thiophenes has been researched along with glycine in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (30.43) | 18.7374 |
| 1990's | 13 (18.84) | 18.2507 |
| 2000's | 16 (23.19) | 29.6817 |
| 2010's | 17 (24.64) | 24.3611 |
| 2020's | 2 (2.90) | 2.80 |
| Authors | Studies |
|---|---|
| Arrigoni Martelli, E; Bruno, G; Chassard, D; Douin, MJ; Giubilei, C; Marzo, A; Mignot, A; Nava, D; Thebault, JJ | 1 |
| Brooks, DP; Wang, YX | 1 |
| Arrigoni Martelli, E; Bruno, G; Lefebvre, MA; Marzo, A; Mignot, A; Nava, D; Vidal, R | 1 |
| Allocca, F; Antenora, G; Assunto, A; Bossone, V; De Rensis, L; Schianchi, L | 1 |
| Bénavidès, J; Carter, C; Rivy, JP; Scatton, B | 1 |
| Cooper, RD; Draheim, SE; Graves, BJ; Holmes, RE; Huffman, GW; Kinnick, MD; Kukolja, S; Neel, DA; Pfeil, JL; Webber, JA | 1 |
| Draheim, SE; Kukolja, S; Ott, JL; Pfeil, JL | 1 |
| Barbieri, P; Gaiani, P; Guslandi, M; Nannini, D | 1 |
| Allegra, L; Bossi, R; Braga, PC | 1 |
| Ardizzi, A; Della Toffola, A; Galietti, F; Giorgis, GE; Miravalle, C; Oliaro, A; Scappaticci, E | 1 |
| Cooper, RD; Counter, FT; Draheim, SE; Graves, BJ; Hunden, DC; Kukolja, S; Ott, JL; Pfeil, JL | 1 |
| Barrett-Bee, K; Cox, A; Davis, SS; Marriott, C; Readman, AS | 1 |
| Duranti, L; Galmuzzi, G; Lisciani, R; Oriani, G; Zeuli, L | 1 |
| Hatanaka, M; Ishimaru, T | 1 |
| Bamgbose, SO | 1 |
| Hirose, S; Iida, K; Inada, Y; Tamaura, Y | 1 |
| Bousquet, E; Fiumara, A; Guarcello, V; Matera, M; Morale, MC; Rizza, V | 1 |
| Radice, G; Rugarli, G | 1 |
| Andreoni, G; Bosio, G; Bramato, C; Magliocca, R; Salassa, B | 1 |
| Acone, A; Ciani, A; Dotta, F; Nava, D | 1 |
| Bruno, M; Fruttero, B; Linari, F; Marangella, M | 1 |
| Gnemi, P; Mondino, A; Segre, G; Silvestri, S; Zanolo, G | 1 |
| Di Blasio, P; Gasparini Cesari, M; Palmieri, B | 1 |
| Casaretti, L; Magliocca, R | 1 |
| Boraldi, F; Palmieri, B | 1 |
| Arrigoni-Martelli, E; de Giorgi, L; Matossian-Rogers, A | 1 |
| Sasaki, T; Satoh, M; Shimura, S; Shirato, K; Takishima, T; Yamada, K | 1 |
| di Fonso, M; Pietrantonio, F; Pocobelli, D; Romano, A; Venuti, A | 1 |
| Glofcheski, DJ; Kruuv, J | 1 |
| Hanley, MR; Kim, HY; Thomas, D | 1 |
| Di Fonso, M; Giuffreda, F; Mormile, F; Quaratino, D; Romano, A; Venuti, A | 1 |
| Battaglia, G; Bruno, V; Catania, MV; Di Grezia, R; Kingston, A; Nicoletti, F; O'Neill, MJ | 1 |
| Broadhurst, K; Carminati, P; de Giorgi, L; Habeshaw, JA; Oxford, JS | 1 |
| Battaglia, G; Bond, A; Bruno, V; Clark, BP; Harris, JR; Kingston, AE; Lodge, D; Monn, JA; Nicoletti, F; O'Neill, MJ; Schoepp, DD | 1 |
| Brady, CS; FitzGerald, MX; Mackarel, AJ; O'Connor, CM; Russell, KJ | 1 |
| Bellomo, M; Catania, MV; De Blasi, A; Di Giorgi-Gerevini, V; Giuffrida, R; Nicoletti, F; Romeo, R; Seminara, G | 1 |
| Baker, RS; Chamberlain, MJ; Clark, BP; Griffey, K; Harris, JR; Johnson, BG; Johnson, MP; Kelly, G; Kingston, AE; Schoepp, DD; Tizzano, JT; Tomlinson, R; Wright, RA | 1 |
| Napoli, C | 1 |
| Camaioni, E; Cavanni, P; Costantino, G; Faedo, S; Marinozzi, M; Micheli, F; Moroni, F; Natalini, B; Noe, C; Pellicciari, R; Sarichelou, I | 1 |
| Jong, YJ; Kingston, AE; Kumar, V; O'Malley, KL; Romano, C | 1 |
| Berger, ML; Buchstaller, HP; Frank, I; Gottschlich, R; Krug, M; Leibrock, J; Noe, CR; Siebert, CD; Steinhilber, D; Steinmetz, R | 1 |
| Hampton, T | 1 |
| Chattopadhyay, S; Goldman, ID; Krupenko, N; Krupenko, SA; Zhao, R | 1 |
| Turpie, AG | 1 |
| Baker, S; Brioni, JD; Chang, R; EI-Kouhen, O; Gauvin, DM; Hernandez, G; Hollingsworth, PR; Honore, P; Lehto, SG; Moreland, RB; Stewart, AO; Zheng, G; Zhu, CZ | 1 |
| Harenberg, J; Wehling, M | 1 |
| Altamura, M; D'Andrea, P; Ettorre, A; Fattori, D; Giuliani, S; Madami, A; Meini, S; Porcelloni, M; Rossi, C; Sisto, A | 1 |
| Ayscough, A; Bawden, LJ; Bone, EA; Box, G; Callaghan, J; Chandler, S; Clark, VL; Drummond, AH; Eccles, SA; Farmer, H; Flores, N; Kirwin-Jones, P; Krige, D; Laber, D; Legris, V; Miles, LE; Needham, LA; Odedra, R; Owen, J; Patel, T; Stone, E; Wood, LM; Wood, S; Wright, A | 1 |
| Charbonnel, B | 1 |
| Perzborn, E | 1 |
| Collins, JL; Grant, D; Joshi, S; Lazar, MA; Orband-Miller, LA; Parks, DJ; Willson, TM; Wisely, GB; Yin, L; Zuercher, WJ | 1 |
| Raman, IM; Zheng, N | 1 |
| Chen, H; Chu, G; Hashimoto, S; Hattori, MA; Shigeyoshi, Y; Yamauchi, N; Zhao, L | 1 |
| Chiarugi, A; Formentini, L; Gerace, E; Landucci, E; Moroni, F; Pellegrini-Giampietro, DE; Scartabelli, T | 1 |
| Chen, L; Chen, S; He, Q; Hou, J; Liu, J; Nie, Z; Wang, J; Xiong, S; Yang, G | 1 |
| Farkouh, M; Plutzky, J; Rosenson, RS; Wright, RS | 1 |
| Blaikley, J; Boudjelal, M; Bresciani, S; Cooper, AW; Dawson, HC; Farrow, SN; Grant, D; Kashatus, JA; Loudon, A; Orband-Miller, LA; Ray, D; Tellam, JP; Tomkinson, NC; Trump, RP; Willson, TM; Wojno, J | 1 |
| Burris, TP; Fernandez-Ruiz, R; Figueroa, AL; Gomis, R; Marroquí, L; Merino, B; Nadal, A; Quesada, I; Vieira, E | 1 |
| Imaizumi, K; Izawa, T; Kizaki, T; Ogasawara, J; Ohno, H; Sakurai, T; Sato, S; Takahashi, M; Taniguchi, N | 1 |
| Chen, H; Hashimoto, S; Hattori, MA; Isayama, K; Kumazawa, M; Shigeyoshi, Y; Yamauchi, N; Zhao, L | 1 |
| Aquino, TM; Araújo-Júnior, JX; Barreto, EO; Bortoluzzi, JH; Ferreira, RS; França, PHB; Gatto, CC; Lima, MCA; Mendonça-Júnior, FJB; Meneghetti, MR; Moreira, DRM; Scotti, L; Scotti, MT; Silva, EB; Silva, EPS; Silva, JPN; Silva-Júnior, EF; Siqueira-Neto, JL | 1 |
| Rahman, I; Rashid, K; Sellix, MT; Sundar, IK | 1 |
| Batista, TM; Borck, PC; Boschero, AC; Camargo, RL; Carneiro, EM; Vettorazzi, JF; Vieira, E | 1 |
| Guo, DK; Hao, ZB; Mu, CC; Ren, HG; Sun, HY; Wang, GH; Xu, XY; Zhang, S; Zhu, Y | 1 |
| Hisaoka-Nakashima, K; Kodama, K; Morioka, N; Nakamura, Y; Nakata, Y; Saeki, M; Tomori, M; Yoshikawa, K; Zhang, FF | 1 |
| Fang, X; Gao, J; Ge, Y; Huang, T; Li, Y; Xiao, H; Xu, Y; Yu, D; Zhang, Y; Zong, L | 1 |
| Chu, G; Hu, Y; Shi, S; Yang, G; Zhou, X | 1 |
| Drosatos, K; Kalliora, C | 1 |
| Fan, K; Jiang, R; Li, L; Liu, G; Shao, R; Shen, Y; Tang, L; Wu, X; Yang, Y; Zhang, L | 1 |
4 review(s) available for thiophenes and glycine
| Article | Year |
|---|---|
Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases.
Topics: Administration, Oral; Animals; Anticoagulants; Blood Coagulation; Drugs, Investigational; Factor Xa; Factor Xa Inhibitors; Glycine; Humans; Morpholines; Piperazines; Rivaroxaban; Thiophenes; Thromboembolism; Treatment Outcome | 2007 |
Current and future prospects for anticoagulant therapy: inhibitors of factor Xa and factor IIa.
Topics: Acute Coronary Syndrome; Administration, Oral; Anticoagulants; Atrial Fibrillation; Azetidines; Benzimidazoles; Benzylamines; Clinical Trials as Topic; Dabigatran; Factor Xa Inhibitors; Glycine; Humans; Infusions, Parenteral; Morpholines; Oligosaccharides; Piperazines; Prothrombin; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiophenes; Thrombin; Thrombosis; Venous Thromboembolism | 2008 |
Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects.
Topics: Alkanesulfonates; Diabetic Angiopathies; Glycine; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Oxazines; Oxazoles; Phenylpropionates; Phosphorylation; PPAR alpha; PPAR delta; PPAR gamma; Thiazolidinediones; Thiophenes; United States; United States Food and Drug Administration | 2012 |
The Glitazars Paradox: Cardiotoxicity of the Metabolically Beneficial Dual PPARα and PPARγ Activation.
Topics: Alkanesulfonates; Animals; Cardiotoxicity; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Energy Metabolism; Glycine; Humans; Hypoglycemic Agents; Oxazoles; Phenylpropionates; PPAR alpha; PPAR gamma; Risk Assessment; Risk Factors; Signal Transduction; Thiophenes | 2020 |
5 trial(s) available for thiophenes and glycine
| Article | Year |
|---|---|
Pharmacokinetics of 2-(alpha-thenoylthio)-propionylglycine (TTPG) in healthy volunteers--an oral dose-proportionality investigation.
Topics: Adult; Carboxylic Acids; Chromatography, High Pressure Liquid; Expectorants; Female; Glycine; Half-Life; Humans; Male; Spectrophotometry, Ultraviolet; Sulfides; Thiophenes; Tiopronin | 1992 |
[A controlled clinical study on the efficacy and tolerability of stepronin in chronic alcoholic liver diseases].
Topics: Adult; Aged; Drug Tolerance; Female; Glycine; Humans; Liver Diseases, Alcoholic; Male; Middle Aged; Sulfides; Thiophenes; Time Factors | 1990 |
Rheological modifications of mucus in chronic bronchitic patients after treatment with stepronine-lysine salt.
Topics: Adult; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Elasticity; Expectorants; Glycine; Humans; Middle Aged; Random Allocation; Rheology; Sputum; Sulfides; Thiophenes; Viscosity | 1987 |
[Efficacy of the simultaneous aerosol administration of fenoterol and 2(alpha-thenoylthio)propionylglycine].
Topics: Aerosols; Aged; Clinical Trials as Topic; Double-Blind Method; Expectorants; Female; Fenoterol; Forced Expiratory Volume; Glycine; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Sputum; Sulfides; Thiophenes; Time Factors; Viscosity | 1986 |
[The therapeutic activity of stepronin in viral hepatitis].
Topics: Adolescent; Adult; Aged; Bilirubin; Child; Clinical Trials as Topic; Female; Glucose; Glycine; Hepatitis, Viral, Human; Humans; Male; Middle Aged; Sulfides; Thiophenes; Transaminases | 1982 |
60 other study(ies) available for thiophenes and glycine
| Article | Year |
|---|---|
Renin-angiotensin system inhibition reduces glycine-induced glomerular hyperfiltration in conscious rats.
Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Enalapril; Glomerular Filtration Rate; Glycine; Imidazoles; Infusions, Intravenous; Male; Rats; Rats, Inbred Strains; Renal Circulation; Renin-Angiotensin System; Thiophenes | 1992 |
High-performance liquid chromatographic evaluation of 2-(alpha-thenoylthio)propionylglycine and its two metabolites in biological fluids.
Topics: Chromatography, High Pressure Liquid; Glycine; Humans; Reference Values; Spectrophotometry, Ultraviolet; Sulfides; Thiophenes | 1991 |
Differential modulation of [3H]TCP binding to the NMDA receptor by L-glutamate and glycine.
Topics: Animals; Brain Chemistry; Glutamates; Glycine; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thiophenes | 1988 |
Orally absorbable cephalosporin antibiotics. 1. Structure-activity relationships of benzothienyl- and naphthylglycine derivatives of 7-aminodeacetoxycephalosporanic acid.
Topics: Administration, Oral; Cephalexin; Cephalosporins; Chemical Phenomena; Chemistry; Glycine; Gram-Positive Bacteria; Haemophilus influenzae; Naphthalenes; Staphylococcus; Stereoisomerism; Streptococcus; Structure-Activity Relationship; Thiophenes | 1985 |
Orally absorbable cephalosporin antibiotics. 3. Preparation of biologically active R isomer of 7-(3-benzothienylglycylamido)deacetoxycephalosporanic acid.
Topics: Administration, Oral; Cephalosporins; Chemical Phenomena; Chemistry; Glycine; Gram-Positive Bacteria; Haemophilus influenzae; Staphylococcus; Stereoisomerism; Streptococcus pneumoniae; Streptococcus pyogenes; Structure-Activity Relationship; Thiophenes | 1985 |
Noninvolvement of gastric mucus in the mucolytic effect of stepronine lysine salt.
Topics: Adolescent; Adult; Expectorants; Female; Gastric Mucosa; Glycine; Humans; Male; Middle Aged; Mucus; Sulfides; Thiophenes | 1988 |
Orally absorbable cephalosporin antibiotics. 2. Structure-activity studies of bicyclic glycine derivatives of 7-aminodeacetoxycephalosporanic acid.
Topics: Administration, Oral; Animals; Cephalexin; Cephalosporins; Chemical Phenomena; Chemistry; Glycine; Gram-Positive Bacteria; Haemophilus influenzae; Indoles; Mice; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus; Structure-Activity Relationship; Thiophenes | 1985 |
A new mucotropic agent--in vitro and in vivo evaluation of 2-alpha-thenoylthiopropionylglycine (bronchoplus).
Topics: Acetylcysteine; Animals; Dithiothreitol; Expectorants; Glycine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Models, Biological; Mucus; Rheology; Sulfides; Swine; Swine, Miniature; Thiophenes; Time Factors; Viscosity | 1985 |
Gastrointestinal absorption of 2-(alpha-thenoylthio)propionylglycine (TTPG) in healthy volunteers: a comparative study between two different pharmaceutical forms.
Topics: Adult; Antiviral Agents; Female; Glycine; Humans; Intestinal Absorption; Male; Middle Aged; Solutions; Sulfides; Tablets; Thiophenes | 1985 |
Synthetic penicillins. Heterocyclic analogs of ampicillin. Structure-activity relationships.
Topics: Ampicillin; Bacillus subtilis; Chromatography, Paper; Escherichia coli; Glycine; Microbial Sensitivity Tests; Penicillins; Salmonella enteritidis; Shigella dysenteriae; Spectrophotometry, Infrared; Staphylococcus; Structure-Activity Relationship; Thiazoles; Thiophenes | 1973 |
Antagonism of the trypanocide, berenil, and the nematocide, morantel, by tubocurarine.
Topics: Acetylcholine; Amidines; Animals; Antinematodal Agents; Anura; Glycine; Muscle Contraction; Pyrimidines; Thiophenes; Triazenes; Trypanocidal Agents; Tubocurarine | 1973 |
Energy-linked conformational change of the mitochondrial membrane measured with the NH2-modifying reagent, acrolein.
Topics: Acrolein; Aldehydes; Amines; Amino Acids; Animals; Antimycin A; Azides; Butanones; Calcium; Chelating Agents; Energy Transfer; Glycine; Hydrogen-Ion Concentration; Membranes; Mitochondria; Mitochondria, Liver; Molecular Conformation; Oligomycins; Oxygen Consumption; Protein Binding; Rats; Thiophenes | 1973 |
The effects of 2-(alpha-Tenoyl) thiopropionylglycine (TTPG) on human lung mucus.
Topics: Centrifugation, Density Gradient; Expectorants; Glycine; Humans; Lung; Microsomes; Mucus; Solubility; Sulfides; Thiolester Hydrolases; Thiophenes | 1983 |
[Effect of stepronin on alcohol metabolism. An experimental study in the rabbit].
Topics: Alcohol Oxidoreductases; Animals; Carbon Tetrachloride Poisoning; Ethanol; Glycine; In Vitro Techniques; Liver; Rabbits; Sulfides; Thiophenes; Time Factors | 1982 |
[Efficacy of mucotropic agents in the treatment of bronchial asthma. Preliminary study of 2-(alpha-thenoylthio)-propionylglycine].
Topics: Adult; Asthma; Drug Evaluation; Expectorants; Female; Glycine; Humans; Male; Middle Aged; Sulfides; Thiophenes | 1983 |
[Cystinuria: clinical and therapeutic aspects].
Topics: Adolescent; Adult; Aged; Child; Cystinuria; Drug Evaluation; Glycine; Humans; Kinetics; Middle Aged; Penicillamine; Sulfides; Thiophenes; Tiopronin | 1982 |
[Serum kinetics and biotransformation of prostenoglycine in the rat, dog and monkey].
Topics: Animals; Biotransformation; Dogs; Glycine; Macaca fascicularis; Rats; Species Specificity; Sulfides; Thiophenes | 1981 |
[Protective action of prostenoglycine in in-vitro experimental erythrocyte poisoning].
Topics: Erythrocytes; Glycine; In Vitro Techniques; Phenylhydrazines; Sulfhydryl Compounds; Sulfides; Thiophenes | 1981 |
[Mechanism of hepatocyte-protective action of prostenoglycine].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Glycine; Liver; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Sulfides; Thiophenes | 1981 |
[Changes in the hepatocyte concentration of glutathione after administration of stepronin. Histochemical study].
Topics: Adult; Female; Glutathione; Glycine; Histocytochemistry; Humans; Liver; Male; Middle Aged; Sulfides; Thiophenes | 1981 |
Immunosuppressive effect of stepronin (TS-5010680) in mice.
Topics: Animals; Cells, Cultured; Concanavalin A; Glycine; Graft vs Host Disease; Immunosuppressive Agents; Lymph Nodes; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocyte Transfusion; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Skin Transplantation; Spleen; Sulfides; Thiophenes; Transplantation, Homologous | 1994 |
An expectorant, stepronin, reduces airway secretion in vitro.
Topics: Amiloride; Animals; Cats; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Epithelium; Expectorants; Female; Glycine; Indomethacin; Isoproterenol; Male; Membrane Potentials; Mucus; Structure-Activity Relationship; Sulfides; Thiophenes; Trachea | 1994 |
Delayed hypersensitivity to stepronin: a case report.
Topics: Aerosols; Aged; Bronchial Provocation Tests; Drug Eruptions; Expectorants; Facial Dermatoses; Female; Glycine; Humans; Hypersensitivity, Delayed; Intradermal Tests; Lung Diseases, Obstructive; Sulfides; Thiophenes | 1993 |
Further evidence for two modes of hypothermia damage.
Topics: Adenosine; Animals; Cell Death; Cell Division; Cell Line; Cell Survival; Cold Temperature; Cricetinae; Cricetulus; Cryopreservation; Cryoprotective Agents; Glycine; Thermodynamics; Thiophenes; Thiourea; Time Factors | 1993 |
Stimulation of Ca(2+)-dependent membrane currents in Xenopus oocytes by microinjection of pyrimidine nucleotide-glucose conjugates.
Topics: Adenosine Diphosphate Glucose; Animals; Calcium; Cell Membrane; Chelating Agents; Egtazic Acid; Female; Glucose; Glycine; Guanosine Diphosphate Sugars; Inositol 1,4,5-Trisphosphate; Kinetics; Membrane Potentials; Microinjections; Nucleoside Diphosphate Sugars; Oocytes; Sulfides; Thiophenes; Uridine Diphosphate Glucose; Xenopus | 1996 |
Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: a case report.
Topics: Administration, Inhalation; Adult; Bronchial Spasm; Drug Eruptions; Expectorants; Glycine; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Male; Respiratory Hypersensitivity; Sulfides; Thiophenes | 1996 |
Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept
Topics: Animals; Astrocytes; Benzoates; Caudate Nucleus; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Fetus; Gerbillinae; Glycine; Ischemic Attack, Transient; Male; Mice; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiophenes | 1999 |
Anti-human immunodeficiency virus activity of a new immunosuppressant drug called stepronin.
Topics: Anti-HIV Agents; Cell Survival; Cells, Cultured; Glycine; HIV-1; Humans; Immunosuppressive Agents; Lymphocytes; Sulfides; Thiophenes; U937 Cells; Virus Replication | 1999 |
Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors.
Topics: Animals; Benzoates; Bridged Bicyclo Compounds; Cells, Cultured; Cerebral Cortex; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gerbillinae; Glycine; Ischemia; Male; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Thiophenes | 1999 |
Interleukin-8 and leukotriene-B(4), but not formylmethionyl leucylphenylalanine, stimulate CD18-independent migration of neutrophils across human pulmonary endothelial cells in vitro.
Topics: CD11 Antigens; CD18 Antigens; Cell Line; Cell Movement; Chemotactic Factors; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycine; Humans; Hydroxamic Acids; Interleukin-8; L-Selectin; Leukotriene B4; Lung; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Permeability; Phenylalanine; Protease Inhibitors; Pyrazines; Sulfonamides; Thiophenes | 2000 |
Endogenous activation of group-I metabotropic glutamate receptors is required for differentiation and survival of cerebellar Purkinje cells.
Topics: Animals; Animals, Newborn; Benzoates; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; Chromones; Dendrites; Drug Administration Routes; Excitatory Amino Acid Antagonists; Glycine; Immunohistochemistry; Oligonucleotides, Antisense; Purkinje Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiophenes; Time Factors | 2001 |
Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists.
Topics: Alanine; Animals; Benzoates; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Inhibitory Concentration 50; Mice; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Seizures; Structure-Activity Relationship; Thiophenes; Xanthenes | 2002 |
MMP inhibition and the development of cerebrovascular atherosclerosis: The road ahead.
Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Extracellular Matrix; Female; Glycine; Hemodynamics; Humans; Hydroxamic Acids; Infarction, Middle Cerebral Artery; Intracranial Arteriosclerosis; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Phenylalanine; Thiophenes; Treatment Outcome | 2002 |
Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist.
Topics: Animals; Benzoates; Binding, Competitive; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Excitatory Amino Acid Antagonists; Glycine; Indicators and Reagents; Molecular Conformation; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism; Thiophenes | 2004 |
Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand.
Topics: Biological Transport; Calcium; Cell Membrane; Cell Nucleus; Coloring Agents; Cysteine; Cytoplasm; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Glutamic Acid; Glycine; Immunohistochemistry; Ligands; Light; Microscopy, Fluorescence; Models, Biological; Neurons; Phosphorylation; Propionates; Protein Binding; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sodium; Subcellular Fractions; Thiophenes; Time Factors | 2005 |
Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor.
Topics: Animals; Binding, Competitive; Blood-Brain Barrier; Cell Line; Cytoprotection; Electroshock; Glycine; Humans; In Vitro Techniques; Male; Mice; Protein Subunits; Pyridones; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Thiophenes; Transfection | 2006 |
New oral anticoagulants show promise.
Topics: Anticoagulants; Clinical Trials as Topic; Factor Xa Inhibitors; Fondaparinux; Glycine; Humans; Morpholines; Piperazines; Polysaccharides; Rivaroxaban; Thiophenes; Thromboembolism | 2006 |
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Topics: Amino Acid Substitution; Antineoplastic Agents; Arginine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Glutamates; Glycine; Guanine; Humans; Leucovorin; Methotrexate; Mutation; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Purines; Pyrimidines; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 2006 |
Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Calcium; Cell Membrane; Cerebellum; Dimethylamines; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fluorometry; Glycine; Heterocyclic Compounds, 3-Ring; Hindlimb; Male; Molecular Structure; Morphine; Pain, Postoperative; Pyridines; Pyrimidinones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Rotarod Performance Test; Thiophenes; Tritium | 2008 |
alpha,alpha-Cyclopentaneglycine dipeptides capped with biaryls as tachykinin NK(2) receptor antagonists.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Colon; Cyclopentanes; Dipeptides; Glycine; Guinea Pigs; Muscle Contraction; Receptors, Neurokinin-2; Thiophenes | 2008 |
CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.
Topics: Amino Acids; Aminopeptidases; Animals; Biomarkers, Tumor; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Glycine; HL-60 Cells; Humans; Hydroxamic Acids; Immunoblotting; Leucine; Mice; Oligonucleotide Array Sequence Analysis; Peptide Fragments; Phenylalanine; Phosphorylation; Protein Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
PPAR-alpha and PPAR-gamma agonists for type 2 diabetes.
Topics: Alkanesulfonates; Clinical Trials, Phase II as Topic; Diabetes Mellitus, Type 2; Glycine; Humans; Hypoglycemic Agents; Oxazoles; Phenylpropionates; PPAR alpha; PPAR gamma; Thiophenes | 2009 |
Factor Xa inhibitors--new anticoagulants for secondary haemostasis.
Topics: Administration, Oral; Anticoagulants; Factor Xa Inhibitors; Glycine; Hemostasis; Humans; Morpholines; Piperazines; Pyrazoles; Pyridones; Pyrrolidines; Rivaroxaban; Thiophenes; Venous Thromboembolism | 2009 |
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cells, Cultured; Circadian Rhythm; Glycine; Heme; Hepatocytes; Humans; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Subfamily 1, Group D, Member 1; Peptides; Protein Interaction Mapping; Small Molecule Libraries; Thiophenes | 2010 |
Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
Topics: Action Potentials; Animals; Calcium Channels, L-Type; Cerebellar Nuclei; gamma-Aminobutyric Acid; Glycine; Inhibitory Postsynaptic Potentials; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Resorcinols; Synapses; Synaptic Transmission; Thiophenes | 2011 |
Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112.
Topics: Animals; ARNTL Transcription Factors; Circadian Rhythm; Female; Gene Expression Regulation; Glycine; Granulosa Cells; Nuclear Receptor Subfamily 1, Group D, Member 1; Period Circadian Proteins; Phosphoproteins; Promoter Regions, Genetic; Rats; Thiophenes | 2012 |
Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance.
Topics: Amino Acid Chloromethyl Ketones; Animals; Caspase 3; Caspase 7; Caspase Inhibitors; Cell Death; Cell Hypoxia; Cells, Cultured; Glucose; Glycine; Hippocampus; Ischemic Preconditioning; Isoquinolines; MAP Kinase Signaling System; N-Methylaspartate; Neurons; Neuroprotective Agents; Phenanthrenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Resorcinols; Thiophenes | 2012 |
2,3,4,5-Tetrakis(3',4'-dihydroxylphenyl)thiophene: a new matrix for the selective analysis of low molecular weight amines and direct determination of creatinine in urine by MALDI-TOF MS.
Topics: Allantoin; Alloxan; Creatinine; Glycine; Hippurates; Humans; Isotope Labeling; Molecular Weight; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiophenes | 2012 |
Optimized chemical probes for REV-ERBα.
Topics: Amines; Animals; Biological Availability; Carrier Proteins; Cell Line; Circadian Rhythm; Glycine; Humans; Liver X Receptors; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Orphan Nuclear Receptors; Peptide Fragments; Radioligand Assay; RNA-Binding Proteins; Structure-Activity Relationship; Thiophenes | 2013 |
Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Circadian Rhythm; Cytokines; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Glucose; Glycine; Isoquinolines; Metformin; Mice; Nicotinamide Phosphoribosyltransferase; Nuclear Receptor Subfamily 1, Group D, Member 1; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Thiophenes | 2013 |
A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
Topics: Age Factors; Animals; Cell Adhesion; Cell Line; Cell Movement; Chemokine CCL2; Circadian Clocks; Gene Expression; Gene Expression Regulation; Glycine; Inflammation; Integrin beta1; Lipopolysaccharides; Macrophages; Macrophages, Peritoneal; Male; Mice; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; Nuclear Receptor Subfamily 1, Group F, Member 1; Obesity; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Response Elements; Thiophenes; Transcriptional Activation; Vascular Cell Adhesion Molecule-1 | 2014 |
Integration of the nuclear receptor REV-ERBα linked with circadian oscillators in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells.
Topics: 5-Aminolevulinate Synthetase; Animals; Animals, Genetically Modified; Circadian Rhythm; Female; Gene Expression Regulation; Glycine; Granulosa Cells; Heme; Interleukin-6; Isoquinolines; Ligands; Nuclear Receptor Subfamily 1, Group D, Member 1; Ovary; Period Circadian Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; RNA, Small Interfering; Thiophenes; Transcription Factors | 2015 |
Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi.
Topics: Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glycine; Mice; Molecular Docking Simulation; Octoxynol; Protozoan Proteins; Thiazolidines; Thiophenes; Thiourea; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation.
Topics: Animals; Cells, Cultured; Cytokines; Epithelial Cells; Female; Glycine; Humans; Inflammation Mediators; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Nuclear Receptor Subfamily 1, Group D, Member 1; Pneumonia; Smoke; Smoking; Thiophenes | 2017 |
Protein malnutrition after weaning disrupts peripheral clock and daily insulin secretion in mice.
Topics: Adipose Tissue, White; Animals; Biological Clocks; CLOCK Proteins; Diet, Protein-Restricted; Gene Expression Regulation, Developmental; Glycine; Hypothalamus; Insulin; Insulin Secretion; Insulin-Secreting Cells; Isoquinolines; Liver; Male; Mice, Inbred C57BL; Muscle, Skeletal; Neurons; Neuropeptide Y; Nuclear Receptor Subfamily 1, Group D, Member 1; Organ Specificity; Pro-Opiomelanocortin; Protein Deficiency; Random Allocation; Thiophenes; Weaning | 2017 |
Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway.
Topics: Animals; Cell Line, Tumor; Glycine; HEK293 Cells; Humans; Inflammation; Male; Mesencephalon; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Nuclear Receptor Subfamily 1, Group D, Member 1; Pyrrolidines; Signal Transduction; Thiophenes; Transcription Factor RelA | 2019 |
Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice.
Topics: Animals; Astrocytes; Cytokines; Female; Glial Fibrillary Acidic Protein; Glycine; Hyperalgesia; Inflammation; Interleukin-6; Male; Mice; Neuralgia; Nociceptors; Nuclear Receptor Subfamily 1, Group D, Member 1; Primary Cell Culture; Pyrrolidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Spinal Cord; Spinal Cord Dorsal Horn; Thiophenes; Tumor Necrosis Factor-alpha | 2019 |
Rev-erbα can regulate the NF-κB/NALP3 pathway to modulate lipopolysaccharide-induced acute lung injury and inflammation.
Topics: Acute Lung Injury; Animals; Glycine; Interleukin-1beta; Isoquinolines; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Receptor Subfamily 1, Group D, Member 1; RAW 264.7 Cells; Signal Transduction; Thiophenes | 2019 |
Rev-erbα Inhibits Proliferation and Promotes Apoptosis of Preadipocytes through the Agonist GSK4112.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Apoptosis; Cell Proliferation; Glycine; Mice; Nuclear Receptor Subfamily 1, Group D, Member 1; Thiophenes | 2019 |
REV-ERBα Agonist GSK4112 attenuates Fas-induced Acute Hepatic Damage in Mice.
Topics: Acute Disease; Animals; Antibodies; Apoptosis; Chemical and Drug Induced Liver Injury; Circadian Rhythm; fas Receptor; Glycine; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group D, Member 1; Thiophenes | 2021 |