Page last updated: 2024-08-18

thiophenes and guanine

thiophenes has been researched along with guanine in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (35.85)	18.2507
2000's	24 (45.28)	29.6817
2010's	9 (16.98)	24.3611
2020's	1 (1.89)	2.80

Authors

Authors	Studies
Duffy, EM; Jorgensen, WL	1
Conroy, MC; Dong, MK; Gilbertsen, RB; Josyula, U; Sircar, JC; Wilburn, DJ; Wu, WS	1
DeMatos, P; Egner, PA; Groopman, JD; Kensler, TW; Love-Hunt, A	1
Cetenko, WA; Dong, MK; Gilbertsen, RB; Kostlan, CR; Sircar, JC	1
Bonmassar, E; Lu, K; McGuire, JJ; Rustum, YM; Yin, MB	1
Boehncke, WH; Gilbertsen, RB; Hemmer, J; Sterry, W	1
Dong, MK; Gilbertsen, RB; Wilburn, DJ	1
Dong, MK; Gilbertsen, RB	1
Conroy, MC; Dong, MK; Gilbertsen, RB; Josyula, U; Sircar, JC; Wilburn, DJ	1
Calvert, AH; Jackman, AL	1
Hanauske, AR	1
Groopman, JD; Kensler, TW	1
Andis, SL; Beardsley, GP; Bewley, JR; Chen, VJ; Gates, SB; Gossett, LS; Habeck, LL; Kohler, W; MacKellar, WC; Mendelsohn, LG; Moroson, BA; Patel, VF; Ratnam, M; Rayl, EA; Schultz, RM; Shackelford, KA; Shih, C; Soose, DJ	1
Takimoto, CH	1
Andis, SL; Bewley, JR; Chen, VJ; Iversen, PW; Mendelsohn, LG; Schultz, RM; Seitz, DE; Shih, C; Tonkinson, JL	2
Adjei, AA	1
Bewley, JR; Chen, VJ; Dempsey, JA; Roberts, EF; Schultz, RM; Shih, C	1
Danenberg, PV; Malli, H; Swenson, S	1
Allay, JA; Belt, JA; Patel, DH; Sorrentino, BP	1
Kuiper, CM; Peters, GJ; van der Wilt, CL	1
Aherne, GW; Brunton, L; Jackman, AL; Monaghan, P; Titley, J; Valenti, M; Welsh, SJ	1
Cassidy, J	1
Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D	1
Curtin, NJ; Errington, J; Lu, X; Lunec, J; Newell, DR	1
Backus, HH; Kuiper, CM; Peters, GJ; Pinedo, HM; van der Wilt, CL; van Groeningen, CJ; Wouters, D	1
Fizazi, K; John, WJ; Vogelzang, NJ	1
Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH	1
Vogelzang, NJ	1
Jackman, AL; Theti, DS	1
Chattopadhyay, S; Goldman, ID; Hanscom, M; Zhao, R	1
Goldman, ID; Wang, Y; Zhao, R	1
Klabatsa, A; Steele, JP	1
Chattopadhyay, S; Goldman, ID; Krupenko, N; Krupenko, SA; Zhao, R	1
Garcia-Carbonero, R; Paz-Ares, L	1
Glintborg, B; Kensler, TW; Poulsen, HE; Weimann, A	1
Aelony, Y	1
Davies, AM; Ellis, P; Evans, WK; Haynes, AE; Lloyd, NS	1
Bijnsdorp, IV; Comijn, EM; Gmeiner, WH; Padron, JM; Peters, GJ	1
Burkitt, V	1
Gatzemeier, U; Heigener, DF; Reck, M	1
Anraku, M; Bezjak, A; Burkes, R; Cho, BC; de Perrot, M; Feld, R; Johnston, MR; Keshavjee, S; Leighl, N; Roberts, H; Tsao, MS	1
De Vincenzo, F; Santoro, A; Simonelli, M; Zucali, PA	1
Paracha, N; Scott, DA; Thatcher, N; Woods, B	1
Grosso, F; Scagliotti, GV	1
Agarwal, V; Cawkwell, L; Eagle, GL; Hodgkinson, VC; Lind, MJ; Scaife, L	1
Guan, W; Hu, J; Liu, B; Qian, X; Shen, J; Wang, H; Wei, J; Xie, L; Yu, L; Zhang, Q	1
Beer, DG; Bergeron, EJ; Chen, G; Giordano, TJ; Grabauskiene, S; Morgan, MA; Reddy, RM; Thomas, DG	1
Boykin, DW; David-Cordonnier, MH; Depauw, S; Farahat, AA; Ismail, MA; Kumar, A; Munde, M; Paul, A; Peixoto, P; Say, MV; Wilson, WD	1
Goldman, ID; Visentin, M; Zhao, R	1
Fujitsuka, M; Lin, SH; Majima, T	1
Bou Zerdan, R; Castellano, RK; Fagnani, DE	1
Ambrus-Aikelin, G; Imamura, S; Kimura, H; Kitazawa, S; Klein, MG; Kurasawa, O; Matsumoto, S; Morishita, D; Ogawa, K; Okaniwa, M; Ono, K; Saito, B; Tanaka, Y; Uchiyama, N; Yokota, A	1

Reviews

15 review(s) available for thiophenes and guanine

Article	Year
Folate-based thymidylate synthase inhibitors as anticancer drugs. Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:9 Topics: Antineoplastic Agents; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	1995
The development of new chemotherapeutic agents. Anti-cancer drugs, 1996, Volume: 7 Suppl 2 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Irinotecan; Neoplasms; Pemetrexed; Quinazolines; Thiophenes; Trimetrexate	1996
Carcinogen-DNA and protein adducts: biomarkers for cohort selection and modifiable endpoints in chemoprevention trials. Journal of cellular biochemistry. Supplement, 1996, Volume: 25 Topics: Aflatoxin B1; Aflatoxins; Aged; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Clinical Trials as Topic; Cohort Studies; DNA Adducts; Guanine; Hepatitis B; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Proteins; Pyrazines; Risk Factors; Thiones; Thiophenes	1996
Antifolates in clinical development. Seminars in oncology, 1997, Volume: 24, Issue:5 Suppl 18 Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase	1997
A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer. British journal of clinical pharmacology, 1999, Volume: 48, Issue:3 Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Glutamates; Guanine; Humans; Pemetrexed; Platinum Compounds; Pyridines; Quinazolines; Tegafur; Thiophenes; Uracil	1999
Thymidylate synthase inhibitors. Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	1999
Thymidylate synthase inhibitors in colorectal cancer. Seminars in oncology, 2000, Volume: 27, Issue:5 Suppl 10 Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	2000
The emerging role of antifolates in the treatment of malignant pleural mesothelioma. Seminars in oncology, 2002, Volume: 29, Issue:1 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Folic Acid Antagonists; Glutamates; Guanine; Humans; Mesothelioma; Organoplatinum Compounds; Oxaliplatin; Pemetrexed; Pleural Neoplasms; Quinazolines; Thiophenes	2002
Emerging insights into the biology and therapy of malignant mesothelioma. Seminars in oncology, 2002, Volume: 29, Issue:6 Suppl 18 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Folic Acid Antagonists; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	2002
Chemotherapy options and new advances in malignant pleural mesothelioma. Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Palliative Care; Pemetrexed; Pleural Neoplasms; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes	2005
Systemic chemotherapy in the management of malignant peritoneal mesothelioma. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2006, Volume: 32, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Gemcitabine; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Peritoneal Neoplasms; Quinazolines; Thiophenes; Vinblastine; Vinorelbine	2006
The use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2006, Volume: 1, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Female; Glutamates; Guanine; Humans; Male; Maximum Tolerated Dose; Mesothelioma; Neoplasm Invasiveness; Patient Selection; Pemetrexed; Pleural Neoplasms; Practice Guidelines as Topic; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thiophenes; Treatment Outcome	2006
[Chemotherapy of malignant pleural mesothelioma: have we made any progress?]. Zentralblatt fur Chirurgie, 2008, Volume: 133, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disease-Free Survival; Glutamates; Guanine; Humans; Mesothelioma; Neoplasm Staging; Pemetrexed; Pleural Neoplasms; Prognosis; Quinazolines; Randomized Controlled Trials as Topic; Retreatment; Thiophenes	2008
Future developments in the management of malignant pleural mesothelioma. Expert review of anticancer therapy, 2009, Volume: 9, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cisplatin; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Diagnostic Imaging; Disease Management; Drug Delivery Systems; Forecasting; Glutamates; Guanine; Humans; Mesothelioma; Mice; Multicenter Studies as Topic; Neoplasm Proteins; Neoplasm Staging; Pemetrexed; Pleural Neoplasms; Quinazolines; Radiotherapy, Intensity-Modulated; Randomized Controlled Trials as Topic; Thiophenes; Thoracic Surgical Procedures; Vinblastine; Vinorelbine	2009
Systemic treatment of malignant pleural mesothelioma. Future oncology (London, England), 2012, Volume: 8, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Pleura; Pleural Neoplasms; Quinazolines; Thiophenes; Treatment Outcome	2012

Trials

1 trial(s) available for thiophenes and guanine

Article	Year
Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers. Free radical biology & medicine, 2006, Sep-15, Volume: 41, Issue:6 Topics: Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; China; DNA; Guanine; Humans; Liver Neoplasms; Oxidation-Reduction; Oxidative Stress; Placebos; Pyrazines; Thiones; Thiophenes	2006

Other Studies

37 other study(ies) available for thiophenes and guanine

Article	Year
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955. Biochemical pharmacology, 1992, Sep-01, Volume: 44, Issue:5 Topics: Animals; Cell Line; Deoxyguanine Nucleotides; Dose-Response Relationship, Drug; Guanine; Guanosine; Humans; Inosine; Male; Purine-Nucleoside Phosphorylase; Pyrimidines; Rats; Rats, Inbred Strains; T-Lymphocytes; Thiophenes	1992
Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats. Carcinogenesis, 1992, Volume: 13, Issue:1 Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Biomarkers; DNA; Guanine; Liver Neoplasms, Experimental; Male; Protein Binding; Pyrazines; Rats; Rats, Inbred F344; Serum Albumin; Thiones; Thiophenes	1992
Pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase (PNP) inhibitors as potential T-cell selective immunosuppressive agents. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Cell Line; Erythrocytes; Guanine; Humans; Immunosuppressive Agents; Kinetics; Purine-Nucleoside Phosphorylase; Pyrimidines; Structure-Activity Relationship; T-Lymphocytes; Thiophenes	1991
Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line. Biochemical pharmacology, 1995, Jul-31, Volume: 50, Issue:3 Topics: Cell Division; Cell-Free System; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Pemetrexed; Peptide Synthases; Pteroylpolyglutamic Acids; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured	1995
Evidence for a pathway independent from 2'-deoxyguanosine and reversible by IL-2 by which purine nucleoside phosphorylase inhibitors block T-cell proliferation. Scandinavian journal of immunology, 1994, Volume: 39, Issue:3 Topics: Cell Cycle; Cell Line; Deoxyguanosine; Flow Cytometry; Guanine; Humans; Interleukin-2; Interleukin-7; Lymphocyte Activation; Mycosis Fungoides; Purine-Nucleoside Phosphorylase; Pyrimidines; S Phase; Sezary Syndrome; T-Lymphocytes; Thiophenes; Time Factors	1994
PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. I. Suppression of the human mixed lymphocyte reaction (MLR). Agents and actions, 1993, Volume: 39 Spec No Topics: Cells, Cultured; Guanine; Humans; Immunosuppressive Agents; Lymphocyte Culture Test, Mixed; Purine-Nucleoside Phosphorylase; Pyrimidines; T-Lymphocytes; Thiophenes	1993
PD 141955 and CI-972: 9-deazaguanine analog purine nucleoside phosphorylase inhibitors. II. Effects on nucleoside catabolism in human and rat blood in vitro. Agents and actions, 1993, Volume: 39 Spec No Topics: Animals; Chromatography, High Pressure Liquid; Deoxyguanosine; Guanine; Half-Life; Humans; Immunosuppressive Agents; Purine-Nucleoside Phosphorylase; Pyrimidines; Rats; Thiophenes	1993
Activities of two 9-deazaguanine analogue inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955, in vitro and in vivo. Annals of the New York Academy of Sciences, 1993, Jun-23, Volume: 685 Topics: Animals; Cell Division; Deoxyguanine Nucleotides; Dose-Response Relationship, Drug; Guanine; Humans; Immunosuppressive Agents; Purine-Nucleoside Phosphorylase; Pyrimidines; Rats; Thiophenes; Tumor Cells, Cultured	1993
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer research, 1997, Mar-15, Volume: 57, Issue:6 Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Acyltransferases; Aminohydrolases; Antimetabolites, Antineoplastic; Folic Acid Antagonists; Formate-Tetrahydrofolate Ligase; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Molecular Structure; Multienzyme Complexes; Oxidoreductases; Pemetrexed; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Polyglutamic Acid; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1997
Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. British journal of cancer, 1998, Volume: 78 Suppl 3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Nucleotides; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1998
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6 Topics: Acid Anhydride Hydrolases; Antimetabolites, Antineoplastic; Deoxyribonucleotides; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Nucleoside-Diphosphate Kinase; Nucleoside-Triphosphatase; Pemetrexed; Quinazolines; Ribonucleotides; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured	1999
Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6 Topics: Antimetabolites, Antineoplastic; Biological Transport; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1999
Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells. Blood, 2000, Apr-01, Volume: 95, Issue:7 Topics: 3T3 Cells; Animals; Bone Marrow Cells; Carrier Proteins; Cell Death; DNA, Complementary; Drug Resistance; Drug Synergism; Equilibrative-Nucleoside Transporter 2; Female; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Vectors; Glutamates; Guanine; Hematopoietic Stem Cells; Membrane Proteins; Mice; Mice, Inbred C57BL; Pemetrexed; Quinazolines; Retroviridae; Thioinosine; Thiophenes	2000
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines. Oncology research, 1999, Volume: 11, Issue:8 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; DNA Damage; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1999
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:6 Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Flow Cytometry; Fluorouracil; Glutamates; Guanine; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Mice; Mice, Inbred DBA; Microscopy, Confocal; Neoplasm Transplantation; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured; Up-Regulation	2000
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. Cancer research, 2001, May-01, Volume: 61, Issue:9 Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase	2001
The impact of p53 status on cellular sensitivity to antifolate drugs. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:7 Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Mutational Analysis; DNA, Neoplasm; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Genotype; Glutamates; Guanine; Humans; Methotrexate; Mutation; Pemetrexed; Quinazolines; Sensitivity and Specificity; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2001
Thymidylate synthase inhibition induces p53 dependent and independent cell death. Advances in experimental medicine and biology, 2000, Volume: 486 Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspases; Colonic Neoplasms; DNA Damage; Enzyme Inhibitors; Fas Ligand Protein; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Membrane Glycoproteins; Pemetrexed; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2 Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	2002
The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Feb-01, Volume: 10, Issue:3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Models, Chemical; Neoplasms; Pemetrexed; Quinazolines; Receptors, Cell Surface; Thiophenes; Time Factors	2004
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway. Cancer research, 2004, May-01, Volume: 64, Issue:9 Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Division; Drug Resistance, Neoplasm; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Membrane Transport Proteins; Ornithine; Pemetrexed; Polyglutamic Acid; Pterins; Quinazolines; Reduced Folate Carrier Protein; Thiophenes	2004
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Sep-15, Volume: 10, Issue:18 Pt 1 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Blotting, Northern; Carrier Proteins; Cell Line; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Membrane Transport Proteins; Methotrexate; Pemetrexed; Protein Isoforms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; RNA; Thiophenes; Time Factors; Transfection; Trimetrexate	2004
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Molecular cancer therapeutics, 2006, Volume: 5, Issue:2 Topics: Amino Acid Substitution; Antineoplastic Agents; Arginine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Glutamates; Glycine; Guanine; Humans; Leucovorin; Methotrexate; Mutation; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Purines; Pyrimidines; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase	2006
Raltitrexed and pemetrexed studies in mesothelioma have not shown improved quality of life nor prolonged survival compared with effective pleurodesis with thoracoscopic talc poudrage. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Oct-01, Volume: 24, Issue:28 Topics: Cisplatin; Clinical Trials as Topic; Glutamates; Guanine; Humans; Mesothelioma; Pemetrexed; Pleural Neoplasms; Pleurodesis; Quality of Life; Quinazolines; Talc; Thiophenes; Treatment Outcome	2006
Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition. Oncology reports, 2007, Volume: 18, Issue:1 Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	2007
In Australia, patients and government at odds over mesothelioma treatment costs. Journal of the National Cancer Institute, 2007, Dec-05, Volume: 99, Issue:23 Topics: Abdominal Neoplasms; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asbestos; Australia; Canada; Carcinogens; Cisplatin; Cost-Benefit Analysis; Environmental Exposure; Glutamates; Government; Guanine; Health Care Costs; Humans; Incidence; Lobbying; Lung Neoplasms; Mesothelioma; Patient Advocacy; Pemetrexed; Quinazolines; Thiophenes; Thoracic Neoplasms; United Kingdom	2007
Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Mar-20, Volume: 27, Issue:9 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Glutamates; Guanine; Humans; Male; Mesothelioma; Middle Aged; Neoadjuvant Therapy; Pemetrexed; Pleural Neoplasms; Pneumonectomy; Quinazolines; Radiotherapy, Adjuvant; Remission Induction; Retrospective Studies; Thiophenes; Vinblastine; Vinorelbine	2009
Raltitrexed plus cisplatin is cost-effective compared with pemetrexed plus cisplatin in patients with malignant pleural mesothelioma. Lung cancer (Amsterdam, Netherlands), 2012, Volume: 75, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cost-Benefit Analysis; Glutamates; Guanine; Health Care Costs; Humans; Mesothelioma; Pemetrexed; Pleural Neoplasms; Quality-Adjusted Life Years; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes	2012
Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697. International journal of oncology, 2013, Volume: 42, Issue:3 Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Pemetrexed; Protein Array Analysis; Proteomics; Thiophenes	2013
TS mRNA levels can predict pemetrexed and raltitrexed sensitivity in colorectal cancer. Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:2 Topics: Antineoplastic Agents; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Female; Fluorouracil; Glutamates; Guanine; Humans; Immunohistochemistry; Male; Middle Aged; Pemetrexed; Predictive Value of Tests; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase	2014
Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non-small cell lung cancer. The Journal of surgical research, 2014, Volume: 187, Issue:1 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Protein Kinase Inhibitors; Protein Kinases; Thiophenes; Urea	2014
The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine. Biochemistry, 2014, Feb-25, Volume: 53, Issue:7 Topics: Amidines; Amino Acid Sequence; Biosensing Techniques; Deoxyribonuclease I; DNA; DNA Footprinting; Guanine; Models, Molecular; Surface Plasmon Resonance; Thiophenes; Transition Temperature	2014
Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis. Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:6 Topics: Cell Line, Tumor; Endocytosis; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Quinazolines; Reduced Folate Carrier Protein; Thiophenes	2015
How Does Guanine-Cytosine Base Pair Affect Excess-Electron Transfer in DNA? The journal of physical chemistry. B, 2015, Jun-25, Volume: 119, Issue:25 Topics: Acetylene; Base Pairing; Circular Dichroism; Cytosine; DNA; Electron Transport; Electrons; Guanine; Photolysis; Photosensitizing Agents; Protons; Spectrometry, Fluorescence; Thiophenes; Thymine; Transition Temperature	2015
Synthesis, Optoelectronic Properties, Self-Association, and Base Pairing of Nucleobase-Functionalized Oligothiophenes. The Journal of organic chemistry, 2018, 10-19, Volume: 83, Issue:20 Topics: Adenine; Base Pairing; Chloroform; Cytosine; Dimerization; Dimethylformamide; Electrochemical Techniques; Guanine; Hydrogen Bonding; Molecular Structure; Semiconductors; Solvents; Thermodynamics; Thiophenes; Uracil	2018
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase. Journal of medicinal chemistry, 2020, 03-26, Volume: 63, Issue:6 Topics: Allosteric Site; Crystallography, X-Ray; Drug Discovery; Enzyme Assays; Enzyme Inhibitors; Guanine; High-Throughput Screening Assays; Humans; Indoles; Molecular Structure; NAD; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Protein Conformation; Spermidine; Structure-Activity Relationship; Thiophenes	2020