thiophenes has been researched along with leukotriene b4 in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dereu, N; Hilboll, G; Kuhl, P; Labaudinière, R; Lautenschläger, HH; Leon-Lomeli, A; Parnham, M | 1 |
| Cavy, F; Dereu, N; Hilboll, G; Kuhl, P; Labaudinière, R; Leon-Lomeli, A; Parnham, M; Terlain, B | 1 |
| Bach, MK; Brashler, JR; Burdick, MD; Ghazal, NB; Holm, MS; Schaub, RG; Toy, A; White, GJ; Yamashita, A | 1 |
| Hsueh, W; Needleman, P; Spaethe, SM | 1 |
| Arnout, J; Deckmyn, H; Gresele, P; Vermylen, J | 1 |
| Barr, RM; Black, AK; Dowd, PM; Greaves, MW; Isaacs, JL; Koro, O; Mistry, K | 1 |
| Farina, PR; Graham, AG; Gundel, RH; Hattox, SE; Homon, CA; Lazer, ES; Riska, PS; Wegner, CD | 1 |
| Iversen, L; Kragballe, K; Svendsen, M | 1 |
| Ansell, J; Argentieri, DC; Barbone, AG; Beers, SA; Kirchner, T; Malloy, E; Ritchie, DM; Singer, M; Steber, M; Stewart, A; Wachter, MP; Wu, W | 1 |
| Kensler, TW; Primiano, T; Sutter, TR; Trush, MA | 1 |
| Havelková, M; Jandera, A; Kuchar, M; Nic, M; Palecek, J; Panajotová, V; Svoboda, J; Terinek, M | 1 |
| Brady, CS; FitzGerald, MX; Mackarel, AJ; O'Connor, CM; Russell, KJ | 1 |
| Andre, N; Bellot, I; Briss, S; Deschamps, C; Droual, M; Sauveur, F; Tordjman, C; Wierzbicki, M | 1 |
| Bristulf, J; Haeggström, JZ; Karlsson, U; Owman, C; Sabirsh, A | 1 |
| Aquino, M; Bruno, I; Guerrero, MD; Payá, M; Riccio, R; Terencio, MC | 1 |
| Dal Negro, RW; Micheletto, C; Tognella, S; Visconti, M | 1 |
1 trial(s) available for thiophenes and leukotriene b4
| Article | Year |
|---|---|
Erdosteine affects eicosanoid production in COPD.
Topics: Aged; Antioxidants; Double-Blind Method; Eicosanoids; Female; Forced Expiratory Volume; Humans; Leukotriene B4; Leukotriene E4; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Thioglycolates; Thiophenes | 2011 |
15 other study(ies) available for thiophenes and leukotriene b4
| Article | Year |
|---|---|
Omega-[(omega-arylalkyl)aryl]alkanoic acids: a new class of specific LTA4 hydrolase inhibitors.
Topics: Animals; Carboxylic Acids; Drug Stability; Enzyme Inhibitors; Epoxide Hydrolases; Leukocytes; Leukotriene A4; Leukotriene B4; Leukotrienes; Male; Molecular Structure; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Swine; Thiophenes | 1992 |
Omega-[(omega-arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists.
Topics: Animals; Chromatography, High Pressure Liquid; Epoxide Hydrolases; Female; Guinea Pigs; Leukocytes; Leukotriene A4; Leukotriene B4; Leukotrienes; Molecular Structure; Receptors, Immunologic; Receptors, Leukotriene B4; Structure-Activity Relationship; Swine; Thiophenes | 1992 |
1,4-Dihydronaphthoquinones, hydroindoloquinones, benzofurans, and benzothiophenes as inhibitors of 5-lipoxygenase. Synthesis and structure-activity studies.
Topics: Animals; Arachidonate Lipoxygenases; Benzofurans; Chemical Phenomena; Chemistry; Chemistry, Physical; Enzyme Inhibitors; In Vitro Techniques; Indoles; Leukocytes, Mononuclear; Leukotriene B4; Lipoxygenase Inhibitors; Naphthoquinones; Quinones; Rats; SRS-A; Structure-Activity Relationship; Thiophenes | 1990 |
Pharmacological manipulation of inflammation in rabbit hydronephrosis: effects of a combined cyclooxygenase/lipoxygenase inhibitor ethoxyquin, a thromboxane synthase inhibitor RS-5186 and a PAF antagonist L-659,989.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Ethoxyquin; Fatty Acids, Nonesterified; Furans; Hydronephrosis; Inflammation; Kidney; Leukotriene B4; Lipoxygenase Inhibitors; Male; Perfusion; Platelet Activating Factor; Quinolines; Rabbits; Thiophenes; Thromboxane-A Synthase | 1989 |
L-652,343, a novel dual cyclo/lipoxygenase inhibitor, inhibits LTB4-production by stimulated human polymorphonuclear cells but not by stimulated human whole blood.
Topics: Calcimycin; Cyclooxygenase Inhibitors; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Thiophenes; Thromboxane B2 | 1987 |
The in vitro 5-lipoxygenase and cyclo-oxygenase inhibitor L-652,343 does not inhibit 5-lipoxygenase in vivo in human skin.
Topics: Adult; Arachidonate Lipoxygenases; Cyclooxygenase Inhibitors; Dinoprostone; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Psoriasis; Skin; Thiophenes | 1988 |
A prodrug of a 2,6-disubstituted 4-(2-arylethenyl)phenol is a selective and orally active 5-lipoxygenase inhibitor.
Topics: Animals; Antigens; Biological Availability; Calcimycin; Female; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Macaca fascicularis; Male; Phenols; Prodrugs; Saimiri; SRS-A; Thiophenes; Thromboxane B2 | 1993 |
Cyclosporin A down-regulates the LTA4 hydrolase level in human keratinocyte cultures.
Topics: 8,11,14-Eicosatrienoic Acid; Anti-Inflammatory Agents; Antineoplastic Agents; Calcitriol; Cells, Cultured; Cyclosporine; Dexamethasone; Down-Regulation; Epoxide Hydrolases; Humans; Interferon-gamma; Keratinocytes; Leukotriene B4; Methotrexate; Psoriasis; Thiophenes; Tretinoin | 1996 |
Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Evaluation Studies as Topic; Female; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Male; Sulfonamides; Thiophenes | 1997 |
Induction of leukotriene B4 metabolism by cancer chemopreventive agents.
Topics: Alcohol Oxidoreductases; Animals; Antineoplastic Agents; Cytosol; Leukotriene B4; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344; RNA, Messenger; Thiones; Thiophenes | 1999 |
[Substituted benzo[b]thiophenes with anti-leukotriene activity].
Topics: Animals; Cells, Cultured; Edema; Leukotriene Antagonists; Leukotriene B4; Mice; Neutrophils; Rats; Thiophenes | 1999 |
Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.
Topics: CD11 Antigens; CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Humans; Hydroxamic Acids; Interleukin-8; L-Selectin; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Permeability; Phenylalanine; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes | 2000 |
Synthesis of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Calcimycin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Indicators and Reagents; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Mice; Neutrophils; Prostaglandin-Endoperoxide Synthases; Rats; Thiophenes | 2003 |
Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology.
Topics: Acetates; Acrylates; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Benzoates; Calcium Signaling; HeLa Cells; Humans; Indoles; Ionomycin; Leukocytes; Leukotriene Antagonists; Leukotriene B4; Organophosphonates; Polymerase Chain Reaction; Receptors, Leukotriene B4; Thapsigargin; Thiophenes; Transfection | 2005 |
Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression.
Topics: 4-Butyrolactone; Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Behavior, Animal; Blood Platelets; Cattle; Chronic Disease; Gene Expression Regulation, Enzymologic; Humans; Hyperalgesia; Inflammation; Intramolecular Oxidoreductases; Leukotriene B4; Male; Mice; Neutrophils; Prostaglandin-E Synthases; Thiophenes; Thromboxane B2 | 2009 |