thiophenes has been researched along with gsk4112 in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (92.31) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, JL; Grant, D; Joshi, S; Lazar, MA; Orband-Miller, LA; Parks, DJ; Willson, TM; Wisely, GB; Yin, L; Zuercher, WJ | 1 |
| Chen, H; Chu, G; Hashimoto, S; Hattori, MA; Shigeyoshi, Y; Yamauchi, N; Zhao, L | 1 |
| Blaikley, J; Boudjelal, M; Bresciani, S; Cooper, AW; Dawson, HC; Farrow, SN; Grant, D; Kashatus, JA; Loudon, A; Orband-Miller, LA; Ray, D; Tellam, JP; Tomkinson, NC; Trump, RP; Willson, TM; Wojno, J | 1 |
| Burris, TP; Fernandez-Ruiz, R; Figueroa, AL; Gomis, R; Marroquí, L; Merino, B; Nadal, A; Quesada, I; Vieira, E | 1 |
| Imaizumi, K; Izawa, T; Kizaki, T; Ogasawara, J; Ohno, H; Sakurai, T; Sato, S; Takahashi, M; Taniguchi, N | 1 |
| Chen, H; Hashimoto, S; Hattori, MA; Isayama, K; Kumazawa, M; Shigeyoshi, Y; Yamauchi, N; Zhao, L | 1 |
| Rahman, I; Rashid, K; Sellix, MT; Sundar, IK | 1 |
| Batista, TM; Borck, PC; Boschero, AC; Camargo, RL; Carneiro, EM; Vettorazzi, JF; Vieira, E | 1 |
| Guo, DK; Hao, ZB; Mu, CC; Ren, HG; Sun, HY; Wang, GH; Xu, XY; Zhang, S; Zhu, Y | 1 |
| Hisaoka-Nakashima, K; Kodama, K; Morioka, N; Nakamura, Y; Nakata, Y; Saeki, M; Tomori, M; Yoshikawa, K; Zhang, FF | 1 |
| Fang, X; Gao, J; Ge, Y; Huang, T; Li, Y; Xiao, H; Xu, Y; Yu, D; Zhang, Y; Zong, L | 1 |
| Chu, G; Hu, Y; Shi, S; Yang, G; Zhou, X | 1 |
| Fan, K; Jiang, R; Li, L; Liu, G; Shao, R; Shen, Y; Tang, L; Wu, X; Yang, Y; Zhang, L | 1 |
13 other study(ies) available for thiophenes and gsk4112
| Article | Year |
|---|---|
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cells, Cultured; Circadian Rhythm; Glycine; Heme; Hepatocytes; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Subfamily 1, Group D, Member 1; Peptides; Protein Interaction Mapping; Small Molecule Libraries; Thiophenes | 2010 |
Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112.
Topics: Animals; ARNTL Transcription Factors; Circadian Rhythm; Female; Gene Expression Regulation; Glycine; Granulosa Cells; Nuclear Receptor Subfamily 1, Group D, Member 1; Period Circadian Proteins; Phosphoproteins; Promoter Regions, Genetic; Rats; Thiophenes | 2012 |
Optimized chemical probes for REV-ERBα.
Topics: Amines; Animals; Biological Availability; Carrier Proteins; Cell Line; Circadian Rhythm; Glycine; Humans; Liver X Receptors; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Orphan Nuclear Receptors; Peptide Fragments; Radioligand Assay; RNA-Binding Proteins; Structure-Activity Relationship; Thiophenes | 2013 |
Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Circadian Rhythm; Cytokines; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Glycine; Isoquinolines; Metformin; Mice; Nicotinamide Phosphoribosyltransferase; Nuclear Receptor Subfamily 1, Group D, Member 1; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Thiophenes | 2013 |
A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
Topics: Age Factors; Animals; Cell Adhesion; Cell Line; Cell Movement; Chemokine CCL2; Circadian Clocks; Gene Expression; Gene Expression Regulation; Glycine; Inflammation; Integrin beta1; Lipopolysaccharides; Macrophages; Macrophages, Peritoneal; Male; Mice; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; Nuclear Receptor Subfamily 1, Group F, Member 1; Obesity; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Response Elements; Thiophenes; Transcriptional Activation; Vascular Cell Adhesion Molecule-1 | 2014 |
Integration of the nuclear receptor REV-ERBα linked with circadian oscillators in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells.
Topics: 5-Aminolevulinate Synthetase; Animals; Animals, Genetically Modified; Circadian Rhythm; Female; Gene Expression Regulation; Glycine; Granulosa Cells; Heme; Interleukin-6; Isoquinolines; Ligands; Nuclear Receptor Subfamily 1, Group D, Member 1; Ovary; Period Circadian Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; RNA, Small Interfering; Thiophenes; Transcription Factors | 2015 |
The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation.
Topics: Animals; Cells, Cultured; Cytokines; Epithelial Cells; Female; Glycine; Humans; Inflammation Mediators; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Nuclear Receptor Subfamily 1, Group D, Member 1; Pneumonia; Smoke; Smoking; Thiophenes | 2017 |
Protein malnutrition after weaning disrupts peripheral clock and daily insulin secretion in mice.
Topics: Adipose Tissue, White; Animals; Biological Clocks; CLOCK Proteins; Diet, Protein-Restricted; Gene Expression Regulation, Developmental; Glycine; Hypothalamus; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoquinolines; Liver; Male; Mice, Inbred C57BL; Muscle, Skeletal; Neurons; Neuropeptide Y; Nuclear Receptor Subfamily 1, Group D, Member 1; Organ Specificity; Pro-Opiomelanocortin; Protein Deficiency; Random Allocation; Thiophenes; Weaning | 2017 |
Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway.
Topics: Animals; Cell Line, Tumor; Glycine; HEK293 Cells; Humans; Inflammation; Male; Mesencephalon; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Signal Transduction; Thiophenes; Transcription Factor RelA | 2019 |
Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice.
Topics: Animals; Astrocytes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glycine; Hyperalgesia; Inflammation; Interleukin-6; Male; Mice; Neuralgia; Nociceptors; Nuclear Receptor Subfamily 1, Group D, Member 1; Primary Cell Culture; Pyrrolidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Spinal Cord; Spinal Cord Dorsal Horn; Thiophenes; Tumor Necrosis Factor-alpha | 2019 |
Rev-erbα can regulate the NF-κB/NALP3 pathway to modulate lipopolysaccharide-induced acute lung injury and inflammation.
Topics: Acute Lung Injury; Animals; Glycine; Interleukin-1beta; Isoquinolines; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; RAW 264.7 Cells; Signal Transduction; Thiophenes | 2019 |
Rev-erbα Inhibits Proliferation and Promotes Apoptosis of Preadipocytes through the Agonist GSK4112.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Apoptosis; Cell Proliferation; Glycine; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Thiophenes | 2019 |
REV-ERBα Agonist GSK4112 attenuates Fas-induced Acute Hepatic Damage in Mice.
Topics: Acute Disease; Animals; Antibodies; Apoptosis; Chemical and Drug Induced Liver Injury; Circadian Rhythm; fas Receptor; Glycine; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Thiophenes | 2021 |