Page last updated: 2024-08-18

thiophenes and indomethacin

thiophenes has been researched along with indomethacin in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (30.43)	18.7374
1990's	15 (32.61)	18.2507
2000's	11 (23.91)	29.6817
2010's	5 (10.87)	24.3611
2020's	1 (2.17)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Van Nueten, JM	1
Boneu-Valmalette, A; Bugat, R; Combes, PF; David, JF	1
Ferber, RH; Parrish, SL; Vigdahl, RL	1
Janssen, PA; Niemegeers, CJ; Van Bruggen, JA	1
Awouters, F; Janssen, PA; Lenaerts, PM; Niemegeers, CJ	1
Janssen, PA; Niemegeers, CJ	1
Awouters, F; Janssen, PA; Lenaerts, FM; Niemegeers, CJ	3
Janssen, PA; Lenaerts, FM; Niemegeers, CJ	1
Barthelmebs, M; Decker, N; Imbs, JL; Krieger, JP; Rochat, C; Stephan, D	1
Gavalas, A; Kourounakis, L; Kourounakis, P; Litina, D	1
Ikegami, K; Imamura, H; Nakanishi, M	1
Kobayakawa, T	1
Alpermann, HG	1
Thornton, EJ; Walter, J; Wojtulewski, J	1
Conroy, MC; Finkel, M; Grabow, D; Lesch, M; Low, J; Metz, A; Schrier, D; Sommers, C; Wallace, J	1
Arányi, P; Erdö, F; Németh, K; Székely, JI; Török, K	1
Creely, DP; Gierse, JK; Hauser, SD; Isakson, PC; Koboldt, C; Rangwala, SH; Seibert, K	1
Crimmin, MJ; DiMartino, MJ; Galloway, WA; High, W	1
Sasaki, T; Satoh, M; Shimura, S; Shirato, K; Takishima, T; Yamada, K	1
Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Terada, A; Yamaguchi, T	1
Hisamoto, M; Ikeda, T; Itoh, K; Matsuda, K; Mukaiyama, O; Satoh, Y; Yamaguchi, T; Yamamura, N	1
Gao, XP; Olopade, CO; Rubinstein, I; Suzuki, H	1
Ekabo, O; Garavito, RM; Loll, PJ; Picot, D	1
Ballhausen, T; Rösen, P; Stockklauser, K	1
Konishi, N; Matsuo, M; Nakamura, K; Ochi, T; Senoh, H; Tojo, T; Tsuji, K	1
Chapman, K; McKnight, W; Wallace, JL	1
Danon, A; Rimon, G; Rosenstock, M	1
Dannhardt, G; Fiebich, B; Kiefer, W; Krämer, G; Maehrlein, S; Nowe, U	1
Barnett, K; Bell, CJ; Dicay, M; McKnight, W; Sharkey, KA; Wallace, JL	1
Danon, A; Rimon, G; Rosenstock, M; Rubin, M	1
Barreiro, EJ; Noël, F; Silva, CL	1
Izon, DJ; Loftin, C; Spain, LM; Xu, H	1
Baydoun, AR; Churchman, A; Hoffman, R	1
Cicha, MZ; Hökfelt, T; Kopp, UC; Mulder, J; Smith, LA	1
El-Gazzar, AB; Hafez, HN	1
Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT	1
Bäck, M; Brink, C; Foudi, N; Louedec, L; Michel, JB; Norel, X; Rienzo, M	1
Higuchi, K; Inoue, T; Ishida, K; Jin, D; Kakimoto, K; Murano, M; Takai, S; Umegaki, E; Yoda, Y	1
Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O	1
Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ	1
Cao, H; Chen, X; Guan, S; He, B; Li, Y; Shi, C; Wang, J; Xu, X; Zhang, S	1
Brouwers, S; Dupont, AG; Massie, A; Smolders, I	1
El-Nassan, HB; Fahim, SH; Mahmoud, ST; Mikhail, DS	1

Trials

1 trial(s) available for thiophenes and indomethacin

Article	Year
Tiaprofenic acid (surgam) in the treatment of osteoarthritis of the knee and hip. Rheumatology and rehabilitation, 1981, Volume: 20, Issue:3 Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Hip Joint; Humans; Indomethacin; Knee Joint; Middle Aged; Osteoarthritis; Propionates; Random Allocation; Thiophenes	1981

Other Studies

45 other study(ies) available for thiophenes and indomethacin

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
Antagonism of arachidonic acid hydroperoxide on isolated gastrointestinal tissues as a measure of the inhibition of prostaglandin biosynthesis. Advances in prostaglandin and thromboxane research, 1976, Volume: 1 Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Biological Assay; Bradykinin; Depression, Chemical; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Peroxides; Phenylbutazone; Phenylpropionates; Prostaglandin Antagonists; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Serotonin Antagonists; Thiophenes	1976
[Kinetics of I-131 fibrinogen in cancer patients: pharmacological approach]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1977, Volume: 171, Issue:6 Topics: Aspirin; Blood Coagulation; Fibrinogen; Fibrinolytic Agents; Heparin; Indomethacin; Iodine Radioisotopes; Kinetics; Neoplasms; Platelet Aggregation; Prednisone; Pyridines; Thiophenes	1977
Evaluation of antiinflammatory and antithrombotic drugs in pulmonary and arterial thrombosis. Thrombosis research, 1979, Volume: 16, Issue:1-2 Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Anti-Inflammatory Agents; Arterial Occlusive Diseases; Aspirin; Benzophenones; Carotid Arteries; Cattle; Dipyridamole; Drug Evaluation; Fibrinolytic Agents; Humans; Imidazoles; Indoles; Indomethacin; Lung Diseases, Obstructive; Male; Mice; Platelet Aggregation; Prostaglandins; Pyridines; Quinazolines; Rats; Sulfinpyrazone; Sulfonamides; Suloctidil; Thiophenes	1979
Suprofen, a potent antagonist of acetic acid-induced writhing in rats. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Acetates; Analgesics; Animals; Arachidonic Acids; Aspirin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indomethacin; Ketoprofen; Male; Muscle Contraction; Phenylacetates; Phenylbutazone; Phenylpropionates; Prostaglandin Antagonists; Prostaglandins; Rats; Spasm; Thiophenes; Tolmetin	1975
Suprofen, a potent antagonist of ultraviolet-erythema in guinea-pigs. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythema; Guinea Pigs; Indomethacin; Ketoprofen; Male; Phenylbutazone; Phenylpropionates; Thiophenes; Time Factors; Tolmetin; Ultraviolet Rays	1975
Suprofen, a potent antagonist of sodium urate crystal-induced arthritis in dogs. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indomethacin; Knee Joint; Male; Phenylbutazone; Phenylpropionates; Thiophenes; Time Factors; Uric Acid	1975
The activity of suprofen on nystatin-induced paw oedema in rats. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Edema; Hindlimb; Indomethacin; Male; Nystatin; Phenylbutazone; Phenylpropionates; Rats; Thiophenes; Time Factors	1975
The antipyretic effect of suprofen in rats with yeast-induced fever. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Analgesics; Animals; Aspirin; Body Temperature; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fever; Indomethacin; Male; Phenylbutazone; Phenylpropionates; Rats; Thiophenes; Time Factors; Tolmetin; Yeast, Dried	1975
The effects of suprofen in rats with Mycobacterium butyricum-induced arthritis. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Biometry; Body Weight; Bone and Bones; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Haptoglobins; Hindlimb; Indomethacin; Phenylbutazone; Phenylpropionates; Rats; Tarsal Joints; Thiophenes; Tolmetin	1975
Gastrointestinal effects and acute toxicity of suprofen. Arzneimittel-Forschung, 1975, Volume: 25, Issue:10 Topics: Animals; Antidiarrheals; Aspirin; Digestive System; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eating; Female; Guinea Pigs; Indomethacin; Ketoprofen; Lethal Dose 50; Male; Mice; Phenylacetates; Phenylpropionates; Rats; Rats, Inbred Strains; Thiophenes; Time Factors; Ulcer	1975
Effect of tertatolol and of its metabolites and structural analogues in isolated perfused rat kidney vasculature. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:2 Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Aorta, Thoracic; Benzazepines; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth, Vascular; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Renal Circulation; Serotonin; Thiophenes; Vasoconstrictor Agents	1990
Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 1st communication: inhibitory effects on mouse paw edema. Arzneimittel-Forschung, 1991, Volume: 41, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Concanavalin A; Edema; Female; Foot; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mustard Plant; Nystatin; Plant Lectins; Plants, Medicinal; Thiophenes; Yeasts	1991
[Studies on anti-inflammatory agents. XVII. Effects of 2-amino-3-ethoyxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine (Y-3642) hydrochoride on oxidative phosphorylation, swelling and adenosine triphosphatase of rat liver mitochondria]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1971, Volume: 91, Issue:7 Topics: Adenosine Triphosphatases; Animals; Anti-Inflammatory Agents; Aspirin; Depression, Chemical; In Vitro Techniques; Indomethacin; Male; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Phosphorylation; Phenylacetates; Phenylbutazone; Pyridines; Rats; Stimulation, Chemical; Thiophenes	1971
[Experimental study on drugs for the treatment of myocardial infarction]. Japanese circulation journal, 1972, Volume: 36, Issue:1 Topics: Angiography; Animals; Benzyl Compounds; Body Weight; Carboxylic Acids; Dipyridamole; Disease Models, Animal; Electrocardiography; Glycols; Hydrocortisone; Indomethacin; Isoproterenol; Male; Microradiography; Microscopy, Electron; Myocardial Infarction; Myocardium; Organ Size; Phenoxybenzamine; Phenylbutazone; Propranolol; Pyridines; Rats; Rats, Inbred Strains; Thiophenes	1972
[Delay of UV-erythema by thiophencarbonic acid derivatives]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:2 Topics: Acids; Animals; Anti-Inflammatory Agents; Depression, Chemical; Erythema; Flufenamic Acid; Guinea Pigs; Indomethacin; Phenylbutazone; Radiation-Protective Agents; Thiophenes; Ultraviolet Rays	1970
Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion. Gastroenterology, 1995, Volume: 109, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Adhesion; Dinoprostone; Dogs; Ethanol; Female; Gastric Acid; Gastric Mucosa; Histamine Antagonists; Indomethacin; Leukocytes; Leukotriene C4; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfhydryl Compounds; Tetrazoles; Thiophenes	1995
Measurement and drug induced modulation of interleukin-1 level during zymosan peritonitis in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:6 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Indomethacin; Interleukin-1; Male; Mice; Peritonitis; Thiophenes; Zymosan	1995
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. The Biochemical journal, 1995, Jan-15, Volume: 305 ( Pt 2) Topics: Animals; Arachidonic Acid; Baculoviridae; Cloning, Molecular; Cyclooxygenase Inhibitors; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Indomethacin; Nitrobenzenes; Oxygen Consumption; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Spodoptera; Sulfonamides; Thiophenes; Time Factors	1995
Preclinical antiarthritic activity of matrix metalloproteinase inhibitors. Annals of the New York Academy of Sciences, 1994, Sep-06, Volume: 732 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Indomethacin; Inflammation; Isomerism; Metalloendopeptidases; Phenylalanine; Radiography; Rats; Thiophenes; Time Factors	1994
An expectorant, stepronin, reduces airway secretion in vitro. Respiration; international review of thoracic diseases, 1994, Volume: 61, Issue:1 Topics: Amiloride; Animals; Cats; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Epithelium; Expectorants; Female; Glycine; Indomethacin; Isoproterenol; Male; Membrane Potentials; Mucus; Structure-Activity Relationship; Sulfides; Thiophenes; Trachea	1994
Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response. European journal of pharmacology, 1993, May-12, Volume: 236, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Chlorpheniramine; Disease Models, Animal; Guinea Pigs; Indomethacin; Male; Methacrylates; Ovalbumin; Propranolol; Prostaglandin Endoperoxides, Synthetic; SRS-A; Thiophenes; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents	1993
Alteration of eicosanoid production in the sensitized guinea pig lung by CS-518. European journal of pharmacology, 1993, Jun-24, Volume: 237, Issue:2-3 Topics: Administration, Oral; Animals; Arachidonic Acid; Eicosanoids; Guinea Pigs; Histamine; Indomethacin; Lung; Male; Ovalbumin; Prostaglandins; Radioimmunoassay; SRS-A; Thiophenes; Thromboxane A2; Thromboxane-A Synthase; Vaccination	1993
Short-term exposure to lipopolysaccharide is associated with microvascular contractile dysfunction in vivo. Life sciences, 1995, Mar-03, Volume: 56, Issue:15 Topics: Acrylates; Allopurinol; Animals; Antihypertensive Agents; Arginine; Arterioles; Cheek; Cricetinae; Imidazoles; Indomethacin; Lipopolysaccharides; Male; Mesocricetus; Nitroarginine; Thiophenes; Vasoconstriction; Vasodilation	1995
Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site. Biochemistry, 1996, Jun-11, Volume: 35, Issue:23 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Crystallography, X-Ray; Cyclooxygenase Inhibitors; Flurbiprofen; Indomethacin; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Protein Structure, Secondary; Thiophenes	1996
Impairment of endothelium dependent relaxation in the diabetic rat heart: mechanisms and implications. Diabetes research and clinical practice, 1996, Volume: 31 Suppl Topics: Animals; Antioxidants; Coronary Circulation; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glycosylation; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Perfusion; Piperazines; Rats; Rats, Wistar; Superoxide Dismutase; Thiophenes; Vasodilation; Vitamin E	1996
Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives. Chemical & pharmaceutical bulletin, 1997, Volume: 45, Issue:6 Topics: Anilides; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Indomethacin; Male; Models, Chemical; Models, Molecular; Pyrazoles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes	1997
Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation. British journal of pharmacology, 1999, Volume: 126, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Interactions; Indomethacin; Inflammation; Isoenzymes; Leukocytes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Thiophenes	1999
PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Biochimica et biophysica acta, 1999, Aug-25, Volume: 1440, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fibroblasts; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Sulfonamides; Thiophenes	1999
The pyrrole moiety as a template for COX-1/COX-2 inhibitors. European journal of medicinal chemistry, 2000, Volume: 35, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Isoenzymes; Leukocytes, Mononuclear; Membrane Proteins; Molecular Structure; Monocytes; Neutrophils; Prostaglandin-Endoperoxide Synthases; Pyrroles; Sulfones; Thiophenes	2000
Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach. American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Gastritis; Indomethacin; Iodoacetamide; Isoenzymes; Male; Pentagastrin; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Thiophenes	2000
Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs. European journal of pharmacology, 2001, Jan-19, Volume: 412, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Ibuprofen; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sulfonamides; Thiophenes	2001
Cyclic GMP-dependent vasodilatory properties of LASSBio 294 in rat aorta. British journal of pharmacology, 2002, Volume: 135, Issue:1 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Hydrazones; In Vitro Techniques; Indomethacin; Male; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Thiophenes; Vasoconstriction; Vasodilator Agents	2002
The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition. Cellular immunology, 2001, Dec-15, Volume: 214, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Immunologic Deficiency Syndromes; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Nitrobenzenes; Organ Culture Techniques; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Sulfonamides; T-Lymphocytes; Thiophenes; Thymus Gland	2001
Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697). European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3 Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase Inhibitors; Cells, Cultured; Chromatin Assembly and Disassembly; Collagen; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Endothelial Cells; Flow Cytometry; Humans; Indomethacin; Laminin; Neovascularization, Physiologic; Oligopeptides; Proteoglycans; Thiophenes; Vascular Endothelial Growth Factor A	2007
Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers. American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:4 Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Fibers; Animals; Calcitonin Gene-Related Peptide; Dinoprostone; Indomethacin; Kidney; Male; Neurons, Afferent; Neurons, Efferent; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Substance P; Thiophenes; Triazoles	2007
Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d]pyrimidines as new bioactive and pharmacological activities. Bioorganic & medicinal chemistry letters, 2008, Oct-01, Volume: 18, Issue:19 Topics: Alternaria; Analgesics; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bacillus cereus; Fusarium; Indomethacin; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; Salmonella typhi; Structure-Activity Relationship; Thiophenes	2008
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. Brain research, 2009, Oct-27, Volume: 1295 Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Edema; Freund's Adjuvant; Gabapentin; Gait; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Male; Morphine; Neuralgia; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Thiophenes	2009
Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cholesterol; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Epoprostenol; Hypercholesterolemia; Indomethacin; Male; Norepinephrine; Rabbits; Thiophenes; Vasoconstriction; Vasoconstrictor Agents	2009
Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chymases; Enteritis; Enzyme Inhibitors; Indomethacin; Intestine, Small; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Peroxidase; Phenyl Ethers; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Time Factors	2010
Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model. Behavioural pharmacology, 2011, Volume: 22, Issue:5-6 Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Indomethacin; Male; Milnacipran; Rats; Rats, Wistar; Thiophenes	2011
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. European journal of pharmacology, 2012, Sep-15, Volume: 691, Issue:1-3 Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine Hydrochloride; Fluoxetine; Immersion; Indomethacin; Male; Mianserin; Mirtazapine; Rats; Rats, Sprague-Dawley; Reserpine; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Thiophenes; Water	2012
Cyclooxygenase-2 regulated by the nuclear factor-κB pathway plays an important role in endometrial breakdown in a female mouse menstrual-like model. Endocrinology, 2013, Volume: 154, Issue:8 Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Decidua; Endometrium; Female; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Indomethacin; Leupeptins; Menstruation; Mice; Mice, Inbred C57BL; Models, Animal; NF-kappa B; Promoter Regions, Genetic; Protein Binding; Pyrrolidines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Thiophenes	2013
Angiotensin II type 2 receptor-mediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 62, Issue:5 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Captopril; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fenoldopam; Imidazoles; Indomethacin; Kidney; Nitric Oxide; omega-N-Methylarginine; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Sulfonamides; Thiophenes; Vasodilation; Vasodilator Agents	2013
Nonacidic thiophene-based derivatives as potential analgesic and design, synthesis, biological evaluation, and metabolic stability study. Drug development research, 2022, Volume: 83, Issue:8 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chromatography, Liquid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Humans; Indomethacin; Rats; Tandem Mass Spectrometry; Thiophenes	2022