thiophenes has been researched along with eye in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (7.84) | 18.7374 |
| 1990's | 11 (21.57) | 18.2507 |
| 2000's | 18 (35.29) | 29.6817 |
| 2010's | 18 (35.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Zeeuw, RA; Drenth, BF; Gerding, TK; Horn, AS; Oosterhuis, JA; van Delft, JL | 1 |
| Biollaz, J; Brunner-Ferber, F; Buclin, T; Clineschmidt, C; Lippa, EA; Munafo, A; Schelling, JL; van Melle, G | 1 |
| Gautheron, P; Graham, SL; Mallorga, P; Nolan, TE; Schwam, H; Shepard, KL; Smith, RL; Sugrue, MF | 1 |
| Brunner-Ferber, FL; Hofmann, HM; Lippa, EA; von Denffer, HA | 1 |
| Gautheron, P; Grove, J; Plazonnet, B; Sugrue, MF | 1 |
| Burke, JA; Chan, MF; Crosson, CE; Potter, DE | 1 |
| Bosin, T; Campaigne, E | 1 |
| Conroy, CW; Maren, TH | 1 |
| Brechue, WF; Maren, TH | 2 |
| Dick, B; Pillunat, LE; Schmidt, KG; von Rückmann, A | 1 |
| Alm, A; Larsson, LI | 1 |
| Bauer, NJ; Hendrikse, F; March, WF; Motamedi, M; Webers, CA; Wicksted, JP | 1 |
| Capeans, C; Gonzalez, F; Martinez, A; Perez, R; Sanchez-Salorio, M | 1 |
| Becker, R; Pillunat, LE; Schmidt, KG; von Rückmann, A | 1 |
| Kobayashi, M; Naito, K | 1 |
| Herkel, U; Pfeiffer, N | 1 |
| Bernd, AS; Böhm, AG; Pillunat, LE; Richard, G; Schmidt, KG | 1 |
| Cole, C; Garzozi, H; Harris, A; Jonescu-Cuypers, CP; Kagemann, L; Martin, B; Nowacki, EA | 1 |
| Bergstrand, IC; Harris, A; Heijl, A | 1 |
| Bucci, MG; Centofanti, M; Gregori, D; Manni, G; Migliardj, R; Oddone, F; Scipioni, M | 1 |
| Recker, K | 1 |
| Brignoli, R; Mermoud, A; Ravinet, E | 1 |
| Aoyama, Y; Hada, N; Inoue, J; Kobayashi, S; Oka, M; Takeda, T; Takehana, M; Ueno, S | 1 |
| Harris, A; Janulevicienë, I; Kagemann, L; McCranor, L; Siesky, B | 1 |
| Eysteinsson, T; Gudmundsdóttir, E; Loftsson, T; Sigurdsson, HH; Stefánsson, E; Thorsteinsdóttir, M | 1 |
| Galambos, P; Klemm, M; Matthiessen, ET; Reuss, J; Richard, G; Wagenfeld, L; Wiermann, A; Zeitz, O | 1 |
| Aggermann, T; Buehl, W; Eichler, HG; Fuchsjäger-Mayrl, G; Kolodjaschna, J; Polska, E; Rainer, G; Schmetterer, L; Vass, C; Wally, B; Weigert, G | 1 |
| Martínez, A; Sánchez, M | 1 |
| Conkbayir, I; Simsek, T; Yanik, B; Zilelioglu, O | 1 |
| Harris, A; Malinovsky, VE; McCranor, L; Rechtman, E; Siesky, B; Sines, D; Yung, CW; Zalish, M | 1 |
| Almaden, CD; Anderson, S; Carreiro, S; Fortner, J; Gukasyan, H; Krauss, A; Lafontaine, J; Nair, S; Niesman, M; Prasanna, G; Rui, E; Sartnurak, S; Wells, P; Wu, G; Xiang, C; Zhang, E | 1 |
| Bwatwa, J; Ehrlich, R; Harris, A; Kagemann, L; McCranor, L; Miller, B; Regev, G; Siesky, B; Stefansson, E | 1 |
| Aguirre, SA; Huang, W; Jessen, B; Prasanna, G | 1 |
| Fang, Z; Liu, B; Zhan, R | 1 |
| Ammar, HO; Ghorab, M; Mahmoud, AA; Salama, HA | 1 |
| Bastien, NR; Behki, R; Boucher, S; Crichton, AC; Harasymowycz, P; Hutnik, CM; Ibrahim, F; Liao, C; Rifkind, AW; Sampalis, JS; Solomon, L | 1 |
| Ehrlich, R; Grabska-Liberek, I; Harris, A; Misiuk-Hojło, M; Mulak, M; Romanowska-Dixon, B; Sierdziński, J; Siesky, B; Stankiewicz, A; Szuścik, I; Wasyluk, J; Wierzbowska, J | 1 |
| Cabrita, AM; de Sousa, HC; Fontes Ribeiro, CA; Gaspar, MN; Gil, MH; Natu, MV | 1 |
| Jadhav, G; Kadam, RS; Kompella, UB; Ogidigben, M | 1 |
| Abrams, L; Cantor, L; Ehrlich, R; Harris, A; Hollander, DA; Rusia, D; Shoja, MM; Shoshani, Y; Siesky, B; Williams, JM | 1 |
| Ohguro, H; Ohguro, I | 1 |
| Feke, GT; Pasquale, LR; Rhee, DJ; Turalba, AV | 1 |
| Fukuda, M; Sasaki, H | 1 |
| Ha, SJ; Seo, du R | 1 |
| Aslan, CA; Baltepe Altıok, I; Eliacik, M; Gulkilik, G; Karaman Erdur, S; Kaya, F | 1 |
| Cong, X; Molloy, BL; Watson, C | 1 |
| Agelidis, A; Ames, J; Hadigal, S; Jaishankar, D; Shukla, D; Thakkar, N; Yadavalli, T; Yakoub, AM | 1 |
| Abdelrehim, RT; Fouda, NH; Habib, BA; Hegazy, DA | 1 |
| Kaur, G; Mittal, N | 1 |
| Cardoso, VN; Castilho, RO; Cronemberger, S; Faraco, AAG; Fernandes, SOA; Ferreira, AJ; Foureaux, G; Franca, JR; Fuscaldi, LL; Nogueira, JC; Ribeiro, TG; Yoshida, MI | 1 |
3 review(s) available for thiophenes and eye
| Article | Year |
|---|---|
[Pharmacological profiles of the potent carbonic anhydrase inhibitor dorzolamide hydrochloride, a topical antiglaucoma agent].
Topics: Animals; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Clinical Trials as Topic; Eye; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Rabbits; Sulfonamides; Thiophenes | 2000 |
Update on topical carbonic anhydrase inhibitors.
Topics: Antihypertensive Agents; Aqueous Humor; Blood Flow Velocity; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; Eye; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Sulfonamides; Thiazines; Thiophenes | 2001 |
Four years later: a clinical update on latanoprost.
Topics: Antihypertensive Agents; Aqueous Humor; Blood Flow Velocity; Circadian Rhythm; Clinical Trials as Topic; Drug Therapy, Combination; Eye; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ocular Hypertension; Prostaglandins F, Synthetic; Safety; Sulfonamides; Thiophenes; Timolol | 2003 |
19 trial(s) available for thiophenes and eye
| Article | Year |
|---|---|
Absence of metabolic effects of the topical carbonic anhydrase inhibitors MK-927 and sezolamide during two-week ocular administration to normal subjects.
Topics: Administration, Topical; Adult; Blood Pressure; Carbonic Anhydrase Inhibitors; Electrocardiography; Electrolytes; Eye; Heart Rate; Humans; Hydrogen-Ion Concentration; Kidney; Male; Ophthalmic Solutions; Sulfonamides; Thiophenes | 1991 |
Local tolerance and activity of MK-927, a novel topical carbonic anhydrase inhibitor.
Topics: Adult; Carbonic Anhydrase Inhibitors; Clinical Trials as Topic; Double-Blind Method; Eye; Humans; Hyperemia; Intraocular Pressure; Male; Ophthalmic Solutions; Placebos; Random Allocation; Sulfonamides; Thiophenes | 1988 |
Aqueous humor flow in human eyes treated with dorzolamide and different doses of acetazolamide.
Topics: Acetazolamide; Administration, Oral; Adult; Aqueous Humor; Bicarbonates; Carbonic Anhydrase Inhibitors; Contrast Media; Double-Blind Method; Drug Therapy, Combination; Eye; Female; Fluorescein; Fluorophotometry; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Reference Values; Sulfonamides; Thiophenes | 1998 |
Dorzolamide effect on ocular blood flow.
Topics: Aged; Carbonic Anhydrase Inhibitors; Eye; Glaucoma; Hemodynamics; Humans; Intraocular Pressure; Middle Aged; Reference Values; Regional Blood Flow; Sulfonamides; Thiophenes; Ultrasonography | 1999 |
[Ocular pulse amplitude, intraocular pressure and beta blocker/carbonic anhydrase inhibition in combined therapy of primary open-angle glaucoma].
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Pulsatile Flow; Sulfonamides; Thiophenes; Timolol | 1999 |
[Ocular hemodynamics and visual field in glaucoma treated with dorzolamide].
Topics: Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Eye; Female; Follow-Up Studies; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Retrospective Studies; Sulfonamides; Thiophenes; Visual Fields | 2001 |
Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Flow Velocity; Ciliary Arteries; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Eye; Fluorescein Angiography; Glaucoma, Open-Angle; Humans; Indocyanine Green; Intraocular Pressure; Laser-Doppler Flowmetry; Ophthalmic Artery; Ophthalmic Solutions; Ophthalmoscopy; Regional Blood Flow; Retinal Artery; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Ultrasonography; Visual Acuity | 2001 |
Dorzolamide and ocular blood flow in previously untreated glaucoma patients: a controlled double-masked study.
Topics: Administration, Topical; Aged; Aged, 80 and over; Blood Flow Velocity; Carbonic Anhydrase Inhibitors; Ciliary Arteries; Double-Blind Method; Eye; Female; Fluorescein Angiography; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Artery; Ophthalmic Solutions; Ophthalmoscopy; Retinal Artery; Sulfonamides; Thiophenes; Ultrasonography, Doppler, Color | 2002 |
A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Flow Velocity; Cross-Over Studies; Drug Therapy, Combination; Eye; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Middle Aged; Prostaglandins F, Synthetic; Pulsatile Flow; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Ultrasonography, Doppler | 2004 |
Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: a randomized trial comparing bimatoprost and latanoprost with dorzolamide [ISRCTN18873428].
Topics: Administration, Topical; Amides; Antihypertensive Agents; Bimatoprost; Blood Flow Velocity; Ciliary Arteries; Cloprostenol; Eye; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Latanoprost; Lipids; Ophthalmic Artery; Ophthalmic Solutions; Prospective Studies; Prostaglandins F, Synthetic; Regional Blood Flow; Retinal Artery; Single-Blind Method; Sulfonamides; Thiophenes; Ultrasonography, Doppler, Color | 2005 |
Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension.
Topics: Aged; Antihypertensive Agents; Choroid; Double-Blind Method; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Hemodynamics; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Middle Aged; Ocular Hypertension; Optic Disk; Regional Blood Flow; Regression Analysis; Retinal Vessels; Sulfonamides; Thiophenes; Timolol | 2005 |
A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Middle Aged; Prostaglandins F, Synthetic; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2006 |
Comparative analysis of the effects of brimonidine and dorzolamide on ocular blood flow velocity in patients with newly diagnosed primary open-angle glaucoma.
Topics: Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Brimonidine Tartrate; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Instillation, Drug; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Sulfonamides; Thiophenes; Treatment Outcome; Ultrasonography, Doppler, Color | 2006 |
A comparative analysis of the effects of the fixed combination of timolol and dorzolamide versus latanoprost plus timolol on ocular hemodynamics and visual function in patients with primary open-angle glaucoma.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Cross-Over Studies; Double-Blind Method; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol; Visual Acuity | 2006 |
Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Eye; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Middle Aged; Oximetry; Oxygen; Regional Blood Flow; Retina; Retinal Vessels; Sulfonamides; Thiophenes; Timolol; Ultrasonography, Doppler, Color | 2010 |
Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.
Topics: Adult; Aged; Aged, 80 and over; Amides; Antihypertensive Agents; Bimatoprost; Blood Flow Velocity; Blood Pressure; Circadian Rhythm; Cloprostenol; Drug Administration Schedule; Drug Therapy, Combination; Eye; Female; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Middle Aged; Ophthalmic Artery; Prospective Studies; Retinal Artery; Single-Blind Method; Sulfonamides; Thiophenes; Tonometry, Ocular; Ultrasonography, Doppler, Color | 2011 |
Short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and blood flow in glaucoma.
Topics: Administration, Ophthalmic; Aged; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Male; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2012 |
Effects of dorzolamide-timolol and brimonidine-timolol on retinal vascular autoregulation and ocular perfusion pressure in primary open angle glaucoma.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Homeostasis; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol | 2013 |
Preventive Dorzolamide-Timolol for Rising Intraocular Pressure During Steep Trendelenburg Position Surgery.
Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Drug Combinations; Eye; Female; Head-Down Tilt; Humans; Intraocular Pressure; Intraoperative Complications; Laparoscopy; Male; Middle Aged; Monitoring, Intraoperative; Ocular Hypertension; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2016 |
29 other study(ies) available for thiophenes and eye
| Article | Year |
|---|---|
Ocular and systemic disposition of the dopamine agonist N-0437 in monkeys after ocular administration.
Topics: Animals; Dopamine Agents; Eye; Macaca; Naphthalenes; Ophthalmic Solutions; Tetrahydronaphthalenes; Thiophenes | 1990 |
L-662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Ciliary Body; Eye; Female; In Vitro Techniques; Intraocular Pressure; Iris; Macaca fascicularis; Male; Rabbits; Sulfonamides; Thiophenes | 1990 |
Ocular distribution studies of the topical carbonic anhydrase inhibitors L-643,799 and L-650,719 and related alkyl prodrugs.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Chromatography, High Pressure Liquid; Ciliary Body; Conjunctiva; Cornea; Ethoxzolamide; Eye; Iris; Prodrugs; Rabbits; Tears; Thiazoles; Thiophenes | 1988 |
Ocular effects of a N,N-disubstituted 5-OH aminotetralin (N-0437): evidence for a dual mechanism of action.
Topics: Administration, Topical; Animals; Biomechanical Phenomena; Cebus; Dose-Response Relationship, Drug; Eye; Intraocular Pressure; Naphthalenes; Pupil; Rabbits; Tetrahydronaphthalenes; Thiophenes; Time Factors | 1987 |
Amides and esters of benzo[b]thiophene-2-carboxylic acid.
Topics: Acids; Amides; Anesthetics, Local; Animals; Benzene Derivatives; Eye; Rabbits; Thiophenes | 1967 |
Effect of pH on the ocular distribution of a topical carbonic anhydrase inhibitor.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Ciliary Body; Cornea; Eye; Half-Life; Hydrogen-Ion Concentration; Male; Rabbits; Sulfonamides; Thiophenes | 1995 |
pH and drug ionization affects ocular pressure lowering of topical carbonic anhydrase inhibitors.
Topics: Animals; Carbonic Anhydrase Inhibitors; Eye; Hydrogen-Ion Concentration; Imidazoles; Intraocular Pressure; Male; Ocular Hypertension; Ophthalmic Solutions; Osmolar Concentration; Rabbits; Solubility; Sulfonamides; Thiophenes | 1993 |
Carbonic anhydrase inhibitory activity and ocular pharmacology of organic sulfamates.
Topics: Animals; Carbonic Anhydrase Inhibitors; Eye; Hydrogen-Ion Concentration; Imidazoles; Intraocular Pressure; Rabbits; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids; Thiophenes | 1993 |
[Ocular pulse amplitude and local carbonic anhydrase inhibition].
Topics: Adult; Aged; Blood Pressure; Carbonic Anhydrase Inhibitors; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Pulsatile Flow; Regional Blood Flow; Sulfonamides; Thiophenes | 1997 |
Non-invasive assessment of ocular pharmacokinetics using Confocal Raman Spectroscopy.
Topics: Animals; Eye; Female; Rabbits; Spectrum Analysis, Raman; Sulfonamides; Thiophenes | 1999 |
The pulsatile ocular blood flow behaviour in open angle glaucoma patients after replacing timolol therapy with timolol and dorzolamide fixed combination: preliminary study.
Topics: Adrenergic beta-Antagonists; Aged; Blood Flow Velocity; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Pulsatile Flow; Sulfonamides; Thiophenes; Timolol | 2002 |
[Glaucoma: an ocular blood flow disorder?].
Topics: Adrenergic beta-Antagonists; Adult; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Eye; Female; Glaucoma; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Rheology; Risk Factors; Sulfonamides; Thiophenes; Time Factors; Timolol | 2003 |
Effects of dorzolamide hydrochloride on ocular tissues.
Topics: Animals; Blotting, Western; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Chromatography, High Pressure Liquid; Eye; Female; Immunohistochemistry; Instillation, Drug; Ophthalmic Solutions; Rabbits; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Tissue Distribution | 2004 |
Cyclodextrin formulation of dorzolamide and its distribution in the eye after topical administration.
Topics: Administration, Topical; Animals; Chemistry, Pharmaceutical; Cyclodextrins; Eye; Rabbits; Sulfonamides; Thiophenes | 2005 |
Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models.
Topics: Administration, Topical; Animals; Biological Availability; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Eye; Humans; Hydrolysis; Hyperemia; Intraocular Pressure; Models, Animal; Ophthalmic Solutions; Permeability; Prodrugs; Pyrrolidinones; Rabbits; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Transfection | 2009 |
Corneal neovascularization and ocular irritancy responses in dogs following topical ocular administration of an EP4-prostaglandin E2 agonist.
Topics: Administration, Topical; Animals; Cornea; Corneal Neovascularization; Dogs; Drug Combinations; Eye; Factor VIII; Intraocular Pressure; Pyrrolidinones; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Toxicity Tests; von Willebrand Factor | 2009 |
Naked-eye detection and quantification of heparin in serum with a cationic polythiophene.
Topics: Animals; Blood Chemical Analysis; Cattle; Circular Dichroism; Eye; Heparin; Lasers; Methanol; Optical Phenomena; Polymers; Polysaccharides; Scattering, Radiation; Temperature; Thiophenes; Water | 2010 |
Development of dorzolamide hydrochloride in situ gel nanoemulsion for ocular delivery.
Topics: Animals; Antihypertensive Agents; Biological Availability; Delayed-Action Preparations; Emulsions; Excipients; Eye; Gels; Male; Nanoparticles; Poloxamer; Rabbits; Sulfonamides; Surface-Active Agents; Thiophenes; Time Factors | 2010 |
Effectiveness of dorzolamide–timolol (COSOPT) in patients who were treatment naive for open-angle glaucoma or ocular hypertension: the COSOPT first-line study.
Topics: Aged; Drug Combinations; Eye; Female; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Multicenter Studies as Topic; Ocular Hypertension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Treatment Outcome | 2010 |
In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment.
Topics: Animals; Antihypertensive Agents; Calorimetry, Differential Scanning; Drug Carriers; Drug Implants; Eye; Glaucoma; Intraocular Pressure; Kinetics; Microscopy, Electron, Scanning; Polyesters; Polyethylene Glycols; Propylene Glycols; Rabbits; Solubility; Sulfonamides; Surface Properties; Thiophenes | 2011 |
Ocular pharmacokinetics of dorzolamide and brinzolamide after single and multiple topical dosing: implications for effects on ocular blood flow.
Topics: Administration, Topical; Animals; Carbonic Anhydrase Inhibitors; Chromatography, Liquid; Drug Administration Schedule; Eye; Male; Optic Nerve; Rabbits; Regional Blood Flow; Sulfonamides; Tandem Mass Spectrometry; Thiazines; Thiophenes | 2011 |
The effects of a fixed combination of 0.5% timolol and 1% dorzolamide on optic nerve head blood circulation.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Blood Pressure; Carbonic Anhydrase Inhibitors; Drug Combinations; Drug Synergism; Eye; Female; Heart Rate; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Optic Disk; Perfusion; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol; Young Adult | 2012 |
The transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes.
Topics: Animals; Benzalkonium Compounds; Chromatography, Liquid; Cloprostenol; Cornea; Drug Combinations; Eye; Glaucoma; Male; Ophthalmic Solutions; Preservatives, Pharmaceutical; Prostaglandins F, Synthetic; Rabbits; Sulfonamides; Thiophenes; Timolol | 2015 |
Comparison of Ocular Pulse Amplitude Lowering Effects of Preservative-Free Tafluprost and Preservative-Free Dorzolamide-Timolol Fixed Combination Eyedrops.
Topics: Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Preservatives, Pharmaceutical; Prostaglandins F; Retrospective Studies; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2015 |
Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma.
Topics: Aged; Carbonic Anhydrase Inhibitors; Cross-Sectional Studies; Drug Combinations; Exfoliation Syndrome; Eye; Female; Hemodynamics; Humans; Male; Middle Aged; Prospective Studies; Regional Blood Flow; Retinal Artery; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2016 |
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye.
Topics: Animals; Antiviral Agents; Disease Models, Animal; Enzyme Activation; Epithelium, Corneal; Eye; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice, Inbred BALB C; Proto-Oncogene Proteins c-akt; Pyrimidines; Swine; Thiophenes; Virion | 2018 |
Sustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic evaluation in rabbits.
Topics: Animals; Biological Availability; Chemistry, Pharmaceutical; Cholesterol; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Eye; Gels; Glaucoma; Intraocular Pressure; Liposomes; Male; Ophthalmic Solutions; Particle Size; Rabbits; Sulfonamides; Surface-Active Agents; Thiophenes | 2018 |
Leucaena leucocephala (Lam.) galactomannan nanoparticles: Optimization and characterization for ocular delivery in glaucoma treatment.
Topics: Adhesiveness; Animals; Drug Carriers; Drug Liberation; Eye; Fabaceae; Galactose; Glaucoma; Goats; Mannans; Nanoparticles; Permeability; Sulfonamides; Thiophenes | 2019 |
Chitosan/hydroxyethyl cellulose inserts for sustained-release of dorzolamide for glaucoma treatment: In vitro and in vivo evaluation.
Topics: Animals; Cellulose; Chitosan; Delayed-Action Preparations; Drug Delivery Systems; Eye; Glaucoma; Intraocular Pressure; Male; Ophthalmic Solutions; Polymers; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Tissue Distribution | 2019 |