thiophenes has been researched along with bx795 in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (65.52) | 24.3611 |
| 2020's | 10 (34.48) | 2.80 |
| Authors | Studies |
|---|---|
| Arthur, JS; Birchall, K; Bryans, J; Chugh, J; Clark, K; Cohen, P; Drake, T; Kamal, A; Levy, A; Lewis, SJ; McIver, EG; Newman, M; Osborne, J; Smiljanic-Hurley, E; Taylor, D; Tsang, W | 1 |
| Chi, ZL; Fukuda, K; Iejima, D; Iwata, T; Kawase, K; Kobayashi, H; Minegishi, Y; Seki, T; Yamamoto, T; Yuasa, S | 1 |
| Bray, P; Dangelmaier, C; Jin, J; Kunapuli, SP; Liverani, E; Manne, BK | 1 |
| Aplin, AE; Vu, HL | 1 |
| Derbigny, WA; Hosey, KL; Hu, S | 1 |
| Bosch, A; Guix, S; Miró, L; Moretó, M; Pérez-Bosque, A; Pintó, RM | 1 |
| Bedsaul, JR; Zaritsky, LA; Zoon, KC | 1 |
| Bai, LY; Chiu, CF; Kapuriya, NP; Sargeant, AM; Shieh, TM; Tsai, YC; Weng, JR; Wu, CY | 1 |
| Barrow, P; Cui, Y; Liu, C; Song, Z; Sreevatsan, S; Yang, L; Yang, W; Zhao, D; Zhou, X | 1 |
| Li, YL; Qiu, M; Song, HY; Song, SW; Su, AR; Wang, XH; Wu, ZW; Xu, WT; Zheng, N | 1 |
| Li, LU; Zhang, H; Zhao, Y | 1 |
| Bondet, V; Crow, YJ; Duffy, D; Frémond, ML; Hayday, A; Hertel, C; Kitabayashi, N; Melki, I; Neven, B; Rodero, MP; Rose, Y; Uggenti, C; Van Eyck, L | 1 |
| Radha, V; Sayyad, Z; Sirohi, K; Swarup, G | 1 |
| Agelidis, A; Ames, J; Hadigal, S; Jaishankar, D; Shukla, D; Thakkar, N; Yadavalli, T; Yakoub, AM | 1 |
| Badolia, R; Borst, O; Campbell, RA; Kunapuli, SP; Manne, BK; Middleton, E; Münzer, P; Rondina, MT; Walker-Allgaier, B; Weyrich, AS | 1 |
| Bodewes, ILA; Dalm, VASH; Groot, N; Huijser, E; Huizinga, R; Kamphuis, S; Tas, L; van Daele, PLA; van Hagen, PM; van Helden-Meeuwsen, CG; Versnel, MA | 1 |
| Dao, LTM; Spicuglia, S | 1 |
| Bogunovic, D; Buta, S; Diaz-Griffero, F; Kim, B; Martin-Fernandez, M; Martinez-Lopez, A | 1 |
| Chang, S; Choi, EA; Choi, YS; Kim, SC; Lee, EJ; Singh, SR | 1 |
| Aakalu, VK; Ali, M; Ames, J; Iqbal, A; Koganti, R; Shukla, D; Suryawanshi, R; Yadavalli, T | 1 |
| Buseyne, F; Calzada-Fraile, D; Couteaudier, M; Gessain, A; Montange, T | 1 |
| Cho, JY; Fu, X; Jie, W; Kim, E; Li, B; Li, M; Liu, Y; Wang, Z; Xu, H; Yang, Y; Yu, T | 1 |
| Iqbal, A; Shukla, D; Suryawanshi, R; Volety, I; Yadavalli, T | 1 |
| Hopkins, J; Iqbal, A; Koganti, R; Qatanani, F; Shukla, D; Suryawanshi, R; Volety, I; Yadavalli, T | 1 |
| Chan, KK; Chung, I; Fei-Lei Chung, F; Hassan Abdul Razack, A; Hii, LW; Leong, CO; Lim, WM; Mai, CW; Nalairndran, G | 1 |
| Denson, C; Fang, Z; Gao, Y; Goswami, A; Harari-Steinfeld, R; Li, L; Marincola, FM; Pelayo, A; Qi, LS; Srivastava, R; Wang, W; Weng, L; Xiong, Q; Yang, Z | 1 |
| Gao, B; Liang, X; Lv, P; Sun, S; Yu, W; Zhang, Y | 1 |
| Campolo, M; Casili, G; Colarossi, C; Cuzzocrea, S; Esposito, E; Esposito, F; Giuffrida, D; Irene, P; Lanza, M; Scuderi, SA | 1 |
| Madavaraju, K; Qatanani, F; Shukla, D; Singh, SK; Yadavalli, T | 1 |
29 other study(ies) available for thiophenes and bx795
| Article | Year |
|---|---|
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Caco-2 Cells; Cell Membrane Permeability; Drug Design; Humans; I-kappa B Kinase; Mice; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyrimidines; Structure-Activity Relationship; Thiophenes | 2012 |
Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.
Topics: Animals; Cell Cycle Proteins; Disease Models, Animal; Endoplasmic Reticulum; Glaucoma, Open-Angle; Gliosis; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Membrane Transport Proteins; Mice; Mice, Transgenic; Protein Serine-Threonine Kinases; Pyrimidines; Retina; Thiophenes; Transcription Factor TFIIIA | 2013 |
PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Blood Platelets; Cells, Cultured; Clot Retraction; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Oncogene Protein v-akt; Phosphorylation; Platelet Activation; Pyrimidines; Receptors, Thrombin; Serine; Signal Transduction; Thiophenes; Threonine; Thromboxanes | 2014 |
Targeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma.
Topics: Apoptosis; Benzimidazoles; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Gene Knockdown Techniques; GTP Phosphohydrolases; Humans; Melanoma; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Molecular Targeted Therapy; Mutation; Neoplasm Invasiveness; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Skin Neoplasms; Thiophenes | 2014 |
Analyses of the pathways involved in early- and late-phase induction of IFN-beta during C. muridarum infection of oviduct epithelial cells.
Topics: Animals; Cell Line; Chlamydia muridarum; DNA Replication; Epithelial Cells; Female; Humans; Interferon Regulatory Factor-3; Interferon Regulatory Factor-7; Interferon-beta; NF-kappa B; Oviducts; Pyrimidines; Signal Transduction; Thiophenes; Time Factors; Toll-Like Receptor 3 | 2015 |
Type I interferon response is delayed in human astrovirus infections.
Topics: Astroviridae Infections; Caco-2 Cells; Capsid; Cell Line, Tumor; Child; Enzyme Activation; Gastroenteritis; Genotype; Humans; Interferon Type I; Mamastrovirus; Pyrimidines; RNA, Messenger; RNA, Viral; Thiophenes; Viral Nonstructural Proteins; Virus Replication | 2015 |
Virus Multiplicity of Infection Affects Type I Interferon Subtype Induction Profiles and Interferon-Stimulated Genes.
Topics: Antibodies, Neutralizing; Cell Line, Tumor; Humans; I-kappa B Proteins; Interferon-alpha; Interferon-beta; Janus Kinases; NF-kappa B; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Pyrimidines; Receptor, Interferon alpha-beta; Respirovirus Infections; Sendai virus; Signal Transduction; STAT1 Transcription Factor; Sulfones; Thiophenes; U937 Cells; Virus Replication | 2015 |
BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; I-kappa B Kinase; Mitosis; Mouth Neoplasms; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction; Thiophenes | 2015 |
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Butylamines; Caspases; Endoplasmic Reticulum Stress; Interferon Regulatory Factor-3; Macrophages; Membrane Proteins; Mice; Mitophagy; Mycobacterium bovis; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Pyrimidines; RAW 264.7 Cells; Thiophenes; Tuberculosis; X-Box Binding Protein 1 | 2016 |
BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells.
Topics: Antiviral Agents; Herpesvirus 1, Human; Herpesvirus 2, Human; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyrimidines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Thiophenes; Virus Replication | 2017 |
P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury.
Topics: Animals; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Gene Knockdown Techniques; Intraocular Pressure; Ischemia; Models, Biological; Phosphorylation; Polycomb Repressive Complex 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Retinal Ganglion Cells; RNA, Small Interfering; Signal Transduction; Thiophenes; Tumor Suppressor Protein p53; Up-Regulation | 2017 |
Brief Report: Blockade of TANK-Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)-Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells.
Topics: Blotting, Western; Child; HEK293 Cells; Humans; I-kappa B Kinase; In Vitro Techniques; Interferon Regulatory Factor-3; Interferon Regulatory Factors; Interferon-alpha; Interferon-beta; Interferon-Stimulated Gene Factor 3, gamma Subunit; Leukocytes, Mononuclear; Membrane Proteins; Mutation; Nucleotides, Cyclic; Phosphorylation; Protein Serine-Threonine Kinases; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor; Thiophenes | 2017 |
661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.
Topics: Animals; Apoptosis; Biomarkers; Cell Cycle Proteins; Cell Differentiation; Cell Line; DNA-Binding Proteins; Eye Proteins; Glaucoma; Membrane Transport Proteins; Mice; Microtubule-Associated Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neural Stem Cells; Nuclear Proteins; Pyrimidines; Retinal Ganglion Cells; Staurosporine; Thiophenes; Thy-1 Antigens; Transcription Factor Brn-3C; Tubulin | 2017 |
An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye.
Topics: Animals; Antiviral Agents; Disease Models, Animal; Enzyme Activation; Epithelium, Corneal; Eye; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice, Inbred BALB C; Proto-Oncogene Proteins c-akt; Pyrimidines; Swine; Thiophenes; Virion | 2018 |
PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Blood Platelets; Disease Models, Animal; Humans; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-raf; Pulmonary Embolism; Pyrimidines; Signal Transduction; Thiophenes; Thrombosis; Thromboxanes | 2018 |
TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis.
Topics: Adaptor Proteins, Signal Transducing; Antigens; Carrier Proteins; Cells, Cultured; Cytoskeletal Proteins; Gene Expression Regulation; Humans; Interferon Regulatory Factor-3; Interferon Regulatory Factor-7; Interferon Type I; Intracellular Signaling Peptides and Proteins; Lupus Erythematosus, Systemic; Myxovirus Resistance Proteins; Neutrophils; Phosphorylation; Protein Serine-Threonine Kinases; Pyrimidines; RNA-Binding Proteins; Scleroderma, Systemic; Signal Transduction; Sjogren's Syndrome; STAT1 Transcription Factor; Thiophenes; Toll-Like Receptor 7 | 2018 |
Transcriptional regulation by promoters with enhancer function.
Topics: Animals; CRISPR-Cas Systems; Drosophila; Enhancer Elements, Genetic; Gene Editing; Gene Expression Regulation; HeLa Cells; Humans; Indoles; Interferons; K562 Cells; Mice; Mice, Knockout; Promoter Regions, Genetic; Pyrimidines; Thiazoles; Thiophenes; Transcription, Genetic | 2018 |
SAMHD1 deficient human monocytes autonomously trigger type I interferon.
Topics: Gene Expression Regulation; Humans; Interferon Type I; Monocytes; Protein Biosynthesis; Pyrimidines; SAM Domain and HD Domain-Containing Protein 1; Small Molecule Libraries; Thiophenes; THP-1 Cells; Transcription, Genetic | 2018 |
A pharmacogenomic analysis using L1000CDS
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; Inhibitory Concentration 50; Male; Mice; Pancreatic Neoplasms; Pharmacogenomic Testing; Pyridones; Pyrimidines; Pyrimidinones; Signal Transduction; Thiophenes; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2019 |
Prior inhibition of AKT phosphorylation by BX795 can define a safer strategy to prevent herpes simplex virus-1 infection of the eye.
Topics: Animals; Cornea; Herpes Simplex; Keratitis, Herpetic; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrimidines; Thiophenes | 2020 |
Inhibitors of the interferon response increase the replication of gorilla simian foamy viruses.
Topics: Animals; Gorilla gorilla; Humans; I-kappa B Kinase; Interferon Type I; K562 Cells; Nitriles; Pyrazoles; Pyrimidines; Simian foamy virus; Thiophenes; Virus Replication | 2020 |
The kinase inhibitor BX795 suppresses the inflammatory response via multiple kinases.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Pyrimidines; RAW 264.7 Cells; Thiophenes | 2020 |
BX795 demonstrates potent antiviral benefits against herpes simplex Virus-1 infection of human cell lines.
Topics: Antiviral Agents; Cell Line; Cytokines; HEK293 Cells; HeLa Cells; Herpes Simplex; Herpesvirus 1, Human; Humans; Pyrimidines; Thiophenes | 2020 |
Topics: Acyclovir; Animals; Antiviral Agents; Female; Genitalia; Herpes Genitalis; Herpes Simplex; Herpesvirus 2, Human; Mice; Pyrimidines; Thiophenes | 2020 |
Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Cell Death; Cell Line, Tumor; Cell Survival; Docetaxel; Gene Library; Humans; Male; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Pyrimidines; RNA, Small Interfering; Signal Transduction; Thiophenes | 2020 |
Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795.
Topics: Clustered Regularly Interspaced Short Palindromic Repeats; Genetic Vectors; Humans; Lentivirus; Protein Serine-Threonine Kinases; Pyrimidines; Thiophenes; Transduction, Genetic | 2020 |
Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy.
Topics: Aging; Animals; Cellular Senescence; Doxorubicin; Mice; Mice, Transgenic; Mitophagy; Myocardium; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Pyrimidines; Thiophenes; Ubiquitin-Protein Ligases; Ubiquitination | 2021 |
TBK1 Inhibitor Exerts Antiproliferative Effect on Glioblastoma Multiforme Cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Glioblastoma; Humans; I-kappa B Kinase; Inflammation; NF-kappa B; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction; Thiophenes | 2021 |
Prophylactic treatment with BX795 blocks activation of AKT and its downstream targets to protect vaginal keratinocytes and vaginal epithelium from HSV-2 infection.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antiviral Agents; Cell Cycle Proteins; Female; Herpes Genitalis; Keratinocytes; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Oncogene Protein v-akt; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Thiophenes; Vagina; Virus Replication | 2021 |