Compounds > thiophenes
Page last updated: 2024-08-18

thiophenes and gsk0660

thiophenes has been researched along with gsk0660 in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (2.56)29.6817
2010's32 (82.05)24.3611
2020's6 (15.38)2.80

Authors

AuthorsStudies
Billin, AN; Grillot, DA; Iannone, MA; Lazar, MA; Lobe, DC; Shearer, BG; Stanley, TB; Steger, DJ; Way, JM; Willson, TM1
Duarte, J; Galindo, P; Gómez-Guzmán, M; Haro, JM; Jiménez, R; López-Sepúlveda, R; Pérez-Vizcaíno, F; Quintela, AM; Romero, M; Sánchez, M; Zarzuelo, A; Zarzuelo, MJ1
Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Galuppo, M; Kapoor, A; Mazzon, E; Paterniti, I; Thiemermann, C1
Alvarez-Guardia, D; Barroso, E; Coll, T; Gómez-Foix, AM; Laguna, JC; Palomer, X; Vázquez-Carrera, M1
Chen, LJ; Chen, ZC; Cheng, JT; Chung, HH; Fan, SC; Yu, BC1
Bahrami, S; Bishop-Bailey, D; Busch, D; Castiglia, S; Collino, M; Desvergne, B; Fantozzi, R; Kapoor, A; Mitchell, JA; Mota-Filipe, H; Osuchowski, MF; Patel, NS; Sepodes, B; Shintani, Y; Suzuki, K; Thiemermann, C; Yaqoob, MM1
Diederich, WE; Dörr, SM; Klebe, G; Müller, R; Naruhn, S; Pape, VF; Toth, PM1
Booth, K; Foerster, J; Hack, K; Kime, R; Norval, S; Palmer, C; Read, KD; Reilly, L1
Evans, RM; Martin, HL; Mounsey, RB; Mustafa, S; Nelson, MC; Sathe, K; Teismann, P1
Capozzi, ME; McCollum, GW; Penn, JS; Savage, SR1
Chabbi-Achengli, Y; Collet, C; de Vernejoul, MC; Launay, JM; Maroteaux, L1
Gong, M; Lu, Y; Mao, T; Tong, N; Tong, Y; Wang, C; Yang, Q; Yang, Y; Zhou, M1
Bao, XC; Fang, YQ; Ma, J; You, P; Zhang, S2
Galatou, E; Kelly, T; Lazou, A1
Do, JT; Ham, SA; Hwang, JS; Kang, ES; Kim, JH; Paek, KS; Park, C; Seo, HG; Yoo, T1
Bretz, CA; Capozzi, ME; McCollum, GW; Penn, JS; Suarez, S; Yang, R1
McCollum, GW; Penn, JS; Savage, SR; Yang, R1
Cogolludo, Á; Duarte, J; Gálvez, J; Gómez-Guzmán, M; Hermenegildo, C; Jiménez, R; Pérez-Vizcaíno, F; Romero, M; Toral, M; Utrilla, MP; Zarzuelo, MJ1
Barroso, E; Briones, AM; Cogolludo, Á; Duarte, J; García-Redondo, AB; Gómez-Guzmán, M; Jiménez, R; Mahmoud, AM; Pérez-Vizcaíno, F; Romero, M; Sánchez, M; Toral, M; Vázquez-Carrera, M1
Andel, M; Malisova, L; Trnka, J; Tumova, J1
Do, JT; Ham, SA; Han, CW; Hwang, JS; Kim, JH; Lee, WJ; Oh, JW; Paek, KS; Seo, HG; Yoo, T1
Chen, LJ; Cheng, JT; Niu, HS; Tong, YC; Wu, TT1
Duarte, J; Jiménez, R; Martínez, MC; Pérez-Vizcaíno, F; Robles-Vera, I; Romero, M; Tamargo, J; Toral, M1
Dessy, C; Duarte, J; Gómez-Gúzman, M; Jiménez, R; León-Gómez, E; Pérez-Vizcaíno, F; Rath, G; Rodríguez-Gómez, I; Romero, M; Sánchez, M; Tamargo, J; Toral, M; Zarzuelo, MJ1
Agarwal, AK; Garg, A; Sankella, S1
Adhikary, T; Häring, HU; Klingler, C; Lehmann, R; Li, J; Schleicher, E; Weigert, C; Xu, G; Zhao, X1
Bahrami, S; Busch, D; Hildebrand, F; Kapoor, A; Osuchowski, MF; Rademann, P; Thiemermann, C1
Chang, WT; Chen, ZC; Cheng, JT; Cheng, KC; Cheng, YZ; Li, Y1
Chen, F; Du, Y; Hong, H; Kong, L; Mei, Z; Meng, G; Reed, MN; Sun, H; Suppiramaniam, V; Tang, S; Yu, X1
Liu, J; Tian, Y; Wang, N; Xiao, L; Xie, X; Yang, C; Yao, Q; Zhang, Z1
Chen, R; Cheng, O; Ding, S; Huang, B; Huang, J; Jiang, Q; Qiu, H; Zhang, J1
Cong, H; Fan, B; Gu, J; Wang, T; Zhong, W1
Bretz, CA; Capozzi, ME; Hammer, SS; McCollum, GW; Penn, JS; Ramos, CJ; Savage, SR; Yang, R1
Finn, DP; Gaspar, JC; Llorente-Berzal, A; Okine, BN; Roche, M1
Hirao-Suzuki, M; Koga, T; Takeda, S; Takiguchi, M; Toda, A1
Berga, SL; Man, M; Rajakumar, A; Sidell, N; Taylor, RN; Yu, J; Zou, W1
Andrés, A; Fernández, A; Gallardo, N; López, V; Mazuecos, L; Mora, C; Pintado, C; Rubio, B1
Andrés, A; Gallardo, N; Guisantes-Batán, E; Mazuecos, L; Pintado, C; Rubio, B1

Other Studies

39 other study(ies) available for thiophenes and gsk0660

ArticleYear
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.
    Molecular endocrinology (Baltimore, Md.), 2008, Volume: 22, Issue:2

    Topics: Cells, Cultured; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Fatty Acids; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Humans; Ligands; Molecular Structure; Muscle, Skeletal; Oxidation-Reduction; PPAR delta; PPAR-beta; Sulfones; Thiazoles; Thiophenes

2008
Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2

    Topics: Anilides; Animals; Aorta; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; Morpholines; Nitric Oxide; Nitric Oxide Synthase Type III; Phenoxyacetates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Umbilical Veins; Vasodilation

2010
Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:2

    Topics: Animals; Apoptosis; Cytokines; Enzyme Induction; Fas Ligand Protein; Male; Mice; Neutrophil Infiltration; Nitric Oxide Synthase; Peroxidase; PPAR delta; PPAR-beta; Spinal Cord Injuries; Sulfones; Thiazoles; Thiophenes; Tumor Necrosis Factor-alpha; Tyrosine

2010
Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.
    Endocrinology, 2010, Volume: 151, Issue:4

    Topics: Analysis of Variance; Animals; Blotting, Western; Carnitine O-Palmitoyltransferase; Cell Line; Cell Nucleus; Electrophoretic Mobility Shift Assay; Epoxy Compounds; Fatty Acids; Humans; Insulin Resistance; Interleukin-6; Mice; Muscle, Skeletal; NF-kappa B; PPAR delta; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfones; Thiazoles; Thiophenes

2010
The decreased expression of peroxisome proliferator-activated receptors delta (PPARdelta) is reversed by digoxin in the heart of diabetic rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2010, Volume: 42, Issue:9

    Topics: Animals; Cardiac Output; Diabetes Mellitus, Experimental; Digoxin; Male; Myocardium; Phosphorylation; PPAR delta; Rats; Rats, Wistar; Streptozocin; Sulfones; Thiophenes; Troponin I

2010
Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.
    American journal of respiratory and critical care medicine, 2010, Dec-15, Volume: 182, Issue:12

    Topics: Animals; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Shock, Septic; Signal Transduction; Sulfones; Thiazoles; Thiophenes

2010
Development of improved PPARβ/δ inhibitors.
    ChemMedChem, 2012, Jan-02, Volume: 7, Issue:1

    Topics: Animals; Cell Line; Enzyme Inhibitors; Humans; PPAR delta; PPAR-beta; Structure-Activity Relationship; Sulfones; Thiophenes

2012
Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Administration, Topical; Animals; Benzamides; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ointments; PPAR gamma; PPAR-beta; Psoriasis; Recombinant Proteins; Skin; Skin Absorption; Sulfones; Thiophenes

2012
A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
    Neuroscience, 2013, Jun-14, Volume: 240

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Count; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Female; Glial Fibrillary Acidic Protein; Humans; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Parkinsonian Disorders; PPAR delta; Rats; Sulfones; Thiazoles; Thiophenes; Tyrosine 3-Monooxygenase

2013
Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
    Investigative ophthalmology & visual science, 2013, Jun-19, Volume: 54, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Humans; Oxygen; PPAR delta; PPAR-beta; Rats; Retinal Diseases; Retinal Neovascularization; Retinal Vessels; Sulfones; Thiazoles; Thiophenes

2013
Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ß/δ in osteoblasts.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Animals; Biomarkers; Cell Adhesion; Epoprostenol; Gene Expression Profiling; Mice; Mice, Knockout; Osteoblasts; Phenotype; PPAR delta; PPAR-beta; Primary Cell Culture; Receptor, Serotonin, 5-HT2B; Signal Transduction; Sulfones; Thiophenes

2013
Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor.
    Cellular signalling, 2014, Volume: 26, Issue:2

    Topics: Animals; Apoptosis; Cells, Cultured; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Palmitates; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Receptors, Glucagon; RNA Interference; RNA, Small Interfering; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Up-Regulation

2014
Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels.
    Experimental lung research, 2014, Volume: 40, Issue:3

    Topics: Acute Lung Injury; Animals; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Oxygen; PPAR delta; PPAR-beta; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfones; Thiazoles; Thiophenes; Up-Regulation

2014
Protective role of peroxisome proliferator-activated receptor β/δ in acute lung injury induced by prolonged hyperbaric hyperoxia in rats.
    Respiratory physiology & neurobiology, 2014, Aug-01, Volume: 199

    Topics: Acute Lung Injury; Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Hyperoxia; Lung; Male; MAP Kinase Signaling System; Neuroprotective Agents; NF-kappa B; PPAR delta; PPAR-beta; Pressure; Random Allocation; Rats, Sprague-Dawley; Respiratory System Agents; Sulfones; Thiazoles; Thiophenes; Time Factors

2014
The PPARβ/δ agonist GW0742 modulates signaling pathways associated with cardiac myocyte growth via a non-genomic redox mechanism.
    Molecular and cellular biochemistry, 2014, Volume: 395, Issue:1-2

    Topics: Animals; Gene Expression Regulation; Male; MAP Kinase Signaling System; Myocytes, Cardiac; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors; PTEN Phosphohydrolase; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes; Vanadates

2014
Peroxisome proliferator-activated receptor δ modulates MMP-2 secretion and elastin expression in human dermal fibroblasts exposed to ultraviolet B radiation.
    Journal of dermatological science, 2014, Volume: 76, Issue:1

    Topics: Animals; Dose-Response Relationship, Radiation; Elastin; Fibroblasts; Gene Expression Regulation; Gene Silencing; Homeostasis; Humans; Matrix Metalloproteinase 2; Mice; Microscopy, Fluorescence; PPAR delta; Reactive Oxygen Species; RNA, Small Interfering; Skin; Sulfones; Thiophenes; Ultraviolet Rays; Wound Healing

2014
Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ.
    Investigative ophthalmology & visual science, 2014, Nov-18, Volume: 55, Issue:12

    Topics: Analysis of Variance; Animals; Capillary Permeability; Cell Membrane; Cells, Cultured; Claudin-1; Claudin-5; Electric Impedance; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Immunohistochemistry; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Models, Animal; Peroxisome Proliferator-Activated Receptors; Receptors, Vascular Endothelial Growth Factor; Retina; Retinal Vessels; Sulfones; Thiophenes; Vascular Endothelial Growth Factor A

2014
RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells.
    Molecular vision, 2015, Volume: 21

    Topics: Cells, Cultured; Chemokine CCL8; Cytokines; Endothelial Cells; Gene Expression Regulation; Humans; PPAR delta; PPAR-beta; Retinal Vessels; Sequence Analysis, RNA; Signal Transduction; Sulfones; Thiophenes; Tumor Necrosis Factor-alpha

2015
Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.
    Journal of hypertension, 2015, Volume: 33, Issue:9

    Topics: Adiponectin; Adipose Tissue; Animals; Aorta; Blood Glucose; Caveolin 1; Diet, High-Fat; Endothelium, Vascular; Glucose Tolerance Test; Hypertension; Insulin Resistance; Interleukin-6; Male; Mice; Nitric Oxide Synthase Type III; Obesity; PPAR delta; PPAR-beta; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Vasodilation

2015
Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.
    Clinical science (London, England : 1979), 2015, Volume: 129, Issue:9

    Topics: Animals; Aorta; Blotting, Western; Calcimycin; Carnitine O-Palmitoyltransferase; Cells, Cultured; Diglycerides; Endothelium, Vascular; Enzyme Activation; Lipids; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Palmitic Acids; Phosphorylation; PPAR delta; PPAR-beta; Protein Kinase C-alpha; Reactive Oxygen Species; RNA Interference; Sulfones; Thiazoles; Thiophenes; Up-Regulation

2015
Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation.
    Lipids, 2015, Volume: 50, Issue:10

    Topics: Animals; Cell Death; Cell Line; Cell Survival; Dietary Fats, Unsaturated; Gene Expression Regulation, Enzymologic; Mice; Muscle Cells; Muscle, Skeletal; Palmitic Acid; Receptors, Cytoplasmic and Nuclear; Sulfones; Thiazoles; Thiophenes

2015
Peroxisome proliferator-activated receptor δ inhibits Porphyromonas gingivalis lipopolysaccharide-induced activation of matrix metalloproteinase-2 by downregulating NADPH oxidase 4 in human gingival fibroblasts.
    Molecular oral microbiology, 2016, Volume: 31, Issue:5

    Topics: Cells, Cultured; Collagen; Down-Regulation; Enzyme Activation; Fibroblasts; Gingiva; Humans; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Matrix Metalloproteinase 2; NADPH Oxidase 4; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Porphyromonas gingivalis; PPAR delta; Reactive Oxygen Species; RNA, Small Interfering; Sulfones; Thiazoles; Thiophenes

2016
Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway.
    European journal of pharmacology, 2016, Mar-15, Volume: 775

    Topics: Angiotensin II Type 1 Receptor Blockers; Antineoplastic Agents; Apoptosis; Benzimidazoles; Benzoates; Cell Line, Tumor; Humans; Male; PPAR delta; Prostatic Neoplasms; RNA Interference; RNA, Small Interfering; Sulfones; Telmisartan; Thiophenes

2016
Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.
    Biochemical pharmacology, 2016, 06-15, Volume: 110-111

    Topics: Animals; Aorta; Calcimycin; Cytochrome b Group; Endoplasmic Reticulum Stress; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; PPAR gamma; PPAR-beta; Primary Cell Culture; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Tissue Culture Techniques; Uncoupling Protein 2

2016
Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-β Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:1

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Mesenteric Arteries; Mice, Inbred C57BL; Norepinephrine; PPAR-beta; RGS Proteins; Sulfones; Thiazoles; Thiophenes; Vascular Resistance; Vasoconstriction

2016
Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Acyltransferases; Anilides; Animals; Blotting, Northern; Caco-2 Cells; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Computational Biology; HT29 Cells; Humans; Kidney Tubules, Proximal; Liver; Mice; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; Real-Time Polymerase Chain Reaction; Rosiglitazone; Sulfones; Thiazoles; Thiazolidinediones; Thiophenes; Tyrosine

2016
Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity.
    Biochimica et biophysica acta, 2016, Volume: 1861, Issue:12 Pt A

    Topics: Angiopoietin-Like Protein 4; Angiopoietins; Benzamides; Carnitine O-Palmitoyltransferase; DNA-Binding Proteins; Fatty Acids; Gene Expression; Humans; Inflammation; Lysophosphatidylcholines; Muscle Cells; Muscle Fibers, Skeletal; Muscle, Skeletal; Perilipin-2; PPAR delta; Protective Agents; Protein Kinases; Sulfones; Thiophenes; Transcription, Genetic; Transcriptome; Up-Regulation

2016
Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation.
    Innate immunity, 2018, Volume: 24, Issue:4

    Topics: Animals; Blood Coagulation; Cytokines; Female; Inflammation; Mice; PPAR delta; PPAR-beta; Sepsis; Sulfones; Thiazoles; Thiophenes

2018
GW0742 activates peroxisome proliferator-activated receptor δ to reduce free radicals and alleviate cardiac hypertrophy induced by hyperglycemia in cultured H9c2 cells.
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:11

    Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Cell Line; Free Radicals; Hyperglycemia; Rats; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes

2018
Hippocampal Genetic Knockdown of PPARδ Causes Depression-Like Behaviors and Neurogenesis Suppression.
    The international journal of neuropsychopharmacology, 2019, 06-03, Volume: 22, Issue:6

    Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Proliferation; CREB-Binding Protein; Dentate Gyrus; Depression; Down-Regulation; Gene Knockdown Techniques; Male; Mice; Neural Stem Cells; Neurogenesis; PPAR delta; RNA, Small Interfering; Sulfones; Thiophenes

2019
PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway.
    British journal of pharmacology, 2019, Volume: 176, Issue:16

    Topics: Animals; Aorta; Biopterins; Cells, Cultured; Endothelium, Vascular; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; PPAR delta; Sulfones; Tetrahydrofolate Dehydrogenase; Thiazoles; Thiophenes; Thoracic Arteries

2019
Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
    Experimental cell research, 2019, 09-01, Volume: 382, Issue:1

    Topics: Amidines; Anilides; Animals; Cell Line; Cytochrome P-450 CYP4A; Diabetic Nephropathies; Down-Regulation; Epithelial Cells; Gene Expression Regulation; Glucose; Hydroxyeicosatetraenoic Acids; Indoles; Kidney Tubules; Male; Mice; PPAR alpha; PPAR gamma; PPAR-beta; Rats; Sulfones; Thiophenes

2019
Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2019, Volume: 44, Issue:8

    Topics: Azo Compounds; Chromones; Gene Expression Regulation; Hep G2 Cells; Humans; Imidazoles; Lipid Droplets; Morpholines; Oleic Acid; Oxazoles; Perilipin-5; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; PPAR alpha; Pyridines; Staining and Labeling; Sulfones; Thiophenes; Tyrosine

2019
The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis.
    Experimental eye research, 2020, Volume: 190

    Topics: Adult; Animals; Cells, Cultured; Cytokines; Endothelial Cells; Ependymoglial Cells; Humans; Inflammation; Leukostasis; Male; Mice; Mice, Inbred C57BL; Palmitic Acids; PPAR delta; PPAR-beta; Real-Time Polymerase Chain Reaction; Retina; Retinitis; Sulfones; Thiophenes

2020
Pharmacological Blockade of PPAR Isoforms Increases Conditioned Fear Responding in the Presence of Nociceptive Tone.
    Molecules (Basel, Switzerland), 2020, Feb-24, Volume: 25, Issue:4

    Topics: Analgesia; Anilides; Animals; Conditioning, Psychological; Extinction, Psychological; Fear; Formaldehyde; Freezing Reaction, Cataleptic; Gene Expression; Male; Nociceptive Pain; Oxazoles; PPAR alpha; PPAR delta; PPAR gamma; PPAR-beta; Rats; Rats, Sprague-Dawley; Sulfones; Thiophenes; Tyrosine

2020
Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation.
    The Journal of toxicological sciences, 2020, Volume: 45, Issue:4

    Topics: Breast Neoplasms; Cannabinoids; Cyclooxygenase 2; Female; Gene Expression; Humans; PPAR delta; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Transcription Factor AP-1; Tumor Cells, Cultured

2020
Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?
    The Journal of clinical endocrinology and metabolism, 2020, 09-01, Volume: 105, Issue:9

    Topics: Adult; Cell Differentiation; Cells, Cultured; Decidua; Endometrium; Female; Humans; Infertility, Female; Ligands; Molecular Targeted Therapy; PPAR delta; PPAR-beta; Stromal Cells; Sulfones; Thiazoles; Thiophenes; Up-Regulation

2020
The nutrient sensing pathways FoxO1/3 and mTOR in the heart are coordinately regulated by central leptin through PPARβ/δ. Implications in cardiac remodeling.
    Metabolism: clinical and experimental, 2021, Volume: 115

    Topics: Animals; Cardiomegaly; Forkhead Box Protein O1; Forkhead Box Protein O3; Heart; Leptin; Male; Myocardium; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Sulfones; Thiophenes; TOR Serine-Threonine Kinases; Ventricular Remodeling

2021
Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ.
    International journal of molecular sciences, 2021, Apr-28, Volume: 22, Issue:9

    Topics: Adipose Tissue, White; Animals; Fibroblast Growth Factors; Hypothalamus; Infusions, Intraventricular; Klotho Proteins; Leptin; Male; Membrane Proteins; PPAR gamma; PPAR-beta; Rats, Wistar; Sulfones; Thiophenes

2021