thiophenes has been researched along with me 3277 in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Komiya, I; Okudaira, N; Speirs, GC; Sugiyama, Y; Tatebayashi, T | 1 |
| Komiya, I; Okudaira, N; Sugiyama, Y | 1 |
| Ishiwata, K; Jonker, JW; Kojima, M; Kondo, C; Kusuhara, H; Okudaira, N; Onuki, R; Sugiyama, Y; Suzuki, H; Suzuki, M | 1 |
3 other study(ies) available for thiophenes and me 3277
| Article | Year |
|---|---|
A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug.
Topics: Administration, Oral; Amides; Animals; Biological Availability; Biological Transport, Active; Caco-2 Cells; Cell Membrane Permeability; Humans; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Liver; Male; Mesenteric Veins; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Rats; Thiophenes | 2000 |
Polarized efflux of mono- and diacid metabolites of ME3229, an ester-type prodrug of a glycoprotein IIb/IIIa receptor antagonist, in rat small intestine.
Topics: Amides; Animals; Biological Transport; Caco-2 Cells; Fibrinolytic Agents; Humans; Indicators and Reagents; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Naphthols; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Thiophenes | 2000 |
Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).
Topics: Amides; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Cell Line; Female; Intestinal Absorption; Jejunum; Mice; Mice, Knockout; Perfusion; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Thiophenes; Transport Vesicles | 2005 |