thiophenes has been researched along with carbostyril in 200 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (4.50) | 18.2507 |
| 2000's | 16 (8.00) | 29.6817 |
| 2010's | 108 (54.00) | 24.3611 |
| 2020's | 67 (33.50) | 2.80 |
| Authors | Studies |
|---|---|
| Asin, KE; Britton, DR; DiDomenico, S; Hong, Y; Lin, CW; Michaelides, MR; Shiosaki, K; Williams, M | 1 |
| Asin, KE; Bianchi, B; Britton, DR; Didomenico, S; Hodges, L; Hong, Y; Jenner, P; Lin, CW; Mahan, L; Michaelides, M; Mikusa, J; Miller, T; Nikkel, A; Shiosaki, K; Smith, L; Stashko, M; Williams, M; Witte, D | 1 |
| Asin, KE; Bednarz, L; Britton, DR; Giardina, WJ; Mahan, L; Mikusa, J; Nikkel, A; Shiosaki, K; Wismer, C | 1 |
| Asin, KE; Domino, EF; Nikkel, A; Shiosaki, K | 1 |
| Asin, KE; Bayburt, EK; Britton, DR; DiDomenico, S; Hong, Y; Lin, CW; Michaelides, MR; Shiosaki, K | 1 |
| Bédard, PJ; Britton, DR; Grondin, R; Shiosaki, K | 1 |
| Conti, M; Hanssen, RG; Hirsch, B; Hsueh, AJ; Kloosterboer, HJ; Tsafriri, A; Van de Kant, M; Wiersma, A | 1 |
| Britton, DR; Jackson, M; Jenner, P; Marsden, CD; Pearce, RK; Shiosaki, K | 1 |
| Adjei, AL; Bertz, RJ; El-Shourbagy, T; Marsh, KC; Zheng, Y | 1 |
| Jackson, M; Jenner, P; Treseder, SA | 1 |
| Nelson, SD | 1 |
| Conti, M; DePaolo, LV; Jensen, JT; Schwinof, KM; Stouffer, RL; Zelinski-Wooten, MB | 1 |
| Foroumadi, A; Mirzaei, M; Soltani, F | 1 |
| Dogan Koruznjak, J; Grdisa, M; Karminski-Zamola, G; Pavelić, K; Slade, N; Zamola, B | 1 |
| Tomioka, K; Yamada, K; Yamashita, M | 1 |
| Dogan, J; Jarak, I; Karminski-Zamola, G; Kralj, M; Pavelić, K; Pavlović, G; Piantanida, I; Suman, L; Zinić, M | 1 |
| Cortvrindt, R; Everaerdt, B; Nogueira, D; Smitz, J | 1 |
| Jarak, I; Karminski-Zamola, G; Kralj, M; Pavelić, K; Piantanida, I; Suman, L; Zinić, M | 1 |
| Emami, S; Foroumadi, A; Karimollah, A; Moshafi, MH; Oboudiat, M; Saghaee, L; Shafiee, A | 1 |
| Bouhours, P; Broussous, S; David, E; Fournier Dit Chabert, J; Joucla, L; Lemaire, M; Marquet, B; Marquez, B; Moreau, N; Neville, L; Pellet-Rostaing, S | 1 |
| Bartlett, JB; Berg, S; Carey, F; Charles, AD; Convey, G; De Schoolmeester, J; Freeman, S; Loxham, SJ; Poucher, SM; Teague, J; Turnbull, AV; Walker, M | 1 |
| Karminski-Zamola, G; Koruznjak, JD; Safarik, JB | 1 |
| Bag, S; Degani, MS; Tawari, NR | 1 |
| Apfeldorf, WJ; Cullen, CE; Eide, CE; Lu, BY; Williams, CC | 1 |
| Butters, MA; Dew, MA; Driscoll, HC; Lenze, EJ; Miller, MD; Mulsant, BH; Pollock, BG; Reynolds, CF; Sheffrin, M | 1 |
| Aleksić, M; Bertosa, B; Karminiski-Zamola, G; Tomić, S | 1 |
| Aung, GL; Kawamoto, LS; O'Brien, JG; Tien, PG | 1 |
| Enoksen, TB; Hendset, M; Hermann, M; Molden, E; Refsum, H | 1 |
| Bailey, C; Barbeau, OR; Cano, C; Cockcroft, XL; Curtin, NJ; Duggan, H; Frigerio, M; Golding, BT; Griffin, RJ; Hardcastle, IR; Hummersone, MG; Knights, C; Menear, KA; Newell, DR; Richardson, CJ; Smith, GC; Spittle, B | 1 |
| Chang, CH; Chen, SJ; Chen, ST; Hsiao, YL; Shen, TW | 1 |
| Bar, S; Hajra, S | 1 |
| Aleksić, M; Bertoša, B; David-Cordonnier, MH; Depauw, S; Jarak, I; Karminski-Zamola, G; Kralj, M; Nhili, R; Tomić, S; Uzelac, L | 1 |
| Chambon, C; Danysz, W; Gravius, A; Jatzke, C; Wegener, N | 1 |
| Pitchot, W | 1 |
| Chatterjee, A; Cutler, SJ; Khan, IA; Williamson, JS | 1 |
| Inamoto, K | 1 |
| Aleksić, M; Bertoša, B; David-Cordonnier, MH; Depauw, S; Karminski-Zamola, G; Kralj, M; Martin-Kleiner, I; Nhili, R; Tomić, S | 1 |
| Jiao, P; Liu, H; Xue, W; Yao, X | 1 |
| Begley, A; Butters, MA; Koenig, AM; Ogbagaber, S; Reynolds, CF; Wahed, AS | 1 |
| Akazawa, H; Amada, N; Arnt, J; Bundgaard, C; Futamura, T; Hentzer, M; Ito, N; Kikuchi, T; Maeda, K; McQuade, RD; Mørk, A; Nielsen, V; Pehrson, AL; Shimada, J; Stensbøl, TB; Sugino, H; Yamashita, H | 1 |
| Fujita, Y; Futamura, T; Hashimoto, K; Kikuchi, T; Ohgi, Y; Yoshimi, N | 1 |
| Blier, P; El Mansari, M; Oosterhof, CA | 1 |
| Futamura, T; Hashimoto, K; Yoshimi, N | 1 |
| Carson, WH; Eriksson, H; Hobart, M; Kane, JM; McQuade, RD; Nyilas, M; Ouyang, J; Pfister, S; Sanchez, R; Skuban, A | 1 |
| Futamura, T; Hashimoto, K; Ishima, T; Kikuchi, T; Ohgi, Y; Yoshimi, N | 1 |
| Howland, RH | 1 |
| Carson, WH; Correll, CU; Eriksson, H; Hobart, M; McQuade, RD; Nyilas, M; Ouyang, J; Pfister, S; Sanchez, R; Skuban, A | 1 |
| Citrome, L | 4 |
| Kibble, A | 1 |
| Augustine, C; Carson, WH; Eriksson, H; Hobart, M; McQuade, RD; Nyilas, M; Sanchez, R; Skuban, A; Thase, ME; Youakim, JM; Zhang, P | 1 |
| Carson, WH; Eriksson, H; Hobart, M; McQuade, RD; Nyilas, M; Sanchez, R; Skuban, A; Thase, ME; Youakim, JM; Zhang, P | 1 |
| Greig, SL | 1 |
| Goff, DC | 1 |
| Citrome, L; Maeda, K; Stensbøl, TB | 1 |
| Blier, P; Bundgaard, C; El Mansari, M; Oosterhof, CA | 1 |
| Yee, A | 1 |
| Citrome, L; McEvoy, J | 1 |
| McKeage, K | 1 |
| Stahl, SM | 1 |
| Baker, RA; Citrome, L; Nagamizu, K; Ota, A; Perry, P; Weiller, E | 1 |
| Garnock-Jones, KP | 1 |
| Blankenfeldt, W; Drees, SL; Empting, M; Fetzner, S; Hartmann, RW; Maurer, CK; Weidel, E; Witzgall, F; Zender, M | 1 |
| Correll, CU; Hobart, M; Kane, JM; Ouyang, J; Skuban, A; Weiller, E; Weiss, C | 2 |
| McIntyre, RS; Weiller, E; Weiss, C; Zhang, P | 1 |
| Hussar, DA | 1 |
| Bruijnzeel, D; Tandon, R | 1 |
| Baker, RA; Ota, A; Perry, P; Sheehan, DV; Tsuneyoshi, K; Weiller, E; Weisler, RH | 1 |
| Fujiwara, K; Hasegawa, K; Ikeda, Y; Imai, Y; Iwasa, A; Kato, T; Miyamoto, T; Nakamura, Y; Okabe, S; Park, JH; Takamatsu, N | 1 |
| Baker, RA; Davidsen, CK; Fava, M; Ménard, F | 1 |
| Carson, WH; Fleischhacker, WW; Forbes, A; Hobart, M; McQuade, RD; Nyilas, M; Ouyang, J; Pfister, S; Sanchez, R; Weiller, E | 1 |
| Baker, RA; Malla, A; Nagamizu, K; Ota, A; Perry, P; Weiller, E | 1 |
| Aigbogun, MS; Duffy, R; Hartry, A; Kamat, SA; Legacy, S; Sussman, M; Yu, J | 1 |
| Oberoi, AS; Philip, L | 1 |
| Baker, RA; Davis, LL; Ota, A; Perry, P; Tsuneyoshi, K; Weiller, E | 1 |
| Baker, RA; Fava, M; Matsushima, Y; Okame, T; Perry, P; Weiller, E | 1 |
| Beyer, JL; Weisler, RH | 1 |
| Baker, RA; Krystal, AD; Meisels, P; Mittoux, A | 1 |
| Dong, C; Futamura, T; Hashimoto, K; Ma, M; Ohgi, Y; Ren, Q; Yang, C; Yao, W; Zhang, JC | 2 |
| Hakala, MJ; Hobart, M; Josiassen, MK; Marder, SR; Ouyang, J; Weiller, E; Weiss, C; Zhang, P | 1 |
| Han, C; Jeon, SW; Ko, YH; Masand, PS; Pae, CU; Patkar, AA; Yoon, S | 1 |
| Hsu, WY; Lane, HY; Lin, CH | 1 |
| Inoue, H; Kato, T; Matsuo, Y; Miyamoto, T; Nakamura, Y; Park, JH; Salgia, R; Zewde, M | 1 |
| Arnt, J; Geyer, MA; Milienne-Petiot, M; Young, JW | 1 |
| Björkholm, C; Jardemark, K; Konradsson-Geuken, Å; Marcus, MM; Svensson, TH | 1 |
| Fava, M; Weiller, E; Weiss, C; Zhang, P | 1 |
| Gallipani, A; Markovic, M; Maroney, M; Patel, KH | 1 |
| Abate, C; Capparelli, E; Colabufo, NA; Contino, M; Spinelli, F | 1 |
| Aftab, A; Gao, K | 1 |
| Dong, C; Fujita, Y; Futamura, T; Hashimoto, K; Ma, M; Ohgi, Y; Ren, Q; Yang, C | 1 |
| Higashi, K; Ishigooka, J; Iwashita, S; Liew, EL; Tadori, Y | 1 |
| Ekinci, A; Ekinci, O | 1 |
| Castle, D; Hope, J; Keks, NA | 1 |
| Hobart, M; Nelson, JC; Weiller, E; Weiss, C; Zhang, P | 1 |
| Augustine, C; Carroll, K; Hobart, M; Koch, G; Zhang, P | 1 |
| Cope, ZA; Geyer, MA; Hellemann, G; Kwiatkowski, MA; Minassian, A; Perry, W; Sugar, CA; Young, JW | 1 |
| Augustine, C; Brewer, C; Hefting, N; Hobart, M; Josiassen, MK; McQuade, RD; Sanchez, R; Skuban, A; Zhang, P | 1 |
| Forbes, A; Hakala, M; Hobart, M; Ouyang, J; Pfister, S; Shi, L | 1 |
| Aladeen, T; Capote, H; Lee, Y; McIntyre, RS; Rainka, M; Rong, C; Westphal, E | 1 |
| Ishigooka, J; Iwashita, S; Tadori, Y | 2 |
| Liu, W; Wei, P; Yan, R; Zou, Q | 1 |
| Burudpakdee, C; Greene, M; Hartry, A; Seetasith, A | 1 |
| Augustine, C; Brewer, C; Hefting, N; Hobart, M; McQuade, RD; Sanchez, R; Skuban, A; Zhang, P | 1 |
| Baker, RA; Duffy, RA; Gwin, KK; McQuade, RD; Weiller, E; Weiss, C; Zhang, P | 1 |
| Eriksson, H; Newcomer, JW; Weiller, E; Weiss, C; Zhang, P | 1 |
| Hefting, N; Hobart, M; Lepola, U; Zhang, D | 1 |
| Bauer, M; Hefting, N; Hobart, M; Josiassen, MK; Lindsten, A | 1 |
| Serretti, A | 1 |
| Baker, RA; Correll, CU; Duffy, RA; Eramo, A; Hobart, M; Shi, L; Weiller, E; Weiss, C | 1 |
| Ashton, TM; Herbert, KJ; Higgins, GS; Pirovano, G; Prevo, R | 1 |
| Eriksson, H; Hobart, M; Meehan, SR; Weiss, C; Zhang, P | 1 |
| Broder, MS; Chang, E; Greene, M; Hartry, A; Yan, T; Yermilov, I | 1 |
| Frampton, JE | 1 |
| Limandri, BJ | 1 |
| Brown, ES; Escalante, C; Holmes, T; Ivleva, E; Khaleghi, N; Mason, BL; Nakamura, A; Van Enkevort, E | 1 |
| Fukuda, T; Kasama, T; Miura, O; Suwa, S; Uchida, E; Watanabe, K; Yoshimoto, R | 1 |
| Kate, AS; Thakkar, D | 2 |
| Guo, Y; Li, BY; Na, S; Steele, HE | 1 |
| Citrome, LL; Manning, JS; McIntosh, D; McIntyre, RS | 1 |
| Chhalotiya, UK; Desai, JV; Parekh, N; Shah, DA; Thakkar, AM | 1 |
| Bitter, I; Corponi, F; Fabbri, C; Kasper, S; Montgomery, S; Pallanti, S; Serretti, A; Vieta, E | 1 |
| Iwata, N; Kishi, T; Matsuda, Y; Mishima, K; Nomura, I; Sakuma, K | 1 |
| Davis, JM | 1 |
| Kitanaka, C; Okada, M; Sanomachi, T; Seino, S; Suzuki, S; Togashi, K; Yamamoto, M; Yoshioka, T | 1 |
| Cai, JP; Chen, B; Chen, D; Hu, GX; Wang, S; Wen, J; Zhang, B; Zhang, XD | 1 |
| Eriksson, H; Meehan, SR; Newcomer, JW; Weiss, C; Zhang, P | 1 |
| Kumakura, J; Okada, T; Suda, S; Yasuda, M | 1 |
| Jakubowiak, AJ; Johnson, D; Nakamura, Y; Park, JH; Rosebeck, S; Stefka, AT | 1 |
| Futamura, T; Kikuchi, T; Maeda, K; Niidome, K; Suzuki, M; Usami, T | 1 |
| Aoki, S; Shimizu, H; Takeda, T; Washida, K; Yamashita, R; Yoshimura, Y | 1 |
| Chou, KL; Jackowiak, EM | 1 |
| Cummings, OT; Enders, JR; Feng, S; McIntire, G; McIntire, T; Strickland, EC | 1 |
| Almeida, OP; Ford, AH | 1 |
| Carroll, KJ; Koch, G; Lee, J; Ouyang, J; Zhang, P | 1 |
| Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S | 1 |
| O'Connor, M | 1 |
| Broder, MS; Chang, E; Greene, M; Houle, CR; Tarbox, MH; Waters, HC; Yan, T | 1 |
| Funayama, M; Mimura, M; Mimura, Y; Oi, H; Takata, T; Takeuchi, H | 1 |
| Ikuta, T; Iwata, N; Kishi, T; Matsuda, Y; Sakuma, K | 1 |
| Antoun Reyad, A; Girgis, E; Mishriky, R | 1 |
| Moss, MJ; Rodriguez, SA | 1 |
| Copolov, D; Hope, J; Keks, N; McLennan, H; Meadows, G; Schwartz, D | 1 |
| Ishigooka, J; Iwashita, S; Kojima, Y; Matsuo, S; Usami, T | 1 |
| Bell, E; Hamilton, A; Malhi, GS; Morris, G | 1 |
| Baker, RA; Cox, K; Eramo, A; Kojima, Y; Okame, T; Potkin, SG; van Erp, TG | 1 |
| Hamuro, A; Wakaura, Y | 1 |
| Markovic, M; Maroney, M; Stummer, L | 1 |
| Ismail, Z; Meade, N; Meehan, SR; Shi, L; Weiss, C | 1 |
| Cannavò, D; Caraci, F; Caruso, G; Drago, F; Leggio, GM; Salomone, S; Santagati, M | 1 |
| Arnt, J; Desmedt, A; Ducourneau, EG; Guette, C; Mombereau, C; Mondesir, M; Perrot, D; Piazza, PV | 1 |
| Boku, S; Fujiyama, H; Fukuhara, R; Kanno, T; Kawahara, K; Sugawara, H; Takebayashi, M; Tanaka, H | 1 |
| Lafrenière, S; Légaré, N; Picotte, F | 1 |
| Dean, DC; Duan, Z; Hornicek, FJ; Nelson, SD; Thanindratarn, P | 1 |
| Baker, RA; Krystal, AD; Lindsten, A; Mittoux, A | 1 |
| Alhawas, L; Amin, KS; Banerjee, PP; Salla, B | 1 |
| Kwon, M; Lee, DW; Lee, HN; Lee, W | 1 |
| Nadella, PN; Nadh Ratnakaram, V; Navuluri, S | 1 |
| Espay, AJ; Gupta, HV; Sharma, VD | 1 |
| Kikuchi, T; Otsubo, T; Watanabe, Y; Yamada, S | 1 |
| Aoki, K; Inada, K; Ishigooka, J; Iwashita, S; Kojima, Y; Niidome, K; Yamada, S | 1 |
| Baas, CAJ; Knegtering, H; Spoelstra, SK | 1 |
| Hosokawa, Y; Inaguma, S; Inoue, S; Kasai, K; Kasugai, K; Kato, H; Komura, M; Koshino, A; Nagano-Matsuo, A; Nagayasu, Y; Naiki-Ito, A; Nakao, K; Ota, A; Takahashi, S; Takiguchi, S; Watanabe, K | 1 |
| Brewer, C; Chang, D; Hefting, N; Hellsten, J; Peters-Strickland, T; Sachs, G; Vieta, E | 1 |
| Hibino, H; Inoue, Y; Matsumoto, H; Mikami, K; Suzuki, H; Takaya, A; Yamamoto, K | 2 |
| Alefishat, E; Aloum, L; Baltatu, OC; Petroianu, GA | 1 |
| Futamura, T; Hirose, T; Kikuchi, T; Maeda, K; McQuade, RD; Suzuki, M | 1 |
| Che, KK; Hu, CH; Li, DJ; Liu, L; Liu, XM; Yue, Q | 1 |
| Deng, L; He, Y; Wu, B; Wu, L; Yin, Z | 1 |
| Fukuyama, K; Okada, M | 1 |
| Aguirre, C; Garcia, M; Lertxundi, U; Morera-Herreras, T; Zazu, L | 1 |
| Edinoff, AN; Girma, B; Kaye, AD; Kaye, AJ; Kaye, AM; Kaye, JS; Leethy, KN; Maxey, BS; Mychaskiw, G; Odisho, A; Ren, AL; Urits, I; Viswanath, O; Wu, NW | 1 |
| Kate, AS; Rathod, R; Sahu, AK; Sengupta, P; Thakkar, D | 1 |
| Chang, HA; Chiao, HY; Huang, YC; Kung, FH; Lin, HY; Tai, YM; Tzeng, NS | 1 |
| Bruno, CD; Chow, CR; Elmokadem, A; Greenblatt, DJ; Housand, C; Jordie, EB; Lesko, LJ | 1 |
| Fišar, Z; Hroudová, J; Ľupták, M | 1 |
| Fernando, R; Gan, L; Xiao, J; Yun, Y | 1 |
| Schooler, NR | 1 |
| Manu, P | 1 |
| Bellagamba, S; Orsolini, L; Salvi, V; Volpe, U | 1 |
| De Ponti, F; Fusaroli, M; Giunchi, V; Menchetti, M; Poluzzi, E; Raschi, E; Rimondini Giorgini, R | 1 |
| Ghiviriga, I; Horenstein, N; Li, H; Mirabel, R; Phidd, DK; Urs, NM; Zimmerman, J | 1 |
| Furukawa, Y; Hamza, T; Kasai, K; Obata, S; Oguro, S; Ostinelli, EG | 1 |
| Fukuyama, K; Motomura, E; Okada, M | 1 |
| Amendola, C; Beccarini Crescenzi, B; Casolaro, I; Crapanzano, C | 1 |
| De Ronchi, D; Fabbri, C; Fanelli, G; Lippi, M; Serretti, A | 1 |
| Hishimoto, A; Matsukawa, M; Sekine, D; Yamada, S; Yasui-Furukori, N | 1 |
| Boucher, M; de Jong-Laird, A; Katzman, MA; MacKenzie, EM; Therrien, F; Wang, F | 1 |
| Carpenter, JS; Crouse, JJ; Garland, A; Hickie, IB; Koethe, D; Leweke, FM; McHugh, C; Nichles, A; Rohleder, C; Scott, EM; Song, YJC; Wilson, C; Zmicerevska, N | 1 |
| Cahill, D; Kohegyi, E; Larsen, F; Raoufinia, A; Wang, X; Wang, Y; Ward, C; Zoubroulis, A | 1 |
| Cheng, CS; Kuo, CJ; Lin, SK | 1 |
| Devanand, DP | 1 |
42 review(s) available for thiophenes and carbostyril
| Article | Year |
|---|---|
Structure toxicity relationships--how useful are they in predicting toxicities of new drugs?
Topics: Analgesics; Androgen Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Chromans; Drug-Related Side Effects and Adverse Reactions; Flutamide; Humans; Hypoglycemic Agents; Indoles; Molecular Structure; Oxindoles; Pharmaceutical Preparations; Quinolones; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Thiophenes; Troglitazone | 2001 |
Synthesis of heterocyclic compounds through palladium-catalyzed C-H cyclization processes.
Topics: Benzothiazoles; Carbon; Catalysis; Cyclization; Heterocyclic Compounds; Hydrogen; Indazoles; Indoles; Palladium; Quinolones; Thiophenes | 2013 |
Brexpiprazole for schizophrenia and as adjunct for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antipsychotic - what is the number needed to treat, number needed to harm and likelihood to be hel
Topics: Antidepressive Agents; Antipsychotic Agents; Chemotherapy, Adjuvant; Clinical Trials as Topic; Depressive Disorder, Major; Dopamine Agonists; Humans; Quinolones; Schizophrenia; Thiophenes | 2015 |
Brexpiprazole: a new dopamine D₂receptor partial agonist for the treatment of schizophrenia and major depressive disorder.
Topics: Depressive Disorder, Major; Dopamine Agonists; Humans; Quinolones; Receptors, Dopamine D2; Schizophrenia; Thiophenes | 2015 |
Brexpiprazole (Rexulti) for schizophrenia and depression.
Topics: Animals; Depressive Disorder, Major; Dopamine Agonists; Humans; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Serotonin Agents; Thiophenes | 2015 |
Brexpiprazole: First Global Approval.
Topics: Depressive Disorder; Drug Approval; Humans; Internationality; Molecular Structure; Quinolones; Schizophrenia; Thiophenes | 2015 |
The preclinical profile of brexpiprazole: what is its clinical relevance for the treatment of psychiatric disorders?
Topics: Animals; Clinical Trials, Phase III as Topic; Drug Evaluation, Preclinical; Humans; Mental Disorders; Quinolones; Randomized Controlled Trials as Topic; Thiophenes | 2015 |
Brexpiprazole for the treatment of schizophrenia.
Topics: Antipsychotic Agents; Dopamine Agonists; Humans; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes; Treatment Outcome | 2016 |
Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator.
Topics: Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes | 2016 |
Adjunctive Brexpiprazole: A Review in Major Depressive Disorder.
Topics: Antidepressive Agents; Clinical Trials, Phase III as Topic; Depressive Disorder, Major; Drug Therapy, Combination; Humans; Quinolones; Thiophenes | 2016 |
Brexpiprazole: A Review in Schizophrenia.
Topics: Animals; Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes | 2016 |
Efficacy of brexpiprazole in patients with acute schizophrenia: Review of three randomized, double-blind, placebo-controlled studies.
Topics: Acute Disease; Antipsychotic Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes | 2016 |
Overview of short- and long-term tolerability and safety of brexpiprazole in patients with schizophrenia.
Topics: Antipsychotic Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes | 2016 |
Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression.
Topics: Animals; Depressive Disorder, Major; Humans; Quinolones; Schizophrenia; Thiophenes | 2016 |
Adjunctive Brexpiprazole as a Novel Effective Strategy for Treating Major Depressive Disorder: A Systematic Review and Meta-Analysis.
Topics: Depressive Disorder, Major; Humans; Quinolones; Serotonin Agents; Thiophenes | 2017 |
Brexpiprazole for the treatment of schizophrenia.
Topics: Antipsychotic Agents; Cognition; Dopamine; Humans; Psychomotor Agitation; Quinolones; Receptors, Dopamine D2; Schizophrenia; Serotonin; Thiophenes | 2017 |
Emerging pharmacological therapies in schizophrenia: what's new, what's different, what's next?
Topics: Antipsychotic Agents; Aripiprazole; Delayed-Action Preparations; Humans; Injections, Intramuscular; Paliperidone Palmitate; Piperazines; Quinolones; Schizophrenia; Tetrabenazine; Thiophenes; Valine | 2016 |
Brexpiprazole.
Topics: Antidepressive Agents; Antipsychotic Agents; Clinical Trials, Phase III as Topic; Depressive Disorder, Major; Drug Therapy, Combination; Humans; Quinolones; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Schizophrenia; Thiophenes; Weight Gain | 2017 |
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure-Affinity Relationship (SAfiR) and Structure-Activity Relationship (SAR) Studies.
Topics: Humans; Indoles; Ligands; Molecular Docking Simulation; Neurodegenerative Diseases; Neuroprotective Agents; Positron-Emission Tomography; Purines; Quinolones; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Thiophenes | 2017 |
The preclinical discovery and development of brexpiprazole for the treatment of major depressive disorder.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Depressive Disorder, Major; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Quinolones; Thiophenes | 2017 |
Brexpiprazole: A Partial Dopamine Agonist for the Treatment of Schizophrenia.
Topics: Dopamine Agonists; Humans; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome | 2018 |
Brexpiprazole: a new leaf on the partial dopamine agonist branch.
Topics: Antipsychotic Agents; Aripiprazole; Depressive Disorder, Treatment-Resistant; Dopamine Agonists; Humans; Quinolones; Schizophrenia; Thiophenes | 2018 |
Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors.
Topics: alpha-Methyltyrosine; Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Cohort Studies; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Exploratory Behavior; Gene Knockdown Techniques; Locomotion; Mice; Mice, Inbred C57BL; Quinolones; Reproducibility of Results; Thiophenes; Tyrosine 3-Monooxygenase; Valproic Acid | 2019 |
Changes in metabolic parameters and body weight in brexpiprazole-treated patients with acute schizophrenia: pooled analyses of phase 3 clinical studies.
Topics: Adult; Antipsychotic Agents; Clinical Trials, Phase III as Topic; Double-Blind Method; Glucose; Humans; Longitudinal Studies; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes; Triglycerides; Weight Gain | 2018 |
T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Drug Discovery; Humans; Indolizines; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Targeted Therapy; Neoplasms; Quinolones; Quinoxalines; Thiophenes; Treatment Outcome | 2018 |
Adjunctive Brexpiprazole and Functioning in Major Depressive Disorder: A Pooled Analysis of Six Randomized Studies Using the Sheehan Disability Scale.
Topics: Antidepressive Agents; Depressive Disorder, Major; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; Humans; Prospective Studies; Quinolones; Randomized Controlled Trials as Topic; Serotonin Agents; Single-Blind Method; Thiophenes | 2019 |
Brexpiprazole: A Review in Schizophrenia.
Topics: Antipsychotic Agents; Aripiprazole; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Approval; Humans; Japan; Quinolones; Schizophrenia; Serotonin Receptor Agonists; Thiophenes; United States | 2019 |
Novel antipsychotics specificity profile: A clinically oriented review of lurasidone, brexpiprazole, cariprazine and lumateperone.
Topics: Animals; Antipsychotic Agents; Heterocyclic Compounds, 4 or More Rings; Humans; Lurasidone Hydrochloride; Mental Disorders; Piperazines; Quinolones; Thiophenes | 2019 |
Brexpiprazole as Adjunctive Treatment for Major Depressive Disorder Following Treatment Failure With at Least One Antidepressant in the Current Episode: a Systematic Review and Meta-Analysis.
Topics: Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Drug Therapy, Combination; Humans; Outcome Assessment, Health Care; Quinolones; Randomized Controlled Trials as Topic; Serotonin Agents; Thiophenes | 2019 |
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia.
Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes | 2020 |
Aripiprazole vs. brexpiprazole for acute schizophrenia: a systematic review and network meta-analysis.
Topics: Acute Disease; Akathisia, Drug-Induced; Antipsychotic Agents; Aripiprazole; Humans; Network Meta-Analysis; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes; Weight Gain | 2020 |
Efficacy and safety of brexpiprazole in acute management of psychiatric disorders: a meta-analysis of randomized controlled trials.
Topics: Antipsychotic Agents; Aripiprazole; Depressive Disorder, Major; Humans; Psychiatric Status Rating Scales; Quetiapine Fumarate; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome | 2020 |
Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Dopamine Agonists; Humans; Piperazines; Quinolones; Receptors, Dopamine D2; Receptors, Dopamine D3; Schizophrenia; Thiophenes | 2020 |
A New Paradigm for Achieving a Rapid Antidepressant Response.
Topics: Antidepressive Agents; Depressive Disorder; Humans; Ketamine; Quinolones; Thiophenes | 2020 |
New antipsychotic drugs for the treatment of agitation and psychosis in Alzheimer's disease: focus on brexpiprazole and pimavanserin.
Topics: Alzheimer Disease; Antipsychotic Agents; Anxiety; Humans; Piperidines; Psychotic Disorders; Quinolones; Thiophenes; Urea | 2020 |
Brexpiprazole for the Treatment of Schizophrenia in Adults: An Overview of Its Clinical Efficacy and Safety and a Psychiatrist's Perspective.
Topics: Adult; Antipsychotic Agents; Dopamine Agonists; Humans; Psychiatry; Quinolones; Receptors, Dopamine D2; Schizophrenia; Thiophenes; Treatment Outcome | 2020 |
The action of aripiprazole and brexpiprazole at the receptor level in
Topics: Aripiprazole; Hiccup; Humans; Neurotransmitter Agents; Quinolones; Thiophenes | 2021 |
Discovery research and development history of the dopamine D
Topics: Aripiprazole; Depressive Disorder, Major; Dopamine; Dopamine Agonists; Humans; Quinolones; Research; Thiophenes; United States | 2021 |
Brexpiprazole for the Treatment of Schizophrenia and Major Depressive Disorder: A Comprehensive Review of Pharmacological Considerations in Clinical Practice.
Topics: Antipsychotic Agents; Depressive Disorder, Major; Humans; Quinolones; Schizophrenia; Thiophenes | 2021 |
Optimal dose of brexpiprazole for augmentation therapy of antidepressant-refractory depression: A systematic review and dose-effect meta-analysis.
Topics: Adolescent; Adult; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Female; Humans; Male; Quinolones; Randomized Controlled Trials as Topic; Reproducibility of Results; Thiophenes | 2022 |
The dilemma of polypharmacy in psychosis: is it worth combining partial and full dopamine modulation?
Topics: Antipsychotic Agents; Aripiprazole; Dopamine; Dopamine Agonists; Dopamine Antagonists; Humans; Polypharmacy; Psychotic Disorders; Quinolones; Thiophenes | 2022 |
Management of neuropsychiatric symptoms in dementia.
Topics: Alzheimer Disease; Antipsychotic Agents; Apathy; Humans; Quinolones; Thiophenes; United States | 2023 |
32 trial(s) available for thiophenes and carbostyril
| Article | Year |
|---|---|
Pulmonary delivery of a dopamine D-1 agonist, ABT-431, in dogs and humans.
Topics: Absorption; Adult; Aerosol Propellants; Aerosols; Animals; Area Under Curve; Biological Availability; Dogs; Dopamine Agonists; Double-Blind Method; Humans; Injections, Intravenous; Lung; Male; Nebulizers and Vaporizers; Particle Size; Prodrugs; Pyridines; Quinolones; Receptors, Dopamine D1; Tetrahydronaphthalenes; Thiophenes | 1999 |
Pilot study of augmentation with aripiprazole for incomplete response in late-life depression: getting to remission.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Citalopram; Cyclohexanols; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Therapy, Combination; Duloxetine Hydrochloride; Feasibility Studies; Female; Humans; Male; Personality Inventory; Pilot Projects; Piperazines; Quinolones; Thiophenes; Venlafaxine Hydrochloride | 2009 |
A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia.
Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes; Treatment Outcome; Young Adult | 2015 |
Efficacy and Safety of Brexpiprazole for the Treatment of Acute Schizophrenia: A 6-Week Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Blood Glucose; Double-Blind Method; Female; Humans; Lipids; Male; Psychiatric Status Rating Scales; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome; Weight Gain | 2015 |
Efficacy and safety of adjunctive brexpiprazole 2 mg in major depressive disorder: a phase 3, randomized, placebo-controlled study in patients with inadequate response to antidepressants.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Quinolones; Thiophenes; Treatment Outcome; Young Adult | 2015 |
Adjunctive brexpiprazole 1 and 3 mg for patients with major depressive disorder following inadequate response to antidepressants: a phase 3, randomized, double-blind study.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Quinolones; Thiophenes; Treatment Outcome; Young Adult | 2015 |
The effect of brexpiprazole (OPC-34712) and aripiprazole in adult patients with acute schizophrenia: results from a randomized, exploratory study.
Topics: Acute Disease; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Aripiprazole; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes; Treatment Outcome; Weight Gain | 2016 |
Brexpiprazole as adjunctive treatment of major depressive disorder with anxious distress: Results from a post-hoc analysis of two randomised controlled trials.
Topics: Adult; Antidepressive Agents; Anxiety Disorders; Depression; Depressive Disorder, Major; Dopamine Agonists; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Psychomotor Agitation; Quinolones; Serotonin Agents; Thiophenes; Treatment Outcome | 2016 |
Brexpiprazole as an adjunctive treatment in young adults with major depressive disorder who are in a school or work environment.
Topics: Adolescent; Adult; Antidepressive Agents; Depressive Disorder, Major; Drug Administration Schedule; Drug Therapy, Combination; Employment; Female; Follow-Up Studies; Humans; Male; Psychiatric Status Rating Scales; Quinolones; Students; Thiophenes; Treatment Outcome; Young Adult | 2016 |
Adjunctive Brexpiprazole in Patients With Major Depressive Disorder and Irritability: An Exploratory Study.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Irritable Mood; Male; Middle Aged; Outcome Assessment, Health Care; Quinolones; Serotonin Agents; Thiophenes | 2016 |
Efficacy and Safety of Brexpiprazole (OPC-34712) as Maintenance Treatment in Adults with Schizophrenia: a Randomized, Double-Blind, Placebo-Controlled Study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Proportional Hazards Models; Psychiatric Status Rating Scales; Quinolones; Recurrence; Schizophrenia; Thiophenes; Treatment Outcome; Young Adult | 2017 |
The effect of brexpiprazole in adult outpatients with early-episode schizophrenia: an exploratory study.
Topics: Adult; Ambulatory Care; Antipsychotic Agents; Dose-Response Relationship, Drug; Early Diagnosis; Female; Follow-Up Studies; Humans; Male; Outpatients; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes; Treatment Outcome; Young Adult | 2016 |
Adjunctive brexpiprazole in patients with major depressive disorder and anxiety symptoms: an exploratory study.
Topics: Anxiety; Depressive Disorder, Major; Dopamine Agonists; Drug Therapy, Combination; Female; Humans; Least-Squares Analysis; Male; Middle Aged; Psychiatric Status Rating Scales; Psychotropic Drugs; Quinolones; Serotonin Agents; Thiophenes; Treatment Outcome | 2016 |
Switching from Inadequate Adjunctive or Combination Treatment Options to Brexpiprazole Adjunctive to Antidepressant: An Open-Label Study on the Effects on Depressive Symptoms and Cognitive and Physical Functioning.
Topics: Antidepressive Agents; Aripiprazole; Bupropion; Central Nervous System Stimulants; Cognition; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Drug Therapy, Combination; Female; Humans; Impulsive Behavior; Male; Middle Aged; Psychiatric Status Rating Scales; Quetiapine Fumarate; Quinolones; Sleep; Thiophenes; Treatment Outcome | 2017 |
Effects of Adjunctive Brexpiprazole on Sleep Disturbances in Patients With Major Depressive Disorder: An Open-Label, Flexible-Dose, Exploratory Study.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Dopamine Agonists; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Quinolones; Serotonin Agents; Sleep Wake Disorders; Thiophenes; Treatment Outcome | 2016 |
Brexpiprazole in patients with schizophrenia: overview of short- and long-term phase 3 controlled studies.
Topics: Adult; Antipsychotic Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome | 2017 |
Pharmacokinetics and Safety of Brexpiprazole Following Multiple-Dose Administration to Japanese Patients With Schizophrenia.
Topics: Antipsychotic Agents; Area Under Curve; Asian People; Cytochrome P-450 CYP2D6; Depressive Disorder, Major; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Quinolones; Schizophrenia; Thiophenes | 2018 |
Efficacy of adjunctive brexpiprazole on the core symptoms of major depressive disorder: A post hoc analysis of two pooled clinical studies.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Quinolones; Serotonin Agents; Thiophenes; Treatment Outcome | 2018 |
A case study in identifying targeted patients population in major depressive disorder by enhanced enrichment design.
Topics: Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Delivery Systems; Humans; Patient Selection; Quinolones; Serotonin Agents; Thiophenes; Treatment Outcome | 2018 |
Efficacy and safety of flexibly dosed brexpiprazole for the adjunctive treatment of major depressive disorder: a randomized, active-referenced, placebo-controlled study.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Headache; Humans; Male; Middle Aged; Prospective Studies; Psychomotor Agitation; Quetiapine Fumarate; Quinolones; Thiophenes; Treatment Outcome | 2018 |
A Long-Term, Open-Label Study to Evaluate the Safety and Tolerability of Brexpiprazole as Maintenance Treatment in Adults with Schizophrenia.
Topics: Adult; Antipsychotic Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Quinolones; Schizophrenia; Secondary Prevention; Thiophenes | 2018 |
Long-term safety and effectiveness of brexpiprazole in Japanese patients with schizophrenia: A 52-week, open-label study.
Topics: Adult; Aged; Antipsychotic Agents; Female; Humans; Japan; Male; Middle Aged; Outcome Assessment, Health Care; Quinolones; Schizophrenia; Thiophenes | 2018 |
Efficacy and safety of brexpiprazole for the treatment of acute schizophrenia in Japan: A 6-week, randomized, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Japan; Male; Middle Aged; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome; Young Adult | 2018 |
A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Fixed-Dose Brexpiprazole 2 mg/d as Adjunctive Treatment of Adults With Major Depressive Disorder.
Topics: Adult; Antidepressive Agents; Anxiety; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Psychiatric Status Rating Scales; Quinolones; Thiophenes; Treatment Outcome; Young Adult | 2018 |
A randomised, placebo-controlled 24-week study evaluating adjunctive brexpiprazole in patients with major depressive disorder.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Prospective Studies; Quinolones; Serotonin Agents; Thiophenes; Young Adult | 2019 |
Successful switching of patients with acute schizophrenia from another antipsychotic to brexpiprazole: comparison of clinicians' choice of cross-titration schedules in a post hoc analysis of a randomized, double-blind, maintenance treatment study.
Topics: Adult; Antipsychotic Agents; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Quinolones; Schizophrenia; Thiophenes | 2019 |
Changes in Metabolic Parameters and Body Weight in Patients With Major Depressive Disorder Treated With Adjunctive Brexpiprazole: Pooled Analysis of Phase 3 Clinical Studies.
Topics: Adult; Antidepressive Agents; Blood Glucose; Body Weight; Cholesterol; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Long-Term Care; Male; Middle Aged; Quinolones; Thiophenes; Triglycerides | 2019 |
Post-hoc analysis investigating the safety and efficacy of brexpiprazole in Japanese patients with schizophrenia who were switched from other antipsychotics in a long-term study (Secondary Publication).
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; Drug Substitution; Female; Headache; Humans; Japan; Longitudinal Studies; Male; Middle Aged; Quinolones; Schizophrenia; Schizophrenic Psychology; Sleep Initiation and Maintenance Disorders; Thiophenes; Treatment Outcome; Young Adult | 2020 |
Effect of brexpiprazole on control of impulsivity in schizophrenia: A randomized functional magnetic resonance imaging study.
Topics: Adult; Cerebral Cortex; Dopamine Agonists; Double-Blind Method; Female; Humans; Impulsive Behavior; Inhibition, Psychological; Magnetic Resonance Imaging; Male; Middle Aged; Quinolones; Schizophrenia; Task Performance and Analysis; Thiophenes; Treatment Outcome; Young Adult | 2020 |
Efficacy and safety of brexpiprazole in patients with schizophrenia presenting with severe symptoms:
Topics: Adult; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurotransmitter Agents; Outcome Assessment, Health Care; Quinolones; Schizophrenia; Severity of Illness Index; Thiophenes | 2020 |
Two randomized, double-blind, placebo-controlled trials and one open-label, long-term trial of brexpiprazole for the acute treatment of bipolar mania.
Topics: Adult; Bipolar Disorder; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Quinolones; Serotonin Agents; Thiophenes; Treatment Outcome | 2021 |
Efficacy of adjunctive brexpiprazole on symptom clusters of major depressive disorder: A post hoc analysis of four clinical studies.
Topics: Adult; Anhedonia; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Fatigue; Humans; Quinolones; Syndrome; Thiophenes; Treatment Outcome | 2022 |
126 other study(ies) available for thiophenes and carbostyril
| Article | Year |
|---|---|
(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac
Topics: Acetylation; Animals; Behavior, Animal; Drug Administration Schedule; Humans; Prodrugs; Protein Precursors; Pyridines; Quinolones; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2; Structure-Activity Relationship; Tetrahydronaphthalenes; Thiophenes | 1995 |
ABT-431: the diacetyl prodrug of A-86929, a potent and selective dopamine D1 receptor agonist: in vitro characterization and effects in animal models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Callithrix; CHO Cells; Corpus Striatum; Cricetinae; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Fishes; Humans; Kinetics; Male; Mice; Parkinson Disease, Secondary; Prodrugs; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Tetrahydronaphthalenes; Thiophenes | 1996 |
Hyperactivity and behavioral seizures in rodents following treatment with the dopamine D1 receptor agonists A-86929 and ABT-431.
Topics: Animals; Behavior, Animal; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Oxidopamine; Prodrugs; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Seizures; Sympathectomy, Chemical; Tetrahydronaphthalenes; Thiophenes | 1996 |
The selective dopamine D1 receptor agonist A-86929 maintains efficacy with repeated treatment in rodent and primate models of Parkinson's disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Macaca nemestrina; Male; Parkinson Disease; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Rotation; Tetrahydronaphthalenes; Thiophenes | 1997 |
Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo.
Topics: Adenylyl Cyclases; Animals; Benzazepines; Binding, Competitive; Cell Membrane; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Fishes; Mice; Molecular Structure; Oxidopamine; Parkinson Disease, Secondary; Quinolones; Receptors, Dopamine; Retina; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Tritium; Yohimbine | 1997 |
Potential therapeutic use of the selective dopamine D1 receptor agonist, A-86929: an acute study in parkinsonian levodopa-primed monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Dopamine Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Motor Activity; Parkinson Disease, Secondary; Quinolones; Quinpirole; Receptors, Dopamine D1; Thiophenes | 1997 |
Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Contraceptive Agents, Female; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Estrus; Female; Fertilization; Heart Rate; Hypoxanthine; Isoenzymes; Meiosis; Menotropins; Mice; Mice, Inbred C57BL; Milrinone; Oogenesis; Ovarian Follicle; Ovulation; Ovulation Induction; Phosphodiesterase Inhibitors; Pregnancy; Purinones; Pyridazines; Pyridones; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Rolipram; Second Messenger Systems; Substrate Specificity; Thiophenes | 1998 |
Actions of the D1 agonists A-77636 and A-86929 on locomotion and dyskinesia in MPTP-treated L-dopa-primed common marmosets.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Animals; Benzopyrans; Callithrix; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Female; Levodopa; Locomotion; Male; Quinolones; Receptors, Dopamine D1; Thiophenes | 1999 |
The effects of central aromatic amino acid DOPA decarboxylase inhibition on the motor actions of L-DOPA and dopamine agonists in MPTP-treated primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Callithrix; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hydrazines; Levodopa; Male; Motor Activity; Quinolones; Quinpirole; Thiophenes; Tyrosine | 2000 |
Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Feasibility Studies; Female; Macaca mulatta; Meiosis; Milrinone; Oocytes; Phosphodiesterase Inhibitors; Quinolones; Rolipram; Thiophenes | 2002 |
Antituberculosis agents IV: in vitro antimycobacterial activity and cytotoxicity of N-piperazinyl quinolone derivatives containing 2-thienyl and 2-furyl moiety.
Topics: Animals; Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Chlorocebus aethiops; Drug Screening Assays, Antitumor; Furans; Humans; Macrophages; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Quinolones; Structure-Activity Relationship; Thiophenes; Vero Cells | 2003 |
Novel derivatives of benzo[b]thieno[2,3-c]quinolones: synthesis, photochemical synthesis, and antitumor evaluation.
Topics: Alkylation; Annexin A5; Antineoplastic Agents; Apoptosis; DNA, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Hydrolysis; Indicators and Reagents; Magnetic Resonance Spectroscopy; Photochemistry; Quinolones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiophenes | 2003 |
Construction of arene-fused-piperidine motifs by asymmetric addition of 2-trityloxymethylaryllithiums to nitroalkenes: the asymmetric synthesis of a dopamine D1 full agonist, A-86929.
Topics: Alkenes; Dopamine Agonists; Lithium; Nitro Compounds; Organometallic Compounds; Piperidines; Quinolones; Receptors, Dopamine D1; Stereoisomerism; Thiophenes | 2004 |
Novel cyano- and N-isopropylamidino-substituted derivatives of benzo[b]thiophene-2-carboxanilides and benzo[b]thieno[2,3-c]quinolones: synthesis, photochemical synthesis, crystal structure determination, and antitumor evaluation. 2.
Topics: Amidines; Anilides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; DNA; Drug Screening Assays, Antitumor; Fibroblasts; Humans; Models, Molecular; Molecular Structure; Nitriles; Quinolones; RNA; Structure-Activity Relationship; Thiophenes | 2005 |
Effects of long-term in vitro exposure to phosphodiesterase type-3 inhibitors on follicle and oocyte development.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 3; Female; Follicular Phase; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microscopy, Fluorescence; Oocytes; Oogenesis; Ovarian Follicle; Ovulation; Quinolones; Thiophenes; Time Factors | 2005 |
Novel cyano- and amidino-substituted derivatives of thieno[2,3-b]- and thieno[3,2-b]thiophene-2-carboxanilides and thieno[3',2':4,5]thieno- and thieno[2',3':4,5]thieno [2,3-c]quinolones: synthesis, photochemical synthesis, DNA binding, and antitumor evalu
Topics: Amidines; Antineoplastic Agents; Cell Line, Tumor; Cyanides; DNA; Humans; Photochemistry; Quinolones; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiophenes | 2006 |
Synthesis and antibacterial activity of N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] and N-[2-[5-(methylthio)thiophen-2-yl]-2-(oxyimino)ethyl]piperazinylquinolone derivatives.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Microbial Sensitivity Tests; Molecular Structure; Piperazines; Quinolones; Staphylococcus; Thiophenes | 2006 |
Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacterial Proteins; Cell Line, Tumor; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Drug Screening Assays, Antitumor; Ethidium; Humans; Indicators and Reagents; Macrolides; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Quinolones; Staphylococcus aureus; Structure-Activity Relationship; Thiophenes | 2007 |
An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia.
Topics: Animals; Blood Glucose; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucose; Glucose Tolerance Test; Glycogen Phosphorylase; Glycogen Synthase; Hepatocytes; Hyperglycemia; Inhibitory Concentration 50; Male; Obesity; Quinolones; Rats; Rats, Wistar; Rats, Zucker; Thiophenes | 2007 |
Chemical and photochemical synthesis of substituted dihydro-thieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones and tetrahydro-dithieno[2,3-b:2',3'-d]thieno[2'',3''c:2'',3''c']diquinolin-6,14-dione.
Topics: Anilides; Antineoplastic Agents; Chemistry, Organic; Cyclization; Heterocyclic Compounds; Models, Biological; Organic Chemistry Phenomena; Photochemistry; Quinolones; Thiophenes | 2005 |
Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators.
Topics: Computer Simulation; Humans; Hydrogen Bonding; Indoles; Inhibitory Concentration 50; Isoxazoles; Models, Molecular; Multidrug Resistance-Associated Proteins; Pyrimidines; Pyrroles; Quantitative Structure-Activity Relationship; Quinolones; Quinoxalines; Silymarin; Sulfonamides; Thiophenes | 2008 |
Antidepressant-induced sweating alleviated by aripiprazole.
Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Dopamine Agonists; Duloxetine Hydrochloride; Female; Fluoxetine; Humans; Hyperhidrosis; Middle Aged; Piperazines; Quinolones; Sweating; Thiophenes | 2008 |
QSAR analysis of antitumor active amides and quinolones from thiophene series.
Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Principal Component Analysis; Quantitative Structure-Activity Relationship; Quinolones; Thiophenes | 2010 |
Increased aripiprazole concentrations in an HIV-positive male concurrently taking duloxetine, darunavir, and ritonavir.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety; Aripiprazole; Cytochrome P-450 Enzyme Inhibitors; Darunavir; Depression; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; HIV Infections; HIV Protease Inhibitors; Humans; Male; Piperazines; Quinolones; Ritonavir; Sulfonamides; Thiophenes | 2010 |
The effect of coadministration of duloxetine on steady-state serum concentration of risperidone and aripiprazole: a study based on therapeutic drug monitoring data.
Topics: Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Aripiprazole; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Piperazines; Quinolones; Risperidone; Selective Serotonin Reuptake Inhibitors; Thiophenes | 2010 |
DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype.
Topics: Benzopyrans; Cell Membrane Permeability; DNA Damage; DNA-Activated Protein Kinase; Furans; HeLa Cells; Humans; Pyridines; Pyrimidinones; Quinolones; Small Molecule Libraries; Structure-Activity Relationship; Thiophenes | 2010 |
Aripiprazole augmentation induced hypertension in major depressive disorder: a case report.
Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Depressive Disorder, Major; Drug Synergism; Duloxetine Hydrochloride; Female; Humans; Hypertension; Middle Aged; Piperazines; Quinolones; Thiophenes | 2011 |
Catalytic enantioselective synthesis of A-86929, a dopamine D1 agonist.
Topics: Catalysis; Cyclization; Dopamine Agonists; Quinolones; Stereoisomerism; Thiophenes | 2011 |
Novel substituted benzothiophene and thienothiophene carboxanilides and quinolones: synthesis, photochemical synthesis, DNA-binding properties, antitumor evaluation and 3D-derived QSAR analysis.
Topics: Anilides; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; DNA; Drug Screening Assays, Antitumor; Humans; Nucleic Acid Denaturation; Photochemical Processes; Principal Component Analysis; Quantitative Structure-Activity Relationship; Quinolones; Thiophenes; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2012 |
Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication.
Topics: Animals; Behavior, Animal; Brain; Calcium; Carboxylic Acids; CHO Cells; Cholinergic Fibers; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Maze Learning; Memory; Microdialysis; Motor Activity; Muscarinic Agonists; Muscarinic Antagonists; Nootropic Agents; Quinolones; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Salivation; Scopolamine; Thiophenes; Transfection | 2012 |
[Is there a place for the physician's hopelesness in the treatment of depression?].
Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Chronic Disease; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Drug Therapy, Combination; Duloxetine Hydrochloride; Humans; Male; Middle Aged; Physician's Role; Piperazines; Quinolones; Remission Induction; Risk Factors; Thiophenes; Treatment Outcome | 2013 |
Efficient synthesis of 4-oxo-4,5-dihydrothieno[3,2-c]quinoline-2-carboxylic acid derivatives from aniline.
Topics: Aniline Compounds; Carboxylic Acids; Chemistry Techniques, Synthetic; Quinolones; Temperature; Thiophenes | 2014 |
Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties.
Topics: Anilides; Antineoplastic Agents; Cell Line, Tumor; Cytostatic Agents; DNA; Drug Screening Assays, Antitumor; Humans; Neoplasms; Nitrogen; Quantitative Structure-Activity Relationship; Quinolones; Thiophenes; Topoisomerase II Inhibitors | 2014 |
Molecular modeling and residue interaction network studies on the mechanism of binding and resistance of the HCV NS5B polymerase mutants to VX-222 and ANA598.
Topics: Antiviral Agents; Benzothiadiazines; Binding Sites; Cyclohexanols; Drug Resistance, Viral; Enzyme Inhibitors; Humans; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Protein Binding; Quinolones; Thiophenes; Viral Nonstructural Proteins | 2014 |
Response to antidepressant medications in late-life depression across the spectrum of cognitive functioning.
Topics: Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Aripiprazole; Citalopram; Cognitive Dysfunction; Cyclohexanols; Dementia; Depressive Disorder, Major; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Humans; Male; Piperazines; Quinolones; Randomized Controlled Trials as Topic; Recurrence; Selective Serotonin Reuptake Inhibitors; Thiophenes; Time Factors; Venlafaxine Hydrochloride | 2014 |
Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.
Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Humans; Male; Protein Binding; Quinolones; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Serotonin; Serotonin Agents; Thiophenes | 2014 |
Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.
Topics: Animals; Cognition Disorders; Male; Mice; Mice, Inbred ICR; Phencyclidine; Quinolones; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine; Thiophenes | 2014 |
Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization.
Topics: Action Potentials; Animals; Dopamine; Electrophysiological Phenomena; Male; Neurons; Norepinephrine; Quinolones; Rats; Rats, Sprague-Dawley; Serotonin; Thiophenes; Time Factors | 2014 |
Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator.
Topics: Analysis of Variance; Animals; Cognition Disorders; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred C57BL; Quinolones; Recognition, Psychology; Serotonin Agents; Social Behavior; Thiophenes | 2015 |
Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors.
Topics: Animals; Aripiprazole; Boron Compounds; Dose-Response Relationship, Drug; Drug Synergism; Fluorobenzenes; HSP90 Heat-Shock Proteins; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Nerve Growth Factor; Neurites; Oxazoles; PC12 Cells; Piperazines; Piperidines; Pyridines; Quinolones; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Serotonin Agents; Thiophenes | 2015 |
Brexpiprazole: another multipurpose antipsychotic drug?
Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Depressive Disorder, Major; Humans; Psychomotor Agitation; Quinolones; Schizophrenia; Stress Disorders, Post-Traumatic; Thiophenes | 2015 |
American Psychiatric Association - 168th Annual Meeting (May 16-20, 2015 - Toronto, Canada).
Topics: Alcoholism; Benzofurans; Canada; Drug Discovery; Humans; Indoles; Mental Disorders; Piperazines; Psychiatry; Quinolones; Schizophrenia; Thiophenes; Vilazodone Hydrochloride | 2015 |
Brexpiprazole: A New Antipsychotic Following in the Footsteps of Aripiprazole.
Topics: Antipsychotic Agents; Female; Humans; Male; Quinolones; Schizophrenia; Thiophenes | 2015 |
Brexpiprazole Alters Monoaminergic Systems following Repeated Administration: an in Vivo Electrophysiological Study.
Topics: Action Potentials; Animals; Body Weight; Brain; Dopamine; Male; Neurons; Neurotransmitter Agents; Norepinephrine; Psychotropic Drugs; Quinolones; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Serotonin; Thiophenes; Time Factors; Tissue Culture Techniques | 2015 |
The ABC's of dopamine receptor partial agonists - aripiprazole, brexpiprazole and cariprazine: the 15-min challenge to sort these agents out.
Topics: Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Depressive Disorder, Major; Dopamine Agonists; Drug Administration Schedule; Drug Interactions; Humans; Piperazines; Quinolones; Schizophrenia; Thiophenes | 2015 |
Mechanism of action of brexpiprazole: comparison with aripiprazole.
Topics: Adrenergic alpha-1 Receptor Antagonists; Antipsychotic Agents; Aripiprazole; Depressive Disorder, Major; Dopamine Agonists; Humans; Quinolones; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Agents; Thiophenes | 2016 |
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds.
Topics: Bacterial Proteins; Benzoates; Carboxylic Acids; Crystallography, X-Ray; Drug Discovery; Fluorometry; Pseudomonas aeruginosa; Pyocyanine; Pyridines; Pyrroles; Quinolones; Quorum Sensing; Thiolester Hydrolases; Thiophenes; Virulence; Virulence Factors | 2016 |
New drugs 2016, part 2.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzimidazoles; Carbamates; Drug Approval; Drug Therapy; Humans; Imidazoles; Nitriles; Pyridines; Pyrrolidines; Quinolones; Thiophenes; Triazoles; United States; United States Food and Drug Administration; Valine | 2016 |
T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer.
Topics: Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Disease-Free Survival; Female; Forkhead Box Protein M1; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Prognosis; Protein Kinase Inhibitors; Quinolones; Thiophenes | 2016 |
Cost-effectiveness of brexpiprazole adjunctive treatment for major depressive disorder.
Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Cost-Benefit Analysis; Depressive Disorder, Major; Disorders of Excessive Somnolence; Drug Costs; Drug Therapy, Combination; Fatigue; Female; Health Care Costs; Humans; Male; Middle Aged; Models, Economic; Olanzapine; Patient Selection; Quetiapine Fumarate; Quinolones; Serotonin Agents; Thiophenes; Weight Gain; Young Adult | 2017 |
Variation in toxicity during the biodegradation of various heterocyclic and homocyclic aromatic hydrocarbons in single and multi-substrate systems.
Topics: Benzofurans; Biodegradation, Environmental; Chryseobacterium; Environmental Pollutants; Escherichia coli; Hydrocarbons, Aromatic; Naphthalenes; Oxidoreductases; Pseudomonas fluorescens; Quinolones; Thiophenes | 2017 |
Adjunctive brexpiprazole for the treatment of major depressive disorder.
Topics: Antidepressive Agents; Antipsychotic Agents; Chemotherapy, Adjuvant; Depressive Disorder, Major; Dopamine; Humans; Quinolones; Randomized Controlled Trials as Topic; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT1; Serotonin 5-HT1 Receptor Agonists; Thiophenes; Treatment Outcome | 2016 |
Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Dendritic Spines; Depression; Fluoxetine; Inflammation; Male; Mice; Neurons; Prefrontal Cortex; Quinolones; Signal Transduction; Thiophenes | 2017 |
Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling.
Topics: Animals; Antidepressive Agents; Azepines; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Dendritic Spines; Depressive Disorder, Major; Disease Models, Animal; Drug Therapy, Combination; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Phenotype; Quinolones; Receptor, trkB; Selective Serotonin Reuptake Inhibitors; Signal Transduction; Thiophenes | 2016 |
TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer.
Topics: Cell Proliferation; Forkhead Box Protein M1; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase Kinases; Neoplastic Stem Cells; Quinolones; RNA Interference; RNA, Small Interfering; Small Cell Lung Carcinoma; Spheroids, Cellular; Thiophenes; Thy-1 Antigens; Tumor Cells, Cultured | 2017 |
Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Choice Behavior; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Exploratory Behavior; Female; Gene Knockdown Techniques; Impulsive Behavior; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenotype; Quinolones; Receptor, Serotonin, 5-HT1A; Risk-Taking; Serotonin Agents; Thiophenes | 2017 |
The novel antipsychotic drug brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism.
Topics: Animals; Citalopram; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Combinations; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neurotransmitter Agents; Patch-Clamp Techniques; Prefrontal Cortex; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Thiophenes | 2017 |
Efficacy of Brexpiprazole as Adjunctive Treatment in Major Depressive Disorder With Irritability: Post Hoc Analysis of 2 Pivotal Clinical Studies.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Depressive Disorder, Major; Drug Therapy, Combination; Humans; Irritable Mood; Middle Aged; Quinolones; Thiophenes | 2017 |
Alterations in amino acid levels in mouse brain regions after adjunctive treatment of brexpiprazole with fluoxetine: comparison with (R)-ketamine.
Topics: Administration, Oral; Amino Acids; Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Fluoxetine; Ketamine; Male; Mice; Mice, Inbred C57BL; Quinolones; Receptors, N-Methyl-D-Aspartate; Thiophenes | 2017 |
The use of brexpiprazole amongst individuals with insufficient outcomes with aripiprazole or bupropion: A case series.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Bupropion; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; New York; Psychiatric Status Rating Scales; Quinolones; Retrospective Studies; Thiophenes; Treatment Outcome; Young Adult | 2018 |
A Validated Quantification Method for Brexpiprazole in Dog Plasma.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dogs; Dopamine Agonists; Limit of Detection; Quinolones; Reproducibility of Results; Tandem Mass Spectrometry; Thiophenes | 2018 |
Changes in healthcare resource use and costs associated with early versus delayed initiation of atypical antipsychotic adjunctive treatment in major depressive disorder.
Topics: Adult; Age Factors; Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Comorbidity; Depressive Disorder, Major; Drug Administration Schedule; Drug Therapy, Combination; Female; Health Expenditures; Health Resources; Health Services; Humans; Insurance Claim Review; Lurasidone Hydrochloride; Male; Middle Aged; Models, Econometric; Quetiapine Fumarate; Quinolones; Residence Characteristics; Retrospective Studies; Sex Factors; Socioeconomic Factors; Thiophenes; Time-to-Treatment | 2018 |
The effects of brexpiprazole and aripiprazole on body weight as monotherapy in patients with schizophrenia and as adjunctive treatment in patients with major depressive disorder: an analysis of short-term and long-term studies.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Depressive Disorder, Major; Female; Humans; Longitudinal Studies; Male; Meta-Analysis as Topic; Middle Aged; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes; Weight Gain | 2018 |
Adjunctive brexpiprazole for elderly patients with major depressive disorder: An open-label, long-term safety and tolerability study.
Topics: Aged; Aged, 80 and over; Akathisia, Drug-Induced; Antidepressive Agents; Chemotherapy, Adjuvant; Depressive Disorder, Major; Europe; Fatigue; Female; Humans; Male; Quality of Life; Quinolones; Social Participation; Thiophenes; United States | 2018 |
Brexpiprazole: a step forward for precision medicine in resistant depression.
Topics: Antidepressive Agents; Depression; Humans; Precision Medicine; Quinolones; Serotonin Agents; Thiophenes | 2018 |
Medication Adherence, Health Care Utilization, and Costs in Patients With Major Depressive Disorder Initiating Adjunctive Atypical Antipsychotic Treatment.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Depressive Disorder, Major; Emergency Service, Hospital; Female; Health Care Costs; Hospitalization; Humans; Lurasidone Hydrochloride; Male; Medicaid; Medicare; Medication Adherence; Middle Aged; Patient Acceptance of Health Care; Quetiapine Fumarate; Quinolones; Thiophenes; United States; Young Adult | 2019 |
Clinical Use of Dopamine Modulators as Third-Generation Antipsychotic Agents.
Topics: Antipsychotic Agents; Aripiprazole; Dopamine D2 Receptor Antagonists; Humans; Quinolones; Receptors, Dopamine D2; Schizophrenia; Serotonin Antagonists; Thiophenes | 2019 |
A pilot study of brexpiprazole for bipolar depression.
Topics: Adult; Antidepressive Agents; Bipolar Disorder; Cognition; Depressive Disorder, Major; Female; Humans; Irritable Mood; Male; Middle Aged; Pilot Projects; Psychiatric Status Rating Scales; Quality of Life; Quinolones; Thiophenes; Treatment Outcome; Young Adult | 2019 |
TOPK is regulated by PP2A and BCR/ABL in leukemia and enhances cell proliferation.
Topics: Adult; Aged; Aged, 80 and over; Blast Crisis; Cell Line, Tumor; Cell Proliferation; Female; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; HLA-A24 Antigen; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Phosphatase 2; Quinolones; Thiophenes; Young Adult | 2019 |
In silico, in vitro and in vivo metabolite identification of brexpiprazole using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
Topics: Animals; Antipsychotic Agents; Chromatography, High Pressure Liquid; Computer Simulation; Humans; Male; Microsomes, Liver; Molecular Structure; Quinolones; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Thiophenes | 2019 |
Mechanotransduction of mitochondrial AMPK and its distinct role in flow-induced breast cancer cell migration.
Topics: AMP-Activated Protein Kinases; Biphenyl Compounds; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial Cells; Fluorescence Resonance Energy Transfer; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Humans; Mammary Glands, Human; Mechanotransduction, Cellular; Mitochondria; Organ Specificity; Pyrimidines; Pyrones; Quinolones; Rheology; src-Family Kinases; Stress, Mechanical; Sulfones; Thiophenes; Tumor Microenvironment | 2019 |
Activating and Sedating Properties of Medications Used for the Treatment of Major Depressive Disorder and Their Effect on Patient Functioning.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Anxiety Disorders; Aripiprazole; Arousal; Comorbidity; Delayed-Action Preparations; Depressive Disorder, Major; Drug Approval; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Practice Patterns, Physicians'; Quality of Life; Quetiapine Fumarate; Quinolones; Sleep Initiation and Maintenance Disorders; Thiophenes | 2019 |
Stability Indicating TLC Method for Quantification of Brexpiprazole in Bulk and Its Pharmaceutical Dosage Form and Determination of Content Uniformity.
Topics: Chromatography, Thin Layer; Densitometry; Drug Stability; Limit of Detection; Linear Models; Quinolones; Reproducibility of Results; Tablets; Thiophenes | 2019 |
Commentary on: Corponi F., Fabbri C, Bitter, I. Montgomery, S., Vieta, E., Kaspar, S., Pallanti S., Serretti A. Novel antipsychotics specificity profile: A clinically oriented review of lurasidone, brexpiprazole, cariprazine and lumateperone.
Topics: Antipsychotic Agents; Lurasidone Hydrochloride; Piperazines; Quinolones; Thiophenes | 2019 |
Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer.
Topics: Acrylamides; Aniline Compounds; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Male; Mice; Neoplastic Stem Cells; Protein Kinase Inhibitors; Quinolones; RNA, Small Interfering; Survivin; Thiophenes; Xenograft Model Antitumor Assays | 2019 |
Effects of 26 Recombinant CYP3A4 Variants on Brexpiprazole Metabolism.
Topics: Antipsychotic Agents; Cytochrome P-450 CYP3A; Dopamine Agonists; Molecular Docking Simulation; Molecular Dynamics Simulation; Quinolones; Recombinant Proteins; Serotonin Agents; Thiophenes | 2020 |
Treatment-resistant schizophrenia successfully maintained with brexpiprazole following abrupt withdrawal of clozapine due to neutropenia.
Topics: Adolescent; Antipsychotic Agents; Clozapine; Female; Humans; Neutropenia; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes | 2020 |
Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Drug Synergism; Female; Humans; Lenalidomide; Leukocytes, Mononuclear; Mice; Mitogen-Activated Protein Kinase Kinases; Multiple Myeloma; Primary Cell Culture; Protein Kinase Inhibitors; Quinolones; Thiophenes; Xenograft Model Antitumor Assays | 2020 |
[Preclinical pharmacological profiles and clinical efficacy of the novel antipsychotic drug brexpiprazole (REXULTI
Topics: Antipsychotic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Quinolones; Schizophrenia; Tablets; Thiophenes; Treatment Outcome | 2019 |
Association between previous high-dose antipsychotic therapy and brexpiprazole discontinuation after the initiation of brexpiprazole in patients with schizophrenia or schizoaffective disorder.
Topics: Antipsychotic Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Psychotic Disorders; Quinolones; Retrospective Studies; Schizophrenia; Serotonin Agents; Thiophenes; Withholding Treatment | 2020 |
Severe parkinsonism caused by brexpiprazole: A case report.
Topics: Aged; Antidepressive Agents; Depression; Dopamine Agonists; Female; Humans; Parkinsonian Disorders; Quinolones; Thiophenes | 2019 |
A Dilute and Shoot LC-MS/MS Method for Antipsychotics in Urine.
Topics: Antipsychotic Agents; Aripiprazole; Chromatography, Liquid; Drug Monitoring; Humans; Limit of Detection; Quinolones; Tandem Mass Spectrometry; Thiophenes | 2020 |
Are We Getting Better at Managing Agitation in Dementia?
Topics: Alzheimer Disease; Dementia; Double-Blind Method; Humans; Quinolones; Thiophenes | 2020 |
Comparisons of global tests on intersection hypotheses and their application in matched parallel gatekeeping procedures.
Topics: Antidepressive Agents; Clinical Trials, Phase III as Topic; Computer Simulation; Data Interpretation, Statistical; Depressive Disorder, Major; Dose-Response Relationship, Drug; Endpoint Determination; Humans; Models, Statistical; Quinolones; Randomized Controlled Trials as Topic; Research Design; Thiophenes; Treatment Outcome | 2020 |
Adjunctive therapy with brexpiprazole improves treatment resistant complex post traumatic stress disorder in domestic family violence victims.
Topics: Adult; Citalopram; Combined Modality Therapy; Desvenlafaxine Succinate; Domestic Violence; Drug Resistance; Drug Therapy, Combination; Female; Humans; Middle Aged; Psychotherapy; Quinolones; Stress Disorders, Post-Traumatic; Thiophenes | 2020 |
Health Care Cost in Patients With Schizophrenia Treated With Brexpiprazole Versus Other Oral Atypical Antipsychotic Therapy.
Topics: Administration, Oral; Adult; Antipsychotic Agents; Aripiprazole; Female; Health Care Costs; Hospitalization; Humans; Lurasidone Hydrochloride; Male; Medicaid; Medicare; Middle Aged; Olanzapine; Paliperidone Palmitate; Piperazines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Thiazoles; Thiophenes; United States | 2020 |
Effectiveness of brexpiprazole in the treatment in a patient with Huntington's disease.
Topics: Adult; Dopamine Agonists; Humans; Huntington Disease; Male; Quinolones; Thiophenes | 2020 |
1-(Benzo[b]thiophen-4-yl)piperazine Ring Induced Bioactivation of Brexpiprazole in Liver Microsomes: Identification and Characterization of Reactive Conjugates Using Ultra-High-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry.
Topics: Animals; Antipsychotic Agents; Chromatography, High Pressure Liquid; Cystine; Glutathione; Humans; Male; Microsomes, Liver; Quinolones; Rats; Tandem Mass Spectrometry; Thiophenes | 2020 |
Pediatric brexpiprazole toxicity.
Topics: Antipsychotic Agents; Drug Overdose; Glucose; Humans; Infant; Male; Quinolones; Thiophenes | 2020 |
Brexpiprazole improves behavioral and psychological symptoms of dementia in patients with dementia in the oldest old.
Topics: Aged, 80 and over; Behavioral Symptoms; Dementia; Humans; Quinolones; Thiophenes | 2020 |
Brexpiprazole in the treatment of schizophrenia and agitation in Alzheimer's disease.
Topics: Alzheimer Disease; Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes | 2020 |
Brexpiprazole blocks post-traumatic stress disorder-like memory while promoting normal fear memory.
Topics: Animals; Disease Models, Animal; Escitalopram; Fear; Mice; Quinolones; Stress Disorders, Post-Traumatic; Thiophenes | 2021 |
Combination therapy of brexpiprazole and aripiprazole for an adolescent patient with a first episode of schizophrenia: A case report.
Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Drug Therapy, Combination; Female; Humans; Quinolones; Schizophrenia; Serotonin Agents; Thiophenes | 2020 |
Hypomania in a depressed man following the introduction of brexpiprazole: A case report.
Topics: Humans; Male; Mania; Quinolones; Thiophenes | 2021 |
T-LAK cell-originated protein kinase (TOPK) is a Novel Prognostic and Therapeutic Target in Chordoma.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Chordoma; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Metastasis; Prognosis; Protein Kinase Inhibitors; Quinolones; RNA Interference; RNA, Small Interfering; Thiophenes | 2020 |
Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy.
Topics: Circadian Rhythm; Depressive Disorder, Major; Drug Therapy, Combination; Humans; Melatonin; Quinolones; Sleep; Thiophenes; Treatment Outcome | 2021 |
T-LAK cell-originated protein kinase (TOPK) enhances androgen receptor splice variant (ARv7) and drives androgen-independent growth in prostate cancer.
Topics: Alternative Splicing; Androgen Antagonists; Androgens; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell Line, Tumor; Disease-Free Survival; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Male; Mitogen-Activated Protein Kinase Kinases; Neoplasm Recurrence, Local; Prognosis; Prostate; Prostatic Neoplasms, Castration-Resistant; Protein Kinase Inhibitors; Quinolones; Receptors, Androgen; Signal Transduction; Thiophenes; Transcriptional Activation | 2021 |
Dual inhibition of FOXM1 and its compensatory signaling pathway decreased the survival of ovarian cancer cells.
Topics: Acetophenones; Benzopyrans; Cell Line, Tumor; Cell Survival; Female; Forkhead Box Protein M1; GTP Phosphohydrolases; Humans; Membrane Proteins; Ovarian Neoplasms; Pyridines; Quinazolines; Quinolones; Signal Transduction; Thiophenes | 2021 |
QbD-Based UPLC Method for Quantification of Brexpiprazole in Presence of Impurities and Application to In Vitro Dissolution.
Topics: Chromatography, High Pressure Liquid; Drug Contamination; Linear Models; Quinolones; Reproducibility of Results; Sensitivity and Specificity; Thiophenes | 2021 |
Copulatory Dyskinesia: Pathognomonic Manifestation of Tardive Dyskinesia.
Topics: Adrenergic beta-Antagonists; Aged; Aripiprazole; Clonazepam; Deprescriptions; Depressive Disorder; Drug Substitution; GABA Modulators; Humans; Male; Parkinsonian Disorders; Pelvis; Propranolol; Quinolones; Serotonin Agents; Tardive Dyskinesia; Tetrabenazine; Thiophenes; Treatment Failure; Valine | 2020 |
Safety of switching to brexpiprazole in Japanese patients with schizophrenia: A post-hoc analysis of a long-term open-label study.
Topics: Antipsychotic Agents; Aripiprazole; Humans; Japan; Quinolones; Schizophrenia; Thiophenes; Treatment Outcome | 2021 |
[Brexpiprazole for treatment of schizophrenia: a critical literature study].
Topics: Antipsychotic Agents; Belgium; Humans; Netherlands; Quinolones; Randomized Controlled Trials as Topic; Schizophrenia; Thiophenes; Treatment Outcome | 2021 |
PBK expression predicts favorable survival in colorectal cancer patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Caco-2 Cells; Cell Proliferation; Colorectal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Female; HCT116 Cells; Humans; Immunohistochemistry; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Staging; Phosphorylation; Protein Kinase Inhibitors; Quinolones; Risk Assessment; Risk Factors; Thiophenes; Time Factors; Treatment Outcome | 2021 |
Continuation rate for asenapine and brexpiprazole treatment in patients with schizophrenia.
Topics: Antipsychotic Agents; Dibenzocycloheptenes; Humans; Quinolones; Retrospective Studies; Schizophrenia; Thiophenes; Treatment Outcome | 2021 |
Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats.
Topics: Animals; Blood Glucose; Body Weight; Down-Regulation; Female; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Resistance; Intestine, Small; Liraglutide; Liver; Male; Metabolic Syndrome; Muscle, Skeletal; Pancreas; Quinolones; Rats; Signal Transduction; Thiophenes | 2021 |
Engineered PLGA microspheres for extended release of brexpiprazole:
Topics: Animals; Lactic Acid; Microspheres; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinolones; Rats; Thiophenes | 2021 |
Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43.
Topics: Animals; Antipsychotic Agents; Astrocytes; Cell Membrane; Cerebral Cortex; Clozapine; Connexin 43; Quetiapine Fumarate; Quinolones; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Thiophenes | 2021 |
Do cariprazine and brexpiprazole cause impulse control symptoms? A case/non-case study.
Topics: Antipsychotic Agents; Aripiprazole; Piperazines; Quinolones; Thiophenes | 2021 |
Investigation of the impact of grapefruit juice, pomegranate juice and tomato juice on pharmacokinetics of brexpiprazole in rats using UHPLC-QTOF-MS.
Topics: Animals; Chromatography, High Pressure Liquid; Citrus paradisi; Fruit and Vegetable Juices; Herb-Drug Interactions; Limit of Detection; Linear Models; Male; Mass Spectrometry; Pomegranate; Quinolones; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Solanum lycopersicum; Thiophenes | 2021 |
Brexpiprazole in the Treatment of Cannabis Withdrawal Psychotic Disorder.
Topics: Cannabis; Humans; Psychotic Disorders; Quinolones; Thiophenes | 2022 |
Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations.
Topics: Antipsychotic Agents; Area Under Curve; Cytochrome P-450 CYP2D6; Drug Administration Schedule; Genotype; Half-Life; Humans; Metabolic Clearance Rate; Models, Biological; Phenotype; Quinolones; Schizophrenia; Thiophenes | 2022 |
Effect of Novel Antipsychotics on Energy Metabolism - In Vitro Study in Pig Brain Mitochondria.
Topics: Adenosine Triphosphate; Animals; Antipsychotic Agents; Electron Transport Chain Complex Proteins; Energy Metabolism; Hydrogen Peroxide; Loxapine; Lurasidone Hydrochloride; Mitochondria; Monoamine Oxidase Inhibitors; Oxygen Consumption; Piperazines; Quinolones; Reactive Oxygen Species; Receptors, Neurotransmitter; Swine; Thiophenes | 2021 |
Continuation rate for asenapine and brexpiprazole treatment in elderly patients with schizophrenia.
Topics: Aged; Antipsychotic Agents; Dibenzocycloheptenes; Humans; Quinolones; Schizophrenia; Thiophenes | 2021 |
Hyperprolactinemia induced by brexpiprazole in patients with schizophrenia: A case report.
Topics: Antipsychotic Agents; Humans; Hyperprolactinemia; Quinolones; Schizophrenia; Thiophenes | 2021 |
Functional Outcomes of an Antipsychotic Medication in Schizophrenia: A Generalizable or Specific Effect?
Topics: Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes | 2022 |
Repurposing Drugs for Post-COVID-19 Fatigue Syndrome: Methylphenidate, Duloxetine, and Brexpiprazole.
Topics: COVID-19; Drug Repositioning; Duloxetine Hydrochloride; Fatigue; Humans; Methylphenidate; Quinolones; Thiophenes | 2022 |
A case report of clozapine-treatment-resistant schizophrenia successfully managed with brexpiprazole combination therapy.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Clozapine; Drug Therapy, Combination; Humans; Quinolones; Schizophrenia; Schizophrenia, Treatment-Resistant; Thiophenes; Young Adult | 2022 |
Impulse Control Disorders by Dopamine Partial Agonists: A Pharmacovigilance-Pharmacodynamic Assessment Through the FDA Adverse Event Reporting System.
Topics: Antipsychotic Agents; Aripiprazole; Disruptive, Impulse Control, and Conduct Disorders; Dopamine; Dopamine Agonists; Humans; Hyperphagia; Lurasidone Hydrochloride; Olanzapine; Pharmacovigilance; Quinolones; Receptors, Serotonin; Thiophenes; United States; United States Food and Drug Administration | 2022 |
Structure-Functional Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward the Discovery of Biased Dopamine D1 Receptor Agonists.
Topics: Animals; beta-Arrestins; Dopamine; Dopamine Agonists; GTP-Binding Proteins; Ligands; Quinolones; Receptors, Dopamine D1; Receptors, Dopamine D2; Thiophenes | 2022 |
Brexpiprazole Reduces 5-HT7 Receptor Function on Astroglial Transmission Systems.
Topics: AMP-Activated Protein Kinases; Animals; Antipsychotic Agents; Astrocytes; Connexin 43; Quinolones; Rats; Receptors, Serotonin; Thiophenes | 2022 |
Brexpiprazole 2 mg Starting Dose: A Case Series.
Topics: Antipsychotic Agents; Humans; Quinolones; Thiophenes | 2022 |
Treatment Discontinuation Among Patients with Schizophrenia Treated with Brexpiprazole and Other Oral Atypical Antipsychotics in Japan: A Retrospective Observational Study.
Topics: Antipsychotic Agents; Humans; Japan; Quinolones; Retrospective Studies; Schizophrenia; Thiophenes | 2022 |
Effects of adjunctive brexpiprazole on sleep-wake and circadian parameters in youth with depressive disorders: study protocol for a clinical trial.
Topics: Adolescent; Depressive Disorder, Major; Humans; Quinolones; Sleep; Sleep Wake Disorders; Thiophenes; Young Adult | 2022 |
Brexpiprazole (Rexulti) for agitation in Alzheimer's dementia.
Topics: Alzheimer Disease; Antipsychotic Agents; Humans; Psychomotor Agitation; Quinolones; Thiophenes | 2023 |
Population Pharmacokinetic Analysis of Brexpiprazole to Support its Indication and Dose Selection in Adolescents With Schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Child; Humans; Quinolones; Schizophrenia; Thiophenes | 2023 |
Brexpiprazole for the Treatment of Tics in a Patient With Schizophrenia.
Topics: Antipsychotic Agents; Humans; Quinolones; Schizophrenia; Thiophenes; Tics | 2023 |