thiophenes has been researched along with kr-33028 in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, EY; Cheon, HG; Kim, H; Kim, JH; Lee, HS; Lee, S; Lee, SS; Liu, KH; Shin, JG; Yi, KY; Yoo, SE; Yoon, YJ | 1 |
| Jung, YS; Kim, MJ; Kim, MY; Lee, BH; Lee, S; Oh, KS; Yi, KY; Yoo, SE | 1 |
| Cheon, HG; Kang, S; Kim, H; Liu, KH; Shin, JG; Yoo, SE; Yoon, YJ | 1 |
| Ji, HY; Kim, YH; Kim, YS; Lee, HS; Lee, KH; Lee, S; Yi, KY | 1 |
| Han, W; Jung, YS; Kim, J; Kim, KH; Kim, MY; Lee, BH; Lee, MG; Namkung, W; Yi, KY; Yoo, SE | 1 |
| Lee, BH; Lee, S; Oh, KS; Seo, HW; Yi, KY; Yoo, SE | 1 |
| Kim, YH; Kim, YS; Lee, HS; Lee, KH; Yoo, SD | 1 |
| Baik, EJ; Jung, YS; Kim, YS; Lee, BK; Lee, DH; Lee, KH; Lee, MG; Lee, S; Lee, SH; Moon, CH; Park, S; Park, SL; Yi, KY; Yoo, SE; Yoon, JS | 1 |
8 other study(ies) available for thiophenes and kr-33028
| Article | Year |
|---|---|
In vitro metabolism of a new cardioprotective agent, KR-33028 in the human liver microsomes and cryopreserved human hepatocytes.
Topics: Biotransformation; Cardiotonic Agents; Cryopreservation; Cytochrome P-450 Enzyme System; Glucuronides; Guanidines; Hepatocytes; Humans; Hydroxylation; In Vitro Techniques; Indicators and Reagents; Isoenzymes; Mass Spectrometry; Microsomes, Liver; NADP; Thiophenes | 2005 |
Pharmacological profile of KR-33028, a highly selective inhibitor of Na+/H+ exchanger.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Apoptosis; Behavior, Animal; Binding, Competitive; Calcium; Cardiotonic Agents; Cell Hypoxia; Cell Line; Cytosol; Dose-Response Relationship, Drug; Erythrocyte Count; Female; Glycogen; Guanidines; Heart; Humans; Hydrogen-Ion Concentration; In Situ Nick-End Labeling; Male; Mitochondria; Myocardial Reperfusion Injury; Myocardium; Organ Size; Perfusion; Phosphocreatine; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Sodium-Hydrogen Exchangers; Spleen; Thiophenes | 2006 |
Characterization of the cytochrome P450 enzymes involved in the metabolism of a new cardioprotective agent KR-33028.
Topics: Biotransformation; Cardiotonic Agents; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Guanidines; Humans; Hydroxylation; In Vitro Techniques; Mass Spectrometry; Microsomes, Liver; Thiophenes | 2006 |
Determination of a selective Na+/H+ exchanger inhibitor, 4-cyano(benzo[b]thiophene-2-carbonyl)guanidine (KR-33028) in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Guanidines; Rats; Reference Standards; Sodium-Hydrogen Exchangers; Tandem Mass Spectrometry; Thiophenes | 2007 |
Pharmacodynamic characteristics and cardioprotective effects of new NHE1 inhibitors.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Hypoxia; Cell Survival; Cells, Cultured; Furans; Guanidines; Humans; Kinetics; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Structure-Activity Relationship; Submandibular Gland; Sulfones; Thiophenes | 2007 |
Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on ischemia and reperfusion-induced myocardial infarction in rats and dogs.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Pressure; Cardiotonic Agents; Creatine Kinase; Dogs; Guanidines; Heart Rate; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Thiophenes; Troponin I | 2007 |
Dose-dependent pharmacokinetics of a new Na+/H+ exchanger inhibitor KR-33028 in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guanidines; Half-Life; Humans; Injections, Intravenous; Male; Mass Spectrometry; Protein Binding; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Thiophenes | 2007 |
Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct.
Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Cells, Cultured; Cerebral Cortex; Cerebral Infarction; Enzyme Activation; Glutamic Acid; Guanidines; In Situ Nick-End Labeling; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Necrosis; Neurons; Neuroprotective Agents; Pyrazoles; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Thiophenes | 2009 |