Page last updated: 2024-08-18

thiophenes and folic acid

thiophenes has been researched along with folic acid in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	29 (54.72)	18.2507
2000's	15 (28.30)	29.6817
2010's	5 (9.43)	24.3611
2020's	4 (7.55)	2.80

Authors

Authors	Studies
Bader, H; Beardsley, GP; DeYarman, MT; Freisheim, JH; Galivan, J; Kerwar, SS; Moroson, BA; O'Connor, BM; Rosowsky, A; Russello, O	1
Brown, M; Calvert, AH; Gibson, W; Hughes, LR; Jackman, AL; Judson, IR; Kimbell, R; Taylor, GA	1
Calvert, AH; Gibson, W; Hughes, LR; Jodrell, DI; Newell, DR	1
Bensted, JP; Calvert, AH; Clinton, S; Hughes, LR; Jodrell, DI; Morgan, SE; Newell, DR	1
Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R	1
Calvert, AH; Freemantle, SJ; Jackman, AL; Kelland, LR; Lunec, J	1
Jansen, G; Peters, GJ; Pinedo, HM; Rijnboutt, S; Schornagel, JH; Westerhof, GR	1
Aherne, GW; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R	1
Chong, LK; Tattersall, MH	1
Erlichman, C; Mandelbaum, S; Mitrovski, B; Pressacco, J	1
Clarke, SJ; Jackman, AL; Judson, IR	1
Bavetsias, V; Bisset, GM; Calvert, AH; Gibson, W; Harrap, KR; Jackman, AL; Jodrell, DI; Kimbell, R; Smith, MN; Stephens, TC	1
Boyle, FT; Jackman, AL; McCloskey, ML; Smith, MN; Stephens, TC; Waterman, SE	1
Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R	1
Jackman, AL; Kobayashi, H; Miyachi, H; Skelton, L; Takemura, Y	1
Gibson, W; Jackman, AL; Kimbell, R; Kobayashi, H; Miyachi, H; Takemura, Y	1
Calvert, AH; Jackman, AL	1
Jansen, G; Jolivet, J; Kathmann, I; Molthoff, C; Pinard, MF; Ratnam, M; Schornagel, JH; Westerhof, R	1
Dabrowska, M; Michalski, R; Pawelczak, K; Rode, W; Wranicz, M; Zieliñski, Z	1
Rutenber, EE; Stroud, RM	1
Bavetsias, V; Bisset, GM; Boyle, FT; Jackman, AL; Marshall, D; Pedley, RB; Springer, CJ	1
Aherne, W; Clarke, S; Hardcastle, A	1
Kamen, B	1
Kobayashi, H; Ohnuma, T; Takemura, Y	1
Andis, SL; Bewley, JR; Chen, VJ; Iversen, PW; Mendelsohn, LG; Schultz, RM; Seitz, DE; Shih, C; Tonkinson, JL	2
Banerjee, D; Bertino, JR; Ercikan-Abali, EA; Liu-Chen, X; Maley, F; Tong, Y; Zhao, SC	1
Newell, DR	1
Danenberg, PV; Malli, H; Swenson, S	1
Aherne, GW; Benstead, J; Clarke, SJ; Farrugia, DC; Jackman, AL; Pritchard, DM	1
Strømhaug, A; Warren, DJ	1
Cassidy, J	1
Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D	1
Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH	1
Forsch, RA; Rosowsky, A; Wright, JE	1
Faessel, HM; Greco, WR; Rustum, YM; Slocum, HK	1
Jackman, AL; Theti, DS	1
Alfieri, S; Cellini, N; De Paoli, A; Di Miceli, D; Doglietto, GB; Gambacorta, MA; Mantini, G; Miccichè, F; Morganti, AG; Ratto, C; Rossi, C; Rotondi, F; Valentini, V; Vargas, JG	1
Goldman, ID; Wang, Y; Zhao, R	1
Fukushima, M; Hoogeland, MF; Peters, GJ; Temmink, OH	1
Assaraf, YG; Ifergan, I; Kadry, WN; Pinter, RY	1
Waldman, AS; Wyatt, MD; Yang, Z	1
Li, C; Shi, G; Yao, Z	1
Advincula, RC; Apodaca, DC; Del Mundo, FR; Pernites, RB; Ponnapati, RR	1
Li, X; Lu, Y; Yin, Z; Yu, Y; Zhao, X	1
Goldman, ID; Visentin, M; Zhao, R	1
Hal, TL; Jeong, SW; Kim, E; Kim, HC; Lee, B; Lee, SG; Lee, SJ; Lee, SW	1
Liu, H; Shi, L; Tong, G; Wang, D; Wu, J; Xu, L; Yan, D; Yu, C; Zhu, X	1
Chen, WJ; Dong, M; Feng, FD; Guan, HJ; Liu, JH; Liu, X; Shen, QD; Sun, C; Xia, QY; Yang, YN; Yu, ZH	1
Huang, G; Li, W; Liu, H; Luo, S; Lv, X; Wang, Y; Zhou, D	1
Chen, Y; Cui, Z; Ding, M; Fang, H; Li, H; Lin, Y; Ma, C; Niu, Q; Sun, H; Sun, S; Wang, S; Xiao, N; Xu, Y; Zhou, BS	1
Charushin, VN; Kovalev, IS; Majee, A; Santra, S; Varaksin, MV; Zyryanov, GV	1

Reviews

6 review(s) available for thiophenes and folic acid

Article	Year
Folate-based thymidylate synthase inhibitors as anticancer drugs. Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:9 Topics: Antineoplastic Agents; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	1995
Folate and antifolate pharmacology. Seminars in oncology, 1997, Volume: 24, Issue:5 Suppl 18 Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Trimetrexate	1997
Clinical pharmacokinetics of antitumor antifolates. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6 Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase	1999
Thymidylate synthase inhibitors. Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	1999
Thymidylate synthase inhibitors in colorectal cancer. Seminars in oncology, 2000, Volume: 27, Issue:5 Suppl 10 Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase	2000
Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities. Molecules (Basel, Switzerland), 2022, Sep-22, Volume: 27, Issue:19 Topics: Antimetabolites; Folic Acid; Folic Acid Antagonists; Methotrexate; Pemetrexed; Quinazolines; Thiophenes	2022

Trials

1 trial(s) available for thiophenes and folic acid

Article	Year
Chemoradiation with raltitrexed (Tomudex) in preoperative treatment of stage II-III resectable rectal cancer: a phase II study. International journal of radiation oncology, biology, physics, 2004, Sep-01, Volume: 60, Issue:1 Topics: Aged; Antimetabolites, Antineoplastic; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Hematinics; Humans; Male; Middle Aged; Neoplasm Staging; Quinazolines; Radiotherapy, Conformal; Rectal Neoplasms; Thiophenes	2004

Article

Year

Chemoradiation with raltitrexed (Tomudex) in preoperative treatment of stage II-III resectable rectal cancer: a phase II study.

International journal of radiation oncology, biology, physics, 2004, Sep-01, Volume: 60, Issue:1

Topics: Aged; Antimetabolites, Antineoplastic; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Hematinics; Humans; Male; Middle Aged; Neoplasm Staging; Quinazolines; Radiotherapy, Conformal; Rectal Neoplasms; Thiophenes

2004

Other Studies

46 other study(ies) available for thiophenes and folic acid

Article	Year
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism. Cancer research, 1992, Apr-15, Volume: 52, Issue:8 Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Male; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1992
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer research, 1991, Oct-15, Volume: 51, Issue:20 Topics: Animals; Carrier Proteins; Cell Division; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid; Glutamates; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase	1991
The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats. Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:5 Topics: Animals; Antineoplastic Agents; Blood Proteins; Chromatography, High Pressure Liquid; Female; Folic Acid; Folic Acid Antagonists; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Protein Binding; Quinazolines; Rats; Rats, Inbred Strains; Thiophenes; Time Factors; Tissue Distribution	1991
The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice. British journal of cancer, 1991, Volume: 64, Issue:5 Topics: Animals; Carbon Radioisotopes; Cisplatin; Creatinine; Female; Folic Acid; Glomerular Filtration Rate; Inulin; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidylate Synthase; Urea	1991
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines. British journal of cancer, 1995, Volume: 71, Issue:5 Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured	1995
Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694. British journal of cancer, 1995, Volume: 71, Issue:5 Topics: Antineoplastic Agents; Base Sequence; Blotting, Southern; Blotting, Western; DNA; DNA, Neoplasm; Drug Resistance; Female; Folic Acid; Humans; Lymphocytes; Molecular Sequence Data; Neoplasm Proteins; Ovarian Neoplasms; Polymerase Chain Reaction; Proteins; Quinazolines; RNA; RNA, Neoplasm; Thiophenes; Thymidylate Synthase; Transcription, Genetic; Tumor Cells, Cultured	1995
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein. Cancer research, 1995, Sep-01, Volume: 55, Issue:17 Topics: Aminopterin; Animals; Carrier Proteins; Cell Division; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Haplorhini; Humans; Kidney; Leucovorin; Methotrexate; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Quinazolines; Receptors, Cell Surface; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured	1995
Relationships between resistance to cisplatin and antifolates in sensitive and resistant tumour cell lines. European journal of cancer (Oxford, England : 1990), 1995, Volume: 31A, Issue:6 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Humans; Male; Ovarian Neoplasms; Quinazolines; Testicular Neoplasms; Thiophenes; Tumor Cells, Cultured; Uterine Cervical Neoplasms	1995
5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase. Biochemical pharmacology, 1995, Mar-15, Volume: 49, Issue:6 Topics: Animals; Cell Survival; Deoxyadenine Nucleotides; Drug Interactions; Floxuridine; Folic Acid; Hypoxanthine; Hypoxanthines; Leukemia L1210; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1995
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells. Cancer chemotherapy and pharmacology, 1994, Volume: 35, Issue:2 Topics: Cell Survival; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; In Vitro Techniques; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms	1994
The history of the development and clinical use of CB 3717 and ICI D1694. Advances in experimental medicine and biology, 1993, Volume: 339 Topics: Animals; Antimetabolites, Antineoplastic; Clinical Trials, Phase I as Topic; Folic Acid; History, 20th Century; Molecular Structure; Quinazolines; Thiophenes; Thymidylate Synthase; United Kingdom	1993
Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Antineoplastic Agents; Dipeptides; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase	1993
Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L5178; Mice; Mice, Inbred DBA; Mutation; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1993
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides	1993
Effect of hammerhead ribozyme against human thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitors. Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:11 Topics: B-Lymphocytes; Base Sequence; Drug Resistance; Drug Synergism; Enzyme Induction; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Molecular Sequence Data; Nucleic Acid Conformation; Quinazolines; Repetitive Sequences, Nucleic Acid; RNA, Catalytic; RNA, Messenger; Thiophenes; Thymidylate Synthase; Transfection; Trimetrexate	1995
Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug. Journal of cancer research and clinical oncology, 1996, Volume: 122, Issue:2 Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Humans; Intracellular Fluid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidylate Synthase; Tritium; Tumor Cells, Cultured	1996
Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate. Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:3 Topics: Aminopterin; Antimetabolites, Antineoplastic; Binding Sites; Breast Neoplasms; Carrier Proteins; Cell Membrane; DNA, Complementary; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Polymerase Chain Reaction; Quinazolines; Receptors, Cell Surface; RNA, Messenger; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured	1996
Trichinella spiralis thymidylate synthase: developmental pattern, isolation, molecular properties, and inhibition by substrate and cofactor analogues. Biochemical and biophysical research communications, 1996, Nov-12, Volume: 228, Issue:2 Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Fluorodeoxyuridylate; Folic Acid; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Larva; Liver; Liver Regeneration; Muscles; Quinazolines; Rats; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Trichinella spiralis	1996
Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity. Structure (London, England : 1993), 1996, Nov-15, Volume: 4, Issue:11 Topics: Antimetabolites, Antineoplastic; Binding Sites; Computer Simulation; Crystallography, X-Ray; Escherichia coli; Folic Acid; Folic Acid Antagonists; Humans; Models, Molecular; Molecular Conformation; Protein Conformation; Protein Structure, Secondary; Quinazolines; Species Specificity; Thiophenes; Thymidylate Synthase	1996
Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT). Anti-cancer drug design, 1996, Volume: 11, Issue:8 Topics: Antineoplastic Agents; Biotransformation; Carboxypeptidases; Carboxypeptidases A; Drug Delivery Systems; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Humans; Prodrugs; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1996
Interference by antifolate drugs in a folate competitive protein-binding assay. Cancer chemotherapy and pharmacology, 1997, Volume: 39, Issue:6 Topics: Folic Acid; Folic Acid Antagonists; Humans; Protein Binding; Quinazolines; Radioimmunoassay; Thiophenes	1997
Variable expression of RFC1 in human leukemia cell lines resistant to antifolates. Cancer letters, 1998, Feb-27, Volume: 124, Issue:2 Topics: Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Tumor Cells, Cultured	1998
Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. British journal of cancer, 1998, Volume: 78 Suppl 3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Nucleotides; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Reproducibility of Results; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1998
Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89. The Journal of biological chemistry, 1998, Nov-20, Volume: 273, Issue:47 Topics: Animals; Antimetabolites, Antineoplastic; Binding Sites; Bone Marrow Cells; Drug Resistance; Folic Acid; Folic Acid Antagonists; Granulocytes; Humans; Indoles; Isoindoles; Isoleucine; Kinetics; Macrophages; Mice; Models, Molecular; Mutagenesis, Site-Directed; Quinazolines; Recombinant Proteins; Stem Cells; Thiophenes; Thymidylate Synthase	1998
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6 Topics: Acid Anhydride Hydrolases; Antimetabolites, Antineoplastic; Deoxyribonucleotides; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Nucleoside-Diphosphate Kinase; Nucleoside-Triphosphatase; Pemetrexed; Quinazolines; Ribonucleotides; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured	1999
Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Deoxyuridine; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Folic Acid; Intestinal Mucosa; Intestine, Large; Intestine, Small; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Weight Loss	2000
A comparison of the effects of nine folate analogs on early and late murine hematopoietic progenitor cells in vitro. Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:6 Topics: Aminopterin; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Hematopoietic Stem Cells; Methotrexate; Mice; Mice, Inbred BALB C; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate	2000
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. Cancer research, 2001, May-01, Volume: 61, Issue:9 Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase	2001
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2 Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	2002
Synthesis and in vitro antitumor activity of thiophene analogues of 5-chloro-5,8-dideazafolic acid and 2-methyl-2-desamino-5-chloro-5,8-dideazafolic acid. Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:6 Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Inhibitory Concentration 50; Leukemia, Lymphoid; Molecular Structure; Spectrophotometry, Infrared; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured	2002
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells. International journal of oncology, 2003, Volume: 23, Issue:2 Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Folic Acid; Glutamates; Hematinics; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Ileal Neoplasms; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured	2003
The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Feb-01, Volume: 10, Issue:3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Models, Chemical; Neoplasms; Pemetrexed; Quinazolines; Receptors, Cell Surface; Thiophenes; Time Factors	2004
Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Sep-15, Volume: 10, Issue:18 Pt 1 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Blotting, Northern; Carrier Proteins; Cell Line; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Membrane Transport Proteins; Methotrexate; Pemetrexed; Protein Isoforms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; RNA; Thiophenes; Time Factors; Transfection; Trimetrexate	2004
Some antipsychotics' effect on suicide; duloxetine's promise for elderly. Behavioral healthcare tomorrow, 2004, Volume: 13, Issue:6 Topics: Aged; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Duloxetine Hydrochloride; Folic Acid; Humans; Suicide Prevention; Thiophenes; United States	2004
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:2 Topics: Antimetabolites; Colonic Neoplasms; DNA Damage; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homeostasis; Humans; Indoles; Isoindoles; Quinazolines; Thiophenes; Trifluridine; Tumor Cells, Cultured	2006
Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets. Journal of theoretical biology, 2006, Jun-21, Volume: 240, Issue:4 Topics: Antimetabolites, Antineoplastic; Computer Simulation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Chemical; Purines; Quinazolines; Signal Transduction; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate	2006
DNA damage and homologous recombination signaling induced by thymidylate deprivation. Biochemical pharmacology, 2008, Oct-15, Volume: 76, Issue:8 Topics: Cell Line, Tumor; Cell Survival; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Nucleotides; Phosphorylation; Quinazolines; Rad51 Recombinase; Recombination, Genetic; Replication Protein A; Thiophenes; Thymidine Monophosphate; Thymidylate Synthase	2008
Optically active supramolecular complexes of water-soluble achiral polythiophenes and folic acid: spectroscopic studies and sensing applications. Langmuir : the ACS journal of surfaces and colloids, 2008, Nov-18, Volume: 24, Issue:22 Topics: Absorption; Chemistry; Circular Dichroism; Colorimetry; Folic Acid; Hydrogen-Ion Concentration; Macromolecular Substances; Models, Chemical; Optics and Photonics; Polymers; Solubility; Spectrophotometry; Temperature; Thiophenes; Water	2008
Electropolymerized molecularly imprinted polymer films of a bis-terthiophene dendron: folic acid quartz crystal microbalance sensing. ACS applied materials & interfaces, 2011, Volume: 3, Issue:2 Topics: Biosensing Techniques; Dendrimers; Electrodes; Equipment Design; Folic Acid; Molecular Imprinting; Photoelectron Spectroscopy; Quartz Crystal Microbalance Techniques; Thiophenes	2011
Intestinal absorption of raltitrexed and evaluation of the effects of absorption enhancers. Die Pharmazie, 2013, Volume: 68, Issue:9 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acrylic Resins; Algorithms; Animals; Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Biological Availability; Caco-2 Cells; Decanoic Acids; Deoxycholic Acid; Excipients; Folic Acid; Humans; Intestinal Absorption; Male; Pantoprazole; Probenecid; Quinazolines; Rats; Rats, Wistar; Thiophenes; Verapamil	2013
Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis. Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:6 Topics: Cell Line, Tumor; Endocytosis; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; HeLa Cells; Humans; Pemetrexed; Proton-Coupled Folate Transporter; Quinazolines; Reduced Folate Carrier Protein; Thiophenes	2015
Folic Acid-Functionalized Polythiophene for Targeted Cellular Imaging. Journal of nanoscience and nanotechnology, 2016, Volume: 16, Issue:1 Topics: Drug Delivery Systems; Folic Acid; Humans; KB Cells; Materials Testing; Nanoparticles; Polymers; Thiophenes	2016
Nucleoside Analogue-Based Supramolecular Nanodrugs Driven by Molecular Recognition for Synergistic Cancer Therapy. Journal of the American Chemical Society, 2018, 07-18, Volume: 140, Issue:28 Topics: Animals; Antineoplastic Agents; Clofarabine; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Mice, Inbred BALB C; Mice, Nude; Molecular Dynamics Simulation; Nanoparticles; Neoplasms; Quinazolines; Rats; Thiophenes	2018
Folate-Modified Photoelectric Responsive Polymer Microarray as Bionic Artificial Retina to Restore Visual Function. ACS applied materials & interfaces, 2020, Jun-24, Volume: 12, Issue:25 Topics: Animals; Bionics; Folic Acid; Polymers; Prostheses and Implants; Rats; Retina; Thiophenes	2020
Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism. The Journal of nutritional biochemistry, 2021, Volume: 97 Topics: Aging; Animals; Apoptosis; Brain; Cognitive Dysfunction; Dietary Supplements; Folic Acid; Male; Memory; Mice; Morris Water Maze Test; Neurons; Quinazolines; Telomere Shortening; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Uracil	2021
A γ-glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells. FEBS letters, 2022, Volume: 596, Issue:4 Topics: Cell Line, Tumor; Cell Survival; CRISPR-Cas Systems; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Gene Editing; Glycosylation; HeLa Cells; Humans; Lymphocytes; Lysosomes; Methotrexate; Polyglutamic Acid; Protein Sorting Signals; Quinazolines; Thiophenes	2022