Compounds > thiophenes
Page last updated: 2024-08-18

thiophenes and cyclopamine

thiophenes has been researched along with cyclopamine in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (14.29)29.6817
2010's9 (64.29)24.3611
2020's3 (21.43)2.80

Authors

AuthorsStudies
Barak, LS; Beachy, PA; Chen, JK; Chen, W; de Sauvage, F; Lefkowitz, RJ; Nelson, CD; Ren, XR1
Bee, WL; Copeland, RA; Davenport, EA; Gilmartin, A; Gontarek, R; Hornberger, KR; Kallal, LA; Lai, Z; Lawrie, K; Lu, Q; McMillan, L; Rominger, CM; Rominger, DH; Truong, M; Tummino, PJ; Turunen, B; Will, M; Zuercher, WJ1
Peng, LF; Stanton, BZ1
Bartesaghi, R; Ciani, E; Fuchs, C; Guidi, S; Mitrugno, VM; Perini, G; Rizzi, S; Trazzi, S; Valli, E1
Krieg, PA; Moran, CM; Salanga, MC1
Aberger, F; Bender, C; Berg, D; Eberl, M; Friedel, M; Frischauf, A; Götschel, F; Gruber, W; Hache, H; Korf, U; Lehrach, H; Nietfeld, W; Rüngeler, E; Schwartz-Albiez, R; Sonntag, J; Wierling, C1
Krieg, PA; Lewis, C1
Chen, X; Fan, Y; Hao, W; Hou, X; Jin, Y; Liu, F; Ma, A; Pang, T; Song, Z; Wang, W; Wang, Y; Zhang, P1
Chung, UI; Hojo, H; Kanke, K; Komiyama, Y; Lichtler, AC; Masaki, H; Nakauchi, H; Ohba, S; Saito, T; Takato, T1
Liu, Q; Liu, X; Wang, M; Xu, Q; Yao, Y; Zheng, X1
Lozito, TP; Tuan, RS1
Haraguchi, R; Imai, Y; Kitazawa, R; Kitazawa, S; Kohara, Y1
Chang, Y; Chen, S; Guo, Y; Sun, Y; Xu, J; You, S; Zhang, N; Zhang, Y1
Bhattacharyya, S; De, R; Kaur, H; Pal, A; Sharma, A; Srinivasan, R1

Reviews

1 review(s) available for thiophenes and cyclopamine

ArticleYear
Small-molecule modulators of the Sonic Hedgehog signaling pathway.
    Molecular bioSystems, 2010, Volume: 6, Issue:1

    Topics: Anilides; Animals; Dioxoles; Hedgehog Proteins; Humans; Models, Biological; Molecular Structure; Piperazines; Pyrazoles; Pyridines; Receptors, G-Protein-Coupled; Signal Transduction; Smoothened Receptor; Thiophenes; Veratrum Alkaloids

2010

Other Studies

13 other study(ies) available for thiophenes and cyclopamine

ArticleYear
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
    Science (New York, N.Y.), 2004, Dec-24, Volume: 306, Issue:5705

    Topics: Arrestins; beta-Adrenergic Receptor Kinases; beta-Arrestin 2; beta-Arrestins; Cell Line; Cell Membrane; Clathrin; Coated Pits, Cell-Membrane; Cyclic AMP-Dependent Protein Kinases; Cyclohexylamines; Cytosol; Dynamins; Endocytosis; Hedgehog Proteins; Humans; Membrane Proteins; Patched Receptors; Phosphorylation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Signal Transduction; Smoothened Receptor; Thiophenes; Trans-Activators; Transfection; Veratrum Alkaloids

2004
Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3

    Topics: Anilides; Animals; Benzamides; Benzimidazoles; beta-Lactamases; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cyclohexylamines; Genes, Reporter; Humans; Kinetics; Mice; Molecular Structure; Morpholines; NIH 3T3 Cells; Piperazines; Purines; Pyrazoles; Pyridines; Radioligand Assay; Receptors, G-Protein-Coupled; Recombinant Proteins; Smoothened Receptor; Thiophenes; Tomatine; Transfection; Veratrum Alkaloids

2009
APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.
    Human molecular genetics, 2011, Apr-15, Volume: 20, Issue:8

    Topics: Acetylation; Amyloid beta-Protein Precursor; Animals; Cell Cycle; Cell Proliferation; Cyclohexylamines; DNA Methylation; Down Syndrome; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Hedgehog Proteins; Hippocampus; Humans; Kruppel-Like Transcription Factors; Lateral Ventricles; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Nuclear Proteins; Patched Receptors; Patched-1 Receptor; Polycomb Repressive Complex 1; Promoter Regions, Genetic; Protein Structure, Tertiary; Proto-Oncogene Proteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Repressor Proteins; RNA Interference; Smoothened Receptor; Thiophenes; Up-Regulation; Veratrum Alkaloids; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2; Zinc Finger Protein Gli3

2011
Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development.
    Developmental dynamics : an official publication of the American Association of Anatomists, 2011, Volume: 240, Issue:6

    Topics: Animals; Aorta; Birds; Blood Vessels; Cell Count; Chick Embryo; Cyclohexylamines; Endothelium, Vascular; Gene Expression Regulation, Developmental; Hedgehog Proteins; Organ Size; Signal Transduction; Teratogens; Thiophenes; Veratrum Alkaloids

2011
Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Biomarkers, Tumor; Blotting, Western; Carrier Proteins; Cell Proliferation; Cells, Cultured; Cerebellar Neoplasms; Cyclohexylamines; Dermis; Drug Synergism; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Fibroblasts; Gene Expression Profiling; Hedgehog Proteins; HEK293 Cells; Humans; Interleukin-8; Matrix Metalloproteinase 7; Medulloblastoma; Membrane Glycoproteins; Oligonucleotide Array Sequence Analysis; Patched Receptors; Patched-1 Receptor; Phosphorylation; Protein Array Analysis; Real-Time Polymerase Chain Reaction; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes; Transcription Factors; Vascular Endothelial Growth Factor A; Veratrum Alkaloids; Zinc Finger Protein GLI1

2013
Reagents for developmental regulation of Hedgehog signaling.
    Methods (San Diego, Calif.), 2014, Apr-01, Volume: 66, Issue:3

    Topics: Animals; Cyclohexylamines; Embryo Culture Techniques; Embryonic Development; Gene Expression Regulation, Developmental; Hedgehog Proteins; Morpholines; Purines; Signal Transduction; Thiophenes; Veratrum Alkaloids; Xenopus

2014
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells.
    Biochimie, 2014, Volume: 101

    Topics: Antineoplastic Agents; Apoptosis; Drug Screening Assays, Antitumor; Drug Synergism; Hedgehog Proteins; Humans; Jurkat Cells; MAP Kinase Signaling System; Oxadiazoles; Phosphorylcholine; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Pyridines; Thiophenes; Transcription Factors; Veratrum Alkaloids; Zinc Finger Protein GLI1

2014
Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions.
    Stem cell reports, 2014, Jun-03, Volume: 2, Issue:6

    Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Cyclohexylamines; Humans; Mice; Osteoblasts; Pluripotent Stem Cells; Pyridines; Pyrimidines; Thiophenes; Veratrum Alkaloids

2014
The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma.
    International journal of molecular medicine, 2014, Volume: 34, Issue:3

    Topics: Adenylate Kinase; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclohexylamines; Female; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Hep G2 Cells; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Prognosis; Proportional Hazards Models; Protein Binding; RNA, Messenger; Thiophenes; Transcription Factors; Transcription, Genetic; Veratrum Alkaloids; Zinc Finger Protein GLI1

2014
Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration.
    Development (Cambridge, England), 2016, 08-15, Volume: 143, Issue:16

    Topics: Animals; Bone Morphogenetic Proteins; Cartilage; Cyclohexylamines; Fracture Healing; Growth Plate; Hedgehog Proteins; Lizards; Regeneration; Signal Transduction; Tail; Thiophenes; Veratrum Alkaloids

2016
Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of
    International journal of molecular sciences, 2020, Apr-15, Volume: 21, Issue:8

    Topics: Aging; Animals; Cell Survival; Cells, Cultured; Gene Expression Regulation, Developmental; Hedgehog Proteins; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoclasts; Osteogenesis; Osteoporosis; Pyridines; Pyrimidines; Receptor, Macrophage Colony-Stimulating Factor; Signal Transduction; Smoothened Receptor; Thiophenes; Up-Regulation; Veratrum Alkaloids; X-Ray Microtomography; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2

2020
Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog.
    Life sciences, 2020, Sep-15, Volume: 257

    Topics: Animals; Atherosclerosis; Becaplermin; Cell Movement; Cell Proliferation; Cyclohexylamines; Gene Knockdown Techniques; Hedgehog Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle; PAX9 Transcription Factor; Phenotype; Signal Transduction; Thiophenes; Veratrum Alkaloids

2020
Knockdown of E-cadherin induces cancer stem-cell-like phenotype and drug resistance in cervical cancer cells.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 2021, Volume: 99, Issue:5

    Topics: Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Female; Humans; Neoplastic Stem Cells; Phenotype; Pyridines; RNA, Small Interfering; Thiophenes; Uterine Cervical Neoplasms; Veratrum Alkaloids

2021