thiophenes has been researched along with gsk 461364 in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (90.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allred, AJ; Barker, D; Barriuso, J; Blagden, SP; Brunetto, AT; Dar, MM; de Bono, JS; Degenhardt, YY; Lampkin, TA; Medani, H; Murray, SC; Olmos, D; Sharma, R; Smith, DA; Taegtmeyer, AB; Wilson, R; Yap, TA | 1 |
| Bakleh, A; Chang, K; Degenhardt, YY; Hannon, GF; Laquerre, S; Li, J; Liu-Sullivan, N; Marchica, J; Powers, S; Siolas, D; Wooster, R; Zhang, J | 1 |
| Abbott, NJ; Bertone, P; Danovi, D; Elbatsh, AM; Ender, C; Engström, PG; Ferretti, P; Folarin, A; Gagrica, S; Georgian, A; Gogolok, S; Harvey, KJ; Paddison, PJ; Pollard, SM; Preston, JE; Smith, A; Stricker, SH; U, KP; Yu, D | 1 |
| Bogado, RF; Brassesco, MS; de Oliveira, HF; Pezuk, JA; Tone, LG | 1 |
| Hsiao, SH; Hsieh, CH; Huang, YH; Li, YQ; Luo, SY; Su, CY; Tuo, WC; Wu, CP | 1 |
| Shin, SB; Woo, SU; Yim, H | 1 |
| Byers, LA; Diao, L; Ferrarotto, R; Gibbons, DL; Girard, L; Giri, U; Glisson, BS; Goonatilake, R; Heymach, JV; Johnson, FM; Li, L; Minna, J; Peng, DH; Peng, S; Tong, P; Wang, J; Wang, L; Wang, Y; Yoo, SY | 1 |
| Chen, TH; Chen, WM; Chou, YS; Ke, WT; Lin, YC; Liu, CL; Liu, CY; Wang, JY; Wen, YS; Yang, MH; Yen, CC | 1 |
| Althoff, K; Dreesmann, S; Eggert, A; Schramm, A; Schulte, JH; Schwermer, M; Steenpass, L; Temming, P | 1 |
| Ackermann, S; Althoff, K; Astrahantseff, K; Batzke, K; Deubzer, HE; Eggert, A; Fischer, M; Heukamp, L; Künkele, A; Lindner, S; Odersky, A; Pajtler, KW; Sadowski, N; Schäfers, S; Schönbeck, K; Schramm, A; Schulte, JH; Sprüssel, A; Thor, T | 1 |
| Chen, C; Cui, P; Ju, S; Liao, Y; Rui, R; Yao, L; Zhang, Y; Zhang, Z | 1 |
| Lee, YJ; Shin, SB; Woo, SU; Yim, H | 1 |
| Abbasi, B; Chen, C; Cui, P; Dong, Y; Ju, S; Liao, Y; Lin, D; Rui, R; Zhang, Y; Zhang, Z | 1 |
| Ali, S; Buluwela, L; Farzan, R; Meek, DW; Saurin, AT; Smith, L | 1 |
| Brassesco, MS; Pezuk, JA; Roberto, GM; Salomão, KB; Scrideli, CA; Tone, LG | 1 |
| Chou, TC; Huang, YT; Lin, JD; Lin, SF; Wong, RJ; Yeh, CN | 1 |
| Backes, D; Dickhöfer, S; El Maadidi, S; Franz-Wachtel, M; Garcia, MD; Gay, NJ; Klimosch, SN; Liu, X; Macek, B; Motshwene, P; Schüssler, JM; Soufi, B; Taumer, C; Wang, H; Weber, ANR; Wolz, OO | 1 |
| Armeson, K; Britten, C; Erlander, M; Ethier, S; Giordano, A; Kappler, C; Liu, Y; Park, Y; Reuben, J; Ridinger, M; Yeh, E | 1 |
| Chen, Q; Fukagawa, T; Huang, J; Lu, W; Pan, X; Wang, F; Xu, J; Yan, H; Yan, L; Yang, B; Yuan, X; Zeng, LH; Zhang, L; Zhang, M; Zhou, L | 1 |
| Haji, K; Imakura, T; Ishizawa, K; Kagawa, K; Kawano, H; Koyama, K; Murakami, K; Naito, N; Niimura, T; Nishioka, Y; Ogawa, H; Sato, S; Yamashita, Y; Zamami, Y | 1 |
1 trial(s) available for thiophenes and gsk 461364
| Article | Year |
|---|---|
Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzimidazoles; Binding, Competitive; Cell Cycle Proteins; Colorectal Neoplasms; Disease Progression; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Substrate Specificity; Thiophenes | 2011 |
19 other study(ies) available for thiophenes and gsk 461364
| Article | Year |
|---|---|
Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).
Topics: Apoptosis; Benzimidazoles; Biomarkers, Pharmacological; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Humans; Lung Neoplasms; Microarray Analysis; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Retinoids; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiophenes | 2011 |
A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Screening Assays, Antitumor; Glioblastoma; Humans; Indans; Mice; Mice, Knockout; Neoplastic Stem Cells; Neural Stem Cells; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; Small Molecule Libraries; Swine; Thiophenes; Tumor Suppressor Protein p53 | 2013 |
BI 6727 and GSK461364 suppress growth and radiosensitize osteosarcoma cells, but show limited cytotoxic effects when combined with conventional treatments.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Bone Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; Osteosarcoma; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Radiation Tolerance; Radiation-Sensitizing Agents; Thiophenes | 2015 |
Overexpression of human ABCB1 in cancer cells leads to reduced activity of GSK461364, a specific inhibitor of polo-like kinase 1.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Benzimidazoles; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Humans; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Thiophenes | 2014 |
Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Benzimidazoles; Benzoates; Benzoquinones; Binding Sites; Catalytic Domain; Cell Cycle Proteins; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Drug Design; Female; G2 Phase Cell Cycle Checkpoints; HeLa Cells; Humans; Inhibitory Concentration 50; Mitosis; Molecular Targeted Therapy; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Pteridines; Quinones; S Phase Cell Cycle Checkpoints; Signal Transduction; Thiophenes; Time Factors; Uterine Cervical Neoplasms | 2015 |
Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer.
Topics: Animals; Apoptosis; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Chromosomal Instability; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Mice; Mutation; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pteridines; Thiophenes; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Cytotoxic mechanism of PLK1 inhibitor GSK461364 against osteosarcoma: Mitotic arrest, apoptosis, cellular senescence, and synergistic effect with paclitaxel.
Topics: Adenosine Triphosphate; Apoptosis; Benzimidazoles; beta-Galactosidase; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Computational Biology; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Humans; Mitosis; Oligonucleotide Array Sequence Analysis; Osteoblasts; Osteosarcoma; Paclitaxel; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Small Interfering; Thiophenes | 2016 |
Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Blotting, Western; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Cyclin B1; Cyclin-Dependent Kinases; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Phosphorylation; Polo-Like Kinase 1; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Real-Time Polymerase Chain Reaction; Retinal Neoplasms; Retinoblastoma; Thiophenes; Tumor Cells, Cultured | 2017 |
The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Gene Dosage; Humans; Inhibitory Concentration 50; Mice, Nude; N-Myc Proto-Oncogene Protein; Neuroblastoma; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Signal Transduction; Thiophenes; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Plk1 inhibition leads to a failure of mitotic division during the first mitotic division in pig embryos.
Topics: Animals; Benzimidazoles; Cell Cycle; Cell Cycle Proteins; Chromosome Aberrations; Embryo, Mammalian; Gene Expression Regulation, Developmental; Mitosis; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Spindle Apparatus; Swine; Thiophenes; Tubulin | 2017 |
Comparative Analysis of a FRET-based PLK1 Kinase Assay to Identify PLK1 inhibitors for Chemotherapy.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Biological Assay; Biomarkers, Tumor; Cell Cycle Proteins; Drug Evaluation, Preclinical; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Genistein; Glutathione Transferase; Humans; Insecta; Peptides; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Radioisotopes; Thiophenes; Tumor Protein, Translationally-Controlled 1 | 2017 |
Polo-like kinase 1 inhibition results in misaligned chromosomes and aberrant spindles in porcine oocytes during the first meiotic division.
Topics: Animals; Benzimidazoles; Cell Culture Techniques; Cell Cycle Proteins; Chromosome Aberrations; Cytoplasmic Vesicles; Female; Meiosis; Oocytes; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Spindle Apparatus; Swine; Thiophenes; Tubulin | 2018 |
The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.
Topics: Benzimidazoles; Cell Cycle Proteins; Cell Survival; Centrosome; Fluorescent Antibody Technique; Gene Silencing; HCT116 Cells; Humans; Mitosis; Morpholines; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pyrazines; Pyrones; Sulfones; Thiophenes; Tumor Suppressor Protein p53 | 2017 |
PLK1 Inhibition Radiosensitizes Breast Cancer Cells, but Shows Low Efficacy as Monotherapy or in Combination with other Cytotoxic Drugs.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Radiation-Sensitizing Agents; Thiophenes | 2018 |
Targeting PLKs as a therapeutic approach to well-differentiated thyroid cancer.
Topics: Adenocarcinoma, Follicular; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzimidazoles; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Female; Humans; Mice; Mice, Nude; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Sorafenib; Thiophenes; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2019 |
Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells.
Topics: Benzimidazoles; Binding Sites; Cell Cycle Proteins; Cytokines; Gene Expression; HEK293 Cells; Humans; Interleukin-1 Receptor-Associated Kinases; Monocytes; Phosphorylation; Polo-Like Kinase 1; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Signal Transduction; Thiophenes; THP-1 Cells; Toll-Like Receptors | 2019 |
Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Cell Cycle Proteins; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Mice; Piperazines; Polo-Like Kinase 1; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pyrazoles; Quinazolines; Thiophenes; Triple Negative Breast Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2019 |
Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation.
Topics: Aurora Kinase B; Benzimidazoles; Cell Cycle Proteins; Centromere; Chromosome Segregation; CRISPR-Cas Systems; HeLa Cells; Histones; Humans; Kinetochores; Microscopy, Fluorescence; Microtubules; Polo-Like Kinase 1; Poly-ADP-Ribose Binding Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA Interference; RNA, Guide, Kinetoplastida; RNA, Small Interfering; Thiophenes; Time-Lapse Imaging | 2021 |
A polo-like kinase inhibitor identified by computational repositioning attenuates pulmonary fibrosis.
Topics: Animals; Benzimidazoles; Bleomycin; Drug Repositioning; Fibroblasts; Idiopathic Pulmonary Fibrosis; Lung; Mice; Thiophenes | 2023 |