine; Heterocyclic Compounds, 3-Ring; Hindlimb; Male; Molecular Structure; Morphine; Pain, Postoperative; Pyridines; Pyrimidinones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Rotarod Performance Test; Thiophenes; Tritium	2008
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. Brain research, 2009, Oct-27, Volume: 1295 Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Edema; Freund's Adjuvant; Gabapentin; Gait; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Male; Morphine; Neuralgia; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Thiophenes	2009
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594. Neuropharmacology, 2010, Volume: 59, Issue:3 Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Duloxetine Hydrochloride; Exploratory Behavior; Gabapentin; gamma-Aminobutyric Acid; Male; Mecamylamine; Morphine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Thiophenes	2010
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain. European journal of pain (London, England), 2012, Volume: 16, Issue:6 Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ibuprofen; Lameness, Animal; Male; Morphine; Motor Activity; Neuritis; Rats; Rats, Sprague-Dawley; Thiophenes	2012
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function. Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:3 Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes	2012
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. Anesthesia and analgesia, 2012, Volume: 115, Issue:1 Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Morphine; Neuralgia; Neuroma; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley; Thiophenes; Time Factors	2012
Pharmacological validation of early and late phase of rat mono-iodoacetate model using the Tekscan system. European journal of pain (London, England), 2013, Volume: 17, Issue:2 Topics: Alkylating Agents; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chronic Disease; Dexamethasone; Dinoprostone; Disease Models, Animal; Duloxetine Hydrochloride; Hindlimb; Iodoacetates; Male; Morphine; Muscle Fibers, Skeletal; Naproxen; Neurons, Afferent; Pain Measurement; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Restraint, Physical; Synovial Fluid; Thiophenes; Weight-Bearing	2013
Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neuroscience letters, 2014, Mar-06, Volume: 562 Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Male; Morphine; Neuralgia; Norepinephrine; Pain Measurement; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Tapentadol; Thiophenes	2014
Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model. PloS one, 2013, Volume: 8, Issue:9 Topics: Analgesia; Animals; Atomoxetine Hydrochloride; Biogenic Monoamines; Chromatography, Liquid; Drug Synergism; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Morphine; Morpholines; Neurotransmitter Uptake Inhibitors; Nociceptive Pain; Norepinephrine Plasma Membrane Transport Proteins; Ondansetron; Propylamines; Rats; Rotarod Performance Test; Serotonin Plasma Membrane Transport Proteins; Tandem Mass Spectrometry; Thiophenes	2013
Commentary on: Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain. Neuroscience letters, 2014, Mar-06, Volume: 562 Topics: Analgesics, Opioid; Animals; Duloxetine Hydrochloride; Male; Morphine; Neuralgia; Phenols; Spinal Nerves; Tapentadol; Thiophenes	2014
Assessment of thermal sensitivity in rats using the thermal place preference test: description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models. Behavioural pharmacology, 2014, Volume: 25, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cold Temperature; Conditioning, Psychological; Disease Models, Animal; Duloxetine Hydrochloride; Hot Temperature; Hyperalgesia; Male; Morphine; Organoplatinum Compounds; Oxaliplatin; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Space Perception; Temperature; Thiophenes	2014
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis. European journal of pharmacology, 2014, Sep-05, Volume: 738 Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxetine Hydrochloride; Gait; Iodoacetic Acid; Male; Morphine; Movement; Osteoarthritis; Pain; Rats; Rest; Thiophenes; Tramadol; Weight-Bearing	2014
Morphine is associated with a delayed activity of oral antiplatelet agents in patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention. Circulation. Cardiovascular interventions, 2015, Volume: 8, Issue:1 Topics: Acute Disease; Adenosine; Age Factors; Aged; Analgesics, Opioid; Drug Interactions; Electrocardiography; Female; Humans; Male; Middle Aged; Morphine; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticagrelor	2015
Pharmacological Characters of Oliceridine, a μ-Opioid Receptor G-Protein-Biased Ligand in Mice. Anesthesia and analgesia, 2019, Volume: 129, Issue:5 Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Ligands; Male; Mice; Mice, Inbred C57BL; Morphine; Pain, Postoperative; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Tibial Fractures; Toll-Like Receptor 4	2019
The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats. Drug and alcohol dependence, 2018, 11-01, Volume: 192 Topics: Analgesics; Analgesics, Opioid; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; GTP-Binding Proteins; Male; Morphine; Oxycodone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reinforcement, Psychology; Spiro Compounds; Thiophenes; Treatment Outcome	2018
Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats. Neuropharmacology, 2019, 05-15, Volume: 150 Topics: Analgesics, Opioid; Animals; Discrimination Learning; Female; Fentanyl; Male; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds; Thiophenes	2019
Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine. British journal of pharmacology, 2019, Volume: 176, Issue:23 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Injections, Intravenous; Injections, Spinal; Locomotion; Male; Mice; Mice, Inbred C57BL; Morphine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; Thiophenes; Urea	2019
Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics. Neuropharmacology, 2020, Volume: 166 Topics: Amino Acid Sequence; Analgesics, Opioid; Buprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; HEK293 Cells; Humans; Kinetics; Morphine; Protein Binding; Receptors, Opioid, mu; Signal Transduction; Spiro Compounds; Thiophenes	2020
Oliceridine, a G protein-selective ligand at the μ-opioid receptor, for the management of moderate to severe acute pain. Drugs of today (Barcelona, Spain : 1998), 2020, Volume: 56, Issue:4 Topics: Acute Pain; Analgesics, Opioid; GTP-Binding Proteins; Humans; Morphine; Randomized Controlled Trials as Topic; Receptors, Opioid, mu; Spiro Compounds; Thiophenes	2020
Evaluating the Incidence of Opioid-Induced Respiratory Depression Associated with Oliceridine and Morphine as Measured by the Frequency and Average Cumulative Duration of Dosing Interruption in Patients Treated for Acute Postoperative Pain. Clinical drug investigation, 2020, Volume: 40, Issue:8 Topics: Acute Pain; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Female; Humans; Incidence; Male; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Respiratory Insufficiency; Spiro Compounds; Thiophenes	2020
Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America, 2020, 07-14, Volume: 117, Issue:28 Topics: Analgesics, Opioid; Animals; beta-Arrestin 2; Binding Sites; Cell Membrane; Cytoplasm; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Humans; Mice; Molecular Dynamics Simulation; Morphine; Phosphorylation; Protein Binding; Protein Domains; Receptors, Opioid, mu; Signal Transduction; Spiro Compounds; Thiophenes	2020
Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation. International journal of molecular sciences, 2020, Jul-01, Volume: 21, Issue:13 Topics: Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Ligands; Molecular Dynamics Simulation; Morphine; Pain; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Urea	2020
Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine. Anesthesiology, 2020, Volume: 133, Issue:3 Topics: Adult; Analgesics, Opioid; Healthy Volunteers; Humans; Male; Middle Aged; Morphine; Reference Values; Respiratory Insufficiency; Risk Assessment; Spiro Compounds; Thiophenes; Young Adult	2020
Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl-Simulated Interaction Patterns Confronted with Experimental Data. Molecules (Basel, Switzerland), 2020, Oct-12, Volume: 25, Issue:20 Topics: Animals; Fentanyl; Humans; Molecular Dynamics Simulation; Morphine; Receptors, Opioid; Thiophenes; Urea	2020
Low Incidence of Postoperative Respiratory Depression with Oliceridine Compared to Morphine: A Retrospective Chart Analysis. Pain research & management, 2020, Volume: 2020 Topics: Acute Pain; Adolescent; Adult; Analgesics, Opioid; Clinical Trials, Phase III as Topic; Female; Humans; Incidence; Male; Middle Aged; Morphine; Pain Management; Pain, Postoperative; Respiratory Insufficiency; Retrospective Studies; Spiro Compounds; Thiophenes; Young Adult	2020
Oliceridine for the Management of Acute Postoperative Pain. The Annals of pharmacotherapy, 2021, Volume: 55, Issue:10 Topics: Acute Pain; Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Spiro Compounds; Thiophenes	2021
Probing biased activation of mu-opioid receptor by the biased agonist PZM21 using all atom molecular dynamics simulation. Life sciences, 2021, Mar-15, Volume: 269 Topics: Allosteric Regulation; Animals; Aspartic Acid; Cluster Analysis; Conserved Sequence; Crystallization; Humans; Ligands; Mice; Molecular Dynamics Simulation; Morphine; Principal Component Analysis; Protein Conformation; Receptors, Opioid, mu; Signal Transduction; Structural Homology, Protein; Thiophenes; Tyrosine; Urea; Water	2021
TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number. British journal of pharmacology, 2021, Volume: 178, Issue:8 Topics: Analgesics, Opioid; Animals; Cricetinae; Cricetulus; Drug Tolerance; Mice; Mice, Inbred C57BL; Morphine; Receptors, Opioid, mu; Spiro Compounds; Thiophenes	2021
Role of β-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia. European journal of pharmacology, 2021, May-15, Volume: 899 Topics: Analgesics, Opioid; Animals; Behavior, Animal; beta-Arrestin 2; Cells, Cultured; Disease Models, Animal; Drug Tolerance; Female; Ganglia, Spinal; Male; Mice, Knockout; Morphine; Neurons; Nociceptive Pain; Pain Threshold; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Time Factors	2021
CHARMM Force-Field Parameters for Morphine, Heroin, and Oliceridine, and Conformational Dynamics of Opioid Drugs. Journal of chemical information and modeling, 2021, 08-23, Volume: 61, Issue:8 Topics: Analgesics, Opioid; Heroin; Morphine; Pharmaceutical Preparations; Receptors, Opioid, mu; Spiro Compounds; Thiophenes	2021
Preclinical discovery and development of oliceridine (Olinvyk®) for the treatment of post-operative pain. Expert opinion on drug discovery, 2022, Volume: 17, Issue:3 Topics: Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Spiro Compounds; Thiophenes	2022
Budget impact and pharmacy costs with targeted use of oliceridine for postsurgical pain in patients at high risk of opioid-related adverse events. Expert review of pharmacoeconomics & outcomes research, 2022, Volume: 22, Issue:4 Topics: Aged; Analgesics, Opioid; Humans; Morphine; Pain, Postoperative; Pharmacy; Spiro Compounds; Thiophenes	2022
Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation. European journal of medicinal chemistry, 2022, Dec-05, Volume: 243 Topics: Analgesics; Analgesics, Opioid; Constipation; Humans; Morphine; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, mu; Thiophenes	2022