thiophenes has been researched along with benzofurans in 121 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (18.18) | 18.7374 |
| 1990's | 14 (11.57) | 18.2507 |
| 2000's | 30 (24.79) | 29.6817 |
| 2010's | 51 (42.15) | 24.3611 |
| 2020's | 4 (3.31) | 2.80 |
| Authors | Studies |
|---|---|
| Albrecht, WL; Fleming, RW; Horgan, SW; Mayer, GD | 1 |
| Bauthier, J; Charlier, R; Richard, J | 1 |
| Atrens, DM; Ljungberg, T; Ungerstedt, U | 1 |
| Dann, O; Geratz, JD; Loewe, H; Tidwell, RR; Volz, G; Zeh, D | 1 |
| Görlitzer, K | 1 |
| Adolphson, RL; Cetenko, WA; Connor, DT; Kennedy, JA; Mullican, MD; Sorenson, RJ; Thueson, DO; Unangst, PC; Weikert, RJ; Wright, CD | 1 |
| Bach, MK; Brashler, JR; Burdick, MD; Ghazal, NB; Holm, MS; Schaub, RG; Toy, A; White, GJ; Yamashita, A | 1 |
| Hwang, SB; Lam, MH | 1 |
| Boyle, EA; Mangan, FR; Markwell, RE; Smith, SA; Thomson, MJ; Ward, RW; Wyman, PA | 1 |
| Cross, PE; Dickinson, RP; Parry, MJ; Randall, MJ | 2 |
| Ackerman, NA; Dunn, JP; Tomolonis, AJ | 1 |
| Chan, PS; Haug, MF; Marsico, JW; Press, JB; Tomcufcik, AS; Wright, WB | 1 |
| Overo, KF | 1 |
| Polster, P; Vaughan Williams, EM | 1 |
| Bauthier, J; Charlier, R; Delaunois, G | 1 |
| Bialy, G; Cheney, LC; Crenshaw, RR; Jeffries, AT; Luke, GM | 1 |
| Lippmann, W | 1 |
| Green, DM; Pinder, RM; Thompson, PB | 1 |
| Ikeda, N; Ishii, H; Mitsui, H; Oida, H; Otake, R | 1 |
| Kawabe, K; Shimada, K; Toyoshima, S | 1 |
| Song, WS; Xie, MH | 1 |
| Bohn, DL; Fanelli, GM; Russo, HF; Watson, LS | 1 |
| Eckhardt, SB; Ferris, RM; Maxwell, RA; Tang, FL; Woodward, EC | 1 |
| Boschelli, DH; Connor, DT; Ferin, MA; Imre, K; Khatana, SS; Kramer, JB; Lesch, ME; Okonkwo, GC; Sorenson, RJ; Wright, CD | 1 |
| Hayes, ES; Pugsley, MK; Saint, DA; Walker, MJ | 1 |
| Headley, PM; Herrero, JF | 1 |
| Rainsford, KD; Smith, F; Ying, C | 1 |
| Gibson, DT; Resnick, SM | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Kleven, MS; Koek, W | 1 |
| Hughes, J; Hunter, JC; Moreton, JE; Robles, L; Rose, J; Tortella, FC | 1 |
| DeCoster, MA; Tortella, FC | 1 |
| Carlsen, L; Lassen, P | 1 |
| Holtzman, SG; Powell, KR | 1 |
| Duval, C; Galey, JB; Lagrange, A; Philippe, M; Régnier, M; Schmidt, R; Tuloup, R | 1 |
| Adebayo, FO; Katz, A; Malamas, MS; McDevitt, R; Moxham, C; Sawicki, DR; Seestaller, L; Sredy, J; Sullivan, D; Taylor, JR; Xu, W | 1 |
| Bressler, DC; Fedorak, PM | 1 |
| Li, Z; Sawicki, DR; Seestaller, L; Sredy, J; Sullivan, D; Wrobel, J | 1 |
| Bergman, J; Carey, GJ | 1 |
| Furukawa, K; Goto, M; Suenaga, H | 1 |
| McGovern, DG; McKinney, R; Norton, SB; Pruell, RJ; Taplin, BK | 1 |
| Hellou, J; Meade, JD; Patel, TR | 1 |
| Kresge, AJ; Meng, Q | 1 |
| Kelliher, P; Kelly, JP; Leonard, BE; Sánchez, C | 1 |
| Finster, KW; Jensen, AM; Karlson, U | 1 |
| Henry, AA; Matsuda, S; Romesberg, FE; Schultz, PG | 1 |
| Rovner, ES; Wein, AJ | 1 |
| Oyaizu, H; Yagi, O; Yamazoe, A | 1 |
| Camp, VM; Goodman, MM; Kilts, CD; Malveaux, EJ; McConathy, J; Nemeroff, CB; Owens, MJ; Votaw, JR | 1 |
| Hsieh, M; Kershen, RT | 1 |
| Baraldi, PG; Borgatti, M; Carrion, MD; Gambari, R; Heilmann, J; Iaconinoto, MA; Romagnoli, R; Tabrizi, MA | 1 |
| Katona, A; Paizs, C; Rétey, J | 1 |
| Ballesteros, A; Barluenga, J; González, JM; Merino, I; Vázquez-Villa, H | 1 |
| Alloatti, D; Baruchello, R; Bucci, F; Carminati, P; Castorina, M; Giannini, G; Guglielmi, MB; Marcellini, M; Pavani, MG; Pisano, C; Riccioni, T; Rizzi, M; Romagnoli, R; Rondanin, R; Simoni, D | 1 |
| Li, F; Ma, C; Qu, J; Wang, Y; Xu, P; Yu, B; Zhou, W; Zhu, S | 1 |
| Hosomi, M; Kishita, S; Nakai, S; Nomura, Y | 1 |
| Linden, KG; Shemer, H | 1 |
| Cardozo, L; Cartwright, R; Robinson, D; Vella, M | 1 |
| Deng, Z; Feng, J; Gai, Z; Li, L; Ma, C; Wang, Y; Xu, P; Yu, B | 1 |
| Bratton, L; Cheng, XM; Erasga, N; Filzen, GF; Geyer, A; Lee, C; Lu, G; Pulaski, J; Sorenson, RJ; Trivedi, BK; Unangst, PC; Xu, X | 1 |
| Cai, H; Edwards, JP; Gu, Y; Jiang, W; Karlsson, L; Meduna, SP; Pio, BA; Sun, S; Thurmond, RL; Wei, J | 1 |
| Hosomi, M; Kishita, S; Nakai, S; Takada, M; Yamada, S | 1 |
| Lautens, M; Tseng, NW | 1 |
| Aurell, J; Fick, J; Haglund, P; Marklund, S | 1 |
| Aureggi, V; Bryan, CS; Lautens, M; Newman, SG | 1 |
| Jilma, B; Krumphuber, J; Siller-Matula, JM | 1 |
| Guo, HF; He, XB; Jiang, JD; Li, X; Li, ZR; Liu, ZY; Shao, HY; Si, SY; Xue, ST; Yang, ZY; Zhang, YQ | 1 |
| Babic, S; Calvin, W; Cui, J; Luedtke, RR; Mach, RH; Taylor, M; Vangveravong, S; Xu, J | 1 |
| Aggarwal, S; Bhardwaj, TR; Kumar, M; Thareja, S | 1 |
| Braun, M; Fischer, A; Frank, W; Grittner, D; Lachenicht, S; Lemoine, H; Rood, A; Schmidt, C; Winkler, M; Wrobel, T | 1 |
| Lowary, TL; Marcus, SL; Shi, W | 1 |
| Lowary, TL; Shi, W | 1 |
| Ljubić, I; Sabljić, A | 1 |
| Jang, YJ; Lee, YT; Lin, W; Syu, SE | 1 |
| Drummond, E; Fisher, KE; Gorczyca, RR; Grimwood, S; Hajos, M; Horner, WE; Johnson, DE; McDowell, LL; Miller, E; Nelson, RT; Rubitski, DM; Sawant-Basak, A; Siok, CJ; Stutzman-Engwall, KJ; Tseng, E; Vanase-Frawley, MA | 1 |
| Anjana Devi, T; Jain, N; Kalivendi, SV; Kantevari, S; Murthy, R; Patpi, SR; Pulipati, L; Sridhar, B; Sriram, D; Yogeeswari, P | 1 |
| Hashmi, AS; Rominger, F; Yang, W | 1 |
| Chen, W; Wang, L; Zhou, W | 1 |
| Chou, SC; Jang, YJ; Lee, CJ; Lee, YT; Lin, W; Syu, SE | 1 |
| Ciepielski, J; de Pascual-Teresa, B; de Pascual-Teresa, S; Demkowicz, S; Filipiak, K; Martín-Santamaría, S; Maslyk, M; Ramos, A; Rodríguez, JJ | 1 |
| Allen, CC; Boyd, DR; Brannigan, IN; Evans, TA; Haughey, SA; Malone, JF; McIntyre, PB; McMurray, BT; Sharma, ND; Stevenson, PJ | 1 |
| Abdayem, R; Barret, R; Colomb, E; Dubois, J; Guillaume, J; Haftek, M; Lomberget, T; Nachtergaele, L; Nguyen, TT; Thoret, S; Tran, NC | 1 |
| Chen, W; Li, P; Meng, LG; Miao, T; Wang, L | 1 |
| Davies, L; Marais, R; Ménard, D; Niculescu-Duvaz, D; Niculescu-Duvaz, I; Pons, JF; Springer, CJ; Suijkerbuijk, BM; Whittaker, S; Zambon, A | 1 |
| Beall, HD; Bibby, JM; Hassani, M; Moody, CJ; Newsome, JJ; Swann, E | 1 |
| Cho, HY; Hwang, GT; Lee, J | 1 |
| Anxionnat, B; Cossy, J; Gomez Pardo, D; Ricci, G; Rossen, K | 1 |
| Bandholtz, S; Goebel, M; Gust, R; Herbst, L; Kintscher, U | 1 |
| Chang, YS; Jeon, JR; Le, TT; Murugesan, K; Nam, IH | 1 |
| Fan, C; Sheng, J; Wu, J | 1 |
| Ma, F; Qu, Y; Shi, S; Zhou, J | 2 |
| Chen, PQ; Chen, YC; Xiao, YC; Yue, CZ | 1 |
| Parachikova, AI; Pedersen, CS; Plath, N; Sørensen, DB | 1 |
| Gharpure, SJ; Prasath, V | 1 |
| Douglas, MW; Eltahla, AA; Tay, E; White, PA | 1 |
| Brignone, M; Ereshefsky, L; Francois, C; Lançon, C; Llorca, PM; Rive, B; Salah, S | 1 |
| Dodda, RP; Haque, R; Jadiya, P; Kumar, M; Kumar, V; Modukuri, RK; Nazir, A; Sashidhara, KV; Siddiqi, MI; Sridhar, B | 1 |
| Bartoli, S; Berettoni, M; Bigioni, M; Binaschi, M; Cipollone, A; Ettorre, A; Fattori, D; Fincham, CI; Maggi, CA; Marastoni, E; Mauro, S; Nardelli, F; Paoli, P; Paris, M; Parlani, M; Porcelloni, M; Rossi, P | 1 |
| Guo, HF; Jin, J; Ju, DH; Li, ZR; Liu, MJ; Liu, ZY; Xue, ST | 1 |
| Ben Ammar, H; Ben Hassine, B; Doucet, H; Hfaiedh, A; Soulé, JF; Yuan, K | 1 |
| Crooks, PA; Penthala, NR; Thakkar, S | 1 |
| Kibble, A | 1 |
| Ihara, M; Iikuni, S; Kimura, H; Kitada, A; Matsumura, K; Okamoto, Y; Ono, M; Saji, H; Watanabe, H; Yoshimura, M | 1 |
| Browne, KA; Ciccone, A; Denny, WA; Huttunen, KM; Jaiswal, JK; Miller, CK; Spicer, JA; Trapani, JA | 1 |
| Desantis, J; Goracci, L; Massari, S; Tabarrini, O | 1 |
| Jiang, B; Ning, S; Shi, S; Tan, L | 1 |
| Oberoi, AS; Philip, L | 1 |
| Chen, C; Huang, Q; Li, H; Long, YQ; Wang, HY; Xu, B | 1 |
| El-Hawash, SAM; El-Messmary, H; El-Miligy, MMM; Hazzaa, AA; Nassra, RA | 1 |
| Gao, F; Gao, Y; Liu, LL; Ma, N; Wang, JT; Xia, W; Yang, C | 1 |
| Ji, X; Li, N; Ning, S; Shi, S; Tan, L; Xu, J | 1 |
| Kantevari, S; Marvadi, SK; Sriram, D; Surineni, G; Yogeeswari, P | 1 |
| Marimuthu, P; Singaravelu, K | 1 |
| Afridi, S; Amjad, ST; Anbar, HS; El-Gamal, MI; El-Gamal, R; Iqbal, J; Shafique, Z; Zaib, S; Zaraei, SO | 1 |
| Gao, Y; Li, X; Sun, Y; Xu, F; Zhang, Q; Zheng, S; Zuo, C | 1 |
| Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L | 1 |
| Bräuer, J; Dao-Huy, T; Dirsch, VM; Latkolik, S; Mihovilovic, MD; Pfeil, A; Schnürch, M; Stuppner, H | 1 |
| Al-Rashida, M; Anbar, HS; El-Gamal, MI; El-Gamal, R; Iqbal, J; Pelletier, J; Sévigny, J; Ullah, S; Zaib, S; Zaraei, SO | 1 |
| Betz, K; Diederichs, K; Ghosh, P; Kropp, HM; Ludmann, S; Marx, A; Srivatsan, SG | 1 |
9 review(s) available for thiophenes and benzofurans
| Article | Year |
|---|---|
Kappa opioids: therapeutic considerations in epilepsy and CNS injury.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Benzofurans; Central Nervous System Diseases; Epilepsy; Humans; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Thiophenes | 1994 |
Bacterial metabolism of fluorene, dibenzofuran, dibenzothiophene, and carbazole.
Topics: Bacteria; Benzofurans; Biodegradation, Environmental; Carbazoles; Fluorenes; Thiophenes | 2000 |
Update on overactive bladder: pharmacologic approaches on the horizon.
Topics: Administration, Cutaneous; Administration, Intravesical; Administration, Oral; Adrenergic beta-3 Receptor Antagonists; Benzhydryl Compounds; Benzilates; Benzofurans; Botulinum Toxins; Cresols; Dosage Forms; Dose-Response Relationship, Drug; Drug Compounding; Drug Evaluation; Duloxetine Hydrochloride; Humans; Mandelic Acids; Muscarinic Antagonists; Nortropanes; Phenylpropanolamine; Pyrrolidines; Thiophenes; Tolterodine Tartrate; Treatment Outcome; Urinary Bladder Diseases; Urination Disorders | 2003 |
Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine.
Topics: Benzilates; Benzofurans; Clinical Trials as Topic; Duloxetine Hydrochloride; Humans; Muscarinic Antagonists; Nortropanes; Pyrrolidines; Quinuclidines; Selective Serotonin Reuptake Inhibitors; Solifenacin Succinate; Tetrahydroisoquinolines; Thiophenes; Urinary Incontinence | 2004 |
New developments in the treatment of urinary incontinence.
Topics: Administration, Cutaneous; Adrenergic Uptake Inhibitors; Benzofurans; Drug Therapy, Combination; Duloxetine Hydrochloride; Humans; Mandelic Acids; Muscarinic Antagonists; Pyrrolidines; Quality of Life; Quinuclidines; Solifenacin Succinate; Tetrahydroisoquinolines; Thiophenes; Treatment Outcome; Urinary Bladder, Overactive; Urinary Incontinence, Stress | 2006 |
Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases.
Topics: Adenosine; Adenosine Monophosphate; Benzofurans; Blood Platelets; Carbamates; Clinical Trials as Topic; Clopidogrel; Humans; Lactones; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Receptor, PAR-1; Receptors, Proteinase-Activated; Thiophenes; Ticagrelor; Ticlopidine; von Willebrand Factor | 2010 |
Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus.
Topics: Acetophenones; Amino Acid Sequence; Animals; Benzoates; Benzofurans; Biphenyl Compounds; Blood Glucose; Catalytic Domain; Catechols; Chromones; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fluorides; Humans; Insulin; Insulin Resistance; Insulin Secretion; Janus Kinase 2; Models, Molecular; Naphthoquinones; Peptidomimetics; Phosphates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyridazines; Receptor, Insulin; Signal Transduction; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Thiophenes; Vanadium Compounds | 2012 |
Relative efficacy and tolerability of vortioxetine versus selected antidepressants by indirect comparisons of similar clinical studies.
Topics: Acetamides; Adult; Aged; Antidepressive Agents; Benzofurans; Citalopram; Cyclohexanols; Depressive Disorder, Major; Desvenlafaxine Succinate; Duloxetine Hydrochloride; Female; Humans; Hypnotics and Sedatives; Indoles; Male; Middle Aged; Piperazines; Selective Serotonin Reuptake Inhibitors; Sertraline; Sulfides; Thiophenes; Venlafaxine Hydrochloride; Vilazodone Hydrochloride; Vortioxetine | 2014 |
Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Protein-Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics.
Topics: Animals; Antiviral Agents; Benzofurans; Drug Resistance, Viral; Humans; Multiprotein Complexes; Orthomyxoviridae; Peptides; Pyrazoles; Pyridines; Pyrimidines; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Thiazoles; Thiophenes; Viral Proteins | 2016 |
112 other study(ies) available for thiophenes and benzofurans
| Article | Year |
|---|---|
Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene.
Topics: Animals; Antiviral Agents; Benzofurans; Carbazoles; Encephalomyocarditis virus; Enterovirus Infections; Herpes Simplex; Male; Methods; Mice; Mice, Nude; Simplexvirus; Structure-Activity Relationship; Thiophenes | 1977 |
A potentially antianginal benzo [b]thiophene with an amiodarone-like haemodynamic profile.
Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Animals; Benzofurans; Blood Pressure; Cardiac Output; Coronary Circulation; Depression, Chemical; Dogs; Electrocardiography; Epinephrine; Female; Heart Rate; Hemodynamics; Hypertension; Isoproterenol; Male; Oxygen Consumption; Propylamines; Tachycardia; Thiophenes; Vascular Resistance | 1975 |
Specific inhibition of hypothalamic self-stimulation by selective reuptake blockade of either 5-hydroxytryptamine or noradrenaline.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds; Depression, Chemical; Electrodes, Implanted; Hypothalamus; Male; Norepinephrine; Rats; Self Stimulation; Serotonin; Thiophenes | 1977 |
Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases.
Topics: Amidines; Anticoagulants; Benzimidazoles; Benzofurans; Blood Coagulation Tests; Humans; Indoles; Kallikreins; Protease Inhibitors; Structure-Activity Relationship; Thiophenes; Thrombin; Thromboplastin; Time Factors; Trypsin Inhibitors | 1978 |
[Studies on 1.3-dicarbonyl compounds. 6. Anellated quinolones].
Topics: Benzofurans; Chemical Phenomena; Chemistry; Cyclization; ortho-Aminobenzoates; Quinolines; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiophenes | 1976 |
Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents.
Topics: Antibodies, Anti-Idiotypic; Basophils; Benzofurans; Eosinophils; Histamine Antagonists; Histamine Release; Humans; Hypersensitivity; Immunoglobulin E; Lung; Molecular Structure; Naphthalenes; Neutrophils; Respiratory Burst; Structure-Activity Relationship; Tetrazoles; Thiophenes | 1992 |
1,4-Dihydronaphthoquinones, hydroindoloquinones, benzofurans, and benzothiophenes as inhibitors of 5-lipoxygenase. Synthesis and structure-activity studies.
Topics: Animals; Arachidonate Lipoxygenases; Benzofurans; Chemical Phenomena; Chemistry; Chemistry, Physical; Enzyme Inhibitors; In Vitro Techniques; Indoles; Leukocytes, Mononuclear; Leukotriene B4; Lipoxygenase Inhibitors; Naphthoquinones; Quinones; Rats; SRS-A; Structure-Activity Relationship; Thiophenes | 1990 |
Species difference in the specific receptors of platelet activating factor.
Topics: Animals; Benzofurans; Blood Platelets; Cell Membrane; Diterpenes; Furans; Ginkgolides; Humans; Lactones; Lignans; Lung; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Thiophenes | 1986 |
7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents.
Topics: Analgesics; Animals; Benzofurans; Cyclooxygenase Inhibitors; Gastric Mucosa; Male; Mice; Structure-Activity Relationship; Thiophenes; Tolmetin | 1986 |
Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene.
Topics: Animals; Benzofurans; Carboxylic Acids; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Epoprostenol; Imidazoles; Indoles; Intramolecular Oxidoreductases; Male; Naphthalenes; Rats; Steroid 11-beta-Hydroxylase; Thiophenes; Thromboxane-A Synthase | 1986 |
Analgetic and antiinflammatory 7-aroylbenzofuran-5-ylacetic acids and 7-aroylbenzothiophene-5-ylacetic acids.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Female; Male; Mice; Rats; Structure-Activity Relationship; Thiophenes | 1986 |
Thromboxane synthetase inhibitors and antihypertensive agents. 3. N-[(1H-imidazol-1-yl)alkyl]heteroaryl amides as potent enzyme inhibitors.
Topics: Amides; Animals; Antihypertensive Agents; Benzofurans; Furans; Guinea Pigs; Heterocyclic Compounds; Imidazoles; Indoles; Male; Pyridines; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Thiophenes; Thromboxane-A Synthase | 1987 |
Selective thromboxane synthetase inhibitors. 3. 1H-imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene-, and indole-2- and -3-carboxylic acids.
Topics: Animals; Benzofurans; Carboxylic Acids; Chemical Phenomena; Chemistry; Dogs; Imidazoles; Indoles; Male; Structure-Activity Relationship; Thiophenes; Thromboxane-A Synthase | 1986 |
Kinetics of three structurally related bicyclic antidepressant compounds--a comparison in the dog.
Topics: Animals; Antidepressive Agents; Benzofurans; Biotransformation; Dogs; Half-Life; Indenes; Kinetics; Male; Metabolic Clearance Rate; Methylamines; Propylamines; Protein Binding; Structure-Activity Relationship; Thiophenes | 1973 |
The effect of cardiac muscle of two drugs related to amiodarone, L8040 and L8462.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzoates; Benzofurans; Body Weight; Electric Stimulation; Electrocardiography; Female; Growth; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Iodobenzoates; Male; Organ Size; Ouabain; Propylamines; Rabbits; Refractory Period, Electrophysiological; Thiophenes; Time Factors; Ventricular Fibrillation | 1974 |
[Pharmacologic profile of a new non-competitive antiadrenergic agent with an anti-angina potential--a derivative of amiodarone].
Topics: Angina Pectoris; Animals; Anti-Arrhythmia Agents; Benzoates; Benzofurans; Blood Flow Velocity; Blood Pressure; Cardiac Output; Dogs; Ethylamines; Heart Rate; Hypertension; Iodobenzoates; Oxygen Consumption; Propylamines; Tachycardia; Thiophenes; Time Factors | 1973 |
Potential antifertility agents. 1. Substituted diaryl derivatives of benzo[b]thiophenes, benzo[b]furans, 1H-2-benzothiapyrans, and 2H-1-benzothiapyrans.
Topics: Animals; Anticholesteremic Agents; Benzofurans; Benzopyrans; Cholesterol; Contraceptives, Oral; Estrogen Antagonists; Female; Gonadotropins; Male; Mice; Organ Size; Prostate; Rats; Seminal Vesicles; Sulfur; Testis; Thiophenes; Time Factors; Uterus | 1971 |
Potentiation of ocular response to adrenaline by 3,3-dimethyl-1-(3-methylaminopropyl)-1-phenylphthalan (Lu 3-010) and a thiophthalan analogue (Lu 5-003): blockers of catecholamine uptake.
Topics: Animals; Benzofurans; Catecholamines; Dibenzocycloheptenes; Drug Synergism; Epinephrine; Female; Methylamines; Phenoxybenzamine; Pupil; Rabbits; Thiophenes; Time Factors | 1971 |
Comparative pharmacology of 5-hydroxytryptamine and tis benzofuran, benzo(b)thiophen, and indene isosteres.
Topics: Animals; Benzofurans; Binding Sites; Body Temperature; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indenes; Male; Muscle Contraction; Phenoxybenzamine; Receptors, Drug; Serotonin; Serotonin Antagonists; Stomach; Structure-Activity Relationship; Thiophenes | 1971 |
[The orientation of oxidation of 7-hydroxy-2,3-diphenylbenzofuran and-benzo [b]-thiophene with Fremy's salt. The studies on the heterocyclic quinones. II].
Topics: Benzofurans; Chemical Phenomena; Chemistry; Nitroso Compounds; Oxidation-Reduction; Potassium; Salts; Spectrum Analysis; Sulfites; Thiophenes | 1970 |
[Studies on chemotherapeutic drugs. IV. Synthesis of nitrofuran derivatives. (3). Preparation of 2-(5-nitro-2-furfurylidene)-3-oxo-2,3-dihydrobenzofuran (or thiophene) derivatives and their antibacterial activities].
Topics: Anti-Bacterial Agents; Benzofurans; Furaldehyde; Nitrobenzenes; Resorcinols; Thiophenes | 1968 |
[Antihypertensive drugs: synthesis of quaternary ammonium salts and guanidine derivatives of thiophene, furan and benzofuran (author's transl)].
Topics: Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Furans; Guanidines; Quaternary Ammonium Compounds; Rats; Thiophenes | 1982 |
Diuretic and uricosuric activity of 6,7-dichloro-2,3-dihydro-5-(2-thienylcarbonyl)benzofuran-2-carboxylic acid and stereoisomers in chimpanzee, dog and rat.
Topics: Animals; Benzofurans; Chemical Phenomena; Chemistry; Diuretics; Dogs; Female; Male; Pan troglodytes; Rats; Species Specificity; Stereoisomerism; Thiophenes; Uricosuric Agents | 1980 |
Structure-activity relationships for potent phthalane and thiophthalane inhibitors of norepinephrine uptake. A comparison with desipramine and related compounds.
Topics: Animals; Antidepressive Agents; Benzofurans; Desipramine; Hypothalamus; In Vitro Techniques; Kinetics; Male; Myocardial Contraction; Norepinephrine; Rabbits; Rats; Stereoisomerism; Structure-Activity Relationship; Sympathetic Nervous System; Synaptosomes; Thiophenes | 1980 |
Inhibition of E-selectin-, ICAM-1-, and VCAM-1-mediated cell adhesion by benzo[b]thiophene-, benzofuran-, indole-, and naphthalene-2-carboxamides: identification of PD 144795 as an antiinflammatory agent.
Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Endothelium, Vascular; Humans; Indoles; Intercellular Adhesion Molecule-1; Magnetic Resonance Spectroscopy; Mice; Naphthalenes; Neutrophils; Thiophenes; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 1995 |
Do related kappa agonists produce similar effects on cardiac ion channels?
Topics: Animals; Anti-Arrhythmia Agents; Benzofurans; Blood Pressure; Electric Stimulation; Electrocardiography; Heart; Heart Rate; Heart Ventricles; Ion Channels; Male; Myocardium; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereoisomerism; Thiophenes | 1995 |
Functional evidence for multiple receptor activation by kappa-ligands in the inhibition of spinal nociceptive reflexes in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Benzeneacetamides; Benzofurans; Blood Pressure; Decerebrate State; Male; Naloxone; Nociceptors; Piperazines; Pyrroles; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord; Thiophenes | 1993 |
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
Topics: Animals; Benzofurans; Enzyme-Linked Immunosorbent Assay; Hip Joint; Humans; Hydroxyurea; Indoles; Interleukin-1; Knee Joint; Lipoxygenase Inhibitors; Naphthalenes; Organ Culture Techniques; Oxindoles; Pyrazoles; Quinolines; Structure-Activity Relationship; Swine; Synovial Membrane; Tarsus, Animal; Thiazoles; Thiophenes | 1996 |
Regio- and stereospecific oxidation of fluorene, dibenzofuran, and dibenzothiophene by naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4.
Topics: Benzofurans; Biotransformation; Dioxygenases; Escherichia coli; Fluorenes; Magnetic Resonance Spectroscopy; Multienzyme Complexes; Mutation; Oxidation-Reduction; Oxygenases; Pseudomonas; Recombination, Genetic; Stereoisomerism; Substrate Specificity; Thiophenes | 1996 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Discriminative stimulus properties of cocaine: enhancement by beta-adrenergic receptor antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Benzofurans; Betaxolol; Brimonidine Tartrate; Cocaine; Discrimination Learning; Discrimination, Psychological; Drug Synergism; Imidazoles; Male; Nadolol; Narcotics; Propanolamines; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Thiophenes | 1997 |
EEG spectral analysis of the neuroprotective kappa opioids enadoline and PD117302.
Topics: Animals; Benzofurans; Electroencephalography; Male; Narcotics; Neuroprotective Agents; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Thiophenes | 1997 |
The effect of humic acids on the water solubility and water-organic carbon partitioning of fluorene and its NSO-heteroanalogues: carbazole, dibenzofuran, and dibenzothiophene.
Topics: Benzofurans; Carbazoles; Carbon; Chemical Phenomena; Chemistry, Physical; Fluorenes; Fresh Water; Humic Substances; Solubility; Thiophenes; Water Supply | 1999 |
Differential antagonism of the rate-decreasing effects of kappa-opioid receptor agonists by naltrexone and norbinaltorphimine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzofurans; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Ethylketocyclazocine; Nalorphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Reinforcement Schedule; Saimiri; Thiophenes | 1999 |
Keratinocyte-melanocyte co-cultures and pigmented reconstructed human epidermis: models to study modulation of melanogenesis.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Arbutin; Asian People; Benzofurans; Black People; Cells, Cultured; Coculture Techniques; Culture Media; Epidermal Cells; Ethnicity; Humans; Hydroquinones; Hydroxybenzoates; Indoles; Keratinocytes; Melanins; Melanocytes; Mice; Phenotype; Pyrones; Skin Pigmentation; Skin, Artificial; Theophylline; Thiophenes; Ultraviolet Rays; White People | 1999 |
Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.
Topics: Administration, Oral; Animals; Benzofurans; Blood Glucose; Catalytic Domain; Crystallography, X-Ray; Diabetes Mellitus; Enzyme Inhibitors; Humans; Hydrogen Bonding; Hypoglycemic Agents; Mice; Models, Molecular; Phenylpropionates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Structure-Activity Relationship; Thiophenes | 2000 |
Synthesis and PTP1B inhibition of novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes.
Topics: Amino Acid Sequence; Animals; Benzofurans; Binding Sites; Drug Design; Enzyme Inhibitors; Indicators and Reagents; Mice; Models, Molecular; Molecular Conformation; Oligopeptides; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Structure-Activity Relationship; Substrate Specificity; Thiophenes | 2000 |
Enadoline discrimination in squirrel monkeys: effects of opioid agonists and antagonists.
Topics: Animals; Benzofurans; Discrimination Learning; Dose-Response Relationship, Drug; Male; Nalbuphine; Naltrexone; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Thiophenes | 2001 |
Emergence of multifunctional oxygenase activities by random priming recombination.
Topics: Base Sequence; Benzofurans; Cloning, Molecular; Dioxins; DNA Primers; Fluorenes; Gas Chromatography-Mass Spectrometry; Mutagenesis, Site-Directed; Oxygenases; Polychlorinated Biphenyls; Pseudomonas; Recombination, Genetic; Thiophenes | 2001 |
Organic contaminant distributions in sediments, polychaetes (Nereis virens) and American lobster (Homarus americanus) from a laboratory food chain experiment.
Topics: Animals; Benzofurans; Dibenzofurans, Polychlorinated; Food Chain; Geologic Sediments; Nephropidae; Polychaeta; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Soil Pollutants; Thiophenes | 2000 |
Aerobic co-metabolism of sulfur, nitrogen and oxygen heterocycles by three marine bacterial consortia.
Topics: Aerobiosis; Benzofurans; Biodegradation, Environmental; Carbazoles; Ecosystem; Gas Chromatography-Mass Spectrometry; Gram-Negative Bacteria; Heterocyclic Compounds; Newfoundland and Labrador; Nitrogen; Oxygen; Seawater; Spectroscopy, Fourier Transform Infrared; Sulfur; Thiophenes | 2002 |
Comparison of oxygen and sulfur effects on keto-enol chemistry in benzolactone systems: benzo[b]-2,3-dihydrofuran-2-one and -2-thione and benzo[b]-2,3-dihydrothiophene-2-one and -2-thione.
Topics: Benzofurans; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Lactones; Oxygen; Sodium Hydroxide; Spectrophotometry, Ultraviolet; Sulfur; Thiophenes | 2002 |
Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Benzofurans; Butylamines; Corticosterone; Drug Administration Schedule; Drug Evaluation, Preclinical; Escape Reaction; Hypokinesia; Male; Pituitary Gland, Anterior; Pro-Opiomelanocortin; Rats; Rats, Wistar; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Swimming; Thiophenes | 2003 |
Degradation of carbazole, dibenzothiophene, and dibenzofuran at low temperature by Pseudomonas sp. strain C3211.
Topics: Benzofurans; Biodegradation, Environmental; Carbazoles; Carcinogens; Molecular Structure; Pseudomonas; Temperature; Thiophenes; Time Factors | 2003 |
The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs.
Topics: Base Pairing; Benzofurans; Circular Dichroism; DNA; Hydrogen Bonding; Indoles; Kinetics; Nucleotides; Thiophenes; Triazoles | 2003 |
Degradation of polycyclic aromatic hydrocarbons by a newly isolated dibenzofuran-utilizing Janibacter sp. strain YY-1.
Topics: Actinomycetales; Benzofurans; Fluorenes; Phylogeny; Polycyclic Aromatic Hydrocarbons; Thiophenes | 2004 |
Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter.
Topics: Alkylation; Animals; Benzofurans; Binding, Competitive; Chromatography, High Pressure Liquid; Dopamine Plasma Membrane Transport Proteins; Indicators and Reagents; Ligands; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Positron-Emission Tomography; Propylamines; Radiopharmaceuticals; Serotonin Plasma Membrane Transport Proteins; Spectrophotometry, Ultraviolet; Stereoisomerism; Symporters; Thiophenes; Tissue Distribution | 2004 |
Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzofurans; Drug Screening Assays, Antitumor; Heterocyclic Compounds; Humans; Imidazoles; Mice; Molecular Structure; Netropsin; Pyrazoles; Pyrroles; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured | 2005 |
The interaction of heteroaryl-acrylates and alanines with phenylalanine ammonia-lyase from parsley.
Topics: Acrylates; Alanine; Benzofurans; Catalysis; Drug Interactions; Furans; Petroselinum; Phenylalanine Ammonia-Lyase; Spectrum Analysis; Substrate Specificity; Thiophenes | 2006 |
The reaction of o-alkynylarene and heteroarene carboxaldehyde derivatives with iodonium ions and nucleophiles: a versatile and regioselective synthesis of 1H-isochromene, naphthalene, indole, benzofuran, and benzothiophene compounds.
Topics: Aldehydes; Alkynes; Benzofurans; Benzopyrans; Heterocyclic Compounds; Indoles; Ions; Naphthalenes; Onium Compounds; Pyridines; Thiophenes | 2006 |
Novel combretastatin analogues endowed with antitumor activity.
Topics: Animals; Antineoplastic Agents; Benzofurans; Bibenzyls; Binding, Competitive; Biopolymers; Cell Line, Tumor; Cell Nucleus; Colchicine; Endothelial Cells; Endothelium, Vascular; Female; Humans; Mice; Mice, Nude; Microtubules; Organophosphates; Prodrugs; Stereoisomerism; Stilbenes; Structure-Activity Relationship; Thiophenes; Tubulin; Xenograft Model Antitumor Assays | 2006 |
Simultaneous biodetoxification of S, N, and O pollutants by engineering of a carbazole-degrading gene cassette in a recombinant biocatalyst.
Topics: Benzofurans; Biodegradation, Environmental; Carbazoles; Environmental Pollutants; Genetic Engineering; Nitrogen; Oxygen; Recombination, Genetic; Rhodococcus; Sulfur; Thiophenes | 2006 |
Polychlorinated dibenzothiophenes in Japanese environmental samples and their photodegradability and dioxin-like endocrine-disruption potential.
Topics: Benzofurans; Biodegradation, Environmental; Dibenzofurans, Polychlorinated; Endocrine System Diseases; Environmental Exposure; Environmental Pollutants; Immunoassay; Isomerism; Japan; Photochemistry; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Risk Assessment; Thiophenes; Time Factors | 2007 |
Aqueous photodegradation and toxicity of the polycyclic aromatic hydrocarbons fluorene, dibenzofuran, and dibenzothiophene.
Topics: Aliivibrio fischeri; Benzofurans; Carcinogens; Chromatography, High Pressure Liquid; Fluorenes; Hydrogen Peroxide; Kinetics; Luminescent Measurements; Photolysis; Polycyclic Aromatic Hydrocarbons; Thiophenes; Ultraviolet Rays; Water Pollutants, Chemical | 2007 |
Cometabolic degradation of dibenzofuran and dibenzothiophene by a newly isolated carbazole-degrading Sphingomonas sp. strain.
Topics: Base Sequence; Benzofurans; Biodegradation, Environmental; Carbazoles; Chromatography, High Pressure Liquid; Environmental Pollutants; Mass Spectrometry; Molecular Sequence Data; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Spectrophotometry, Ultraviolet; Sphingomonas; Thiophenes | 2007 |
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Topics: Animals; Benzofurans; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Humans; Indoles; Inhibitory Concentration 50; Ligands; Models, Chemical; PPAR delta; Structure-Activity Relationship; Thiazoles; Thiophenes | 2007 |
Pyrazole-based cathepsin S inhibitors with improved cellular potency.
Topics: Animals; Aza Compounds; Benzofurans; Carboxylic Acids; Cathepsins; Humans; Indoles; Molecular Structure; Protease Inhibitors; Pyrazoles; Structure-Activity Relationship; Thiophenes | 2007 |
Photodechlorination of octachlorodibenzothiophene and octachlorodibenzofuran: comparison of experimental degradation pathways with degradation pathways predicted by DFT.
Topics: Benzofurans; Models, Chemical; Models, Molecular; Molecular Structure; Photolysis; Thiophenes | 2008 |
Application of a rhodium-catalyzed addition/cyclization sequence toward the synthesis of polycyclic heteroaromatics.
Topics: Alkenes; Benzofurans; Boronic Acids; Catalysis; Cyclization; Esters; Heterocyclic Compounds; Indoles; Polycyclic Compounds; Rhodium; Thiophenes | 2009 |
Effects of sulfur on PCDD/F formation under stable and transient combustion conditions during MSW incineration.
Topics: Air Pollutants; Benzofurans; Dibenzofurans, Polychlorinated; Hot Temperature; Hydrochloric Acid; Incineration; Polychlorinated Dibenzodioxins; Refuse Disposal; Sulfur Dioxide; Thiophenes | 2009 |
Intramolecular cross-coupling of gem-dibromoolefins: a mild approach to 2-bromo benzofused heterocycles.
Topics: Alkenes; Benzofurans; Catalysis; Copper; Halogenation; Thiophenes | 2009 |
Substituted benzothiophene or benzofuran derivatives as a novel class of bone morphogenetic protein-2 up-regulators: synthesis, structure-activity relationships, and preventive bone loss efficacies in senescence accelerated mice (SAMP6) and ovariectomized
Topics: Anabolic Agents; Animals; Benzofurans; Bone Density; Bone Density Conservation Agents; Bone Morphogenetic Protein 2; Cell Line; Female; Lethal Dose 50; Male; Mice; Osteoporosis; Ovariectomy; Rats; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Up-Regulation | 2010 |
Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.
Topics: Adenylyl Cyclases; Benzofurans; Cell Line; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Indoles; Protein Binding; Receptors, Dopamine D2; Thiophenes | 2010 |
Synthesis of benzofuran, benzothiophene, and benzothiazole-based thioamides and their evaluation as K(ATP) channel openers.
Topics: Animals; Benzofurans; Benzothiazoles; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; HEK293 Cells; Humans; KATP Channels; Molecular Conformation; Potassium Channels, Inwardly Rectifying; Structure-Activity Relationship; Thioamides; Thiophenes | 2010 |
Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans.
Topics: Benzofurans; Cell Line, Tumor; Drug Screening Assays, Antitumor; Glycosylation; Humans; Indoles; Inhibitory Concentration 50; Thiophenes; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2011 |
Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans.
Topics: Amino Acids; Amino Sugars; Benzofurans; Carbohydrates; Cell Line; Cell Survival; Cytotoxins; Glycosylation; Hep G2 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Phenol; Thiophenes | 2011 |
CASSCF/CASPT2 and TD-DFT study of valence and Rydberg electronic transitions in fluorene, carbazole, dibenzofuran, and dibenzothiophene.
Topics: Benzofurans; Carbazoles; Electrons; Fluorenes; Quantum Theory; Thiophenes; Time Factors | 2011 |
Preparation of functional benzofurans, benzothiophenes, and indoles using ester, thioester, and amide via intramolecular Wittig reactions.
Topics: Aldehydes; Amides; Benzene Derivatives; Benzofurans; Esters; Indoles; Molecular Structure; Thiophenes | 2011 |
The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations.
Topics: Acetylcholine; Animals; Area Under Curve; Benzofurans; Chromatography, High Pressure Liquid; Electroencephalography; Hippocampus; Histamine; Humans; Male; Microdialysis; Prefrontal Cortex; Pyridones; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Agonists; Tandem Mass Spectrometry; Thiophenes | 2012 |
Design, synthesis, and structure-activity correlations of novel dibenzo[b,d]furan, dibenzo[b,d]thiophene, and N-methylcarbazole clubbed 1,2,3-triazoles as potent inhibitors of Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Benzofurans; Carbazoles; Cell Line, Tumor; Click Chemistry; Cytostatic Agents; Drug Design; Humans; Mycobacterium tuberculosis; Thiophenes; Triazoles | 2012 |
Gold(I)-catalyzed rearrangement of 3-silyloxy-1,5-enynes: an efficient synthesis of benzo[b]thiophenes, dibenzothiophenes, dibenzofurans, and indole derivatives.
Topics: Alkynes; Benzofurans; Catalysis; Combinatorial Chemistry Techniques; Gold; Indoles; Molecular Structure; Organosilicon Compounds; Thiophenes | 2012 |
A highly efficient one-pot reaction of 2-(gem-dibromovinyl)phenols(thiophenols) with K4Fe(CN)6 to 2-cyanobenzofurans(thiophenes).
Topics: Benzofurans; Catalysis; Ferrocyanides; Magnetic Resonance Spectroscopy; Molecular Structure; Palladium; Phenols; Thiophenes; Vinyl Compounds | 2012 |
Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions.
Topics: Amides; Benzofurans; Chlorides; Esters; Indoles; Organophosphorus Compounds; Thiophenes | 2012 |
Towards β-selectivity in functional estrogen receptor antagonists.
Topics: Antineoplastic Agents; Benzofurans; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Ligands; MCF-7 Cells; Naphthalenes; Receptors, Estrogen; Structure-Activity Relationship; Thiophenes | 2012 |
Toluene dioxygenase-catalyzed cis-dihydroxylation of benzo[b]thiophenes and benzo[b]furans: synthesis of benzo[b]thiophene 2,3-oxide.
Topics: Benzofurans; Biocatalysis; Crystallography, X-Ray; Hydroxylation; Models, Molecular; Molecular Structure; Oxygenases; Stereoisomerism; Thiophenes | 2012 |
Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4.
Topics: Antimitotic Agents; Benzofurans; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colchicine; Heterocyclic Compounds; Humans; Indoles; Microscopy, Confocal; Microtubules; Stereoisomerism; Stilbenes; Thiophenes | 2012 |
An efficient tandem elimination-cyclization-desulfitative arylation of 2-(gem-dibromovinyl)phenols(thiophenols) with sodium arylsulfinates.
Topics: Arylsulfonates; Benzofurans; Cyclization; Molecular Structure; Phenols; Sodium; Thiophenes; Vinyl Compounds | 2013 |
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.
Topics: Benzofurans; Cell Line, Tumor; Cell Survival; Humans; Imidazoles; Melanoma; Naphthols; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Structure-Activity Relationship; Thiophenes | 2013 |
Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
Topics: Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Enzyme Assays; Humans; Indazoles; NAD(P)H Dehydrogenase (Quinone); Oxazoles; Oxidation-Reduction; Quinones; Thiophenes | 2013 |
Highly efficient quencher-free molecular beacon systems containing 2-ethynyldibenzofuran- and 2-ethynyldibenzothiophene-labeled 2'-deoxyuridine units.
Topics: Base Pair Mismatch; Benzofurans; Circular Dichroism; Deoxyuridine; DNA Probes; Electron Transport; Fluorescent Dyes; Oligodeoxyribonucleotides; Polymorphism, Single Nucleotide; Spectrometry, Fluorescence; Thiophenes; Transition Temperature | 2013 |
Iridium-catalyzed hydrogen transfer: synthesis of substituted benzofurans, benzothiophenes, and indoles from benzyl alcohols.
Topics: Benzofurans; Benzyl Alcohols; Catalysis; Indoles; Iridium; Molecular Structure; Stereoisomerism; Thiophenes | 2013 |
Characterization of telmisartan-derived PPARγ agonists: importance of moiety shift from position 6 to 5 on potency, efficacy and cofactor recruitment.
Topics: 3T3-L1 Cells; Animals; Benzimidazoles; Benzoates; Benzofurans; Chlorocebus aethiops; COS Cells; Diabetes Mellitus, Type 2; Humans; Ligands; Mice; PPAR gamma; Structure-Activity Relationship; Telmisartan; Thiophenes | 2012 |
Degradation of dibenzofuran via multiple dioxygenation by a newly isolated Agrobacterium sp. PH-08.
Topics: Agrobacterium; Benzofurans; Biodegradation, Environmental; Catechol 2,3-Dioxygenase; Tandem Mass Spectrometry; Thiophenes | 2014 |
A facile and general route to 3-((trifluoromethyl)thio)benzofurans and 3-((trifluoromethyl)thio)benzothiophenes.
Topics: Benzofurans; Chemistry Techniques, Synthetic; Thiophenes | 2014 |
Bioremediation of coking wastewater containing carbazole, dibenzofuran, dibenzothiophene and naphthalene by a naphthalene-cultivated Arthrobacter sp. W1.
Topics: Arthrobacter; Benzofurans; Biodegradation, Environmental; Carbazoles; Coke; Kinetics; Naphthalenes; Thiophenes; Time Factors; Toxicity Tests; Vibrio; Wastewater; Water Pollutants, Chemical | 2014 |
Asymmetric dearomatic Diels-Alder reactions of diverse heteroarenes via π-system activation.
Topics: Amines; Benzofurans; Catalysis; Cycloaddition Reaction; Furans; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Stereoisomerism; Thiophenes | 2014 |
Bioremediation of coking wastewater containing carbazole, dibenzofuran and dibenzothiophene by immobilized naphthalene-cultivated Arthrobacter sp. W1 in magnetic gellan gum.
Topics: Arthrobacter; Benzofurans; Biodegradation, Environmental; Carbazoles; Cells, Immobilized; Coke; Kinetics; Nanoparticles; Polysaccharides, Bacterial; Thiophenes; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical | 2014 |
PCP-induced deficits in murine nest building activity: employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Quinuclidines; Rotarod Performance Test; Schizophrenia; Schizophrenic Psychology; Social Behavior; Thiophenes | 2014 |
Stereoselective synthesis of C-fused pyranoindoles, pyranobenzofurans and pyranobenzothiophene scaffolds using oxa-Pictet-Spengler type reaction of vinylogous carbonates.
Topics: Benzofurans; Indoles; Molecular Structure; Pyrans; Stereoisomerism; Thiophenes | 2014 |
Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders.
Topics: Antiviral Agents; Benzimidazoles; Benzofurans; Cyclohexanols; Drug Resistance, Viral; Enzyme Inhibitors; Genotype; Hepacivirus; Humans; Purines; Pyridazines; Pyrones; Recombinant Proteins; Replicon; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Sulfonamides; Thiophenes; Triazoles; Viral Proteins | 2014 |
Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Antioxidants; Benzofurans; Binding Sites; Caenorhabditis elegans; Chalcone; Chalcones; Crystallography, X-Ray; Disease Models, Animal; Humans; Microscopy, Fluorescence; Molecular Conformation; Molecular Docking Simulation; Oxidative Stress; Protein Structure, Tertiary; Structure-Activity Relationship; Thiophenes | 2014 |
Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-fluorobenzothiophenes and benzofurans.
Topics: Benzofurans; Dose-Response Relationship, Drug; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Thiophenes | 2015 |
Synthesis of a novel class of substituted benzothiophene or benzofuran derivatives as BMP-2 up-regulators and evaluation of the BMP-2-up-regulating effects in vitro and the effects on glucocorticoid-induced osteoporosis in rats.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Cell Line; Female; Glucocorticoids; Male; Mice; Mice, Inbred Strains; Osteoporosis; Rats; Rats, Wistar; Thiophenes; Up-Regulation | 2015 |
Eco-friendly solvents for palladium-catalyzed desulfitative C-H bond arylation of heteroarenes.
Topics: Benzofurans; Catalysis; Diethyl Pyrocarbonate; Ethers; Indoles; Palladium; Pyrroles; Solvents; Sulfones; Thiophenes | 2015 |
Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.
Topics: Antineoplastic Agents; Benzofurans; Benzothiazoles; Binding Sites; Cell Line, Tumor; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Resveratrol; Stilbenes; Thiophenes; Tubulin | 2015 |
American Psychiatric Association - 168th Annual Meeting (May 16-20, 2015 - Toronto, Canada).
Topics: Alcoholism; Benzofurans; Canada; Drug Discovery; Humans; Indoles; Mental Disorders; Piperazines; Psychiatry; Quinolones; Schizophrenia; Thiophenes; Vilazodone Hydrochloride | 2015 |
Structure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents That Selectively Detect Neurofibrillary Tangles in Alzheimer's Disease Brains.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Benzimidazoles; Benzofurans; Benzothiazoles; Benzoxazoles; Brain; Humans; Iodine Radioisotopes; Male; Mice; Neurofibrillary Tangles; Pyridines; Radionuclide Imaging; Radiopharmaceuticals; Stereoisomerism; Structure-Activity Relationship; Styrenes; tau Proteins; Temporal Lobe; Thiophenes | 2015 |
Diarylthiophenes as inhibitors of the pore-forming protein perforin.
Topics: Benzofurans; Humans; Killer Cells, Natural; Perforin; Structure-Activity Relationship; Thiophenes | 2016 |
A novel integration system of magnetically immobilized cells and a pair of graphite plate-stainless iron mesh electrodes for the bioremediation of coking wastewater.
Topics: Benzofurans; Biodegradation, Environmental; Carbazoles; Cells, Immobilized; Coke; Comamonas; Electrodes; Graphite; Iron; Magnetics; Mixed Function Oxygenases; Phenol; Thiophenes; Waste Disposal, Fluid; Wastewater | 2016 |
Variation in toxicity during the biodegradation of various heterocyclic and homocyclic aromatic hydrocarbons in single and multi-substrate systems.
Topics: Benzofurans; Biodegradation, Environmental; Chryseobacterium; Environmental Pollutants; Escherichia coli; Hydrocarbons, Aromatic; Naphthalenes; Oxidoreductases; Pseudomonas fluorescens; Quinolones; Thiophenes | 2017 |
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold.
Topics: Administration, Oral; Animals; Benzofurans; Blood Glucose; Cell Line; CHO Cells; Cricetulus; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Male; Mice, Inbred ICR; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Sulfones; Thiophenes | 2017 |
New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzofurans; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Formaldehyde; Lipoxygenase Inhibitors; Male; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Wistar; Rhodanine; Structure-Activity Relationship; Thiophenes | 2017 |
Synthesis of carbonylated heteroaromatic compounds via visible-light-driven intramolecular decarboxylative cyclization of o-alkynylated carboxylic acids.
Topics: Alkynes; Benzofurans; Carboxylic Acids; Chemistry Techniques, Synthetic; Cyclization; Indoles; Light; Models, Chemical; Oxidation-Reduction; Thiophenes | 2017 |
Cometabolic Degradation of Dibenzofuran and Dibenzothiophene by a Naphthalene-Degrading Comamonas sp. JB.
Topics: Benzofurans; Biotransformation; Catechols; Comamonas; Enzymes; Metabolic Networks and Pathways; Naphthalenes; Thiophenes | 2017 |
Dibenzofuran, dibenzothiophene and N-methyl carbazole tethered 2-aminothiazoles and their cinnamamides as potent inhibitors of Mycobacterium tuberculosis.
Topics: Anti-Bacterial Agents; Benzofurans; Carbazoles; Cell Survival; Cinnamates; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazoles; Thiophenes | 2018 |
Unraveling the molecular mechanism of benzothiophene and benzofuran scaffold-merged compounds binding to anti-apoptotic Myeloid cell leukemia 1.
Topics: Apoptosis; Benzofurans; Least-Squares Analysis; Molecular Docking Simulation; Molecular Dynamics Simulation; Myeloid Cell Leukemia Sequence 1 Protein; Quantitative Structure-Activity Relationship; Reproducibility of Results; Thiophenes | 2019 |
Sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as potent carbonic anhydrase II/IX/XII inhibitors.
Topics: Benzofurans; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Isoenzymes; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Sulfonic Acids; Thiophenes | 2019 |
The Gas-Phase Formation Mechanism of Dibenzofuran (DBF), Dibenzothiophene (DBT), and Carbazole (CA) from Benzofuran (BF), Benzothiophene (BT), and Indole (IN) with Cyclopentadienyl Radical.
Topics: Benzofurans; Carbazoles; Cyclopentanes; Free Radicals; Gases; Indoles; Kinetics; Models, Chemical; Models, Molecular; Molecular Structure; Polycyclic Aromatic Hydrocarbons; Thiophenes | 2019 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish | 2020 |
Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes.
Topics: Anti-Inflammatory Agents; Benzofurans; HEK293 Cells; Humans; Lignans; NF-kappa B; Structure-Activity Relationship; Thiophenes | 2020 |
Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.
Topics: Antineoplastic Agents; Benzofurans; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Phosphoric Diester Hydrolases; Pyrophosphatases; Structure-Activity Relationship; Sulfonic Acids; Thiophenes; Tumor Cells, Cultured | 2020 |
Microenvironment-Sensitive Fluorescent Nucleotide Probes from Benzofuran, Benzothiophene, and Selenophene as Substrates for DNA Polymerases.
Topics: Benzofurans; Deoxyuridine; DNA; DNA-Directed DNA Polymerase; Nucleotides; Oligonucleotides; Thiophenes | 2022 |