thiophenes has been researched along with begacestat in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abou-Gharbia, M; Antane, M; Aschmies, S; Atchison, K; Chlenov, M; Cole, DC; Comery, T; Diamantidis, G; Ellingboe, J; Fan, K; Galante, R; Gonzales, C; Harrison, B; Ho, DM; Hoke, ME; Hu, Y; Huryn, D; Jacobsen, JS; Jain, U; Jin, M; Kreft, AF; Kremer, K; Kubrak, D; Lin, M; Lu, P; Magolda, R; Martone, R; Mayer, SC; Moore, W; Oganesian, A; Pangalos, MN; Porte, A; Reinhart, P; Resnick, L; Riddell, DR; Sonnenberg-Reines, J; Stock, JR; Sun, SC; Wagner, E; Wang, T; Woller, K; Xu, Z; Zaleska, MM; Zeldis, J; Zhang, M; Zhou, H | 1 |
| Abou-Gharbia, M; Adkins, K; Aschmies, S; Atchison, K; Balliet, C; Bard, J; Burczynski, ME; Clarke, DW; Comery, T; Forlow, SB; Frick, G; Gong, X; Gonzales, C; Harrison, B; Huang, X; Huryn, D; Jacobsen, JS; Jin, M; Kreft, A; Leach, MW; Lu, P; Magolda, R; Martone, RL; Mayer, SC; Oganesian, A; Pangalos, MN; Raje, S; Reinhart, PH; Riddell, DR; Sonnenberg-Reines, J; Sun, SC; Wagner, E; Wan, HI; Xu, JZ; Zaleska, MM; Zhou, H | 1 |
| Tomita, T | 1 |
| Hopkins, CR | 1 |
| Dumin, JA; Loureiro, RM; McKee, TD; Tate, B; Zarayskiy, V | 1 |
1 review(s) available for thiophenes and begacestat
| Article | Year |
|---|---|
[Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity].
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Humans; Sulfonamides; Tetrahydronaphthalenes; Thiophenes; Valine | 2009 |
4 other study(ies) available for thiophenes and begacestat
| Article | Year |
|---|---|
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Mice; Mice, Transgenic; Models, Molecular; Molecular Conformation; Receptor, Notch1; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Thiophenes | 2008 |
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Topics: Adolescent; Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Cricetulus; Dogs; Enzyme Inhibitors; Fear; Female; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Rats; Rats, Sprague-Dawley; Receptors, Notch; Signal Transduction; Sulfonamides; Thiophenes; Young Adult | 2009 |
ACS chemical neuroscience molecule spotlight on Begacestat (GSI-953).
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Sulfonamides; Thiophenes | 2012 |
An improved cell-based method for determining the γ-secretase enzyme activity against both Notch and APP substrates.
Topics: Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Azepines; Cell Line; Enzyme Inhibitors; Humans; Oxadiazoles; Receptors, Notch; Solid Phase Extraction; Substrate Specificity; Sulfonamides; Thiophenes | 2013 |