Compounds > thiophenes
Page last updated: 2024-08-18

thiophenes and dinoprostone

thiophenes has been researched along with dinoprostone in 59 studies

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-19904 (6.78)18.7374
1990's8 (13.56)18.2507
2000's21 (35.59)29.6817
2010's23 (38.98)24.3611
2020's3 (5.08)2.80

Authors

AuthorsStudies
Duffy, EM; Jorgensen, WL1
Barr, RM; Black, AK; Dowd, PM; Greaves, MW; Isaacs, JL; Koro, O; Mistry, K1
Anderson, PS; Raisz, LG; Rodan, GA; Shepard, KL; Simmons, HA; Thompson, WJ1
Asai, F; Schrör, K1
Lefort, J; Randon, J; Vargaftig, BB1
Conroy, MC; Finkel, M; Grabow, D; Lesch, M; Low, J; Metz, A; Schrier, D; Sommers, C; Wallace, J1
Cooper, P; MacKenzie, A; Schnyder, J1
Catalioto, RM; Criscuoli, M; Giachetti, A; Porchia, R; Renzetti, AR; Subissi, A1
Masferrer, JL; Needleman, P; Salvemini, D; Seibert, K1
Chou, TC; Ding, YA; Hsu, LY; Yen, MH1
Bayly, C; Mancini, JA; Riendeau, D; Waterman, HL; Wong, E1
Reddy, BS1
Alcaraz, MJ; González, LM; Peinador, C; Quintela, JM; Riguera, R; Rioja, I; Terencio, MC; Ubeda, A1
Danon, A; Rimon, G; Rosenstock, M; Rubin, M1
Gallant, M; Harada, S; Hutchins, S; Labelle, M; Lachance, N; Leu, CT; Machwate, M; Metters, KM; Rodan, GA; Rodan, SB; Sawyer, N; Seedor, G; Slipetz, D; Young, R1
Comp, PC; Funahashi, T; Igarashi, H; Kincade, PW; Matsuzawa, Y; Medina, KL; Meka, CS; Miyagawa, J; Nishida, M; Oritani, K; Takahashi, M; Tomiyama, Y; Yokota, T1
Izon, DJ; Loftin, C; Spain, LM; Xu, H1
Balsamo, A; Coletta, I; Guglielmotti, A; Landolfi, C; Mancini, F; Martinelli, A; Milanese, C; Minutolo, F; Nencetti, S; Orlandini, E; Pinza, M; Rapposelli, S; Rossello, A1
Andre, N; Bellot, I; Briss, S; Deschamps, C; Droual, M; Sauveur, F; Tordjman, C; Wierzbicki, M1
Andre, N; Bellot, I; Bresson, Y; Deschamps, C; Pastoureau, P; Tordjman, C; Wierzbicki, M1
Balsamo, A; Lapucci, A; Minutolo, F; Orlandini, E; Ortore, G; Pinza, M; Rapposelli, S1
Bader, M; Cahová, M; Cervenka, L; Ganten, D; Husková, Z; Komers, R; Kramer, HJ; Skaroupková, P; Vanecková, I1
Abdel-Hakim, K; El-Nefiawy, N; Kanayama, N1
Kamio, K; Kawasaki, S; Kobayashi, T; Liu, X; Mao, LJ; Rennard, SI; Shen, L; Sugiura, H; Togo, S; Wang, XQ1
Alander, C; Choudhary, S; Halbout, P; Pilbeam, C; Raisz, L1
Aquino, M; Bruno, I; Gomez-Paloma, L; Guerrero, MD; Paya, M; Riccio, R; Terencio, MC1
Chen, XB; Cherukuri, DP; Goulet, AC; Han, Y; Heimark, RL; Meuillet, E; Nelson, MA; Regan, JW; Young, RN1
Babad, JM; Garay, M; Liebel, FT; Southall, MD; Sur, R1
Baydoun, AR; Churchman, A; Hoffman, R1
Cicha, MZ; Hökfelt, T; Kopp, UC; Mulder, J; Smith, LA1
Arnold, B; Kolaczkowska, E; Opdenakker, G; Piccard, H; Plytycz, B1
Flood, P; Hong, JS; Hu, X; Langenbach, R; Lee, C; Qian, L; Wilson, B; Zhang, D1
Barnett, JM; Clark, ML; Penn, JS; Yanni, SE1
Andrés, RM; Aquino, M; Bruno, I; De Simone, R; Guerrero, MD; Paya, M; Riccio, R; Terencio, MC1
Colucci, M; Di Giannuario, A; Maione, F; Mascolo, N; Mastriota, M; Palmery, M; Perretti, M; Pieretti, S; Severini, C1
Chen, Z; Doyle, T; Muscoli, C; Obeid, LM; Salvemini, D1
Christman, JW; van Breemen, RB; Xiao, L; Yu, R; Zhao, G1
Fuskevåg, OM; Gogvadze, V; Johnsen, JI; Kock, A; Kogner, P; Kruspig, B; Rasmuson, A; Simón-Santamaría, J; Sveinbjörnsson, B1
Elmes, SJ; McIntosh, F; Perkins, MN; Rashid, MH; Theberge, Y1
Cao, H; Christman, JW; Deng, J; Li, Y; Ornatowska, M; Sadikot, RT; Xiao, L; Yu, R; Zhao, G; Zhao, Q1
Li, X; Li, Y; Tan, L; Tang, T; Wang, J; Wu, Y; Xu, Z; Yang, P; Zhao, L; Zhao, Z1
Battani, KA; Lindgren, CA; Morford, JJ; Newman, ZL; Ryan, SB; Su, Z1
Gu, Y; Han, Y; Ma, G; Shi, H; Tang, C; Wang, Q; Yan, G1
Ireland, DJ; Keelan, JA; Kemp, MW; Newnham, JP; Payne, MS; Stinson, LF; Stock, SJ1
Boonmars, T; Chusorn, P; Jongthawin, J; Khuntikeo, N; Loilome, W; Namwat, N; Puapairoj, A; Tassaneeyakul, W; Techasen, A; Thanan, R; Yongvanit, P1
Jin, YH; Jin, Z; Kim, S; Lee, G; Park, CS; Park, YS1
Gallego, D; Jimenez, M; Mañé, N; Martin, MT; Martinez-Cutillas, M1
Cai, Y; Libby, P; Rocha, VZ; Shimizu, K; Sukhova, GK; Tang, EH; Vanhoutte, PM; Wong, CK; Xu, A; Xuan, G1
Bonewald, L; Brotto, M; Igwe, O; Mo, C; Vallejo, J; Wetmore, L; Zhao, R1
Antczak, MI; Bae, KB; Chance, M; Chen, WD; Cominelli, F; Dawson, DM; Dealwis, C; Desai, A; Di Martino, L; Djuric, Z; Fink, SP; Gerson, SL; He, L; Kasturi, L; Larusch, GA; Markowitz, SD; Mikkola, D; Milne, GL; Naidoo, J; Posner, B; Ready, JM; Sanabria, J; Tai, HH; Tiwari, S; Wald, D; Wang, Z; Wei, S; Williams, NS; Willis, JE; Willson, JK; Yang, SY; Zhang, Y1
Allison, S; Hoang, KG; Murray, M; Petrovic, N1
Chow, KBS; Tse, KH; Wise, H1
Han, G; Li, W; Li, X; Yang, B1
Chen, L; Li, D; Wu, X; Zhong, J1
Araldi, D; Ferrari, LF; Levine, JD1
Cao, X; Cao, Y; Chai, Y; Chen, H; Deng, R; Dong, X; Gao, B; Guan, Y; Hu, B; Jain, A; Liu, S; Lv, X; Ni, S; Wan, M; Wang, L; Wang, X; Yang, H; Yang, M; Yuan, W; Zhen, G; Zhu, S1
Bärnthaler, T; Flick, H; Heinemann, A; Klepetko, W; Kwapiszewska, G; Lanz, I; Olschewski, H; Scheidl, S; Schuligoi, R; Sinn, K; Stacher-Priehse, E; Theiler, A; Thomas, D; Trautmann, S; Zabini, D1
Christo, KF; Desai, AB; Jogasuria, AP; Markowitz, SD; Raffay, TM; Smith, JNP; Witkin, MD1
Dinkova-Kostova, AT; Epemolu, O; Gazaryan, IG; Mak, KK; Mohd, Z; Pichika, MR; Sakirolla, R; Shiming, Z; Wells, G1

Reviews

1 review(s) available for thiophenes and dinoprostone

ArticleYear
Chemoprevention of colon cancer by dietary administration of naturally-occurring and related synthetic agents.
    Advances in experimental medicine and biology, 1997, Volume: 400B

    Topics: Allyl Compounds; Anethole Trithione; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Arachidonic Acids; Aspirin; Colon; Colonic Neoplasms; Dinoprostone; Disulfides; Eflornithine; Food, Fortified; Ibuprofen; Intestinal Mucosa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Piroxicam; Pyrazines; Thiones; Thiophenes

1997

Other Studies

58 other study(ies) available for thiophenes and dinoprostone

ArticleYear
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
The in vitro 5-lipoxygenase and cyclo-oxygenase inhibitor L-652,343 does not inhibit 5-lipoxygenase in vivo in human skin.
    British journal of clinical pharmacology, 1988, Volume: 25, Issue:1

    Topics: Adult; Arachidonate Lipoxygenases; Cyclooxygenase Inhibitors; Dinoprostone; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Psoriasis; Skin; Thiophenes

1988
Effects of a potent carbonic anhydrase inhibitor on bone resorption in organ culture.
    Endocrinology, 1988, Volume: 122, Issue:3

    Topics: Acetazolamide; Animals; Bone and Bones; Bone Resorption; Calcitriol; Calcium Radioisotopes; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Dinoprostone; Ethoxzolamide; Interleukin-1; Organ Culture Techniques; Parathyroid Hormone; Prostaglandins E; Rats; Thiophenes

1988
Different effects of thromboxane synthetase inhibition on PGI2 and PGE2 synthesis in human vascular tissue bathed in clotting blood.
    Progress in clinical and biological research, 1987, Volume: 242

    Topics: Blood Coagulation; Dinoprostone; Epoprostenol; Humans; Imidazoles; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Prostaglandins E; Pyridines; Thiophenes; Thromboxane-A Synthase; Umbilical Arteries

1987
Comparison between the antiaggregating effect of ticlopidine in whole blood, platelet-rich plasma and washed platelets of the rat.
    Thrombosis research, 1982, Apr-01, Volume: 26, Issue:1

    Topics: Adenosine Diphosphate; Animals; Dinoprostone; Epoprostenol; In Vitro Techniques; Male; Plasma; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Thiophenes; Ticlopidine

1982
Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion.
    Gastroenterology, 1995, Volume: 109, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Adhesion; Dinoprostone; Dogs; Ethanol; Female; Gastric Acid; Gastric Mucosa; Histamine Antagonists; Indomethacin; Leukocytes; Leukotriene C4; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfhydryl Compounds; Tetrazoles; Thiophenes

1995
Modulation of secretory processes of phagocytes by IX 207-887.
    Springer seminars in immunopathology, 1993, Volume: 14, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokines; Dexamethasone; Dimethyl Sulfoxide; Dinoprostone; Humans; Inflammation; Macrophages; Mice; Monocytes; Neutrophils; Phagocytes; Rats; Respiratory Burst; Secretory Rate; Thiophenes

1993
Angiotensin II-induced responses in vascular smooth muscle cells: inhibition by non-peptide receptor antagonists.
    European journal of pharmacology, 1995, Jul-14, Volume: 280, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Cells, Cultured; Dinoprostone; DNA; Epoprostenol; Imidazoles; Inositol 1,4,5-Trisphosphate; Leucine; Losartan; Male; Muscle, Smooth, Vascular; Protein Biosynthesis; Pyridines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tetrazoles; Thiophenes; Thymidine

1995
Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney.
    British journal of pharmacology, 1996, Volume: 117, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Hydronephrosis; Isoenzymes; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Rabbits; Recombinant Proteins; Thiophenes

1996
The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation.
    Thrombosis research, 1996, Oct-15, Volume: 84, Issue:2

    Topics: Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Dinoprostone; Fura-2; Humans; Ketones; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thiophenes; Thromboxane B2

1996
Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation.
    The Journal of biological chemistry, 1997, Apr-04, Volume: 272, Issue:14

    Topics: Amino Acid Sequence; Arginine; Binding Sites; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Histidine; Humans; Isoenzymes; Isoleucine; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Sulfonamides; Thiophenes; Valine

1997
Synthesis and pharmacological evaluation of some 8-cyanopyrido[3', 2':4,5]thieno[3,2-d]triazine derivatives as inhibitors of nitric oxide and eicosanoid biosynthesis.
    Journal of medicinal chemistry, 1999, Nov-04, Volume: 42, Issue:22

    Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Isoenzymes; Macrophages, Peritoneal; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Thiophenes; Triazines

1999
Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs.
    European journal of pharmacology, 2001, Jan-19, Volume: 412, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Ibuprofen; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sulfonamides; Thiophenes

2001
Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).
    Molecular pharmacology, 2001, Volume: 60, Issue:1

    Topics: Animals; Bone and Bones; Cells, Cultured; Dinoprostone; Humans; Male; Periosteum; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Sulfhydryl Compounds; Thiophenes

2001
Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins.
    The Journal of clinical investigation, 2002, Volume: 109, Issue:10

    Topics: 3T3 Cells; Adipocytes; Adiponectin; Adipose Tissue, Brown; Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Intercellular Signaling Peptides and Proteins; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Paracrine Communication; Prostaglandin-Endoperoxide Synthases; Proteins; Recombinant Proteins; Thiophenes

2002
The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition.
    Cellular immunology, 2001, Dec-15, Volume: 214, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Immunologic Deficiency Syndromes; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Nitrobenzenes; Organ Culture Techniques; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Sulfonamides; T-Lymphocytes; Thiophenes; Thymus Gland

2001
Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.
    European journal of medicinal chemistry, 2003, Volume: 38, Issue:2

    Topics: Amines; Animals; Binding Sites; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopentanes; Dinoprostone; Humans; Isoenzymes; Isoxazoles; Macrophages; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Structure-Activity Relationship; Thiophenes; U937 Cells

2003
Synthesis of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:11

    Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Calcimycin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Indicators and Reagents; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Mice; Neutrophils; Prostaglandin-Endoperoxide Synthases; Rats; Thiophenes

2003
General pharmacology of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:12

    Topics: Acetic Acid; Air; Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Hot Temperature; Hyperalgesia; Lipoxygenase Inhibitors; Male; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Reaction Time; Stomach Diseases; Thiophenes

2003
Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs.
    Farmaco (Societa chimica italiana : 1989), 2004, Volume: 59, Issue:1

    Topics: Amides; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Design; Drug Evaluation, Preclinical; Humans; Isoenzymes; Isoxazoles; Macrophages; Membrane Proteins; Molecular Conformation; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Structure-Activity Relationship; Thiophenes

2004
Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake.
    Kidney & blood pressure research, 2004, Volume: 27, Issue:4

    Topics: Animals; Animals, Genetically Modified; Blood Pressure; Cyclooxygenase Inhibitors; Diet, Sodium-Restricted; Dinoprostone; Glomerular Filtration Rate; Kidney Cortex; Male; Nitrobenzenes; Rats; Renal Circulation; Renin; Renin-Angiotensin System; Sodium, Dietary; Sulfonamides; Thiophenes

2004
The selective prostaglandin EP4 agonist, APS-999 Na, induces follicular growth and maturation in the rat ovary.
    European journal of endocrinology, 2005, Volume: 152, Issue:2

    Topics: Animals; Dinoprostone; Female; Gonadotropins, Equine; Immunohistochemistry; Interleukin-8; Ovarian Follicle; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Sulfhydryl Compounds; Thiophenes

2005
Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation.
    Journal of cellular physiology, 2007, Volume: 210, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Apoptosis; Carbazoles; Caspases; Cell Line; Cyclic AMP-Dependent Protein Kinases; Dideoxyadenosine; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Indoles; Lung; Nicotiana; Pyrroles; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; RNA, Small Interfering; Signal Transduction; Smoke; Thiophenes; Triazoles

2007
Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: involvement of prostaglandins.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007, Volume: 22, Issue:7

    Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone Marrow Cells; Calcification, Physiologic; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Female; Gene Expression Regulation, Enzymologic; Male; Mice; Nitrobenzenes; Organometallic Compounds; Osteoblasts; Stromal Cells; Sulfonamides; Thiophenes; Time Factors

2007
Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prosta
    Journal of medicinal chemistry, 2007, May-03, Volume: 50, Issue:9

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Combinatorial Chemistry Techniques; Cyclooxygenase 2; Dinoprostone; Female; Furans; Humans; Intramolecular Oxidoreductases; Mice; Microsomes; NF-kappa B; Phospholipases A; Phospholipases A2; Prostaglandin Antagonists; Prostaglandin-E Synthases; Structure-Activity Relationship; Thiophenes

2007
The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
    Experimental cell research, 2007, Aug-15, Volume: 313, Issue:14

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclic AMP Response Element-Binding Protein; Dinoprostone; Early Growth Response Protein 1; Extracellular Signal-Regulated MAP Kinases; Humans; Promoter Regions, Genetic; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Thiophenes; Transcription, Genetic; Triazoles

2007
Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:2

    Topics: Acne Vulgaris; Animals; Anti-Inflammatory Agents; Antifungal Agents; Biopsy; Carcinogens; Cell Line; Cyclooxygenase 2; Cytokines; Dermatitis, Contact; Dinoprostone; Enzyme Activation; Gram-Positive Bacterial Infections; Humans; Imidazoles; Irritants; Keratinocytes; Leukocytes, Mononuclear; Mice; p38 Mitogen-Activated Protein Kinases; Propionibacterium acnes; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes

2008
Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697).
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase Inhibitors; Cells, Cultured; Chromatin Assembly and Disassembly; Collagen; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Endothelial Cells; Flow Cytometry; Humans; Indomethacin; Laminin; Neovascularization, Physiologic; Oligopeptides; Proteoglycans; Thiophenes; Vascular Endothelial Growth Factor A

2007
Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 293, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Fibers; Animals; Calcitonin Gene-Related Peptide; Dinoprostone; Indomethacin; Kidney; Male; Neurons, Afferent; Neurons, Efferent; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Substance P; Thiophenes; Triazoles

2007
Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.
    Immunology, 2009, Volume: 128, Issue:1 Suppl

    Topics: Animals; Apoptosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Peritonitis; Prostaglandin D2; Pyrazoles; Thiophenes; Zymosan

2009
Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro.
    Toxicology and applied pharmacology, 2009, Jul-01, Volume: 238, Issue:1

    Topics: Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Prostaglandin Antagonists; Rats; Rats, Inbred F344; Thiophenes; Xanthones

2009
The role of PGE2 receptor EP4 in pathologic ocular angiogenesis.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:11

    Topics: Animals; Animals, Newborn; Cell Proliferation; Choroid; Choroidal Neovascularization; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Humans; Laser Coagulation; Male; Mice; Neuroglia; Oxygen; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Retinal Neovascularization; Retinal Vessels; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A

2009
Toward the discovery of new agents able to inhibit the expression of microsomal prostaglandin E synthase-1 enzyme as promising tools in drug development.
    Chemical biology & drug design, 2010, Volume: 76, Issue:1

    Topics: 4-Butyrolactone; Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Drug Discovery; Gene Expression; Intramolecular Oxidoreductases; Macrophages; Mice; Microsomes; Oleanolic Acid; Prostaglandin-E Synthases; Thiophenes

2010
Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.
    Peptides, 2011, Volume: 32, Issue:2

    Topics: Animals; Atropine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Motility; Gastrointestinal Transit; Guinea Pigs; Ileum; Lower Gastrointestinal Tract; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Oligopeptides; Piperidines; Piroxicam; Prostaglandins; Quinuclidines; Tetrodotoxin; Thiophenes; Upper Gastrointestinal Tract

2011
Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011, Volume: 25, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Ceramides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Extremities; Hot Temperature; Hyperalgesia; Imidazoles; Injections; Male; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes; Touch

2011
Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:2

    Topics: 4-Butyrolactone; Animals; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dibenzocycloheptenes; Dinoprostone; Enzyme Assays; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Isomerases; Lipocalins; Macrophages; Mice; Mice, Inbred C57BL; Piperidines; Prostaglandin D2; Prostaglandin H2; Prostaglandin-E Synthases; Sheep; Thiophenes

2011
Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.
    PloS one, 2012, Volume: 7, Issue:1

    Topics: 16,16-Dimethylprostaglandin E2; Autocrine Communication; Biphenyl Compounds; Blotting, Western; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclic AMP; Cyclooxygenase 2 Inhibitors; Dinoprostone; Humans; Immunohistochemistry; In Vitro Techniques; Neuroblastoma; Phosphorylation; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Reverse Transcriptase Polymerase Chain Reaction; Tandem Mass Spectrometry; Thiophenes; Triazoles

2012
Pharmacological validation of early and late phase of rat mono-iodoacetate model using the Tekscan system.
    European journal of pain (London, England), 2013, Volume: 17, Issue:2

    Topics: Alkylating Agents; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chronic Disease; Dexamethasone; Dinoprostone; Disease Models, Animal; Duloxetine Hydrochloride; Hindlimb; Iodoacetates; Male; Morphine; Muscle Fibers, Skeletal; Naproxen; Neurons, Afferent; Pain Measurement; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Restraint, Physical; Synovial Fluid; Thiophenes; Weight-Bearing

2013
Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: 4-Butyrolactone; Animals; Cyclooxygenase 1; Dinoprostone; Enzyme Inhibitors; Gene Expression Regulation; Intramolecular Oxidoreductases; Lipocalins; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Microsomes; Nitric Oxide Synthase Type II; Primary Cell Culture; Prostaglandin D2; Prostaglandin-E Synthases; Proto-Oncogene Proteins; RNA, Small Interfering; Thiophenes; Trans-Activators

2012
Coculture with endothelial cells enhances osteogenic differentiation of periodontal ligament stem cells via cyclooxygenase-2/prostaglandin E2/vascular endothelial growth factor signaling under hypoxia.
    Journal of periodontology, 2013, Volume: 84, Issue:12

    Topics: Angiogenesis Inhibitors; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endothelial Cells; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Nitrobenzenes; Osteogenesis; Periodontal Ligament; Prostaglandin Antagonists; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Stem Cells; Sulfonamides; Thiophenes; Triazoles; Vascular Endothelial Growth Factor A; Xanthones

2013
Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction.
    The Journal of physiology, 2013, Oct-01, Volume: 591, Issue:19

    Topics: Animals; Arachidonic Acids; Benzoates; Capsaicin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endocannabinoids; Glycerides; Imidazoles; Lizards; Miniature Postsynaptic Potentials; Muscarine; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Schwann Cells; Sulfonamides; Thiophenes; Xanthones

2013
Regulation of rat intrapulmonary arterial tone by arachidonic acid and prostaglandin E2 during hypoxia.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Animals; Arachidonic Acid; Calcium; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Hypoxia; Male; Muscle Tonus; Oxytocics; Pulmonary Artery; Rats; Rats, Wistar; Receptors, Prostaglandin E; Thiophenes; Triazoles; Vasoconstriction; Xanthones

2013
Effects of cytokine-suppressive anti-inflammatory drugs on inflammatory activation in ex vivo human and ovine fetal membranes.
    Reproduction (Cambridge, England), 2014, Volume: 147, Issue:3

    Topics: Acetylcysteine; Amides; Animals; Anti-Inflammatory Agents; Cell-Penetrating Peptides; Cells, Cultured; Cytokines; Dinoprostone; Extraembryonic Membranes; Female; Humans; Imidazoles; Inflammation; Pregnancy; Pyrimidines; Sheep; Thiophenes

2014
PGE2 signaling and its biosynthesis-related enzymes in cholangiocarcinoma progression.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:8

    Topics: 4-Butyrolactone; Adult; Aged; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Cyclooxygenase 2; Dinoprostone; Female; Humans; Intramolecular Oxidoreductases; Male; Middle Aged; Prostaglandin-E Synthases; Signal Transduction; Thiophenes

2014
Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons.
    Biochemical and biophysical research communications, 2015, Jan-02, Volume: 456, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Carbazoles; Dinoprostone; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Ileum; Male; Neurons, Afferent; Nodose Ganglion; Ondansetron; Patch-Clamp Techniques; Prostaglandins; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT3; Sensory Receptor Cells; Serotonin; Signal Transduction; Stomach; Thiophenes; Triazoles; Visceral Afferents; Xanthones

2015
EP2 and EP4 receptors mediate PGE2 induced relaxation in murine colonic circular muscle: pharmacological characterization.
    Pharmacological research, 2014, Volume: 90

    Topics: Alprostadil; Animals; Azetidines; Colon; Dinoprostone; Female; In Vitro Techniques; Male; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles

2014
Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue.
    Journal of lipid research, 2015, Volume: 56, Issue:2

    Topics: Adipose Tissue; Animals; Chemokine CCL3; Chemokine CXCL10; Chemokines; Dinoprostone; In Vitro Techniques; Interleukin-10; Interleukin-6; Interleukin-8; Male; Pyrrolidinones; Receptors, Prostaglandin E, EP4 Subtype; Serum Amyloid A Protein; Signal Transduction; Tetrazoles; Thiophenes; Triazoles

2015
Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation.
    Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:10

    Topics: Acetylcysteine; Alprostadil; Animals; Cell Proliferation; Cells, Cultured; Dinoprostone; G1 Phase Cell Cycle Checkpoints; Immunohistochemistry; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts; Reactive Oxygen Species; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Thiophenes; Triazoles

2015
TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
    Science (New York, N.Y.), 2015, Jun-12, Volume: 348, Issue:6240

    Topics: Animals; Bone Marrow Transplantation; Colitis; Dinoprostone; Enzyme Inhibitors; Hematopoiesis; Hydroxyprostaglandin Dehydrogenases; Liver Regeneration; Mice; Mice, Knockout; Prostaglandins; Pyridines; Regeneration; Thiophenes

2015
Prostanoids regulate angiogenesis acting primarily on IP and EP4 receptors.
    Microvascular research, 2015, Volume: 101

    Topics: Benzyl Compounds; Cell Movement; Dinoprostone; Endothelial Cells; Epoprostenol; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Neovascularization, Pathologic; Neovascularization, Physiologic; Prostaglandins I; Real-Time Polymerase Chain Reaction; Receptors, Epoprostenol; Receptors, G-Protein-Coupled; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles; Xanthones

2015
PGE2 released by primary sensory neurons modulates Toll-like receptor 4 activities through an EP4 receptor-dependent process.
    Journal of neuroimmunology, 2016, Apr-15, Volume: 293

    Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP4 Subtype; Sensory Receptor Cells; Sulfonamides; Thiophenes; Toll-Like Receptor 4; Triazoles; Tumor Necrosis Factor-alpha

2016
The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2017, Volume: 46, Issue:10

    Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Proliferation; Dinoprostone; Humans; Mouth Neoplasms; Receptors, Prostaglandin E, EP4 Subtype; Thiophenes; Triazoles; Tumor Cells, Cultured

2017
L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels.
    BMC musculoskeletal disorders, 2017, Nov-16, Volume: 18, Issue:1

    Topics: Animals; Ankle Joint; Arthritis, Experimental; Arthritis, Rheumatoid; Celecoxib; Cell Differentiation; Cell Proliferation; Chemokine CCL2; Collagen Type II; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Female; Humans; Injections, Intraperitoneal; Interleukin-17; Mice; Mice, Inbred DBA; Receptors, Prostaglandin E, EP4 Subtype; Severity of Illness Index; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Thiophenes; Triazoles

2017
Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat.
    Neuroscience, 2018, 12-01, Volume: 394

    Topics: Analgesics, Opioid; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Intradermal; Male; Nociception; Pain Threshold; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds; Thiophenes; Urea

2018
Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis.
    Nature communications, 2019, 01-14, Volume: 10, Issue:1

    Topics: Adrenergic beta-Antagonists; Adrenergic Fibers; Animals; Bone and Bones; Bone Density; Bone Regeneration; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Feedback, Physiological; Female; Humans; Hydroxyprostaglandin Dehydrogenases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoblasts; Osteoporosis; Propranolol; Pyridines; Receptors, Prostaglandin E, EP4 Subtype; Sensory Receptor Cells; Thiophenes

2019
Inhibiting eicosanoid degradation exerts antifibrotic effects in a pulmonary fibrosis mouse model and human tissue.
    The Journal of allergy and clinical immunology, 2020, Volume: 145, Issue:3

    Topics: Animals; Apoptosis; Cell Proliferation; Dinoprostone; Eicosanoids; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hydroxyprostaglandin Dehydrogenases; Idiopathic Pulmonary Fibrosis; Mice; MicroRNAs; Pyridines; Thiophenes

2020
Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis.
    Scientific reports, 2020, 07-15, Volume: 10, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Bleomycin; Body Weight; Dinoprostone; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Extracellular Matrix; Female; Gene Expression; Humans; Hydroxyprostaglandin Dehydrogenases; Idiopathic Pulmonary Fibrosis; Inflammation; Lung; Macrophages; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Pyridines; Respiratory Function Tests; Survival Analysis; Thiophenes

2020
Synthesis and Anti-Inflammatory Activity of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-Derived NRF2 Activators.
    ChemistryOpen, 2022, Volume: 11, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cytokines; Dinoprostone; Humans; Inflammation Mediators; Interleukin-6; Kelch-Like ECH-Associated Protein 1; Lipopolysaccharides; Mice; NF-E2-Related Factor 2; NF-kappa B; Rats; RNA, Messenger; Thiophenes; Tumor Necrosis Factor-alpha

2022