Page last updated: 2024-08-18

thiophenes and ibodutant

thiophenes has been researched along with ibodutant in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (27.27)	29.6817
2010's	7 (63.64)	24.3611
2020's	1 (9.09)	2.80

Authors

Authors	Studies
Altamura, M; Catalani, C; Catalioto, RM; Cialdai, C; Giuliani, S; Lecci, A; Maggi, CA; Meini, S; Patacchini, R; Tramontana, M; Valenti, C	1
Altamura, M; Catalioto, RM; Fedi, V; Giannotti, D; Giolitti, A; Giuliani, S; Guidi, A; Harmat, NJ; Lecci, A; Maggi, CA; Meini, S; Nannicini, R; Pasqui, F; Tramontana, M; Triolo, A	1
Bellucci, F; Catalani, C; Cucchi, P; Giolitti, A; Giuliani, S; Meini, S; Santicioli, P	1
Altamura, M; Dimoulas, T; Fedi, V; Gensini, M; Giannotti, D; Giuliani, S; Guidi, A; Harmat, NJ; Maggi, CA; Meini, S; Nannicini, R; Pasqui, F; Tramontana, M; Triolo, A	1
Bechi, P; Cipriani, G; Evangelista, S; Faussone-Pellegrini, MS; Maggi, CA; Riccadonna, S; Ringressi, MN; Santicioli, P; Vannucchi, MG	1
Bechi, P; Catalani, C; Giuliani, S; Maggi, CA; Meini, S; Riccadonna, S; Ringressi, MN; Santicioli, P	1
Giuliani, S; Lecci, A; Maggi, CA; Meini, S; Santicioli, P	1
Bellucci, F; Buéno, L; Bugianesi, R; Crea, A; D'Aranno, V; Maggi, CA; Meini, S; Santicioli, P; Tramontana, M	1
Capriati, A; Maggi, CA; Scartoni, S; Schumacher, K; Tack, J; Tonini, G	1
Boeckxstaens, G; Camilleri, M	1
Drimousis, S; Liu, L; Markus, I; Murphy, TV; Perera, DS; Phan-Thien, KC; Zhang, L	1

Reviews

1 review(s) available for thiophenes and ibodutant

Article	Year
Dietary and pharmacological treatment of abdominal pain in IBS. Gut, 2017, Volume: 66, Issue:5 Topics: Abdominal Pain; Anti-Infective Agents; Antidepressive Agents; Butyrophenones; Dipeptides; GABA Agents; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Imidazoles; Irritable Bowel Syndrome; Mentha piperita; Parasympatholytics; Phenylalanine; Piperidines; Plant Oils; Probiotics; Quaternary Ammonium Compounds; Rifamycins; Rifaximin; Serotonin 5-HT3 Receptor Antagonists; Thiophenes; Visceral Pain	2017

Article

Year

Dietary and pharmacological treatment of abdominal pain in IBS.

Gut, 2017, Volume: 66, Issue:5

Topics: Abdominal Pain; Anti-Infective Agents; Antidepressive Agents; Butyrophenones; Dipeptides; GABA Agents; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Imidazoles; Irritable Bowel Syndrome; Mentha piperita; Parasympatholytics; Phenylalanine; Piperidines; Plant Oils; Probiotics; Quaternary Ammonium Compounds; Rifamycins; Rifaximin; Serotonin 5-HT3 Receptor Antagonists; Thiophenes; Visceral Pain

2017

Trials

1 trial(s) available for thiophenes and ibodutant

Article	Year
The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS. Gut, 2017, Volume: 66, Issue:8 Topics: Abdominal Pain; Adolescent; Adult; Aged; Diarrhea; Dipeptides; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gastrointestinal Agents; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Quality of Life; Receptors, Neurokinin-2; Sex Factors; Symptom Assessment; Thiophenes; Young Adult	2017

Article

Year

The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS.

Gut, 2017, Volume: 66, Issue:8

Topics: Abdominal Pain; Adolescent; Adult; Aged; Diarrhea; Dipeptides; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gastrointestinal Agents; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Quality of Life; Receptors, Neurokinin-2; Sex Factors; Symptom Assessment; Thiophenes; Young Adult

2017

Other Studies

9 other study(ies) available for thiophenes and ibodutant

Article	Year
MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist. European journal of pharmacology, 2006, Nov-07, Volume: 549, Issue:1-3 Topics: Aged; Animals; Binding, Competitive; Bronchoconstriction; Cell Membrane; CHO Cells; Colon; Cricetinae; Cricetulus; Dipeptides; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Middle Aged; Muscle Contraction; Neurokinin A; Peptide Fragments; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurokinin-2; Swine; Thiophenes; Vasoconstriction	2006
Discovery of a new series of potent and selective linear tachykinin NK2 receptor antagonists. Journal of medicinal chemistry, 2007, Oct-04, Volume: 50, Issue:20 Topics: Administration, Oral; Animals; Caco-2 Cells; Colon; Cyclopentanes; Dipeptides; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Injections; Intestinal Absorption; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Permeability; Piperidines; Pyrans; Radioligand Assay; Receptors, Neurokinin-2; Stereoisomerism; Thiophenes; Urinary Bladder	2007
Multifaceted approach to determine the antagonist molecular mechanism and interaction of ibodutant ([1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl)-cyclopentyl]-amide) at the human tachykinin NK2 receptor. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:2 Topics: Animals; Benzamides; Binding, Competitive; Cell Line; Cloning, Molecular; Cricetinae; Cricetulus; Dipeptides; Dose-Response Relationship, Drug; Humans; Kinetics; Models, Molecular; Peptides, Cyclic; Phosphatidylinositols; Piperidines; Protein Binding; Radioligand Assay; Receptors, Neurokinin-2; Thiophenes; Type C Phospholipases	2009
Modulation on C- and N-terminal moieties of a series of potent and selective linear tachykinin NK(2) receptor antagonists. ChemMedChem, 2010, Volume: 5, Issue:1 Topics: Animals; Dipeptides; Drug Design; Guinea Pigs; Humans; Receptors, Neurokinin-2; Structure-Activity Relationship; Thiophenes	2010
Effect of otilonium bromide and ibodutant on the internalization of the NK2 receptor in human colon. Neurogastroenterology and motility, 2011, Volume: 23, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Animals; Colon; Dipeptides; Female; Gastrointestinal Agents; Humans; Immunohistochemistry; Male; Middle Aged; Quaternary Ammonium Compounds; Receptors, Neurokinin-2; Thiophenes	2011
Characterization of ibodutant at NK(2) receptor in human colon. European journal of pharmacology, 2013, Feb-28, Volume: 702, Issue:1-3 Topics: Aged; Aged, 80 and over; Benzamides; Binding, Competitive; Colon; Dipeptides; Female; Humans; In Vitro Techniques; Male; Middle Aged; Peptides, Cyclic; Piperidines; Radioligand Assay; Receptors, Neurokinin-2; Thiophenes	2013
Antagonist profile of ibodutant at the tachykinin NK(2) receptor in guinea pig isolated bronchi. European journal of pharmacology, 2013, Nov-15, Volume: 720, Issue:1-3 Topics: Allergens; Animals; Bronchi; Bronchoconstriction; Dipeptides; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Receptors, Neurokinin-2; Thiophenes	2013
Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon. British journal of pharmacology, 2016, Volume: 173, Issue:8 Topics: Animals; Colitis; Colon; Dipeptides; Disease Models, Animal; Female; Guinea Pigs; Hyperalgesia; Male; Receptors, Neurokinin-2; Sex Characteristics; Thiophenes; Trinitrobenzenesulfonic Acid; Visceral Pain	2016
Gender-Related Differences of Tachykinin NK The Journal of pharmacology and experimental therapeutics, 2020, Volume: 375, Issue:1 Topics: Colon; Dipeptides; Electric Stimulation; Female; Gene Expression; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons; Peptide Fragments; Receptors, Neurokinin-2; Sex Characteristics; Signal Transduction; Thiophenes	2020