Compounds > thiophenes
Page last updated: 2024-08-18

thiophenes and 7-hydroxystaurosporine

thiophenes has been researched along with 7-hydroxystaurosporine in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, XM; Chen, YD; Li, HF; Liu, HC; Lu, S; Lu, T; Ran, T; Yuan, HL1
Dent, P; Eulitt, P; Mitchell, C; Park, M; Yacoub, A; Yang, C1
Choy, ML; Lee, JH; Marks, PA; Ngo, L; Venta-Perez, G1
Brown, EJ; Schoppy, DW1
Aft, RL; Cai, S; Ellis, MJ; Goiffon, RJ; Guo, Z; Hoog, J; Li, S; Lin, L; Ma, CX; Piwnica-Worms, H; Prat, A; Ryan, CE; Schaiff, WT1

Other Studies

5 other study(ies) available for thiophenes and 7-hydroxystaurosporine

ArticleYear
Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors.
    Journal of molecular modeling, 2010, Volume: 16, Issue:7

    Topics: Benzodiazepinones; Binding Sites; Biocatalysis; Checkpoint Kinase 1; Drug Design; Ligands; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Protein Structure, Tertiary; Pyrazoles; Staurosporine; Structure-Activity Relationship; Thiophenes; Urea

2010
Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
    Molecular pharmacology, 2010, Volume: 78, Issue:5

    Topics: Cell Death; Cell Line, Tumor; Checkpoint Kinase 1; Drug Synergism; Enzyme Activation; Histones; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Thiophenes; Urea

2010
Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Dec-06, Volume: 108, Issue:49

    Topics: Animals; Cell Line, Tumor; Cell Survival; Cells, Cultured; Checkpoint Kinase 1; DNA Damage; Drug Resistance; Fibroblasts; Foreskin; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Male; Mice; Protein Kinases; Quinolines; Quinuclidines; RNA Interference; Spleen; Staurosporine; Thiophenes; Urea; Vorinostat

2011
Chk'ing p53-deficient breast cancers.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:4

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Checkpoint Kinase 1; Female; Humans; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Thiophenes; Tumor Suppressor Protein p53; Urea

2012
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:4

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Camptothecin; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 1; DNA Damage; DNA, Neoplasm; Female; Genes, cdc; Genes, erbB-2; Genes, p53; Humans; Irinotecan; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Protein Kinases; Receptors, Estrogen; Receptors, Progesterone; Staurosporine; Thiophenes; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays

2012