Compounds > thiophenes
Page last updated: 2024-08-18

thiophenes and gamma-aminobutyric acid

thiophenes has been researched along with gamma-aminobutyric acid in 116 studies

Research

Studies (116)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (4.31)18.2507
2000's28 (24.14)29.6817
2010's78 (67.24)24.3611
2020's5 (4.31)2.80

Authors

AuthorsStudies
Berthelot, P; Debaert, M; Flouquet, N; Kerr, DI; Ong, J; Vaccher, C1
Berthelot, P; Brunet, C; Debaert, M; Flouquet, N; Luyckx, M; Vaccher, C1
Timmerman, W1
Dayne Mayfield, R; Larson, G; Orona, RA; Zahniser, NR1
Benham, CD; Harries, MH; Meadows, HJ; Thompson, M1
Hemrick-Luecke, SK; Iyengar, S; Simmons, RM; Webster, AA; Xu, JY1
Foster, AC; Grigoriadis, DE; Gross, RS; Petroski, RE; Sullivan, SK; Verge, G1
Jones, CK; Peters, SC; Shannon, HE1
Berrino, L; de Novellis, V; Maione, S; Marabese, I; Mariani, L; Oliva, P; Palazzo, E; Rossi, F; Scafuro, M; Siniscalco, D1
D'Souza, DN; Iyengar, S; Pritchett, YL; Raskin, J; Smith, TR; Wernicke, JF; Wong, K1
Birnbaum, HG; Gelwicks, S; Le, TK; Mareva, MN; Robinson, RL; Rosen, A; Wu, EQ1
Terneus, W1
Wallace, JM1
Kempler, P; Várkonyi, T1
Baglioni, P; Govindan, J; Khan, A1
Armstrong, DG; Wrobel, JS; Wu, SC1
Robinson-Papp, J; Simpson, DM1
Beard, SM; Garcia-Cebrian, A; Le, TK; Malik, RA; McCrink, L; Monz, B1
Hutson, PH; McDonald, LM; Sheppard, WF; Sohal, B; Staveley, SM; Tattersall, FD1
Price, DD; Staud, R1
Han, C; Marks, DC; Masand, PS; Pae, CU; Patkar, AA1
Forde, G; Stanos, S1
Derry, S; McQuay, HJ; Moore, RA1
Eisenach, JC; Hayashida, K1
Genth, E; Harten, P1
Holloway, RG; Noyes, K; O'Connor, AB1
Mabrouk, OS; Marti, M; Morari, M; Volta, M1
Sipkoff, M1
Chancellor, J; Garcia-Cebrian, A; Le, TK; Löthgren, M; Monz, B; Quilici, S; Said, G; Simon, D1
Alda, M; Andrés, E; del Hoyo, YL; García-Campayo, J; Luciano, JV; Magallón, R; Rodero, B; Serrano-Blanco, A1
Apostolaki, S; Arvaniti, C; Chatzimichael, K; Kitsiou, MC; Kostopanagiotou, G; Matsota, P1
Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT1
Rao, SG1
Aliaga, M; Bardin, L; Depoortère, R; Gregoire, S; Ladure, P; Malfetes, N; Newman-Tancredi, A; Vitton, O1
Staud, R1
Briley, M1
Kempler, P1
Esfahani, F; Gomori, A; Grossberndt, A; Intrater, H; Klowak, M; Leong, C; Namaka, M; Turcotte, D1
Bowrin, K; Choy, E; Lloyd, A; Richards, S; Sadosky, A; Watson, P; Zlateva, G1
Häuser, W; Petzke, F; Sommer, C1
Dyhr, H; Grunnet, M; Munro, G1
Ferrari, G; Gemignani, F; Giovanelli, M; Macaluso, C; Marbini, A; Vitetta, F1
Hettinger, K; Lindsay, TJ; Rodgers, BC; Savath, V1
Cao, Z; Fowler, R; Harnett, J; Mardekian, J; Margolis, J; Sanchez, RJ; Silverman, SL1
Budhia, S; Gabriel, Z; Plested, M1
Sun, P; Watson, P; Zhao, Y1
Armstrong, EP; Malone, DC; McCarberg, B; Panarites, CJ; Pham, SV1
Burke, JP; Cappelleri, JC; Halpern, R; Joshi, AV; Kulakodlu, M; Sanchez, RJ2
Barohn, RJ; Dimachkie, MM; Herbelin, L; Khan, S; McVey, A; Mittal, M; Mummaneni, RB; Pasnoor, M; Ridings, L; Saperstein, D; Wang, Y1
Fleming, KF; Wu, JJ1
Thiessen, CN; Traynor, AP; Traynor, LM1
Ahl, J; Irving, GA; Malcolm, SK; Risser, RC; Robinson, MJ; Skljarevski, V; Tanenberg, RJ1
Raman, IM; Zheng, N1
Sun, P; Watson, P; Zhao, Y; Zhao, Z1
Arora, V; Chopra, K; Kuhad, A1
Emel'ianov, VV; Galkin, VV; Nesterova, MV1
Chandran, A; Gore, M; Leslie, D; Tai, KS; Zlateva, G1
Kruger, TH; Philippsohn, S1
Carlos, F; Dueñas, H; Galindo-Suárez, RM; Ramírez-Gámez, J; Ramos, E1
Rizzi, M; Sarzi-Puttini, P; Spaeth, M1
Dundon, K; Mease, PJ; Sarzi-Puttini, P1
Ebenezer, GJ; Hauer, P; McArthur, JC; Polydefkis, MJ; Tan, IL1
Bernauer, M; Sun, P; Watson, P; Zhao, Y; Zhao, Z1
Bannon, AW; Decker, MW; Gauvin, D; Hsieh, GC; Joshi, SK; Lee, CH; Lewis, LG; Mikusa, J; Mills, CD; Rueter, LE; Zhong, C; Zhu, CZ1
Dyhr, H; Erichsen, HK; Hansen, MK; Marcher, L; Munro, G; Sheykhzade, M; Storm, A1
Miyazaki, R; Yamamoto, T1
Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y1
Bellows, BK; Biskupiak, J; Dahal, A; Jiao, T1
Fujisaka, Y; Kaneda, H; Koyama, A; Makimura, C; Matsuoka, H; Nakagawa, K; Okamoto, W; Otsuka, M; Tsurutani, J1
Ardid, D; Chapuy, E; Eschalier, A; Grégoire, S; Michaud, V1
Alten, R; Bär, KJ; Häuser, W; Petzke, F; Sommer, C; Späth, M; Tölle, T; Uçeyler, N; Winkelmann, A; Winter, E1
de Biase, S; Gigli, GL; Lorenzut, S; Merlino, G; Valente, M1
Bannon, AW; Gauvin, DM; Gomez, EJ; Mikusa, J; Mills, CD; Nguyen, T; Salyers, AK; Tanga, FY; Zhong, C1
Boyle, J; Coppini, DV; Eriksson, ME; Gouni, R; Gribble, L; Johnsen, S; Kerr, D1
Angeletti, C; Angeletti, PM; Ciccozzi, A; Guetti, C; Marinangeli, F; Paladini, A; Piroli, A; Varrassi, G1
Bansal, M; Happich, M; Klein, R; Wielage, R; Wilson, K1
Crowell, K; Deluca, J; Page, N1
Darwin, KC; Hallett, M; Jinnah, HA; Mari, Z; Rosenthal, LS1
Andrews, JS; Faries, DE; Novick, D; Peng, X; Sun, P; Sun, S; Wohlreich, MM; Wu, A1
Amital, D; Amital, H; Arnson, Y; Milstein, R1
Silvestri, NJ; Trivedi, JR; Wolfe, GI1
Bouhassira, D; Cruccu, G; Freynhagen, R; Lledo, A; Schacht, A; Skljarevski, V; Tesfaye, S; Tölle, T; Wilhelm, S1
Finnerup, NB1
Kim, SC; Landon, JE; Solomon, DH1
Boulton, AJ; Dickenson, AH; Tesfaye, S1
Gupta, R; Koo, JY; Levin, E; Liao, W; Wu, JJ1
Cappelleri, JC; Chu, BC; Johnson, BH; Johnston, SS; Shrady, G; Silverman, SL; Udall, M2
Birklein, F; Boess, FG; Happich, M; Schacht, A; Schneider, E; Wilhelm, S; Ziegler, D1
Scheinfeld, N1
Aldington, DJ; Kalso, E; Moore, RA1
Aguado, J; Alda, M; Garcia-Campayo, J; Gili, M; Guallar, JA; López-Del-Hoyo, Y; Luciano, JV; Magallón, R; Olivan, B; Serrano-Blanco, A1
Benoliel, R; Haviv, Y; Sharav, Y; Zadik, Y1
Caballero, A; Cass, DK; Flores-Barrera, E; Thomases, DR; Tseng, KY; Vital, WF1
Castagné, V; Le Cudennec, C1
Bak, K; Bleeker, J; Cavaletti, G; Chauhan, C; Dworkin, RH; Gavin, P; Hershman, DL; Lacchetti, C; Lavino, A; Lavoie Smith, EM; Loprinzi, CL; Lustberg, MB; Paice, J; Schneider, B; Smith, ML; Smith, T; Terstriep, S; Wagner-Johnston, N1
Callaghan, BC; Goutman, SA; Peltier, A1
Bhuvaneswaran, C; Felix, AR; Flood, DG; Hilt, D; Huang, M; Koenig, G; Meltzer, HY1
Toro, BE1
Morel, T; Sun, Y; van Valkenhoef, G1
Bencherif, M; Budygin, E; Grinevich, V; Grinevich, VP; Gutkin, B; Maex, R1
Cerdà-Lafont, M; Cuesta-Vargas, AI; D'Amico, F; García-Campayo, J; Knapp, M; Luciano, JV; Peñarrubia-María, MT; Serrano-Blanco, A1
Doud, E; Hawker, DD; Kelleher, NL; Le, HV; Liu, D; Sanishvili, R; Silverman, RB; Widom, J; Wu, R1
Jankovic, J; Wijemanne, S1
Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R1
Kiss, G1
Jo, J; Mousa, SA; Sahli, ZT; Tarazi, FI1
Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E1
Alghothani, L; Iftikhar, IH; Trotti, LM1
Agarwal, H; Ellis-Davies, GCR; Passlick, S; Richers, MT1
Chen, M; Chen, X; Guo, L; Wang, F; Wu, B; Xu, H; Xu, Y; Yu, F; Yu, J; Zhang, T; Zhou, C1
Dai, W; Piao, C; Wang, X; Yu, H; Yue, Y; Zhang, L1
Akiz, C; Aoki, C; Du, M; Santiago, A1
Anaclet, C; Ferrari, LL; Gompf, HS; Ogbeide-Latario, OE1
Billard, JM; Bouet, V; Freret, T; Lahogue, C1

Reviews

31 review(s) available for thiophenes and gamma-aminobutyric acid

ArticleYear
Update on pharmacotherapy guidelines for treatment of neuropathic pain.
    Current pain and headache reports, 2007, Volume: 11, Issue:3

    Topics: Analgesics; Animals; Cannabidiol; Chronic Disease; Dronabinol; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Guidelines as Topic; Humans; Pain; Peripheral Nervous System Diseases; Pregabalin; Thiophenes

2007
Diabetic neuropathy: new strategies for treatment.
    Diabetes, obesity & metabolism, 2008, Volume: 10, Issue:2

    Topics: Aldehyde Reductase; Amines; Analgesics; Anticonvulsants; Antidepressive Agents; Antioxidants; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Pregabalin; Thiamine; Thioctic Acid; Thiophenes

2008
Assessing the impact of pharmacologic intervention on the quality of life in diabetic peripheral neuropathic pain and fibromyalgia.
    Pain medicine (Malden, Mass.), 2007, Volume: 8 Suppl 2

    Topics: Antidepressive Agents; Diabetic Neuropathies; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Pain; Pregabalin; Quality of Life; Randomized Controlled Trials as Topic; Thiophenes

2007
Safety profile of treatment in diabetic peripheral neuropathic pain.
    Pain medicine (Malden, Mass.), 2007, Volume: 8 Suppl 2

    Topics: Administration, Topical; Analgesics; Anesthetics, Local; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Capsaicin; Cyclohexanols; Diabetic Neuropathies; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Pain; Pregabalin; Thiophenes; Venlafaxine Hydrochloride

2007
Practical management strategies for the chronic pain patient.
    The Journal of family practice, 2007, Volume: 56, Issue:8 Suppl Ho

    Topics: Administration, Cutaneous; Amines; Analgesics; Antidepressive Agents, Tricyclic; Carbamazepine; Chronic Disease; Clinical Protocols; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Monitoring; Drug Tolerance; Duloxetine Hydrochloride; Family Practice; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lidocaine; Middle Aged; Pain; Practice Guidelines as Topic; Pregabalin; Randomized Controlled Trials as Topic; Substance-Related Disorders; Thiophenes; Treatment Outcome

2007
Meta-analysis of duloxetine vs. pregabalin and gabapentin in the treatment of diabetic peripheral neuropathic pain.
    BMC neurology, 2009, Feb-10, Volume: 9

    Topics: Amines; Analgesics; Analysis of Variance; Bayes Theorem; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain; Pain Measurement; Peripheral Nervous System; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes; Treatment Outcome

2009
Current progress in the pharmacological therapy of fibromyalgia.
    Expert opinion on investigational drugs, 2009, Volume: 18, Issue:10

    Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Clinical Trials as Topic; Cyclopropanes; Drugs, Investigational; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Milnacipran; Pregabalin; Selective Serotonin Reuptake Inhibitors; Thiophenes

2009
A treatment algorithm for neuropathic pain: an update.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2009, Volume: 24, Issue:12

    Topics: Algorithms; Analgesics; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Neuralgia; Pain Measurement; Paroxetine; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes

2009
Comparative efficacy and harms of duloxetine, milnacipran, and pregabalin in fibromyalgia syndrome.
    The journal of pain, 2010, Volume: 11, Issue:6

    Topics: Analgesics; Cyclopropanes; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Milnacipran; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes; Treatment Outcome

2010
Treating diabetic peripheral neuropathic pain.
    American family physician, 2010, Jul-15, Volume: 82, Issue:2

    Topics: Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Complementary Therapies; Diabetic Neuropathies; Drug Interactions; Drug Therapy, Combination; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Pain; Pain Measurement; Pregabalin; Recovery of Function; Thiophenes

2010
Pregabalin, the lidocaine plaster and duloxetine in patients with refractory neuropathic pain: a systematic review.
    BMC neurology, 2010, Nov-19, Volume: 10

    Topics: Analgesics; Anesthetics, Local; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Lidocaine; Neuralgia; Pregabalin; Thiophenes; Treatment Outcome

2010
Cost-effectiveness analysis of a new 8% capsaicin patch compared to existing therapies for postherpetic neuralgia.
    Current medical research and opinion, 2011, Volume: 27, Issue:5

    Topics: Administration, Topical; Amines; Anesthetics, Local; Antidepressive Agents, Tricyclic; Capsaicin; Clinical Trials as Topic; Costs and Cost Analysis; Cyclohexanecarboxylic Acids; Dopamine Uptake Inhibitors; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Lidocaine; Male; Markov Chains; Neuralgia, Postherpetic; Pregabalin; Quality of Life; Sensory System Agents; Thiophenes; Transdermal Patch

2011
Pharmacotherapy of fibromyalgia.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2011, Jul-15, Volume: 68, Issue:14

    Topics: Analgesics; Animals; Antidepressive Agents; Clinical Trials as Topic; Cyclopropanes; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Milnacipran; Pregabalin; Thiophenes

2011
Neoteric pharmacotherapeutic targets in fibromyalgia.
    Expert opinion on therapeutic targets, 2011, Volume: 15, Issue:11

    Topics: Animals; Cyclopropanes; Drug Approval; Drug Delivery Systems; Drug Design; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Milnacipran; Pregabalin; Thiophenes; United States; United States Food and Drug Administration

2011
Fibromyalgia and sleep.
    Best practice & research. Clinical rheumatology, 2011, Volume: 25, Issue:2

    Topics: Analgesics; Central Nervous System Sensitization; Chronic Pain; Cyclopropanes; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Milnacipran; Physical Therapy Modalities; Polysomnography; Pregabalin; Selective Serotonin Reuptake Inhibitors; Sleep; Sleep Wake Disorders; Syndrome; Thiophenes

2011
Pharmacotherapy of fibromyalgia.
    Best practice & research. Clinical rheumatology, 2011, Volume: 25, Issue:2

    Topics: Analgesics; Chronic Pain; Clinical Trials as Topic; Cognition Disorders; Cyclopropanes; Duloxetine Hydrochloride; Fatigue; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Milnacipran; Mood Disorders; Pain Management; Pregabalin; Selective Serotonin Reuptake Inhibitors; Sleep Wake Disorders; Syndrome; Thiophenes; Treatment Outcome

2011
[Drug therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline].
    Schmerz (Berlin, Germany), 2012, Volume: 26, Issue:3

    Topics: Amitriptyline; Analgesics; Analgesics, Opioid; Antidepressive Agents; Anxiety Disorders; Combined Modality Therapy; Comorbidity; Cooperative Behavior; Depressive Disorder, Major; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Germany; Humans; Interdisciplinary Communication; Off-Label Use; Patient Care Team; Pregabalin; Somatoform Disorders; Thiophenes

2012
ADMET considerations for restless leg syndrome drug treatments.
    Expert opinion on drug metabolism & toxicology, 2012, Volume: 8, Issue:10

    Topics: Amines; Anticonvulsants; Benzothiazoles; Carbamates; Cyclohexanecarboxylic Acids; Dopamine Agents; Dopamine Agonists; Ergolines; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Levodopa; Neuralgia; Pramipexole; Pregabalin; Randomized Controlled Trials as Topic; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome

2012
Cost-effectiveness of duloxetine in chronic low back pain: a Quebec societal perspective.
    Spine, 2013, May-15, Volume: 38, Issue:11

    Topics: Age Factors; Aged; Amitriptyline; Analgesics; Cardiovascular Diseases; Celecoxib; Chronic Disease; Clinical Trials as Topic; Cost-Benefit Analysis; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Gastrointestinal Diseases; Humans; Hydromorphone; Low Back Pain; Markov Chains; Middle Aged; Models, Economic; Naproxen; Ontario; Osteoarthritis; Outcome Assessment, Health Care; Oxycodone; Pregabalin; Pyrazoles; Quality-Adjusted Life Years; Quebec; Sulfonamides; Thiophenes

2013
Clinical inquiry: what medications are best for diabetic neuropathic pain?
    The Journal of family practice, 2012, Volume: 61, Issue:11

    Topics: Amines; Analgesics; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Practice Guidelines as Topic; Thiophenes

2012
Clinical Reasoning: a 57-year-old man with jaw spasms.
    Neurology, 2013, Mar-05, Volume: 80, Issue:10

    Topics: Adrenergic Uptake Inhibitors; Amines; Anticonvulsants; Brain Neoplasms; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Facial Muscles; Gabapentin; gamma-Aminobutyric Acid; Hemangioma; Humans; Jaw; Male; Middle Aged; Spasm; Thiophenes

2013
Treatment of painful peripheral neuropathy.
    Neurologic clinics, 2013, Volume: 31, Issue:2

    Topics: Analgesics; Antidepressive Agents; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Neuralgia; Pain Management; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes

2013
Mechanisms and management of diabetic painful distal symmetrical polyneuropathy.
    Diabetes care, 2013, Volume: 36, Issue:9

    Topics: Diabetic Neuropathies; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Pain; Peripheral Nervous System Diseases; Pregabalin; Thiophenes

2013
Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine.
    Dermatology online journal, 2013, Nov-15, Volume: 19, Issue:11

    Topics: Acetaminophen; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclohexanecarboxylic Acids; Cyclohexanols; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hidradenitis Suppurativa; Humans; Pain; Pain Management; Pregabalin; Pyrazoles; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Thiophenes; Venlafaxine Hydrochloride

2013
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Jun-20, Volume: 32, Issue:18

    Topics: Adult; Amines; Amitriptyline; Analgesics; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineoplastic Agents; Baclofen; Comorbidity; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Duloxetine Hydrochloride; Evidence-Based Medicine; Gabapentin; gamma-Aminobutyric Acid; Gels; Humans; Incidence; Ketamine; Neoplasms; Neuralgia; Peripheral Nervous System Diseases; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Survivors; Thiophenes; Treatment Outcome; United States

2014
Painful diabetic neuropathy.
    BMJ (Clinical research ed.), 2014, May-06, Volume: 348

    Topics: Amines; Analgesics; Analgesics, Opioid; Biopsy; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Hypoglycemic Agents; Pregabalin; Sensory Thresholds; Skin; Thiophenes; Touch Perception

2014
New treatment options for the management of restless leg syndrome.
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 2014, Volume: 46, Issue:4

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Carbamates; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; gamma-Aminobutyric Acid; Guideline Adherence; Humans; Middle Aged; Nursing Diagnosis; Pregnancy; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Young Adult

2014
Restless legs syndrome: clinical presentation diagnosis and treatment.
    Sleep medicine, 2015, Volume: 16, Issue:6

    Topics: Amines; Analgesics, Opioid; Benzothiazoles; Cyclohexanecarboxylic Acids; Dopamine Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Methadone; Pramipexole; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes

2015
[DRUG THERAPY OF NEUROPATHIC PAIN BASED ON THE LATEST RECOMMENDATIONS].
    Ideggyogyaszati szemle, 2015, Mar-30, Volume: 68, Issue:3-4

    Topics: Amines; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Neuralgia; Practice Guidelines as Topic; Pregabalin; Thiophenes

2015
Clinical management of restless legs syndrome in end-stage renal disease patients.
    CNS spectrums, 2017, Volume: 22, Issue:1

    Topics: Amines; Analgesics, Opioid; Benzodiazepines; Benzothiazoles; Comorbidity; Cyclohexanecarboxylic Acids; Dopamine Agonists; Excitatory Amino Acid Antagonists; Exercise Therapy; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Intermittent Pneumatic Compression Devices; Kidney Failure, Chronic; Levodopa; Massage; Pramipexole; Quality of Life; Renal Dialysis; Restless Legs Syndrome; Sleep Hygiene; Tetrahydronaphthalenes; Thiophenes

2017
Gabapentin enacarbil, pregabalin and rotigotine are equally effective in restless legs syndrome: a comparative meta-analysis.
    European journal of neurology, 2017, Volume: 24, Issue:12

    Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dopamine Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Pregabalin; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome

2017

Trials

10 trial(s) available for thiophenes and gamma-aminobutyric acid

ArticleYear
Duloxetine versus routine care in the long-term management of diabetic peripheral neuropathic pain.
    Journal of palliative medicine, 2006, Volume: 9, Issue:1

    Topics: Amines; Amitriptyline; Analysis of Variance; Cyclohexanecarboxylic Acids; Cyclohexanols; Diabetic Neuropathies; Double-Blind Method; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome; Venlafaxine Hydrochloride

2006
Cost-effectiveness of duloxetine versus routine treatment for U.S. patients with diabetic peripheral neuropathic pain.
    The journal of pain, 2006, Volume: 7, Issue:6

    Topics: Adrenergic Uptake Inhibitors; Aged; Amines; Amitriptyline; Analgesia; Analgesics; Brain; Cohort Studies; Cost-Benefit Analysis; Cyclohexanecarboxylic Acids; Cyclohexanols; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Norepinephrine; Pain Measurement; Pain Threshold; Placebo Effect; Serotonin; Thiophenes; Treatment Outcome; United States; Venlafaxine Hydrochloride

2006
Effectiveness of the psychological and pharmacological treatment of catastrophization in patients with fibromyalgia: a randomized controlled trial.
    Trials, 2009, Apr-23, Volume: 10

    Topics: Adolescent; Adult; Aged; Analgesics; Antidepressive Agents; Cognitive Behavioral Therapy; Combined Modality Therapy; Depression; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Middle Aged; Pain; Pain Management; Pain Measurement; Pregabalin; Psychiatric Status Rating Scales; Research Design; Spain; Thiophenes; Time Factors; Treatment Outcome; Young Adult

2009
Duloxetine, pregabalin, and duloxetine plus gabapentin for diabetic peripheral neuropathic pain management in patients with inadequate pain response to gabapentin: an open-label, randomized, noninferiority comparison.
    Mayo Clinic proceedings, 2011, Volume: 86, Issue:7

    Topics: Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia; Pain Measurement; Pregabalin; Thiophenes; Treatment Outcome

2011
[Biological age and the pain syndrome at diabetic polyneuropathy].
    Advances in gerontology = Uspekhi gerontologii, 2011, Volume: 24, Issue:2

    Topics: Adult; Aging; Amines; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain; Selective Serotonin Reuptake Inhibitors; Syndrome; Thiophenes; Treatment Outcome

2011
Pilot study of duloxetine for cancer patients with neuropathic pain non-responsive to pregabalin.
    Anticancer research, 2012, Volume: 32, Issue:5

    Topics: Adult; Aged; Analgesics; Antidepressive Agents; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neoplasms; Neuralgia; Pilot Projects; Pregabalin; Thiophenes

2012
Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life.
    Diabetes care, 2012, Volume: 35, Issue:12

    Topics: Aged; Amitriptyline; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain; Pregabalin; Quality of Life; Sleep; Thiophenes; Treatment Outcome

2012
Duloxetine and pregabalin: high-dose monotherapy or their combination? The "COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain.
    Pain, 2013, Volume: 154, Issue:12

    Topics: Aged; Analgesics; Diabetic Neuropathies; Double-Blind Method; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Internationality; Male; Middle Aged; Pain; Pregabalin; Thiophenes; Treatment Outcome

2013
Effectiveness of group acceptance and commitment therapy for fibromyalgia: a 6-month randomized controlled trial (EFFIGACT study).
    Pain, 2014, Volume: 155, Issue:4

    Topics: Acceptance and Commitment Therapy; Adolescent; Adult; Aged; Analgesics; Catastrophization; Duloxetine Hydrochloride; Female; Fibromyalgia; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain Measurement; Patient Compliance; Pregabalin; Psychiatric Status Rating Scales; Surveys and Questionnaires; Thiophenes; Treatment Outcome; Young Adult

2014
Cost-utility of cognitive behavioral therapy versus U.S. Food and Drug Administration recommended drugs and usual care in the treatment of patients with fibromyalgia: an economic evaluation alongside a 6-month randomized controlled trial.
    Arthritis research & therapy, 2014, Oct-01, Volume: 16, Issue:5

    Topics: Adult; Analgesics; Cognitive Behavioral Therapy; Cost-Benefit Analysis; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Health Care Costs; Humans; Male; Middle Aged; Pregabalin; Quality of Life; Quality-Adjusted Life Years; Surveys and Questionnaires; Thiophenes; Time Factors; Treatment Outcome; United States; United States Food and Drug Administration

2014

Other Studies

75 other study(ies) available for thiophenes and gamma-aminobutyric acid

ArticleYear
Differing actions of beta-(2-thienyl)-gamma-aminobutyric acid in central and peripheral preparations.
    European journal of pharmacology, 1992, Oct-06, Volume: 221, Issue:1

    Topics: Animals; Baclofen; Brain; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Receptors, GABA-A; Structure-Activity Relationship; Thiophenes

1992
3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Animals; Baclofen; Binding, Competitive; Brain; Chemical Phenomena; Chemistry; Furans; gamma-Aminobutyric Acid; Molecular Structure; Muscimol; Rats; Receptors, GABA-A; Synaptic Membranes; Thiophenes

1991
Dopaminergic receptor agents and the basal ganglia: pharmacological properties and interactions with the GABA-ergic system.
    Pharmacy world & science : PWS, 1993, Apr-23, Volume: 15, Issue:2

    Topics: Animals; Basal Ganglia; Behavior, Animal; Dopamine Agents; gamma-Aminobutyric Acid; Humans; Parkinson Disease; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Tetrahydronaphthalenes; Thiophenes

1993
Opposing actions of adenosine A2a and dopamine D2 receptor activation on GABA release in the basal ganglia: evidence for an A2a/D2 receptor interaction in globus pallidus.
    Synapse (New York, N.Y.), 1996, Volume: 22, Issue:2

    Topics: Adenosine; Animals; Antihypertensive Agents; Basal Ganglia; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Phenethylamines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Purinergic P1; Tetrahydronaphthalenes; Thiophenes

1996
Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum.
    British journal of pharmacology, 1997, Volume: 121, Issue:7

    Topics: Aminopyridines; Animals; Cells, Cultured; Cerebellum; Chloride Channels; GABA Modulators; gamma-Aminobutyric Acid; Rats; Receptors, GABA-A; Thiophenes

1997
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:2

    Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cyclohexanols; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Methyltyrosines; Milnacipran; Neuromuscular Junction; Norepinephrine; p-Chloroamphetamine; Pain; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Thiophenes; Venlafaxine Hydrochloride

2004
Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:2

    Topics: Acetamides; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Kinetics; Male; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiophenes; Triazolam; Tritium; Zolpidem

2004
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Carrageenan; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ibuprofen; Inflammation; Male; Mice; Morphine; Norepinephrine; Pain; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Serotonin Reuptake Inhibitors; Thiophenes

2005
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: Acetates; Acrylamides; Animals; Benzyl Compounds; Dimethyl Sulfoxide; Extracellular Fluid; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Male; Mice; Microdialysis; Misoprostol; Naphthalenes; Pain Measurement; Periaqueductal Gray; Prostaglandin Antagonists; Receptors, Prostaglandin E; Thiophenes; Triazoles; Xanthones

2006
Pregabalin and duloxetine for the treatment of neuropathic pain disorders.
    Journal of pain & palliative care pharmacotherapy, 2007, Volume: 21, Issue:1

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Neuralgia; Pain; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes

2007
Career lifetime advances and key developments: diabetes.
    Clinical medicine (London, England), 2007, Volume: 7, Issue:3

    Topics: Amines; Amitriptyline; Analgesics; Antidepressive Agents; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Pregabalin; Thiophenes

2007
Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK.
    Current medical research and opinion, 2008, Volume: 24, Issue:2

    Topics: Amines; Amitriptyline; Antidepressive Agents; Cost-Benefit Analysis; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Models, Econometric; Paclitaxel; Pain Measurement; Prospective Studies; Quality-Adjusted Life Years; Sickness Impact Profile; Thiophenes; Treatment Outcome; United Kingdom

2008
Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.
    Psychopharmacology, 2008, Volume: 197, Issue:4

    Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Azabicyclo Compounds; Baclofen; Benzodiazepines; Bicuculline; Brain; Cyclohexanecarboxylic Acids; Discrimination Learning; Dose-Response Relationship, Drug; GABA Agents; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Generalization, Stimulus; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoxazoles; Male; Nipecotic Acids; Piperazines; Pyridines; Rats; Thiophenes; Tiagabine; Zolpidem

2008
Long-term trials of pregabalin and duloxetine for fibromyalgia symptoms: how study designs can affect placebo factors.
    Pain, 2008, Volume: 136, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Analgesics; Clinical Protocols; Clinical Trials as Topic; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Longitudinal Studies; Outcome Assessment, Health Care; Placebo Effect; Pregabalin; Thiophenes; Treatment Outcome

2008
Duloxetine: an emerging evidence for fibromyalgia.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2009, Volume: 63, Issue:1

    Topics: Analgesics; Antidepressive Agents; Cyclopropanes; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Milnacipran; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes

2009
Response to: Long-term trials of pregabalin and duloxetine for fibromyalgia symptoms: How study designs can affect placebo factors.
    Pain, 2008, Oct-15, Volume: 139, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Analgesics; Clinical Protocols; Clinical Trials as Topic; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Longitudinal Studies; Outcome Assessment, Health Care; Placebo Effect; Pregabalin; Thiophenes; Treatment Outcome

2008
Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
    European journal of pharmacology, 2008, Nov-19, Volume: 598, Issue:1-3

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Indans; Injections, Spinal; Ligation; Male; Neurotransmitter Uptake Inhibitors; Nootropic Agents; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Postural Balance; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Nerves; Thiophenes

2008
[Evidence-based recommendations for the treatment of fibromyalgia syndrome].
    Zeitschrift fur Rheumatologie, 2010, Volume: 69, Issue:5

    Topics: Adrenergic Uptake Inhibitors; Analgesics; Antidepressive Agents; Combined Modality Therapy; Consensus Development Conferences as Topic; Cross-Sectional Studies; Duloxetine Hydrochloride; Evidence-Based Medicine; Exercise Therapy; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Practice Guidelines as Topic; Pregabalin; Selective Serotonin Reuptake Inhibitors; Thiophenes

2010
A cost-utility comparison of four first-line medications in painful diabetic neuropathy.
    PharmacoEconomics, 2008, Volume: 26, Issue:12

    Topics: Amines; Analgesics; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Cross-Sectional Studies; Cyclohexanecarboxylic Acids; Desipramine; Diabetic Neuropathies; Duloxetine Hydrochloride; Economics, Pharmaceutical; Gabapentin; gamma-Aminobutyric Acid; Humans; Middle Aged; Pregabalin; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Thiophenes

2008
Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.
    Journal of neurochemistry, 2008, Volume: 107, Issue:6

    Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hindlimb Suspension; Male; Microdialysis; Motor Activity; Oxidopamine; Parkinsonian Disorders; Piperazines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Substantia Nigra; Thiophenes; Time Factors

2008
Fibromyalgia coverage uneven despite recent drug approvals.
    Managed care (Langhorne, Pa.), 2008, Volume: 17, Issue:12

    Topics: Analgesics; Duloxetine Hydrochloride; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Insurance, Pharmaceutical Services; Pregabalin; Selective Serotonin Reuptake Inhibitors; Sickness Impact Profile; Thiophenes; United States; United States Food and Drug Administration

2008
Successful pain relief of cutaneous leiomyomata due to reed syndrome with the combination treatment of pregabalin and duloxetine.
    Journal of pain and symptom management, 2009, Volume: 38, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Leiomyoma; Pain; Pregabalin; Selective Serotonin Reuptake Inhibitors; Skin Neoplasms; Thiophenes

2009
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
    Brain research, 2009, Oct-27, Volume: 1295

    Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Edema; Freund's Adjuvant; Gabapentin; Gait; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Male; Morphine; Neuralgia; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Thiophenes

2009
Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats.
    Neuroscience research, 2010, Volume: 66, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Analgesics; Analysis of Variance; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Electroshock; Formaldehyde; gamma-Aminobutyric Acid; Male; Milnacipran; Pain; Pain Measurement; Pregabalin; Rats; Rats, Sprague-Dawley; Stress, Physiological; Thiophenes; Vocalization, Animal

2010
Pharmacological treatment of fibromyalgia syndrome: new developments.
    Drugs, 2010, Volume: 70, Issue:1

    Topics: Age Factors; Analgesics, Opioid; Calcium Channel Blockers; Clinical Trials as Topic; Cognitive Behavioral Therapy; Combined Modality Therapy; Dopamine Agonists; Duloxetine Hydrochloride; Exercise; Exercise Therapy; Fatigue; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Pain; Pain Measurement; Pain Threshold; Pregabalin; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Research Design; Self Care; Thiophenes; Treatment Outcome

2010
Drugs to treat fibromyalgia - the transatlantic difference.
    Current opinion in investigational drugs (London, England : 2000), 2010, Volume: 11, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Analgesics; Cyclopropanes; Drug Approval; Duloxetine Hydrochloride; European Union; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Milnacipran; Off-Label Use; Pregabalin; Thiophenes; United States; United States Food and Drug Administration

2010
[Treatment of neuropathies].
    Orvosi hetilap, 2010, Jan-10, Volume: 151, Issue:2

    Topics: Adjuvants, Immunologic; Adrenergic Uptake Inhibitors; Amines; Analgesics; Antioxidants; Capsaicin; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Polyneuropathies; Pregabalin; Sensory System Agents; Thiamine; Thioctic Acid; Thiophenes

2010
Cost effectiveness of pregabalin in the treatment of fibromyalgia from a UK perspective.
    Current medical research and opinion, 2010, Volume: 26, Issue:4

    Topics: Adult; Amines; Amitriptyline; Analgesics; Antidepressive Agents; Cost-Benefit Analysis; Cyclohexanecarboxylic Acids; Drug Costs; Duloxetine Hydrochloride; Fibromyalgia; Gabapentin; gamma-Aminobutyric Acid; Humans; Markov Chains; Models, Econometric; Pregabalin; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Thiophenes; Tramadol; United Kingdom

2010
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.
    Neuropharmacology, 2010, Volume: 59, Issue:3

    Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Duloxetine Hydrochloride; Exploratory Behavior; Gabapentin; gamma-Aminobutyric Acid; Male; Mecamylamine; Morphine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pyridines; Rats; Rats, Sprague-Dawley; Thiophenes

2010
Non-length-dependent small fibre neuropathy. Confocal microscopy study of the corneal innervation.
    Journal of neurology, neurosurgery, and psychiatry, 2010, Volume: 81, Issue:7

    Topics: Adult; Amines; Amitriptyline; Analgesics; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Biopsy; Cornea; Crohn Disease; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Electrophysiology; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Microscopy, Confocal; Middle Aged; Nerve Endings; Nerve Fibers; Peripheral Nervous System Diseases; Sensation Disorders; Sjogren's Syndrome; Skin; Thiophenes; Trigeminal Nerve

2010
Evaluation of healthcare resource utilization and costs in employees with pain associated with diabetic peripheral neuropathy treated with pregabalin or duloxetine.
    Journal of medical economics, 2010, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Age Factors; Analgesics; Comorbidity; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Health Services; Humans; Insurance Claim Review; Male; Middle Aged; Pain; Pregabalin; Sex Factors; Socioeconomic Factors; Thiophenes; Young Adult

2010
Medication adherence and healthcare costs among patients with diabetic peripheral neuropathic pain initiating duloxetine versus pregabalin.
    Current medical research and opinion, 2011, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Analgesics; Cohort Studies; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Health Care Costs; Humans; Male; Medication Adherence; Middle Aged; Neuralgia; Pregabalin; Retrospective Studies; Thiophenes; Young Adult

2011
Health care costs in patients with fibromyalgia on pregabalin vs. duloxetine.
    Pain practice : the official journal of World Institute of Pain, 2012, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Aged; Analgesics; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Health Care Costs; Humans; Insurance Claim Review; Male; Middle Aged; Pregabalin; Thiophenes; Young Adult

2012
Retrospective chart review of duloxetine and pregabalin in the treatment of painful neuropathy.
    The International journal of neuroscience, 2011, Volume: 121, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Analgesics; Dopamine Uptake Inhibitors; Duloxetine Hydrochloride; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuralgia; Pregabalin; Retrospective Studies; Thiophenes; Treatment Outcome

2011
Health care costs in patients with painful diabetic peripheral neuropathy prescribed pregabalin or duloxetine.
    Pain practice : the official journal of World Institute of Pain, 2012, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Analgesics; Cohort Studies; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Health Care Costs; Health Services; Humans; Male; Managed Care Programs; Middle Aged; Pregabalin; Thiophenes; United States

2012
Interaction between adalimumab with concurrent pregabalin and duloxetine administration in a psoriasis patient with diabetic peripheral neuropathy.
    Cutis, 2011, Volume: 87, Issue:5

    Topics: Adalimumab; Analgesics; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Drug Interactions; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Pregabalin; Psoriasis; Selective Serotonin Reuptake Inhibitors; Thiophenes; Young Adult

2011
Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jul-13, Volume: 31, Issue:28

    Topics: Action Potentials; Animals; Calcium Channels, L-Type; Cerebellar Nuclei; gamma-Aminobutyric Acid; Glycine; Inhibitory Postsynaptic Potentials; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Resorcinols; Synapses; Synaptic Transmission; Thiophenes

2011
Medication dosing patterns associated with duloxetine and pregabalin among patients with fibromyalgia.
    Current medical research and opinion, 2011, Volume: 27, Issue:9

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Algorithms; Analgesics; Comorbidity; Databases, Factual; Dose-Response Relationship, Drug; Drug Costs; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Male; Medication Adherence; Middle Aged; Practice Patterns, Physicians'; Pregabalin; Retrospective Studies; Thiophenes; Young Adult

2011
Clinical comorbidities, treatment patterns, and healthcare costs among patients with fibromyalgia newly prescribed pregabalin or duloxetine in usual care.
    Journal of medical economics, 2012, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Analgesics; Comorbidity; Databases, Factual; Drug Therapy; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Health Expenditures; Humans; Male; Middle Aged; Pregabalin; Retrospective Studies; Thiophenes; United States; Young Adult

2012
Persistent genital arousal disorder: successful treatment with duloxetine and pregabalin in two cases.
    The journal of sexual medicine, 2012, Volume: 9, Issue:1

    Topics: Adult; Anticonvulsants; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Pregabalin; Selective Serotonin Reuptake Inhibitors; Sexual Dysfunction, Physiological; Thiophenes; Treatment Outcome

2012
Economic evaluation of duloxetine as a first-line treatment for painful diabetic peripheral neuropathy in Mexico.
    Journal of medical economics, 2012, Volume: 15, Issue:2

    Topics: Amines; Analgesics; Cost-Benefit Analysis; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Dopamine Uptake Inhibitors; Drug Costs; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Humans; Mexico; Pregabalin; Thiophenes

2012
Peripheral nerve toxic effects of nitrofurantoin.
    Archives of neurology, 2012, Volume: 69, Issue:2

    Topics: Amines; Analgesics; Anti-Infective Agents, Urinary; Biopsy; Cyclohexanecarboxylic Acids; Cystitis, Interstitial; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Middle Aged; Nerve Fibers; Neurologic Examination; Nitrofurantoin; Paresthesia; Perineum; Peripheral Nervous System Diseases; Psoriasis; Skin; Thiophenes; Treatment Outcome; Urinary Tract Infections

2012
Dosing pattern comparison between duloxetine and pregabalin among patients with diabetic peripheral neuropathic pain.
    Pain practice : the official journal of World Institute of Pain, 2012, Volume: 12, Issue:8

    Topics: Analgesics; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Practice Patterns, Physicians'; Pregabalin; Thiophenes

2012
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
    European journal of pain (London, England), 2012, Volume: 16, Issue:6

    Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Central Nervous System Stimulants; Cyclohexanecarboxylic Acids; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Ibuprofen; Lameness, Animal; Male; Morphine; Motor Activity; Neuritis; Rats; Rats, Sprague-Dawley; Thiophenes

2012
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:3

    Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxetine Hydrochloride; Exploratory Behavior; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Locomotion; Male; Morphine; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes

2012
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:1

    Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Morphine; Neuralgia; Neuroma; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley; Thiophenes; Time Factors

2012
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:1

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Interactions; Duloxetine Hydrochloride; Etodolac; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mexiletine; Mice; Paclitaxel; Peripheral Nervous System Diseases; Pregabalin; Thiophenes; Tissue Distribution

2012
A cost-utility analysis of pregabalin versus duloxetine for the treatment of painful diabetic neuropathy.
    Journal of pain & palliative care pharmacotherapy, 2012, Volume: 26, Issue:2

    Topics: Analgesics; Antidepressive Agents; Clinical Trials as Topic; Cost-Benefit Analysis; Decision Trees; Diabetic Neuropathies; Dose-Response Relationship, Drug; Drug Approval; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Models, Economic; Pregabalin; Quality-Adjusted Life Years; Thiophenes; United States; United States Food and Drug Administration

2012
Study of emotional and cognitive impairments in mononeuropathic rats: effect of duloxetine and gabapentin.
    Pain, 2012, Volume: 153, Issue:8

    Topics: Affective Symptoms; Amines; Analgesics; Animals; Antidepressive Agents; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Duloxetine Hydrochloride; Emotions; Gabapentin; gamma-Aminobutyric Acid; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Thiophenes; Treatment Outcome

2012
Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats.
    European journal of pain (London, England), 2013, Volume: 17, Issue:4

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; Nerve Growth Factor; Pain Threshold; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thiophenes; TRPV Cation Channels

2013
Duloxetine and pregabalin for pain management in multiple rheumatic diseases associated with fibromyalgia.
    Pain practice : the official journal of World Institute of Pain, 2013, Volume: 13, Issue:8

    Topics: Analgesics; Comorbidity; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Middle Aged; Pregabalin; Rheumatic Diseases; Thiophenes

2013
Direct medical costs and medication compliance among fibromyalgia patients: duloxetine initiators vs. pregabalin initiators.
    Pain practice : the official journal of World Institute of Pain, 2014, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Cohort Studies; Databases, Factual; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Health Care Costs; Humans; Male; Medication Adherence; Middle Aged; Pregabalin; Retrospective Studies; Thiophenes; Young Adult

2014
Retraumatization eliciting the presentation of fibromyalgia.
    The Israel Medical Association journal : IMAJ, 2013, Volume: 15, Issue:2

    Topics: Adult; Analgesics; Antidepressive Agents; Cannabinoids; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Pregabalin; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Stress, Psychological; Thiophenes; Uterine Rupture

2013
Add-on therapy: when two are not better than one.
    Pain, 2013, Volume: 154, Issue:12

    Topics: Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Male; Pain; Pregabalin; Thiophenes

2013
Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin.
    Arthritis care & research, 2013, Volume: 65, Issue:11

    Topics: Amines; Amitriptyline; Analgesics; Anti-Anxiety Agents; Antidepressive Agents; Cyclohexanecarboxylic Acids; Disease Progression; Duloxetine Hydrochloride; Female; Fibromyalgia; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pain Measurement; Pregabalin; Prescription Drugs; Retrospective Studies; Thiophenes; Treatment Outcome

2013
Possible drug-drug interaction between adalimumab and duloxetine and/or pregabalin in a psoriasis patient.
    Journal of drugs in dermatology : JDD, 2013, Volume: 12, Issue:10

    Topics: Adalimumab; Analgesics; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antidepressive Agents; Biological Products; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Drug Interactions; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Humans; Pregabalin; Psoriasis; Thiophenes; Young Adult

2013
Cost comparison of drug-drug and drug-condition interactions in patients with painful diabetic peripheral neuropathy treated with pregabalin versus duloxetine.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2013, Dec-15, Volume: 70, Issue:24

    Topics: Aged; Analgesics; Cohort Studies; Databases, Factual; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; gamma-Aminobutyric Acid; Health Care Costs; Humans; Male; Middle Aged; Pregabalin; Retrospective Studies; Thiophenes; United States

2013
Effectiveness of duloxetine compared with pregabalin and gabapentin in diabetic peripheral neuropathic pain: results from a German observational study.
    The Clinical journal of pain, 2014, Volume: 30, Issue:10

    Topics: Aged; Amines; Analgesics; Chi-Square Distribution; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Duloxetine Hydrochloride; Female; Gabapentin; gamma-Aminobutyric Acid; Germany; Health Surveys; Humans; Male; Middle Aged; Pain Measurement; Pregabalin; Prospective Studies; Thiophenes; Treatment Outcome

2014
Drugs for neuropathic pain.
    BMJ (Clinical research ed.), 2013, Dec-19, Volume: 347

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Therapy, Combination; Duloxetine Hydrochloride; Evidence-Based Medicine; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pregabalin; Thiophenes; Treatment Outcome

2013
Potential drug-drug and drug-condition interactions among fibromyalgia patients initiating pregabalin or duloxetine: prevalence and health care expenditure impact.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:8

    Topics: Adult; Analgesics; Cohort Studies; Drug Interactions; Duloxetine Hydrochloride; Female; Fibromyalgia; gamma-Aminobutyric Acid; Health Expenditures; Humans; Male; Middle Aged; Pregabalin; Prevalence; Retrospective Studies; Thiophenes

2014
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
    Journal of oral & facial pain and headache, 2014,Winter, Volume: 28, Issue:1

    Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Protocols; Cohort Studies; Cyclohexanecarboxylic Acids; Drug Combinations; Duloxetine Hydrochloride; Female; Follow-Up Studies; GABA-B Receptor Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Medical Records; Middle Aged; Nortriptyline; Pain; Pain Measurement; Pregabalin; Prognosis; Prospective Studies; Thiophenes; Treatment Outcome; Trigeminal Nerve Injuries; Trigeminal Neuralgia

2014
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex.
    Molecular psychiatry, 2014, Volume: 19, Issue:5

    Topics: Animals; Benzodiazepines; Benzoxazines; Central Nervous System Agents; Electric Stimulation; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Male; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Synaptic Transmission; Thiophenes

2014
Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine.
    European journal of pharmacology, 2014, Jul-15, Volume: 735

    Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Male; Neuralgia; Physical Stimulation; Pregabalin; Rats, Wistar; Sciatic Nerve; Thiophenes; Tramadol

2014
The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens.
    Psychopharmacology, 2014, Volume: 231, Issue:23

    Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Prefrontal Cortex; Quinuclidines; Rats; Rats, Sprague-Dawley; Thiophenes

2014
A mixed treatment comparison of gabapentin enacarbil, pramipexole, ropinirole and rotigotine in moderate-to-severe restless legs syndrome.
    Current medical research and opinion, 2014, Volume: 30, Issue:11

    Topics: Adult; Aged; Bayes Theorem; Benzothiazoles; Carbamates; Dopamine Agonists; Female; gamma-Aminobutyric Acid; Humans; Indoles; Male; Middle Aged; Pramipexole; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome

2014
Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens.
    ACS chemical neuroscience, 2014, Oct-15, Volume: 5, Issue:10

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cerebral Cortex; Cholinergic Agents; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Isoxazoles; Male; Models, Neurological; Neural Pathways; Neurons; Nucleus Accumbens; Phenylurea Compounds; Quinuclidines; Rats, Sprague-Dawley; Synapses; Thiophenes

2014
Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators.
    Journal of the American Chemical Society, 2015, Apr-08, Volume: 137, Issue:13

    Topics: 4-Aminobutyrate Transaminase; Drug Design; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Kinetics; Models, Molecular; Protein Conformation; Thiophenes

2015
Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain.
    Journal of oral & facial pain and headache, 2015,Summer, Volume: 29, Issue:3

    Topics: Administration, Oral; Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neuralgia; Propionates; Rats; Rats, Sprague-Dawley; Spinal Nerves; Thiophenes; Trigeminal Nerve

2015
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
    Pain, 2017, Volume: 158, Issue:1

    Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constriction, Pathologic; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Hypnotics and Sedatives; Idazoxan; Male; Motor Activity; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiophenes

2017
Dendrimer Conjugation Enables Multiphoton Chemical Neurophysiology Studies with an Extended π-Electron Caging Chromophore.
    Angewandte Chemie (International ed. in English), 2019, 08-26, Volume: 58, Issue:35

    Topics: Animals; Dendrimers; Electrons; gamma-Aminobutyric Acid; Induced Pluripotent Stem Cells; Mice; Neurons; Neurotransmitter Agents; Photons; Thiophenes

2019
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
    Nature communications, 2021, 02-22, Volume: 12, Issue:1

    Topics: Acute Disease; Animals; Basic-Leucine Zipper Transcription Factors; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; GABA Plasma Membrane Transport Proteins; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Humans; Inhibitory Postsynaptic Potentials; Isoquinolines; Kindling, Neurologic; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group D, Member 1; RNA, Messenger; Seizures; Small Molecule Libraries; Thiophenes

2021
Optimization of fermentation for γ-aminobutyric acid (GABA) production by yeast Kluyveromyces marxianus C21 in okara (soybean residue).
    Bioprocess and biosystems engineering, 2022, Volume: 45, Issue:7

    Topics: Fermentation; gamma-Aminobutyric Acid; Glycine max; Imidazoles; Kluyveromyces; Soy Foods; Sulfonamides; Thiophenes

2022
GABAergic interneurons' feedback inhibition of dorsal raphe-projecting pyramidal neurons of the medial prefrontal cortex suppresses feeding of adolescent female mice undergoing activity-based anorexia.
    Brain structure & function, 2022, Volume: 227, Issue:6

    Topics: Animals; Anorexia; Dorsal Raphe Nucleus; Feedback; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Imidazoles; Interneurons; Mice; Prefrontal Cortex; Pyramidal Cells; Sulfonamides; Thiophenes

2022
Validation of DREADD agonists and administration route in a murine model of sleep enhancement.
    Journal of neuroscience methods, 2022, Oct-01, Volume: 380

    Topics: Animals; Designer Drugs; Disease Models, Animal; gamma-Aminobutyric Acid; Imidazoles; Mice; Sleep; Sulfonamides; Thiophenes

2022
5-HT6 Receptors Sex-Dependently Modulate Hippocampal Synaptic Activity through GABA Inhibition.
    Biomolecules, 2023, 04-26, Volume: 13, Issue:5

    Topics: Animals; Female; gamma-Aminobutyric Acid; Hippocampus; Male; Mice; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Synaptic Transmission; Thiophenes

2023