thiophenes has been researched along with gs-9669 in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Appleby, TC; Bidgood, AM; Byun, D; Canales, E; Clarke, MO; Doerffler, E; Eng, S; Fenaux, M; Hashash, A; Krawczyk, SH; Lazerwith, SE; Leavitt, SA; Lee, YJ; Lew, W; Liu, Q; Mabery, EM; Matles, M; Mertzman, M; Morganelli, P; Murray, BP; Mwangi, J; Tian, Y; Watkins, WJ; Xu, L; Ye, H; Zhang, J | 1 |
| Appleby, T; Byun, D; Canales, E; Chen, X; Chong, L; Clarke, MO; Doerffler, E; Fenaux, M; Hashash, A; Lazerwith, SE; Leavitt, SA; Lee, YJ; Lew, W; Liu, Q; Mabery, E; Matles, M; Mertzman, M; Morganelli, P; Murray, BP; Mwangi, JW; Tian, Y; Watkins, WJ; Xu, L; Ye, H; Zhang, J; Zhu, C | 1 |
| Ding, X; Gane, EJ; Hyland, RH; McHutchison, JG; Pang, PS; Stedman, CA; Subramanian, GM; Svarovskaia, E; Symonds, WT | 1 |
| Appleby, T; Barauskas, O; Boyce, SE; Fenaux, M; Hung, M; Kan, E; Lagpacan, L; Niedziela-Majka, A; Perry, J; Sakowicz, R; Schmitz, U; Tirunagari, N; Watkins, WJ; Wong, M | 1 |
| Borgia, G; Buonomo, AR; Coppola, N; Gentile, I; Zappulo, E | 1 |
| Delaney, W; Dvory-Sobol, H; Lawitz, EJ; Mabery, E; McHutchison, J; Miller, MD; Mo, H; Skurnac, T; Svarovskaia, ES; Voitenleitner, C | 1 |
| Foster, GR | 1 |
| Abbott, S; Barrett, LL; Bon, D; Chavez, J; Diaz, G; Egerson, D; Fauci, AS; Gross, C; Herrmann, E; Jolley, TA; Kapoor, R; Kleiner, DE; Kohli, A; Kotb, C; Kottilil, S; Kwan, R; Marti, MM; Masur, H; McHutchison, J; Meissner, EG; Nelson, A; Osinusi, A; Pang, PS; Petersen, T; Polis, MA; Proschan, M; Sidharthan, S; Silk, R; Sims, Z; Sneller, M; Spurlin, E; Subramanian, GM; Symonds, WT; Talwani, R; Teferi, G; Townsend, K; Wood, BJ | 1 |
| Kohli, A; Kottilil, S; Masur, H; Meissner, EG; Osinusi, A; Remaley, AT; Sampson, M; Sidharthan, S; Tang, L; Townsend, K | 1 |
| Abbott, S; Akoth, E; Chavez, J; Emmanuel, B; Gross, C; Jolley, TA; Kattakuzhy, S; Kohli, A; Kottilil, S; Masur, H; McLaughlin, M; Meissner, EG; Mo, H; Nelson, A; Osinusi, A; Polis, MA; Price, A; Proschan, M; Seamon, C; Sidharthan, S; Silk, R; Sims, Z; Tang, L; Teferi, G; Wilson, E | 1 |
| Deredge, D; Johnson, KA; Li, J; Wintrode, PL | 1 |
| Guedj, J; Kohli, A; Kottilil, S; Nguyen, THT; Perelson, AS; Uprichard, SL | 1 |
| Bagchi, S; Kottilil, S; Nelson, A; Poonia, B; Romani, S; Stafford, K | 1 |
1 review(s) available for thiophenes and gs-9669
| Article | Year |
|---|---|
GS-9669: a novel non-nucleoside inhibitor of viral polymerase for the treatment of hepatitis C virus infection.
Topics: Antiviral Agents; Clinical Trials as Topic; DNA-Directed RNA Polymerases; Drug Resistance, Viral; Furans; Hepacivirus; Hepatitis C; Humans; Thiophenes; Viral Proteins | 2014 |
8 trial(s) available for thiophenes and gs-9669
| Article | Year |
|---|---|
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Dogs; Drug Resistance, Viral; Furans; Hepacivirus; Humans; Interferon-alpha; Male; Mutation; Polymorphism, Single Nucleotide; Pyrones; Rats; Rats, Sprague-Dawley; Ribavirin; RNA-Dependent RNA Polymerase; Thiophenes; Triazoles; Viral Nonstructural Proteins | 2013 |
Efficacy of nucleotide polymerase inhibitor sofosbuvir plus the NS5A inhibitor ledipasvir or the NS5B non-nucleoside inhibitor GS-9669 against HCV genotype 1 infection.
Topics: Adult; Aged; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Enzyme Inhibitors; Fatigue; Female; Fluorenes; Furans; Genotype; Headache; Hepacivirus; Hepatitis C; Humans; Incidence; Male; Middle Aged; Nausea; Sofosbuvir; Thiophenes; Treatment Outcome; Uridine Monophosphate; Viral Nonstructural Proteins | 2014 |
Clinical and in vitro resistance to GS-9669, a thumb site II nonnucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Topics: Adult; Antiviral Agents; Base Sequence; Benzimidazoles; Cell Line; Drug Resistance, Viral; Female; Fluorenes; Furans; Genetic Variation; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Microbial Sensitivity Tests; Molecular Sequence Data; Protein Binding; Quinolines; Ribavirin; Sequence Analysis, RNA; Sofosbuvir; Thiophenes; Treatment Outcome; Uridine Monophosphate; Viral Nonstructural Proteins | 2014 |
Virological response after 6 week triple-drug regimens for hepatitis C: a proof-of-concept phase 2A cohort study.
Topics: Aged; Antiviral Agents; Benzimidazoles; Cohort Studies; Drug Therapy, Combination; Female; Fluorenes; Furans; Hepacivirus; Hepatitis C, Chronic; Humans; Intention to Treat Analysis; Male; Middle Aged; Quinolines; Ribavirin; RNA, Viral; Sofosbuvir; Thiophenes; Treatment Outcome; Uridine Monophosphate; Viral Load | 2015 |
Interferon-Free Treatment of Hepatitis C Virus in HIV/Hepatitis C Virus-Coinfected Subjects Results in Increased Serum Low-Density Lipoprotein Concentration.
Topics: Antiviral Agents; Benzimidazoles; Cardiovascular Diseases; Cholesterol, LDL; Coinfection; Drug Therapy, Combination; Dyslipidemias; Female; Fluorenes; Furans; Hepacivirus; Hepatitis C, Chronic; HIV Infections; HIV-1; Humans; Male; Middle Aged; Prospective Studies; Quinolines; Ribavirin; Sofosbuvir; Thiophenes; Uridine Monophosphate | 2016 |
Four-Week Direct-Acting Antiviral Regimens in Noncirrhotic Patients With Hepatitis C Virus Genotype 1 Infection: An Open-Label, Nonrandomized Trial.
Topics: Antiviral Agents; Benzimidazoles; Drug Resistance, Viral; Drug Therapy, Combination; Female; Fluorenes; Furans; Genotype; Hepatitis C; Hepatitis C, Chronic; Humans; Male; Middle Aged; Quinolines; RNA, Viral; Sofosbuvir; Thiophenes; Treatment Outcome; Viral Load | 2015 |
The paradox of highly effective sofosbuvir-based combination therapy despite slow viral decline: can we still rely on viral kinetics?
Topics: Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Fluorenes; Furans; Hepacivirus; Hepatitis C, Chronic; Humans; Kinetics; Male; Models, Theoretical; Quinolines; Sofosbuvir; Sustained Virologic Response; Thiophenes; Treatment Outcome; Uridine Monophosphate; Viral Load | 2017 |
Peripheral PD-1
Topics: Adult; Antiviral Agents; Benzimidazoles; CD8-Positive T-Lymphocytes; Cytokines; Drug Therapy, Combination; Female; Fluorenes; Furans; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Middle Aged; Pilot Projects; Programmed Cell Death 1 Receptor; Quinolines; Receptors, Immunologic; Sofosbuvir; Sustained Virologic Response; T-Lymphocytes; Thiophenes; Viral Load | 2019 |
4 other study(ies) available for thiophenes and gs-9669
| Article | Year |
|---|---|
Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.
Topics: Antiviral Agents; Enzyme Inhibitors; Furans; Magnetic Resonance Spectroscopy; Models, Molecular; Thiophenes; Viral Nonstructural Proteins | 2014 |
Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.
Topics: Allosteric Site; Amino Acid Motifs; Catalytic Domain; Enzyme Inhibitors; Enzyme Stability; Furans; Hepacivirus; Models, Molecular; Sequence Deletion; Thiophenes; Viral Nonstructural Proteins | 2014 |
Shorter treatments for hepatitis C: another step forward?
Topics: Antiviral Agents; Benzimidazoles; Female; Fluorenes; Furans; Hepatitis C, Chronic; Humans; Male; Quinolines; Ribavirin; RNA, Viral; Sofosbuvir; Thiophenes; Uridine Monophosphate | 2015 |
Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase.
Topics: Allosteric Regulation; Binding Sites; Deuterium Exchange Measurement; Furans; Hepacivirus; Kinetics; Pyrones; RNA-Dependent RNA Polymerase; RNA, Viral; Thiophenes; Triazoles; Viral Nonstructural Proteins | 2016 |