thiophenes has been researched along with indiplon in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 24 (77.42) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ballew, N | 1 |
| Bozigian, HP; Chen, TK; Cullen, MJ; Foster, AC; Gogas, KR; Gross, RS; Joppa, M; Lewis, D; Pelleymounter, MA | 1 |
| Foster, AC; Grigoriadis, DE; Gross, RS; Petroski, RE; Sullivan, SK; Verge, G | 1 |
| Borrell, JI; Buira, I; Falcó, JL; Guglietta, A; Lloveras, M; Méndez, E; Palomer, A; Teixidó, J; Terencio, J | 1 |
| Neubauer, DN | 1 |
| Bowman, H; Chen, AP; Das, R; Foster, AC; Petroski, RE; Pomeroy, JE; Yang, W | 1 |
| Gammack, JK; Kamel, NS | 1 |
| Miyamoto, M; Terao, A | 1 |
| Ancoli-Israel, S; Lankford, A | 1 |
| Carter, LP; Casada, JH; Griffiths, RR; Roache, JD; Suess, PE; Wallace, CL | 1 |
| Farber, R; Landin, R; Lankford, DA; Lydiard, RB; Seiden, DJ; Walsh, JK | 1 |
| Black, J; Farber, R; Hull, S; Landin, R; Scharf, MB | 1 |
| Brust, P; Deuther-Conrad, W; Diekers, M; Fischer, S; Hiller, A; Hoepping, A; Scheunemann, M; Steinbach, J; Wegner, F | 1 |
| Bozigian, HP; Chapman, D; Fisher, A; Jin, L; Madan, A | 1 |
| Park, A | 1 |
| Farber, R; Lankford, DA; Rosenberg, R; Roth, T; Scharf, MB | 1 |
| Burke, J; Farber, R; Moscovitch, A; Roth, T; Walsh, JK | 1 |
| Allgaier, C; Brust, P; Deuther-Conrad, W; Diekers, M; Fischer, S; Hiller, A; Hoepping, A; Scheunemann, M; Steinbach, J; Strecker, K; Wegner, F; Wohlfarth, K | 1 |
| Farber, R; Roth, T; Scharf, MB; Zammit, GK | 1 |
| Burke, PJ; Farber, RH | 1 |
| Hutson, PH; McDonald, LM; Sheppard, WF; Sohal, B; Staveley, SM; Tattersall, FD | 1 |
| Marrs, JC | 1 |
| Huang, R; Liu, Y; Wang, J; Xiao, B; Xu, L; Yang, J | 1 |
| Caballero, A; Cass, DK; Thomases, DR; Tseng, KY | 1 |
| Fukami, T; Ito, Y; Kariya, M; Kurokawa, T; Nakajima, M; Shimizu, M; Yokoi, T | 1 |
| Caballero, A; Cass, DK; Flores-Barrera, E; Thomases, DR; Tseng, KY; Vital, WF | 1 |
| Caballero, A; Cass, DK; Meyer, JD; Thomases, DR; Tseng, KY | 1 |
| Arckens, L; Hofman, I; Hu, TT; Laramée, ME; Nys, J; Smolders, K | 1 |
| Alarcón, M; Burgos, CF; Fuentes, E; Palomo, I; Sanchéz, C; Sepúlveda, C | 1 |
4 review(s) available for thiophenes and indiplon
| Article | Year |
|---|---|
Indiplon: the development of a new hypnotic.
Topics: Animals; Benzodiazepines; Drugs, Investigational; Humans; Hypnotics and Sedatives; Sleep Initiation and Maintenance Disorders; Thiophenes | 2005 |
Insomnia in the elderly: cause, approach, and treatment.
Topics: Acetamides; Aged; Aging; Antidepressive Agents; Azabicyclo Compounds; Behavior Therapy; Benzodiazepines; Humans; Hypnotics and Sedatives; Nonprescription Drugs; Piperazines; Pyridines; Pyrimidines; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Thiophenes; Trazodone; Zolpidem | 2006 |
[Recent and potential drugs for treatment of insomnia].
Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Diphenhydramine; Drug Design; Fluorobenzenes; GABA-A Receptor Agonists; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Indenes; Orexin Receptors; Phenols; Piperazines; Pyridines; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Serotonin 5-HT2 Receptor Antagonists; Sleep Initiation and Maintenance Disorders; Thiophenes; Zolpidem | 2007 |
Indiplon: the development of a novel therapy for the treatment of sleep onset and sleep maintenance insomnia.
Topics: Adult; Benzodiazepines; Delayed-Action Preparations; Drug Interactions; Female; Humans; Hypnotics and Sedatives; Male; Sleep Initiation and Maintenance Disorders; Thiophenes; Treatment Outcome | 2007 |
7 trial(s) available for thiophenes and indiplon
| Article | Year |
|---|---|
Relative abuse liability of indiplon and triazolam in humans: a comparison of psychomotor, subjective, and cognitive effects.
Topics: Adult; Behavior; Benzodiazepines; Cognition; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedatives; Male; Mental Recall; Middle Aged; Psychomotor Performance; Reinforcement, Psychology; Single-Blind Method; Substance-Related Disorders; Surveys and Questionnaires; Thiophenes; Triazolam | 2007 |
Efficacy and tolerability of modified-release indiplon in elderly patients with chronic insomnia: results of a 2-week double-blind, placebo-controlled trial.
Topics: Aged; Benzodiazepines; Chronic Disease; Delayed-Action Preparations; Double-Blind Method; Drug Tolerance; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Sleep Initiation and Maintenance Disorders; Thiophenes | 2006 |
Long-term nightly treatment with indiplon in adults with primary insomnia: results of a double-blind, placebo-controlled, 3-month study.
Topics: Adult; Benzodiazepines; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Polysomnography; Severity of Illness Index; Sleep Initiation and Maintenance Disorders; Thiophenes; Time Factors | 2007 |
Efficacy and tolerability of indiplon in transient insomnia.
Topics: Adult; Analysis of Variance; Benzodiazepines; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Polysomnography; Reference Values; Self Disclosure; Sleep Initiation and Maintenance Disorders; Thiophenes; Time Factors; Treatment Outcome | 2007 |
Efficacy and tolerability of indiplon in older adults with primary insomnia.
Topics: Aged; Aged, 80 and over; Benzodiazepines; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Female; Humans; Hypnotics and Sedatives; Male; Single-Blind Method; Sleep Initiation and Maintenance Disorders; Thiophenes; Treatment Outcome | 2007 |
Efficacy and safety of as-needed, post bedtime dosing with indiplon in insomnia patients with chronic difficulty maintaining sleep.
Topics: Adolescent; Adult; Attention; Benzodiazepines; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pain Measurement; Patient Satisfaction; Sleep Initiation and Maintenance Disorders; Thiophenes; Treatment Outcome; Wakefulness | 2007 |
Post-bedtime dosing with indiplon in adults and the elderly: results from two placebo-controlled, active comparator crossover studies in healthy volunteers.
Topics: Adult; Aged; Aged, 80 and over; Azabicyclo Compounds; Benzodiazepines; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pain Measurement; Piperazines; Psychological Tests; Psychometrics; Pyridines; Reference Values; Sleep Initiation and Maintenance Disorders; Thiophenes; Time Factors; Zolpidem | 2008 |
20 other study(ies) available for thiophenes and indiplon
| Article | Year |
|---|---|
Indiplon. Indiplon modified-release, indiplon MR, NBI 34060, NBI 34060 modified-release, NBI 34060 MR.
Topics: Benzodiazepines; Clinical Trials as Topic; Delayed-Action Preparations; Drug Industry; Hypnotics and Sedatives; Sleep Initiation and Maintenance Disorders; Thiophenes | 2002 |
Neurocrine Biosciences, Inc. Soporific science.
Topics: Benzodiazepines; Central Nervous System; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Hypnotics and Sedatives; Sleep Initiation and Maintenance Disorders; Thiophenes | 2003 |
In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic.
Topics: Animals; Avoidance Learning; Benzodiazepines; Male; Mice; Motor Activity; Psychomotor Performance; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiophenes | 2004 |
Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor.
Topics: Acetamides; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Kinetics; Male; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiophenes; Triazolam; Tritium; Zolpidem | 2004 |
Sleeping pills without regrets. They've long been the risky quick fixes of sleep medicine. Soon some sleeping pills may be sold as long-term solutions.
Topics: Acetamides; Age Factors; Azabicyclo Compounds; Benzodiazepines; Humans; Hypnotics and Sedatives; Piperazines; Pyridines; Pyrimidines; Sleep Wake Disorders; Thiophenes; Trazodone; Zolpidem | 2004 |
Design, synthesis and biological activity of acyl substituted 3-amino-5-methyl-1,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones as potential hypnotic drugs.
Topics: Animals; Benzodiazepines; Drug Design; Hypnotics and Sedatives; Male; Pyrazoles; Pyridines; Pyridones; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Thiophenes; Zolpidem | 2005 |
Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors.
Topics: Allosteric Regulation; Animals; Astrocytes; Benzodiazepines; Binding, Competitive; Cell Line; Cloning, Molecular; Dose-Response Relationship, Drug; Humans; Hypnotics and Sedatives; Molecular Structure; Neurons; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Proteins; Thiophenes | 2006 |
Radiosynthesis and biological evaluation of an 18F-labeled derivative of the novel pyrazolopyrimidine sedative-hypnotic agent indiplon.
Topics: Animals; Benzodiazepines; Brain; Drug Evaluation, Preclinical; Drug Stability; Female; Fluorine Radioisotopes; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Isotope Labeling; Metabolic Clearance Rate; Mice; Organ Specificity; Radionuclide Imaging; Thiophenes; Tissue Distribution | 2007 |
In vitro metabolism of indiplon and an assessment of its drug interaction potential.
Topics: Benzodiazepines; Carboxylic Ester Hydrolases; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Humans; Hypnotics and Sedatives; Microsomes, Liver; Thiophenes | 2007 |
The new cancer fighter (and other hot drugs on the way).
Topics: Benzodiazepines; Drug Industry; Drugs, Investigational; Herpes Zoster Vaccine; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; Humans; Insulin; Molecular Biology; Papillomavirus Vaccines; Pharmacogenetics; Piperidines; Pyrazoles; Rimonabant; Thiophenes | 2006 |
GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon.
Topics: Animals; Animals, Newborn; Benzodiazepines; Binding Sites; Electrophysiology; Fluorine Compounds; Fluorine Radioisotopes; Humans; Hypnotics and Sedatives; Ligands; Patch-Clamp Techniques; Positron-Emission Tomography; Radioligand Assay; Rats; Receptors, GABA-A; Structure-Activity Relationship; Thiophenes | 2008 |
Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.
Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Azabicyclo Compounds; Baclofen; Benzodiazepines; Bicuculline; Brain; Cyclohexanecarboxylic Acids; Discrimination Learning; Dose-Response Relationship, Drug; GABA Agents; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Generalization, Stimulus; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoxazoles; Male; Nipecotic Acids; Piperazines; Pyridines; Rats; Thiophenes; Tiagabine; Zolpidem | 2008 |
Indiplon: a nonbenzodiazepine sedative-hypnotic for the treatment of insomnia.
Topics: Adult; Aged; Animals; Benzodiazepines; Humans; Hypnotics and Sedatives; Receptors, GABA-A; Sleep; Sleep Initiation and Maintenance Disorders; Thiophenes | 2008 |
Preparation and characterization of a novel polymorph of indiplon, Form α.
Topics: Benzodiazepines; Calorimetry, Differential Scanning; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Powder Diffraction; Solubility; Spectrum Analysis, Raman; Thermodynamics; Thermogravimetry; Thiophenes | 2012 |
Developmental disruption of gamma-aminobutyric acid function in the medial prefrontal cortex by noncontingent cocaine exposure during early adolescence.
Topics: Age Factors; Animals; Benzodiazepines; Cocaine; GABA Antagonists; GABA Modulators; GABAergic Neurons; Hippocampus; Male; Neural Inhibition; Neural Pathways; Picrotoxin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiophenes | 2013 |
Indiplon is hydrolyzed by arylacetamide deacetylase in human liver.
Topics: Adult; Animals; Benzodiazepines; Biotransformation; Carboxylesterase; Carboxylic Ester Hydrolases; Chlorocebus aethiops; COS Cells; Cytosol; Female; Humans; Hydrolysis; Hypnotics and Sedatives; Male; Microsomes, Liver; Middle Aged; Polymorphism, Genetic; Substrate Specificity; Thiophenes; Young Adult | 2014 |
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex.
Topics: Animals; Benzodiazepines; Benzoxazines; Central Nervous System Agents; Electric Stimulation; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Synaptic Transmission; Thiophenes | 2014 |
Early adolescent MK-801 exposure impairs the maturation of ventral hippocampal control of basolateral amygdala drive in the adult prefrontal cortex.
Topics: Age Factors; Amygdala; Animals; Benzodiazepines; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Interneurons; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Neurons, Afferent; Picrotoxin; Prefrontal Cortex; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Thiophenes; Up-Regulation | 2014 |
Regional Specificity of GABAergic Regulation of Cross-Modal Plasticity in Mouse Visual Cortex after Unilateral Enucleation.
Topics: Animals; Benzodiazepines; Early Growth Response Protein 1; Eye Enucleation; Female; GABA Modulators; Male; Mice; Neuronal Plasticity; Photic Stimulation; Receptors, GABA; Sensory Deprivation; Synaptic Transmission; Thiophenes; Visual Cortex | 2015 |
Anti-aggregation effect on platelets of Indiplon a hypnotic sedative non-benzodiazepine drug.
Topics: Adenosine A2 Receptor Agonists; Adult; Benzodiazepines; Blood Platelets; Dose-Response Relationship, Drug; Humans; Hypnotics and Sedatives; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding; Protein Structure, Secondary; Receptor, Adenosine A2A; Thiophenes; Young Adult | 2019 |